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Aliases for PEBP1 Gene

Aliases for PEBP1 Gene

  • Phosphatidylethanolamine Binding Protein 1 2 3 5
  • Hippocampal Cholinergic Neurostimulating Peptide 2 3
  • Raf Kinase Inhibitory Protein 2 3
  • Raf Kinase Inhibitor Protein 3 4
  • Prostatic Binding Protein 2 3
  • Neuropolypeptide H3 3 4
  • HCNPpp 3 4
  • PEBP-1 3 4
  • PEBP 3 4
  • RKIP 3 4
  • PBP 3 4
  • Epididymis Secretory Protein Li 34 3
  • Epididymis Secretory Protein Li 96 3
  • Epididymis Luminal Protein 210 3
  • Prostatic-Binding Protein 4
  • HEL-S-34 3
  • HEL-S-96 3
  • HEL-210 3
  • HCNP 3

External Ids for PEBP1 Gene

Previous HGNC Symbols for PEBP1 Gene

  • PBP

Previous GeneCards Identifiers for PEBP1 Gene

  • GC12P117058
  • GC12P118573
  • GC12P115583

Summaries for PEBP1 Gene

Entrez Gene Summary for PEBP1 Gene

  • This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

GeneCards Summary for PEBP1 Gene

PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Diseases associated with PEBP1 include Gastric Cardia Adenocarcinoma. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is PEBP4.

UniProtKB/Swiss-Prot for PEBP1 Gene

  • Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.

  • HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Gene Wiki entry for PEBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEBP1 Gene

Genomics for PEBP1 Gene

Regulatory Elements for PEBP1 Gene

Enhancers for PEBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PEBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PEBP1 Gene

Chromosome:
12
Start:
118,135,858 bp from pter
End:
118,145,585 bp from pter
Size:
9,728 bases
Orientation:
Plus strand

Genomic View for PEBP1 Gene

Genes around PEBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEBP1 Gene

Proteins for PEBP1 Gene

  • Protein details for PEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30086-PEBP1_HUMAN
    Recommended name:
    Phosphatidylethanolamine-binding protein 1
    Protein Accession:
    P30086
    Secondary Accessions:
    • B2R4S1

    Protein attributes for PEBP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21057 Da
    Quaternary structure:
    • Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues Ser-338, Ser-339, Tyr-340 and Tyr-341. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for PEBP1 Gene

neXtProt entry for PEBP1 Gene

Proteomics data for PEBP1 Gene at MOPED

Post-translational modifications for PEBP1 Gene

  • Ubiquitination at Lys 7, Lys 47, Lys 113, and Lys 132
  • Modification sites at PhosphoSitePlus

Other Protein References for PEBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PEBP1 (RKIP)

No data available for DME Specific Peptides for PEBP1 Gene

Domains & Families for PEBP1 Gene

Protein Domains for PEBP1 Gene

Suggested Antigen Peptide Sequences for PEBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P30086

UniProtKB/Swiss-Prot:

PEBP1_HUMAN :
  • Belongs to the phosphatidylethanolamine-binding protein family.
Family:
  • Belongs to the phosphatidylethanolamine-binding protein family.
genes like me logo Genes that share domains with PEBP1: view

No data available for Gene Families for PEBP1 Gene

Function for PEBP1 Gene

Molecular function for PEBP1 Gene

UniProtKB/Swiss-Prot Function:
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
UniProtKB/Swiss-Prot Function:
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
genes like me logo Genes that share phenotypes with PEBP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PEBP1 Gene

Localization for PEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEBP1 Gene COMPARTMENTS Subcellular localization image for PEBP1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PEBP1 Gene

Pathways & Interactions for PEBP1 Gene

SuperPathways for PEBP1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by GPCR
5 MAP Kinase Signaling
genes like me logo Genes that share pathways with PEBP1: view

Pathways by source for PEBP1 Gene

1 Cell Signaling Technology pathway for PEBP1 Gene

SIGNOR curated interactions for PEBP1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with PEBP1: view

Drugs & Compounds for PEBP1 Gene

(7) Drugs for PEBP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for PEBP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
genes like me logo Genes that share compounds with PEBP1: view

Transcripts for PEBP1 Gene

mRNA/cDNA for PEBP1 Gene

Unigene Clusters for PEBP1 Gene

Phosphatidylethanolamine binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEBP1 Gene

No ASD Table

Relevant External Links for PEBP1 Gene

GeneLoc Exon Structure for
PEBP1
ECgene alternative splicing isoforms for
PEBP1

Expression for PEBP1 Gene

mRNA expression in normal human tissues for PEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEBP1 Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for PEBP1 Gene

This gene is overexpressed in Liver, secretome (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEBP1 Gene



SOURCE GeneReport for Unigene cluster for PEBP1 Gene Hs.433863

genes like me logo Genes that share expression patterns with PEBP1: view

Protein tissue co-expression partners for PEBP1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PEBP1 Gene

Orthologs for PEBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PEBP1 35
  • 89.84 (n)
  • 93.58 (a)
PEBP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PEBP1 35
  • 89.13 (n)
  • 91.98 (a)
PEBP1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pebp1 35
  • 86.1 (n)
  • 86.1 (a)
Pebp1 16
Pbp2 36
  • 84 (a)
OneToMany
Pebp1 36
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PEBP1 35
  • 99.47 (n)
  • 100 (a)
PEBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pebp1 35
  • 83.42 (n)
  • 83.42 (a)
oppossum
(Monodelphis domestica)
Mammalia PEBP1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PEBP1 35
  • 75.76 (n)
  • 80.21 (a)
PEBP1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PEBP1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pebp1 35
  • 71.53 (n)
  • 76.76 (a)
zebrafish
(Danio rerio)
Actinopterygii pebp1 35
  • 68.98 (n)
  • 71.66 (a)
zgc56033 35
pebp1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012962 35
  • 58.49 (n)
  • 55.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10298 35
  • 59.8 (n)
  • 58.18 (a)
CG10298 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F40A3.3 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7271 36
  • 48 (a)
OneToOne
Species with no ortholog for PEBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PEBP1 Gene

ENSEMBL:
Gene Tree for PEBP1 (if available)
TreeFam:
Gene Tree for PEBP1 (if available)

Paralogs for PEBP1 Gene

Paralogs for PEBP1 Gene

(2) SIMAP similar genes for PEBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PEBP1 Gene

genes like me logo Genes that share paralogs with PEBP1: view

Variants for PEBP1 Gene

Sequence variations from dbSNP and Humsavar for PEBP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_006048 -
rs2020087 -- 118,141,712(+) ctggg(C/T)gatag intron-variant
rs13893 -- 118,144,837(+) TGGAG(C/G)CCCCA utr-variant-3-prime
rs79705369 -- 118,141,987(+) AACTT(A/C)TGTGT intron-variant
rs34442636 -- 118,141,491(+) ATGTT(-/G)GGGAG intron-variant

Variation tolerance for PEBP1 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PEBP1 Gene

Human Gene Mutation Database (HGMD)
PEBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PEBP1 Gene

Disorders for PEBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PEBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
- elite association - COSMIC cancer census association via MalaCards
Search PEBP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PEBP1

Genetic Association Database (GAD)
PEBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PEBP1
genes like me logo Genes that share disorders with PEBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEBP1 Gene

Publications for PEBP1 Gene

  1. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. (PMID: 7637590) Tohdoh N. … Ojika K. (Brain Res. Mol. Brain Res. 1995) 3 4 23 67
  2. Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue. (PMID: 19291429) Wang J. … Wang D. (Med. Oncol. 2010) 3 23
  3. Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation. (PMID: 20028985) Takemura T. … Ohnishi K. (J. Biol. Chem. 2010) 3 23
  4. Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. (PMID: 20463977) Shemon A.N. … Koide S. (PLoS ONE 2010) 3 23
  5. Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease. (PMID: 19101508) Okita K. … Ojika K. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for PEBP1 Gene

Sources for PEBP1 Gene