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Aliases for PDRG1 Gene

Aliases for PDRG1 Gene

  • P53 And DNA Damage Regulated 1 2 3 5
  • C20orf126 3 4
  • PDRG 3 4
  • P53 And DNA Damage-Regulated Protein 1 3
  • Chromosome 20 Open Reading Frame 126 2
  • P53 And DNA-Damage Regulated 1 2

External Ids for PDRG1 Gene

Previous HGNC Symbols for PDRG1 Gene

  • C20orf126

Previous GeneCards Identifiers for PDRG1 Gene

  • GC20M029996
  • GC20M030532
  • GC20M027321

Summaries for PDRG1 Gene

GeneCards Summary for PDRG1 Gene

PDRG1 (P53 And DNA Damage Regulated 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for PDRG1 Gene

  • May play a role in chaperone-mediated protein folding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDRG1 Gene

Genomics for PDRG1 Gene

Regulatory Elements for PDRG1 Gene

Enhancers for PDRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F031709 1.4 FANTOM5 Ensembl ENCODE 9.8 +251.5 251522 14.7 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 MYLK2 COX4I2 DEFB121 RNU1-94P DEFB122 DEFB123 DEFB118 REM1 LOC105372589 ID1
GH20F031661 1.3 FANTOM5 Ensembl ENCODE 9.8 +302.2 302240 10.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 DEFB123 RNU1-94P DEFB122 DEFB121 DEFB118 PDRG1 HM13 COX4I2 TTLL9 MYLK2
GH20F032559 0.7 Ensembl ENCODE 9.8 -592.6 -592554 3.7 PKNOX1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 KLF7 SP3 SP5 SUN5 BPIFB5P BPIFA3 ENSG00000224876 RPL12P3 RNU1-94P PDRG1 MYLK2 LOC149950 LOC105372591
GH20F031513 0.7 FANTOM5 ENCODE 9.8 +452.7 452728 4.3 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 HM13 DEFB124 DEFB123 DEFB122 DEFB121 DEFB118 RNU1-94P REM1 PDRG1 ENSG00000274364
GH20F031968 0.6 ENCODE 0.8 +0.2 158 0.2 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 KLF13 DEK C20orf203 TSPY26P RSL24D1P6 KIF3B FOXS1 PDRG1 XKR7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PDRG1 on UCSC Golden Path with GeneCards custom track

Promoters for PDRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001836666 510 1201 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 KLF13 DEK

Genomic Location for PDRG1 Gene

Chromosome:
20
Start:
31,944,342 bp from pter
End:
31,968,710 bp from pter
Size:
24,369 bases
Orientation:
Minus strand

Genomic View for PDRG1 Gene

Genes around PDRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDRG1 Gene

Proteins for PDRG1 Gene

  • Protein details for PDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUG6-PDRG1_HUMAN
    Recommended name:
    p53 and DNA damage-regulated protein 1
    Protein Accession:
    Q9NUG6
    Secondary Accessions:
    • B2R511
    • Q96GP3
    • Q9BUW8

    Protein attributes for PDRG1 Gene

    Size:
    133 amino acids
    Molecular mass:
    15511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDRG1 Gene

Post-translational modifications for PDRG1 Gene

  • Ubiquitination at Lys 27
  • Modification sites at PhosphoSitePlus

Other Protein References for PDRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PDRG1
  • Santa Cruz Biotechnology (SCBT) Antibodies for PDRG1

No data available for DME Specific Peptides for PDRG1 Gene

Domains & Families for PDRG1 Gene

Protein Domains for PDRG1 Gene

Suggested Antigen Peptide Sequences for PDRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUG6

UniProtKB/Swiss-Prot:

PDRG1_HUMAN :
  • Belongs to the prefoldin subunit beta family.
Family:
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PDRG1: view

No data available for Gene Families for PDRG1 Gene

Function for PDRG1 Gene

Molecular function for PDRG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chaperone-mediated protein folding.
UniProtKB/Swiss-Prot Induction:
By UV irradiation and repressed by p53/TP53.

Gene Ontology (GO) - Molecular Function for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Phenotypes for PDRG1 Gene

GenomeRNAi human phenotypes for PDRG1:
genes like me logo Genes that share phenotypes with PDRG1: view

Animal Model Products

miRNA for PDRG1 Gene

miRTarBase miRNAs that target PDRG1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDRG1 Gene

Localization for PDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDRG1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDRG1 Gene COMPARTMENTS Subcellular localization image for PDRG1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016272 prefoldin complex IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Pathways & Interactions for PDRG1 Gene

SuperPathways for PDRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

No data available for Pathways by source and SIGNOR curated interactions for PDRG1 Gene

Transcripts for PDRG1 Gene

mRNA/cDNA for PDRG1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(244) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDRG1 Gene

P53 and DNA-damage regulated 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -
SP3:

Relevant External Links for PDRG1 Gene

GeneLoc Exon Structure for
PDRG1
ECgene alternative splicing isoforms for
PDRG1

Expression for PDRG1 Gene

mRNA expression in normal human tissues for PDRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDRG1 Gene

This gene is overexpressed in Bone marrow stromal cell (25.2) and Peripheral blood mononuclear cells (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDRG1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PDRG1 Gene:

PDRG1

SOURCE GeneReport for Unigene cluster for PDRG1 Gene:

Hs.435755

mRNA Expression by UniProt/SwissProt for PDRG1 Gene:

Q9NUG6-PDRG1_HUMAN
Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.
genes like me logo Genes that share expression patterns with PDRG1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PDRG1 Gene

Orthologs for PDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDRG1 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia PDRG1 34 35
  • 92.48 (n)
dog
(Canis familiaris)
Mammalia PDRG1 34 35
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Pdrg1 34 16 35
  • 88.22 (n)
rat
(Rattus norvegicus)
Mammalia Pdrg1 34
  • 86.47 (n)
oppossum
(Monodelphis domestica)
Mammalia PDRG1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDRG1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDRG1 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDRG1 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdrg1 34
  • 63.73 (n)
zebrafish
(Danio rerio)
Actinopterygii pdrg1 34 35
  • 59.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15863 35
  • 27 (a)
OneToOne
Species where no ortholog for PDRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDRG1 Gene

ENSEMBL:
Gene Tree for PDRG1 (if available)
TreeFam:
Gene Tree for PDRG1 (if available)

Paralogs for PDRG1 Gene

Pseudogenes.org Pseudogenes for PDRG1 Gene

genes like me logo Genes that share paralogs with PDRG1: view

No data available for Paralogs for PDRG1 Gene

Variants for PDRG1 Gene

Sequence variations from dbSNP and Humsavar for PDRG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111382388 -- 31,946,480(+) CAGTC(C/T)CTGCT intron-variant
rs111468492 -- 31,948,487(+) AAAAG(A/C)AGCAT intron-variant
rs111829529 -- 31,947,181(+) ACCAA(C/G/T)TGACT intron-variant
rs112091436 -- 31,952,593(+) GCCAA(A/G)GCGGG upstream-variant-2KB
rs112112829 -- 31,949,014(+) TACAG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDRG1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
nsv833952 CNV gain 17160897

Variation tolerance for PDRG1 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDRG1 Gene

Disorders for PDRG1 Gene

Relevant External Links for PDRG1

Genetic Association Database (GAD)
PDRG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDRG1

No disorders were found for PDRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDRG1 Gene

Publications for PDRG1 Gene

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PMID: 14562055) Luo X. … Sheikh M.S. (Oncogene 2003) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. (PMID: 25706919) Wang J. … Wang C. (PLoS ONE 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PDRG1 Gene

Sources for PDRG1 Gene

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