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Aliases for PECAM1 Gene

Aliases for PECAM1 Gene

  • Platelet And Endothelial Cell Adhesion Molecule 1 2 3 5
  • CD31 Antigen 2 3 4
  • EndoCAM 3 4
  • PECAM-1 3 4
  • GPIIA 3 4
  • PECA1 3 4
  • Platelet/Endothelial Cell Adhesion Molecule 1 2
  • Platelet Endothelial Cell Adhesion Molecule-1 3
  • Platelet Endothelial Cell Adhesion Molecule 3
  • CD31/EndoCAM 3
  • CD31 3

External Ids for PECAM1 Gene

Previous GeneCards Identifiers for PECAM1 Gene

  • GC17U990071
  • GC17M064827
  • GC17M062740
  • GC17M062873
  • GC17M059754
  • GC17M062399

Summaries for PECAM1 Gene

Entrez Gene Summary for PECAM1 Gene

  • The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

GeneCards Summary for PECAM1 Gene

PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Radiation Proctitis and Pulmonary Vein Stenosis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall.

UniProtKB/Swiss-Prot for PECAM1 Gene

  • Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Gene Wiki entry for PECAM1 Gene

Additional gene information for PECAM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PECAM1 Gene

Genomics for PECAM1 Gene

Regulatory Elements for PECAM1 Gene

Enhancers for PECAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H064090 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +321.9 321876 1 ZNF687 JUNB MAX BATF YY1 EED IKZF1 ETV6 RUNX3 IKZF2 PECAM1 ERN1 MAP3K3 DDX5 LIMD2 ICAM2 GC17M064041
GH17H064326 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +85.8 85833 4 ELF3 HDGF TBP PKNOX1 ZSCAN9 RARA YY1 ELK1 RUNX3 ELK4 PECAM1 ERN1 DDX5 GC17M064322 ENSG00000239823
GH17H064079 2 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +330.9 330946 6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B ERN1 CSHL1 GH1 SNORD104 MAP3K3 PECAM1 DDX5 PRR29 LIMD2 ICAM2
GH17H064330 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +81.1 81101 3 PKNOX1 ATF1 FOXA2 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 ZNF592 PECAM1 LRRC37A3 ERN1 DDX5 ICAM2 GC17M064322 ENSG00000239823
GH17H064055 1.3 FANTOM5 ENCODE dbSUPER 7 +357.4 357418 1 CTCF PKNOX1 MAX EBF1 EED ZNF143 ETV6 ATF7 RUNX3 IKZF2 ERN1 GH1 CSHL1 SNORD104 PECAM1 MAP3K3 LIMD2 DDX5 GC17M064041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PECAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PECAM1 Gene

Chromosome:
17
Start:
64,319,415 bp from pter
End:
64,413,801 bp from pter
Size:
94,387 bases
Orientation:
Minus strand

Genomic View for PECAM1 Gene

Genes around PECAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PECAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PECAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PECAM1 Gene

Proteins for PECAM1 Gene

  • Protein details for PECAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16284-PECA1_HUMAN
    Recommended name:
    Platelet endothelial cell adhesion molecule
    Protein Accession:
    P16284
    Secondary Accessions:
    • A8K3S7
    • D3DU31
    • Q6LDA9
    • Q8TBH1
    • Q96RF5
    • Q96RF6
    • Q9NP65
    • Q9NPB7
    • Q9NPG9
    • Q9NQS9
    • Q9NQT0
    • Q9NQT1
    • Q9NQT2

    Protein attributes for PECAM1 Gene

    Size:
    738 amino acids
    Molecular mass:
    82536 Da
    Quaternary structure:
    • Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

    Three dimensional structures from OCA and Proteopedia for PECAM1 Gene

    Alternative splice isoforms for PECAM1 Gene

neXtProt entry for PECAM1 Gene

Post-translational modifications for PECAM1 Gene

  • Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.
  • Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.
  • Ubiquitination at Lys446 and Lys543
  • Glycosylation at posLast=5252, posLast=8484, posLast=151151, posLast=301301, posLast=320320, posLast=344344, Asn356, posLast=453453, and Asn551
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PECAM1 (CD31/PECAM-1)
  • Cell Signaling Technology (CST) Antibodies for PECAM1 (PECAM-1)

Assay Products

  • Cloud-Clone Corp. Assay Kits for PECAM1

No data available for DME Specific Peptides for PECAM1 Gene

Domains & Families for PECAM1 Gene

Gene Families for PECAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PECAM1 Gene

Suggested Antigen Peptide Sequences for PECAM1 Gene

Graphical View of Domain Structure for InterPro Entry

P16284

UniProtKB/Swiss-Prot:

PECA1_HUMAN :
  • The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.
Domain:
  • The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.
genes like me logo Genes that share domains with PECAM1: view

Function for PECAM1 Gene

Molecular function for PECAM1 Gene

GENATLAS Biochemistry:
platelet endothelial cell adhesion molecule 1,immunoglobulin superfamily,expressed on circulating platelets,monocytes,neutrophils,subsets of T cells,also a major constituent of the endothelial intercellular cell junction
UniProtKB/Swiss-Prot Function:
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Phenotypes From GWAS Catalog for PECAM1 Gene

Gene Ontology (GO) - Molecular Function for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9162084
genes like me logo Genes that share ontologies with PECAM1: view
genes like me logo Genes that share phenotypes with PECAM1: view

Animal Models for PECAM1 Gene

MGI Knock Outs for PECAM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PECAM1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PECAM1 Gene

Localization for PECAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PECAM1 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. {ECO:0000269 PubMed:19342684}.
Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Gene Ontology (GO) - Cellular Components for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane IEA,TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PECAM1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PECAM1 Gene

Pathways & Interactions for PECAM1 Gene

genes like me logo Genes that share pathways with PECAM1: view

Pathways by source for PECAM1 Gene

Gene Ontology (GO) - Biological Process for PECAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0002576 platelet degranulation TAS --
GO:0006909 phagocytosis IDA 12110892
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 7994021
genes like me logo Genes that share ontologies with PECAM1: view

No data available for SIGNOR curated interactions for PECAM1 Gene

Drugs & Compounds for PECAM1 Gene

(29) Drugs for PECAM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(31) Additional Compounds for PECAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PECAM1: view

Transcripts for PECAM1 Gene

Unigene Clusters for PECAM1 Gene

Platelet/endothelial cell adhesion molecule 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PECAM1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PECAM1 Gene

No ASD Table

Relevant External Links for PECAM1 Gene

GeneLoc Exon Structure for
PECAM1
ECgene alternative splicing isoforms for
PECAM1

Expression for PECAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PECAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PECAM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.6) and Platelet (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PECAM1 Gene



Protein tissue co-expression partners for PECAM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PECAM1 Gene:

PECAM1

SOURCE GeneReport for Unigene cluster for PECAM1 Gene:

Hs.376675

mRNA Expression by UniProt/SwissProt for PECAM1 Gene:

P16284-PECA1_HUMAN
Tissue specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).
genes like me logo Genes that share expression patterns with PECAM1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PECAM1 Gene

Orthologs for PECAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PECAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PECAM1 33
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia PECAM1 33
  • 81.28 (n)
cow
(Bos Taurus)
Mammalia PECAM1 33
  • 78.61 (n)
rat
(Rattus norvegicus)
Mammalia Pecam1 33
  • 73.88 (n)
mouse
(Mus musculus)
Mammalia Pecam1 33 16
  • 73.48 (n)
chicken
(Gallus gallus)
Aves PECAM1 33
  • 51.12 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493686 33
  • 45.85 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-237i9.8 33
  • 44.44 (n)
Species where no ortholog for PECAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PECAM1 Gene

ENSEMBL:
Gene Tree for PECAM1 (if available)
TreeFam:
Gene Tree for PECAM1 (if available)

Paralogs for PECAM1 Gene

Pseudogenes.org Pseudogenes for PECAM1 Gene

genes like me logo Genes that share paralogs with PECAM1: view

No data available for Paralogs for PECAM1 Gene

Variants for PECAM1 Gene

Sequence variations from dbSNP and Humsavar for PECAM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs281865545 untested 64,377,836(-) ACCAG(C/G)TGTTG reference, missense
rs1000005697 -- 64,407,775(+) CCTGG(A/G)GGAGG intron-variant
rs1000014480 -- 64,374,139(+) CAGTG(G/T)CTTCC intron-variant
rs1000016209 -- 64,415,579(+) GGCAT(A/G)GGCCA upstream-variant-2KB
rs1000036870 -- 64,408,183(+) TGCAT(A/C)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PECAM1 Gene

Variant ID Type Subtype PubMed ID
esv1046865 CNV insertion 17803354
esv990152 CNV insertion 20482838
nsv1066968 CNV gain 25217958
nsv2118 CNV insertion 18451855
nsv2119 CNV insertion 18451855
nsv480729 CNV novel sequence insertion 20440878
nsv481581 CNV novel sequence insertion 20440878
nsv507853 OTHER sequence alteration 20534489
nsv509666 CNV insertion 20534489
nsv511058 OTHER complex 20534489
nsv524852 CNV gain 19592680
nsv833512 CNV gain+loss 17160897
nsv833513 CNV loss 17160897

Relevant External Links for PECAM1 Gene

Human Gene Mutation Database (HGMD)
PECAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PECAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PECAM1 Gene

Disorders for PECAM1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for PECAM1 Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
radiation proctitis
pulmonary vein stenosis
  • pulmonary veins stenosis
erythema elevatum diutinum
capillary hemangioma
  • cellular hemangioma of infancy
angiosarcoma
  • hemangiosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PECAM1

Genetic Association Database (GAD)
PECAM1
Human Genome Epidemiology (HuGE) Navigator
PECAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PECAM1
genes like me logo Genes that share disorders with PECAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PECAM1 Gene

Publications for PECAM1 Gene

  1. Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with ischemic stroke. (PMID: 19183069) Wei YS … Xie HY (DNA and cell biology 2009) 3 22 45 60
  2. A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration. (PMID: 19342684) Dasgupta B … Muller WA (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 22 60
  3. [Study of association of platelet endothelial cell adhesion molecule-1 gene polymorphism with acute myocardial infarction]. (PMID: 19570335) Fu XL … Xia ZH (Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 2009) 3 22 45 60
  4. Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1. (PMID: 18672896) Yeh JC … Frangos JA (Biochemistry 2008) 3 4 22 60
  5. Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation. (PMID: 18710921) Chiu YJ … Fujiwara K (The Journal of cell biology 2008) 3 4 22 60

Products for PECAM1 Gene

Sources for PECAM1 Gene

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