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Aliases for PDZD8 Gene

Aliases for PDZD8 Gene

  • PDZ Domain Containing 8 2 3 5
  • Sarcoma Antigen NY-SAR-84/NY-SAR-104 3 4
  • PDZK8 3 4

External Ids for PDZD8 Gene

Previous HGNC Symbols for PDZD8 Gene

  • PDZK8

Previous GeneCards Identifiers for PDZD8 Gene

  • GC10M119033
  • GC10M112670

Summaries for PDZD8 Gene

GeneCards Summary for PDZD8 Gene

PDZD8 (PDZ Domain Containing 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PDZD8 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage. May promote retroviral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDZD8 Gene

Genomics for PDZD8 Gene

Regulatory Elements for PDZD8 Gene

Promoters for PDZD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDZD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDZD8 Gene

Chromosome:
10
Start:
117,277,274 bp from pter
End:
117,375,467 bp from pter
Size:
98,194 bases
Orientation:
Minus strand

Genomic View for PDZD8 Gene

Genes around PDZD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDZD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDZD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDZD8 Gene

Proteins for PDZD8 Gene

  • Protein details for PDZD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEN9-PDZD8_HUMAN
    Recommended name:
    PDZ domain-containing protein 8
    Protein Accession:
    Q8NEN9
    Secondary Accessions:
    • Q86WE0
    • Q86WE5
    • Q9UFF1

    Protein attributes for PDZD8 Gene

    Size:
    1154 amino acids
    Molecular mass:
    128563 Da
    Quaternary structure:
    • Interacts with MSN. Interacts with HIV-1 Gag polyprotein p55.
    SequenceCaution:
    • Sequence=AAO65182.1; Type=Frameshift; Positions=421; Evidence={ECO:0000305};

neXtProt entry for PDZD8 Gene

Proteomics data for PDZD8 Gene at MOPED

Post-translational modifications for PDZD8 Gene

  • Ubiquitination at Lys 49 and Lys 158
  • Modification sites at PhosphoSitePlus

Other Protein References for PDZD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDZD8 Gene

Domains & Families for PDZD8 Gene

Gene Families for PDZD8 Gene

Protein Domains for PDZD8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PDZD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEN9

UniProtKB/Swiss-Prot:

PDZD8_HUMAN :
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 PDZ (DHR) domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with PDZD8: view

Function for PDZD8 Gene

Molecular function for PDZD8 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage. May promote retroviral infection.

Phenotypes for PDZD8 Gene

genes like me logo Genes that share phenotypes with PDZD8: view

Animal Model Products

miRNA for PDZD8 Gene

miRTarBase miRNAs that target PDZD8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDZD8 Gene

Localization for PDZD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDZD8 Gene COMPARTMENTS Subcellular localization image for PDZD8 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PDZD8 Gene

Pathways & Interactions for PDZD8 Gene

SuperPathways for PDZD8 Gene

No Data Available

Interacting Proteins for PDZD8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000334642%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000334642 for PDZD8 Gene via STRING

Gene Ontology (GO) - Biological Process for PDZD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with PDZD8: view

No data available for Pathways by source and SIGNOR curated interactions for PDZD8 Gene

Drugs & Compounds for PDZD8 Gene

(3) Additional Compounds for PDZD8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PDZD8: view

Transcripts for PDZD8 Gene

Unigene Clusters for PDZD8 Gene

PDZ domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDZD8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for PDZD8 Gene

GeneLoc Exon Structure for
PDZD8
ECgene alternative splicing isoforms for
PDZD8

Expression for PDZD8 Gene

mRNA expression in normal human tissues for PDZD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDZD8 Gene

This gene is overexpressed in Pancreas (13.4) and Fetal Brain (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDZD8 Gene



SOURCE GeneReport for Unigene cluster for PDZD8 Gene Hs.501149

genes like me logo Genes that share expression patterns with PDZD8: view

Protein tissue co-expression partners for PDZD8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PDZD8 Gene

Orthologs for PDZD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDZD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDZD8 35
  • 89 (n)
  • 89.83 (a)
PDZD8 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDZD8 35
  • 90.58 (n)
  • 90.29 (a)
PDZD8 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdzd8 35
  • 87.29 (n)
  • 87.35 (a)
Pdzd8 16
Pdzd8 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDZD8 35
  • 99.45 (n)
  • 99.57 (a)
PDZD8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdzd8 35
  • 86.71 (n)
  • 86.88 (a)
oppossum
(Monodelphis domestica)
Mammalia PDZD8 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDZD8 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDZD8 35
  • 70.83 (n)
  • 65.95 (a)
PDZD8 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDZD8 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdzd8 35
  • 63.89 (n)
  • 63.1 (a)
zebrafish
(Danio rerio)
Actinopterygii pdzd8 35
  • 60.86 (n)
  • 59.91 (a)
pdzd8 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10362 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C53B4.4 36
  • 19 (a)
OneToOne
Species with no ortholog for PDZD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDZD8 Gene

ENSEMBL:
Gene Tree for PDZD8 (if available)
TreeFam:
Gene Tree for PDZD8 (if available)

Paralogs for PDZD8 Gene

No data available for Paralogs for PDZD8 Gene

Variants for PDZD8 Gene

Sequence variations from dbSNP and Humsavar for PDZD8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs35664484 - 117,284,316(-) TGTAG(C/T)TACTA reference, missense
rs363294 - 117,284,043(+) CTATT(C/T)GCCTA reference, missense
rs2848 -- 117,280,601(+) GCTTT(G/T)TACCT utr-variant-3-prime
rs363286 -- 117,280,226(+) TTGTC(G/T)AAGCC downstream-variant-500B
rs363287 -- 117,280,632(+) GGAGT(A/G)TTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDZD8 Gene

Variant ID Type Subtype PubMed ID
nsv7564 CNV Insertion 18451855
esv2659578 CNV Deletion 23128226
nsv825578 CNV Loss 20364138
esv1007152 CNV Deletion 20482838

Variation tolerance for PDZD8 Gene

Residual Variation Intolerance Score: 7.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDZD8 Gene

HapMap Linkage Disequilibrium report
PDZD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDZD8 Gene

Disorders for PDZD8 Gene

Relevant External Links for PDZD8

Genetic Association Database (GAD)
PDZD8
Human Genome Epidemiology (HuGE) Navigator
PDZD8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDZD8

No disorders were found for PDZD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDZD8 Gene

Publications for PDZD8 Gene

  1. PDZD8 is a novel Gag-interacting factor that promotes retroviral infection. (PMID: 20573829) Henning M.S. … Naghavi M.H. (J. Virol. 2010) 2 3 4 67
  2. Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8. (PMID: 25771112) Zhang S. … Sodroski J. (Virology 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Contribution of PDZD8 to stabilization of the human immunodeficiency virus type 1 capsid. (PMID: 24554657) Guth C.A. … Sodroski J. (J. Virol. 2014) 3
  5. Roles of HIV-1 capsid in viral replication and immune evasion. (PMID: 25036886) Le Sage V. … Valiente-EcheverrA-a F. (Virus Res. 2014) 3

Products for PDZD8 Gene

Sources for PDZD8 Gene

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