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Aliases for PDS5B Gene

Aliases for PDS5B Gene

  • PDS5 Cohesin Associated Factor B 2 3 5
  • Androgen-Induced Proliferation Inhibitor 2 3 4
  • Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS3 3 4
  • APRIN 3 4
  • AS3 3 4
  • PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae) 2
  • Sister Chromatid Cohesion Protein PDS5 Homolog B 3
  • Androgen Induced Inhibitor Of Proliferation 3
  • Androgen-Induced Shutoff 3 3
  • KIAA0979 4
  • CG008 3

External Ids for PDS5B Gene

Previous HGNC Symbols for PDS5B Gene

  • APRIN

Previous GeneCards Identifiers for PDS5B Gene

  • GC13P032059
  • GC13P033160
  • GC13P013971

Summaries for PDS5B Gene

Entrez Gene Summary for PDS5B Gene

  • This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

GeneCards Summary for PDS5B Gene

PDS5B (PDS5 Cohesin Associated Factor B) is a Protein Coding gene. Among its related pathways are Mitotic Telophase/Cytokinesis and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PDS5A.

UniProtKB/Swiss-Prot for PDS5B Gene

  • Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

Gene Wiki entry for PDS5B Gene

Additional gene information for PDS5B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDS5B Gene

Genomics for PDS5B Gene

GeneHancer (GH) Regulatory Elements for PDS5B Gene

Promoters and enhancers for PDS5B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I032585 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.4 1367 4.5 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF2 ZNF48 YY1 CBX5 ELK1 PDS5B KL ENSG00000212293 N4BP2L2 GC13M032670
GH13I032425 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 -158.4 -158356 4.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 N4BP2L1 ENSG00000212293 N4BP2L2 PDS5B ENSG00000270008 GC13M032672
GH13I032471 Enhancer 1 Ensembl ENCODE 10.3 -114.5 -114464 1.8 PKNOX1 BATF TCF12 GATA2 EGR1 EGR2 NFIL3 ATF4 NFIC SMARCA4 N4BP2L2 N4BP2L1 ENSG00000212293 PDS5B ATP8A2P2 ENSG00000270008
GH13I032837 Enhancer 1.1 FANTOM5 Ensembl ENCODE 9.3 +252.6 252623 2.5 USF1 FOXA2 NFIB RBBP5 RAD21 LCORL POLR2A ETV6 IKZF2 RUNX3 KL PDS5B ENSG00000277151 LINC00423
GH13I032650 Enhancer 0.7 ENCODE 11.9 +64.5 64502 0.2 CTCF PKNOX1 SAP130 ARID4B ZNF644 ZNF2 KMT2B RAD21 YY1 SCRT2 PDS5B KL GC13M032670
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDS5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDS5B gene promoter:

Genomic Locations for PDS5B Gene

Genomic Locations for PDS5B Gene
chr13:32,586,427-32,778,020
(GRCh38/hg38)
Size:
191,594 bases
Orientation:
Plus strand
chr13:33,160,564-33,352,158
(GRCh37/hg19)

Genomic View for PDS5B Gene

Genes around PDS5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDS5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDS5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDS5B Gene

Proteins for PDS5B Gene

  • Protein details for PDS5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTI5-PDS5B_HUMAN
    Recommended name:
    Sister chromatid cohesion protein PDS5 homolog B
    Protein Accession:
    Q9NTI5
    Secondary Accessions:
    • Q5R3S3
    • Q5W0K8
    • Q6NSC3
    • Q8IXT6
    • Q9H5N8
    • Q9Y2I5
    • Q9Y451

    Protein attributes for PDS5B Gene

    Size:
    1447 amino acids
    Molecular mass:
    164667 Da
    Quaternary structure:
    • Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable).
    SequenceCaution:
    • Sequence=BAA76823.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDS5B Gene

    Alternative splice isoforms for PDS5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDS5B Gene

Post-translational modifications for PDS5B Gene

No Post-translational modifications

No data available for DME Specific Peptides for PDS5B Gene

Domains & Families for PDS5B Gene

Gene Families for PDS5B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDS5B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NTI5

UniProtKB/Swiss-Prot:

PDS5B_HUMAN :
  • Belongs to the PDS5 family.
Family:
  • Belongs to the PDS5 family.
genes like me logo Genes that share domains with PDS5B: view

Function for PDS5B Gene

Molecular function for PDS5B Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
UniProtKB/Swiss-Prot Induction:
By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.

Phenotypes From GWAS Catalog for PDS5B Gene

Gene Ontology (GO) - Molecular Function for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 19412548
GO:0005515 protein binding IPI 15837422
GO:0005524 ATP binding TAS 10215036
genes like me logo Genes that share ontologies with PDS5B: view
genes like me logo Genes that share phenotypes with PDS5B: view

Animal Models for PDS5B Gene

MGI Knock Outs for PDS5B:

Animal Model Products

miRNA for PDS5B Gene

miRTarBase miRNAs that target PDS5B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDS5B Gene

Localization for PDS5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDS5B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDS5B gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 16682347
GO:0005634 nucleus ISS,TAS --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005694 chromosome TAS --
genes like me logo Genes that share ontologies with PDS5B: view

Pathways & Interactions for PDS5B Gene

genes like me logo Genes that share pathways with PDS5B: view

Pathways by source for PDS5B Gene

Gene Ontology (GO) - Biological Process for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IBA --
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007064 mitotic sister chromatid cohesion IMP 15855230
GO:0008283 cell proliferation TAS 10963680
genes like me logo Genes that share ontologies with PDS5B: view

No data available for SIGNOR curated interactions for PDS5B Gene

Drugs & Compounds for PDS5B Gene

No Compound Related Data Available

Transcripts for PDS5B Gene

Unigene Clusters for PDS5B Gene

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDS5B Gene

No ASD Table

Relevant External Links for PDS5B Gene

GeneLoc Exon Structure for
PDS5B
ECgene alternative splicing isoforms for
PDS5B

Expression for PDS5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDS5B Gene

Protein differential expression in normal tissues from HIPED for PDS5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Lymph node (8.5), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDS5B Gene



Protein tissue co-expression partners for PDS5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDS5B Gene:

PDS5B

SOURCE GeneReport for Unigene cluster for PDS5B Gene:

Hs.744901

mRNA Expression by UniProt/SwissProt for PDS5B Gene:

Q9NTI5-PDS5B_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PDS5B Gene

  • Blood(4.5)
  • Liver(4.4)
  • Nervous system(2.7)
  • Kidney(2.6)
  • Lung(2.6)
  • Adrenal gland(2.1)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Skin(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with PDS5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDS5B Gene

Orthologs for PDS5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDS5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDS5B 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia PDS5B 33 34
  • 95.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PDS5B 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDS5B 33 34
  • 93.9 (n)
oppossum
(Monodelphis domestica)
Mammalia PDS5B 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pds5b 33 16 34
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Pds5b 33
  • 86.44 (n)
chicken
(Gallus gallus)
Aves PDS5B 33 34
  • 84.14 (n)
lizard
(Anolis carolinensis)
Reptilia PDS5B 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pds5b 33
  • 77.58 (n)
Str.20129 33
zebrafish
(Danio rerio)
Actinopterygii pds5b 33 34
  • 72.14 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9260 33
fruit fly
(Drosophila melanogaster)
Insecta pds5 33 34
  • 48.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010643 33
  • 46.91 (n)
worm
(Caenorhabditis elegans)
Secernentea evl-14 33 34
  • 41.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25806g 33
  • 41.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDS5 33 34
  • 41.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL076W 33
  • 40.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pds5 33
  • 42.62 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00424 33
  • 40.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for PDS5B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDS5B Gene

ENSEMBL:
Gene Tree for PDS5B (if available)
TreeFam:
Gene Tree for PDS5B (if available)

Paralogs for PDS5B Gene

Paralogs for PDS5B Gene

(1) SIMAP similar genes for PDS5B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDS5B: view

Variants for PDS5B Gene

Sequence variations from dbSNP and Humsavar for PDS5B Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000056137 -- 32,647,692(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000059050 -- 32,740,889(+) T/C intron_variant
rs1000059464 -- 32,616,754(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000062325 -- 32,712,470(+) T/G intron_variant
rs1000066330 -- 32,757,807(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDS5B Gene

Variant ID Type Subtype PubMed ID
dgv1626n100 CNV loss 25217958
esv2448396 CNV deletion 19546169
esv2609555 CNV deletion 19546169
esv3305636 CNV mobile element insertion 20981092
esv3355380 CNV insertion 20981092
esv3631725 CNV loss 21293372
esv3631726 CNV loss 21293372
nsv1143587 CNV deletion 24896259
nsv507688 OTHER sequence alteration 20534489
nsv832577 CNV gain 17160897

Variation tolerance for PDS5B Gene

Residual Variation Intolerance Score: 1.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDS5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDS5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDS5B Gene

Disorders for PDS5B Gene

Additional Disease Information for PDS5B

No disorders were found for PDS5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDS5B Gene

Publications for PDS5B Gene

  1. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus. (PMID: 10215036) Geck P … Soto AM (The Journal of steroid biochemistry and molecular biology 1999) 2 3 4 22 58
  2. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. (PMID: 10963680) Geck P … Soto AM (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 58
  3. Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. (PMID: 24141881) Carretero M … Losada A (The EMBO journal 2013) 2 3 58
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 44 58
  5. Sororin mediates sister chromatid cohesion by antagonizing Wapl. (PMID: 21111234) Nishiyama T … Peters JM (Cell 2010) 3 4 58

Products for PDS5B Gene

Sources for PDS5B Gene

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