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Aliases for PDYN Gene

Aliases for PDYN Gene

  • Prodynorphin 2 3
  • Neoendorphin-Dynorphin-Enkephalin Prepropeptide 2 3
  • Beta-Neoendorphin-Dynorphin 3 4
  • Preproenkephalin B 2 3
  • Preprodynorphin 3 4
  • Leu-Enkephalin 2 3
  • Leumorphin 2 3
  • Rimorphin 2 3
  • Spinocerebellar Ataxia 23 2
  • Beta-Neoendorphin 2
  • Dynorphin 2
  • PENKB 3
  • SCA23 3
  • ADCA 3

External Ids for PDYN Gene

Previous HGNC Symbols for PDYN Gene

  • SCA23

Previous GeneCards Identifiers for PDYN Gene

  • GC20M001947
  • GC20M001954

Summaries for PDYN Gene

Entrez Gene Summary for PDYN Gene

  • The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for PDYN Gene

PDYN (Prodynorphin) is a Protein Coding gene. Diseases associated with PDYN include spinocerebellar ataxia 23 and spinocerebellar ataxia type23. Among its related pathways are Signaling by GPCR and Spinal Cord Injury. GO annotations related to this gene include opioid peptide activity. An important paralog of this gene is PENK.

UniProtKB/Swiss-Prot for PDYN Gene

  • Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).

  • Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).

  • Leumorphin has a typical opiod activity and may have anti-apoptotic effect.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDYN Gene

Genomics for PDYN Gene

Regulatory Elements for PDYN Gene

Genomic Location for PDYN Gene

Chromosome:
20
Start:
1,978,756 bp from pter
End:
1,994,285 bp from pter
Size:
15,530 bases
Orientation:
Minus strand

Genomic View for PDYN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDYN Gene

Proteins for PDYN Gene

  • Protein details for PDYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01213-PDYN_HUMAN
    Recommended name:
    Proenkephalin-B
    Protein Accession:
    P01213
    Secondary Accessions:
    • A8K0Q3

    Protein attributes for PDYN Gene

    Size:
    254 amino acids
    Molecular mass:
    28385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDYN Gene

Proteomics data for PDYN Gene at MOPED

Post-translational modifications for PDYN Gene

  • The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDYN Gene

Antibody Products

No data available for DME Specific Peptides for PDYN Gene

Domains & Families for PDYN Gene

Gene Families for PDYN Gene

Suggested Antigen Peptide Sequences for PDYN Gene

Graphical View of Domain Structure for InterPro Entry

P01213

UniProtKB/Swiss-Prot:

PDYN_HUMAN :
  • Belongs to the opioid neuropeptide precursor family.
Family:
  • Belongs to the opioid neuropeptide precursor family.
genes like me logo Genes that share domains with PDYN: view

Function for PDYN Gene

Molecular function for PDYN Gene

GENATLAS Biochemistry:
pro-dynorphin
UniProtKB/Swiss-Prot Function:
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
UniProtKB/Swiss-Prot Function:
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).
UniProtKB/Swiss-Prot Function:
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.

Gene Ontology (GO) - Molecular Function for PDYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001515 opioid peptide activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PDYN: view
genes like me logo Genes that share phenotypes with PDYN: view

Animal Models for PDYN Gene

MGI Knock Outs for PDYN:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDYN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PDYN Gene

Localization for PDYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDYN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDYN Gene COMPARTMENTS Subcellular localization image for PDYN gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA 9047294
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PDYN: view

Pathways & Interactions for PDYN Gene

genes like me logo Genes that share pathways with PDYN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PDYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with PDYN: view

No data available for SIGNOR curated interactions for PDYN Gene

Drugs & Compounds for PDYN Gene

(47) Drugs for PDYN Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amphetamine Approved, Illicit Pharma 96
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Buprenorphine Approved, Illicit, Investigational Pharma Antagonist 365
Cocaine Approved, Illicit Pharma 441
Dopamine Approved Pharma Full agonist, Agonist 2814

(29) Additional Compounds for PDYN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[3h]diprenorphine
11 deoxycortisol
6-hydroxydopamine
  • 2,4,5-Trihydroxyphenethylamine
  • 5-(2-Aminoethyl)-1,2,4-benzenetriol
  • 6-Hydroxy-Dopamine
  • 6-Hydroxydopamine
  • Topamine
1199-18-4
adenylate
CATECHOLAMINE
genes like me logo Genes that share compounds with PDYN: view

Transcripts for PDYN Gene

mRNA/cDNA for PDYN Gene

Unigene Clusters for PDYN Gene

Prodynorphin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDYN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDYN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5:
SP6: - - - - -
SP7: - - - - - -
SP8: - - -

Relevant External Links for PDYN Gene

GeneLoc Exon Structure for
PDYN
ECgene alternative splicing isoforms for
PDYN

Expression for PDYN Gene

mRNA expression in normal human tissues for PDYN Gene

mRNA differential expression in normal tissues according to GTEx for PDYN Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x21.4), Brain - Caudate (basal ganglia) (x11.3), and Brain - Putamen (basal ganglia) (x6.4).

Protein differential expression in normal tissues from HIPED for PDYN Gene

This gene is overexpressed in Testis (25.8), Lymph node (10.6), and Ovary (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDYN Gene



SOURCE GeneReport for Unigene cluster for PDYN Gene Hs.22584

genes like me logo Genes that share expression patterns with PDYN: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PDYN Gene

Orthologs for PDYN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDYN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDYN 35
  • 82.02 (n)
  • 74.41 (a)
PDYN 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDYN 35
  • 84.91 (n)
  • 78.35 (a)
PDYN 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdyn 35
  • 74.97 (n)
  • 67.63 (a)
Pdyn 16
Pdyn 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDYN 35
  • 98.82 (n)
  • 98.03 (a)
PDYN 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdyn 35
  • 76.76 (n)
  • 68.46 (a)
oppossum
(Monodelphis domestica)
Mammalia PDYN 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDYN 35
  • 58.37 (n)
  • 48.36 (a)
PDYN 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDYN 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pdyn 35
  • 51.8 (n)
  • 46.32 (a)
pdyn 36
  • 35 (a)
OneToMany
pdyn 36
  • 35 (a)
OneToMany
Species with no ortholog for PDYN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDYN Gene

ENSEMBL:
Gene Tree for PDYN (if available)
TreeFam:
Gene Tree for PDYN (if available)

Paralogs for PDYN Gene

Paralogs for PDYN Gene

genes like me logo Genes that share paralogs with PDYN: view

Variants for PDYN Gene

Sequence variations from dbSNP and Humsavar for PDYN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_064913 Spinocerebellar ataxia 23 (SCA23)
VAR_064914 Spinocerebellar ataxia 23 (SCA23)
VAR_064915 Spinocerebellar ataxia 23 (SCA23)
VAR_064916 Spinocerebellar ataxia 23 (SCA23)
VAR_072266 Spinocerebellar ataxia 23 (SCA23)

Structural Variations from Database of Genomic Variants (DGV) for PDYN Gene

Variant ID Type Subtype PubMed ID
nsv470535 CNV Gain 18288195

Variation tolerance for PDYN Gene

Residual Variation Intolerance Score: 51.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDYN Gene

HapMap Linkage Disequilibrium report
PDYN
Human Gene Mutation Database (HGMD)
PDYN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDYN Gene

Disorders for PDYN Gene

MalaCards: The human disease database

(23) MalaCards diseases for PDYN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 23
  • sca23
spinocerebellar ataxia type23
  • sca 23
nasal cavity adenocarcinoma
  • adenocarcinoma of the nasal cavity
cutaneous solitary mastocytoma
  • solitary mastocytoma of skin
temporal lobe epilepsy
  • epilepsy, temporal lobe
- elite association
Search PDYN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PDYN_HUMAN
  • Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269 PubMed:21035104, ECO:0000269 PubMed:21712028, ECO:0000269 PubMed:23108490, ECO:0000269 PubMed:23471613}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PDYN

Genetic Association Database (GAD)
PDYN
Human Genome Epidemiology (HuGE) Navigator
PDYN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDYN
genes like me logo Genes that share disorders with PDYN: view

No data available for Genatlas for PDYN Gene

Publications for PDYN Gene

  1. Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients. (PMID: 20376782) Mousa S.A. … SchAofer M. (Histol. Histopathol. 2010) 23 67
  2. Activation of the basal forebrain by the orexin/hypocretin neurones. (PMID: 19723027) Arrigoni E. … Scammell T.E. (Acta Physiol (Oxf) 2010) 23 67
  3. Reduction of cell proliferation and potentiation of Fas-induced apoptosis by the selective kappa-opioid receptor agonist U50 488 in the multiple myeloma LP-1 cells. (PMID: 20163878) Kerros C. … Allouche S. (J. Neuroimmunol. 2010) 23 67
  4. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. (PMID: 20201854) Yuferov V. … Kreek M.J. (Ann. N. Y. Acad. Sci. 2010) 23 67
  5. Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23. (PMID: 21035104) Bakalkin G. … Verbeek D.S. (Am. J. Hum. Genet. 2010) 2 67

Products for PDYN Gene

Sources for PDYN Gene

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