Aliases for PDYN Gene
External Ids for PDYN Gene
Previous HGNC Symbols for PDYN Gene
Previous GeneCards Identifiers for PDYN Gene
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for PDYN Gene
PDYN (Prodynorphin) is a Protein Coding gene. Diseases associated with PDYN include Spinocerebellar Ataxia 23 and Spinocerebellar Ataxia Type23. Among its related pathways are Peptide ligand-binding receptors and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include opioid peptide activity. An important paralog of this gene is PENK.
UniProtKB/Swiss-Prot for PDYN Gene
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.