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Aliases for PDRG1 Gene

Aliases for PDRG1 Gene

  • P53 And DNA Damage Regulated 1 2 3 5
  • P53 And DNA-Damage Regulated 1 2 3
  • C20orf126 3 4
  • PDRG 3 4
  • Chromosome 20 Open Reading Frame 126 2

External Ids for PDRG1 Gene

Previous HGNC Symbols for PDRG1 Gene

  • C20orf126

Previous GeneCards Identifiers for PDRG1 Gene

  • GC20M029996
  • GC20M030532
  • GC20M027321

Summaries for PDRG1 Gene

GeneCards Summary for PDRG1 Gene

PDRG1 (P53 And DNA Damage Regulated 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for PDRG1 Gene

  • May play a role in chaperone-mediated protein folding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDRG1 Gene

Genomics for PDRG1 Gene

Regulatory Elements for PDRG1 Gene

Enhancers for PDRG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDRG1 on UCSC Golden Path with GeneCards custom track

Promoters for PDRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDRG1 Gene

31,944,342 bp from pter
31,968,710 bp from pter
24,369 bases
Minus strand

Genomic View for PDRG1 Gene

Genes around PDRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDRG1 Gene

Proteins for PDRG1 Gene

  • Protein details for PDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    p53 and DNA damage-regulated protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R511
    • Q96GP3
    • Q9BUW8

    Protein attributes for PDRG1 Gene

    133 amino acids
    Molecular mass:
    15511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDRG1 Gene

Proteomics data for PDRG1 Gene at MOPED

Post-translational modifications for PDRG1 Gene

  • Ubiquitination at Lys 27
  • Modification sites at PhosphoSitePlus

Other Protein References for PDRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PDRG1

No data available for DME Specific Peptides for PDRG1 Gene

Domains & Families for PDRG1 Gene

Protein Domains for PDRG1 Gene

Suggested Antigen Peptide Sequences for PDRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the prefoldin subunit beta family.
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PDRG1: view

No data available for Gene Families for PDRG1 Gene

Function for PDRG1 Gene

Molecular function for PDRG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chaperone-mediated protein folding.
UniProtKB/Swiss-Prot Induction:
By UV irradiation and repressed by p53/TP53.

Phenotypes for PDRG1 Gene

GenomeRNAi human phenotypes for PDRG1:
genes like me logo Genes that share phenotypes with PDRG1: view

Animal Model Products

CRISPR Products

miRNA for PDRG1 Gene

miRTarBase miRNAs that target PDRG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDRG1 Gene

Localization for PDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDRG1 Gene


Subcellular locations from

Jensen Localization Image for PDRG1 Gene COMPARTMENTS Subcellular localization image for PDRG1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Pathways & Interactions for PDRG1 Gene

SuperPathways for PDRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDRG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PDRG1 Gene

Drugs & Compounds for PDRG1 Gene

No Compound Related Data Available

Transcripts for PDRG1 Gene

mRNA/cDNA for PDRG1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(244) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDRG1 Gene

P53 and DNA-damage regulated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -

Relevant External Links for PDRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDRG1 Gene

mRNA expression in normal human tissues for PDRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDRG1 Gene

This gene is overexpressed in Bone marrow stromal cell (25.2) and Peripheral blood mononuclear cells (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDRG1 Gene

SOURCE GeneReport for Unigene cluster for PDRG1 Gene Hs.435755

mRNA Expression by UniProt/SwissProt for PDRG1 Gene

Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.
genes like me logo Genes that share expression patterns with PDRG1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PDRG1 Gene

Orthologs for PDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDRG1 35
  • 92.48 (n)
  • 95.49 (a)
PDRG1 36
  • 95 (a)
(Canis familiaris)
Mammalia PDRG1 35
  • 91.73 (n)
  • 96.99 (a)
PDRG1 36
  • 97 (a)
(Mus musculus)
Mammalia Pdrg1 35
  • 88.22 (n)
  • 91.73 (a)
Pdrg1 16
Pdrg1 36
  • 92 (a)
(Pan troglodytes)
Mammalia PDRG1 35
  • 99.25 (n)
  • 99.25 (a)
PDRG1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pdrg1 35
  • 86.47 (n)
  • 89.47 (a)
(Monodelphis domestica)
Mammalia PDRG1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PDRG1 36
  • 63 (a)
(Gallus gallus)
Aves PDRG1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia PDRG1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdrg1 35
  • 63.73 (n)
  • 62.4 (a)
(Danio rerio)
Actinopterygii pdrg1 35
  • 59.52 (n)
  • 61.11 (a)
pdrg1 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15863 36
  • 27 (a)
Species with no ortholog for PDRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDRG1 Gene

Gene Tree for PDRG1 (if available)
Gene Tree for PDRG1 (if available)

Paralogs for PDRG1 Gene Pseudogenes for PDRG1 Gene

genes like me logo Genes that share paralogs with PDRG1: view

No data available for Paralogs for PDRG1 Gene

Variants for PDRG1 Gene

Sequence variations from dbSNP and Humsavar for PDRG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2328 -- 31,965,674(+) tctca(C/T)tttac intron-variant
rs745384 -- 31,952,914(+) TGTCC(A/G)GAGTA intron-variant, upstream-variant-2KB
rs1883507 -- 31,953,640(+) TAGCC(A/T)TTGGC intron-variant, upstream-variant-2KB
rs1883508 -- 31,953,891(+) TCCTC(C/T)ACCTT intron-variant, upstream-variant-2KB
rs2143209 -- 31,950,103(+) ACCTG(A/T)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDRG1 Gene

Variant ID Type Subtype PubMed ID
nsv833952 CNV Gain 17160897

Variation tolerance for PDRG1 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PDRG1 Gene

Disorders for PDRG1 Gene

Relevant External Links for PDRG1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PDRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDRG1 Gene

Publications for PDRG1 Gene

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PMID: 14562055) Luo X. … Sheikh M.S. (Oncogene 2003) 2 3 4 23 67
  2. MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer. (PMID: 25706919) Wang J. … Wang C. (PLoS ONE 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PDRG1 Gene

Sources for PDRG1 Gene