Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PEAR1 Gene

protein-coding   GIFtS: 47
GCID: GC01P156865

platelet endothelial aggregation receptor 1

(Previous name: multiple EGF-like-domains 12 )
(Previous symbol: MEGF12)
 Explore 1 disease affiliated with
PEAR1 via our new
 Human Malady Compendium 
Biological research products
for PEAR1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Platelet Endothelial Aggregation Receptor 11 2     Multiple EGF-Like Domains Protein 122 3
MEGF121 2 3     Multiple Epidermal Growth Factor-Like Domains Protein 122 3
JEDI1 2     HPEAR11
Multiple EGF-Like-Domains 121 2     FLJ001931

External Ids:    HGNC: 336311   Entrez Gene: 3750332   Ensembl: ENSG000001878007   OMIM: 6102785   UniProtKB: Q5VY433   

Export aliases for PEAR1 gene to outside databases

Previous GC identifers: GC01P153666 GC01P155130 GC01P128221


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PEAR1:
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet
activation and secondary to platelet aggregation (Nanda et al., 2005 (PubMed 15851471)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
Function: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PEAR1 gene promoter:
         AML1a   GATA-3   p53   Olf-1   FOXD1   CUTL1   LCR-F1   NF-AT   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PEAR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

PEAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEAR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156865:  view genomic region     (about GC identifiers)

Start:
156,863,490 bp from pter      End:
156,886,226 bp from pter
Size:
22,737 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43 (See protein sequence)
Recommended Name: Platelet endothelial aggregation receptor 1 precursor  
Size: 1037 amino acids; 110666 Da
Subunit: Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation
Subcellular location: Cell membrane; Single-pass membrane protein (Potential). Note=Detected on the cell surface in
resting platelets
Sequence caution: Sequence=BAB84947.1; Type=Frameshift; Positions=557;
Secondary accessions: Q8TEK2

Explore the universe of human proteins at neXtProt for PEAR1: NX_Q5VY43

Post-translational modifications:

  • Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by
  • SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and
    platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with
    SHC1 and SHC21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5VY43

  • PEAR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001073940.1  
    ENSEMBL proteins: 
     ENSP00000397870   ENSP00000344465   ENSP00000389742   ENSP00000292357  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PEAR1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PEAR1 
    GenScript Custom Purified and Recombinant Proteins Services for PEAR1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PEAR1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891phagocytic cup IEA--
    GO:0016021integral to membrane IEA--


    PEAR1 for ontologies           About GeneDecksing



    PEAR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PEAR1
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PEAR1 
    GenScript Custom Superior Antibodies Services for PEAR1
    Novus Biologicals PEAR1 Antibody
    Search for Antibodies for PEAR1 at Abcam  
    Uscn Antibodies for PEAR1
    ThermoFisher Antibodies for PEAR1

    Assay Products for PEAR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PEAR1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PEAR1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PEAR1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000742 EG-like_dom
     IPR011489 EMI_domain
     IPR002049 EGF_laminin
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q5VY43

    ProtoNet protein and cluster: Q5VY43

    1 Blocks protein family: IPB011489 EMI

    UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
    Similarity: Belongs to the MEGF family
    Similarity: Contains 9 EGF-like domains
    Similarity: Contains 1 EMI domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
    Function: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By
    similarity)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PEAR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEAR1
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PEAR1 (see all 11):
    hsa-miR-485-5p hsa-miR-1206 hsa-miR-24-1* hsa-miR-4268 hsa-miR-1291 hsa-miR-24-2* hsa-miR-221* hsa-miR-370
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEAR1 (see all 4)
    OriGene shRNA RFP: PEAR1
    OriGene siRNA: PEAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEAR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PEAR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEAR1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEAR1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PEAR1 (NM_001080471)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEAR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PEAR1
    Search LifeMap BioReagents cell lines for PEAR1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEAR1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    PEAR1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PEAR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PEAR1 (ENSP000002923574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP10ENSP000003165894STRING: ENSP00000316589
    SNRNP200ENSP000003171234STRING: ENSP00000317123
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043654recognition of apoptotic cell IEA--


    PEAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PEAR1
    Search CenterWatch for drugs/clinical trials and news about PEAR1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PEAR1 gene (2 alternative transcripts): 
    NM_001080471.1  NM_207369.1  

    Unigene Cluster for PEAR1:

    Platelet endothelial aggregation receptor 1
    Hs.142003  [show with all ESTs]
    Unigene Representative Sequence: NM_001080471
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444016 ENST00000338302 ENST00000455314 ENST00000469390(uc001fqk.1)
    ENST00000482505 ENST00000465101 ENST00000292357(uc009wsl.1 uc001fqj.1)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PEAR1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEAR1
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PEAR1 (see all 11):
    hsa-miR-485-5p hsa-miR-1206 hsa-miR-24-1* hsa-miR-4268 hsa-miR-1291 hsa-miR-24-2* hsa-miR-221* hsa-miR-370
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEAR1 (see all 4)
    OriGene shRNA RFP: PEAR1
    OriGene siRNA: PEAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEAR1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEAR1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEAR1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PEAR1 (NM_001080471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEAR1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEAR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PEAR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEAR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEAR1

    Additional cDNA sequence: 

    AK074121.1 AK098809.1 

    4 DOTS entries:

    DT.100747264  DT.421851  DT.100747265  DT.92034522 

    24/72 AceView cDNA sequences (see all 72):

    BG005293 AA515689 AI123863 CB409465 BM989236 AW237134 BM724776 AW302445 
    AI625773 BX090671 CR609390 BE502716 AI697757 AI160078 BU785495 AA132043 
    AK074121 BU741416 CR599082 AW594288 AL040177 CN482654 N80839 AL039412 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PEAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCGCACCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PEAR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PEAR1

    SOURCE GeneReport for Unigene cluster: Hs.142003

    UniProtKB/Swiss-Prot: PEAR1_HUMAN, Q5VY43
    Tissue specificity: Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart,
    kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion,
    endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells.
    Weakly expressed in peripheral blood leukocytes and macrophages

        SABiosciences Custom PCR Arrays for PEAR1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEAR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PEAR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEAR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEAR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PEAR1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PEAR11 platelet endothelial aggregation receptor 1 64.5(n)
    57.3(a)
      100857779  XM_003642625.1  XP_003642673.1 
    lizard
    (Anolis carolinensis)
    Reptilia PEAR16
    --
    53(a)
    1 ↔ 1
    GL343640.1(144415-170343)
    zebrafish
    (Danio rerio)
    Actinopterygii pear11 platelet endothelial aggregation receptor 1 56.97(n)
    51.48(a)
      571812  XM_695441.4  XP_700533.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta drpr6
    draper
    24(a)
    1 → many
    3L(1715595-1731107)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-16
    Cell death abnormality protein 1
    22(a)
    possible ortholog
    I(11851334-11868096)


    ENSEMBL Gene Tree for PEAR1 (if available)
    TreeFam Gene Tree for PEAR1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PEAR1 gene
    NAGPA2  STAB22  STAB12  MEGF102  SCARF22  MEGF62  MEGF112  TNFAIP62  
    SCARF12  
    4 SIMAP similar genes for PEAR1 using alignment to 3 protein entries:     PEAR1_HUMAN (see all proteins):
    MEGF10    MEGF11    SCARF1    MEGF6

    PEAR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/557 NCBI SNPs in PEAR1 are shown (see all 557    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75481811,2
    C,F,H,--156861531(+) tttatT/Cgtatg 1 -- us2k15Minor allele frequency- C:0.04NS EA WA 536
    rs1436383381,2
    --156861556(+) ATACAG/TTTGAG 1 -- us2k10--------
    rs29867161,2
    C,F,H,--156861589(+) ATGATC/ACTGCT 1 -- us2k120Minor allele frequency- A:0.26NS EA NA WA CSA 1204
    rs753373131,2
    C,--156861678(+) CAGACC/TTCGGT 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs1481199941,2
    --156861771(+) GAGCCC/TAGGAA 1 -- us2k10--------
    rs46610661,2
    C,A,H,--156861808(+) GAAACA/CCCATC 1 -- us2k18Minor allele frequency- C:0.06NA WA CSA 16
    rs1822564751,2
    --156861839(+) TAGCCA/TGACGT 1 -- us2k10--------
    rs1456346271,2
    C,--156861849(+) TGTGG-/GCGCGCG 1 -- us2k10--------
    rs115864611,2
    H--156861850(+) gtgggC/Ggcgcg 1 -- us2k10--------
    rs668633281,2
    C,--156861855(+) CGCGC-/GCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PEAR1 (156863490 - 156886226 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PEAR1: --
    Human Gene Mutation Database (HGMD): PEAR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PEAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for PEAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PEAR1 for disorders           About GeneDecksing

    OMIM gene information: 610278    OMIM disorders: --

    1 disease for PEAR1:    About MalaCards
    dysentery

    Human Genome Epidemiology (HuGE) Navigator: PEAR1 (3 documents)

    Export disorders for PEAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PEAR1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PEAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. (PubMed id 15851471)1, 2, 3, 9 Nanda N.... Hart M.J. (2005)
    2. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. (PubMed id 18511696)1, 9 Herrera-Galeano J.E....Becker L.C. (2008)
    3. Identification of a specific intronic PEAR1 gene vari ant associated with greater platelet aggregability and protein expression. (PubMed id 21791418)1 Faraday N....Becker L.C. (2011)
    4. Genome-wide meta-analyses identifies seven loci assoc iated with platelet aggregation in response to agonists. (PubMed id 20526338)1 Johnson A.D....Becker L.C. (2010)
    5. A functional genomics approach reveals novel quantitative trait loci associated with platelet signalling pathways. (PubMed id 19429868)1 Jones C.I....Ouwehand W.H. (2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375033 HGNC: 33631 AceView: FLJ00193 Ensembl:ENSG00000187800 euGenes: HUgn375033
    ECgene: PEAR1 H-InvDB: PEAR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PEAR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PEAR1 gene:
    Search GeneIP for patents involving PEAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PEAR1 (PEAR1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for PEAR1 (PEAR1)  
     Browse OriGene Antibodies   OriGene shRNA RFP for PEAR1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEAR1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEAR1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PEAR1   OriGene 3'-UTR Clone for PEAR1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEAR1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEAR1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PEAR1   OriGene Custom Protein Services for PEAR1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PEAR1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PEAR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEAR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEAR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEAR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEAR1
     GenScript Custom Purified and Recombinant Proteins Services for PEAR1 GenScript cDNA clones with any tag delivered in your preferred vector for PEAR1
     GenScript Custom Assay Services for PEAR1 GenScript Custom Superior Antibodies Services for PEAR1
     GenScript Custom overexpressing Cell Line Services for PEAR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PEAR1 promoter
     Search Chromatin IP Primers for PEAR1
     RT2 qPCR Primer Assay in human, mouse, rat PEAR1
     Search GNC Networks for PEAR1
     SABiosciences Custom PCR Arrays for PEAR1
     Search Tocris compounds for PEAR1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PEAR1 antibodies
     Search for Antibodies for PEAR1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PEAR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PEAR1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PEAR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEAR1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PEAR1
     Browse SwitchGear Promoter luciferase reporter plasmids for PEAR1
     ThermoFisher Antibodies for PEAR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEAR1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PEAR1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4