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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PEBP1 Gene

protein-coding   GIFtS: 60
GCID: GC12P118573

Phosphatidylethanolamine Binding Protein 1

(Previous name: prostatic binding protein)
(Previous symbol: PBP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylethanolamine Binding Protein 11 2     Prostatic-Binding Protein2 3
PBP1 2 3 5     Raf Kinase Inhibitor Protein2 3
RKIP2 3 5     HCNPpp2 3
Prostatic Binding Protein1 2     PEBP2 3
Hippocampal Cholinergic Neurostimulating Peptide1 2     PEBP-12 3
Raf Kinase Inhibitory Protein1 2     HCNP2
Neuropolypeptide H32 3     Phosphatidylethanolamine-Binding Protein 12

External Ids:    HGNC: 86301   Entrez Gene: 50372   Ensembl: ENSG000000892207   OMIM: 6045915   UniProtKB: P300863   

Export aliases for PEBP1 gene to outside databases

Previous GC identifers: GC12P117058 GC12P115583


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PEBP1 Gene: 
PEBP1 (phosphatidylethanolamine binding protein 1) is a protein-coding gene. Diseases associated with PEBP1 include acute liver failure, and merkel cell carcinoma. GO annotations related to this gene include phosphatidylethanolamine binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is PEBP4.

UniProtKB/Swiss-Prot: PEBP1_HUMAN, P30086
Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and
phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not
trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by
inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK
phosphorylation
Function: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous
system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be
mediated by a specific receptor (By similarity)

Gene Wiki entry for PEBP1 (Phosphatidylethanolamine binding protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PEBP1 gene promoter:
         c-Fos   PPAR-gamma1   AP-1   ATF-2   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPEBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PEBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24

PEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEBP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P118573:  view genomic region     (about GC identifiers)

Start:
118,573,663 bp from pter      End:
118,583,390 bp from pter
Size:
9,728 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PEBP1_HUMAN, P30086 (See protein sequence)
Recommended Name: Phosphatidylethanolamine-binding protein 1  
Size: 187 amino acids; 21057 Da
Subunit: Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this
interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'
Subcellular location: Cytoplasm (By similarity)
4 PDB 3D structures from and Proteopedia for PEBP1:
1BD9 (3D)        1BEH (3D)        2L7W (3D)        2QYQ (3D)    
Secondary accessions: B2R4S1

Explore the universe of human proteins at neXtProt for PEBP1: NX_P30086

Explore proteomics data for PEBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30086

  • PEBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PEBP1 Protein Expression
    REFSEQ proteins: NP_002558.1  
    ENSEMBL proteins: 
     ENSP00000261313  

    Human Recombinant Protein Products for PEBP1: 
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    Novus Biologicals PEBP1 Proteins
    Novus Biologicals PEBP1 Lysate
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for PEBP1
    Cloud-Clone Corp. Proteins for PEBP1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PEBP1 for ontologies           About GeneDecksing



    PEBP1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for PEBP1 

    Assay Products for PEBP1: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PEBP1 
    Cloud-Clone Corp. CLIAs for PEBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR008914 PtdEtn-bd_prot_PEBP
     IPR001858 Phosphotidylethanolamine-bd_CS

    Graphical View of Domain Structure for InterPro Entry P30086

    ProtoNet protein and cluster: P30086

    1 Blocks protein domain: IPB001858 Phosphatidylethanolamine-binding protein

    UniProtKB/Swiss-Prot: PEBP1_HUMAN, P30086
    Similarity: Belongs to the phosphatidylethanolamine-binding protein family


    PEBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEBP1_HUMAN, P30086
    Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and
    phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not
    trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by
    inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK
    phosphorylation
    Function: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous
    system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be
    mediated by a specific receptor (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding IPI17097642
    GO:0005524ATP binding IEA--
    GO:0008429phosphatidylethanolamine binding TAS7637590
    GO:0019899enzyme binding IPI--
         
    PEBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pebp1):
     taste/olfaction 

    PEBP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PEBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PEBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PEBP1 
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    hsa-miR-607 hsa-miR-224 hsa-miR-4272 hsa-miR-624*
    SwitchGear 3'UTR luciferase reporter plasmidPEBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEBP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PEBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAP Kinase Signaling
    MAP Kinase Signaling
    2ErbB1 downstream signaling
    ErbB1 downstream signaling
    3EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    4Aurora B signaling
    Aurora B signaling
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PEBP1
        MAP Kinase Signaling

    4 BioSystems Pathways for PEBP1
        EGFR1 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    ErbB1 downstream signaling
    Aurora B signaling




    PEBP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PEBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for PEBP1 (P300862, 3 ENSP000002613134) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STC2O760612, 3, ENSP000002650874MINT-63641 I2D: score=5 STRING: ENSP00000265087
    PIK3R1P279862, 3, ENSP000002743354MINT-8112147 I2D: score=3 STRING: ENSP00000274335
    MED10Q9BTT42, 3MINT-65335 I2D: score=4 
    TRAF6Q9Y4K32, 3MINT-7386121 I2D: score=2 
    RAF1P040492, 3, ENSP000002518494MINT-3389495 MINT-3389468 MINT-3389522 MINT-3389581 MINT-3389607 MINT-3389550 MINT-3389378 I2D: score=6 STRING: ENSP00000251849
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PEBP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PEBP1

    10/2150 HMDB Compounds for PEBP1 (see all 2150)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----
    PC(14:0/16:0)GPCho(30:0) (see all 8)----
    PC(14:0/16:1(9Z))1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:0)1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (see all 8)----

    10/12 Novoseek inferred chemical compound relationships for PEBP1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylethanolamine 69 61 17143548 (3), 19564817 (3), 8738137 (2), 12193403 (2) (see all 15)
    glyceraldehyde 3-phosphate 58 6 18161940 (1), 10612659 (1), 16440601 (1), 16431015 (1) (see all 6)
    manganese superoxide 40.1 1 16876904 (1)
    flutamide 31.9 4 8252497 (1)
    malate 18.2 2 17569552 (1), 16431015 (1)
    acetylcholine 16 16 19815004 (3), 7637590 (1), 8888012 (1), 16361812 (1) (see all 5)
    serine 8.87 4 15713484 (1), 17018026 (1)
    phospholipid 2.1 4 20463977 (2), 9651495 (1)
    superoxide 0.619 2 17569552 (1), 16431015 (1)
    calcium 0 1 15155742 (1)

    Search CenterWatch for drugs/clinical trials and news about PEBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PEBP1 gene: 
    NM_002567.2  

    Unigene Cluster for PEBP1:

    Phosphatidylethanolamine binding protein 1
    Hs.433863  [show with all ESTs]
    Unigene Representative Sequence: BM921938
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261313(uc010szc.1 uc001twu.1) ENST00000542939

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK226006.1 AK299414.1 AK308056.1 AK311927.1 BC008714.2 BC017396.1 BC018799.1 BC031102.1 
    D16111.1 HM131449.1 S76773.1 X75252.1 X85033.1 

    24/43 DOTS entries (see all 43):

    DT.100690731  DT.454472  DT.92001296  DT.100690739  DT.100690734  DT.100690746  DT.91767947  DT.97820294 
    DT.100875001  DT.97793239  DT.92007453  DT.92008246  DT.121120956  DT.100690728  DT.100690747  DT.121120993 
    DT.95229437  DT.100690733  DT.91767953  DT.100690741  DT.121121014  DT.95229502  DT.100690735  DT.100690738 

    24/1673 AceView cDNA sequences (see all 1673):

    BU737254 BQ072218 F28606 BE880533 BM699516 BM697195 BX463478 BP369264 
    CF139688 AW337554 BQ681956 BG655476 BP349634 AA812078 BQ423981 AA279935 
    BU177802 CA488158 BX421025 BX423325 BQ632063 CD514922 CR612913 CR626465 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PEBP1 expression in normal human tissues (normalized intensities)      PEBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTAAGAA
    PEBP1 Expression
    About this image


    PEBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 6 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal gland ; glandular cells   
             Adrenal Cortex   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             liver ; bile duct cells   

    See PEBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PEBP1

    SOURCE GeneReport for Unigene cluster: Hs.433863
        SABiosciences Custom PCR Arrays for PEBP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PEBP1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pebp11 , 5 phosphatidylethanolamine binding protein 11, 5 86.1(n)1
    86.1(a)1
      5 (56.88 cM)5
    239801  NM_018858.21  NP_061346.21 
     1172826515 
    chicken
    (Gallus gallus)
    Aves PEBP11 phosphatidylethanolamine binding protein 1 75.76(n)
    80.21(a)
      416990  NM_001198642.1  NP_001185571.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    74(a)
    58(a)
    1 ↔ many
    1 ↔ many
    LGb(2751633-2758360)
    GL343338.1(716818-725330)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560332 similar to phosphatidylethanolamine binding protein 74.94(n)   393958  BC047812.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102981 CG10298 59.8(n)
    58.18(a)
      40779  NM_141386.2  NP_649643.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F40A3.36
    Phosphatidylethanolamine-binding protein homolog F...
    42(a)
    1 ↔ 1
    V(7877500-7878501)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons E12A111 protein MOTHER of FT and TF 1 47.88(n)
    36.51(a)
      838390  NM_101672.3  NP_173250.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g04988001 hypothetical protein 52.38(n)
    40.95(a)
      4341107  NM_001064236.1  NP_001057701.1 


    ENSEMBL Gene Tree for PEBP1 (if available)
    TreeFam Gene Tree for PEBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PEBP1 gene
    PEBP42  
    1 SIMAP similar gene for PEBP1 using alignment to 1 protein entry:     PEBP1_HUMAN:
    MRPL38

    PEBP1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for PEBP1
    PGOHUM00000247888 PGOHUM00000244386 PGOHUM00000240123 PGOHUM00000260639


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/251 SNPs in PEBP1 are shown (see all 251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0060484
    ----see VAR_0060482 S N mis40--------
    rs1899401371,2
    --118364896(+) ACTACC/TGGCAC 1 -- us2k10--------
    rs1168986761,2
    C,F--118364901(+) CGGCAC/TATCCC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1826691161,2
    --118571947(+) GCAACC/TGCACC 1 -- us2k10--------
    rs619435211,2
    C,F--118571961(+) CCTGAC/TGACCT 1 -- us2k16Minor allele frequency- T:0.20NA CSA WA EA 363
    rs1878436631,2
    --118572071(+) GATATA/GCCCTA 1 -- us2k10--------
    rs1924452951,2
    --118572088(+) TACTGA/GCGTTT 1 -- us2k10--------
    rs1840035641,2
    --118572250(+) AACAGA/GTAAGA 1 -- us2k10--------
    rs1400961121,2
    --118572278(+) ATTGGC/GTGGGC 1 -- us2k10--------
    rs764593181,2
    C,F--118572285(+) GGGCGC/TGGTGG 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for PEBP1 (118573663 - 118583390 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PEBP1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PEBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PEBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604591    OMIM disorders: --

    20/38 diseases for PEBP1 (see all 38):    About MalaCards
    acute liver failure    merkel cell carcinoma    prostatitis    endocarditis
    pancreatic ductal adenocarcinoma    gastric adenocarcinoma    epididymitis    celiac disease
    nasopharyngitis    thyroid cancer    alzheimer's disease    down syndrome
    acute myeloid leukemia    prostate cancer    esophageal cancer    astrocytoma
    thyroiditis    adenocarcinoma    cervical cancer    pancreatitis


    PEBP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for PEBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 40.3 32 16243812 (4), 15565643 (3), 15289323 (2), 16757329 (2) (see all 14)
    alzheimers disease 33.6 10 19101508 (2), 11853019 (2), 18781826 (1), 19803424 (1) (see all 5)
    prostate cancer 32.3 13 15565643 (3), 16175585 (2), 19779262 (2), 15151133 (1) (see all 7)
    primary tumor 21.2 1 15565643 (1)
    melanoma 20.8 13 15289323 (7), 18567796 (1), 18323787 (1)
    tumors 15.7 22 17911631 (4), 16243812 (3), 17201166 (2), 19803424 (2) (see all 10)
    cancer 11.2 12 15327891 (3), 18161940 (1), 19291429 (1), 17094902 (1) (see all 9)
    necrosis 0 2 15949695 (1)
    shock 0 4 15712240 (1), 16557598 (1), 18325775 (1)
    nsclc 0 1 17094902 (1)

    Genetic Association Database (GAD): PEBP1

    Export disorders for PEBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PEBP1 gene, integrated from 9 sources (see all 229):
    (articles sorted by number of sources associating them with PEBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. (PubMed id 7637590)1, 2, 9 Tohdoh N.... Ojika K. (1995)
    2. Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. (PubMed id 9782050)1, 2, 9 Banfield M.J.... Brady R.L. (1998)
    3. Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. (PubMed id 7807553)1, 2, 9 Seddiqi N.... Schoentgen F. (1994)
    4. A human cDNA sequence homologue of bovine phosphatidylethanolamine- binding protein. (PubMed id 8144042)1, 2, 9 Hori N....Matsubara K. (1994)
    5. The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. (PubMed id 18294816)1, 2 Rath O....Yeung K.C. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. RKIP downregulates B-Raf kinase activity in melanoma cancer cells. (PubMed id 15782137)1, 3 Park S....Yeung K.C. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Hippocampal cholinergic neurostimulating peptides (HCNP). (PubMed id 10622376)1, 2 Ojika K....Matsukawa N. (2000)
    10. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. (PubMed id 10490027)1, 2 Yeung K.... Kolch W. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5037 HGNC: 8630 AceView: PBP Ensembl:ENSG00000089220 euGenes: HUgn5037
    ECgene: PEBP1 H-InvDB: PEBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PEBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PEBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PEBP1 gene:
    Search GeneIP for patents involving PEBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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