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PDS5B Gene

protein-coding   GIFtS: 56
GCID: GC13P033160

PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae)

(Previous name: androgen-induced proliferation inhibitor)
(Previous symbol: APRIN)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae)1 2     CG0082
Androgen-Induced Proliferation Inhibitor1 2 3     Androgen Induced Inhibitor Of Proliferation2
APRIN1 2 3     Androgen-Induced Shutoff 32
AS32 3 5     Sister Chromatid Cohesion Protein PDS5 Homolog B2
Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS32 3     KIAA09793

External Ids:    HGNC: 204181   Entrez Gene: 230472   Ensembl: ENSG000000836427   OMIM: 6053335   UniProtKB: Q9NTI53   

Export aliases for PDS5B gene to outside databases

Previous GC identifers: GC13P032059 GC13P013971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDS5B Gene:
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion
complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and
meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.
(provided by RefSeq, May 2010)

GeneCards Summary for PDS5B Gene:
PDS5B (PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is PDS5A.

UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
Function: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with
chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that
chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Plays a role in androgen-induced proliferative arrest in prostate cells

Gene Wiki entry for PDS5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PDS5B gene promoter:
         AhR   Sox5   AP-1   p53   ATF-2   MyoD   FOXJ2 (long isoform)   Chx10   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDS5B promoter sequence
   Search Chromatin IP Primers for PDS5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDS5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3   Ensembl cytogenetic band:  13q13.1   HGNC cytogenetic band: 13q12.3

PDS5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDS5B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P033160:  view genomic region     (about GC identifiers)

Start:
33,160,564 bp from pter      End:
33,352,158 bp from pter
Size:
191,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5 (See protein sequence)
Recommended Name: Sister chromatid cohesion protein PDS5 homolog B  
Size: 1447 amino acids; 164667 Da
Subunit: Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL
(via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive
(Probable)
Sequence caution: Sequence=BAA76823.2; Type=Erroneous initiation;
Secondary accessions: Q5R3S3 Q5W0K8 Q6NSC3 Q8IXT6 Q9H5N8 Q9Y2I5 Q9Y451
Alternative splicing: 5 isoforms:  Q9NTI5-1   Q9NTI5-2   Q9NTI5-3   Q9NTI5-4   Q9NTI5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDS5B: NX_Q9NTI5

Explore proteomics data for PDS5B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys356
  • Modification sites at PhosphoSitePlus

  • See PDS5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055847.1  
    ENSEMBL proteins: 
     ENSP00000313851   ENSP00000401619   ENSP00000407005  
    Reactome Protein details: Q9NTI5

    PDS5B Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for PDS5B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017956 AT_hook_DNA-bd_motif
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NTI5

    ProtoNet protein and cluster: Q9NTI5

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
    Similarity: Belongs to the PDS5 family
    Similarity: Contains 3 A.T hook DNA-binding domains
    Similarity: Contains 1 HEAT repeat


    Find genes that share domains with PDS5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDS5B_HUMAN, Q9NTI5
    Function: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with
    chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that
    chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
    Plays a role in androgen-induced proliferative arrest in prostate cells
    Induction: By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum
    levels occur 18-20 hours after androgen exposure

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI15837422
    GO:0005524ATP binding TAS10215036
         
    Find genes that share ontologies with PDS5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDS5B:
     Increased G1 DNA content 

         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pds5b):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging 
     nervous system  reproductive system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with PDS5B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pds5btm1Jmi for PDS5B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDS5B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDS5B

    miRNA
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    miRTarBase miRNAs that target PDS5B:
    hsa-mir-92a-3p (MIRT049126), hsa-mir-27a-3p (MIRT007124)

    Block miRNA regulation of human, mouse, rat PDS5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDS5B (see all 46):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidPDS5B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDS5B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PDS5B (NM_015032)
    Sino Biological Human cDNA Clone for PDS5B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDS5B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDS5B_HUMAN, Q9NTI5: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000785chromatin IDA16682347
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome TAS--

    Find genes that share ontologies with PDS5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDS5B About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.78
    Establishment of Sister Chromatid Cohesion0.00
    5Mitotic Telophase/Cytokinesis
    Mitotic Telophase/Cytokinesis
    Cohesin Loading onto Chromatin0.00


    Find genes that share SuperPaths with PDS5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for PDS5B
        Cohesin Loading onto Chromatin
    Establishment of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDS5B
    Interactions:

        Search GeneGlobe Interaction Network for PDS5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDS5B (Q9NTI51, 2, 3 ENSP000003138514) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA2P515871, 2EBI-1175604,EBI-79792 MINT-8384735 MINT-8392646 MINT-8384678 MINT-8384908 MINT-8384717 MINT-8392542 MINT-8384781 MINT-8384942 MINT-8392595 MINT-8384857 MINT-8384958 MINT-8385051 MINT-8392612 MINT-8384892 MINT-8385019 MINT-8384999 MINT-8385117 MINT-8385079 MINT-8384691 MINT-8391711 MINT-8392578 MINT-8384926 MINT-8385033 MINT-8392560 MINT-8385100 MINT-8392629
    SMC3Q9UQE71, 2, 3, ENSP000003547204EBI-1175604,EBI-80718 MINT-8385079 MINT-8385100 I2D: score=3 STRING: ENSP00000354720
    STAG1Q8WVM71, 3, ENSP000003726894EBI-1175604,EBI-1175097 I2D: score=3 STRING: ENSP00000372689
    RAD51Q066092MINT-8384735 MINT-8384781 MINT-8385051 MINT-8385019 MINT-8384999 MINT-8384642
    RAD21O602161, 2, 3, ENSP000002973384EBI-1175604,EBI-80739 MINT-8385079 MINT-8385100 I2D: score=3 STRING: ENSP00000297338
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007064mitotic sister chromatid cohesion IMP15855230
    GO:0008283cell proliferation TAS10963680
    GO:0008285negative regulation of cell proliferation IDA10963680
    GO:0042127regulation of cell proliferation IDA10963680

    Find genes that share ontologies with PDS5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDS5B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDS5B gene (2 alternative transcripts): 
    NM_015032.3  NM_015928.1  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315596(uc010abf.3 uc010abg.3) ENST00000482955 ENST00000498550(uc001uuo.3 uc010teb.2)
    ENST00000450460 ENST00000493653(uc001uun.3) ENST00000466078 ENST00000481616
    ENST00000447833 ENST00000474274
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PDS5B (see all 46):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidPDS5B 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PDS5B
      QuantiFast Probe-based Assays in human, mouse, rat PDS5B

    Selected AceView cDNA sequences (see all 113):

    CB215704 AL137201 CB132602 F09972 CA394375 BC026240 AA563884 CB129904 
    F12354 AA333118 CA448154 AB023196 BM794657 BQ128161 AW629426 CA405800 
    AI636348 AI911784 NM_015032 AI680124 BX474034 AL602527 BG571128 BM825722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDS5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATGAAAA
    PDS5B Expression
    About this image


    PDS5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PDS5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDS5B Protein Expression

    UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
    Tissue specificity: Widely expressed

        Custom PCR Arrays for PDS5B
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    QuantiFast Probe-based Assays in human, mouse, rat PDS5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDS5B gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pds5b1 , 5 PDS5, regulator of cohesion maintenance, homolog B more1, 5 89.78(n)1
    96.52(a)1
      5 (89.61 cM)5
    1007101  NM_175310.61  NP_780519.31 
     1506737395 
    chicken
    (Gallus gallus)
    Aves PDS5B1 PDS5, regulator of cohesion maintenance, homolog B more 84.14(n)
    93.51(a)
      418910  NM_001012827.2  NP_001012845.2 
    lizard
    (Anolis carolinensis)
    Reptilia PDS5B6
    PDS5, regulator of cohesion maintenance, homolog B...
    90(a)
    1 ↔ 1
    3(183560855-183659143)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.201292 Transcribed sequence with strong similarity to protein more 81.9(n)    BX760001.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pds5b1 PDS5, regulator of cohesion maintenance, homolog B more 72.14(n)
    83.14(a)
      565592  XM_688861.4  XP_693953.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta pds51 pds5 48.16(n)
    39.76(a)
      36286  NM_001259342.1  NP_001246271.1 
    worm
    (Caenorhabditis elegans)
    Secernentea evl-141 evl-14 41.93(n)
    25.31(a)
      175555  NM_065464.5  NP_497865.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PDS51 PDS5 41.09(n)
    22.87(a)
      855099   NP_013793.1 


    ENSEMBL Gene Tree for PDS5B (if available)
    TreeFam Gene Tree for PDS5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDS5B gene
    PDS5A2  
    1 SIMAP similar gene for PDS5B using alignment to 2 protein entries:     PDS5B_HUMAN (see all proteins):
    PDS5A

    Find genes that share paralogs with PDS5B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDS5B (see all 3854)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714231171,2
    C,F--13971951(+) CGGCCC/GCCACT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1451537331,2
    C--13971951(+) GGCCG-/CCCC  
            
    CCACT
    1 -- int10--------
    rs1860038951,2
    --13972296(+) CGGGCA/GGGGAC 1 -- int10--------
    rs112819351,2
    C--13974961(+) TTAAG-/TTT/  
      TTTAAG
    AAGCT
    2 -- cds10--------
    rs1390755021,2
    C--13977633(+) CTGGT-/CTCGAA
    CTCCTGGC
    CTCAG
    1 -- int10--------
    rs559446341,2
    C--13977709(+) GCGCCC/-TGGCC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs350914301,2
    C--13979435(+) GAGAC-/TATGTGT 1 -- int10--------
    rs2006574981,2
    C--13983341(+) CAATT-/CTCCTGCC 1 -- cds10--------
    rs1407831391,2
    C--13987162(+) ATTCA-/AAAC  
            
    AATGT
    1 -- int10--------
    rs2010079471,2
    --13990899(+) GTTAG-/CTCTTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PDS5B (33160564 - 33352158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PDS5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2448396CNV Deletion19546169
    esv2609555CNV Deletion19546169
    esv269913CNV Insertion20981092
    nsv507688CNV Insertion20534489
    nsv899970CNV Loss21882294
    nsv832577CNV Gain17160897
    nsv899969CNV Gain21882294

    Locus Specific Mutation Databases (LSDB): PDS5B

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDS5B
    DNA2.0 Custom Variant and Variant Library Synthesis for PDS5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605333    OMIM disorders: --


    Find genes that share disorders with PDS5B           About GenesLikeMe

    Genetic Association Database (GAD): PDS5B

    Export disorders for PDS5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDS5B gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with PDS5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus. (PubMed id 10215036)1, 2, 3, 9 Geck P.... Soto A.M. (J. Steroid Biochem. Mol. Biol. 1999)
    2. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. (PubMed id 10963680)1, 2, 9 Geck P.... Soto A.M. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J.... . (Mol. Psychiatry 2011)
    4. Sororin mediates sister chromatid cohesion by antagonizing wapl. (PubMed id 21111234)1, 2 Nishiyama T....Peters J.M. (Cell 2010)
    5. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. (PubMed id 15855230)1, 2 Losada A.... Hirano T. (J. Cell Sci. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    8. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 3 Couch F.J.... Simard J. (Genomics 1996)
    9. Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma. (PubMed id 18499069)1, 9 Zhang Y....Wang M. (J Genet Genomics 2008)
    10. Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells. (PubMed id 19737411)1, 9 Kunnev D....Ionov Y. (BMC Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23047 HGNC: 20418 AceView: APRIN Ensembl:ENSG00000083642 euGenes: HUgn23047
    ECgene: PDS5B H-InvDB: PDS5B

    (According to HUGE)
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    HUGE: KIAA0979

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDS5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDS5B gene:
    Search GeneIP for patents involving PDS5B

    Licensable Technologies for PDS5B gene:
     Tufts University:  AS3 Expression as a Prognostic and Therapeutic Marker in Prostate Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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