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PECAM1 Gene

protein-coding   GIFtS: 61
GCID: GC17M062399

Platelet/Endothelial Cell Adhesion Molecule 1

(Previous name: platelet/endothelial cell adhesion molecule)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet/Endothelial Cell Adhesion Molecule 11 2     CD312
CD31 Antigen1 2 3     CD31/EndoCAM2
GPIIA'2 3     endoCAM2
PECA12 3     Platelet Endothelial Cell Adhesion Molecule2
PECAM-12 3     EndoCAM3
Platelet/Endothelial Cell Adhesion Molecule1     

External Ids:    HGNC: 88231   Entrez Gene: 51752   OMIM: 1734455   UniProtKB: P162843   

Export aliases for PECAM1 gene to outside databases

Previous GC identifers: GC17U990071 GC17M064827 GC17M062740 GC17M062873 GC17M059754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PECAM1 Gene:
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of
T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a
member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and
integrin activation. (provided by RefSeq, May 2010)

GeneCards Summary for PECAM1 Gene:
PECAM1 (platelet/endothelial cell adhesion molecule 1) is a protein-coding gene. Diseases associated with PECAM1 include angiosarcoma, and erythema elevatum diutinum.

UniProtKB/Swiss-Prot: PECA1_HUMAN, P16284
Function: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for
leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in
TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment
(LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte
ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on
apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via
the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the
phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell
does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction
of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the
phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis.
Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human
umbilical cord vein cells (HUVEC)

Gene Wiki entry for PECAM1 (CD31) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PECAM1 gene promoter:
         STAT1   FOXO3   HNF-3beta   FOXO3b   NRF-2   FOXO4   COMP1   FOXO1a   FOXO3a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPECAM1 promoter sequence
   Search Chromatin IP Primers for PECAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PECAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   HGNC cytogenetic band: 17q23.3

PECAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PECAM1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M062399:  view genomic region     (about GC identifiers)

Start:
62,396,775 bp from pter      End:
62,404,856 bp from pter
Size:
8,082 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003315947 123,262-194,725     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PECA1_HUMAN, P16284 (See protein sequence)
Recommended Name: Platelet endothelial cell adhesion molecule precursor  
Size: 738 amino acids; 82536 Da
Subunit: Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ.
Interacts with BDKRB2 and GNAQ
1 PDB 3D structure from and Proteopedia for PECAM1:
2KY5 (3D)    
Secondary accessions: A8K3S7 D3DU31 Q6LDA9 Q8TBH1 Q96RF5 Q96RF6 Q9NP65 Q9NPB7 Q9NPG9 Q9NQS9
Q9NQT0 Q9NQT1 Q9NQT2
Alternative splicing: 6 isoforms:  P16284-1   P16284-2   P16284-3   P16284-4   P16284-5   P16284-6   

Explore the universe of human proteins at neXtProt for PECAM1: NX_P16284

Explore proteomics data for PECAM1 at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and
    FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch
    or pull) induced tyrosine phosphorylation1
  • Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells1
  • Ubiquitination2 at Lys446, Lys543
  • Glycosylation2 at Asn52, Asn84, Asn151, Asn301, Asn320, Asn344, Asn356, Asn453, Asn551
  • Modification sites at PhosphoSitePlus

  • See PECAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000433.4  Reactome Protein details: P16284

    PECAM1 Human Recombinant Protein Products:

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    Novus Biologicals PECAM1 Proteins
    Novus Biologicals PECAM1 Lysates
    Sino Biological Recombinant Protein for PECAM1
    Sino Biological Cell Lysate for PECAM1
    ProSpec Recombinant Protein for PECAM1
    Cloud-Clone Corp. Proteins for PECAM1

    PECAM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PECAM1
    R&D Systems Antibodies for PECAM1 (CD31/PECAM-1)
    Cell Signaling Technology (CST) Antibodies for PECAM1  (PECAM-1)
    OriGene Antibodies for PECAM1
    OriGene Custom Antibody Services for PECAM1
    Novus Biologicals PECAM1 Antibodies
    Abcam antibodies for PECAM1
    Cloud-Clone Corp. Antibodies for PECAM1
    ThermoFisher Antibody for PECAM1
    LSBio Antibodies in human, mouse, rat for PECAM1

    PECAM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PECAM1
    R&D Systems ELISAs for PECAM1 (CD31/PECAM-1)         (see all)
    GenScript Custom Assay Services for PECAM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PECAM1
    Cloud-Clone Corp. CLIAs for PECAM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P16284

    ProtoNet protein and cluster: P16284

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: PECA1_HUMAN, P16284
    Domain: The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation
    of its activity
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    PECAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PECA1_HUMAN, P16284
    Function: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for
    leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in
    TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment
    (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte
    ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on
    apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via
    the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the
    phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell
    does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction
    of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the
    phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis.
    Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human
    umbilical cord vein cells (HUVEC)

         Genatlas biochemistry entry for PECAM1:
    platelet endothelial cell adhesion molecule 1,immunoglobulin superfamily,expressed on circulating
    platelets,monocytes,neutrophils,subsets of T cells,also a major constituent of the endothelial intercellular cell
    junction

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10704309
         
    PECAM1 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pecam1):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  muscle  renal/urinary system  respiratory system 
     skeleton 

    PECAM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pecam1tm1Mak for PECAM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PECAM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PECAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PECAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PECAM1

    miRNA
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    Block miRNA regulation of human, mouse, rat PECAM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PECAM1 (see all 24):
    hsa-miR-4291 hsa-miR-3614-3p hsa-miR-4272 hsa-miR-519a hsa-miR-3916 hsa-miR-3125 hsa-miR-1297 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidPECAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PECAM1
    Predesigned siRNA for gene silencing in human, mouse, rat PECAM1

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PECAM1 (NM_000442)
    Sino Biological Human cDNA Clone for PECAM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PECAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PECAM1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PECAM1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PECAM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PECA1_HUMAN, P16284: Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane;
    Lipid-anchor. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from
    the LBRC to the junction in resting endothelial cells
    PECA1_HUMAN, P16284: Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment
    (LBRC) and recycles from the LBRC to the junction in resting endothelial cells

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA9290466
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0031092platelet alpha granule membrane TAS--

    PECAM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PECAM1 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    3Platelet homeostasis
    Platelet sensitization by LDL0.00
    Platelet homeostasis
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    PECAM1 interactions0.00
    5Integrin Pathway
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PECAM1
        Transendothelial Migration of Leukocytes

    2 Cell Signaling Technology (CST) Pathways for PECAM1
        Angiogenesis
    Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for PECAM1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms


    5 Reactome Pathways for PECAM1
        Integrin cell surface interactions
    Platelet degranulation
    PECAM1 interactions
    Cell surface interactions at the vascular wall
    Platelet sensitization by LDL


    3 Kegg Pathways  (Kegg details for PECAM1):
        Cell adhesion molecules (CAMs)
    Leukocyte transendothelial migration
    Malaria


    PECAM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PECAM1 (see all 8): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PECAM1

    Selected Interacting proteins for PECAM1 (P162841, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061241, 2, 3EBI-716404,EBI-297779 MINT-8031324 MINT-8031354 MINT-8031339 MINT-8033295 MINT-8033235 MINT-8033280 MINT-8033310 I2D: score=3 
    PTPN6P293501, 2, 3EBI-716404,EBI-78260 MINT-8031294 MINT-8031309 MINT-8033265 MINT-8033250 I2D: score=3 
    SRCP129311, 2, 3EBI-716404,EBI-621482 MINT-8033220 MINT-8031279 I2D: score=4 
    XRCC6P129562, 3MINT-63486 I2D: score=4 
    JUPP149231, 3EBI-716404,EBI-702484 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006909phagocytosis IDA12110892
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS7994021
    GO:0007596blood coagulation TAS--

    PECAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PECAM1 (PECA1)

    Selected Novoseek inferred chemical compound relationships for PECAM1 gene (see all 60)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 70.3 78 16151023 (6), 17822316 (3), 15166262 (2), 11326478 (2) (see all 51)
    matrigel 58.4 7 19883577 (1), 9243511 (1), 10655298 (1), 12433657 (1) (see all 5)
    tyrosine 48.9 156 12972546 (6), 9774457 (5), 15201144 (4), 9054388 (4) (see all 48)
    laccer 35.2 11 16151023 (5), 15084746 (5)
    slex 31.2 1 18334960 (1)
    prasugrel 30.4 1 16754711 (1)
    adp 29.8 11 19850043 (2), 16754711 (1), 19096001 (1), 16546241 (1) (see all 6)
    paraffin 29.8 8 11844241 (2), 15355911 (2), 16096774 (1), 15679808 (1) (see all 5)
    carbimazole 26.6 5 10848805 (2), 10942385 (1)
    phosphotyrosine 26.5 9 7515918 (1), 1544907 (1), 9774457 (1), 9312087 (1)



    PECAM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PECAM1 gene: 
    NM_000442.4  

    Unigene Clusters for PECAM1:

    Platelet/endothelial cell adhesion molecule 1
    Hs.376675  [show with all ESTs], Hs.514412  [show with all ESTs]
    Unigene Representative Sequences: NM_000442, AF393678

    miRNA
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    hsa-miR-4291 hsa-miR-3614-3p hsa-miR-4272 hsa-miR-519a hsa-miR-3916 hsa-miR-3125 hsa-miR-1297 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidPECAM1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PECAM1 (NM_000442)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PECAM1
    Primer
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    OriGene qPCR primer pairs and template standards for PECAM1
    OriGene qSTAR qPCR primer pairs in human, mouse for PECAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PECAM1
      QuantiTect SYBR Green Assays in human, mouse, rat PECAM1
      QuantiFast Probe-based Assays in human, mouse, rat PECAM1

    Additional mRNA sequence: 

    AF281287.1 AF281288.1 AF281289.1 AF281290.1 AF281291.1 AF281292.1 AF281293.1 AF281294.1 
    AF281295.1 AF281296.1 AF281297.1 AF281298.1 AF281299.1 AF281300.1 AF281301.1 AF393676.1 
    AF393677.1 AF393678.1 JQ287500.1 S66450.1 X96849.1 

    19 DOTS entries:

    DT.40271821  DT.91998572  DT.100866813  DT.311597  DT.100016242  DT.100866816  DT.92000070  DT.100866810 
    DT.97759930  DT.100866803  DT.100866818  DT.40195550  DT.100866815  DT.120996412  DT.120996468  DT.92000018 
    DT.97763648  DT.100042610  DT.100866806 

    Selected AceView cDNA sequences (see all 439):

    AI686366 AL538940 AA056355 BM998585 BX358463 CR595917 BQ109454 CR621687 
    X96849 AL540335 BF435623 BM974903 CA440040 AI148494 BM699304 BU679657 
    CA434579 AW276352 BX098567 BQ880188 CA442225 AA713790 AI076568 C18167 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PECAM1 expression in normal human tissues (normalized intensities)      PECAM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATGAAACC
    PECAM1 Expression
    About this image


    PECAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 54 entries
             Mature Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
             Brain microvascular endothelial cells
             Human Aortic Endothelial Cells (HAEC)   
     
     Heart (Cardiovascular System)    fully expand to see all 22 entries
             Cushion Mesenchymal Cells Endocardium
             Atrioventricular Endocardial Cushion
             Cardiac progenitor cells
             Cardiomyocyte-like cells
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Endothelial Cells Blood Brain Barrier
             Brain microvascular endothelial cells
             Human Brain Microvascular Endothelial Cells (HBMEC)   
     
     Blood (Cardiovascular System)    fully expand to see all 9 entries
             Mesenchymal Stem Cells Cord Blood
             Angiogenic cell precursor
             Hematopoietic progenitor cells
     
     NULL (Uncategorized)    fully expand to see all 17 entries
             Stromal vascular fraction cells
             Blast colony cells
             Human Choroid Plexus Endothelial Cells (HCPEC)   
    PECAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PECAM1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.376675 Hs.514412

    UniProtKB/Swiss-Prot: PECA1_HUMAN, P16284
    Tissue specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between
    endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in
    trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with
    the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of
    platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL)
    and U-937 histiocytic lymphoma cell lines (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PECAM1 (see all 8): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Tight Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PECAM1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pecam11 , 5 platelet/endothelial cell adhesion molecule 11, 5 73.48(n)1
    64.32(a)1
      11 (69.92 cM)5
    186131  NM_008816.21  NP_032842.21 
     1066542175 
    chicken
    (Gallus gallus)
    Aves PECAM11 platelet/endothelial cell adhesion molecule 1 51.12(n)
    35.66(a)
      771243  XM_004946192.1  XP_004946249.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004936861 platelet endothelial cell adhesion molecule-like 45.85(n)
    33.89(a)
      100493686  XM_002942396.2  XP_002942442.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-237i9.81 si:dkey-237i9.8 44.44(n)
    30.45(a)
      100333180  XM_005166201.1  XP_005166258.1 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PECAM1 (see all 174)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997518561,2
    C--62396309(+) TACTC-/TTTTTTTT 1 -- cds10--------
    rs1168156741,2
    C,F--62396632(+) CCCCAC/TGCCTT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs129416981,2
    C,F,A,H--62396746(+) gtggtC/Tttaag 1 -- ds500112Minor allele frequency- T:0.46NS EA NA CSA WA 778
    rs1117180561,2
    C--62397176(+) TTATCG/AGGAAG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs776488471,2
    C--62397430(+) ATAGCA/CTGCTG 1 -- ut310--------
    rs780220471,2
    C,F--62397786(+) CAGGGC/ACTTCC 1 -- ut311Minor allele frequency- A:0.11WA 118
    rs2004114201,2
    C--62398069(+) AATCTC/TCCCAC 1 -- ut310--------
    rs1439459061,2
    C--62398216(+) TTGGTC/TGTGGG 1 -- ut310--------
    rs2008372131,2
    --62398351(+) GAGAC-/AAAATCGC 1 -- cds10--------
    rs72146431,2
    C,F,H--62398530(+) AAGTTC/G/TTACTG 2 -- ut3126NS EA NA WA CSA 2384

    HapMap Linkage Disequilibrium report for PECAM1 (62396775 - 62404856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PECAM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524852CNV Gain19592680

    Human Gene Mutation Database (HGMD): PECAM1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PECAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for PECAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173445    OMIM disorders: --

    Selected diseases for PECAM1 (see all 142):    About MalaCards
    angiosarcoma    erythema elevatum diutinum    epithelioid hemangioendothelioma    discoid lupus erythematosus
    angiosarcoma of the scalp    pyogenic granuloma    pulmonary vein stenosis    gastric lymphoma
    coronary stenosis    anal canal carcinoma    hemangioendothelioma    membranous glomerulonephritis
    arteriovenous malformation    thrombasthenia    brain glioma    glanzmann's thrombasthenia
    diffuse astrocytoma    hemoglobinopathy    cavernous hemangioma    epithelioid sarcoma


    PECAM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for PECAM1 gene (see all 80)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    angiosarcoma 52.6 3 18084256 (1)
    neovascularization 52.4 5 15818089 (2), 17654489 (1), 14517436 (1), 19515525 (1)
    melanoma experimental 47.9 1 7507944 (1)
    tumors 44.7 113 8226797 (9), 14517436 (4), 8604238 (3), 20074345 (3) (see all 65)
    inflammation 43.3 23 10900350 (2), 15589815 (2), 15756041 (1), 9159026 (1) (see all 17)
    hemangioma 40.6 6 9243511 (1), 9446823 (1), 18084256 (1)
    necrosis 38.9 17 8764109 (2), 17607964 (2), 17606807 (1), 9159026 (1) (see all 13)
    idiopathic membranous nephropathy 38.5 1 9551397 (1)
    atherosclerosis 34.2 15 15756041 (2), 17673705 (1), 19183069 (1), 14527361 (1) (see all 11)
    cerebral cavernous malformations 30.4 1 11844241 (1)

    Genetic Association Database (GAD): PECAM1
    Human Genome Epidemiology (HuGE) Navigator: PECAM1 (56 documents)

    Export disorders for PECAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PECAM1 gene, integrated from 10 sources (see all 832):
    (articles sorted by number of sources associating them with PECAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Codon 125 polymorphism of CD31 and susceptibility to malaria. (PubMed id 11791967)1, 2, 4 Casals-Pascual C....Roberts D.J. (Am. J. Trop. Med. Hyg. 2001)
    2. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. (PubMed id 1690453)1, 2, 3 Newman P.J.... Muller W.A. (Science 1990)
    3. Regulation of G protein-coupled receptor activities by the platelet- endothelial cell adhesion molecule, PECAM-1. (PubMed id 18672896)1, 2, 9 Yeh J.C.... Frangos J.A. (Biochemistry 2008)
    4. Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene &amp; soluble level of PECAM-1 with coronary artery disease in Asian Indians. (PubMed id 15756041)1, 4, 9 Fang L....Chatterjee S. (Indian J. Med. Res. 2005)
    5. Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium. (PubMed id 8226797)1, 2, 9 Tang D.G....Honn K.V. (J. Biol. Chem. 1993)
    6. Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms. (PubMed id 12433657)1, 2, 9 Wang Y.... Sheibani N. (Am. J. Physiol. 2003)
    7. Donor CD31 genotype impacts on transplant complications after human leukocyte antigen-matched sibling allogeneic bone marrow transplantation. (PubMed id 15753851)1, 4, 9 Cavanagh G....Middleton P.G. (Transplantation 2005)
    8. [Study of association of platelet endothelial cell adhesion molecule-1 gene polymorphism with acute myocardial infarction]. (PubMed id 19570335)1, 4, 9 Fu X.L....Xia Z.H. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009)
    9. Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with ischemic stroke. (PubMed id 19183069)1, 4, 9 Wei Y.S....Xie H.Y. (DNA Cell Biol. 2009)
    10. ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. (PubMed id 19306055)1, 4, 9 Burim R.V....Carlotti-JA_nior C.G. (Clin. Exp. Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5175 HGNC: 8823 AceView: PECAM1 euGenes: HUgn5175 ECgene: PECAM1 Kegg: 5175
    H-InvDB: PECAM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PECAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PECAM1 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PECAM-1
    Wikipedia http://en.wikipedia.org/wiki/CD31
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_265

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PECAM1 gene:
    Search GeneIP for patents involving PECAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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