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PEAR1 Gene

protein-coding   GIFtS: 50
GCID: GC01P156865

Platelet Endothelial Aggregation Receptor 1

(Previous name: multiple EGF-like-domains 12)
(Previous symbol: MEGF12)
  Search for PEAR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet Endothelial Aggregation Receptor 11 2     Multiple Epidermal Growth Factor-Like Domains Protein 122 3
MEGF121 2 3     hPEAR12 3
Multiple EGF-Like-Domains 121 2     JEDI2
Multiple EGF-Like Domains Protein 122 3     

External Ids:    HGNC: 336311   Entrez Gene: 3750332   Ensembl: ENSG000001878007   OMIM: 6102785   UniProtKB: Q5VY433   

Export aliases for PEAR1 gene to outside databases

Previous GC identifers: GC01P153666 GC01P155130 GC01P128221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PEAR1 Gene:
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet
activation and secondary to platelet aggregation (Nanda et al., 2005 (PubMed 15851471)).(supplied by OMIM, Mar
2008)

GeneCards Summary for PEAR1 Gene:
PEAR1 (platelet endothelial aggregation receptor 1) is a protein-coding gene. An important paralog of this gene is SCARF1.

UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
Function: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PEAR1 gene promoter:
         AML1a   GATA-3   p53   Olf-1   FOXD1   CUTL1   LCR-F1   NF-AT   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PEAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PEAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

PEAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEAR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156865:  view genomic region     (about GC identifiers)

Start:
156,863,490 bp from pter      End:
156,886,226 bp from pter
Size:
22,737 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43 (See protein sequence)
Recommended Name: Platelet endothelial aggregation receptor 1 precursor  
Size: 1037 amino acids; 110666 Da
Subunit: Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation
Sequence caution: Sequence=BAB84947.1; Type=Frameshift; Positions=557;
Secondary accessions: Q8TEK2

Explore the universe of human proteins at neXtProt for PEAR1: NX_Q5VY43

Explore proteomics data for PEAR1 at MOPED

Post-translational modifications: 

  • Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine
    residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and
    thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its
    association with SHC1 and SHC21
  • Glycosylation2 at Asn152, Asn271, Asn476, Asn575, Asn634
  • Modification sites at PhosphoSitePlus

  • See PEAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073940.1  
    ENSEMBL proteins: 
     ENSP00000397870   ENSP00000344465   ENSP00000389742   ENSP00000292357  

    PEAR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PEAR1

     
    Search eBioscience for Proteins for PEAR1 

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    LSBio Antibodies in human, mouse, rat for PEAR1

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    Search eBioscience for ELISAs for PEAR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR011489 EMI_domain
     IPR002049 EGF_laminin
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q5VY43

    ProtoNet protein and cluster: Q5VY43

    1 Blocks protein domain: IPB011489 EMI

    UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
    Similarity: Belongs to the MEGF family
    Similarity: Contains 9 EGF-like domains
    Similarity: Contains 1 EMI domain


    Find genes that share domains with PEAR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEAR1_HUMAN, Q5VY43
    Function: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PEAR1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PEAR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PEAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PEAR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PEAR1

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    Selected qRT-PCR Assays for microRNAs that regulate PEAR1 (see all 11):
    hsa-miR-485-5p hsa-miR-1206 hsa-miR-24-1* hsa-miR-4268 hsa-miR-1291 hsa-miR-24-2* hsa-miR-221* hsa-miR-370
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PEAR1_HUMAN, Q5VY43: Cell membrane; Single-pass membrane protein (Potential). Note=Detected on the cell surface
    in resting platelets
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891phagocytic cup IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PEAR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PEAR1
    Interactions:

        Search GeneGlobe Interaction Network for PEAR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PEAR1 (ENSP000002923574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP10ENSP000003165894STRING: ENSP00000316589
    SNRNP200ENSP000003171234STRING: ENSP00000317123
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043654recognition of apoptotic cell IEA--

    Find genes that share ontologies with PEAR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PEAR1

    3 PharmGKB related drug/compound annotations for PEAR1 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  
    clopidogrelCA  
    prasugrelCA  



    Find genes that share compounds with PEAR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PEAR1 gene (2 alternative transcripts): 
    NM_001080471.1  NM_207369.1  

    Unigene Cluster for PEAR1:

    Platelet endothelial aggregation receptor 1
    Hs.142003  [show with all ESTs]
    Unigene Representative Sequence: NM_001080471
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444016 ENST00000338302 ENST00000455314 ENST00000469390(uc001fqk.1)
    ENST00000482505 ENST00000465101 ENST00000292357(uc009wsl.1 uc001fqj.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat PEAR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PEAR1 (see all 11):
    hsa-miR-485-5p hsa-miR-1206 hsa-miR-24-1* hsa-miR-4268 hsa-miR-1291 hsa-miR-24-2* hsa-miR-221* hsa-miR-370
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEAR1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PEAR1
      QuantiFast Probe-based Assays in human, mouse, rat PEAR1

    Additional mRNA sequence: 

    AK074121.1 AK098809.1 

    4 DOTS entries:

    DT.100747264  DT.421851  DT.100747265  DT.92034522 

    Selected AceView cDNA sequences (see all 72):

    AL040177 AW594288 BE502716 AA132043 BU741416 AI697757 AA515689 AW237134 
    AK074121 BM989236 CR609390 BX090671 BG005293 AI123863 CR599082 AW302445 
    AI160078 CB409465 BU785495 AI625773 BM724776 BU191299 AI740582 AW029027 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PEAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCGCACCC
    PEAR1 Expression
    About this image

    PEAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PEAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142003

    UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
    Tissue specificity: Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in
    heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal
    root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle
    and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PEAR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pear11 , 5 platelet endothelial aggregation receptor 11, 5 83.28(n)1
    83.65(a)1
      3 (38.50 cM)5
    731821  NM_001032413.11  NP_001027585.11 
     877478905 
    chicken
    (Gallus gallus)
    Aves PEAR11 platelet endothelial aggregation receptor 1 65.47(n)
    58.62(a)
      100857779  XM_004948188.1  XP_004948245.1 
    lizard
    (Anolis carolinensis)
    Reptilia PEAR16
    platelet endothelial aggregation receptor 1
    56(a)
    1 ↔ 1
    GL343640.1(135964-174404)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pear11 platelet endothelial aggregation receptor 1 60.26(n)
    53.51(a)
      100489801  XM_002938990.2  XP_002939036.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pear11 platelet endothelial aggregation receptor 1 57.06(n)
    51.04(a)
      571812  XM_695441.5  XP_700533.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta drpr6
    draper
    32(a)
    1 → many
    3L(1715595-1731107)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-16
    Protein CED-1, isoform c
    29(a)
    1 → many
    I(11851343-11868105) WBGene00000415


    ENSEMBL Gene Tree for PEAR1 (if available)
    TreeFam Gene Tree for PEAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PEAR1 gene
    SCARF12  MEGF112  MEGF102  SCARF22  
    3 SIMAP similar genes for PEAR1 using alignment to 3 protein entries:     PEAR1_HUMAN (see all proteins):
    MEGF10    MEGF11    SCARF1

    Find genes that share paralogs with PEAR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PEAR1 (see all 755)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75481811,2
    C,F,H--156861531(+) tttatT/Cgtatg 1 -- us2k15Minor allele frequency- C:0.04NS EA WA 536
    rs1436383381,2
    --156861556(+) ATACAG/TTTGAG 1 -- us2k10--------
    rs29867161,2
    C,F,H--156861589(+) ATGATC/ACTGCT 1 -- us2k120Minor allele frequency- A:0.26NS EA NA WA CSA 1204
    rs753373131,2
    C,F--156861678(+) CAGACC/TTCGGT 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs1481199941,2
    --156861771(+) GAGCCC/TAGGAA 1 -- us2k10--------
    rs46610661,2
    C,A,H--156861808(+) gaaacA/Cccatc 1 -- us2k18Minor allele frequency- C:0.06NA WA CSA 16
    rs1822564751,2
    --156861839(+) TAGCCA/TGACGT 1 -- us2k10--------
    rs1456346271,2
    C--156861849(+) TGTGG-/GCGCGCG 1 -- us2k10--------
    rs115864611,2
    H--156861850(+) gtgggC/Ggcgcg 1 -- us2k10--------
    rs668633281,2
    C--156861855(+) CGCGC-/GCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PEAR1 (156863490 - 156886226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PEAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831659CNV Loss17160897
    nsv831648CNV Loss17160897

    Human Gene Mutation Database (HGMD): PEAR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PEAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for PEAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610278    OMIM disorders: --


    Find genes that share disorders with PEAR1           About GenesLikeMe

    Genetic Association Database (GAD): PEAR1
    Human Genome Epidemiology (HuGE) Navigator: PEAR1 (3 documents)

    Export disorders for PEAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PEAR1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PEAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. (PubMed id 15851471)1, 2, 3, 9 Nanda N.... Hart M.J. (J. Biol. Chem. 2005)
    2. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. (PubMed id 18511696)1, 4, 9 Herrera-Galeano J.E....Becker L.C. (Arterioscler. Thromb. Vasc. Biol. 2008)
    3. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PubMed id 20526338)1, 4 Johnson A.D....Becker L.C. (Nat. Genet. 2010)
    4. A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. (PubMed id 19429868)1, 4 Jones C.I....Ouwehand W.H. (Blood 2009)
    5. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. (PubMed id 23667054)1 Kauskot A....Hoylaerts M.F. (Blood 2013)
    6. Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics. (PubMed id 23859572)1 Xiang Q....Zhao N. (Pharmacogenomics 2013)
    7. Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation. (PubMed id 23704978)1 Kim Y....Mathias R.A. (PLoS ONE 2013)
    8. Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes. (PubMed id 23392654)1 Lewis J.P....Shuldiner A.R. (Circ Cardiovasc Genet 2013)
    9. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. (PubMed id 21791418)1 Faraday N....Becker L.C. (Blood 2011)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375033 HGNC: 33631 AceView: FLJ00193 Ensembl:ENSG00000187800 euGenes: HUgn375033
    ECgene: PEAR1 H-InvDB: PEAR1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PEAR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PEAR1 gene:
    Search GeneIP for patents involving PEAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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