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Aliases for PEBP4 Gene

Aliases for PEBP4 Gene

  • Phosphatidylethanolamine Binding Protein 4 2 3 5
  • Cousin-Of-RKIP 1 Protein 2 3
  • Protein Cousin-Of-RKIP 1 3 4
  • PEBP-4 3 4
  • HPEBP4 3 4
  • CORK1 3 4
  • Epididymis Secretory Protein Li 300 3
  • HEL-S-300 3
  • GWTM1933 3
  • PRO4408 3
  • CORK-1 3

External Ids for PEBP4 Gene

Previous GeneCards Identifiers for PEBP4 Gene

  • GC08M022626
  • GC08M022570
  • GC08M021113

Summaries for PEBP4 Gene

Entrez Gene Summary for PEBP4 Gene

  • The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]

GeneCards Summary for PEBP4 Gene

PEBP4 (Phosphatidylethanolamine Binding Protein 4) is a Protein Coding gene. An important paralog of this gene is PEBP1.

UniProtKB/Swiss-Prot for PEBP4 Gene

  • Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEBP4 Gene

Genomics for PEBP4 Gene

Regulatory Elements for PEBP4 Gene

Promoters for PEBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PEBP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PEBP4 Gene

Chromosome:
8
Start:
22,713,251 bp from pter
End:
23,000,000 bp from pter
Size:
286,750 bases
Orientation:
Minus strand

Genomic View for PEBP4 Gene

Genes around PEBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEBP4 Gene

Proteins for PEBP4 Gene

  • Protein details for PEBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S96-PEBP4_HUMAN
    Recommended name:
    Phosphatidylethanolamine-binding protein 4
    Protein Accession:
    Q96S96
    Secondary Accessions:
    • Q5EVA1
    • Q8WW74

    Protein attributes for PEBP4 Gene

    Size:
    227 amino acids
    Molecular mass:
    25733 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20779.1; Type=Frameshift; Positions=219; Evidence={ECO:0000305}; Sequence=AAQ89467.1; Type=Frameshift; Positions=219; Evidence={ECO:0000305};

neXtProt entry for PEBP4 Gene

Proteomics data for PEBP4 Gene at MOPED

Post-translational modifications for PEBP4 Gene

No Post-translational modifications

Other Protein References for PEBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PEBP4

No data available for DME Specific Peptides for PEBP4 Gene

Domains & Families for PEBP4 Gene

Protein Domains for PEBP4 Gene

Suggested Antigen Peptide Sequences for PEBP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S96

UniProtKB/Swiss-Prot:

PEBP4_HUMAN :
  • Belongs to the phosphatidylethanolamine-binding protein family.
Family:
  • Belongs to the phosphatidylethanolamine-binding protein family.
genes like me logo Genes that share domains with PEBP4: view

No data available for Gene Families for PEBP4 Gene

Function for PEBP4 Gene

Molecular function for PEBP4 Gene

UniProtKB/Swiss-Prot Function:
Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.
genes like me logo Genes that share phenotypes with PEBP4: view

Animal Model Products

CRISPR Products

miRNA for PEBP4 Gene

miRTarBase miRNAs that target PEBP4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEBP4 Gene

Localization for PEBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEBP4 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEBP4 Gene COMPARTMENTS Subcellular localization image for PEBP4 gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PEBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PEBP4: view

Pathways & Interactions for PEBP4 Gene

SuperPathways for PEBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PEBP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PEBP4 Gene

Drugs & Compounds for PEBP4 Gene

(1) Drugs for PEBP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for PEBP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
genes like me logo Genes that share compounds with PEBP4: view

Transcripts for PEBP4 Gene

Unigene Clusters for PEBP4 Gene

Phosphatidylethanolamine-binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEBP4 Gene

No ASD Table

Relevant External Links for PEBP4 Gene

GeneLoc Exon Structure for
PEBP4
ECgene alternative splicing isoforms for
PEBP4

Expression for PEBP4 Gene

mRNA expression in normal human tissues for PEBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEBP4 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.8), Muscle - Skeletal (x11.7), Heart - Atrial Appendage (x8.9), and Lung (x4.5).

Protein differential expression in normal tissues from HIPED for PEBP4 Gene

This gene is overexpressed in Serum (28.4), Vitreous humor (17.2), and Cerebrospinal fluid (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PEBP4 Gene



SOURCE GeneReport for Unigene cluster for PEBP4 Gene Hs.491242

mRNA Expression by UniProt/SwissProt for PEBP4 Gene

Q96S96-PEBP4_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in tumor cells.
genes like me logo Genes that share expression patterns with PEBP4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PEBP4 Gene

Orthologs for PEBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PEBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEBP4 35
  • 98.04 (n)
  • 97.29 (a)
PEBP4 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEBP4 36
  • 69 (a)
OneToOne
PEBP4 35
  • 80.06 (n)
  • 72.15 (a)
dog
(Canis familiaris)
Mammalia PEBP4 35
  • 81.28 (n)
  • 76.71 (a)
PEBP4 36
  • 44 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pebp4 16
Pebp4 35
  • 65.98 (n)
  • 56.41 (a)
Pebp4 36
  • 43 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PEBP4 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 11 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pebp4 35
  • 66.67 (n)
  • 53.09 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pebp4 35
  • 52.16 (n)
  • 43.53 (a)
zebrafish
(Danio rerio)
Actinopterygii PEBP4 36
  • 47 (a)
OneToOne
LOC101882266 35
  • 53.23 (n)
  • 51.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30060 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y69E1A.5 36
  • 24 (a)
OneToOne
Species with no ortholog for PEBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PEBP4 Gene

ENSEMBL:
Gene Tree for PEBP4 (if available)
TreeFam:
Gene Tree for PEBP4 (if available)

Paralogs for PEBP4 Gene

Paralogs for PEBP4 Gene

genes like me logo Genes that share paralogs with PEBP4: view

Variants for PEBP4 Gene

Sequence variations from dbSNP and Humsavar for PEBP4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1129474 - 22,727,205(-) TGAAG(A/G)AAGGG reference, missense
rs1047406 - 22,713,422(-) CAGAG(A/G)AAGGG reference, missense
rs876888 -- 22,776,777(-) GATCA(C/G)AAAAA intron-variant
rs937970 -- 22,912,626(+) CCATC(G/T)CCCCA intron-variant
rs937971 -- 22,863,720(+) GGTCT(C/T)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PEBP4 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv831267 CNV Gain 17160897
esv2027896 CNV Deletion 18987734
nsv396765 CNV Insertion 16902084
esv988282 CNV Insertion 20482838
nsv523385 CNV Loss 19592680
nsv517319 CNV Loss 19592680

Variation tolerance for PEBP4 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.70; 95.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PEBP4 Gene

HapMap Linkage Disequilibrium report
PEBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEBP4 Gene

Disorders for PEBP4 Gene

Relevant External Links for PEBP4

Genetic Association Database (GAD)
PEBP4
Human Genome Epidemiology (HuGE) Navigator
PEBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PEBP4

No disorders were found for PEBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PEBP4 Gene

Publications for PEBP4 Gene

  1. A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen- activated protein kinase pathway activation and phosphatidylethanolamine externalization. (PMID: 15302887) Wang X. … Cao X. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. (PMID: 16865237) Li P. … Cao X. (Int. J. Mol. Med. 2006) 2 3 23
  3. Regulation of human myoblast differentiation by PEBP4. (PMID: 19197339) Garcia R. … Kolch W. (EMBO Rep. 2009) 3 23
  4. Downregulation of PEBP4, a target of miR-34a, sensitizes drug-resistant lung cancer cells. (PMID: 25038915) Yu G. … Wu S. (Tumour Biol. 2014) 3
  5. A genome-wide association meta-analysis of preschool internalizing problems. (PMID: 24839885) Benke K.S. … Middeldorp C.M. (J Am Acad Child Adolesc Psychiatry 2014) 3

Products for PEBP4 Gene

Sources for PEBP4 Gene

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