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Aliases for PEG10 Gene

Aliases for PEG10 Gene

  • Paternally Expressed 10 2 3
  • Retrotransposon Gag Domain-Containing Protein 3 3 4
  • Retrotransposon-Derived Gag-Like Polyprotein 3 4
  • Mammalian Retrotransposon-Derived Protein 2 3 4
  • Myelin Expression Factor 3-Like Protein 1 3 4
  • Paternally Expressed Gene 10 Protein 3 4
  • Ty3/Gypsy-Like Protein 3 4
  • KIAA1051 4 6
  • MART2 3 4
  • RGAG3 3 4
  • Mar2 3 4
  • EDR 3 4
  • Embryonal Carcinoma Differentiation-Regulated Protein 4
  • Embryonal Carcinoma Differentiation Regulated 3
  • Retrotransposon-Derived Protein PEG10 3
  • MEF3-Like Protein 1 4
  • MEF3 Like 1 3
  • MEF3L1 4
  • MEF3L 3
  • Hb-1 3

External Ids for PEG10 Gene

Summaries for PEG10 Gene

Entrez Gene Summary for PEG10 Gene

  • This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for PEG10 Gene

PEG10 (Paternally Expressed 10) is a Protein Coding gene. Diseases associated with PEG10 include multiple personality disorder and hepatocellular carcinoma. Among its related pathways are Validated targets of C-MYC transcriptional activation. An important paralog of this gene is ZCCHC16.

UniProtKB/Swiss-Prot for PEG10 Gene

  • Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5-GCCTGTCTTT-3 DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).

Gene Wiki entry for PEG10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEG10 Gene

Genomics for PEG10 Gene

Genomic Location for PEG10 Gene

Start:
94,656,325 bp from pter
End:
94,669,695 bp from pter
Size:
13,371 bases
Orientation:
Plus strand

Genomic View for PEG10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PEG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEG10 Gene

Regulatory Elements for PEG10 Gene

Transcription factor binding sites by QIAGEN in the PEG10 gene promoter:

Proteins for PEG10 Gene

  • Protein details for PEG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TG7-PEG10_HUMAN
    Recommended name:
    Retrotransposon-derived protein PEG10
    Protein Accession:
    Q86TG7
    Secondary Accessions:
    • Q96A68
    • Q9UPV1

    Protein attributes for PEG10 Gene

    Size:
    708 amino acids
    Molecular mass:
    80173 Da
    Quaternary structure:
    • Interacts with ALK1, SIAH1 and SIAH2.
    Miscellaneous:
    • The PEG10 locus is imprinted, giving rise to paternally expressed proteins
    SequenceCaution:
    • Sequence=BAA83003.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for PEG10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEG10 Gene

Proteomics data for PEG10 Gene at MOPED

Post-translational modifications for PEG10 Gene

No data available for DME Specific Peptides for PEG10 Gene

Domains for PEG10 Gene

Protein Domains for PEG10 Gene

UniProtKB/Swiss-Prot:

PEG10_HUMAN
Similarity:
  • Contains 1 CCHC-type zinc finger.:
    • Q86TG7
genes like me logo Genes that share domains with PEG10: view

No data available for Gene Families for PEG10 Gene

Function for PEG10 Gene

Molecular function for PEG10 Gene

UniProtKB/Swiss-Prot Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5-GCCTGTCTTT-3 DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by MYC and dihydrotestosterone (DHT).

Gene Ontology (GO) - Molecular Function for PEG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15611116
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PEG10: view
genes like me logo Genes that share phenotypes with PEG10: view

Animal Models for PEG10 Gene

MGI Knock Outs for PEG10:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PEG10 Gene

Localization for PEG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEG10 Gene

Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEG10 Gene COMPARTMENTS Subcellular localization image for PEG10 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PEG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PEG10: view

Pathways for PEG10 Gene

genes like me logo Genes that share pathways with PEG10: view

Pathways by source for PEG10 Gene

1 BioSystems pathway for PEG10 Gene

Gene Ontology (GO) - Biological Process for PEG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development --
GO:0006915 apoptotic process IEA --
GO:0030154 cell differentiation IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 15611116
genes like me logo Genes that share ontologies with PEG10: view

Compounds for PEG10 Gene

(1) Novoseek inferred chemical compound relationships for PEG10 Gene

Compound -log(P) Hits PubMed IDs
peg-10 97.1 21
genes like me logo Genes that share compounds with PEG10: view

Transcripts for PEG10 Gene

Unigene Clusters for PEG10 Gene

Paternally expressed 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEG10 Gene

No ASD Table

Relevant External Links for PEG10 Gene

GeneLoc Exon Structure for
PEG10
ECgene alternative splicing isoforms for
PEG10

Expression for PEG10 Gene

mRNA expression in normal human tissues for PEG10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEG10 Gene

This gene is overexpressed in Adrenal Gland (7.4), Brain - Hypothalamus (7.2), Brain - Nucleus accumbens (basal ganglia) (6.3), and Pituitary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEG10 Gene

SOURCE GeneReport for Unigene cluster for PEG10 Gene Hs.147492

mRNA Expression by UniProt/SwissProt for PEG10 Gene

Q86TG7-PEG10_HUMAN
Tissue specificity: Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).
genes like me logo Genes that share expressions with PEG10: view

Orthologs for PEG10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PEG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEG10 36
  • 99.91 (n)
  • 100 (a)
PEG10 37
  • 46 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEG10 36
  • 84.62 (n)
  • 89.66 (a)
dog
(Canis familiaris)
Mammalia PEG10 36
  • 87.39 (n)
  • 94.28 (a)
PEG10 37
  • 40 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Peg10 36
  • 76.16 (n)
  • 73.2 (a)
Peg10 16
Peg10 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553587 36
  • 72.95 (n)
  • 67.48 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 34 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 33 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
Species with no ortholog for PEG10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PEG10 Gene

ENSEMBL:
Gene Tree for PEG10 (if available)
TreeFam:
Gene Tree for PEG10 (if available)

Paralogs for PEG10 Gene

Paralogs for PEG10 Gene

Selected SIMAP similar genes for PEG10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PEG10: view

Variants for PEG10 Gene

Sequence variations from dbSNP and Humsavar for PEG10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13073 -- 94,667,457(+) TCATC(C/T)GCTCT utr-variant-3-prime
rs14444 -- 94,668,508(-) AATTC(A/T)TCTAT utr-variant-3-prime
rs1059044 -- 94,669,125(+) TCTTT(G/T)TGTAA utr-variant-3-prime
rs1059224 -- 94,668,387(+) CTTTA(A/G)ATTTT utr-variant-3-prime
rs1136429 -- 94,667,498(+) TTAGT(A/G)TAATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PEG10 Gene

Variant ID Type Subtype PubMed ID
esv2422248 CNV Duplication 17116639
esv2734834 CNV Deletion 23290073
esv2734835 CNV Deletion 23290073
esv2734836 CNV Deletion 23290073
esv2734837 CNV Deletion 23290073
esv1011269 CNV Deletion 20482838
esv2734838 CNV Deletion 23290073
esv2734840 CNV Deletion 23290073

Relevant External Links for PEG10 Gene

HapMap Linkage Disequilibrium report
PEG10

Disorders for PEG10 Gene

(1) University of Copenhagen DISEASES for PEG10 Gene

(3) Novoseek inferred disease relationships for PEG10 Gene

Disease -log(P) Hits PubMed IDs
b-all 81.7 4
leukemia lymphocytic chronic 60.6 1
hepatocellular carcinoma 38.2 4

Relevant External Links for PEG10

Genetic Association Database (GAD)
PEG10
Human Genome Epidemiology (HuGE) Navigator
PEG10
genes like me logo Genes that share disorders with PEG10: view

No data available for UniProtKB/Swiss-Prot for PEG10 Gene

Publications for PEG10 Gene

  1. PEG10 is a c-MYC target gene in cancer cells. (PMID: 16423995) Li C.-M. … Tycko B. (Cancer Res. 2006) 3 4 23
  2. A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21. (PMID: 11318613) Ono R. … Ishino F. (Genomics 2001) 2 3 4
  3. Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. (PMID: 12810624) Okabe H. … Nakamura Y. (Cancer Res. 2003) 3 4 23
  4. PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia. (PMID: 16225771) Hu C. … Tan J. (Cell. Mol. Immunol. 2004) 3 23
  5. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3

Products for PEG10 Gene

Sources for PEG10 Gene

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