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Aliases for PDS5B Gene

Aliases for PDS5B Gene

  • PDS5 Cohesin Associated Factor B 2 3 5
  • Androgen-Induced Proliferation Inhibitor 2 3 4
  • Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS3 3 4
  • APRIN 3 4
  • AS3 3 4
  • PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae) 2
  • Androgen Induced Inhibitor Of Proliferation 3
  • Androgen-Induced Shutoff 3 3
  • KIAA0979 4
  • CG008 3

External Ids for PDS5B Gene

Previous HGNC Symbols for PDS5B Gene

  • APRIN

Previous GeneCards Identifiers for PDS5B Gene

  • GC13P032059
  • GC13P033160
  • GC13P013971

Summaries for PDS5B Gene

Entrez Gene Summary for PDS5B Gene

  • This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

GeneCards Summary for PDS5B Gene

PDS5B (PDS5 Cohesin Associated Factor B) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Mitotic Telophase/Cytokinesis. GO annotations related to this gene include binding. An important paralog of this gene is PDS5A.

UniProtKB/Swiss-Prot for PDS5B Gene

  • Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

Gene Wiki entry for PDS5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDS5B Gene

Genomics for PDS5B Gene

Regulatory Elements for PDS5B Gene

Enhancers for PDS5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDS5B on UCSC Golden Path with GeneCards custom track

Promoters for PDS5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDS5B on UCSC Golden Path with GeneCards custom track

Genomic Location for PDS5B Gene

Chromosome:
13
Start:
32,586,427 bp from pter
End:
32,778,020 bp from pter
Size:
191,594 bases
Orientation:
Plus strand

Genomic View for PDS5B Gene

Genes around PDS5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDS5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDS5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDS5B Gene

Proteins for PDS5B Gene

  • Protein details for PDS5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTI5-PDS5B_HUMAN
    Recommended name:
    Sister chromatid cohesion protein PDS5 homolog B
    Protein Accession:
    Q9NTI5
    Secondary Accessions:
    • Q5R3S3
    • Q5W0K8
    • Q6NSC3
    • Q8IXT6
    • Q9H5N8
    • Q9Y2I5
    • Q9Y451

    Protein attributes for PDS5B Gene

    Size:
    1447 amino acids
    Molecular mass:
    164667 Da
    Quaternary structure:
    • Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable).
    SequenceCaution:
    • Sequence=BAA76823.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PDS5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDS5B Gene

Proteomics data for PDS5B Gene at MOPED

Post-translational modifications for PDS5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDS5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDS5B Gene

Domains & Families for PDS5B Gene

Protein Domains for PDS5B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NTI5

UniProtKB/Swiss-Prot:

PDS5B_HUMAN :
  • Contains 3 A.T hook DNA-binding domains.
  • Belongs to the PDS5 family.
  • Contains 1 HEAT repeat.
Domain:
  • Contains 3 A.T hook DNA-binding domains.
Family:
  • Belongs to the PDS5 family.
Similarity:
  • Contains 1 HEAT repeat.
genes like me logo Genes that share domains with PDS5B: view

No data available for Gene Families for PDS5B Gene

Function for PDS5B Gene

Molecular function for PDS5B Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
UniProtKB/Swiss-Prot Induction:
By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.

Gene Ontology (GO) - Molecular Function for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS 10215036
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with PDS5B: view
genes like me logo Genes that share phenotypes with PDS5B: view

Animal Models for PDS5B Gene

MGI Knock Outs for PDS5B:

Animal Model Products

CRISPR Products

miRNA for PDS5B Gene

miRTarBase miRNAs that target PDS5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDS5B Gene

Localization for PDS5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDS5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDS5B Gene COMPARTMENTS Subcellular localization image for PDS5B gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome TAS --
genes like me logo Genes that share ontologies with PDS5B: view

Pathways & Interactions for PDS5B Gene

genes like me logo Genes that share pathways with PDS5B: view

Pathways by source for PDS5B Gene

Gene Ontology (GO) - Biological Process for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 regulation of cell proliferation IDA 10963680
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with PDS5B: view

No data available for SIGNOR curated interactions for PDS5B Gene

Drugs & Compounds for PDS5B Gene

No Compound Related Data Available

Transcripts for PDS5B Gene

Unigene Clusters for PDS5B Gene

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDS5B Gene

No ASD Table

Relevant External Links for PDS5B Gene

GeneLoc Exon Structure for
PDS5B
ECgene alternative splicing isoforms for
PDS5B

Expression for PDS5B Gene

mRNA expression in normal human tissues for PDS5B Gene

Protein differential expression in normal tissues from HIPED for PDS5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Lymph node (8.5), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDS5B Gene



SOURCE GeneReport for Unigene cluster for PDS5B Gene Hs.744901

mRNA Expression by UniProt/SwissProt for PDS5B Gene

Q9NTI5-PDS5B_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PDS5B: view

Protein tissue co-expression partners for PDS5B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PDS5B Gene

Orthologs for PDS5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDS5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDS5B 35
  • 93.9 (n)
  • 98.47 (a)
PDS5B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDS5B 35
  • 95.53 (n)
  • 99.17 (a)
PDS5B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pds5b 35
  • 89.78 (n)
  • 96.52 (a)
Pds5b 16
Pds5b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDS5B 35
  • 99.86 (n)
  • 100 (a)
PDS5B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pds5b 35
  • 86.44 (n)
  • 95.06 (a)
oppossum
(Monodelphis domestica)
Mammalia PDS5B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDS5B 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDS5B 35
  • 84.14 (n)
  • 93.51 (a)
PDS5B 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDS5B 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pds5b 35
  • 77.58 (n)
  • 86.93 (a)
Str.20129 35
zebrafish
(Danio rerio)
Actinopterygii pds5b 35
  • 72.14 (n)
  • 83.14 (a)
pds5b 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9260 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010643 35
  • 46.91 (n)
  • 40.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta pds5 35
  • 48.16 (n)
  • 39.76 (a)
pds5 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea evl-14 35
  • 41.93 (n)
  • 25.31 (a)
evl-14 36
  • 17 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL076W 35
  • 40.23 (n)
  • 23.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25806g 35
  • 41.39 (n)
  • 23.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDS5 35
  • 41.09 (n)
  • 22.87 (a)
PDS5 36
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00424 35
  • 40.46 (n)
  • 24.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pds5 35
  • 42.62 (n)
  • 26.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for PDS5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDS5B Gene

ENSEMBL:
Gene Tree for PDS5B (if available)
TreeFam:
Gene Tree for PDS5B (if available)

Paralogs for PDS5B Gene

Paralogs for PDS5B Gene

(1) SIMAP similar genes for PDS5B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDS5B: view

Variants for PDS5B Gene

Sequence variations from dbSNP and Humsavar for PDS5B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3492 -- 32,775,203(+) CATAC(A/G)TTTGT utr-variant-3-prime
rs3493 -- 32,775,230(+) CATAC(A/C/G)CATGG utr-variant-3-prime
rs129480 -- 32,585,091(-) ATTAT(C/G/T)TTTTT upstream-variant-2KB
rs399622 -- 32,638,648(-) AGCAT(G/T)CAAAT intron-variant
rs208409 -- 32,621,308(+) aaaat(A/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDS5B Gene

Variant ID Type Subtype PubMed ID
nsv899969 CNV Gain 21882294
nsv507688 CNV Insertion 20534489
esv2609555 CNV Deletion 19546169
nsv832577 CNV Gain 17160897
nsv899970 CNV Loss 21882294
esv269913 CNV Insertion 20981092
esv2448396 CNV Deletion 19546169

Variation tolerance for PDS5B Gene

Residual Variation Intolerance Score: 1.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PDS5B Gene

Disorders for PDS5B Gene

Relevant External Links for PDS5B

Genetic Association Database (GAD)
PDS5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDS5B

No disorders were found for PDS5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDS5B Gene

Publications for PDS5B Gene

  1. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus. (PMID: 10215036) Geck P. … Soto A.M. (J. Steroid Biochem. Mol. Biol. 1999) 2 3 4 23 67
  2. Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. (PMID: 24141881) Carretero M. … Losada A. (EMBO J. 2013) 2 3
  3. Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells. (PMID: 19737411) Kunnev D. … Ionov Y. (BMC Cancer 2009) 3 23
  4. Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma. (PMID: 18499069) Zhang Y. … Wang M. (J Genet Genomics 2008) 3 23
  5. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. (PMID: 10963680) Geck P. … Soto A.M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23

Products for PDS5B Gene

Sources for PDS5B Gene

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