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Aliases for PEA15 Gene

Aliases for PEA15 Gene

  • Phosphoprotein Enriched In Astrocytes 15 2 3 5
  • 15 KDa Phosphoprotein Enriched In Astrocytes 3 4
  • Phosphoprotein Enriched In Diabetes 3 4
  • Homolog Of Mouse MAT-1 Oncogene 2 3
  • PED 3 4
  • Mammary Transforming Gene 1, Mouse, Homolog Of 3
  • Phosphoprotein Enriched In Astrocytes 2
  • HUMMAT1H 3
  • PEA-15 3
  • HMAT1 3
  • MAT1H 3
  • MAT1 3
  • 15kD 2

External Ids for PEA15 Gene

Previous GeneCards Identifiers for PEA15 Gene

  • GC01P157967
  • GC01P155907
  • GC01P156952
  • GC01P157391
  • GC01P156990
  • GC01P158441
  • GC01P160175
  • GC01P131531

Summaries for PEA15 Gene

Entrez Gene Summary for PEA15 Gene

  • This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for PEA15 Gene

PEA15 (Phosphoprotein Enriched In Astrocytes 15) is a Protein Coding gene. Diseases associated with PEA15 include diabetes mellitus, noninsulin-dependent. Among its related pathways are Signaling by GPCR and Immune System.

UniProtKB/Swiss-Prot for PEA15 Gene

  • Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Gene Wiki entry for PEA15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEA15 Gene

Genomics for PEA15 Gene

Regulatory Elements for PEA15 Gene

Promoters for PEA15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PEA15 on UCSC Golden Path with GeneCards custom track

Genomic Location for PEA15 Gene

Chromosome:
1
Start:
160,205,319 bp from pter
End:
160,215,376 bp from pter
Size:
10,058 bases
Orientation:
Plus strand

Genomic View for PEA15 Gene

Genes around PEA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEA15 Gene

Proteins for PEA15 Gene

  • Protein details for PEA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15121-PEA15_HUMAN
    Recommended name:
    Astrocytic phosphoprotein PEA-15
    Protein Accession:
    Q15121
    Secondary Accessions:
    • B1AKZ3
    • O00511

    Protein attributes for PEA15 Gene

    Size:
    130 amino acids
    Molecular mass:
    15040 Da
    Quaternary structure:
    • Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.

    Three dimensional structures from OCA and Proteopedia for PEA15 Gene

    Alternative splice isoforms for PEA15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEA15 Gene

Proteomics data for PEA15 Gene at MOPED

Post-translational modifications for PEA15 Gene

  • Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PEA15 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PEA15 (PEA-15)

No data available for DME Specific Peptides for PEA15 Gene

Domains & Families for PEA15 Gene

Gene Families for PEA15 Gene

Protein Domains for PEA15 Gene

Graphical View of Domain Structure for InterPro Entry

Q15121

UniProtKB/Swiss-Prot:

PEA15_HUMAN :
  • Contains 1 DED (death effector) domain.
Domain:
  • Contains 1 DED (death effector) domain.
genes like me logo Genes that share domains with PEA15: view

Function for PEA15 Gene

Molecular function for PEA15 Gene

GENATLAS Biochemistry:
major astrocyte phosphoprotein PEA-15,murine mammary transforming gene (MAT1) homolog,15kDa,overexpressed in some breast cancer lines,controlling glucose transport
UniProtKB/Swiss-Prot Function:
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
genes like me logo Genes that share phenotypes with PEA15: view

Animal Models for PEA15 Gene

MGI Knock Outs for PEA15:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PEA15 Gene

Localization for PEA15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEA15 Gene

Cytoplasm. Note=Associated with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEA15 Gene COMPARTMENTS Subcellular localization image for PEA15 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PEA15 Gene

Pathways & Interactions for PEA15 Gene

SuperPathways for PEA15 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 Signal transduction_Erk Interactions- Inhibition of Erk
genes like me logo Genes that share pathways with PEA15: view

Pathways by source for PEA15 Gene

SIGNOR curated interactions for PEA15 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PEA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IEA --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0006810 transport TAS 9670003
genes like me logo Genes that share ontologies with PEA15: view

Drugs & Compounds for PEA15 Gene

(1) Drugs for PEA15 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for PEA15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PEA15: view

Transcripts for PEA15 Gene

Unigene Clusters for PEA15 Gene

Phosphoprotein enriched in astrocytes 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEA15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8
SP1: -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - -
SP8: - - - - - -

Relevant External Links for PEA15 Gene

GeneLoc Exon Structure for
PEA15
ECgene alternative splicing isoforms for
PEA15

Expression for PEA15 Gene

mRNA expression in normal human tissues for PEA15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEA15 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.6).

Protein differential expression in normal tissues from HIPED for PEA15 Gene

This gene is overexpressed in Brain (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEA15 Gene



SOURCE GeneReport for Unigene cluster for PEA15 Gene Hs.517216

mRNA Expression by UniProt/SwissProt for PEA15 Gene

Q15121-PEA15_HUMAN
Tissue specificity: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
genes like me logo Genes that share expression patterns with PEA15: view

Protein tissue co-expression partners for PEA15 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PEA15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PEA15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEA15 35
  • 99.74 (n)
  • 100 (a)
PEA15 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEA15 36
  • 100 (a)
OneToOne
PEA15 35
  • 95.38 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PEA15 35
  • 90.26 (n)
  • 94.62 (a)
PEA15 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pea15a 35
  • 94.87 (n)
  • 99.23 (a)
Pea15a 16
Pea15a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PEA15 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PEA15 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pea15 35
  • 96.15 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pea15 35
  • 73.15 (n)
  • 79.63 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557745 35
  • 72.82 (n)
  • 77.69 (a)
PEA15 36
  • 78 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4988 36
  • 31 (a)
OneToOne
Species with no ortholog for PEA15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PEA15 Gene

ENSEMBL:
Gene Tree for PEA15 (if available)
TreeFam:
Gene Tree for PEA15 (if available)

Paralogs for PEA15 Gene

Pseudogenes.org Pseudogenes for PEA15 Gene

genes like me logo Genes that share paralogs with PEA15: view

No data available for Paralogs for PEA15 Gene

Variants for PEA15 Gene

Sequence variations from dbSNP and Humsavar for PEA15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs625876 -- 160,210,965(-) TGGAT(A/G)GATGC intron-variant
rs8175359 -- 160,213,310(+) GTCCC(A/G)TTGAC intron-variant
rs8192602 -- 160,211,719(+) AAGGT(A/C/G/T)GGGGA intron-variant
rs12040700 -- 160,214,285(+) CCTTA(G/T)GTTTT nc-transcript-variant, utr-variant-3-prime
rs11552712 -- 160,213,548(+) ATCCT(C/G)CAGGA nc-transcript-variant, utr-variant-3-prime

Variation tolerance for PEA15 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PEA15 Gene

HapMap Linkage Disequilibrium report
PEA15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PEA15 Gene

Disorders for PEA15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PEA15 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards
Search PEA15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PEA15

Genetic Association Database (GAD)
PEA15
Human Genome Epidemiology (HuGE) Navigator
PEA15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PEA15
genes like me logo Genes that share disorders with PEA15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEA15 Gene

Publications for PEA15 Gene

  1. Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. (PMID: 10607908) Wolford J.K. … Prochazka M. (Gene 2000) 3 4 48 67
  2. Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers. (PMID: 9205133) Hwang S. … Collins C.C. (Genomics 1997) 2 3 23
  3. Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. (PMID: 20032303) Haling J.R. … Ginsberg M.H. (Mol. Biol. Cell 2010) 3 23
  4. Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene. (PMID: 20396999) Ungaro P. … Beguinot F. (Diabetologia 2010) 3 23
  5. Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15). (PMID: 19382910) Obradovic D. … Rein T. (J. Cell. Mol. Med. 2009) 3 23

Products for PEA15 Gene

Sources for PEA15 Gene

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