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Aliases for PECR Gene

Aliases for PECR Gene

  • Peroxisomal Trans-2-Enoyl-CoA Reductase 2 3
  • TERP 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 29C Member 1 3 4
  • 2,4-Dienoyl-CoA Reductase-Related Protein 3 4
  • EC 1.3.1.38 4 63
  • HPDHASE 3 4
  • SDR29C1 3 4
  • PVI-ARL 3 4
  • DCR-RP 3 4
  • Short Chain Dehydrogenase/Reductase Family 29C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 29C 2
  • Putative Short Chain Alcohol Dehydrogenase 3
  • HSA250303 3
  • Member 1 2
  • PVIARL 3
  • DCRRP 3

External Ids for PECR Gene

Previous GeneCards Identifiers for PECR Gene

  • GC02M215065
  • GC02M215627
  • GC02M216867
  • GC02M217105
  • GC02M216728
  • GC02M216611
  • GC02M208760

Summaries for PECR Gene

GeneCards Summary for PECR Gene

PECR (Peroxisomal Trans-2-Enoyl-CoA Reductase) is a Protein Coding gene. Among its related pathways are Peroxisome and Mitochondrial LC-Fatty Acid Beta-Oxidation. GO annotations related to this gene include receptor binding and trans-2-enoyl-CoA reductase (NADPH) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for PECR Gene

  • Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity

Gene Wiki entry for PECR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PECR Gene

Genomics for PECR Gene

Regulatory Elements for PECR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PECR Gene

Start:
215,996,329 bp from pter
End:
216,082,955 bp from pter
Size:
86,627 bases
Orientation:
Minus strand

Genomic View for PECR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PECR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PECR Gene

Proteins for PECR Gene

  • Protein details for PECR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY49-PECR_HUMAN
    Recommended name:
    Peroxisomal trans-2-enoyl-CoA reductase
    Protein Accession:
    Q9BY49
    Secondary Accessions:
    • B2RE42
    • Q53TC4
    • Q6IAK9
    • Q9NRD4
    • Q9NY60
    • Q9P1A4

    Protein attributes for PECR Gene

    Size:
    303 amino acids
    Molecular mass:
    32544 Da
    Quaternary structure:
    • Interacts with PEX5, probably required to target it into peroxisomes.
    SequenceCaution:
    • Sequence=AAF69798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PECR Gene

    Alternative splice isoforms for PECR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PECR Gene

Proteomics data for PECR Gene at MOPED

Selected DME Specific Peptides for PECR Gene

Post-translational modifications for PECR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PECR Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PECR Gene

Gene Families for PECR Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Suggested Antigen Peptide Sequences for PECR Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY49

UniProtKB/Swiss-Prot:

PECR_HUMAN :
  • Q9BY49
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with PECR: view

Function for PECR Gene

Molecular function for PECR Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity
UniProtKB/Swiss-Prot Induction: Not induced by IR.

Enzyme Numbers (IUBMB) for PECR Gene

Gene Ontology (GO) - Molecular Function for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005102 receptor binding IPI 11669066
GO:0008670 NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA 11669066
GO:0016491 oxidoreductase activity --
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity IDA 16546181
genes like me logo Genes that share ontologies with PECR: view

Phenotypes for PECR Gene

GenomeRNAi human phenotypes for PECR:
genes like me logo Genes that share phenotypes with PECR: view

Animal Model Products

CRISPR Products

miRNA for PECR Gene

miRTarBase miRNAs that target PECR

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PECR

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PECR Gene

Localization for PECR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PECR Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PECR Gene COMPARTMENTS Subcellular localization image for PECR gene
Compartment Confidence
peroxisome 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IDA 11669066
GO:0005778 peroxisomal membrane ISS 10811639
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PECR: view

Pathways for PECR Gene

genes like me logo Genes that share pathways with PECR: view

Pathways by source for PECR Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BY49-PECR_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis

Gene Ontology (GO) - Biological Process for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008152 metabolic process --
GO:0033306 phytol metabolic process IDA 16546181
GO:0055114 oxidation-reduction process IDA 16546181
genes like me logo Genes that share ontologies with PECR: view

Compounds for PECR Gene

(36) HMDB Compounds for PECR Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(1) Drugbank Compounds for PECR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenine
  • 1H-Purin-6-amine
73-24-5 target
genes like me logo Genes that share compounds with PECR: view

Transcripts for PECR Gene

Unigene Clusters for PECR Gene

Peroxisomal trans-2-enoyl-CoA reductase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PECR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PECR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for PECR Gene

GeneLoc Exon Structure for
PECR
ECgene alternative splicing isoforms for
PECR

Expression for PECR Gene

mRNA expression in normal human tissues for PECR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PECR Gene

This gene is overexpressed in Liver (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PECR Gene

SOURCE GeneReport for Unigene cluster for PECR Gene Hs.281680

genes like me logo Genes that share expressions with PECR: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PECR Gene

Orthologs for PECR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PECR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PECR 35
  • 99.78 (n)
  • 99.67 (a)
PECR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PECR 35
  • 81.84 (n)
  • 77.08 (a)
PECR 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PECR 35
  • 81.41 (n)
  • 74.59 (a)
PECR 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pecr 35
  • 77.34 (n)
  • 72.61 (a)
Pecr 16
Pecr 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PECR 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pecr 35
  • 77.12 (n)
  • 71.95 (a)
chicken
(Gallus gallus)
Aves PECR 35
  • 65.22 (n)
  • 62.82 (a)
PECR 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PECR 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pecr 35
  • 62.17 (n)
  • 62.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14009 35
zebrafish
(Danio rerio)
Actinopterygii pecr 35
  • 60.73 (n)
  • 58.56 (a)
pecr 36
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 36
  • 32 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15521g 35
  • 46.52 (n)
  • 36.17 (a)
rice
(Oryza sativa)
Liliopsida Os11g0443700 35
  • 49.58 (n)
  • 40.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2168 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for PECR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PECR Gene

ENSEMBL:
Gene Tree for PECR (if available)
TreeFam:
Gene Tree for PECR (if available)

Paralogs for PECR Gene

Selected SIMAP similar genes for PECR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PECR: view

Variants for PECR Gene

Sequence variations from dbSNP and Humsavar for PECR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11953 -- 216,078,182(-) gatta(C/T)aggcg intron-variant
rs705648 -- 216,069,069(+) tgctc(C/T)aatat intron-variant
rs828904 -- 216,069,808(+) gtggg(C/T)gcctg intron-variant
rs828905 -- 216,070,953(+) tccag(C/T)ggtat intron-variant
rs828906 -- 216,073,989(+) AGAAA(C/T)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PECR Gene

Variant ID Type Subtype PubMed ID
esv2658029 CNV Deletion 23128226

Relevant External Links for PECR Gene

HapMap Linkage Disequilibrium report
PECR
Human Gene Mutation Database (HGMD)
PECR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PECR Gene

Disorders for PECR Gene

(1) University of Copenhagen DISEASES for PECR Gene

Relevant External Links for PECR

Genetic Association Database (GAD)
PECR
Human Genome Epidemiology (HuGE) Navigator
PECR
genes like me logo Genes that share disorders with PECR: view

No data available for UniProtKB/Swiss-Prot for PECR Gene

Publications for PECR Gene

  1. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. (PMID: 11937624) Braastad C.D. … Hendrickson E.A. (Nucleic Acids Res. 2002) 3 4 23
  2. Molecular cloning and expression of mammalian peroxisomal trans-2- enoyl-coenzyme A reductase cDNAs. (PMID: 10811639) Das A.K. … Hajra A.K. (J. Biol. Chem. 2000) 2 3 4
  3. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. (PMID: 11669066) Amery L. … Fransen M. (Comb. Chem. High Throughput Screen. 2001) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for PECR Gene

  • Addgene plasmids for PECR

Sources for PECR Gene

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