Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDRG1 Gene

Aliases for PDRG1 Gene

  • P53 And DNA Damage Regulated 1 2 3 5
  • P53 And DNA-Damage Regulated 1 2 3
  • C20orf126 3 4
  • PDRG 3 4
  • Chromosome 20 Open Reading Frame 126 2

External Ids for PDRG1 Gene

Previous HGNC Symbols for PDRG1 Gene

  • C20orf126

Previous GeneCards Identifiers for PDRG1 Gene

  • GC20M029996
  • GC20M030532
  • GC20M027321

Summaries for PDRG1 Gene

GeneCards Summary for PDRG1 Gene

PDRG1 (P53 And DNA Damage Regulated 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for PDRG1 Gene

  • May play a role in chaperone-mediated protein folding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDRG1 Gene

Genomics for PDRG1 Gene

Regulatory Elements for PDRG1 Gene

Promoters for PDRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDRG1 Gene

Chromosome:
20
Start:
31,944,342 bp from pter
End:
31,968,710 bp from pter
Size:
24,369 bases
Orientation:
Minus strand

Genomic View for PDRG1 Gene

Genes around PDRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDRG1 Gene

Proteins for PDRG1 Gene

  • Protein details for PDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUG6-PDRG1_HUMAN
    Recommended name:
    p53 and DNA damage-regulated protein 1
    Protein Accession:
    Q9NUG6
    Secondary Accessions:
    • B2R511
    • Q96GP3
    • Q9BUW8

    Protein attributes for PDRG1 Gene

    Size:
    133 amino acids
    Molecular mass:
    15511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDRG1 Gene

Proteomics data for PDRG1 Gene at MOPED

Post-translational modifications for PDRG1 Gene

  • Ubiquitination at Lys 27
  • Modification sites at PhosphoSitePlus

Other Protein References for PDRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PDRG1 Gene

Domains & Families for PDRG1 Gene

Protein Domains for PDRG1 Gene

Suggested Antigen Peptide Sequences for PDRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUG6

UniProtKB/Swiss-Prot:

PDRG1_HUMAN :
  • Belongs to the prefoldin subunit beta family.
Family:
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PDRG1: view

No data available for Gene Families for PDRG1 Gene

Function for PDRG1 Gene

Molecular function for PDRG1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chaperone-mediated protein folding.
UniProtKB/Swiss-Prot Induction:
By UV irradiation and repressed by p53/TP53.

Phenotypes for PDRG1 Gene

GenomeRNAi human phenotypes for PDRG1:
genes like me logo Genes that share phenotypes with PDRG1: view

Animal Model Products

CRISPR Products

miRNA for PDRG1 Gene

miRTarBase miRNAs that target PDRG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDRG1 Gene

Localization for PDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDRG1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDRG1 Gene COMPARTMENTS Subcellular localization image for PDRG1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PDRG1: view

Pathways & Interactions for PDRG1 Gene

SuperPathways for PDRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDRG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PDRG1 Gene

Drugs & Compounds for PDRG1 Gene

No Compound Related Data Available

Transcripts for PDRG1 Gene

mRNA/cDNA for PDRG1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(244) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDRG1 Gene

P53 and DNA-damage regulated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -
SP3:

Relevant External Links for PDRG1 Gene

GeneLoc Exon Structure for
PDRG1
ECgene alternative splicing isoforms for
PDRG1

Expression for PDRG1 Gene

mRNA expression in normal human tissues for PDRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDRG1 Gene

This gene is overexpressed in Bone marrow stromal cell (25.2) and Peripheral blood mononuclear cells (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDRG1 Gene



SOURCE GeneReport for Unigene cluster for PDRG1 Gene Hs.435755

mRNA Expression by UniProt/SwissProt for PDRG1 Gene

Q9NUG6-PDRG1_HUMAN
Tissue specificity: Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.
genes like me logo Genes that share expression patterns with PDRG1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PDRG1 Gene

Orthologs for PDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDRG1 36
  • 99 (a)
OneToOne
PDRG1 35
  • 99.25 (n)
  • 99.25 (a)
cow
(Bos Taurus)
Mammalia PDRG1 35
  • 92.48 (n)
  • 95.49 (a)
PDRG1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDRG1 36
  • 97 (a)
OneToOne
PDRG1 35
  • 91.73 (n)
  • 96.99 (a)
mouse
(Mus musculus)
Mammalia Pdrg1 16
Pdrg1 35
  • 88.22 (n)
  • 91.73 (a)
Pdrg1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDRG1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDRG1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdrg1 35
  • 86.47 (n)
  • 89.47 (a)
chicken
(Gallus gallus)
Aves PDRG1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDRG1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdrg1 35
  • 63.73 (n)
  • 62.4 (a)
zebrafish
(Danio rerio)
Actinopterygii pdrg1 35
  • 59.52 (n)
  • 61.11 (a)
pdrg1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15863 36
  • 27 (a)
OneToOne
Species with no ortholog for PDRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDRG1 Gene

ENSEMBL:
Gene Tree for PDRG1 (if available)
TreeFam:
Gene Tree for PDRG1 (if available)

Paralogs for PDRG1 Gene

Pseudogenes.org Pseudogenes for PDRG1 Gene

genes like me logo Genes that share paralogs with PDRG1: view

No data available for Paralogs for PDRG1 Gene

Variants for PDRG1 Gene

Sequence variations from dbSNP and Humsavar for PDRG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs745384 -- 31,952,914(+) TGTCC(A/G)GAGTA intron-variant, upstream-variant-2KB
rs6061049 -- 31,953,985(+) CATTA(A/G)CAGCT intron-variant, upstream-variant-2KB
rs6061050 -- 31,955,998(+) ACCAC(A/G)TCTGG intron-variant
rs6061051 -- 31,956,178(+) tactt(A/G)tggtt intron-variant
rs6061059 -- 31,961,723(+) TTTCA(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDRG1 Gene

Variant ID Type Subtype PubMed ID
nsv833952 CNV Gain 17160897

Variation tolerance for PDRG1 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDRG1 Gene

HapMap Linkage Disequilibrium report
PDRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDRG1 Gene

Disorders for PDRG1 Gene

Relevant External Links for PDRG1

Genetic Association Database (GAD)
PDRG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDRG1

No disorders were found for PDRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDRG1 Gene

Publications for PDRG1 Gene

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. (PMID: 14562055) Luo X. … Sheikh M.S. (Oncogene 2003) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3

Products for PDRG1 Gene

Sources for PDRG1 Gene

Back to Top

Content