Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDS5B Gene

protein-coding   GIFtS: 54
GCID: GC13P033160

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

(Previous name: androgen-induced proliferation inhibitor )
(Previous symbol: APRIN)
 Explore 10 diseases affiliated with
PDS5B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDS5B    

Aliases
for PDS5B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae)1 2     Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS32 3
AS31 2 3 5     FLJ232361
Androgen-Induced Proliferation Inhibitor1 2 3     Androgen Induced Inhibitor Of Proliferation2
APRIN1 2 3     Androgen-Induced Shutoff 32
CG0081 2     Sister Chromatid Cohesion Protein PDS5 Homolog B2
KIAA09791 3     

External Ids:    HGNC: 204181   Entrez Gene: 230472   Ensembl: ENSG000000836427   OMIM: 6053335   UniProtKB: Q9NTI53   

Export aliases for PDS5B gene to outside databases

Previous GC identifers: GC13P032059 GC13P013971


Summaries
for PDS5B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDS5B:
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex
holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This
protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. (provided by RefSeq,
May 2010)

UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
Function: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with
chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome
partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in
androgen-induced proliferative arrest in prostate cells

Gene Wiki entry for PDS5B


Genomic Views
for PDS5B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDS5B gene promoter:
         AhR   Sox5   AP-1   p53   ATF-2   MyoD   FOXJ2 (long isoform)   Chx10   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDS5B promoter sequence
   Search SABiosciences Chromatin IP Primers for PDS5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDS5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.3   Ensembl cytogenetic band:  13q13.1   HGNC cytogenetic band: 13q12.3

PDS5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDS5B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P033160:  view genomic region     (about GC identifiers)

Start:
 33,160,564 bp from pter      End:
 33,352,158 bp from pter
Size:
 191,595 bases      Orientation:
 plus strand

Proteins
for PDS5B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5 (See protein sequence)
Recommended Name: Sister chromatid cohesion protein PDS5 homolog B  
Size: 1447 amino acids; 164667 Da
Subunit: Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via
FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA76823.2; Type=Erroneous initiation;
Secondary accessions: Q5R3S3 Q5W0K8 Q6NSC3 Q8IXT6 Q9H5N8 Q9Y2I5 Q9Y451
Alternative splicing: 5 isoforms:  Q9NTI5-1   Q9NTI5-2   Q9NTI5-3   Q9NTI5-4   Q9NTI5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDS5B: NX_Q9NTI5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NTI5

    • PDS5B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055847.1  
    ENSEMBL proteins: 
     ENSP00000313851   ENSP00000401619   ENSP00000407005  
    Reactome Protein details: Q9NTI5
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for PDS5B 
    GenScript Custom Purified and Recombinant Proteins Services for PDS5B
    Novus Biologicals PDS5B Protein
    Novus Biologicals PDS5B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PDS5B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA16682347
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--


    PDS5B for ontologies           About GeneDecksing



    PDS5B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PDS5B 
    GenScript Custom Superior Antibodies Services for PDS5B
    Novus Biologicals PDS5B Antibodies
    Search for Antibodies for PDS5B at Abcam  
    Uscn Antibodies for PDS5B
    Search ThermoFisher Antibodies for PDS5B

    Assay Products for PDS5B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDS5B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PDS5B

    Protein Domains /
    Families
    for PDS5B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDS5B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017956 AT_hook_DNA-bd_motif
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NTI5

    ProtoNet protein and cluster: Q9NTI5

    1 Blocks protein family: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
    Similarity: Belongs to the PDS5 family
    Similarity: Contains 3 A.T hook DNA-binding domains
    Similarity: Contains 1 HEAT repeat


    Function
    for PDS5B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
    Function: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with
    chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome
    partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in
    androgen-induced proliferative arrest in prostate cells
    Induction: By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels
    occur 18-20 hours after androgen exposure

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PDS5B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDS5B
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate PDS5B (see all 46):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PDS5B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDS5B (see all 7)
    OriGene shRNA RFP: PDS5B
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDS5B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDS5B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDS5B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDS5B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PDS5B (NM_015032)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDS5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDS5B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PDS5B
    Search LifeMap BioReagents cell lines for PDS5B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding TAS10215036


    PDS5B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PDS5B:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Pds5btm1Jmi for PDS5B
         14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pds5b):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging  nervous system 
     reproductive system  respiratory system  skeleton  vision/eye 

    PDS5B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDS5B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Cohesin Loading onto Chromatin
    		Cohesin Loading onto Chromatin1.00
    		Establishment of Sister Chromatid Cohesion0.62
    		Mitotic Telophase/Cytokinesis0.71
    4Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    5Ubiquitinated Orc1 is degraded by the proteasome
    		S Phase0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/14        Reactome Pathways for PDS5B (see all 14)
        Mitotic Metaphase and Anaphase
    Establishment of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase



    PDS5B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDS5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/24 Interacting proteins for PDS5B (Q9NTI51, 2, 3 ENSP000003138514) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA2P515872MINT-8384735 MINT-8392646 MINT-8384678 MINT-8384908 MINT-8384717 MINT-8392542 MINT-8384781 MINT-8384942 MINT-8392595 MINT-8384857 MINT-8384958 MINT-8385051 MINT-8392612 MINT-8384892 MINT-8385019 MINT-8384999 MINT-8385117 MINT-8385079 MINT-8384691 MINT-8391711 MINT-8392578 MINT-8384926 MINT-8385033 MINT-8392560 MINT-8385100 MINT-8392629
    SMC3Q9UQE71, 2, 3, ENSP000003547204EBI-2554539,EBI-80718 MINT-8385079 MINT-8385100 I2D: score=3 STRING: ENSP00000354720
    STAG1Q8WVM71, 3, ENSP000003726894EBI-2554539,EBI-1175097 I2D: score=3 STRING: ENSP00000372689
    RAD51Q066092MINT-8384735 MINT-8384781 MINT-8385051 MINT-8385019 MINT-8384999 MINT-8384642
    RAD21O602161, 2, 3, ENSP000002973384EBI-2554539,EBI-80739 MINT-8385079 MINT-8385100 I2D: score=3 STRING: ENSP00000297338
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007064mitotic sister chromatid cohesion IMP15855230
    GO:0008283cell proliferation TAS10963680
    GO:0008285negative regulation of cell proliferation IDA10963680
    GO:0042127regulation of cell proliferation IDA10963680
    GO:0051301cell division IEA--


    PDS5B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDS5B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDS5B
    Search CenterWatch for drugs/clinical trials and news about PDS5B 

    Transcripts
    for PDS5B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDS5B gene (2 alternative transcripts): 
    NM_015032.3  NM_015928.1  

    Unigene Cluster for PDS5B:

    PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
    Hs.646051  [show with all ESTs]
    Unigene Representative Sequence: NM_015032
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315596(uc010abf.3 uc010abg.3) ENST00000482955 ENST00000498550(uc001uuo.3 uc010teb.2)
    ENST00000450460 ENST00000493653(uc001uun.3) ENST00000466078 ENST00000481616
    ENST00000447833 ENST00000474274

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PDS5B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDS5B
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate PDS5B (see all 46):
    hsa-miR-142-5p hsa-miR-323-3p hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PDS5B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDS5B (see all 7)
    OriGene shRNA RFP: PDS5B
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDS5B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDS5B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDS5B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PDS5B (NM_015032)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDS5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDS5B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDS5B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDS5B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDS5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDS5B

    Additional cDNA sequence: 

    AB023196.2 AK128502.1 AK299340.1 AL137201.1 BC039256.1 BC070274.1 U50533.1 

    9 DOTS entries:

    DT.443135  DT.100790718  DT.100790717  DT.91813018  DT.437493  DT.40108202  DT.92021905  DT.40301743 
    DT.91667072 

    24/113 AceView cDNA sequences (see all 113):

    F12354 AI680124 CB132602 BM794657 AI636348 CA448154 AW629426 CA394375 
    NM_015032 CB129904 AB023196 AL137201 AI911784 BQ128161 CB215704 F09972 
    AA563884 BC026240 CA405800 AA333118 BG432960 AK128502 BF343183 CB268446 

    GeneLoc Exon Structure


    Expression
    for PDS5B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDS5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAATGAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PDS5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDS5B

    SOURCE GeneReport for Unigene cluster: Hs.646051

    UniProtKB/Swiss-Prot: PDS5B_HUMAN, Q9NTI5
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for PDS5B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDS5B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDS5B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDS5B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDS5B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5B

    Orthologs
    for PDS5B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDS5B gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PDS5B1 PDS5, regulator of cohesion maintenance, homolog B more 84.08(n)
    93.42(a)    		   418910  NM_001012827.2  NP_001012845.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PDS5B6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 3(183560855-183637201)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.201292 Transcribed sequence with strong similarity to protein more 81.9(n)    BX760001.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pds5b1 PDS5, regulator of cohesion maintenance, homolog B more 71.97(n)
    83.08(a)    		   565592  XM_688861.3  XP_693953.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pds51 CG17509-PA 47.99(n)
    39.62(a)    		   36286  NM_136875.3  NP_610719.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea evl-141 Protein EVL-14 42.01(n)
    25.28(a)    		   175555  NM_065464.4  NP_497865.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PDS51 Pds5p 39.92(n)
    22.25(a)    		   855099   NP_013793.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G476901 sister chromatid cohesion protein PDS5 40.82(n)
    24.43(a)    		   834820  NM_001125918.1  NP_001119390.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g02863511 hypothetical protein 42.03(n)
    25.36(a)    		   9268318  NM_001187794.1  NP_001174723.1 


    ENSEMBL Gene Tree for PDS5B (if available)
    TreeFam Gene Tree for PDS5B (if available) 

    Paralogs
    for PDS5B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDS5B gene
    PDS5A2  
    1 SIMAP similar gene for PDS5B using alignment to 2 protein entries:     PDS5B_HUMAN (see all proteins):
    PDS5A

    PDS5B for paralogs           About GeneDecksing



    Genomic Variants
    for PDS5B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3167 NCBI SNPs in PDS5B are shown (see all 3167)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs767168661,2
    		F,--13970584(+) TGGACA/GCAGGA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs755171181,2
    		C,--13970899(+) GAAACG/TTCCTT 1 -- us2k10--------
    rs770261231,2
    		F,--13971414(+) CTTTAT/ACTAAA 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs764039761,2
    		F,--13972418(+) TCGCCG/ACTCGC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs577750041,2
    		F,--13972613(+) TTAATG/ATTACT 1 -- int11Minor allele frequency- A:0.05WA 118
    rs73391241,2
    		C,F,--13973133(+) ATCGTA/CATTAC 1 -- int11Minor allele frequency- C:0.05WA 118
    rs734514041,2
    		C,--13973645(+) GTTCTC/TTTCTC 1 -- int12Minor allele frequency- T:0.07WA 120
    rs1157523641,2
    		C,F,--13975074(+) ACTTGA/CAAAAG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs95911491,2
    		--13976136(+) AAAAAT/ATTTAA 1 -- int1 trp31Minor allele frequency- A:0.50CSA 2
    rs734514101,2
    		C,--13976712(+) TCTGAC/TTCCTG 1 -- int12Minor allele frequency- T:0.10WA 120

    HapMap Linkage Disequilibrium report for PDS5B (33160564 - 33352158 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PDS5B
         2 CNVs: 101695 101696
    Locus Specific Mutation Databases (LSDB): PDS5B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDS5B
    DNA2.0 Custom Variant and Variant Library Synthesis for PDS5B

    Disorders / Diseases
    for PDS5B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDS5B for disorders           About GeneDecksing

    OMIM gene information: 605333    OMIM disorders: --

    10 diseases for PDS5B:    About MalaCards
    cornelia de lange syndrome    prostatitis    esophageal squamous cell carcinoma    squamous cell carcinoma
    embryonal carcinoma    alzheimer's disease    esophagitis    carcinoma
    prostate carcinoma    prostate cancer


    Export disorders for PDS5B gene to outside databases

    Publications
    for PDS5B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDS5B gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with PDS5B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus. (PubMed id 10215036)1, 2, 3, 9 Geck P.... Soto A.M. (1999)
    2. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. (PubMed id 10963680)1, 2, 9 Geck P.... Soto A.M. (2000)
    3. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. (PubMed id 15855230)1, 2 Losada A.... Hirano T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    6. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 3 Couch F.J.... Simard J. (1996)
    7. Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma. (PubMed id 18499069)1, 9 Zhang Y....Wang M. (2008)
    8. Par-3 partitioning defective 3 homolog (C. elegans) a nd androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells. (PubMed id 19737411)1, 9 Kunnev D....Ionov Y. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    External Searches for PDS5B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDS5B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23047 HGNC: 20418 AceView: APRIN Ensembl:ENSG00000083642 euGenes: HUgn23047
    ECgene: PDS5B H-InvDB: PDS5B

    Other Databases showing PDS5B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0979

    Specialized Databases showing PDS5B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDS5B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PDS5B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDS5B gene:
    Search GeneIP for patents involving PDS5B

    Licensable Technologies for PDS5B gene:
     Tufts University:  AS3 Expression as a Prognostic and Therapeutic Marker in Prostate Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PDS5B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PDS5B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDS5B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDS5B  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for PDS5B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDS5B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDS5B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDS5B   OriGene Custom Protein Services for PDS5B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDS5B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDS5B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDS5B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDS5B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDS5B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDS5B
     GenScript Custom Purified and Recombinant Proteins Services for PDS5B GenScript cDNA clones with any tag delivered in your preferred vector for PDS5B
     GenScript Custom Assay Services for PDS5B GenScript Custom Superior Antibodies Services for PDS5B
     GenScript Custom overexpressing Cell Line Services for PDS5B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PDS5B promoter
     Search Chromatin IP Primers for PDS5B
     RT2 qPCR Primer Assay in human, mouse, rat PDS5B
     Search GNC Networks for PDS5B
     SABiosciences Custom PCR Arrays for PDS5B
     Search Tocris compounds for PDS5B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PDS5B antibodies
     PDS5B proteins
     PDS5B lysates
     Search for Antibodies for PDS5B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PDS5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PDS5B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PDS5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5B
     SwitchGear 3'UTR luciferase reporter plasmids for PDS5B
     SwitchGear Promoter luciferase reporter plasmids for PDS5B
     Search ThermoFisher Antibodies for PDS5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDS5B
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PDS5B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4