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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDZD3 Gene

protein-coding   GIFtS: 50
GCID: GC11P119056

PDZ Domain Containing 3

(Previous name: PDZ domain containing 2)
(Previous symbol: PDZK2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
PDZ Domain Containing 31 2     NHERF-42 3
PDZK21 2 3     NHERF42 3
IKEPP2 3 5     PDZ Domain-Containing Protein 22 3
PDZ Domain Containing 21 2     PDZ Domain-Containing Protein 32 3
Intestinal And Kidney-Enriched PDZ Protein2 3     Intestinal And Kidney Enriched PDZ Protein2
Na/Pi Cotransporter C-Terminal-Associated Protein 22 3     Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF42
Natrium-Phosphate Cotransporter IIa C-Terminal-Associated Protein 22 3     naPi-Cap22
Sodium-Hydrogen Exchanger Regulatory Factor 42 3     NaPi-Cap23

External Ids:    HGNC: 198911   Entrez Gene: 798492   Ensembl: ENSG000001723677   OMIM: 6071465   UniProtKB: Q86UT53   
ORGUL members:         
NONCODE14:n409063      

Export aliases for PDZD3 gene to outside databases

Previous GC identifers: GC11P118559 GC11P114995


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDZD3 Gene:
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands
or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a
signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR;
MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein
that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al.,
2002 (PubMed 11950846)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PDZD3 Gene: 
PDZD3 (PDZ domain containing 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PDZD3 include dysentery, and secretory diarrhea. GO annotations related to this gene include guanylate cyclase inhibitor activity and protein C-terminus binding. An important paralog of this gene is SLC9A3R2.

UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5
Function: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable
enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDZD3 gene promoter:
         Elk-1   ATF-2   STAT5A   AP-2gamma   c-Ets-1   STAT3   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDZD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDZD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDZD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

PDZD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDZD3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119056:  view genomic region     (about GC identifiers)

Start:
119,056,166 bp from pter      End:
119,060,932 bp from pter
Size:
4,767 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5 (See protein sequence)
Recommended Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF4  
Size: 571 amino acids; 61032 Da
Subunit: Interacts with the C-terminal region of GUCY2C. Interacts with the C-terminal region of SLC34A1.
Interacts with the C-terminal region SLC9A3 and the interactions decrease in response to elevated calcium ion
levels
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at
the apical surface and ileal brush border of intestinal epithelial cells
1 PDB 3D structure from and Proteopedia for PDZD3:
2V90 (3D)    
Secondary accessions: Q8N6R4 Q8NAW7 Q8NEX7 Q9H5Z3
Alternative splicing: 5 isoforms:  Q86UT5-1   Q86UT5-2   Q86UT5-3   Q86UT5-4   Q86UT5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDZD3: NX_Q86UT5

Explore proteomics data for PDZD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UT5

  • PDZD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDZD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001161940.1  NP_079067.3  

    ENSEMBL proteins: 
     ENSP00000434559   ENSP00000431164   ENSP00000434264   ENSP00000347742   ENSP00000327107  
     ENSP00000376564  

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    Cloud-Clone Corp. Proteins for PDZD3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS11950846
    GO:0005903brush border IDA19088451
    GO:0035003subapical complex IDA11950846
    GO:0045177apical part of cell IDA11950846

    PDZD3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q86UT5

    ProtoNet protein and cluster: Q86UT5

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5
    Similarity: Contains 4 PDZ (DHR) domains


    PDZD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NHRF4_HUMAN, Q86UT5
    Function: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable
    enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11950846
    GO:0008022protein C-terminus binding IPI11950846
    GO:0008200ion channel inhibitor activity TAS11950846
    GO:0030251guanylate cyclase inhibitor activity IDA11950846
         
    PDZD3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDZD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for PDZD3 (Q86UT52, 3 ENSP000003271074) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GUCY2CP250922, 3, ENSP000002611704MINT-1773222 MINT-1777648 MINT-1777755 MINT-1777668 I2D: score=1 STRING: ENSP00000261170
    SLC34A1Q064953, ENSP000003214244I2D: score=2 STRING: ENSP00000321424
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    ABCC2Q928873, ENSP000003594784I2D: score=1 STRING: ENSP00000359478
    SLC17A1Q149163I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport NAS11950846
    GO:0006833water transport NAS11950846
    GO:0007168receptor guanylyl cyclase signaling pathway IC11950846
    GO:0009636response to toxic substance TAS11950846
    GO:0019934cGMP-mediated signaling NAS11950846

    PDZD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDZD3 (NHRF4)

    Search CenterWatch for drugs/clinical trials and news about PDZD3 / NHRF4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDZD3 gene (2 alternative transcripts): 
    NM_001168468.1  NM_024791.3  

    Unigene Cluster for PDZD3:

    PDZ domain containing 3
    Hs.374726  [show with all ESTs]
    Unigene Representative Sequence: NR_033122
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527308 ENST00000526279 ENST00000527951 ENST00000525131 ENST00000534790
    ENST00000529098 ENST00000527028(uc001pwa.3) ENST00000531114(uc001pvz.3 uc010rzd.2 uc001pvy.3 uc001pwb.3)
    ENST00000533688 ENST00000355547 ENST00000526836 ENST00000528730 ENST00000322712
    ENST00000529573 ENST00000392817
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-515-5p hsa-miR-519e*
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    Additional mRNA sequence: 

    AK298333.1 AK315403.1 AY047359.1 BC029042.1 NR_033122.1 

    9 DOTS entries:

    DT.95155211  DT.100697248  DT.100748470  DT.436893  DT.100019795  DT.120679452  DT.120679454  DT.97836612 
    DT.101975666 

    24/27 AceView cDNA sequences (see all 27):

    AX747282 BC029042 AI640747 NM_024791 AI694273 AI498682 AB094096 AI671486 
    AK091966 AY047359 BM772915 BM756078 AA910232 AA047168 AA088694 BX479666 
    BI764343 AK026409 BX648391 AA534370 BP382917 AA088831 BF509862 AA047169 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PDZD3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -                       -                                   -                                                   
    SP2:                                                  -                             -     -                                                   
    SP3:                                                                                      -                                                   
    SP4:                                                  -                                   -                                                   
    SP5:                                                  -                                                                                       


    ECgene alternative splicing isoforms for PDZD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDZD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCGCCTGT
    PDZD3 Expression
    About this image


    See PDZD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDZD3

    SOURCE GeneReport for Unigene cluster: Hs.374726

    UniProtKB/Swiss-Prot: NHRF4_HUMAN, Q86UT5
    Tissue specificity: Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal
    muscle or cells of hematopoietic origin

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDZD3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdzd31 , 5 PDZ domain containing 31, 5 82.8(n)1
    82.13(a)1
      9 (24.84 cM)5
    1707611  NM_133226.21  NP_573489.21 
     442473125 
    chicken
    (Gallus gallus)
    Aves PDZD31 PDZ domain containing 3 59.47(n)
    52(a)
      769876  XM_001233190.2  XP_001233191.2 
    lizard
    (Anolis carolinensis)
    Reptilia PDZD36
    PDZ domain containing 3
    48(a)
    1 ↔ 1
    GL343722.1(12444-25079)
    zebrafish
    (Danio rerio)
    Actinopterygii pdzd3a6
    pdzd3b6
    PDZ domain containing 3b
    34(a)
    31(a)
    1 ↔ many
    1 ↔ many
    15(22806410-22821298)
    5(32319821-32336629)
    fruit fly
    (Drosophila melanogaster)
    Insecta Sip16
    SRY interacting protein 1
    21(a)
    1 → many
    2R(13282101-13292678)


    ENSEMBL Gene Tree for PDZD3 (if available)
    TreeFam Gene Tree for PDZD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDZD3 gene
    SLC9A3R22  SLC9A3R12  PDZK12  
    5 SIMAP similar genes for PDZD3 using alignment to 4 protein entries:     NHRF4_HUMAN (see all proteins):
    SLC9A3R1    PDZK1P1    PDZK1P2    PDZK1    SLC9A3R2

    PDZD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 SNPs in PDZD3 are shown (see all 185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021118771,2
    --119055249(+) CTGTC-/AAAAAA 3 -- us2k10--------
    rs79297991,2
    C,F,A--119055362(+) tacatA/Ggcagc 3 -- us2k16Minor allele frequency- G:0.36NA NS WA 162
    rs1176178871,2
    C,F--119055386(+) TGTGCC/TGGGGA 3 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1171465331,2
    F--119055460(+) AAAACC/TTGCCC 3 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1465184981,2
    --119055555(+) GGACAA/CAGCCA 3 -- us2k10--------
    rs1178702581,2
    F--119055668(+) GGGTCA/GGATTC 3 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1404820631,2
    C--119055722(+) GAACCC/TACACA 3 -- us2k10--------
    rs112171721,2
    C,H--119055748(+) AGACTC/TTCagc 3 -- us2k16Minor allele frequency- T:0.00NS EA NA 424
    rs1442107301,2
    C--119055768(+) TGGCTC/GACGCC 3 -- us2k10--------
    rs1879672551,2
    --119055896(+) GTGTGA/GTGGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDZD3 (119056166 - 119060932 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PDZD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv468879CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607146    OMIM disorders: --

    4 diseases for PDZD3:    About MalaCards
    dysentery    secretory diarrhea    diarrhea    cystic fibrosis

    1 disease from the University of Copenhagen DISEASES database for PDZD3:
    Secretory diarrhea

    PDZD3 for disorders           About GeneDecksing


    Export disorders for PDZD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDZD3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with PDZD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. (PubMed id 11950846)1, 2, 3 Scott R.O.... Milgram S.L. (2002)
    2. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism. (PubMed id 19088451)1, 2 Zachos N.C.... Donowitz M. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP). (PubMed id 22884631)1 Reid H.M....Kinsella B.T. (2012)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    8. PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. (PubMed id 15523054)1 Kato Y....Tsuji A. (2005)
    9. Screening of the interaction between xenobiotic trans porters and PDZ proteins. (PubMed id 15553237)1 Kato Y....Tsuji A. (2004)
    10. C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. (PubMed id 12615054)1 Hegedus T....Sarkadi B. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79849 HGNC: 19891 AceView: PDZK2 Ensembl:ENSG00000172367 euGenes: HUgn79849
    ECgene: PDZD3 H-InvDB: PDZD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDZD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDZD3 gene:
    Search GeneIP for patents involving PDZD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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