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Aliases for PECAM1 Gene

Aliases for PECAM1 Gene

  • Platelet/Endothelial Cell Adhesion Molecule 1 2 3
  • CD31 Antigen 2 3 4
  • EndoCAM 3 4
  • PECAM-1 3 4
  • GPIIA 3 4
  • PECA1 3 4
  • Platelet/Endothelial Cell Adhesion Molecule 2
  • CD31/EndoCAM 3
  • CD31 3

External Ids for PECAM1 Gene

Previous GeneCards Identifiers for PECAM1 Gene

  • GC17U990071
  • GC17M064827
  • GC17M062740
  • GC17M062873
  • GC17M059754
  • GC17M062399

Summaries for PECAM1 Gene

Entrez Gene Summary for PECAM1 Gene

  • The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

GeneCards Summary for PECAM1 Gene

PECAM1 (Platelet/Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include pulmonary vein stenosis and idiopathic membranous glomerulonephritis. Among its related pathways are Angiogenesis (CST) and Integrin Pathway.

UniProtKB/Swiss-Prot for PECAM1 Gene

  • Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Gene Wiki entry for PECAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PECAM1 Gene

Genomics for PECAM1 Gene

Regulatory Elements for PECAM1 Gene

Genomic Location for PECAM1 Gene

Chromosome:
17
Start:
64,319,415 bp from pter
End:
64,413,801 bp from pter
Size:
94,387 bases
Orientation:
Minus strand

Genomic View for PECAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PECAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PECAM1 Gene

Proteins for PECAM1 Gene

  • Protein details for PECAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16284-PECA1_HUMAN
    Recommended name:
    Platelet endothelial cell adhesion molecule
    Protein Accession:
    P16284
    Secondary Accessions:
    • A8K3S7
    • D3DU31
    • Q6LDA9
    • Q8TBH1
    • Q96RF5
    • Q96RF6
    • Q9NP65
    • Q9NPB7
    • Q9NPG9
    • Q9NQS9
    • Q9NQT0
    • Q9NQT1
    • Q9NQT2

    Protein attributes for PECAM1 Gene

    Size:
    738 amino acids
    Molecular mass:
    82536 Da
    Quaternary structure:
    • Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

    Three dimensional structures from OCA and Proteopedia for PECAM1 Gene

    Alternative splice isoforms for PECAM1 Gene

neXtProt entry for PECAM1 Gene

Proteomics data for PECAM1 Gene at MOPED

Post-translational modifications for PECAM1 Gene

  • Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells.
  • Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.
  • Ubiquitination at Lys 446 and Lys 543
  • Glycosylation at Asn 52, Asn 84, Asn 151, Asn 301, Asn 320, Asn 344, Asn 356, Asn 453, and Asn 551
  • Modification sites at PhosphoSitePlus

Other Protein References for PECAM1 Gene

No data available for DME Specific Peptides for PECAM1 Gene

Domains & Families for PECAM1 Gene

Gene Families for PECAM1 Gene

Protein Domains for PECAM1 Gene

Suggested Antigen Peptide Sequences for PECAM1 Gene

Graphical View of Domain Structure for InterPro Entry

P16284

UniProtKB/Swiss-Prot:

PECA1_HUMAN :
  • The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity
Domain:
  • The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PECAM1: view

Function for PECAM1 Gene

Molecular function for PECAM1 Gene

GENATLAS Biochemistry:
platelet endothelial cell adhesion molecule 1,immunoglobulin superfamily,expressed on circulating platelets,monocytes,neutrophils,subsets of T cells,also a major constituent of the endothelial intercellular cell junction
UniProtKB/Swiss-Prot Function:
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Gene Ontology (GO) - Molecular Function for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9162084
genes like me logo Genes that share ontologies with PECAM1: view
genes like me logo Genes that share phenotypes with PECAM1: view

Animal Models for PECAM1 Gene

MGI Knock Outs for PECAM1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PECAM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for PECAM1 Gene

Localization for PECAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PECAM1 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Gene Ontology (GO) - Cellular Components for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PECAM1: view

No data available for Subcellular locations from COMPARTMENTS for PECAM1 Gene

Pathways & Interactions for PECAM1 Gene

genes like me logo Genes that share pathways with PECAM1: view

Pathways by source for PECAM1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006909 phagocytosis IDA 12110892
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 7994021
GO:0007266 Rho protein signal transduction --
genes like me logo Genes that share ontologies with PECAM1: view

No data available for SIGNOR curated interactions for PECAM1 Gene

Drugs & Compounds for PECAM1 Gene

(25) Drugs for PECAM1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 971
Carbimazole Approved Pharma 2
Heparin Approved, Investigational Pharma Antagonist 672,226
Nitric Oxide Approved Pharma 540
Prasugrel Approved Pharma ADP receptor inhibitor 160

(35) Additional Compounds for PECAM1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5 Aminosalicylic Acid
Actinomycin D
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Agar
Cycloheximide
genes like me logo Genes that share compounds with PECAM1: view

Transcripts for PECAM1 Gene

Unigene Clusters for PECAM1 Gene

Platelet/endothelial cell adhesion molecule 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PECAM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PECAM1 Gene

No ASD Table

Relevant External Links for PECAM1 Gene

GeneLoc Exon Structure for
PECAM1
ECgene alternative splicing isoforms for
PECAM1

Expression for PECAM1 Gene

mRNA expression in normal human tissues for PECAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PECAM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.6) and Platelet (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PECAM1 Gene



SOURCE GeneReport for Unigene cluster for PECAM1 Gene Hs.376675

mRNA Expression by UniProt/SwissProt for PECAM1 Gene

P16284-PECA1_HUMAN
Tissue specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).
genes like me logo Genes that share expression patterns with PECAM1: view

Protein tissue co-expression partners for PECAM1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PECAM1 Gene

Orthologs for PECAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PECAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PECAM1 35
  • 78.61 (n)
  • 70.69 (a)
dog
(Canis familiaris)
Mammalia PECAM1 35
  • 81.28 (n)
  • 72.46 (a)
mouse
(Mus musculus)
Mammalia Pecam1 35
  • 73.48 (n)
  • 64.32 (a)
Pecam1 16
chimpanzee
(Pan troglodytes)
Mammalia PECAM1 35
  • 99.19 (n)
  • 99.32 (a)
rat
(Rattus norvegicus)
Mammalia Pecam1 35
  • 73.88 (n)
  • 66.11 (a)
chicken
(Gallus gallus)
Aves PECAM1 35
  • 51.12 (n)
  • 35.66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493686 35
  • 45.85 (n)
  • 33.89 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-237i9.8 35
  • 44.44 (n)
  • 30.45 (a)
Species with no ortholog for PECAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PECAM1 Gene

ENSEMBL:
Gene Tree for PECAM1 (if available)
TreeFam:
Gene Tree for PECAM1 (if available)

Paralogs for PECAM1 Gene

Pseudogenes.org Pseudogenes for PECAM1 Gene

genes like me logo Genes that share paralogs with PECAM1: view

No data available for Paralogs for PECAM1 Gene

Variants for PECAM1 Gene

Sequence variations from dbSNP and Humsavar for PECAM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2812 -- 64,323,758(-) CAGAT(A/G)ATCCC utr-variant-3-prime
rs6808 -- 64,323,215(-) GACAC(A/C/G)GTTCA utr-variant-3-prime
rs6809 -- 64,323,350(-) TTTGG(C/G)TAGTC utr-variant-3-prime
rs12953 -, - 64,356,203(-) GGCTA(A/G/T)CAAGG missense, reference
rs954507 -- 64,329,971(+) ttttt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PECAM1 Gene

Variant ID Type Subtype PubMed ID
nsv524852 CNV Gain 19592680

Relevant External Links for PECAM1 Gene

HapMap Linkage Disequilibrium report
PECAM1
Human Gene Mutation Database (HGMD)
PECAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PECAM1 Gene

Disorders for PECAM1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for PECAM1 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
pulmonary vein stenosis
  • pulmonary veins stenosis
idiopathic membranous glomerulonephritis
erythema elevatum diutinum
capillary hemangioma
  • congenital vascular naevus
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
- elite association

Relevant External Links for PECAM1

Genetic Association Database (GAD)
PECAM1
Human Genome Epidemiology (HuGE) Navigator
PECAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PECAM1
genes like me logo Genes that share disorders with PECAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PECAM1 Gene

Publications for PECAM1 Gene

  1. Cell aggregation induces phosphorylation of PECAM-1 and Pyk2 and promotes tumor cell anchorage-independent growth. (PMID: 20074345) Zhang X. … Yu Q. (Mol. Cancer 2010) 23 67
  2. Efficient inhibition of non-small-cell lung cancer xenograft by systemic delivery of plasmid-encoding short-hairpin RNA targeting VEGF. (PMID: 20187798) Yang Y. … Deng H.X. (Cancer Biother. Radiopharm. 2010) 23 67
  3. Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1. (PMID: 20194726) Bayat B. … Santoso S. (J. Immunol. 2010) 23 67
  4. Molecular evaluation of circulating endothelial progenitor cells in children undergoing hemodialysis and after kidney transplantation. (PMID: 18852688) Metsuyanim S. … Dekel B. (Pediatr. Res. 2009) 23 67
  5. Incorporation of endothelial progenitor cells into the neovasculature of malignant glioma xenograft. (PMID: 19052696) Zhang H.R. … Bian X.W. (J. Neurooncol. 2009) 23 67

Products for PECAM1 Gene

Sources for PECAM1 Gene

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