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PDZRN4 Gene

protein-coding   GIFtS: 51
GCID: GC12P041582

PDZ Domain Containing Ring Finger 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PDZ Domain Containing Ring Finger 41 2     IMAGE57675892
Ligand Of Numb Protein X 42 3     SAMCAP3L2
LNX42 3     PDZ Domain-Containing RING Finger Protein 42
SEMACAP3-Like Protein2 3     SEMCAP3L3
Similar To SemaF Cytoplasmic Domain Associated Protein 31     

External Ids:    HGNC: 305521   Entrez Gene: 299512   Ensembl: ENSG000001659667   OMIM: 6097305   UniProtKB: Q6ZMN73   

Export aliases for PDZRN4 gene to outside databases

Previous GC identifers: GC12P040117 GC12P039868 GC12P038608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PDZRN4 Gene:
PDZRN4 (PDZ domain containing ring finger 4) is a protein-coding gene. Diseases associated with PDZRN4 include amyotrophic lateral sclerosis, and lateral sclerosis. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is PDZRN3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDZRN4 gene promoter:
         FOXD3   RelA   Nkx2-5   NF-kappaB   MEF-2A   HNF-1   FOXO4   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDZRN4 promoter sequence
   Search Chromatin IP Primers for PDZRN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDZRN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

PDZRN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDZRN4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P041582:  view genomic region     (about GC identifiers)

Start:
41,582,250 bp from pter      End:
41,968,392 bp from pter
Size:
386,143 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PZRN4_HUMAN, Q6ZMN7 (See protein sequence)
Recommended Name: PDZ domain-containing RING finger protein 4  
Size: 1036 amino acids; 117103 Da
Secondary accessions: Q52LY3 Q52LY4 Q6N052 Q8IUU1 Q9NTP7
Alternative splicing: 3 isoforms:  Q6ZMN7-1   Q6ZMN7-2   Q6ZMN7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDZRN4: NX_Q6ZMN7

Explore proteomics data for PDZRN4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PDZRN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158067.1  NP_037509.3  

    ENSEMBL proteins: 
     ENSP00000384197   ENSP00000439990   ENSP00000298919  

    PDZRN4 Human Recombinant Protein Products:

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    Novus Biologicals PDZRN4 Protein
    Novus Biologicals PDZRN4 Lysates
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    Cloud-Clone Corp. Proteins for PDZRN4

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    LSBio Antibodies in human, mouse, rat for PDZRN4

    PDZRN4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PDZRN4
    Cloud-Clone Corp. CLIAs for PDZRN4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 6):
     IPR008974 TRAF-like
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q6ZMN7

    ProtoNet protein and cluster: Q6ZMN7

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: PZRN4_HUMAN, Q6ZMN7
    Similarity: Contains 2 PDZ (DHR) domains
    Similarity: Contains 1 RING-type zinc finger


    PDZRN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    PDZRN4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDZRN4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDZRN4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDZRN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDZRN4:
    hsa-mir-128-3p (MIRT021946)

    Block miRNA regulation of human, mouse, rat PDZRN4 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PDZRN4:
    hsa-miR-3163 hsa-miR-539 hsa-miR-32* hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidPDZRN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDZRN4
    Predesigned siRNA for gene silencing in human, mouse, rat PDZRN4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDZRN4

    Clone
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    OriGene clones in human, mouse for PDZRN4 (see all 12)
    OriGene ORF clones in mouse, rat for PDZRN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDZRN4 (NM_013377)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDZRN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZRN4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PDZRN4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZRN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PDZRN4: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PDZRN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PDZRN4 (Q6ZMN73 ENSP000002989194) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    KCNMA1ENSP000002866274STRING: ENSP00000286627
    KCNU1ENSP000003827704STRING: ENSP00000382770
    ACTN1ENSP000003779414STRING: ENSP00000377941
    ACTN2ENSP000003555374STRING: ENSP00000355537
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDZRN4 (PZRN4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PDZRN4 gene (2 alternative transcripts): 
    NM_001164595.1  NM_013377.3  

    Unigene Cluster for PDZRN4:

    PDZ domain containing ring finger 4
    Hs.380044  [show with all ESTs]
    Unigene Representative Sequence: NM_001164595
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402685(uc010skn.2) ENST00000539469 ENST00000298919(uc001rmq.4 uc009zjz.3)
    ENST00000548316(uc001rmr.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDZRN4 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PDZRN4:
    hsa-miR-3163 hsa-miR-539 hsa-miR-32* hsa-miR-1256
    SwitchGear 3'UTR luciferase reporter plasmidPDZRN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDZRN4
    Predesigned siRNA for gene silencing in human, mouse, rat PDZRN4
    Clone
    Products:
         
    OriGene clones in human, mouse for PDZRN4 (see all 12)
    OriGene ORF clones in mouse, rat for PDZRN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDZRN4 (NM_013377)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDZRN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZRN4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PDZRN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDZRN4
      QuantiTect SYBR Green Assays in human, mouse, rat PDZRN4
      QuantiFast Probe-based Assays in human, mouse, rat PDZRN4

    Additional mRNA sequence: 

    AK091096.1 AK094690.1 AK131554.1 AK294431.1 AK294535.1 AL133067.1 BC040922.1 BC093744.1 
    BC093746.2 BX640695.1 

    6 DOTS entries:

    DT.75184928  DT.40250224  DT.95354014  DT.91751576  DT.92048762  DT.95347479 

    16 AceView cDNA sequences:

    BQ723296 AW051272 BM926757 AK094690 AK131554 BQ718132 NM_013377 BC040922 
    AL133067 CD516555 BX640695 AK091096 R37079 AX746777 BQ432575 AA331484 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PDZRN4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                        
    SP2:              -     -                                                   


    ECgene alternative splicing isoforms for PDZRN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDZRN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCTAGATA
    PDZRN4 Expression
    About this image


    PDZRN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Long Bone
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Medulla Oblongata
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Neural Tube (Nervous System)
             Metencephalon
    PDZRN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDZRN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380044
        Pathway & Disease-focused RT2 Profiler PCR Array including PDZRN4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PDZRN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDZRN4
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    QuantiFast Probe-based Assays in human, mouse, rat PDZRN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZRN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PDZRN4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdzrn41 , 5 PDZ domain containing RING finger 41, 5 84.41(n)1
    86.6(a)1
      15 (46.53 cM)5
    2396181  NM_001164593.11  NP_001158065.11 
     923969155 
    chicken
    (Gallus gallus)
    Aves PDZRN41 PDZ domain containing RING finger 4 81.13(n)
    87.47(a)
      417787  XM_416030.4  XP_416030.4 
    lizard
    (Anolis carolinensis)
    Reptilia PDZRN46
    PDZ domain containing ring finger 4
    81(a)
    1 ↔ 1
    5(55663464-55800799)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pdzrn41 PDZ domain containing ring finger 4 73.47(n)
    77.98(a)
      100487445  XM_002932810.2  XP_002932856.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdzrn41 PDZ domain containing ring finger 4 59.63(n)
    59.44(a)
      798289  NM_001082923.2  NP_001076392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Slip16
    Slip1
    17(a)
    1 → many
    4(684214-690510)
    worm
    (Caenorhabditis elegans)
    Secernentea C50F7.66
    Protein C50F7.6 (C50F7.6) mRNA, complete cds
    26(a)
    1 → many
    IV(7720566-7723199) WBGene00016846


    ENSEMBL Gene Tree for PDZRN4 (if available)
    TreeFam Gene Tree for PDZRN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDZRN4 gene
    PDZRN32  PDZD42  
    7 SIMAP similar genes for PDZRN4 using alignment to 1 protein entry:     PZRN4_HUMAN:
    PDZRN3    PDZD4    DLG4    TAX1BP3    TJP2    RNF41
    SYNJ2BP

    PDZRN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDZRN4 (see all 8380)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359514
    A colorectal cancer sample4--see VAR_0359512 G R mis40--------
    rs113926941,2
    C--41580288(+) TTTTTT/-TCCAA 1 -- us2k1 tfbs3 trp31Minor allele frequency- -:0.50NA 2
    rs612696721,2
    C--41580299(+) TTTTT-/T/TT  
            
    CCAAG
    1 -- us2k10--------
    rs731170671,2
    C--41580299(+) TTTTTT/CCCAAG 1 -- us2k14Minor allele frequency- C:0.07CSA WA NA EA 360
    rs73032851,2
    C,F,A,H--41580346(+) CAAAAG/TAATAT 1 -- us2k1 tfbs323Minor allele frequency- T:0.44NS EA NA WA CSA 2352
    rs1502143751,2
    C--41580381(+) CTTTTG/TAAAAA 1 -- us2k10--------
    rs1387803871,2
    --41580394(+) CTGTCA/GGTGTC 1 -- us2k10--------
    rs1861134471,2
    --41580503(+) TTCTAC/TAGCTA 1 -- us2k10--------
    rs1149791521,2
    C,F--41580634(+) AATCAG/ATAATT 1 -- us2k12Minor allele frequency- A:0.02WA EA 238
    rs1420595921,2
    C--41580758(+) ATAGCA/TTCTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDZRN4 (41582250 - 41832250 bp, first 250kb of PDZRN4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDZRN4 (see all 41):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5085CNV Deletion18987735
    esv2661468CNV Deletion23128226
    esv2745815CNV Deletion23290073
    esv2627708CNV Deletion19546169
    esv2745811CNV Deletion23290073
    esv2677208CNV Deletion23128226
    esv2745814CNV Deletion23290073
    esv2745812CNV Deletion23290073
    esv1158500CNV Deletion17803354
    esv1562276CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDZRN4
    DNA2.0 Custom Variant and Variant Library Synthesis for PDZRN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609730    OMIM disorders: --

    7 diseases for PDZRN4:    
    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    breast and colorectal cancer    multiple sclerosis
    parkinson's disease    colorectal cancer    endotheliitis


    PDZRN4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PDZRN4
    Human Genome Epidemiology (HuGE) Navigator: PDZRN4 (1 document)

    Export disorders for PDZRN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDZRN4 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PDZRN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of PDZRN3 and PDZRN4 genes in silico. (PubMed id 15010864)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1, 4 Baranzini S.E....Oksenberg J.R. (Hum. Mol. Genet. 2009)
    4. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    9. Replication of top markers of a genome-wide association study in multiple sclerosis in Spain. (PubMed id 20944657)1 Cavanillas M.L....Urcelay E. (Genes Immun. 2011)
    10. Genome-wide association study of biochemical traits in Korcula Island, Croatia. (PubMed id 19260141)4 Zemunik T....Rudan I. (Croat. Med. J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29951 HGNC: 30552 AceView: PDZRN4 Ensembl:ENSG00000165966 euGenes: HUgn29951
    ECgene: PDZRN4 H-InvDB: PDZRN4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDZRN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDZRN4 gene:
    Search GeneIP for patents involving PDZRN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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