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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PEG10 Gene

protein-coding   GIFtS: 55
GCID: GC07P094285

Paternally Expressed 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Paternally Expressed 101 2     HB-12
Embryonal Carcinoma Differentiation-Regulated Protein2 3     MEF3L2
Mammalian Retrotransposon-Derived Protein 22 3     Mar22
Myelin Expression Factor 3-Like Protein 12 3     Mart22
Paternally Expressed Gene 10 Protein2 3     Embryonal Carcinoma Differentiation Regulated2
Retrotransposon Gag Domain-Containing Protein 32 3     MEF3 Like 12
Retrotransposon-Derived Gag-Like Polyprotein2 3     Retrotransposon Gag Domain Containing 32
Ty3/Gypsy-Like Protein2 3     Retrotransposon-Derived Protein PEG102
EDR2 3     MAR23
RGAG32 3     MART23
MEF3-Like Protein 12 3     MEF3L13
KIAA10513 5     

External Ids:    HGNC: 140051   Entrez Gene: 230892   Ensembl: ENSG000002422657   OMIM: 6098105   UniProtKB: Q86TG73   

Export aliases for PEG10 gene to outside databases

Previous GC identifers: GC07P092821 GC07P093883 GC07P093897 GC07P093930 GC07P094123 GC07P088892


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PEG10 Gene:
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading
frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a
-1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a
sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the
result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2.
It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms
resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start
codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular
carcinomas. (provided by RefSeq, May 2010)

GeneCards Summary for PEG10 Gene: 
PEG10 (paternally expressed 10) is a protein-coding gene. Diseases associated with PEG10 include multiple personality disorder, and b-cell chronic lymphocytic leukemia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZCCHC5.

UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of
apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling
by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension,
such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation
(By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein
(MBP) promoter (By similarity)

Gene Wiki entry for PEG10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PEG10 gene promoter:
         C/EBPbeta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PEG10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEG10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21

PEG10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEG10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P094285:  view genomic region     (about GC identifiers)

Start:
94,285,637 bp from pter      End:
94,299,007 bp from pter
Size:
13,371 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 93,614,786-93,628,044     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7 (See protein sequence)
Recommended Name: Retrotransposon-derived protein PEG10  
Size: 708 amino acids; 80173 Da
Subunit: Interacts with ALK1, SIAH1 and SIAH2
Subcellular location: Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate
carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the
Hep-G2 cell line. Colocalized with ALK1
Developmental stage: Expressed in placenta during the first trimester of gestation (at protein level). In
placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation
Miscellaneous: The PEG10 locus is imprinted, giving rise to paternally expressed proteins
Sequence caution: Sequence=BAA83003.2; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q96A68 Q9UPV1
Ribosomal frameshifting: 2 isoforms:  Q86TG7-1   Q86TG7-2   (Produced by conventional translation. Contains a phosphoserine at position 316. Contains a phosphoserine at position 321)

Explore the universe of human proteins at neXtProt for PEG10: NX_Q86TG7

Explore proteomics data for PEG10 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform RF1/RF2 undergoes proteolytic cleavage
  • View neXtProt modification sites for NX_Q86TG7

  • PEG10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PEG10 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001035242.1  NP_001165908.1  NP_001165909.1  NP_001171890.1  NP_001171891.1  NP_055883.2  

    ENSEMBL proteins: 
     ENSP00000417587   ENSP00000418944  

    Human Recombinant Protein Products for PEG10: 
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    OriGene MassSpec for PEG10 
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    Novus Biologicals PEG10 Protein
    Novus Biologicals PEG10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PEG10 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    PEG10 for ontologies           About GeneDecksing



    PEG10 Antibody Products: 
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    Abcam antibodies for PEG10
    Cloud-Clone Corp. Antibodies for PEG10 
    ThermoFisher Antibody for PEG10
    LSBio Antibodies in human, mouse, rat for PEG10 

    Assay Products for PEG10: 
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    Cloud-Clone Corp. ELISAs for PEG10 
    Cloud-Clone Corp. CLIAs for PEG10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR021109 Peptidase_aspartic
     IPR013242 RVP_2
     IPR005162 Retrotrans_gag
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q86TG7

    ProtoNet protein and cluster: Q86TG7

    1 Blocks protein domain: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
    Similarity: Contains 1 CCHC-type zinc finger


    PEG10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEG10_HUMAN, Q86TG7
    Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of
    apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling
    by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension,
    such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation
    (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein
    (MBP) promoter (By similarity)
    Induction: Up-regulated by MYC and dihydrotestosterone (DHT)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15611116
    GO:0008270zinc ion binding IEA--
         
    PEG10 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Peg10):
     cellular  embryogenesis  growth/size  mortality/aging 

    PEG10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Peg10tm1Fuis for PEG10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PEG10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PEG10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PEG10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PEG10 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEG10
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG10 (see all 113):
    hsa-miR-411* hsa-miR-549 hsa-miR-607 hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-502-3p hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): PEG10 (NM_015068)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG10
    Sirion Biotech Customized lentivirus for stable overexpression of PEG10 
                         Customized lentivirus expression plasmids for stable overexpression of PEG10 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PEG10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    1 BioSystems Pathway for PEG10
        Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PEG10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for PEG10 (Q86TG71, 2, 3 ENSP000004175874) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60796 I2D: score=2 
    TOLLIPQ9H0E21, 3, ENSP000003147334EBI-2858265,EBI-74615 I2D: score=1 STRING: ENSP00000314733
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=3 STRING: ENSP00000349156
    SIAH2O432553, ENSP000003224574I2D: score=3 STRING: ENSP00000322457
    IRF4Q153063, ENSP000003703434I2D: score=1 STRING: ENSP00000370343
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001890placenta development IEA--
    GO:0006915apoptotic process IEA--
    GO:0030154cell differentiation IEA--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IDA15611116

    PEG10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PEG10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PEG10

    1 Novoseek inferred chemical compound relationship for PEG10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peg-10 97.1 33 16423995 (10), 12810624 (5), 16225771 (3), 17082584 (3)

    Search CenterWatch for drugs/clinical trials and news about PEG10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PEG10 gene (6 alternative transcripts): 
    NM_001040152.1  NM_001172437.1  NM_001172438.1  NM_001184961.1  NM_001184962.1  NM_015068.3  

    Unigene Cluster for PEG10:

    Paternally expressed 10
    Hs.147492  [show with all ESTs]
    Unigene Representative Sequence: NM_001040152
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482108(uc003uno.3 uc011kie.2) ENST00000488574 ENST00000493935
    ENST00000465184
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEG10
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG10 (see all 113):
    hsa-miR-411* hsa-miR-549 hsa-miR-607 hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-502-3p hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PEG10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG10
    Clone
    Products:
         
    OriGene clones in human, mouse for PEG10 (see all 23)
    OriGene ORF clones in mouse, rat for PEG10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): PEG10 (NM_015068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG10
    Sirion Biotech Customized lentivirus for stable overexpression of PEG10 
                         Customized lentivirus expression plasmids for stable overexpression of PEG10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PEG10
    OriGene qSTAR qPCR primer pairs in human, mouse for PEG10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PEG10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEG10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG10

    Additional mRNA sequence: 

    AB028974.1 AB049150.1 AB049834.1 AF038197.1 AF216076.1 AK025529.1 AK299837.1 BC015448.1 
    BC050659.2 

    15 DOTS entries:

    DT.85104958  DT.100827436  DT.121111180  DT.100827438  DT.95100690  DT.92068581  DT.40132503  DT.121111144 
    DT.100827437  DT.100827439  DT.100827440  DT.121111139  DT.95258629  DT.92467642  DT.95100691 

    24/464 AceView cDNA sequences (see all 464):

    AA827266 BQ015947 BU077902 CR601832 BE218988 T31573 F12914 W81411 
    CA841771 F10518 F10908 F13518 AI681877 F02251 AF216076 AI341529 
    AA128418 CR620082 H88090 AI299566 AA902260 BF795909 BQ614057 AA702806 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PEG10 expression in normal human tissues (normalized intensities)      PEG10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTATAA
    PEG10 Expression
    About this image


    PEG10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 5 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Adrenal Gland (Endocrine System)
             Adrenal Cortex   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium

    See PEG10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PEG10

    SOURCE GeneReport for Unigene cluster: Hs.147492

    UniProtKB/Swiss-Prot: PEG10_HUMAN, Q86TG7
    Tissue specificity: Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the
    placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells.
    Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung,
    ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and
    hepatocellular carcinomas (HCC)

        SABiosciences Custom PCR Arrays for PEG10
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PEG10 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Peg101 , 5 paternally expressed 101, 5 73.96(n)1
    69.62(a)1
      6 (1.81 cM)5
    1706761  NM_130877.21  NP_570947.21 
     47473065 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 68)
    Uncharacterized protein
    (see all 68)
    37(a)
    36(a)
    (see all 68)
    many ↔ many
    many ↔ many
    (see all 68)
    GL344745.1(14969-15643)
    GL343193.1(3591167-3592480)


    ENSEMBL Gene Tree for PEG10 (if available)
    TreeFam Gene Tree for PEG10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PEG10 gene
    ZCCHC52  ZCCHC162  
    2 SIMAP similar genes for PEG10 using alignment to 1 protein entry:     PEG10_HUMAN:
    FAM127C    FAM127B

    PEG10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/207 SNPs in PEG10 are shown (see all 207)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715525201,2
    C,F--94287589(+) CCCAGG/ACCCCA 6 -- int11Minor allele frequency- A:0.00NA 2
    rs1808860971,2
    --94287634(+) CCCAGA/GCCCCG 6 -- int10--------
    rs1389151411,2
    --94287639(+) GCCCCA/GCCTCT 6 -- int10--------
    rs1862327921,2
    --94287679(+) CCCAGA/GCCCCG 6 -- int10--------
    rs744726281,2
    C,F--94287779(+) GCCTCT/CCCAAG 6 -- int11Minor allele frequency- C:0.15EA 120
    rs1904878191,2
    --94287939(+) CTGGCA/TGTACA 6 -- int10--------
    rs125341761,2
    C,H--94288136(+) AAGGGA/CCCTTG 6 -- int14Minor allele frequency- C:0.00NS EA 418
    rs1817600131,2
    --94288147(+) TAAACA/TGACAT 6 -- int10--------
    rs1865945471,2
    --94288276(+) CACTAC/GTGGAC 6 -- int10--------
    rs1919615631,2
    --94288363(+) TTTGCA/GTGCCT 6 -- int10--------

    HapMap Linkage Disequilibrium report for PEG10 (94285637 - 94299007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PEG10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734838CNV Deletion23290073
    esv2734840CNV Deletion23290073
    esv1011269CNV Deletion20482838
    esv2734835CNV Deletion23290073
    esv2734834CNV Deletion23290073
    esv2734836CNV Deletion23290073
    esv2734837CNV Deletion23290073
    esv2422248CNV Duplication17116639

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609810    OMIM disorders: --

    10 diseases for PEG10:    About MalaCards
    multiple personality disorder    b-cell chronic lymphocytic leukemia    personality disorder    hepatocellular carcinoma
    chronic lymphocytic leukemia    leukemia    thyroiditis    pancreatitis
    hepatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PEG10:
    Multiple personality disorder

    PEG10 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for PEG10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b-all 81.7 5 16225771 (2), 17082584 (2)
    leukemia lymphocytic chronic 60.6 1 16225771 (1)
    hepatocellular carcinoma 38.2 5 12810624 (2), 16423995 (2)

    Genetic Association Database (GAD): PEG10
    Human Genome Epidemiology (HuGE) Navigator: PEG10 (1 document)

    Export disorders for PEG10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PEG10 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with PEG10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21. (PubMed id 11318613)1, 2, 3 Ono R.... Ishino F. (2001)
    2. PEG10 is a c-MYC target gene in cancer cells. (PubMed id 16423995)1, 2, 9 Li C.M....Tycko B. (2006)
    3. Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. (PubMed id 12810624)1, 2, 9 Okabe H.... Nakamura Y. (2003)
    4. Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia. (PubMed id 17621626)1, 2 Kainz B.... Jaeger U. (2007)
    5. Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. (PubMed id 17942406)1, 2 Clark M.B.... Tate W.P. (2007)
    6. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PubMed id 15716091)1, 3 Brandt J.... Volff J.-N. (2005)
    7. Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. (PubMed id 15611116)1, 2 Lux A.... Hafner M. (2005)
    8. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PubMed id 16093683)1, 3 Brandt J....Volff J.N. (2005)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta. (PubMed id 12620933)1, 2 Smallwood A.... Banerjee S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23089 HGNC: 14005 AceView: PEG10 Ensembl:ENSG00000242265 euGenes: HUgn23089
    ECgene: PEG10 H-InvDB: PEG10

    (According to HUGE)
    About This Section
    HUGE: KIAA1051

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PEG10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PEG10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PEG10 gene:
    Search GeneIP for patents involving PEG10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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