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Aliases for PDSS1 Gene

Aliases for PDSS1 Gene

  • Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 2 3 5
  • All-Trans-Decaprenyl-Diphosphate Synthase Subunit 1 3 4
  • Decaprenyl Pyrophosphate Synthase Subunit 1 3 4
  • Trans-Prenyltransferase 1 3 4
  • TPT 1 3 4
  • TPRT 3 4
  • Subunit 1 Of Decaprenyl Diphosphate Synthase 3
  • Decaprenyl-Diphosphate Synthase Subunit 1 3
  • Polyprenyl Pyrophosphate Synthetase 3
  • Trans-Prenyltransferase (TPT) 3
  • Coenzyme Q1 Homolog (Yeast) 2
  • Trans-Prenyltransferase 2
  • Coenzyme Q1 Homolog 3
  • EC 4
  • COQ10D2 3
  • HDPS1 3
  • COQ1 3
  • DPS1 4
  • TPT 3
  • DPS 3
  • SPS 3

External Ids for PDSS1 Gene

Previous HGNC Symbols for PDSS1 Gene

  • TPRT

Previous GeneCards Identifiers for PDSS1 Gene

  • GC10P027027
  • GC10P026986

Summaries for PDSS1 Gene

Entrez Gene Summary for PDSS1 Gene

  • The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDSS1 Gene

PDSS1 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1) is a Protein Coding gene. Diseases associated with PDSS1 include Coenzyme Q10 Deficiency, Primary, 2 and Pdss1-Related Coenzyme Q10 Deficiency. Among its related pathways are Ubiquinol biosynthesis and Metabolism. GO annotations related to this gene include protein heterodimerization activity and trans-octaprenyltranstransferase activity. An important paralog of this gene is PDSS2.

UniProtKB/Swiss-Prot for PDSS1 Gene

  • Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.

Gene Wiki entry for PDSS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDSS1 Gene

Genomics for PDSS1 Gene

Regulatory Elements for PDSS1 Gene

Enhancers for PDSS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PDSS1 on UCSC Golden Path with GeneCards custom track

Promoters for PDSS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PDSS1 Gene

26,697,424 bp from pter
26,748,564 bp from pter
51,141 bases
Plus strand

Genomic View for PDSS1 Gene

Genes around PDSS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDSS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDSS1 Gene

Proteins for PDSS1 Gene

  • Protein details for PDSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Decaprenyl-diphosphate synthase subunit 1
    Protein Accession:
    Secondary Accessions:
    • Q53F75
    • Q6P473
    • Q86WQ8
    • Q9Y2W5

    Protein attributes for PDSS1 Gene

    415 amino acids
    Molecular mass:
    46261 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.

    Alternative splice isoforms for PDSS1 Gene


neXtProt entry for PDSS1 Gene

Post-translational modifications for PDSS1 Gene

  • Ubiquitination at Lys 97 and Lys 104
  • Modification sites at PhosphoSitePlus

Other Protein References for PDSS1 Gene

No data available for DME Specific Peptides for PDSS1 Gene

Domains & Families for PDSS1 Gene

Protein Domains for PDSS1 Gene

Suggested Antigen Peptide Sequences for PDSS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FPP/GGPP synthase family.
  • Belongs to the FPP/GGPP synthase family.
genes like me logo Genes that share domains with PDSS1: view

No data available for Gene Families for PDSS1 Gene

Function for PDSS1 Gene

Molecular function for PDSS1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.
UniProtKB/Swiss-Prot Function:
Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.

Enzyme Numbers (IUBMB) for PDSS1 Gene

Gene Ontology (GO) - Molecular Function for PDSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000010 contributes_to trans-hexaprenyltranstransferase activity IDA 16262699
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA,IDA 16262699
GO:0050347 trans-octaprenyltranstransferase activity IEA --
genes like me logo Genes that share ontologies with PDSS1: view
genes like me logo Genes that share phenotypes with PDSS1: view

Human Phenotype Ontology for PDSS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for PDSS1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PDSS1 Gene

Localization for PDSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDSS1 Gene


Subcellular locations from

Jensen Localization Image for PDSS1 Gene COMPARTMENTS Subcellular localization image for PDSS1 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for PDSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
GO:1990234 transferase complex IEA,IDA 16262699
genes like me logo Genes that share ontologies with PDSS1: view

Pathways & Interactions for PDSS1 Gene

genes like me logo Genes that share pathways with PDSS1: view

Pathways by source for PDSS1 Gene

1 BioSystems pathway for PDSS1 Gene
1 KEGG pathway for PDSS1 Gene

UniProtKB/Swiss-Prot Q5T2R2-DPS1_HUMAN

  • Pathway: Cofactor biosynthesis; ubiquinone biosynthesis.

Gene Ontology (GO) - Biological Process for PDSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006744 ubiquinone biosynthetic process TAS --
GO:0008299 isoprenoid biosynthetic process IEA,IDA 16262699
GO:0051290 protein heterotetramerization IEA --
genes like me logo Genes that share ontologies with PDSS1: view

No data available for SIGNOR curated interactions for PDSS1 Gene

Drugs & Compounds for PDSS1 Gene

(1) Drugs for PDSS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopentenyl pyrophosphate Experimental Pharma 0

(5) Additional Compounds for PDSS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
all-trans-Decaprenyl diphosphate
Farnesyl pyrophosphate
  • (2E,6E)-Farnesyl diphosphate
  • (2E,6E)-Farnesyl pyrophosphate
  • (all-E)-Farnesyl diphosphate
  • (E,E)-Farnesyl diphosphate
  • (E,E)-Farnesyl pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with PDSS1: view

Transcripts for PDSS1 Gene

Unigene Clusters for PDSS1 Gene

Prenyl (decaprenyl) diphosphate synthase, subunit 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDSS1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP6: -

Relevant External Links for PDSS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDSS1 Gene

mRNA expression in normal human tissues for PDSS1 Gene

Protein differential expression in normal tissues from HIPED for PDSS1 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDSS1 Gene

Protein tissue co-expression partners for PDSS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDSS1 Gene:


SOURCE GeneReport for Unigene cluster for PDSS1 Gene:

genes like me logo Genes that share expression patterns with PDSS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PDSS1 Gene

Orthologs for PDSS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDSS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDSS1 34
  • 84.95 (n)
  • 86.17 (a)
PDSS1 35
  • 84 (a)
(Canis familiaris)
Mammalia PDSS1 34
  • 90.95 (n)
  • 94.18 (a)
PDSS1 35
  • 93 (a)
(Mus musculus)
Mammalia Pdss1 34
  • 86.3 (n)
  • 85.89 (a)
Pdss1 16
Pdss1 35
  • 83 (a)
(Pan troglodytes)
Mammalia PDSS1 34
  • 97.67 (n)
  • 97.35 (a)
PDSS1 35
  • 96 (a)
(Rattus norvegicus)
Mammalia Pdss1 34
  • 86.06 (n)
  • 86.63 (a)
(Monodelphis domestica)
Mammalia PDSS1 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PDSS1 35
  • 81 (a)
(Gallus gallus)
Aves PDSS1 34
  • 80.4 (n)
  • 85.3 (a)
PDSS1 35
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 79 (a)
-- 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdss1 34
  • 76.71 (n)
  • 80.82 (a)
(Danio rerio)
Actinopterygii pdss1 34
  • 69.12 (n)
  • 72.06 (a)
wufc11f12 34
pdss1 35
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000591 34
  • 54 (n)
  • 51.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta qless 34
  • 55.38 (n)
  • 55.9 (a)
qless 35
  • 43 (a)
(Caenorhabditis elegans)
Secernentea coq-1 34
  • 54.09 (n)
  • 50.89 (a)
coq-1 35
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER004W 34
  • 51.34 (n)
  • 47.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17183g 34
  • 53.33 (n)
  • 47.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COQ1 34
  • 51.58 (n)
  • 43.35 (a)
COQ1 35
  • 27 (a)
COQ1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons GPS1 34
  • 49.95 (n)
  • 41 (a)
(Oryza sativa)
Liliopsida Os06g0678200 34
  • 50.82 (n)
  • 43.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02305 34
  • 49.95 (n)
  • 46.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dps1 34
  • 53.18 (n)
  • 49.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
Species where no ortholog for PDSS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDSS1 Gene

Gene Tree for PDSS1 (if available)
Gene Tree for PDSS1 (if available)

Paralogs for PDSS1 Gene

Paralogs for PDSS1 Gene Pseudogenes for PDSS1 Gene

genes like me logo Genes that share paralogs with PDSS1: view

Variants for PDSS1 Gene

Sequence variations from dbSNP and Humsavar for PDSS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs119463988 Coenzyme Q10 deficiency, primary, 2 (COQ10D2) 26,735,477(+) GATGA(G/T)GTATT nc-transcript-variant, reference, missense
rs1947788 -- 26,695,801(-) CCAAC(A/G)TTACT upstream-variant-2KB
rs1960383 -- 26,701,071(-) gccca(A/G)ttccc intron-variant
rs1985337 -- 26,722,423(+) CTTAC(A/G)gccgg intron-variant
rs2011849 -- 26,695,867(-) AAGAA(A/G)AAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PDSS1 Gene

Variant ID Type Subtype PubMed ID
dgv140n67 CNV loss 20364138
dgv382n106 CNV deletion 24896259
esv2670796 CNV deletion 23128226
esv26715 CNV gain+loss 19812545
esv2734406 CNV deletion 23290073
esv2761585 CNV loss 21179565
esv3263829 CNV deletion 24192839
esv3415799 CNV duplication 20981092
esv3546052 CNV deletion 23714750
esv3622697 CNV loss 21293372
esv991084 CNV deletion 20482838
nsv1069034 CNV deletion 25765185
nsv24807 CNV deletion 16902084
nsv550233 CNV loss 21841781
nsv550234 CNV loss 21841781
nsv550235 CNV loss 21841781
nsv819742 CNV gain 19587683
nsv821589 CNV deletion 20802225
nsv825315 CNV loss 20364138
nsv825316 CNV loss 20364138

Variation tolerance for PDSS1 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDSS1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDSS1 Gene

Disorders for PDSS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDSS1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
coenzyme q10 deficiency, primary, 2
  • coq10d2
pdss1-related coenzyme q10 deficiency
  • coenzyme q10 deficiency, primary, 2
glutaric acidemia iic
  • glutaric acidemia iia
- elite association - COSMIC cancer census association via MalaCards
Search PDSS1 in MalaCards View complete list of genes associated with diseases


  • Coenzyme Q10 deficiency, primary, 2 (COQ10D2) [MIM:614651]: An autosomal recessive multisystem disorder characterized by early-onset deafness, optic atrophy, mild mental retardation, peripheral neuropathy, obesity, livedo reticularis, and cardiac valvulopathy. {ECO:0000269 PubMed:17332895}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PDSS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PDSS1: view

No data available for Genatlas for PDSS1 Gene

Publications for PDSS1 Gene

  1. Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders. (PMID: 17332895) Mollet J. … Rotig A. (J. Clin. Invest. 2007) 3 4 22 65
  2. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. (PMID: 10972372) Roetig A. … Rustin P. (Lancet 2000) 2 3 4 65
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65

Products for PDSS1 Gene

Sources for PDSS1 Gene

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