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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PEG10 Gene

protein-coding   GIFtS: 53
GCID: GC07P094285

paternally expressed 10
 Explore 11 diseases affiliated with
PEG10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PEG10    

Aliases
for PEG10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Paternally Expressed 101 2     Retrotransposon-Derived Gag-Like Polyprotein2 3
RGAG31 2 3     Ty3/Gypsy-Like Protein2 3
KIAA10511 3 5     EDR2 3
HB-11 2     MEF3-Like Protein 12 3
MEF3L1 2     Embryonal Carcinoma Differentiation Regulated2
Mar21 2     MEF3 Like 12
Mart21 2     Retrotransposon Gag Domain Containing 32
Embryonal Carcinoma Differentiation-Regulated Protein2 3     Retrotransposon-Derived Protein PEG102
Mammalian Retrotransposon-Derived Protein 22 3     MAR23
Myelin Expression Factor 3-Like Protein 12 3     MART23
Paternally Expressed Gene 10 Protein2 3     MEF3L13
Retrotransposon Gag Domain-Containing Protein 32 3     

External Ids:    HGNC: 140051   Entrez Gene: 230892   Ensembl: ENSG000002422657   OMIM: 6098105   UniProtKB: Q86TG73   

Export aliases for PEG10 gene to outside databases

Previous GC identifers: GC07P092821 GC07P093883 GC07P093897 GC07P093930 GC07P094123 GC07P088892


Summaries
for PEG10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PEG10:
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames
(ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide
frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of
gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational
frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site
consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced
transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene.
Increased expression of this gene is associated with hepatocellular carcinomas. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of
apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by
interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as
filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By
similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP)
promoter (By similarity)

Gene Wiki entry for PEG10


Genomic Views
for PEG10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PEG10 gene promoter:
         C/EBPbeta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PEG10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEG10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21

PEG10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEG10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P094285:  view genomic region     (about GC identifiers)

Start:
 94,285,637 bp from pter      End:
 94,299,007 bp from pter
Size:
 13,371 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 93,614,786-93,628,044     

Proteins
for PEG10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7 (See protein sequence)
Recommended Name: Retrotransposon-derived protein PEG10  
Size: 708 amino acids; 80173 Da
Subunit: Interacts with ALK1, SIAH1 and SIAH2
Subcellular location: Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate
carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2
cell line. Colocalized with ALK1
Developmental stage: Expressed in placenta during the first trimester of gestation (at protein level). In placenta,
down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation
Miscellaneous: The PEG10 locus is imprinted, giving rise to paternally expressed proteins
Sequence caution: Sequence=BAA83003.2; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q96A68 Q9UPV1
Ribosomal frameshifting: 2 isoforms:  Q86TG7-1   Q86TG7-2   (Produced by conventional translation. Contains a phosphoserine at position 316. Contains a phosphoserine at position 321)

Explore the universe of human proteins at neXtProt for PEG10: NX_Q86TG7

Post-translational modifications:

  • Isoform RF1/RF2 undergoes proteolytic cleavage1
  • View neXtProt modification sites for NX_Q86TG7

    • PEG10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035242.1  NP_001165908.1  NP_001165909.1  NP_001171890.1  NP_001171891.1  NP_055883.2  

    ENSEMBL proteins: 
     ENSP00000417587   ENSP00000418944  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PEG10
    OriGene Protein Over-expression Lysate: PEG10
    OriGene Custom Protein Services for PEG10 
    GenScript Custom Purified and Recombinant Proteins Services for PEG10
    Novus Biologicals PEG10 Protein
    Novus Biologicals PEG10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PEG10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--


    PEG10 for ontologies           About GeneDecksing



    PEG10 Antibody Products: 
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    Search for Antibodies for PEG10 at Abcam  
    Uscn Antibodies for PEG10
    ThermoFisher Antibody for PEG10

    Assay Products for PEG10: 
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    Uscn ELISAs and CLIAs for PEG10

    Protein Domains /
    Families
    for PEG10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PEG10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR021109 Peptidase_aspartic
     IPR013242 RVP_2
     IPR005162 Retrotrans_gag
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q86TG7

    ProtoNet protein and cluster: Q86TG7

    1 Blocks protein family: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
    Similarity: Contains 1 CCHC-type zinc finger


    Function
    for PEG10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
    Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of
    apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by
    interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as
    filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By
    similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP)
    promoter (By similarity)
    Induction: Up-regulated by MYC and dihydrotestosterone (DHT)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PEG10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEG10
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG10 (see all 113):
    hsa-miR-411* hsa-miR-549 hsa-miR-607 hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-502-3p hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEG10 (see all 4)
    OriGene shRNA RFP: PEG10
    OriGene siRNA: PEG10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PEG10

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEG10 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEG10 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): PEG10 (NM_015068)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG10 

    Cell Line
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    Search LifeMap BioReagents cell lines for PEG10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG10

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    PEG10 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Peg10tm1Fuis for PEG10
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Peg10):
     cellular  embryogenesis  growth/size  mortality/aging 

    PEG10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PEG10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Validated targets of C-MYC transcriptional activation
    		Validated targets of C-MYC transcriptional activation1.00


    1 BioSystems Pathway for PEG10 
        Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PEG10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for PEG10 (Q86TG71, 2, 3 ENSP000004175874) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60796 I2D: score=2 
    TOLLIPQ9H0E21, 3, ENSP000003147334EBI-2858265,EBI-74615 I2D: score=1 STRING: ENSP00000314733
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=3 STRING: ENSP00000349156
    SIAH2O432553, ENSP000003224574I2D: score=3 STRING: ENSP00000322457
    IRF4Q153063, ENSP000003703434I2D: score=1 STRING: ENSP00000370343
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001890placenta development IEA--
    GO:0006915apoptotic process IEA--
    GO:0030154cell differentiation IEA--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IDA15611116


    PEG10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PEG10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PEG10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PEG10
    1 Novoseek chemical compound relationship for PEG10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peg-10 97.1 33 16423995 (10), 12810624 (5), 16225771 (3), 17082584 (3)

    Search CenterWatch for drugs/clinical trials and news about PEG10 

    Transcripts
    for PEG10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PEG10 gene (6 alternative transcripts): 
    NM_001040152.1  NM_001172437.1  NM_001172438.1  NM_001184961.1  NM_001184962.1  NM_015068.3  

    Unigene Cluster for PEG10:

    Paternally expressed 10
    Hs.147492  [show with all ESTs]
    Unigene Representative Sequence: NM_001040152
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482108(uc003uno.3 uc011kie.2) ENST00000488574 ENST00000493935
    ENST00000465184

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PEG10
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEG10
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG10 (see all 113):
    hsa-miR-411* hsa-miR-549 hsa-miR-607 hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-502-3p hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEG10 (see all 4)
    OriGene shRNA RFP: PEG10
    OriGene siRNA: PEG10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEG10 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEG10 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): PEG10 (NM_015068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG10 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEG10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PEG10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEG10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG10

    Additional cDNA sequence: 

    AB028974.1 AB049150.1 AB049834.1 AF038197.1 AF216076.1 AK025529.1 AK299837.1 BC015448.1 
    BC050659.2 

    15 DOTS entries:

    DT.85104958  DT.100827436  DT.121111180  DT.100827438  DT.95100690  DT.92068581  DT.40132503  DT.121111144 
    DT.100827437  DT.100827439  DT.100827440  DT.121111139  DT.95258629  DT.92467642  DT.95100691 

    24/464 AceView cDNA sequences (see all 464):

    AI150826 AW517937 F10908 AA330266 AL039882 AA719936 T34901 W67326 
    AI141868 BG251105 AA223225 R24585 AB028974 AW291233 F11842 AU119937 
    AW298081 BF110801 BU581318 BE671887 AA702806 F02251 AA911307 BF056460 

    GeneLoc Exon Structure


    Expression
    for PEG10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PEG10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGTTATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PEG10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Definitive Endoderm (Generation of beta c...)

    See PEG10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PEG10

    SOURCE GeneReport for Unigene cluster: Hs.147492

    UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
    Tissue specificity: Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the
    placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells.
    Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary,
    testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular
    carcinomas (HCC)

        SABiosciences Custom PCR Arrays for PEG10
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG10

    Orthologs
    for PEG10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PEG10 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Peg101 , 5 paternally expressed 101, 5 73.96(n)1
    69.62(a)1    		   6 (1.81 cM)5
    1706761  NM_130877.21  NP_570947.21 
     47473065 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 21)    		 --
    		 37(a)
    37(a)
    (see all 21)    		 many → 1
    many → 1
    (see all 21)    		 AAWZ02038509(10393-11069)
    GL343308.1(1367711-1368455)


    ENSEMBL Gene Tree for PEG10 (if available)
    TreeFam Gene Tree for PEG10 (if available) 

    Paralogs
    for PEG10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PEG10 gene
    ZCCHC52  ZCCHC162  
    2 SIMAP similar genes for PEG10 using alignment to 1 protein entry:     PEG10_HUMAN:
    FAM127C    FAM127B

    PEG10 for paralogs           About GeneDecksing



    Genomic Variants
    for PEG10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/161 NCBI SNPs in PEG10 are shown (see all 161)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs102396431,2
    		C,H--88897924(+) TATGTT/CGTGAT 6 -- int14Minor allele frequency- C:0.00NS EA 418
    rs794668031,2
    		C,F,--88898235(+) TGACAT/CTGGGG 6 -- int11Minor allele frequency- C:0.03NA 120
    rs45309671,2
    		H--88898246(+) CATGGG/AAGGTA 6 -- int14Minor allele frequency- A:0.00NS EA 414
    rs1887185171,2
    		C,--88899342(+) AAATTA/GTGGTC 6 -- int10--------
    rs744057221,2
    		--88899941(+) AATGTA/GTAAGT 6 -- int11Minor allele frequency- G:0.01NA 120
    rs1126882891,2
    		--88899990(+) AGCGGG/ATTTTG 8 /I /V ut51 mis11Minor allele frequency- A:0.50CSA 2
    rs32090611,2
    		C--88900859(+) CTCTCC/ACACCT 12 /S syn11Minor allele frequency- A:0.00MN 184
    rs1125356631,2
    		C--88902171(+) CCCAGA/G/TGGGAC 15 E G V ut31 mis11CSA 1
    rs1995936581,2
    		C--88902261(+) ACAGTA/CCCCGC 9 Y S ut31 mis10--------
    rs789667381,2
    		C,F,--88902419(+) GCTACT/CGTATC 6 -- ut311Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for PEG10 (94285637 - 94299007 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PEG10
         1 CNV: 5243

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    Disorders / Diseases
    for PEG10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PEG10 for disorders           About GeneDecksing

    OMIM gene information: 609810    OMIM disorders: --

    11 diseases for PEG10:    About MalaCards
    hepatocellular carcinoma    carcinoma    embryonal carcinoma    chronic lymphocytic leukemia
    lymphocytic leukemia    leukemia    breast carcinoma    prostatitis
    thyroiditis    pancreatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for PEG10:
    Multiple personality disorder

    3 Novoseek disease relationships for PEG10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b-all 81.7 5 16225771 (2), 17082584 (2)
    leukemia lymphocytic chronic 60.6 1 16225771 (1)
    hepatocellular carcinoma 38.2 5 12810624 (2), 16423995 (2)

    Human Genome Epidemiology (HuGE) Navigator: PEG10 (1 document)

    Export disorders for PEG10 gene to outside databases

    Publications
    for PEG10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PEG10 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with PEG10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21. (PubMed id 11318613)1, 2, 3 Ono R.... Ishino F. (2001)
    2. PEG10 is a c-MYC target gene in cancer cells. (PubMed id 16423995)1, 2, 9 Li C.M....Tycko B. (2006)
    3. Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. (PubMed id 12810624)1, 2, 9 Okabe H.... Nakamura Y. (2003)
    4. Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia. (PubMed id 17621626)1, 2 Kainz B.... Jaeger U. (2007)
    5. Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. (PubMed id 17942406)1, 2 Clark M.B.... Tate W.P. (2007)
    6. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PubMed id 15716091)1, 3 Brandt J.... Volff J.-N. (2005)
    7. Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. (PubMed id 15611116)1, 2 Lux A.... Hafner M. (2005)
    8. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PubMed id 16093683)1, 3 Brandt J....Volff J.N. (2005)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta. (PubMed id 12620933)1, 2 Smallwood A.... Banerjee S. (2003)

    External Searches for PEG10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PEG10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23089 HGNC: 14005 AceView: PEG10 Ensembl:ENSG00000242265 euGenes: HUgn23089
    ECgene: PEG10 H-InvDB: PEG10

    Other Databases showing PEG10 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1051

    Specialized Databases showing PEG10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PEG10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PEG10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PEG10 gene:
    Search GeneIP for patents involving PEG10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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