PDZD8 Gene
protein-coding GIFtS: 46
GCID: GC10M119033
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PDZ domain containing 8
(Previous symbol: PDZK8)
| |
Aliases
for PDZD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PDZ Domain Containing 81 2 | | FLJ344271 | | PDZK81 2 3 | | PDZ Domain-Containing Protein 82 | | BA129M16.21 | | Sarcoma Antigen NY-SAR-1042 | | Sarcoma Antigen NY-SAR-84/NY-SAR-1042 3 | | Sarcoma Antigen NY-SAR-842 |
Export aliases for PDZD8 gene to outside databasesPrevious GC identifer: GC10M112670 |
Summaries
for PDZD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PDZD8_HUMAN, Q8NEN9Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplexvirus 1 infection at an early stage. May promote retroviral infection
|
Genomic Views
for PDZD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDZD8 gene promoter:
Pax-5 ATF-2 NCX/Ncx MyoD Egr-2 PPAR-gamma1 NRF-2 PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDZD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDZD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.12 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.12PDZD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M119033: view genomic region
(about GC identifiers)
Start:
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119,040,000 bp from pter |
End:
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119,134,978 bp from pter |
Size:
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94,979 bases |
Orientation:
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minus strand |
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Proteins
for PDZD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDZD8_HUMAN, Q8NEN9 (See
protein sequence)Recommended Name: PDZ domain-containing protein 8 Size: 1154 amino acids; 128563 Da
Subunit: Interacts with MSN. Interacts with HIV-1 Gag polyprotein p55
Sequence caution: Sequence=AAO65182.1; Type=Frameshift; Positions=421;
Secondary accessions: Q86WE0 Q86WE5 Q9UFF1Explore the universe of human proteins at neXtProt for PDZD8: NX_Q8NEN9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEN9
PDZD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776152.1
ENSEMBL proteins: ENSP00000334642
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
PDZD8 for ontologies About GeneDecksing
PDZD8 Antibody Products:
Assay Products for PDZD8: |
Protein
Domains /
Families
for PDZD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDZD8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NEN9ProtoNet protein and cluster: Q8NEN9 1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain
UniProtKB/Swiss-Prot: PDZD8_HUMAN, Q8NEN9Similarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc finger |
Function
for PDZD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PDZD8_HUMAN, Q8NEN9Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplexvirus 1 infection at an early stage. May promote retroviral infection
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDZD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDZD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PDZD8 (NM_173791) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDZD8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZD8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZD8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
PDZD8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PDZD8:
|
Pathways & Interactions
for PDZD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDZD8
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for PDZD8 (ENSP000003346424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007010 | cytoskeleton organization |
IMP | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0022604 | regulation of cell morphogenesis |
IMP | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
PDZD8 for ontologies About GeneDecksing
|
Drugs & Compounds
for PDZD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PDZD8
10/843 HMDB Compounds for PDZD8 (see all 843) About this table
Search CenterWatch for drugs/clinical trials and news about PDZD8
|
Transcripts
for PDZD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDZD8 gene: NM_173791.3 Unigene Cluster for PDZD8: PDZ domain containing 8 Hs.501149 [show with all ESTs]Unigene Representative Sequence: BC0283754 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334464(uc001lde.1) ENST00000482496 ENST00000489302 ENST00000489491
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDZD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDZD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PDZD8 (NM_173791) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDZD8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZD8 |
Additional cDNA sequence: AF086138.1 AK058141.1 AK091746.1 AL122051.1 AY211924.1 AY211929.1 BC012186.1 BC028375.1 BC033019.1 7 DOTS entries: DT.452019 DT.91693592 DT.100785495 DT.99986412 DT.91884249 DT.95190976 DT.121261185 24/106 AceView cDNA sequences (see all 106): AW351708 BM712766 CA841687 BC028375 H18764 CA388828 BC012186 CD300603 BX486824 AL601521 BF194807 BM312160 AW468420 AI052247 BX350374 AI028307 R20185 AW470846 BX507311 BQ045436 AA923688 BE781393 AK091746 BE872180
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PDZD8 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|
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| SP1: | | | | | | | - | | - | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for PDZD8
|
Expression
for PDZD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDZD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTTACTAA
About this image
See PDZD8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDZD8
SOURCE GeneReport for Unigene cluster: Hs.501149
SABiosciences Custom PCR Arrays for PDZD8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDZD8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDZD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDZD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDZD8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZD8 |
Orthologs
for PDZD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PDZD8 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for PDZD8 (if available)
TreeFam Gene Tree for PDZD8 (if available) |
Paralogs
for PDZD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PDZD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDZD8 (119040000 - 119134978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDZD8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDZD8 |
|
Disorders
/ Diseases
for PDZD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDZD8 for disorders About GeneDecksing
OMIM gene information: 614235
OMIM disorders: --
3  diseases for PDZD8: About MalaCardssarcoma herpes simplex alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: PDZD8 (1 document)
Export disorders for PDZD8 gene to outside databases
|
Publications
for PDZD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDZD8 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with PDZD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1. (PubMed id 21549406)1, 2 Henning M.S.... Naghavi M.H. (2011)
- PDZD8 is a novel Gag-interacting factor that promotes retroviral infection. (PubMed id 20573829)1, 2 Henning M.S....Naghavi M.H. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern. (PubMed id 22683750)1 Sinner M.F....Salomaa V. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for PDZD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PDZD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PDZD8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDZD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PDZD8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PDZD8 gene:
Search GeneIP for patents involving PDZD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PDZD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PDZD8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDZD8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDZD8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDZD8 | | OriGene 3'-UTR Clone for PDZD8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDZD8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDZD8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PDZD8 | | OriGene Custom Protein Services for PDZD8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDZD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDZD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDZD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDZD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDZD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDZD8 |
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| | | | Search Tocris compounds for PDZD8 |
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 | | | PDZD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZD8 |
|  |  |  | | | | Search ThermoFisher Antibodies for PDZD8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZD8 |
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