Aliases for PDZRN3 Gene
External Ids for PDZRN3 Gene
Previous GeneCards Identifiers for PDZRN3 Gene
This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for PDZRN3 Gene
PDZRN3 (PDZ Domain Containing Ring Finger 3) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is PDZD4.
UniProtKB/Swiss-Prot for PDZRN3 Gene
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity).