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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDSS2 Gene

protein-coding   GIFtS: 53
GCID: GC06M107473

prenyl (decaprenyl) diphosphate synthase, subunit 2

(Previous name: chromosome 6 open reading frame 210 )
(Previous symbol: C6orf210)
 Explore 10 diseases affiliated with
PDSS2 via our new
 Human Malady Compendium 
Biological research products
for PDSS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 21 2     COQ10D32
C6orf2101 2 3 5     Decaprenyl Pyrophosphate Synthetase Subunit 22
DLP12 3 5     Decaprenyl-Diphosphate Synthase Subunit 22
BA59I9.31     HDLP11
All-Trans-Decaprenyl-Diphosphate Synthase Subunit 22 3     Subunit 2 Of Decaprenyl Diphosphate Synthase2
Decaprenyl Pyrophosphate Synthase Subunit 22 3     EC 2.5.1.913
Chromosome 6 Open Reading Frame 2101     Candidate Tumor Suppressor Protein3

External Ids:    HGNC: 230411   Entrez Gene: 571072   Ensembl: ENSG000001644947   OMIM: 6105645   UniProtKB: Q86YH63   

Export aliases for PDSS2 gene to outside databases

Previous GC identifers: GC06M107581 GC06M105044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDSS2:
The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one
of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl
pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q
biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: DLP1_HUMAN, Q86YH6
Function: Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10

Gene Wiki entry for PDSS2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDSS2 gene promoter:
         TBP   AML1a   Egr-1   NF-kappaB   MEF-2A   AREB6   Egr-2   S8   ARP-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDSS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDSS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDSS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

PDSS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDSS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M107473:  view genomic region     (about GC identifiers)

Start:
107,473,761 bp from pter      End:
107,780,779 bp from pter
Size:
307,019 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DLP1_HUMAN, Q86YH6 (See protein sequence)
Recommended Name: Decaprenyl-diphosphate synthase subunit 2  
Size: 399 amino acids; 44129 Da
Subunit: Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits
Subcellular location: Mitochondrion (Potential)
Sequence caution: Sequence=AAH29491.1; Type=Frameshift; Positions=28; Sequence=CAH73572.1; Type=Erroneous gene model
prediction; Sequence=CAI22355.1; Type=Erroneous gene model prediction;
Secondary accessions: Q33DR4 Q4G158 Q5VU38 Q5VU39 Q9NR58
Alternative splicing: 2 isoforms:  Q86YH6-1   Q86YH6-2   

Explore the universe of human proteins at neXtProt for PDSS2: NX_Q86YH6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YH6

  • PDSS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065114.3  
    ENSEMBL proteins: 
     ENSP00000358033   ENSP00000392613   ENSP00000358027   ENSP00000399691  
    Reactome Protein details: Q86YH6
    Human Recombinant Protein Products: 
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    Novus Biologicals PDSS2 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PDSS2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--


    PDSS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PDSS2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PDSS2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000092 Polyprenyl_synt
     IPR017446 Polyprenyl_synth-rel
     IPR008949 Terpenoid_synth

    Graphical View of Domain Structure for InterPro Entry Q86YH6

    ProtoNet protein and cluster: Q86YH6

    UniProtKB/Swiss-Prot: DLP1_HUMAN, Q86YH6
    Similarity: Belongs to the FPP/GGPP synthase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DLP1_HUMAN, Q86YH6
    Function: Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10
    Catalytic activity: (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl
    diphosphate

    Enzyme Number (IUBMB): EC 2.5.1.911

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDSS2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate PDSS2 (see all 49):
    hsa-miR-411* hsa-miR-379* hsa-miR-3655 hsa-miR-513a-5p hsa-miR-30d hsa-miR-578 hsa-miR-766 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPDSS2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDSS2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000010contributes to trans-hexaprenyltranstransferase activity IDA16262699
    GO:0046982protein heterodimerization activity IDA16262699
    GO:0050347trans-octaprenyltranstransferase activity IEA--


    PDSS2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PDSS2:
     Decreased TP53 protein express  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for PDSS2: Pdss2tm1.2Jdhu Pdss2tm1.1Dalg
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Pdss2):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  renal/urinary system  respiratory system  skeleton 

    PDSS2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    2all-trans-decaprenyl diphosphate biosynthesis
    all-trans-decaprenyl diphosphate biosynthesis1.00
    3superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
    Terpenoid backbone biosynthesis0.71
    4Ubiquinone and other terpenoid-quinone biosynthesis
    Ubiquinol biosynthesis0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for PDSS2 
        all-trans-decaprenyl diphosphate biosynthesis

    3        Reactome Pathways for PDSS2
        Metabolism
    Ubiquinol biosynthesis
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for PDSS2):
        Terpenoid backbone biosynthesis

    UniProtKB/Swiss-Prot: DLP1_HUMAN, Q86YH6
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis


    PDSS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDSS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for PDSS2 (Q86YH62, 3 ENSP000003580334) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110239 I2D: score=1 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111115 I2D: score=1 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111823 I2D: score=1 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112447 I2D: score=1 STRING: ENSP00000244007
    SRCP129312, 3, ENSP000003509414MINT-8112975 I2D: score=1 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006744ubiquinone biosynthetic process IEA--
    GO:0008299isoprenoid biosynthetic process IDA16262699
    GO:0050878regulation of body fluid levels IEA--
    GO:0051290protein heterotetramerization IEA--


    PDSS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDSS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDSS2
    1 Novoseek chemical compound relationship for PDSS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dimethylallyl diphosphate 92.5 8 19209031 (2), 19188149 (1)

    Search CenterWatch for drugs/clinical trials and news about PDSS2 / DLP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDSS2 gene: 
    NM_020381.3  

    Unigene Cluster for PDSS2:

    Prenyl (decaprenyl) diphosphate synthase, subunit 2
    Hs.486095  [show with all ESTs]
    Unigene Representative Sequence: NM_020381
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369037(uc011eak.1 uc003prt.2 uc011eal.1 uc003pru.3)
    ENST00000449027 ENST00000369031(uc003prv.3) ENST00000453874

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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate PDSS2 (see all 49):
    hsa-miR-411* hsa-miR-379* hsa-miR-3655 hsa-miR-513a-5p hsa-miR-30d hsa-miR-578 hsa-miR-766 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPDSS2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDSS2 (see all 6)
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    Additional cDNA sequence: 

    AB210839.1 AF086233.1 AJ420575.1 AK225629.1 AK296717.1 AK301480.1 AK315804.1 AL832290.1 
    BC029491.1 BC039906.1 

    11 DOTS entries:

    DT.211653  DT.441803  DT.101978539  DT.107838  DT.91719219  DT.92423138  DT.407691  DT.102827977 
    DT.91987470  DT.95308376  DT.101971395 

    24/124 AceView cDNA sequences (see all 124):

    BX951249 CA443260 AI453717 AF086233 BQ717193 AA633846 BU690109 BX119736 
    AI241634 CA423080 BU197370 AL832290 BE669777 AA226990 BP338626 BF594439 
    CA425704 BI335846 AA314404 N95678 AI678112 BU608449 AA370499 CD630093 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDSS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PDSS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDSS2

    SOURCE GeneReport for Unigene cluster: Hs.486095
        SABiosciences Custom PCR Arrays for PDSS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDSS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDSS2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdss21 , 5 prenyl (solanesyl) diphosphate synthase, subunit 21, 5 87.64(n)1
    88.72(a)1
      10 (22.91 cM)5
    713651  NM_027772.21  NP_082048.21 
     432214865 
    chicken
    (Gallus gallus)
    Aves PDSS21 prenyl (decaprenyl) diphosphate synthase, subunit 2 75.58(n)
    77.27(a)
      421777  XM_419804.3  XP_419804.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDSS26
    --
    75(a)
    1 ↔ 1
    1(189663680-189779788)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.190882 Transcribed sequences 85.78(n)    AL888078.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pdss21 prenyl (decaprenyl) diphosphate synthase, subunit 2 66.57(n)
    66.95(a)
      436624  NM_001002351.1  NP_001002351.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105851 CG10585 48.86(n)
    42.23(a)
      40323  NM_141020.3  NP_649277.1 


    ENSEMBL Gene Tree for PDSS2 (if available)
    TreeFam Gene Tree for PDSS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDSS2 gene
    PDSS12  

    PDSS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PDSS2
    PGOHUM00000235599


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4805 NCBI SNPs in PDSS2 are shown (see all 4805    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1182039561,2
    Cpathogenic205198863(-) TCCCTC/TGGAGG 2 S L mis11Minor allele frequency- T:0.00NA 4550
    rs14140391,2
    H--105044446(-) GCCTGC/ATGAGT 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs37929681,2
    C,H,--105044570(-) CTTCGG/AGACCT 1 -- ds50016Minor allele frequency- A:0.02EA NS 1832
    rs737637331,2
    C,--105044586(+) AGCAAG/AGCAGG 1 -- ds50012Minor allele frequency- A:0.15WA 120
    rs592956671,2
    --105044832(+) TATCTC/TGTTTA 1 -- ut310--------
    rs2018034351,2
    C--105044854(-) AGTGTA/GAAAAA 1 -- ut310--------
    rs37632111,2
    F--105045054(-) TTGGAT/CGTGCA 1 -- ut311Minor allele frequency- C:0.00EA 732
    rs737637341,2
    C,--105045265(+) AGTACA/GCTTAA 1 -- ut312Minor allele frequency- G:0.14WA 120
    rs115482491,2
    --105045289(+) ACAATA/TCATTA 1 -- ut310--------
    rs69152721,2
    C,A,--105046107(+) caggcA/Ggatca 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PDSS2 (107473761 - 107723761 bp, first 250kb of PDSS2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for PDSS2
         5 CNVs: 64627 99658 4504 93943 51784
         4 Indels: 81531 93941 81530 93942
    Human Gene Mutation Database (HGMD): PDSS2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PDSS2 for disorders           About GeneDecksing

    OMIM gene information: 610564   
    OMIM disorders: 607426  
    UniProtKB/Swiss-Prot: DLP1_HUMAN, Q86YH6
  • Defects in PDSS2 are the cause of coenzyme Q10 deficiency, primary, type 3 (COQ10D3) [MIM:614652]. A fatal
  • encephalomyopathic form of coenzyme Q10 deficiency with nephrotic syndrome. Coenzyme Q10 deficiency is an autosomal
    recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an
    encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and
    renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth
    retardation; and an isolated myopathic form

    10 diseases for PDSS2:    About MalaCards
    cleft lip/palate    cleft lip    encephalomyopathy    nephrotic syndrome
    gastric cancer    nephropathy    pneumonia    tuberculosis
    melanoma    mycobacterium tuberculosis

    1 Novoseek disease relationship for PDSS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 18 12 19188149 (3), 19209031 (2)

    Human Genome Epidemiology (HuGE) Navigator: PDSS2 (7 documents)

    Export disorders for PDSS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDSS2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with PDSS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. (PubMed id 16262699)1, 2, 3 Saiki R.... Kawamukai M. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line. (PubMed id 19209031)1, 9 Chen P....Niu Y.Y. (2009)
    5. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. (PubMed id 17186472)2, 9 Lopez L.C.... Hirano M. (2006)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Genotype-phenotype correlations in non-Finnish congen ital nephrotic syndrome. (PubMed id 20507940)1 Machuca E....Antignac C. (2010)
    9. A subunit of decaprenyl diphosphate synthase stabiliz es octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecu lar weight complex. (PubMed id 20051244)1 Cui T.Z....Kawamukai M. (2010)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57107 HGNC: 23041 AceView: C6orf210 Ensembl:ENSG00000164494 euGenes: HUgn57107
    ECgene: PDSS2 Kegg: 57107 H-InvDB: PDSS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDSS2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PDSS2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDSS2 gene:
    Search GeneIP for patents involving PDSS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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