Aliases for PEA15 Gene
External Ids for PEA15 Gene
Previous GeneCards Identifiers for PEA15 Gene
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for PEA15 Gene
PEA15 (Phosphoprotein Enriched In Astrocytes 15) is a Protein Coding gene. Diseases associated with PEA15 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR.
UniProtKB/Swiss-Prot for PEA15 Gene
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.