Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PDZD3 Gene

protein-coding   GIFtS: 50
GCID: GC11P119056

PDZ Domain Containing 3

(Previous name: PDZ domain containing 2)
(Previous symbol: PDZK2)
  See PDZD3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
PDZ Domain Containing 31 2     NHERF-42 3
PDZK21 2 3     NHERF42 3
IKEPP2 3 5     PDZ Domain-Containing Protein 22 3
PDZ Domain Containing 21 2     PDZ Domain-Containing Protein 32 3
Intestinal And Kidney-Enriched PDZ Protein2 3     Intestinal And Kidney Enriched PDZ Protein2
Na/Pi Cotransporter C-Terminal-Associated Protein 22 3     Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF42
Natrium-Phosphate Cotransporter IIa C-Terminal-Associated Protein 22 3     naPi-Cap22
Sodium-Hydrogen Exchanger Regulatory Factor 42 3     NaPi-Cap23

External Ids:    HGNC: 198911   Entrez Gene: 798492   Ensembl: ENSG000001723677   OMIM: 6071465   UniProtKB: Q86UT53   
ORGUL members:         

Export aliases for PDZD3 gene to outside databases

Previous GC identifers: GC11P118559 GC11P114995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PDZD3 Gene:
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands
or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a
signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR;
MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein
that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al.,
2002 (PubMed 11950846)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PDZD3 Gene:
PDZD3 (PDZ domain containing 3) is a protein-coding gene. Diseases associated with PDZD3 include secretory diarrhea, and cystic fibrosis. GO annotations related to this gene include guanylate cyclase inhibitor activity and protein C-terminus binding. An important paralog of this gene is SLC9A3R2.

UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5
Function: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable
enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDZD3 gene promoter:
         Elk-1   ATF-2   STAT5A   AP-2gamma   c-Ets-1   STAT3   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDZD3 promoter sequence
   Search Chromatin IP Primers for PDZD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDZD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

PDZD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDZD3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119056:  view genomic region     (about GC identifiers)

Start:
119,056,166 bp from pter      End:
119,060,932 bp from pter
Size:
4,767 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5 (See protein sequence)
Recommended Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4  
Size: 571 amino acids; 61032 Da
Subunit: Interacts with the C-terminal region of GUCY2C. Interacts with the C-terminal region of SLC34A1.
Interacts with the C-terminal region SLC9A3 and the interactions decrease in response to elevated calcium ion
levels
1 PDB 3D structure from and Proteopedia for PDZD3:
2V90 (3D)    
Secondary accessions: Q8N6R4 Q8NAW7 Q8NEX7 Q9H5Z3
Alternative splicing: 5 isoforms:  Q86UT5-1   Q86UT5-2   Q86UT5-3   Q86UT5-4   Q86UT5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDZD3: NX_Q86UT5

Explore proteomics data for PDZD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PDZD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161940.1  NP_079067.3  

    ENSEMBL proteins: 
     ENSP00000434559   ENSP00000431164   ENSP00000434264   ENSP00000347742   ENSP00000327107  
     ENSP00000376564  

    PDZD3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PDZD3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PDZD3
    GenScript Custom Purified and Recombinant Proteins Services for PDZD3
    Novus Biologicals PDZD3 Protein
    Novus Biologicals PDZD3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDZD3

     
    Search eBioscience for Proteins for PDZD3 

     
    antibodies-online proteins for PDZD3 (4 products) 

     
    antibodies-online peptides for PDZD3

    PDZD3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PDZD3
    OriGene Custom Antibody Services for PDZD3
    Novus Biologicals PDZD3 Antibodies
    Abcam antibodies for PDZD3
    Cloud-Clone Corp. Antibodies for PDZD3
    ThermoFisher Antibodies for PDZD3
    LSBio Antibodies in human, mouse, rat for PDZD3
    antibodies-online antibodies for PDZD3 (28 products) 

    PDZD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDZD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDZD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDZD3
    Cloud-Clone Corp. CLIAs for PDZD3
    Search eBioscience for ELISAs for PDZD3 
    antibodies-online kits for PDZD3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q86UT5

    ProtoNet protein and cluster: Q86UT5

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5
    Similarity: Contains 4 PDZ (DHR) domains


    Find genes that share domains with PDZD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NHRF4_HUMAN, Q86UT5
    Function: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable
    enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11950846
    GO:0008022protein C-terminus binding IPI11950846
    GO:0008200ion channel inhibitor activity TAS11950846
    GO:0030251guanylate cyclase inhibitor activity IDA11950846
         
    Find genes that share ontologies with PDZD3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDZD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDZD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDZD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDZD3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PDZD3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PDZD3:
    hsa-miR-515-5p hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidPDZD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDZD3
    Predesigned siRNA for gene silencing in human, mouse, rat PDZD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDZD3

    Clone
    Products:
         
    OriGene clones in human, mouse for PDZD3 (see all 11)
    OriGene ORF clones in mouse, rat for PDZD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDZD3 (NM_024791)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDZD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZD3
    Addgene plasmids for PDZD3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDZD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDZD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NHRF4_HUMAN, Q86UT5: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at
    the apical surface and ileal brush border of intestinal epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS11950846
    GO:0005903brush border IDA19088451
    GO:0035003subapical complex IDA11950846
    GO:0045177apical part of cell IDA11950846

    Find genes that share ontologies with PDZD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDZD3
    Interactions:

        Search GeneGlobe Interaction Network for PDZD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for PDZD3 (Q86UT51, 2, 3 ENSP000003271074) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GUCY2CP250921, 2, 3, ENSP000002611704EBI-8299496,EBI-2816795 MINT-1773222 MINT-1777648 MINT-1777755 MINT-1777668 I2D: score=1 STRING: ENSP00000261170
    SLC34A1Q064953, ENSP000003214244I2D: score=2 STRING: ENSP00000321424
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    ABCC2Q928873, ENSP000003594784I2D: score=1 STRING: ENSP00000359478
    SLC17A1Q149163, ENSP000002445274I2D: score=2 STRING: ENSP00000244527
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport NAS11950846
    GO:0006833water transport NAS11950846
    GO:0007168receptor guanylyl cyclase signaling pathway IC11950846
    GO:0009636response to toxic substance TAS11950846
    GO:0019934cGMP-mediated signaling NAS11950846

    Find genes that share ontologies with PDZD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDZD3 (NHRF4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PDZD3 gene (2 alternative transcripts): 
    NM_001168468.1  NM_024791.3  

    Unigene Cluster for PDZD3:

    PDZ domain containing 3
    Hs.374726  [show with all ESTs]
    Unigene Representative Sequence: NR_033122
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527308 ENST00000526279 ENST00000527951 ENST00000525131 ENST00000534790
    ENST00000529098 ENST00000527028(uc001pwa.3) ENST00000531114(uc001pvz.3 uc010rzd.2 uc001pvy.3 uc001pwb.3)
    ENST00000533688 ENST00000355547 ENST00000526836 ENST00000528730 ENST00000322712
    ENST00000529573 ENST00000392817
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDZD3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PDZD3:
    hsa-miR-515-5p hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidPDZD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDZD3
    Predesigned siRNA for gene silencing in human, mouse, rat PDZD3
    Clone
    Products:
         
    OriGene clones in human, mouse for PDZD3 (see all 11)
    OriGene ORF clones in mouse, rat for PDZD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDZD3 (NM_024791)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDZD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZD3
    Addgene plasmids for PDZD3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDZD3
    OriGene qSTAR qPCR primer pairs in human, mouse for PDZD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDZD3
      QuantiTect SYBR Green Assays in human, mouse, rat PDZD3
      QuantiFast Probe-based Assays in human, mouse, rat PDZD3

    Additional mRNA sequence: 

    AK298333.1 AK315403.1 AY047359.1 BC029042.1 NR_033122.1 

    9 DOTS entries:

    DT.95155211  DT.100697248  DT.100748470  DT.436893  DT.100019795  DT.120679452  DT.120679454  DT.97836612 
    DT.101975666 

    Selected AceView cDNA sequences (see all 27):

    AI694273 AB094096 AI640747 AI671486 AI498682 BM772915 NM_024791 AX747282 
    BC029042 AK091966 AY047359 BI764343 BX479666 AA088694 AA047168 AK026409 
    BM756078 BX648391 AA910232 AA088831 AA047169 BP382917 AA534370 BF509862 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDZD3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -                       -                                   -                                                   
    SP2:                                                  -                             -     -                                                   
    SP3:                                                                                      -                                                   
    SP4:                                                  -                                   -                                                   
    SP5:                                                  -                                                                                       


    ECgene alternative splicing isoforms for PDZD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PDZD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCGCCTGT
    PDZD3 Expression
    About this image

    PDZD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDZD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374726

    UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5
    Tissue specificity: Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal
    muscle or cells of hematopoietic origin

        Custom PCR Arrays for PDZD3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDZD3
    OriGene qSTAR qPCR primer pairs in human, mouse for PDZD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDZD3
    QuantiTect SYBR Green Assays in human, mouse, rat PDZD3
    QuantiFast Probe-based Assays in human, mouse, rat PDZD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PDZD3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdzd31 , 5 PDZ domain containing 31, 5 82.8(n)1
    82.13(a)1
      9 (24.84 cM)5
    1707611  NM_133226.21  NP_573489.21 
     442473125 
    chicken
    (Gallus gallus)
    Aves PDZD31 PDZ domain containing 3 59.06(n)
    50.66(a)
      769876  XM_001233190.3  XP_001233191.3 
    lizard
    (Anolis carolinensis)
    Reptilia PDZD36
    PDZ domain containing 3
    49(a)
    1 ↔ 1
    GL343722.1(12444-25079)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pdzd31 PDZ domain containing 3 54.72(n)
    49.58(a)
      100489736  XM_002935017.2  XP_002935063.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pdzd3a1 PDZ domain containing 3a 50.72(n)
    40.32(a)
      557269  XM_680306.4  XP_685398.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sip16
    SRY interacting protein 1
    23(a)
    1 → many
    2R(13282101-13292678)


    ENSEMBL Gene Tree for PDZD3 (if available)
    TreeFam Gene Tree for PDZD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PDZD3 gene
    SLC9A3R22  SLC9A3R12  PDZK12  
    5 SIMAP similar genes for PDZD3 using alignment to 4 protein entries:     NHRF4_HUMAN (see all proteins):
    SLC9A3R1    PDZK1P1    PDZK1P2    PDZK1    SLC9A3R2

    Find genes that share paralogs with PDZD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PDZD3 (see all 185)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021118771,2
    --119055249(+) CTGTC-/AAAAAA 3 -- us2k10--------
    rs79297991,2
    C,F,A--119055362(+) tacatA/Ggcagc 3 -- us2k16Minor allele frequency- G:0.36NA NS WA 162
    rs1176178871,2
    C,F--119055386(+) TGTGCC/TGGGGA 3 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1171465331,2
    F--119055460(+) AAAACC/TTGCCC 3 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1465184981,2
    --119055555(+) GGACAA/CAGCCA 3 -- us2k10--------
    rs1178702581,2
    F--119055668(+) GGGTCA/GGATTC 3 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1404820631,2
    C--119055722(+) GAACCC/TACACA 3 -- us2k10--------
    rs112171721,2
    C,H--119055748(+) AGACTC/TTCagc 3 -- us2k16Minor allele frequency- T:0.00NS EA NA 424
    rs1442107301,2
    C--119055768(+) TGGCTC/GACGCC 3 -- us2k10--------
    rs1879672551,2
    --119055896(+) GTGTGA/GTGGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDZD3 (119056166 - 119060932 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PDZD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468879CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDZD3
    DNA2.0 Custom Variant and Variant Library Synthesis for PDZD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607146    OMIM disorders: --

    2 diseases for PDZD3:    
    About MalaCards
    secretory diarrhea    cystic fibrosis

    1 disease from the University of Copenhagen DISEASES database for PDZD3:
    Secretory diarrhea

    Find genes that share disorders with PDZD3           About GenesLikeMe


    Export disorders for PDZD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PDZD3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with PDZD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. (PubMed id 11950846)1, 2, 3 Scott R.O.... Milgram S.L. (J. Biol. Chem. 2002)
    2. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism. (PubMed id 19088451)1, 2 Zachos N.C.... Donowitz M. (Cell. Physiol. Biochem. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction. (PubMed id 22627094)1 Lee J.H....Yoon J.S. (Cell. Signal. 2012)
    6. Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP). (PubMed id 22884631)1 Reid H.M....Kinsella B.T. (Biochim. Biophys. Acta 2012)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    9. PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. (PubMed id 15523054)1 Kato Y....Tsuji A. (Mol. Pharmacol. 2005)
    10. Screening of the interaction between xenobiotic transporters and PDZ proteins. (PubMed id 15553237)1 Kato Y....Tsuji A. (Pharm. Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79849 HGNC: 19891 AceView: PDZK2 Ensembl:ENSG00000172367 euGenes: HUgn79849
    ECgene: PDZD3 H-InvDB: PDZD3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PDZD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PDZD3 gene:
    Search GeneIP for patents involving PDZD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PDZD3   OriGene RNAi products in human, mouse, rat for PDZD3  
     OriGene qPCR primer pairs and template standards for PDZD3   OriGene Protein Over-expression Lysate for PDZD3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PDZD3  
     OriGene qSTAR qPCR primer pairs in human, mouse for PDZD3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PDZD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDZD3   OriGene Custom Protein Services for PDZD3  

     
     
     Block miRNA regulation of human, mouse, rat PDZD3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PDZD3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDZD3 Predesigned siRNA for gene silencing in human, mouse, rat PDZD3
     QuantiFast Probe-based Assays in human, mouse, rat PDZD3 QuantiTect SYBR Green Assays in human, mouse, rat PDZD3
     Custom PCR Arrays for PDZD3 Search Chromatin IP Primers for PDZD3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDZD3  Search GeneGlobe Interaction Network for PDZD3
     Regulatory tfbs in PDZD3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PDZD3 GenScript cDNA clones with any tag delivered in your preferred vector for PDZD3
     GenScript Custom Assay Services for PDZD3 GenScript Custom overexpressing Cell Line Services for PDZD3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PDZD3 (NHRF4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PDZD3 antibodies
     PDZD3 proteins
     PDZD3 lysates
     Antibodies for PDZD3
     See all of Abcam's Antibodies, Kits and Proteins for PDZD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PDZD3
     Antibodies for PDZD3
     ELISAs for PDZD3
     CLIAs for PDZD3



     Browse ESI BIO Cell Lines and PureStem Progenitors for PDZD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDZD3
     SwitchGear 3'UTR luciferase reporter plasmids for PDZD3
     SwitchGear Promoter luciferase reporter plasmids for PDZD3
     ThermoFisher Antibodies for PDZD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDZD3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDZD3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDZD3
     LSBio Antibodies in human, mouse, rat for PDZD3
     Browse compounds at ApexBio
     Addgene plasmids for PDZD3
      Search eBioscience for proteins for PDZD3
      Search eBioscience for elisas for PDZD3
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for PDZD3 (28 products)
     antibodies-online kits for PDZD3 (4 products)
     antibodies-online peptides for PDZD3
     antibodies-online proteins for PDZD3 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PDZD3 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4