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Aliases for PEAK3 Gene

Aliases for PEAK3 Gene

  • PEAK Family Member 3 2 3
  • C19orf35 3 4 5
  • Chromosome 19 Open Reading Frame 35 2 5
  • Putative Uncharacterized Protein C19orf35 3

External Ids for PEAK3 Gene

Previous HGNC Symbols for PEAK3 Gene

  • C19orf35

Summaries for PEAK3 Gene

GeneCards Summary for PEAK3 Gene

PEAK3 (PEAK Family Member 3) is a Protein Coding gene. An important paralog of this gene is PEAK1.

Additional gene information for PEAK3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEAK3 Gene

Genomics for PEAK3 Gene

Regulatory Elements for PEAK3 Gene

Enhancers for PEAK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H002615 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -342.5 -342519 17 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF77 GADD45B SF3A2 RNU6-993P GNA11 SLC39A3 PEAK3 CACTIN-AS1 TLE2 DOT1L
GH19H002038 2.2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +231.2 231157 24 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF77 SF3A2 CIRBP ZNF555 DAZAP1 MUM1 MKNK2 TCF3 LMNB2 BTBD2
GH19H002598 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -317.2 -317156 1 HDGF FOXA2 PKNOX1 ATF1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 RNU6-993P SLC39A3 PEAK3 LSM7 SPPL2B GADD45B DOT1L RN7SL121P ENSG00000267412
GH19H002287 0.8 FANTOM5 dbSUPER 21.1 -5.7 -5702 0 BCOR HDAC2 ZMYM3 KDM1A PEAK3 CSNK1G2 MOB3A MKNK2 KLF16 DOT1L OAZ1 GC19M002288
GH19H002079 1.8 FANTOM5 ENCODE dbSUPER 8.4 +193.3 193330 18 MLX DMAP1 YBX1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 RCOR2 SF3A2 CIRBP ZNF77 BTBD2 MKNK2 ZNF555 LMNB2 ENSG00000268798 RPS15 MOB3A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PEAK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PEAK3 Gene

Chromosome:
19
Start:
2,274,622 bp from pter
End:
2,282,182 bp from pter
Size:
7,561 bases
Orientation:
Minus strand

Genomic View for PEAK3 Gene

Genes around PEAK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEAK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEAK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEAK3 Gene

Proteins for PEAK3 Gene

  • Protein details for PEAK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS72-CS035_HUMAN
    Recommended name:
    Putative uncharacterized protein C19orf35
    Protein Accession:
    Q6ZS72

    Protein attributes for PEAK3 Gene

    Size:
    473 amino acids
    Molecular mass:
    50509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PEAK3 Gene

Post-translational modifications for PEAK3 Gene

No Post-translational modifications

Other Protein References for PEAK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PEAK3 Gene

Domains & Families for PEAK3 Gene

Gene Families for PEAK3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PEAK3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PEAK3: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PEAK3 Gene

Function for PEAK3 Gene

Phenotypes From GWAS Catalog for PEAK3 Gene

Gene Ontology (GO) - Molecular Function for PEAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
genes like me logo Genes that share ontologies with PEAK3: view
genes like me logo Genes that share phenotypes with PEAK3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PEAK3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PEAK3 Gene

Localization for PEAK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PEAK3 gene
Compartment Confidence
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PEAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IBA --
GO:0015629 actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with PEAK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PEAK3 Gene

Pathways & Interactions for PEAK3 Gene

SuperPathways for PEAK3 Gene

No Data Available

Interacting Proteins for PEAK3 Gene

Gene Ontology (GO) - Biological Process for PEAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PEAK3: view

No data available for Pathways by source and SIGNOR curated interactions for PEAK3 Gene

Drugs & Compounds for PEAK3 Gene

No Compound Related Data Available

Transcripts for PEAK3 Gene

mRNA/cDNA for PEAK3 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PEAK3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PEAK3 Gene

No ASD Table

Relevant External Links for PEAK3 Gene

GeneLoc Exon Structure for
PEAK3
ECgene alternative splicing isoforms for
PEAK3

Expression for PEAK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PEAK3 Gene:

PEAK3

Evidence on tissue expression from TISSUES for PEAK3 Gene

  • Blood(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PEAK3 Gene

Orthologs for PEAK3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PEAK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19orf35 34
  • 99 (a)
OneToOne
C19H19orf35 33
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia C7H19orf35 33
  • 78.55 (n)
C19orf35 34
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf35 33
  • 78.3 (n)
C19orf35 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf35 34
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf35 34
  • 43 (a)
OneToOne
Species where no ortholog for PEAK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PEAK3 Gene

ENSEMBL:
Gene Tree for PEAK3 (if available)
TreeFam:
Gene Tree for PEAK3 (if available)

Paralogs for PEAK3 Gene

Paralogs for PEAK3 Gene

genes like me logo Genes that share paralogs with PEAK3: view

Variants for PEAK3 Gene

Sequence variations from dbSNP and Humsavar for PEAK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000050406 -- 2,275,130(+) GTCCA(C/G)ACCCC utr-variant-3-prime
rs1000119915 -- 2,282,493(+) CCCAC(C/T)GTAGG upstream-variant-2KB
rs1000340300 -- 2,278,767(+) CCCTG(C/T)AGCTG reference, synonymous-codon
rs1000845893 -- 2,283,823(+) TCCCA(A/G)AATGC upstream-variant-2KB
rs1000921005 -- 2,274,347(+) GGGGT(C/T)GGAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PEAK3 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
esv2717882 CNV deletion 23290073
nsv578383 CNV loss 21841781
nsv833707 CNV loss 17160897

Variation tolerance for PEAK3 Gene

Gene Damage Index Score: 8.19; 84.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PEAK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PEAK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEAK3 Gene

Disorders for PEAK3 Gene

Relevant External Links for PEAK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PEAK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PEAK3

No disorders were found for PEAK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PEAK3 Gene

Publications for PEAK3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for PEAK3 Gene

Sources for PEAK3 Gene

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