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Aliases for PDRG1 Gene

Aliases for PDRG1 Gene

  • P53 And DNA Damage Regulated 1 2 3 5
  • C20orf126 3 4
  • PDRG 3 4
  • P53 And DNA Damage-Regulated Protein 1 3
  • Chromosome 20 Open Reading Frame 126 2
  • P53 And DNA-Damage Regulated 1 2

External Ids for PDRG1 Gene

Previous HGNC Symbols for PDRG1 Gene

  • C20orf126

Previous GeneCards Identifiers for PDRG1 Gene

  • GC20M029996
  • GC20M030532
  • GC20M027321

Summaries for PDRG1 Gene

GeneCards Summary for PDRG1 Gene

PDRG1 (P53 And DNA Damage Regulated 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for PDRG1 Gene

  • May play a role in chaperone-mediated protein folding.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDRG1 Gene

Genomics for PDRG1 Gene

Regulatory Elements for PDRG1 Gene

Enhancers for PDRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G031601 2.3 VISTA FANTOM5 ENCODE dbSUPER 10.3 +361.3 361259 11.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MYLK2 COX4I2 TSPY26P HM13 RNU6-384P HM13-AS1 MCTS2P PDRG1 ID1 LOC149935
GH20G031590 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +373.9 373862 8.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 TSPY26P HM13 PLAGL2 MCTS2P PDRG1 COX4I2 ID1 LOC105372588 RNU6-384P
GH20G031894 1.5 FANTOM5 Ensembl ENCODE 10.5 +73.4 73377 1.5 HDGF ATF1 ZNF493 ZFP64 ZNF133 RFX5 ZNF302 ZNF354C ZNF143 IKZF2 TSPY26P PDRG1 REM1 C20orf203 DUSP15 MYLK2 RNU1-94P
GH20G031818 1.2 Ensembl ENCODE dbSUPER 10.4 +148.9 148882 2.1 KLF1 ZFP64 ZNF140 ZNF697 ZFHX2 SCRT2 EGR2 SCRT1 ZBTB11 ZBTB8A MYLK2 TSPY26P PDRG1 C20orf203 GC20M031845
GH20G031987 1 dbSUPER 11.4 -21.8 -21765 6.2 ATF1 FOXA2 CREB3L1 ARID4B SIN3A ZNF2 GLIS2 ELK1 FOS SP3 TTLL9 DUSP15 MYLK2 ENSG00000226239 XKR7 PDRG1 TM9SF4 CCM2L GC20P031999 ENSG00000278012
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDRG1 on UCSC Golden Path with GeneCards custom track

Promoters for PDRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136071 510 401 ATF1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ELK1 ZNF143

Genomic Location for PDRG1 Gene

31,944,342 bp from pter
31,968,710 bp from pter
24,369 bases
Minus strand

Genomic View for PDRG1 Gene

Genes around PDRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDRG1 Gene

Proteins for PDRG1 Gene

  • Protein details for PDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    p53 and DNA damage-regulated protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R511
    • Q96GP3
    • Q9BUW8

    Protein attributes for PDRG1 Gene

    133 amino acids
    Molecular mass:
    15511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDRG1 Gene

Post-translational modifications for PDRG1 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for PDRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDRG1 Gene

Domains & Families for PDRG1 Gene

Protein Domains for PDRG1 Gene

Suggested Antigen Peptide Sequences for PDRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the prefoldin subunit beta family.
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PDRG1: view

No data available for Gene Families for PDRG1 Gene

Function for PDRG1 Gene

Molecular function for PDRG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chaperone-mediated protein folding.
UniProtKB/Swiss-Prot Induction:
By UV irradiation and repressed by p53/TP53.

Gene Ontology (GO) - Molecular Function for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Phenotypes for PDRG1 Gene

GenomeRNAi human phenotypes for PDRG1:
genes like me logo Genes that share phenotypes with PDRG1: view

Animal Model Products

CRISPR Products

miRNA for PDRG1 Gene

miRTarBase miRNAs that target PDRG1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDRG1 Gene

Localization for PDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDRG1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDRG1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016272 prefoldin complex IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Pathways & Interactions for PDRG1 Gene

SuperPathways for PDRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PDRG1: view

No data available for Pathways by source and SIGNOR curated interactions for PDRG1 Gene

Drugs & Compounds for PDRG1 Gene

No Compound Related Data Available

Transcripts for PDRG1 Gene

mRNA/cDNA for PDRG1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(244) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDRG1 Gene

P53 and DNA-damage regulated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -

Relevant External Links for PDRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDRG1 Gene

This gene is overexpressed in Bone marrow stromal cell (25.2) and Peripheral blood mononuclear cells (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDRG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDRG1 Gene:


SOURCE GeneReport for Unigene cluster for PDRG1 Gene:


mRNA Expression by UniProt/SwissProt for PDRG1 Gene:

Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.

Evidence on tissue expression from TISSUES for PDRG1 Gene

  • Nervous system(4.5)
  • Muscle(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with PDRG1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDRG1 Gene

Orthologs for PDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDRG1 34 35
  • 99.25 (n)
(Bos Taurus)
Mammalia PDRG1 34 35
  • 92.48 (n)
(Canis familiaris)
Mammalia PDRG1 34 35
  • 91.73 (n)
(Mus musculus)
Mammalia Pdrg1 34 16 35
  • 88.22 (n)
(Rattus norvegicus)
Mammalia Pdrg1 34
  • 86.47 (n)
(Monodelphis domestica)
Mammalia PDRG1 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PDRG1 35
  • 63 (a)
(Gallus gallus)
Aves PDRG1 35
  • 51 (a)
(Anolis carolinensis)
Reptilia PDRG1 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdrg1 34
  • 63.73 (n)
(Danio rerio)
Actinopterygii pdrg1 34 35
  • 59.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15863 35
  • 27 (a)
Species where no ortholog for PDRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDRG1 Gene

Gene Tree for PDRG1 (if available)
Gene Tree for PDRG1 (if available)

Paralogs for PDRG1 Gene Pseudogenes for PDRG1 Gene

genes like me logo Genes that share paralogs with PDRG1: view

No data available for Paralogs for PDRG1 Gene

Variants for PDRG1 Gene

Sequence variations from dbSNP and Humsavar for PDRG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000030839 -- 31,952,053(+) CTTCC(A/G)GCGCG utr-variant-5-prime
rs1000175146 -- 31,947,896(+) AGGAA(A/G)AAAAA intron-variant
rs1000200999 -- 31,953,150(+) CTTTG(A/C)AAAGA upstream-variant-2KB
rs1000360235 -- 31,949,605(+) AGAAC(A/G)GCAAG intron-variant
rs1000458580 -- 31,947,640(+) ATCCC(A/C)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDRG1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
nsv833952 CNV gain 17160897

Variation tolerance for PDRG1 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDRG1 Gene

Disorders for PDRG1 Gene

Relevant External Links for PDRG1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PDRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDRG1 Gene

Publications for PDRG1 Gene

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PMID: 14562055) Luo X. … Sheikh M.S. (Oncogene 2003) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway. (PMID: 27610824) Tao Z. … Ma H. (Biomed. Pharmacother. 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PDRG1 Gene

Sources for PDRG1 Gene

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