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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PECR Gene

protein-coding   GIFtS: 64
GCID: GC02M216867

Peroxisomal Trans-2-Enoyl-CoA Reductase

Microbiology & Infectious Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peroxisomal Trans-2-Enoyl-CoA Reductase1 2     DCRRP2
TERP2 3 5     HPDHASE2
2,4-Dienoyl-CoA Reductase-Related Protein2 3     HSA2503032
DCR-RP2 3     PVIARL2
pVI-ARL2 3     SDR29C12
EC 1.3.1.383 8     Putative Short Chain Alcohol Dehydrogenase2
Member 11     Short Chain Dehydrogenase/Reductase Family 29C, Member 12
Short Chain Dehydrogenase/Reductase Family 29C1     HPDHase3

External Ids:    HGNC: 182811   Entrez Gene: 558252   Ensembl: ENSG000001154257   OMIM: 6058435   UniProtKB: Q9BY493   

Export aliases for PECR gene to outside databases

Previous GC identifers: GC02M215065 GC02M215627 GC02M217105 GC02M216728 GC02M216611 GC02M208760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PECR Gene: 
PECR (peroxisomal trans-2-enoyl-CoA reductase) is a protein-coding gene. Diseases associated with PECR include alcoholism, and hirschsprung's disease, and among its related super-pathways are Fatty acid elongation and Fatty Acid Beta Oxidation. GO annotations related to this gene include 2,4-dienoyl-CoA reductase (NADPH) activity and nucleotide binding. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49
Function: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity

Gene Wiki entry for PECR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PECR gene promoter:
         LHX3b/Lhx3b   p53   p300   CUTL1   LCR-F1   C/EBPalpha   PPAR-alpha   IRF-2   LHX3a/Lhx3a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPECR promoter sequence
   Search SABiosciences Chromatin IP Primers for PECR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PECR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

PECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PECR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M216867:  view genomic region     (about GC identifiers)

Start:
216,861,052 bp from pter      End:
216,947,678 bp from pter
Size:
86,627 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49 (See protein sequence)
Recommended Name: Peroxisomal trans-2-enoyl-CoA reductase  
Size: 303 amino acids; 32544 Da
Subunit: Interacts with PEX5, probably required to target it into peroxisomes
Subcellular location: Peroxisome
Sequence caution: Sequence=AAF69798.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PECR:
1YXM (3D)    
Secondary accessions: B2RE42 Q53TC4 Q6IAK9 Q9NRD4 Q9NY60 Q9P1A4
Alternative splicing: 2 isoforms:  Q9BY49-1   Q9BY49-2   

Explore the universe of human proteins at neXtProt for PECR: NX_Q9BY49

Explore proteomics data for PECR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BY49

  • 2 DME Specific Peptides for PECR (Q9BY49)
     PDHDNWP  FLVNNGGGQF 

    PECR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PECR Protein Expression
    REFSEQ proteins: NP_060911.2  
    ENSEMBL proteins: 
     ENSP00000395512   ENSP00000265322  

    Human Recombinant Protein Products for PECR: 
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    Novus Biologicals PECR Proteins
    Novus Biologicals PECR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PECR
    Cloud-Clone Corp. Proteins for PECR 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA11669066
    GO:0005778peroxisomal membrane ISS10811639
    GO:0043231intracellular membrane-bounded organelle IDA--

    PECR for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    2 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BY49

    ProtoNet protein and cluster: Q9BY49

    3 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    PECR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PECR_HUMAN, Q9BY49
    Function: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity
    Catalytic activity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH
    Induction: Not induced by IR

         Enzyme Number (IUBMB): EC 1.3.1.381 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005102receptor binding IPI11669066
    GO:0008670NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA11669066
    GO:0016491oxidoreductase activity ----
    GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity IDA16546181
         
    PECR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PECR:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PECR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PECR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PECR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PECR 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate PECR:
    hsa-miR-183* hsa-miR-607 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidPECR 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PECR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PECR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    2Fatty Acid Beta Oxidation
    Mitochondrial LC-Fatty Acid Beta-Oxidation0.35
    3Fatty Acid Biosynthesis
    Fatty Acid Biosynthesis
    4Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for PECR
        Mitochondrial LC-Fatty Acid Beta-Oxidation
    Fatty Acid Biosynthesis


    2         Kegg Pathways  (Kegg details for PECR):
        Biosynthesis of unsaturated fatty acids
    Peroxisome

    UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49
    Pathway: Lipid metabolism; fatty acid biosynthesis


    PECR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PECR

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for PECR (Q9BY493 ENSP000002653224) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    SLC2A4P146723I2D: score=1 
    TECRENSP000002155674STRING: ENSP00000215567
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0033306phytol metabolic process IDA16546181
    GO:0044237cellular metabolic process ----
    GO:0055114oxidation-reduction process IDA16546181

    PECR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PECR

    10/36 HMDB Compounds for PECR (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    1 DrugBank Compound for PECR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenine1H-Purin-6-amine (see all 5)73-24-5target----

    Search CenterWatch for drugs/clinical trials and news about PECR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PECR gene: 
    NM_018441.5  

    Unigene Cluster for PECR:

    Peroxisomal trans-2-enoyl-CoA reductase
    Hs.281680  [show with all ESTs]
    Unigene Representative Sequence: AF232009
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442122(uc010zjq.2) ENST00000265322(uc002vft.3) ENST00000461330
    ENST00000464737 ENST00000497889 ENST00000487318 ENST00000474093 ENST00000464722

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PECR
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate PECR:
    hsa-miR-183* hsa-miR-607 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidPECR 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PECR (NM_018441)
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    Additional mRNA sequence: 

    AF212234.1 AF232009.1 AJ250303.1 AK296208.1 AK315795.1 BC002529.2 CR457145.1 

    7 DOTS entries:

    DT.40279231  DT.426559  DT.95269812  DT.101964097  DT.120945457  DT.91734627  DT.91767419 

    24/69 AceView cDNA sequences (see all 69):

    BG939782 AA332911 AI765848 BQ651276 AF212234 BF726019 AL525741 BE205792 
    CB163613 CR591404 CR615546 BQ645003 CR604406 BU151224 AI039989 CR457145 
    BX471043 BG742200 CB139848 AI245247 BG200900 AI382545 BM997383 AL523305 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PECR    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                    -                 -                                       
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for PECR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PECR expression in normal human tissues (normalized intensities)      PECR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACTGCAGT
    PECR Expression
    About this image


    PECR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See PECR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PECR

    SOURCE GeneReport for Unigene cluster: Hs.281680
        SABiosciences Expression via Pathway-Focused PCR Array including PECR: 
              Fatty Acid Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PECR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PECR gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pecr1 , 5 peroxisomal trans-2-enoyl-CoA reductase1, 5 77.34(n)1
    72.61(a)1
      1 (36.46 cM)5
    1111751  NM_023523.51  NP_076012.31 
     722591675 
    chicken
    (Gallus gallus)
    Aves PECR1 peroxisomal trans-2-enoyl-CoA reductase 65.22(n)
    62.82(a)
      424224  NM_001006522.1  NP_001006522.1 
    lizard
    (Anolis carolinensis)
    Reptilia PECR6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343344.1(905313-931840)
    zebrafish
    (Danio rerio)
    Actinopterygii pecr1 peroxisomal trans-2-enoyl-CoA reductase 60.73(n)
    58.56(a)
      550422  NM_001017727.1  NP_001017727.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPS196
    Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary e...
    30(a)
    1 → many
    XIV(259578-260456)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G292601 tropine dehydrogenase 46.28(n)
    35.54(a)
      817475  NM_128482.3  NP_180489.1 


    ENSEMBL Gene Tree for PECR (if available)
    TreeFam Gene Tree for PECR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PECR gene
    HPGD2  DCXR2  DECR22  CBR42  HSD17B142  DHRS22  HSD17B102  DHRS42  
    BDH22  DHRS4L22  HSD17B82  DECR12  
    8 SIMAP similar genes for PECR using alignment to 2 protein entries:     PECR_HUMAN (see all proteins):
    HSD17B12    DECR    PGDH    DECR1    DECR2    HPGD
    DHRS2    HSD17B14

    PECR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1053 SNPs in PECR are shown (see all 1053)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456205641,2
    --216902641(+) CATCTC/TTACTA 1 -- ds50010--------
    rs793735041,2
    C--216902642(+) ATCTCC/TACTAA 1 -- ds50010--------
    rs46740491,2
    C,F--216902675(+) TGGTGG/ATGCAC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1409530841,2
    --216902721(+) CAGAAA/TCACTT 1 -- ds50010--------
    rs134020521,2
    C,A--216902739(+) GGAGGC/TGGAGG 1 -- ds50012Minor allele frequency- T:0.25WA NA 4
    rs1406904411,2
    C--216902851(+) ATGAT-/AAAAAA 1 -- ds50010--------
    rs1388491371,2
    --216902875(+) ACTTCA/GCCTCA 1 -- ds50010--------
    rs1915713921,2
    --216902898(+) AACTTC/TGATTA 1 -- ds50010--------
    rs1837024181,2
    --216902938(+) AAAGGC/TATTTC 1 -- ds50010--------
    rs1492864251,2
    --216902974(+) TGGAGC/GCACGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PECR (216861052 - 216947678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PECR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658029CNV Deletion23128226


    Human Gene Mutation Database (HGMD): PECR
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PECR
    DNA2.0 Custom Variant and Variant Library Synthesis for PECR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605843    OMIM disorders: --

    6 diseases for PECR:    About MalaCards
    alcoholism    hirschsprung's disease    alcohol dependence    chronic obstructive pulmonary disease
    tuberculosis    pneumonia

    1 disease from the University of Copenhagen DISEASES database for PECR:
    Hirschsprung's disease

    PECR for disorders           About GeneDecksing

    Genetic Association Database (GAD): PECR
    Human Genome Epidemiology (HuGE) Navigator: PECR (1 document)

    Export disorders for PECR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PECR gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with PECR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. (PubMed id 11669066)1, 2, 3 Amery L....Fransen M. (2001)
    2. Molecular cloning and expression of mammalian peroxisomal trans-2- enoyl-coenzyme A reductase cDNAs. (PubMed id 10811639)1, 2, 3 Das A.K.... Hajra A.K. (2000)
    3. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. (PubMed id 11937624)1, 2, 9 Braastad C.D.... Hendrickson E.A. (2002)
    4. Multistudy fine mapping of chromosome 2q identifies X RCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PubMed id 20463177)1, 4 Hersh C.P....Silverman E.K. (2010)
    5. Genome-wide association study of alcohol dependence. (PubMed id 19581569)1, 4 Treutlein J....Rietschel M. (2009)
    6. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. (PubMed id 16546181)1, 9 Gloerich J....Wanders R.J. (2006)
    10. Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids. (PubMed id 22745130)1 Hua T.... Liu Z.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55825 HGNC: 18281 AceView: PECR Ensembl:ENSG00000115425 euGenes: HUgn55825
    ECgene: PECR Kegg: 55825 H-InvDB: PECR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PECR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PECR gene:
    Search GeneIP for patents involving PECR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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