Aliases for PDS5B Gene
External Ids for PDS5B Gene
Previous HGNC Symbols for PDS5B Gene
Previous GeneCards Identifiers for PDS5B Gene
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010]
GeneCards Summary for PDS5B Gene
UniProtKB/Swiss-Prot for PDS5B Gene
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.