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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDRG1 Gene

protein-coding   GIFtS: 50
GCID: GC20M030532

P53 And DNA-Damage Regulated 1

(Previous name: chromosome 20 open reading frame 126)
(Previous symbol: C20orf126)
  Search for PDRG1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
P53 And DNA-Damage Regulated 11 2
C20orf1261 2 3 5
PDRG2 3 5
Chromosome 20 Open Reading Frame 1261
P53 And DNA Damage Regulated 12
P53 And DNA Damage-Regulated Protein 12

External Ids:    HGNC: 161191   Entrez Gene: 815722   Ensembl: ENSG000000883567   OMIM: 6107895   UniProtKB: Q9NUG63   

Export aliases for PDRG1 gene to outside databases

Previous GC identifers: GC20M029996 GC20M027321


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PDRG1 Gene: 
PDRG1 (p53 and DNA-damage regulated 1) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: PDRG1_HUMAN, Q9NUG6
Function: May play a role in chaperone-mediated protein folding (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDRG1 gene promoter:
         Max1   Elk-1   NRSF form 1   NRSF form 2   Evi-1   GATA-1   FOXC1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDRG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDRG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

PDRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDRG1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030532:  view genomic region     (about GC identifiers)

Start:
30,532,758 bp from pter      End:
30,539,895 bp from pter
Size:
7,138 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDRG1_HUMAN, Q9NUG6 (See protein sequence)
Recommended Name: p53 and DNA damage-regulated protein 1  
Size: 133 amino acids; 15511 Da
Subcellular location: Cytoplasm (Potential)
Secondary accessions: B2R511 Q96GP3 Q9BUW8

Explore the universe of human proteins at neXtProt for PDRG1: NX_Q9NUG6

Explore proteomics data for PDRG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NUG6

  • PDRG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDRG1 Protein Expression
    REFSEQ proteins: NP_110442.1  
    ENSEMBL proteins: 
     ENSP00000202017  

    Human Recombinant Protein Products for PDRG1: 
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    Sino Biological Recombinant Protein for PDRG1
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    ProSpec Recombinant Protein for PDRG1
    Cloud-Clone Corp. Proteins for PDRG1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016272prefoldin complex IEA--

    PDRG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002777 PFD_beta-like

    Graphical View of Domain Structure for InterPro Entry Q9NUG6

    ProtoNet protein and cluster: Q9NUG6

    1 Blocks protein domain: IPB002777 Prefoldin-related KE2 protein

    UniProtKB/Swiss-Prot: PDRG1_HUMAN, Q9NUG6
    Similarity: Belongs to the prefoldin subunit beta family


    PDRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDRG1_HUMAN, Q9NUG6
    Function: May play a role in chaperone-mediated protein folding (Potential)
    Induction: By UV irradiation and repressed by p53/TP53

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051082unfolded protein binding IEA--
         
    PDRG1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidPDRG1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for PDRG1 (Q9NUG62, 3 ENSP000002020174) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-47990 MINT-48446 I2D: score=3 
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    RPAP2Q8IXW53, ENSP000003593684I2D: score=1 STRING: ENSP00000359368
    RPAP3Q9H6T33, ENSP000000053864I2D: score=1 STRING: ENSP00000005386
    PARD6AQ9NPB63, ENSP000002192554I2D: score=2 STRING: ENSP00000219255
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--

    PDRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDRG1

    Search CenterWatch for drugs/clinical trials and news about PDRG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDRG1 gene: 
    NM_030815.2  

    Unigene Cluster for PDRG1:

    P53 and DNA-damage regulated 1
    Hs.435755  [show with all ESTs]
    Unigene Representative Sequence: BM913118
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000202017(uc002wxd.3)
    miRNA
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    hsa-miR-3673 hsa-miR-206 hsa-miR-550a hsa-miR-324-3p hsa-miR-519e hsa-miR-1 hsa-miR-664 hsa-miR-1233
    SwitchGear 3'UTR luciferase reporter plasmidPDRG1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDRG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDRG1

    Additional mRNA sequence: 

    AK312021.1 AY286301.1 BC001856.2 BC009334.2 

    7 DOTS entries:

    DT.316048  DT.100808263  DT.70104561  DT.91749419  DT.91790478  DT.91791682  DT.95300039 

    24/244 AceView cDNA sequences (see all 244):

    NM_030815 CD365168 BM820256 CD366729 T30924 BQ014210 BU739066 AA326798 
    BU625350 BU174915 BU170147 AW327551 BC009334 CA447881 BQ632414 BM458675 
    AI935800 CA425238 BU625346 CD369871 AW337749 BI333285 AW007607 CA748661 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -           -                     
    SP2:                          -           -                     
    SP3:                                                            


    ECgene alternative splicing isoforms for PDRG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDRG1 expression in normal human tissues (normalized intensities)      PDRG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGTTGCT
    PDRG1 Expression
    About this image


    PDRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node

    See PDRG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDRG1

    SOURCE GeneReport for Unigene cluster: Hs.435755

    UniProtKB/Swiss-Prot: PDRG1_HUMAN, Q9NUG6
    Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in
    other organs

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDRG1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdrg11 , 5 p53 and DNA damage regulated 11, 5 88.22(n)1
    91.73(a)1
      2 (75.41 cM)5
    685591  NM_178939.21  NP_849270.11 
     1530088905 
    chicken
    (Gallus gallus)
    Aves PDRG11 p53 and DNA-damage regulated 1 65.26(n)
    61.05(a)
      771852  XM_001235075.2  XP_001235076.2 
    lizard
    (Anolis carolinensis)
    Reptilia PDRG16
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343505.1(83082-95637)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1125191 zgc:112519 57.95(n)
    59.23(a)
      550453  NM_001017757.1  NP_001017757.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG158636
    --
    27(a)
    1 ↔ 1
    2R(5846624-5847206)


    ENSEMBL Gene Tree for PDRG1 (if available)
    TreeFam Gene Tree for PDRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDRG1 gene

    PDRG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PDRG1
    PGOHUM00000239878


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/255 SNPs in PDRG1 are shown (see all 255)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881874971,2
    --30532259(+) CACCTA/GTGCGC 1 -- ds50010--------
    rs1931750771,2
    --30532294(+) AGGGAA/CTCACA 1 -- ds50010--------
    rs1854181891,2
    --30532298(+) AATCAA/CACTGT 1 -- ds50010--------
    rs1889837451,2
    --30532313(+) GCACAA/GAAATT 1 -- ds50010--------
    rs1926000381,2
    --30532444(+) CCACAC/TTCATG 1 -- ds50010--------
    rs1143502161,2
    F--30532448(+) ACTCAT/CGTTTT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1149869281,2
    C,F--30532487(+) TAAAAG/AGAGAT 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs60610461,2
    C,F,A,H--30532709(+) TGGAGT/CGGCGT 1 -- ds500135Minor allele frequency- C:0.46NS EA NA WA CSA 3163
    rs1399246711,2
    --30532712(+) AGTGGC/TGTGCC 1 -- ds50010--------
    rs61212901,2
    C,H--30532753(+) GACTAG/TTTGCT 1 -- ds50014Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for PDRG1 (30532758 - 30539895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PDRG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833952CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PDRG1 for disorders           About MalaCards
    OMIM gene information: 610789    OMIM disorders: --


    PDRG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PDRG1

    Export disorders for PDRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDRG1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PDRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PubMed id 14562055)1, 2, 3, 9 Luo X.... Sheikh M.S. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. (PubMed id 21360678)1 Skarra D.V....Honkanen R.E. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress. (PubMed id 21193842)1 Jiang L....Huang Y. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81572 HGNC: 16119 AceView: PDRG1 Ensembl:ENSG00000088356 euGenes: HUgn81572
    ECgene: PDRG1 H-InvDB: PDRG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDRG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDRG1 gene:
    Search GeneIP for patents involving PDRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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