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Aliases for PDRG1 Gene

Aliases for PDRG1 Gene

  • P53 And DNA-Damage Regulated 1 2 3
  • C20orf126 3 4 6
  • PDRG 3 4 6
  • P53 And DNA Damage-Regulated Protein 1 3
  • Chromosome 20 Open Reading Frame 126 2
  • P53 And DNA Damage Regulated 1 3

External Ids for PDRG1 Gene

Previous HGNC Symbols for PDRG1 Gene

  • C20orf126

Previous GeneCards Identifiers for PDRG1 Gene

  • GC20M029996
  • GC20M030532
  • GC20M027321

Summaries for PDRG1 Gene

GeneCards Summary for PDRG1 Gene

PDRG1 (P53 And DNA-Damage Regulated 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for PDRG1 Gene

  • May play a role in chaperone-mediated protein folding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDRG1 Gene

Genomics for PDRG1 Gene

Regulatory Elements for PDRG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDRG1 Gene

Start:
31,944,342 bp from pter
End:
31,968,710 bp from pter
Size:
24,369 bases
Orientation:
Minus strand

Genomic View for PDRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDRG1 Gene

Proteins for PDRG1 Gene

  • Protein details for PDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUG6-PDRG1_HUMAN
    Recommended name:
    p53 and DNA damage-regulated protein 1
    Protein Accession:
    Q9NUG6
    Secondary Accessions:
    • B2R511
    • Q96GP3
    • Q9BUW8

    Protein attributes for PDRG1 Gene

    Size:
    133 amino acids
    Molecular mass:
    15511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDRG1 Gene

Proteomics data for PDRG1 Gene at MOPED

Post-translational modifications for PDRG1 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for PDRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDRG1 Gene

Domains for PDRG1 Gene

Protein Domains for PDRG1 Gene

Suggested Antigen Peptide Sequences for PDRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUG6

UniProtKB/Swiss-Prot:

PDRG1_HUMAN :
  • Q9NUG6
Family:
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PDRG1: view

No data available for Gene Families for PDRG1 Gene

Function for PDRG1 Gene

Molecular function for PDRG1 Gene

UniProtKB/Swiss-Prot Function: May play a role in chaperone-mediated protein folding.
UniProtKB/Swiss-Prot Induction: By UV irradiation and repressed by p53/TP53.

Gene Ontology (GO) - Molecular Function for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PDRG1 Gene

Localization for PDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDRG1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDRG1 Gene COMPARTMENTS Subcellular localization image for PDRG1 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016272 prefoldin complex IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Pathways for PDRG1 Gene

SuperPathways for PDRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

No data available for Pathways by source for PDRG1 Gene

Transcripts for PDRG1 Gene

mRNA/cDNA for PDRG1 Gene

(244) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDRG1 Gene

P53 and DNA-damage regulated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDRG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -
SP3:

Relevant External Links for PDRG1 Gene

GeneLoc Exon Structure for
PDRG1
ECgene alternative splicing isoforms for
PDRG1

Expression for PDRG1 Gene

mRNA expression in normal human tissues for PDRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDRG1 Gene

SOURCE GeneReport for Unigene cluster for PDRG1 Gene Hs.435755

mRNA Expression by UniProt/SwissProt for PDRG1 Gene

Q9NUG6-PDRG1_HUMAN
Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.
genes like me logo Genes that share expressions with PDRG1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PDRG1 Gene

Orthologs for PDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDRG1 35
  • 99.25 (n)
  • 99.25 (a)
PDRG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDRG1 35
  • 92.48 (n)
  • 95.49 (a)
PDRG1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDRG1 35
  • 91.73 (n)
  • 96.99 (a)
PDRG1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdrg1 35
  • 88.22 (n)
  • 91.73 (a)
Pdrg1 16
Pdrg1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDRG1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDRG1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdrg1 35
  • 86.47 (n)
  • 89.47 (a)
chicken
(Gallus gallus)
Aves PDRG1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDRG1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdrg1 35
  • 63.73 (n)
  • 62.4 (a)
zebrafish
(Danio rerio)
Actinopterygii pdrg1 35
  • 59.52 (n)
  • 61.11 (a)
pdrg1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15863 36
  • 27 (a)
OneToOne
Species with no ortholog for PDRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDRG1 Gene

ENSEMBL:
Gene Tree for PDRG1 (if available)
TreeFam:
Gene Tree for PDRG1 (if available)

Paralogs for PDRG1 Gene

Pseudogenes.org Pseudogenes for PDRG1 Gene

genes like me logo Genes that share paralogs with PDRG1: view

No data available for Paralogs for PDRG1 Gene

Variants for PDRG1 Gene

Sequence variations from dbSNP and Humsavar for PDRG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2328 -- 31,965,674(+) tctca(C/T)tttac intron-variant
rs745384 -- 31,952,914(+) TGTCC(A/G)GAGTA upstream-variant-2KB, intron-variant
rs1883507 -- 31,953,640(+) TAGCC(A/T)TTGGC upstream-variant-2KB, intron-variant
rs1883508 -- 31,953,891(+) TCCTC(C/T)ACCTT upstream-variant-2KB, intron-variant
rs2143209 -- 31,950,103(+) ACCTG(A/T)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDRG1 Gene

Variant ID Type Subtype PubMed ID
nsv833952 CNV Gain 17160897

Relevant External Links for PDRG1 Gene

HapMap Linkage Disequilibrium report
PDRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDRG1 Gene

Disorders for PDRG1 Gene

Relevant External Links for PDRG1

Genetic Association Database (GAD)
PDRG1
genes like me logo Genes that share disorders with PDRG1: view

No data available for UniProtKB/Swiss-Prot for PDRG1 Gene

Publications for PDRG1 Gene

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PMID: 14562055) Luo X. … Sheikh M.S. (Oncogene 2003) 2 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. (PMID: 19450687) Cloutier P. … Coulombe B. (Methods 2009) 3

Products for PDRG1 Gene

Sources for PDRG1 Gene

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