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PECR Gene

protein-coding   GIFtS: 64
GCID: GC02M216867

Peroxisomal Trans-2-Enoyl-CoA Reductase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxisomal Trans-2-Enoyl-CoA Reductase1 2     DCRRP2
TERP2 3 5     HPDHASE2
2,4-Dienoyl-CoA Reductase-Related Protein2 3     HSA2503032
DCR-RP2 3     PVIARL2
pVI-ARL2 3     SDR29C12
EC 1.3.1.383 8     Putative Short Chain Alcohol Dehydrogenase2
Member 11     Short Chain Dehydrogenase/Reductase Family 29C, Member 12
Short Chain Dehydrogenase/Reductase Family 29C1     HPDHase3

External Ids:    HGNC: 182811   Entrez Gene: 558252   Ensembl: ENSG000001154257   OMIM: 6058435   UniProtKB: Q9BY493   

Export aliases for PECR gene to outside databases

Previous GC identifers: GC02M215065 GC02M215627 GC02M217105 GC02M216728 GC02M216611 GC02M208760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PECR Gene:
PECR (peroxisomal trans-2-enoyl-CoA reductase) is a protein-coding gene. Diseases associated with PECR include hirschsprung's disease, and alcohol dependence. GO annotations related to this gene include trans-2-enoyl-CoA reductase (NADPH) activity and receptor binding. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49
Function: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity

Gene Wiki entry for PECR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PECR gene promoter:
         LHX3b/Lhx3b   p53   p300   CUTL1   LCR-F1   C/EBPalpha   PPAR-alpha   IRF-2   LHX3a/Lhx3a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPECR promoter sequence
   Search Chromatin IP Primers for PECR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PECR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

PECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PECR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M216867:  view genomic region     (about GC identifiers)

Start:
216,861,052 bp from pter      End:
216,947,678 bp from pter
Size:
86,627 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49 (See protein sequence)
Recommended Name: Peroxisomal trans-2-enoyl-CoA reductase  
Size: 303 amino acids; 32544 Da
Subunit: Interacts with PEX5, probably required to target it into peroxisomes
Sequence caution: Sequence=AAF69798.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PECR:
1YXM (3D)    
Secondary accessions: B2RE42 Q53TC4 Q6IAK9 Q9NRD4 Q9NY60 Q9P1A4
Alternative splicing: 2 isoforms:  Q9BY49-1   Q9BY49-2   

Explore the universe of human proteins at neXtProt for PECR: NX_Q9BY49

Explore proteomics data for PECR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PECR (Q9BY49)
     PDHDNWP  FLVNNGGGQF 


    See PECR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060911.2  
    ENSEMBL proteins: 
     ENSP00000395512   ENSP00000265322  

    PECR Human Recombinant Protein Products:

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    PECR Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    2 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BY49

    ProtoNet protein and cluster: Q9BY49

    3 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    PECR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PECR_HUMAN, Q9BY49
    Function: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity
    Catalytic activity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH
    Induction: Not induced by IR

         Enzyme Number (IUBMB): EC 1.3.1.381 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005102receptor binding IPI11669066
    GO:0008670NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA11669066
    GO:0016491oxidoreductase activity ----
    GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity IDA16546181
         
    PECR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PECR:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PECR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PECR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PECR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PECR

    miRNA
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    miRTarBase miRNAs that target PECR:
    hsa-mir-124-3p (MIRT023047)

    Block miRNA regulation of human, mouse, rat PECR using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PECR:
    hsa-miR-183* hsa-miR-607 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidPECR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PECR

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PECR (NM_018441)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PECR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PECR

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PECR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PECR_HUMAN, Q9BY49: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol2
    mitochondrion2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA11669066
    GO:0005778peroxisomal membrane ISS10811639
    GO:0043231intracellular membrane-bounded organelle IDA--

    PECR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PECR About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid metabolism
    Fatty acid metabolism0.42
    2Biosynthesis of unsaturated fatty acids
    Biosynthesis of unsaturated fatty acids0.38
    3Mitochondrial LC-Fatty Acid Beta-Oxidation
    Mitochondrial LC-Fatty Acid Beta-Oxidation0.35
    4Peroxisome
    Peroxisome
    5Fatty Acid Biosynthesis
    Fatty Acid Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for PECR
        Mitochondrial LC-Fatty Acid Beta-Oxidation
    Fatty Acid Biosynthesis


    3 Kegg Pathways  (Kegg details for PECR):
        Biosynthesis of unsaturated fatty acids
    Fatty acid metabolism
    Peroxisome

    UniProtKB/Swiss-Prot: PECR_HUMAN, Q9BY49
    Pathway: Lipid metabolism; fatty acid biosynthesis


    PECR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PECR: 

              Fatty Acid Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PECR

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for PECR (Q9BY493 ENSP000002653224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    SLC2A4P146723I2D: score=1 
    TECRENSP000002155674STRING: ENSP00000215567
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0033306phytol metabolic process IDA16546181
    GO:0044237cellular metabolic process ----
    GO:0055114oxidation-reduction process IDA16546181

    PECR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PECR

    Selected HMDB Compounds for PECR (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    1 DrugBank Compound for PECR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenine1H-Purin-6-amine (see all 5)73-24-5target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PECR gene: 
    NM_018441.5  

    Unigene Cluster for PECR:

    Peroxisomal trans-2-enoyl-CoA reductase
    Hs.281680  [show with all ESTs]
    Unigene Representative Sequence: AF232009
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442122(uc010zjq.2) ENST00000265322(uc002vft.3) ENST00000461330
    ENST00000464737 ENST00000497889 ENST00000487318 ENST00000474093 ENST00000464722

    miRNA
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    Block miRNA regulation of human, mouse, rat PECR using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PECR:
    hsa-miR-183* hsa-miR-607 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidPECR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PECR
    Predesigned siRNA for gene silencing in human, mouse, rat PECR
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PECR (NM_018441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PECR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PECR
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PECR
      QuantiTect SYBR Green Assays in human, mouse, rat PECR
      QuantiFast Probe-based Assays in human, mouse, rat PECR

    Additional mRNA sequence: 

    AF212234.1 AF232009.1 AJ250303.1 AK296208.1 AK315795.1 BC002529.2 CR457145.1 

    7 DOTS entries:

    DT.40279231  DT.426559  DT.95269812  DT.101964097  DT.120945457  DT.91734627  DT.91767419 

    Selected AceView cDNA sequences (see all 69):

    BE205792 AA332911 CB163613 BG939782 BQ651276 CR615546 AL525741 AI765848 
    BF726019 BU151224 AF212234 CR604406 BQ645003 CR591404 CR457145 BM314509 
    AL523305 BG742350 AA232159 AF232009 CB139848 BG774814 AI245247 BI836198 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PECR    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                    -                 -                                       
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for PECR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PECR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACTGCAGT
    PECR Expression
    About this image


    PECR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PECR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PECR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.281680
        Pathway & Disease-focused RT2 Profiler PCR Array including PECR: 
              Fatty Acid Metabolism in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PECR
    OriGene qSTAR qPCR primer pairs in human, mouse for PECR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PECR
    QuantiTect SYBR Green Assays in human, mouse, rat PECR
    QuantiFast Probe-based Assays in human, mouse, rat PECR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PECR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PECR gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pecr1 , 5 peroxisomal trans-2-enoyl-CoA reductase1, 5 77.34(n)1
    72.61(a)1
      1 (36.46 cM)5
    1111751  NM_023523.51  NP_076012.31 
     722591675 
    chicken
    (Gallus gallus)
    Aves PECR1 peroxisomal trans-2-enoyl-CoA reductase 65.22(n)
    62.82(a)
      424224  NM_001006522.1  NP_001006522.1 
    lizard
    (Anolis carolinensis)
    Reptilia PECR6
    peroxisomal trans-2-enoyl-CoA reductase
    62(a)
    1 ↔ 1
    GL343344.1(905313-931840)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pecr1 peroxisomal trans-2-enoyl-CoA reductase 62.17(n)
    62.3(a)
      496922  XM_002942007.2  XP_002942053.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pecr1 peroxisomal trans-2-enoyl-CoA reductase 60.73(n)
    58.56(a)
      550422  NM_001017727.1  NP_001017727.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPS196
    Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary e...
    32(a)
    1 → many
    XIV(259578-260456) YNL202W
    rice
    (Oryza sativa)
    Liliopsida Os11g04437001 Os11g0443700 49.58(n)
    40.42(a)
      4350428  NM_001074351.1  NP_001067819.1 


    ENSEMBL Gene Tree for PECR (if available)
    TreeFam Gene Tree for PECR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for PECR gene
    HPGD2  DCXR2  DECR22  CBR42  HSD17B142  DHRS22  HSD17B102  DHRS42  
    BDH22  DHRS4L22  HSD17B82  DECR12  
    7 SIMAP similar genes for PECR using alignment to 2 protein entries:     PECR_HUMAN (see all proteins):
    HSD17B12    DECR    PGDH    DECR1    DECR2    HPGD
    HSD17B14

    PECR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PECR (see all 1053)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456205641,2
    --216902641(+) CATCTC/TTACTA 1 -- ds50010--------
    rs793735041,2
    C--216902642(+) ATCTCC/TACTAA 1 -- ds50010--------
    rs46740491,2
    C,F--216902675(+) TGGTGG/ATGCAC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1409530841,2
    --216902721(+) CAGAAA/TCACTT 1 -- ds50010--------
    rs134020521,2
    C,A--216902739(+) GGAGGC/TGGAGG 1 -- ds50012Minor allele frequency- T:0.25WA NA 4
    rs1406904411,2
    C--216902851(+) ATGAT-/AAAAAA 1 -- ds50010--------
    rs1388491371,2
    --216902875(+) ACTTCA/GCCTCA 1 -- ds50010--------
    rs1915713921,2
    --216902898(+) AACTTC/TGATTA 1 -- ds50010--------
    rs1837024181,2
    --216902938(+) AAAGGC/TATTTC 1 -- ds50010--------
    rs1492864251,2
    --216902974(+) TGGAGC/GCACGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PECR (216861052 - 216947678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PECR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658029CNV Deletion23128226

    Human Gene Mutation Database (HGMD): PECR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PECR
    DNA2.0 Custom Variant and Variant Library Synthesis for PECR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605843    OMIM disorders: --

    9 diseases for PECR:    
    About MalaCards
    hirschsprung's disease    alcohol dependence    tonsillitis    pneumonia
    tuberculosis    thyroiditis    cerebritis    endotheliitis
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PECR:
    Hirschsprung's disease

    PECR for disorders           About GeneDecksing

    Genetic Association Database (GAD): PECR
    Human Genome Epidemiology (HuGE) Navigator: PECR (1 document)

    Export disorders for PECR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PECR gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with PECR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. (PubMed id 11669066)1, 2, 3 Amery L....Fransen M. (Comb. Chem. High Throughput Screen. 2001)
    2. Molecular cloning and expression of mammalian peroxisomal trans-2- enoyl-coenzyme A reductase cDNAs. (PubMed id 10811639)1, 2, 3 Das A.K.... Hajra A.K. (J. Biol. Chem. 2000)
    3. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. (PubMed id 11937624)1, 2, 9 Braastad C.D.... Hendrickson E.A. (Nucleic Acids Res. 2002)
    4. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PubMed id 20463177)1, 4 Hersh C.P....Silverman E.K. (Am. J. Respir. Crit. Care Med. 2010)
    5. Genome-wide association study of alcohol dependence. (PubMed id 19581569)1, 4 Treutlein J....Rietschel M. (Arch. Gen. Psychiatry 2009)
    6. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. (PubMed id 16546181)1, 9 Gloerich J....Wanders R.J. (FEBS Lett. 2006)
    10. Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids. (PubMed id 22745130)1 Hua T.... Liu Z.J. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55825 HGNC: 18281 AceView: PECR Ensembl:ENSG00000115425 euGenes: HUgn55825
    ECgene: PECR Kegg: 55825 H-InvDB: PECR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PECR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PECR gene:
    Search GeneIP for patents involving PECR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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