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Aliases for PDPR Gene

Aliases for PDPR Gene

  • Pyruvate Dehydrogenase Phosphatase Regulatory Subunit 2 3
  • Pyruvate Dehydrogenase Phosphatase Regulatory Subunit, Mitochondrial 3
  • KIAA1990 4
  • PDP3 3
  • PDPr 4

External Ids for PDPR Gene

Previous GeneCards Identifiers for PDPR Gene

  • GC16P069883
  • GC16P069923
  • GC16P068705
  • GC16P070148
  • GC16P056002

Summaries for PDPR Gene

GeneCards Summary for PDPR Gene

PDPR (Pyruvate Dehydrogenase Phosphatase Regulatory Subunit) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include oxidoreductase activity and aminomethyltransferase activity. An important paralog of this gene is SARDH.

UniProtKB/Swiss-Prot for PDPR Gene

  • Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDPR Gene

Genomics for PDPR Gene

Regulatory Elements for PDPR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDPR Gene

70,113,626 bp from pter
70,162,537 bp from pter
48,912 bases
Plus strand

Genomic View for PDPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDPR Gene

Proteins for PDPR Gene

  • Protein details for PDPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A7E298
    • A8K8Y7
    • B3KSE1
    • Q6AI20
    • Q6AWC9

    Protein attributes for PDPR Gene

    879 amino acids
    Molecular mass:
    99364 Da
    Quaternary structure:
    • Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.
    • Sequence=BAC02699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85191.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PDPR Gene


neXtProt entry for PDPR Gene

Proteomics data for PDPR Gene at MOPED

Post-translational modifications for PDPR Gene

  • Ubiquitination at Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for PDPR Gene

No data available for DME Specific Peptides for PDPR Gene

Domains for PDPR Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GcvT family.
  • Belongs to the GcvT family.
genes like me logo Genes that share domains with PDPR: view

No data available for Gene Families for PDPR Gene

Function for PDPR Gene

Molecular function for PDPR Gene

UniProtKB/Swiss-Prot Function:
Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.

Gene Ontology (GO) - Molecular Function for PDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004047 aminomethyltransferase activity --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PDPR: view

Phenotypes for PDPR Gene

GenomeRNAi human phenotypes for PDPR:
genes like me logo Genes that share phenotypes with PDPR: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PDPR Gene

Localization for PDPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDPR Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for PDPR Gene COMPARTMENTS Subcellular localization image for PDPR gene
Compartment Confidence
mitochondrion 4
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PDPR: view

Pathways for PDPR Gene

genes like me logo Genes that share pathways with PDPR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PDPR Gene

Gene Ontology (GO) - Biological Process for PDPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006546 glycine catabolic process --
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS --
GO:0032259 methylation --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with PDPR: view

Compounds for PDPR Gene

(6) HMDB Compounds for PDPR Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium
  • N'-Acetylspermine
  • N-(3-aminopropyl)-1,3-Propanediamine
  • 1,4-Butanediamine
  • 1,5,10-Triazadecane
genes like me logo Genes that share compounds with PDPR: view

Transcripts for PDPR Gene

Unigene Clusters for PDPR Gene

Pyruvate dehydrogenase phosphatase regulatory subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDPR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP2: -
SP3: - -

Relevant External Links for PDPR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDPR Gene

mRNA expression in normal human tissues for PDPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PDPR Gene

This gene is overexpressed in Lymph node (8.8) and Uterus (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDPR Gene

SOURCE GeneReport for Unigene cluster for PDPR Gene Hs.744043

genes like me logo Genes that share expressions with PDPR: view

Expression partners for PDPR Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PDPR Gene

Orthologs for PDPR Gene

This gene was present in the common ancestor of animals.

Orthologs for PDPR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDPR 35
  • 88.61 (n)
  • 91.57 (a)
  • 91 (a)
(Canis familiaris)
Mammalia PDPR 35
  • 91.25 (n)
  • 95.57 (a)
  • 94 (a)
(Mus musculus)
Mammalia Pdpr 35
  • 88.61 (n)
  • 92.26 (a)
Pdpr 16
Pdpr 36
  • 92 (a)
(Pan troglodytes)
Mammalia LOC454207 35
  • 99.61 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pdpr 35
  • 88.65 (n)
  • 92.03 (a)
(Monodelphis domestica)
Mammalia PDPR 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PDPR 36
  • 86 (a)
(Gallus gallus)
Aves PDPR 35
  • 77.36 (n)
  • 83.28 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia PDPR 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdpr 35
  • 72.11 (n)
  • 79.14 (a)
Str.18754 35
(Danio rerio)
Actinopterygii pdpr 35
  • 71.2 (n)
  • 74.61 (a)
zgc63662 35
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004715 35
  • 52.31 (n)
  • 46.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3626 35
  • 53.38 (n)
  • 44.69 (a)
CG3626 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y106G6H.5 35
  • 47.22 (n)
  • 38.7 (a)
Y106G6H.5 36
  • 36 (a)
Species with no ortholog for PDPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDPR Gene

Gene Tree for PDPR (if available)
Gene Tree for PDPR (if available)

Paralogs for PDPR Gene

Paralogs for PDPR Gene

(2) SIMAP similar genes for PDPR Gene using alignment to 9 proteins: Pseudogenes for PDPR Gene

genes like me logo Genes that share paralogs with PDPR: view

Variants for PDPR Gene

Sequence variations from dbSNP and Humsavar for PDPR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7269 -- 70,162,281(+) TGTCA(A/G)TTTGC utr-variant-3-prime, nc-transcript-variant
rs14214 -- 70,160,988(+) TTGGC(A/C)CTAGA utr-variant-3-prime, nc-transcript-variant
rs676578 -- 70,138,670(+) AAATA(A/C)CTCCT intron-variant
rs729087 -- 70,162,848(+) CAAGG(G/T)GGGTC downstream-variant-500B
rs1044865 -- 70,161,678(+) CACTA(C/G)CAGTA downstream-variant-500B, utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PDPR Gene

Variant ID Type Subtype PubMed ID
dgv895e1 CNV Complex 17122850
nsv1853 CNV Loss 18451855
dgv2892n71 CNV Gain 21882294
dgv2893n71 CNV Gain 21882294
dgv485n67 CNV Loss 20364138
esv2714669 CNV Deletion 23290073
nsv428328 CNV Gain+Loss 18775914
dgv2895n71 CNV Loss 21882294
nsv436059 CNV Insertion 17901297
esv2657437 CNV Deletion 23128226
dgv2896n71 CNV Gain 21882294
dgv2897n71 CNV Gain 21882294
nsv827719 CNV Gain 20364138
nsv833269 CNV Loss 17160897
nsv827723 CNV Loss 20364138
nsv820087 CNV Loss 19587683
essv1325 CNV CNV 17122850
dgv2898n71 CNV Gain 21882294
nsv469646 CNV Gain 16826518
nsv471695 CNV Loss 15918152
dgv2899n71 CNV Gain 21882294
esv33745 CNV Gain+Loss 17666407
dgv896e1 CNV Complex 17122850
esv997919 CNV Loss 20482838
dgv2900n71 CNV Gain 21882294
dgv2901n71 CNV Gain 21882294
nsv9455 CNV Gain+Loss 18304495
esv25519 CNV Gain+Loss 19812545
dgv486n67 CNV Gain 20364138
nsv820860 CNV Duplication 20802225
nsv471391 CNV Duplication 19718026
nsv482195 CNV Gain 20164927
nsv514810 CNV Complex 21397061
nsv442725 CNV CNV 18776908
nsv827728 CNV Loss 20364138
esv1007882 CNV Loss 20482838
nsv906863 CNV Gain 21882294
nsv7285 OTHER Inversion 18451855
dgv2902n71 CNV Gain 21882294
esv2577915 CNV Gain 19546169
esv29970 CNV Loss 17803354
nsv906866 CNV Gain 21882294
nsv833271 CNV Gain+Loss 17160897
nsv906867 CNV Gain 21882294

Relevant External Links for PDPR Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDPR Gene

Disorders for PDPR Gene

Relevant External Links for PDPR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PDPR Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PDPR Gene

Publications for PDPR Gene

  1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 48
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase. (PMID: 9395502) Lawson J.E. … Reed L.J. (J. Biol. Chem. 1997) 2 3
  4. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PDPR Gene

Sources for PDPR Gene

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