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Aliases for PDPN Gene

Aliases for PDPN Gene

  • Podoplanin 2 3 5
  • Lung Type I Cell Membrane Associated Glycoprotein 2 3
  • Glycoprotein 36 3 4
  • PA2.26 Antigen 3 4
  • T1-Alpha 3 4
  • AGGRUS 3 4
  • GP36 3 4
  • T1A 3 4
  • Lung Type-I Cell Membrane-Associated Glycoprotein (T1A-2) 3
  • Glycoprotein, 36-KD 3
  • HT1alpha-1 3
  • HT1alpha-2 3
  • HT1A-1 3
  • PA2.26 3
  • T1A-2 3
  • GP40 3
  • Gp38 3
  • OTS8 3
  • T1A2 3
  • TI1A 3

External Ids for PDPN Gene

Previous GeneCards Identifiers for PDPN Gene

  • GC01P013782
  • GC01P013909
  • GC01P012427

Summaries for PDPN Gene

Entrez Gene Summary for PDPN Gene

  • This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDPN Gene

PDPN (Podoplanin) is a Protein Coding gene. Diseases associated with PDPN include subglottis neoplasm and seminoma. Among its related pathways are Cytoskeletal Signaling and G beta-gamma signalling through PI3Kgamma. GO annotations related to this gene include amino acid transmembrane transporter activity and folic acid transporter activity.

UniProtKB/Swiss-Prot for PDPN Gene

  • May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Gene Wiki entry for PDPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDPN Gene

Genomics for PDPN Gene

Regulatory Elements for PDPN Gene

Enhancers for PDPN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDPN on UCSC Golden Path with GeneCards custom track

Promoters for PDPN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDPN on UCSC Golden Path with GeneCards custom track

Genomic Location for PDPN Gene

Chromosome:
1
Start:
13,583,465 bp from pter
End:
13,617,957 bp from pter
Size:
34,493 bases
Orientation:
Plus strand

Genomic View for PDPN Gene

Genes around PDPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDPN Gene

Proteins for PDPN Gene

  • Protein details for PDPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YL7-PDPN_HUMAN
    Recommended name:
    Podoplanin
    Protein Accession:
    Q86YL7
    Secondary Accessions:
    • A9Z1Y2
    • B2R6J8
    • E9PB68
    • F6QWX5
    • O60836
    • O95128
    • Q7L375
    • Q8NBQ8
    • Q8NBR3

    Protein attributes for PDPN Gene

    Size:
    162 amino acids
    Molecular mass:
    16698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM73655.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO22143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11557.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35495.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDPN Gene

    Alternative splice isoforms for PDPN Gene

neXtProt entry for PDPN Gene

Proteomics data for PDPN Gene at MOPED

Post-translational modifications for PDPN Gene

  • Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
  • The N-terminus is blocked.
  • Glycosylation at Thr 25, Thr 32, Thr 34, Thr 35, Thr 52, Thr 55, Thr 65, Thr 66, Thr 76, Thr 85, Ser 86, Ser 88, Thr 89, Ser 96, Ser 98, Thr 100, Ser 102, Thr 106, Ser 107, Ser 109, Thr 110, Thr 117, Thr 119, and Thr 120
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDPN (PDPN)

No data available for DME Specific Peptides for PDPN Gene

Domains & Families for PDPN Gene

Protein Domains for PDPN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PDPN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YL7

UniProtKB/Swiss-Prot:

PDPN_HUMAN :
  • Belongs to the podoplanin family.
Family:
  • Belongs to the podoplanin family.
genes like me logo Genes that share domains with PDPN: view

No data available for Gene Families for PDPN Gene

Function for PDPN Gene

Molecular function for PDPN Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Gene Ontology (GO) - Molecular Function for PDPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008517 NOT folic acid transporter activity ISS --
genes like me logo Genes that share ontologies with PDPN: view
genes like me logo Genes that share phenotypes with PDPN: view

Animal Models for PDPN Gene

MGI Knock Outs for PDPN:

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDPN Gene

Localization for PDPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDPN Gene

Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDPN Gene COMPARTMENTS Subcellular localization image for PDPN gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031527 filopodium membrane IEA --
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with PDPN: view

Pathways & Interactions for PDPN Gene

genes like me logo Genes that share pathways with PDPN: view

Pathways by source for PDPN Gene

1 Cell Signaling Technology pathway for PDPN Gene

Interacting Proteins for PDPN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000294489%0d%0a9606.ENSP00000460823%0d%0a
Selected Interacting proteins: ENSP00000294489 Q86YL7-PDPN_HUMAN for PDPN Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for PDPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006865 NOT amino acid transport ISS --
GO:0007165 signal transduction IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030168 platelet activation TAS --
GO:0030324 lung development ISS --
genes like me logo Genes that share ontologies with PDPN: view

No data available for SIGNOR curated interactions for PDPN Gene

Drugs & Compounds for PDPN Gene

(2) Drugs for PDPN Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Analgesics Pharma 10729

(7) Additional Compounds for PDPN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PDPN: view

Transcripts for PDPN Gene

Unigene Clusters for PDPN Gene

Podoplanin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDPN Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8: -

Relevant External Links for PDPN Gene

GeneLoc Exon Structure for
PDPN
ECgene alternative splicing isoforms for
PDPN

Expression for PDPN Gene

mRNA expression in normal human tissues for PDPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDPN Gene

This gene is overexpressed in Fetal Brain (21.6), Prostate (17.6), Testis (15.9), and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDPN Gene



SOURCE GeneReport for Unigene cluster for PDPN Gene Hs.468675

mRNA Expression by UniProt/SwissProt for PDPN Gene

Q86YL7-PDPN_HUMAN
Tissue specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
genes like me logo Genes that share expression patterns with PDPN: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PDPN Gene

Orthologs for PDPN Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDPN Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PDPN 35
  • 77.57 (n)
  • 66.67 (a)
PDPN 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdpn 35
  • 63.99 (n)
  • 48.15 (a)
Pdpn 16
Pdpn 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDPN 35
  • 99.3 (n)
  • 98.74 (a)
PDPN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdpn 35
  • 64.69 (n)
  • 53.95 (a)
cow
(Bos Taurus)
Mammalia BOVAGGRUS 36
  • 46 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDPN 36
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDPN 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDPN 36
  • 37 (a)
OneToOne
Species with no ortholog for PDPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PDPN Gene

ENSEMBL:
Gene Tree for PDPN (if available)
TreeFam:
Gene Tree for PDPN (if available)

Paralogs for PDPN Gene

No data available for Paralogs for PDPN Gene

Variants for PDPN Gene

Sequence variations from dbSNP and Humsavar for PDPN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2486188 -, - 13,614,369(-) TGATT(C/G)CACCA reference, missense
rs11880 -- 13,616,236(+) TATTA(C/T)ATGCT utr-variant-3-prime
rs92406 -- 13,608,907(-) AAAAG(G/T)CAGcc intron-variant
rs173312 -- 13,592,862(+) tgatt(C/G)tttct intron-variant
rs355022 -- 13,582,195(+) CTTCA(C/T)TGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PDPN Gene

Variant ID Type Subtype PubMed ID
nsv871035 CNV Gain 21882294
nsv833092 CNV Loss 17160897
nsv460483 CNV Loss 19166990
esv2744064 CNV Deletion 23290073
esv270520 CNV Insertion 20981092

Variation tolerance for PDPN Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDPN Gene

HapMap Linkage Disequilibrium report
PDPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDPN Gene

Disorders for PDPN Gene

MalaCards: The human disease database

(29) MalaCards diseases for PDPN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
subglottis neoplasm
  • subglottic tumor
seminoma
  • seminoma, pure
atypical neurofibroma
hemangioma
kaposi sarcoma
  • human herpesvirus 8
- elite association - COSMIC cancer census association via MalaCards
Search PDPN in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDPN

Genetic Association Database (GAD)
PDPN
Human Genome Epidemiology (HuGE) Navigator
PDPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDPN
genes like me logo Genes that share disorders with PDPN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDPN Gene

Publications for PDPN Gene

  1. Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. (PMID: 9651190) Ma T. … Verkman A.S. (Am. J. Respir. Cell Mol. Biol. 1998) 2 3 4 23 67
  2. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. (PMID: 10393083) Zimmer G. … Herrler G. (Biochem. J. 1999) 2 3 23
  3. Significance of podoplanin expression in keratocystic odontogenic tumor. (PMID: 19925582) Okamoto E. … Kusama K. (J. Oral Pathol. Med. 2010) 3 23
  4. Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma. (PMID: 20066519) Rahadiani N. … Morii E. (Ann. Surg. Oncol. 2010) 3 23
  5. Podoplanin is a useful marker for identifying mesothelioma in malignant effusions. (PMID: 20146302) Hanna A. … Michael C.W. (Diagn. Cytopathol. 2010) 3 23

Products for PDPN Gene

Sources for PDPN Gene

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