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Aliases for PDZD11 Gene

Aliases for PDZD11 Gene

  • PDZ Domain Containing 11 2 3
  • Plasma Membrane Calcium ATPase-Interacting Single-PDZ Protein 3 4
  • PMCA-Interacting Single-PDZ Protein 3 4
  • ATPase-Interacting PDZ Protein 3 4
  • PDZK11 3 4
  • AIPP1 3 4
  • PISP 3 4

External Ids for PDZD11 Gene

Previous HGNC Symbols for PDZD11 Gene

  • PDZK11

Previous GeneCards Identifiers for PDZD11 Gene

  • GC0XM069289
  • GC0XM068822
  • GC0XM069422
  • GC0XM069506
  • GC0XM063327

Summaries for PDZD11 Gene

GeneCards Summary for PDZD11 Gene

PDZD11 (PDZ Domain Containing 11) is a Protein Coding gene. Diseases associated with PDZD11 include purulent acute otitis media and pleomorphic adenoma carcinoma. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is LIN7A.

Gene Wiki entry for PDZD11 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDZD11 Gene

Genomics for PDZD11 Gene

Regulatory Elements for PDZD11 Gene

Genomic Location for PDZD11 Gene

Chromosome:
X
Start:
70,286,361 bp from pter
End:
70,290,514 bp from pter
Size:
4,154 bases
Orientation:
Minus strand

Genomic View for PDZD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDZD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDZD11 Gene

Proteins for PDZD11 Gene

  • Protein details for PDZD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBL8-PDZ11_HUMAN
    Recommended name:
    PDZ domain-containing protein 11
    Protein Accession:
    Q5EBL8
    Secondary Accessions:
    • D3DVU3
    • Q6UWE1
    • Q9P0Q1

    Protein attributes for PDZD11 Gene

    Size:
    140 amino acids
    Molecular mass:
    16131 Da
    Quaternary structure:
    • Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A.

    Alternative splice isoforms for PDZD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDZD11 Gene

Proteomics data for PDZD11 Gene at MOPED

Post-translational modifications for PDZD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDZD11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PDZD11 Gene

Domains & Families for PDZD11 Gene

Protein Domains for PDZD11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDZD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EBL8

UniProtKB/Swiss-Prot:

PDZ11_HUMAN :
  • Contains 1 PDZ (DHR) domain.
Domain:
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with PDZD11: view

No data available for Gene Families for PDZD11 Gene

Function for PDZD11 Gene

Gene Ontology (GO) - Molecular Function for PDZD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12763866
GO:0008022 protein C-terminus binding IPI 12763866
genes like me logo Genes that share ontologies with PDZD11: view
genes like me logo Genes that share phenotypes with PDZD11: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDZD11

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PDZD11 Gene

Localization for PDZD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDZD11 Gene

Isoform 2: Secreted.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDZD11 Gene COMPARTMENTS Subcellular localization image for PDZD11 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for PDZD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IBA --
GO:0016323 basolateral plasma membrane IDA 12763866
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with PDZD11: view

Pathways & Interactions for PDZD11 Gene

genes like me logo Genes that share pathways with PDZD11: view

Gene Ontology (GO) - Biological Process for PDZD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006768 biotin metabolic process TAS --
GO:0006887 exocytosis IBA --
GO:0007269 neurotransmitter secretion IBA --
genes like me logo Genes that share ontologies with PDZD11: view

No data available for SIGNOR curated interactions for PDZD11 Gene

Drugs & Compounds for PDZD11 Gene

No Compound Related Data Available

Transcripts for PDZD11 Gene

Unigene Clusters for PDZD11 Gene

PDZ domain containing 11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDZD11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDZD11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - -
SP2:
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - -

Relevant External Links for PDZD11 Gene

GeneLoc Exon Structure for
PDZD11
ECgene alternative splicing isoforms for
PDZD11

Expression for PDZD11 Gene

mRNA expression in normal human tissues for PDZD11 Gene

Protein differential expression in normal tissues from HIPED for PDZD11 Gene

This gene is overexpressed in Salivary gland (11.4) and Stomach (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDZD11 Gene



SOURCE GeneReport for Unigene cluster for PDZD11 Gene Hs.11042

mRNA Expression by UniProt/SwissProt for PDZD11 Gene

Q5EBL8-PDZ11_HUMAN
Tissue specificity: Widely expressed (at protein level).
genes like me logo Genes that share expression patterns with PDZD11: view

Protein tissue co-expression partners for PDZD11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PDZD11 Gene

Orthologs for PDZD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDZD11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDZD11 35
  • 94.76 (n)
  • 97.86 (a)
PDZD11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDZD11 35
  • 94.05 (n)
  • 97.86 (a)
PDZD11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdzd11 35
  • 92.62 (n)
  • 97.14 (a)
Pdzd11 16
Pdzd11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDZD11 35
  • 99.52 (n)
  • 100 (a)
PDZD11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdzd11 35
  • 93.33 (n)
  • 97.14 (a)
oppossum
(Monodelphis domestica)
Mammalia PDZD11 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDZD11 35
  • 81.54 (n)
  • 89.23 (a)
PDZD11 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDZD11 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdzd11 35
  • 77.62 (n)
  • 87.14 (a)
Str.2023 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19447 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15270 35
pdzd11 35
  • 73.57 (n)
  • 89.29 (a)
pdzd11 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta veli 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-7 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for PDZD11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDZD11 Gene

ENSEMBL:
Gene Tree for PDZD11 (if available)
TreeFam:
Gene Tree for PDZD11 (if available)

Paralogs for PDZD11 Gene

Paralogs for PDZD11 Gene

(8) SIMAP similar genes for PDZD11 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PDZD11 Gene

genes like me logo Genes that share paralogs with PDZD11: view

Variants for PDZD11 Gene

Sequence variations from dbSNP and Humsavar for PDZD11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14492 -- 70,286,794(+) ATGTA(A/T)GGGAC utr-variant-3-prime
rs11546429 -- 70,286,913(-) CCTAG(C/T)TTTCT utr-variant-3-prime
rs11546430 -- 70,287,331(-) GCTGT(C/T)GAGAT synonymous-codon, reference
rs112772097 -- 70,287,993(+) GGGTG(C/T)CTCCA intron-variant
rs113177976 -- 70,286,452(+) CTAAT(A/G)TTCTG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PDZD11 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Variation tolerance for PDZD11 Gene

Residual Variation Intolerance Score: 51.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDZD11 Gene

HapMap Linkage Disequilibrium report
PDZD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDZD11 Gene

Disorders for PDZD11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDZD11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
purulent acute otitis media
  • acute suppurative otitis media
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
middle ear disease
  • middle ear disorder
- elite association

Relevant External Links for PDZD11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDZD11
genes like me logo Genes that share disorders with PDZD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDZD11 Gene

Publications for PDZD11 Gene

  1. A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis. (PMID: 16051599) Stephenson S.E. … La Fontaine S. (J. Biol. Chem. 2005) 23 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for PDZD11 Gene

Sources for PDZD11 Gene

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