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Aliases for PDZRN4 Gene

Aliases for PDZRN4 Gene

  • PDZ Domain Containing Ring Finger 4 2 3
  • Ligand Of Numb Protein X 4 3 4
  • SEMACAP3-Like Protein 3 4
  • LNX4 3 4
  • Similar To SemaF Cytoplasmic Domain Associated Protein 3 2
  • PDZ Domain-Containing RING Finger Protein 4 3
  • IMAGE5767589 3
  • SAMCAP3L 3
  • SEMCAP3L 4

External Ids for PDZRN4 Gene

Previous GeneCards Identifiers for PDZRN4 Gene

  • GC12P040117
  • GC12P039868
  • GC12P041582
  • GC12P038608

Summaries for PDZRN4 Gene

GeneCards Summary for PDZRN4 Gene

PDZRN4 (PDZ Domain Containing Ring Finger 4) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is PDZRN3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDZRN4 Gene

Genomics for PDZRN4 Gene

Regulatory Elements for PDZRN4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDZRN4 Gene

41,188,397 bp from pter
41,574,590 bp from pter
386,194 bases
Plus strand

Genomic View for PDZRN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDZRN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDZRN4 Gene

Proteins for PDZRN4 Gene

  • Protein details for PDZRN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PDZ domain-containing RING finger protein 4
    Protein Accession:
    Secondary Accessions:
    • Q52LY3
    • Q52LY4
    • Q6N052
    • Q8IUU1
    • Q9NTP7

    Protein attributes for PDZRN4 Gene

    1036 amino acids
    Molecular mass:
    117103 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PDZRN4 Gene


neXtProt entry for PDZRN4 Gene

Proteomics data for PDZRN4 Gene at MOPED

Post-translational modifications for PDZRN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDZRN4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PDZRN4

No data available for DME Specific Peptides for PDZRN4 Gene

Domains for PDZRN4 Gene

Gene Families for PDZRN4 Gene

Protein Domains for PDZRN4 Gene

Suggested Antigen Peptide Sequences for PDZRN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PDZ (DHR) domains.
  • Contains 1 RING-type zinc finger.
  • Contains 2 PDZ (DHR) domains.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PDZRN4: view

Function for PDZRN4 Gene

Gene Ontology (GO) - Molecular Function for PDZRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with PDZRN4: view

Animal Model Products

CRISPR Products

miRNA for PDZRN4 Gene

miRTarBase miRNAs that target PDZRN4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDZRN4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PDZRN4 Gene

Localization for PDZRN4 Gene

Subcellular locations from

Jensen Localization Image for PDZRN4 Gene COMPARTMENTS Subcellular localization image for PDZRN4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PDZRN4 Gene

Pathways for PDZRN4 Gene

SuperPathways for PDZRN4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PDZRN4 Gene

Gene Ontology (GO) - Biological Process for PDZRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with PDZRN4: view

No data available for Pathways by source for PDZRN4 Gene

Transcripts for PDZRN4 Gene

mRNA/cDNA for PDZRN4 Gene

Unigene Clusters for PDZRN4 Gene

PDZ domain containing ring finger 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDZRN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDZRN4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP2: - -

Relevant External Links for PDZRN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDZRN4 Gene

mRNA expression in normal human tissues for PDZRN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDZRN4 Gene

This gene is overexpressed in Colon - Sigmoid (6.2), Artery - Tibial (5.9), and Nerve - Tibial (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PDZRN4 Gene

SOURCE GeneReport for Unigene cluster for PDZRN4 Gene Hs.380044

genes like me logo Genes that share expressions with PDZRN4: view

Expression partners for PDZRN4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PDZRN4 Gene

Orthologs for PDZRN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDZRN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PDZRN4 35
  • 88.15 (n)
  • 91.15 (a)
  • 87 (a)
(Mus musculus)
Mammalia Pdzrn4 35
  • 84.41 (n)
  • 86.6 (a)
Pdzrn4 16
Pdzrn4 36
  • 75 (a)
(Pan troglodytes)
Mammalia PDZRN4 35
  • 99.36 (n)
  • 99.52 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pdzrn4 35
  • 85.1 (n)
  • 88.62 (a)
(Bos Taurus)
Mammalia PDZRN4 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia PDZRN4 36
  • 83 (a)
(Gallus gallus)
Aves PDZRN4 35
  • 81.13 (n)
  • 87.47 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia PDZRN4 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdzrn4 35
  • 73.47 (n)
  • 77.98 (a)
(Danio rerio)
Actinopterygii pdzrn4 35
  • 59.63 (n)
  • 59.44 (a)
pdzrn4 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Slip1 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea C50F7.6 36
  • 26 (a)
Species with no ortholog for PDZRN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDZRN4 Gene

Gene Tree for PDZRN4 (if available)
Gene Tree for PDZRN4 (if available)

Paralogs for PDZRN4 Gene

Paralogs for PDZRN4 Gene

(7) SIMAP similar genes for PDZRN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PDZRN4: view

Variants for PDZRN4 Gene

Sequence variations from dbSNP and Humsavar for PDZRN4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs157971 -- 41,563,766(+) TATCA(C/T)GGTTA intron-variant
rs157972 -- 41,559,022(+) AATGA(A/G)TCCCT intron-variant
rs157973 -- 41,558,993(+) CTTAA(A/G)GTTTC intron-variant
rs158190 -- 41,559,655(+) CAACA(C/G)GACTT intron-variant
rs169564 -- 41,527,676(+) CCAAA(A/G)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDZRN4 Gene

Variant ID Type Subtype PubMed ID
nsv899034 CNV Gain 21882294
nsv899035 CNV Loss 21882294
nsv517338 CNV Loss 19592680
esv2648805 CNV Deletion 19546169
esv2745809 CNV Deletion 23290073
esv2204947 CNV Deletion 18987734
esv3999 CNV Deletion 18987735
nsv52593 CNV Loss 16902084
esv2745810 CNV Deletion 23290073
esv991188 CNV Deletion 20482838
esv5502 CNV Loss 19470904
esv1562276 CNV Deletion 17803354
esv2745811 CNV Deletion 23290073
esv2661468 CNV Deletion 23128226
esv29365 CNV Loss 19812545
nsv832383 CNV Gain 17160897
nsv826348 CNV Loss 20364138
esv2745812 CNV Deletion 23290073
esv5085 CNV Deletion 18987735
esv1009674 CNV Deletion 20482838
esv1158500 CNV Deletion 17803354
esv2745813 CNV Deletion 23290073
nsv832384 CNV Gain 17160897
dgv1417n71 CNV Gain 21882294
dgv1418n71 CNV Gain 21882294
dgv507e1 CNV Complex 17122850
nsv818915 CNV Gain 17921354
esv2487088 CNV Insertion 19546169
esv269469 CNV Insertion 20981092
esv273115 CNV Insertion 20981092
esv994358 CNV Insertion 20482838
esv1471392 CNV Insertion 17803354
esv2012474 CNV Deletion 18987734
esv2627708 CNV Deletion 19546169
nsv826349 CNV Loss 20364138
esv2677208 CNV Deletion 23128226
esv2745814 CNV Deletion 23290073
esv2657522 CNV Deletion 23128226
esv2745815 CNV Deletion 23290073
nsv899040 CNV Gain 21882294
nsv832385 CNV Loss 17160897

Relevant External Links for PDZRN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDZRN4 Gene

Disorders for PDZRN4 Gene

Relevant External Links for PDZRN4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PDZRN4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PDZRN4 Gene

Publications for PDZRN4 Gene

  1. Identification and characterization of PDZRN3 and PDZRN4 genes in silico. (PMID: 15010864) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4

Products for PDZRN4 Gene

Sources for PDZRN4 Gene

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