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PDS5A Gene

protein-coding   GIFtS: 62
GCID: GC04M039824

PDS5, Regulator Of Cohesion Maintenance, Homolog A (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PDS5, Regulator Of Cohesion Maintenance, Homolog A (S. Cerevisiae)1 2     SCC1122 5
Cell Proliferation-Inducing Gene 54 Protein2 3     KIAA06483 5
Sister Chromatid Cohesion Protein 1122 3     Sister Chromatid Cohesion Protein PDS5 Homolog A2
SCC-1122 3     PDS53

External Ids:    HGNC: 290881   Entrez Gene: 232442   Ensembl: ENSG000001218927   OMIM: 6132005   UniProtKB: Q29RF73   

Export aliases for PDS5A gene to outside databases

Previous GC identifers: GC04M039501 GC04M039148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDS5A Gene:
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the
cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for PDS5A Gene:
PDS5A (PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is PDS5B.

UniProtKB/Swiss-Prot: PDS5A_HUMAN, Q29RF7
Function: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex
association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion
ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in
DNA repair

Gene Wiki entry for PDS5A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDS5A gene promoter:
         SRF   SRF (504 AA)   Nkx2-5   Pax-4a   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDS5A promoter sequence
   Search Chromatin IP Primers for PDS5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDS5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

PDS5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDS5A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M039824:  view genomic region     (about GC identifiers)

Start:
39,824,483 bp from pter      End:
39,979,576 bp from pter
Size:
155,094 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDS5A_HUMAN, Q29RF7 (See protein sequence)
Recommended Name: Sister chromatid cohesion protein PDS5 homolog A  
Size: 1337 amino acids; 150830 Da
Subunit: Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif);
the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63
Developmental stage: Cell cycle-regulated with highest level in G2 phase
Miscellaneous: HeLa cells with a reduced level of PDS5A show a mild defect in sister chromatid cohesion. HeLa
cells with a reduced level of RAD21 show reduced association of PDS5A with chromatin
Sequence caution: Sequence=AAI26226.1; Type=Erroneous initiation; Sequence=AAM82347.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=CAH18263.1; Type=Erroneous initiation;
Secondary accessions: Q2TTR5 Q68DF7 Q8N7J4 Q8NG14 Q9Y4D4
Alternative splicing: 2 isoforms:  Q29RF7-1   Q29RF7-3   

Explore the universe of human proteins at neXtProt for PDS5A: NX_Q29RF7

Explore proteomics data for PDS5A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys308, Lys366, Lys584, Lys820, Lys974, Lys1211
  • Modification sites at PhosphoSitePlus

  • See PDS5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001093869.1  NP_001093870.1  

    ENSEMBL proteins: 
     ENSP00000303427   ENSP00000424510   ENSP00000426749   ENSP00000424531   ENSP00000425386  
    Reactome Protein details: Q29RF7

    PDS5A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q29RF7

    ProtoNet protein and cluster: Q29RF7

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: PDS5A_HUMAN, Q29RF7
    Similarity: Belongs to the PDS5 family
    Similarity: Contains 1 HEAT repeat


    Find genes that share domains with PDS5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDS5A_HUMAN, Q29RF7
    Function: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex
    association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion
    ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in
    DNA repair

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15837422
         
    Find genes that share ontologies with PDS5A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDS5A:
     Increased G2M DNA content 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pds5a):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     mortality/aging  nervous system  renal/urinary system  reproductive system  respiratory system 
     skeleton  vision/eye 

    Find genes that share phenotypes with PDS5A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDS5A
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    miRNA
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    miRTarBase miRNAs that target PDS5A:
    hsa-mir-615-3p (MIRT040257), hsa-mir-130b-5p (MIRT038292), hsa-let-7b-5p (MIRT052281), hsa-mir-125b-5p (MIRT045939), hsa-mir-128-3p (MIRT045888), hsa-mir-93-3p (MIRT038836)

    Block miRNA regulation of human, mouse, rat PDS5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDS5A (see all 101):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-579 hsa-miR-300 hsa-miR-376b hsa-miR-199a-3p hsa-miR-411 hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidPDS5A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDS5A

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    Sino Biological Human cDNA Clone for PDS5A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDS5A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDS5A_HUMAN, Q29RF7: Nucleus. Note=Associated with chromatin through most of the cell cycle. Dissociates from
    chromatin in late prophase, reassociates during late telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000785chromatin IDA16682347
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome TAS--

    Find genes that share ontologies with PDS5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDS5A About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.78
    Establishment of Sister Chromatid Cohesion0.00
    5Mitotic Telophase/Cytokinesis
    Mitotic Telophase/Cytokinesis
    Cohesin Loading onto Chromatin0.00


    Find genes that share SuperPaths with PDS5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for PDS5A
        Cohesin Loading onto Chromatin
    Establishment of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDS5A
    Interactions:

        Search GeneGlobe Interaction Network for PDS5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDS5A (Q29RF71, 2, 3 ENSP000003034274) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253506 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253506 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253506 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253506 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253506 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0008156negative regulation of DNA replication IMP19907496

    Find genes that share ontologies with PDS5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDS5A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDS5A gene (3 alternative transcripts): 
    NM_001100399.1  NM_001100400.1  NM_015200.2  

    Unigene Cluster for PDS5A:

    PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
    Hs.331431  [show with all ESTs]
    Unigene Representative Sequence: NM_001100399
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303538(uc003guv.4) ENST00000507766 ENST00000507020 ENST00000503696
    ENST00000503396(uc003guw.4) ENST00000513798 ENST00000512643 ENST00000503867
    ENST00000508625 ENST00000506262
    miRNA
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    Block miRNA regulation of human, mouse, rat PDS5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDS5A (see all 101):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-579 hsa-miR-300 hsa-miR-376b hsa-miR-199a-3p hsa-miR-411 hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidPDS5A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PDS5A (NM_001100399)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDS5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDS5A
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PDS5A
      QuantiFast Probe-based Assays in human, mouse, rat PDS5A

    Additional mRNA sequence: 

    AB014548.1 AB621803.1 AF294791.1 AK001828.1 AK021757.1 AK023592.1 AK098331.1 AY550968.1 
    BC009650.1 BC041361.1 BC114218.1 BC126225.1 BC144088.1 CR749425.1 

    17 DOTS entries:

    DT.95073671  DT.117429  DT.100797391  DT.100703086  DT.210428  DT.100832007  DT.95073670  DT.95245337 
    DT.100797393  DT.95185637  DT.95217093  DT.99972532  DT.100797386  DT.100801444  DT.95176775  DT.95202476 
    DT.99988073 

    Selected AceView cDNA sequences (see all 370):

    CK430856 R89378 AA977364 AK124569 AI375886 CB160557 AI473898 AK001828 
    CA397750 BQ776220 AI825021 F12599 AA164407 AA913927 AI470853 AL705029 
    AI188372 BU631677 AI539812 CR615359 BU517176 BC009650 AI203846 BF769955 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDS5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGAATTT
    PDS5A Expression
    About this image


    PDS5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    PDS5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDS5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.331431

    UniProtKB/Swiss-Prot: PDS5A_HUMAN, Q29RF7
    Tissue specificity: Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal
    tumor tissue. Isoform 2 is expressed in kidney

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    QuantiFast Probe-based Assays in human, mouse, rat PDS5A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDS5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDS5A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pds5a1 , 5 PDS5, regulator of cohesion maintenance, homolog A more1, 5 91.69(n)1
    98.27(a)1
      5 (33.76 cM)5
    715211  NM_001081321.11  NP_001074790.11 
     656152605 
    chicken
    (Gallus gallus)
    Aves PDS5A1 PDS5, regulator of cohesion maintenance, homolog A more 84.75(n)
    93.59(a)
      422787  NM_001012580.1  NP_001012598.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDS5A6
    PDS5, regulator of cohesion maintenance, homolog A...
    91(a)
    1 ↔ 1
    5(99824833-99879226)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU914599.12   -- 77.4(n)    BU914599.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055602.12   -- 78.48(n)   393967  BC055602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pds56
    --
    36(a)
    1 → many
    2R(7915484-7921230)
    worm
    (Caenorhabditis elegans)
    Secernentea evl-146
    Protein EVL-14 (evl-14) mRNA, complete cds
    17(a)
    1 → many
    III(4302836-4313124) WBGene00001352
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PDS5(YMR076C)4 Protein required for establishment and maintenance more   --   13(420029-416196) 855099  NP_013793.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G476901 AT5G47690 41.42(n)
    26.1(a)
      834820  NM_001125918.1  NP_001119390.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02863511 Os06g0286351 41.79(n)
    26.46(a)
      9268318  NM_001187794.1  NP_001174723.1 


    ENSEMBL Gene Tree for PDS5A (if available)
    TreeFam Gene Tree for PDS5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDS5A gene
    PDS5B2  
    1 SIMAP similar gene for PDS5A using alignment to 6 protein entries:     PDS5A_HUMAN (see all proteins):
    PDS5B

    Find genes that share paralogs with PDS5A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDS5A (see all 3201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431077821,2
    C--39715474(+) TAGAC-/TAATAATA 1 -- cds10--------
    rs1831077571,2
    --39715491(+) AAAGGA/CTGCTA 1 -- ds50010--------
    rs738120091,2
    C,F--39715530(+) CTTGGC/ACAGGT 1 -- ds50012Minor allele frequency- A:0.20WA 120
    rs1385436201,2
    C--39715790(+) GTGGC-/TTTTTG 1 -- ds50010--------
    rs1879895191,2
    --39715790(+) GGTGGA/CTTTTG 1 -- ds50010--------
    rs1931422761,2
    --39716020(+) TTTTTA/TAAAAA 1 -- ut310--------
    rs1846862581,2
    --39716026(+) AAAAAA/CATTTA 1 -- ut310--------
    rs623078731,2
    C,F--39716084(+) TTATAC/TACACT 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs1160904371,2
    F--39716138(+) AAATAC/TAAGAA 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs37750781,2
    C,F,H--39716185(+) CAAATA/GTAAGT 1 -- ut31 ese319Minor allele frequency- N:0.00EA NA NS WA 3932

    HapMap Linkage Disequilibrium report for PDS5A (39824483 - 39979576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for PDS5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727471CNV Deletion23290073
    esv2667051CNV Deletion23128226
    esv2671895CNV Deletion23128226
    esv2422397CNV Duplication17116639
    nsv461338CNV Loss19166990
    esv24476CNV Loss19812545
    nsv290515CNV Loss16902084
    nsv878949CNV Loss21882294
    nsv822541CNV Gain20364138
    nsv520312CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): PDS5A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDS5A
    DNA2.0 Custom Variant and Variant Library Synthesis for PDS5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613200    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PDS5A:
    Cornelia de Lange syndrome

    Find genes that share disorders with PDS5A           About GenesLikeMe

    Genetic Association Database (GAD): PDS5A
    Human Genome Epidemiology (HuGE) Navigator: PDS5A (1 document)

    Export disorders for PDS5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDS5A gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with PDS5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. (PubMed id 15855230)1, 2, 3 Losada A.... Hirano T. (J. Cell Sci. 2005)
    2. Characterization of vertebrate cohesin complexes and their regulation in prophase. (PubMed id 11076961)1, 2, 3 Sumara I.... Peters J.-M. (J. Cell Biol. 2000)
    3. Sororin mediates sister chromatid cohesion by antagonizing wapl. (PubMed id 21111234)1, 2 Nishiyama T....Peters J.M. (Cell 2010)
    4. Cohesin acetylation speeds the replication fork. (PubMed id 19907496)1, 2 Terret M.E.... Jallepalli P.V. (Nature 2009)
    5. SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase. (PubMed id 17846787)1, 2 Zheng M.Z.... Zeng Y.X. (J. Cancer Res. Clin. Oncol. 2008)
    6. Wapl controls the dynamic association of cohesin with chromatin. (PubMed id 17113138)1, 2 Kueng S.... Peters J.M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas. (PubMed id 15019998)1, 2 Kumar D.... Kasid U. (Gene 2004)
    9. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    10. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23244 HGNC: 29088 AceView: SCC-112 Ensembl:ENSG00000121892 euGenes: HUgn23244
    ECgene: PDS5A H-InvDB: PDS5A

    (According to HUGE)
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    HUGE: KIAA0648

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDS5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDS5A gene:
    Search GeneIP for patents involving PDS5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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