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PDPK1 Gene

protein-coding   GIFtS: 75
GCID: GC16P002587

3-Phosphoinositide Dependent Protein Kinase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
3-Phosphoinositide Dependent Protein Kinase 11 2     PDPK22
PDK12 3 5     PRO04612
EC 2.7.11.13 8     PkB Kinase Like Gene 12
PkB Kinase1     hPDK13
3-Phosphoinositide Dependent Protein Kinase-12     EC 2.7.118
3-Phosphoinositide-Dependent Protein Kinase 12     

External Ids:    HGNC: 88161   Entrez Gene: 51702   Ensembl: ENSG000001409927   OMIM: 6052135   UniProtKB: O155303   

Export aliases for PDPK1 gene to outside databases

Previous GC identifers: GC16M002672 GC16P002634 GC16P002527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PDPK1 Gene:
PDPK1 (3-phosphoinositide dependent protein kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and insulin receptor binding.

UniProtKB/Swiss-Prot: PDPK1_HUMAN, O15530
Function: Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the
AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70
ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic
AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible
kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central
role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus
propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and
amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association
of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear
translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to
TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the
NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of
focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells.
Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for
the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a
critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic
response. Plays an important role during thymocyte development by regulating the expression of key nutrient
receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses.
Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages.
Isoform 3 is catalytically inactive

summary for PDPK1 Gene:
Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the
function of the PI 3-K/Akt signaling pathway. PDK1 and mTORC2 both phosphorylate and activate PKB/Akt,
ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main
effector of PDK1.

Gene Wiki entry for PDPK1 (Phosphoinositide-dependent kinase-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDPK1 gene promoter:
         XBP-1   CUTL1   Tal-1beta   E47   CREB   POU2F1   POU2F1a   ARP-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDPK1 promoter sequence
   Search Chromatin IP Primers for PDPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PDPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDPK1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002587:  view genomic region     (about GC identifiers)

Start:
2,587,965 bp from pter      End:
2,653,189 bp from pter
Size:
65,225 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PDPK1_HUMAN, O15530 (See protein sequence)
Recommended Name: 3-phosphoinositide-dependent protein kinase 1  
Size: 556 amino acids; 63152 Da
Subunit: Homodimer in its autoinhibited state. Active as monomer. Interacts with NPRL2, PPARG, PAK1, PTK2B, GRB14,
PKN1 (via C-terminus), STRAP and IKKB. The Tyr-9 phosphorylated form interacts with SRC, RASA1 and CRK (via their
SH2 domains). Interacts with SGK3 in a phosphorylation-dependent manner. The tyrosine-phosphorylated form
interacts with PTPN6. The Ser-241 phosphorylated form interacts with YWHAH and YWHAQ. Binds INSR in response to
insulin. Interacts (via PH domain) with SMAD3, SMAD4 and SMAD7. Interacts with PKN2; the interaction stimulates
PDPK1 autophosphorylation, its PI(3,4,5)P3-dependent kinase activity toward 'Ser-473' of AKT1 but also activates
its kinase activity toward PRKCD and PRKCZ
Sequence caution: Sequence=BAD93072.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for PDPK1 (see all 51):
1H1W (3D)        1OKY (3D)        1OKZ (3D)        1UU3 (3D)        1UU7 (3D)        1UU8 (3D)    
Secondary accessions: H0Y4Z0 Q59EH6 Q6FI20 Q8IV52 Q9BRD5
Alternative splicing: 5 isoforms:  O15530-1   O15530-2   O15530-3   O15530-4   O15530-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDPK1: NX_O15530

Explore proteomics data for PDPK1 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-241 in the activation loop is required for full activity. PDPK1 itself can
    autophosphorylate Ser-241, leading to its own activation. Autophosphorylation is inhibited by the apoptotic
    C-terminus cleavage product of PKN2 (By similarity). Tyr-9 phosphorylation is critical for stabilization of both
    PDPK1 and the PDPK1/SRC complex via HSP90-mediated protection of PDPK1 degradation. Angiotensin II stimulates the
    tyrosine phosphorylation of PDPK1 in vascular smooth muscle in a calcium- and SRC-dependent manner.
    Phosphorylated on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin. Palmitate negatively regulates
    autophosphorylation at Ser-241 and palmitate-induced phosphorylation at Ser-529 and Ser-501 by PKC/PRKCQ
    negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylation at Thr-354 by MELK partially inhibits
    kinase activity, the inhibition is cooperatively enhanced by phosphorylation at Ser-394 and Ser-398 by MAP3K51
  • Autophosphorylated; autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2 (By
    similarity)1
  • Monoubiquitinated in the kinase domain, deubiquitinated by USP41
  • Ubiquitination2 at Lys304, Lys323, Lys441
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDPK1 (O15530) (see all 11)
     AEIVSAL  LEYDFPE  KSSDLWA  RDLKPEN 


    See PDPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001248745.1  NP_002604.1  NP_112558.2  

    ENSEMBL proteins: 
     ENSP00000344220   ENSP00000455492   ENSP00000395357   ENSP00000268673   ENSP00000455025  
     ENSP00000455684   ENSP00000373876   ENSP00000455551   ENSP00000455438   ENSP00000346895  
    Reactome Protein details: O15530

    PDPK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PDPK1 Protein
    R&D Systems Recombinant & Natural Proteins for PDPK1 (PDK-1)
    Enzo Life Sciences proteins for PDPK1
    OriGene Purified Protein for PDPK1
    OriGene Protein Over-expression Lysate for PDPK1
    OriGene MassSpec for PDPK1
    OriGene Custom Protein Services for PDPK1
    GenScript Custom Purified and Recombinant Proteins Services for PDPK1
    Novus Biologicals PDPK1 Proteins
    Novus Biologicals PDPK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDPK1

     
    Search eBioscience for Proteins for PDPK1 

     
    antibodies-online proteins for PDPK1 (8 products) 

     
    antibodies-online peptides for PDPK1

    PDPK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for PDPK1
    Novus Biologicals PDPK1 Antibodies
    Abcam antibodies for PDPK1
    Cloud-Clone Corp. Antibodies for PDPK1
    ThermoFisher Antibodies for PDPK1
    antibodies-online antibodies for PDPK1 (158 products) 

    PDPK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDPK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDPK1
    Cloud-Clone Corp. CLIAs for PDPK1
    Search eBioscience for ELISAs for PDPK1 
    antibodies-online kits for PDPK1 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: 3-phosphoinositide dependent protein kinase-1
    PDK1 family
    Other AGC kinases

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O15530

    ProtoNet protein and cluster: O15530

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PDPK1_HUMAN, O15530
    Domain: The PH domain plays a pivotal role in the localization and nuclear import of PDPK1 and is also essential
    for its homodimerization
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PDPK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDPK1_HUMAN, O15530
    Function: Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the
    AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70
    ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic
    AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible
    kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central
    role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus
    propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and
    amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association
    of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear
    translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to
    TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the
    NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of
    focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells.
    Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for
    the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a
    critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic
    response. Plays an important role during thymocyte development by regulating the expression of key nutrient
    receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses.
    Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages.
    Isoform 3 is catalytically inactive
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization regulates its activity by maintaining the kinase in an autoinhibitory
    conformation. NPRL2 down-regulates its activity by interfering with tyrosine phosphorylation at the Tyr-9,
    Tyr-373 and Tyr-376 residues. The 14-3-3 protein YWHAQ acts as a negative regulator by association with the
    residues surrounding the Ser-241 residue. STRAP positively regulates its activity by enhancing its
    autophosphorylation and by stimulating its dissociation from YWHAQ. SMAD2, SMAD3, SMAD4 and SMAD7 also positively
    regulate its activity by stimulating its dissociation from YWHAQ. Activated by phosphorylation on Tyr-9, Tyr-373
    and Tyr-376 by INSR in response to insulin
    Induction: Stimulated by insulin, and the oxidants hydrogen peroxide and peroxovanadate

         Genatlas biochemistry entry for PDPK1:
    3-phosphoinositide (PtdIns(3,4,5)P3,PtdIns(3,4)P2)-dependent kinase 1,ubiquitously expressed,homolog to Drosophila
    DSTPK61 kinase,likely mediating the activation of protein-kinase B AKT/PKB by insulin or growth factors

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:00046763-phosphoinositide-dependent protein kinase activity IDA9368760
    GO:0004713protein tyrosine kinase activity ----
    GO:0005158insulin receptor binding IEA--
         
    Find genes that share ontologies with PDPK1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PDPK1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Pdpk1) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with PDPK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pdpk1tm1.2Mlw for PDPK1

       genOway: Develop your customized and physiologically relevant rodent model for PDPK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDPK1:
    hsa-mir-744-5p (MIRT037453), hsa-mir-17-5p (MIRT051003), hsa-mir-423-5p (MIRT038100), hsa-mir-125a-5p (MIRT021308), hsa-mir-331-3p (MIRT043522), hsa-mir-24-3p (MIRT030439), hsa-mir-185-5p (MIRT045314), hsa-mir-128-3p (MIRT021893), hsa-mir-10a-5p (MIRT025610)

    Block miRNA regulation of human, mouse, rat PDPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDPK1 (see all 75):
    hsa-miR-128 hsa-miR-374a hsa-miR-3138 hsa-miR-10b* hsa-miR-556-3p hsa-miR-200b hsa-miR-3148 hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat PDPK1

    Gene Editing
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    OriGene clones in human, mouse for PDPK1 (see all 14)
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    GenScript: all cDNA clones in your preferred vector (see all 2): PDPK1 (NM_002613)
    Sino Biological Human cDNA Clone for PDPK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDPK1
    Addgene plasmids for PDPK1 

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    eBioscience FlowRNA Probe Sets ( VA1-12253) for PDPK1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDPK1_HUMAN, O15530: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal
    adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell
    membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90
    promote its localization to the cell membrane. Its nuclear localization is dependent on its association with
    PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells
    it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in
    neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently
    increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular
    compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II
    stimulation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    mitochondrion2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IEA--

    Find genes that share ontologies with PDPK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDPK1 About   (see all 102)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    2B cell receptor signaling pathway (KEGG)
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36
    T cell receptor signaling pathway0.38
    3Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    4IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines and Insulin Signaling0.34
    5Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF4F0.44
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    mTOR signaling pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF20.47


    Find genes that share SuperPaths with PDPK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for PDPK1 (see all 11)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDPK1 (see all 38)
        FLT3 Signaling
    LT-BetaR Pathway
    IL-4 Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for PDPK1
        PI3K / Akt Signaling

    3 Tocris Bioscience Pathways for PDPK1
        Akt Pathway
    Insulin Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PDPK1 (see all 44)
        Development A2A receptor signaling
    Development FGF-family signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for PDPK1 (see all 29)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    Insulin Signaling
    BDNF signaling pathway


    Selected Reactome Pathways for PDPK1 (see all 12)
        Activation of PKB
    FCERI mediated NF-kB activation
    Role of LAT2/NTAL/LAB on calcium mobilization
    GPVI-mediated activation cascade
    CD28 dependent PI3K/Akt signaling


    Selected Kegg Pathways  (Kegg details for PDPK1) (see all 17):
        PPAR signaling pathway
    FoxO signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDPK1 (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Prostate Cancer in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PDPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDPK1 (O155301, 2, 3 ENSP000003442204) via UniProtKB, MINT, STRING, and/or I2D (see all 500)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003323type B pancreatic cell development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation IDA14585963
    GO:0006469negative regulation of protein kinase activity IDA9373175

    Find genes that share ontologies with PDPK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PDPK1
    4 ApexBio Compounds for PDPK1     About this table
    CompoundAction CAS #
    BX-912BX-912 is a PDK-1 inhibitor[702674-56-4]
    NVP-BAG956potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor [853910-02-8]
    OSU-03012 (AR-12)OSU 03012 is a potent inhibitor of PDK1 (IC50 = 5 uM)[742112-33-0]
    PDK1 inhibitorAn potent and selective inhibitor of PDK1 with potential as anticancer agent[1001409-50-2]

    Compounds for PDPK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PS 48PDK1 activator[1180676-32-7]
    BAG 956Dual PI 3-kinase and PDK1 inhibitor[853910-02-8]
    GSK 2334470 Highly potent, selective PDK1 inhibitor [1227911-45-6]
    BX 795PDK1 inhibitor[702675-74-9]

    3 HMDB Compounds for PDPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CelecoxibCelebrex (see all 3)169590-42-5--

    Selected DrugBank Compounds for PDPK1 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Celecoxib-- 169590-42-5targetinhibitor16060857 14973075 16887935 16455452 15205346
    3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione-- --target--17139284 17016423 10592235
    7-Hydroxystaurosporine-- 112953-11-4target--17139284 17016423
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423
    Phosphonoserine-- --target--17139284 17016423
    Staurosporine-- 62996-74-1target--17139284 17016423
    1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA-- --target--10592235
    10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine-- --target--10592235
    2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine-- --target--10592235
    3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PDPK1 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 79.2 47 12183455 (2), 9799739 (1), 11060301 (1), 15520204 (1) (see all 32)
    phosphatidylinositol-3,4,5-trisphosphate 78.4 9 9768361 (1), 9637919 (1), 11882383 (1), 15537704 (1) (see all 9)
    phosphoinositide 78 76 11897568 (3), 19061482 (2), 9637919 (2), 18790745 (2) (see all 40)
    threonine 71.1 25 15567163 (2), 15743412 (2), 14570903 (1), 17617409 (1) (see all 17)
    7-hydroxystaurosporine 70.8 5 12892559 (2), 16284058 (1), 17429623 (1)
    rapamycin 68.4 10 19061482 (1), 19153210 (1), 16787414 (1), 12668683 (1) (see all 9)
    wortmannin 67.4 11 11054117 (2), 11907830 (1), 10995762 (1), 11096081 (1) (see all 7)
    ly294002 65.2 4 18174238 (2), 11907830 (1), 14645548 (1)
    pkcs 62.5 8 17617409 (2), 11368419 (1), 16923125 (1), 17392460 (1)
    serine 61.2 21 15567163 (2), 14570903 (1), 17617409 (1), 19276999 (1) (see all 16)



    Find genes that share compounds with PDPK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PDPK1 gene (3 alternative transcripts): 
    NM_001261816.1  NM_002613.4  NM_031268.5  

    Unigene Cluster for PDPK1:

    3-phosphoinositide dependent protein kinase-1
    Hs.459691  [show with all ESTs]
    Unigene Representative Sequence: NM_002613
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000342085(uc002cqs.3 uc002cqt.3 uc010bsn.3 uc002cqu.3)
    ENST00000566659 ENST00000441549 ENST00000268673 ENST00000462923 ENST00000474706
    ENST00000492021 ENST00000570136(uc010uwe.1) ENST00000389224 ENST00000461815
    ENST00000602572 ENST00000491073(uc002cqv.1) ENST00000460496 ENST00000464702
    ENST00000471311 ENST00000478708 ENST00000569721 ENST00000561962
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDPK1 (see all 75):
    hsa-miR-128 hsa-miR-374a hsa-miR-3138 hsa-miR-10b* hsa-miR-556-3p hsa-miR-200b hsa-miR-3148 hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDPK1
    Predesigned siRNA for gene silencing in human, mouse, rat PDPK1
    Clone
    Products:
         
    OriGene clones in human, mouse for PDPK1 (see all 14)
    OriGene ORF clones in mouse, rat for PDPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDPK1 (NM_002613)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDPK1
    Addgene plasmids for PDPK1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for PDPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDPK1
      QuantiTect SYBR Green Assays in human, mouse, rat PDPK1
      QuantiFast Probe-based Assays in human, mouse, rat PDPK1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12253) for PDPK1 

    Additional mRNA sequence: 

    AB209835.1 AF017995.1 AF111845.2 AJ785968.1 AK093687.1 AK095507.1 AK131060.1 AK222581.1 
    AL157446.1 BC000789.1 BC006339.2 BC012103.1 BC012540.1 BC033494.1 BC040324.1 CR536517.1 
    Y15056.1 

    Selected DOTS entries (see all 25):

    DT.100785196  DT.449221  DT.100025648  DT.95374105  DT.91962365  DT.91931583  DT.92434118  DT.95157696 
    DT.95157697  DT.101983627  DT.70103679  DT.92039625  DT.100719463  DT.102830651  DT.120706556  DT.95150360 
    DT.99930183  DT.120706438  DT.40202251  DT.95357717  DT.100785191  DT.101969931  DT.120706432  DT.120706520 

    Selected AceView cDNA sequences (see all 379):

    BX283735 BM564865 BE550498 BM987038 BM787914 AI677661 BC033494 BM128828 
    AI934960 BC040324 AL040828 BU957141 AI753561 BC012103 AA447421 AI222823 
    AA341226 AI468536 BC000789 W01235 BM839439 AA594087 AW194773 AI202572 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDPK1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                                                                                                
    SP2:                                                        -     -     -     -     -                                                               
    SP3:              -     -     -     -                                                                                                               
    SP4:                                -                                                                                                               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PDPK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAGTGTAA
    PDPK1 Expression
    About this image


    PDPK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PDPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDPK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459691

    UniProtKB/Swiss-Prot: PDPK1_HUMAN, O15530
    Tissue specificity: Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in
    diseased tissue compared with normal tissue from lung, liver, colon and breast

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDPK1 (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Prostate Cancer in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for PDPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDPK1
    QuantiTect SYBR Green Assays in human, mouse, rat PDPK1
    QuantiFast Probe-based Assays in human, mouse, rat PDPK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDPK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDPK1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdpk11 , 5 3-phosphoinositide dependent protein kinase 11, 5 88.37(n)1
    95.14(a)1
      17 (12.23 cM)5
    186071  NM_011062.41  NP_035192.21 
     240736805 
    chicken
    (Gallus gallus)
    Aves PDPK11 3-phosphoinositide dependent protein kinase-1 78.26(n)
    89.86(a)
      416588  NM_001012529.1  NP_001012547.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDPK16
    3-phosphoinositide dependent protein kinase-1
    88(a)
    1 ↔ 1
    GL343612.1(214229-230149)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158492 Xenopus laevis transcribed sequence with moderate similarity more 79.03(n)    BX843060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.143832 Transcribed sequence with moderate similarity to protein more 79.78(n)    BQ450455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk61C3
    Pdk11
    protein amino acid phosphorylation
    protein serine/threonine more3
    Phosphoinositide-dependent kinase 11
    46(a)3
    53.56(n)1
    51.4(a)1
      61B13
    380171  NM_167792.31  NP_728473.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W04B5.53
    pdk-11
    protein kinase3
    pdk-11
    41(a)3
    50.85(n)1
    43.27(a)1
      III(2483062-2490008)3
    1804751  NM_001029571.21  NP_001024742.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PKH16
    PKH36
    (see all 3)
    Serine/threonine protein kinase involved in sphing...
    Protein kinase with similarity to mammalian phosph...
    (see all 3)
    25(a)
    20(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    IV(1431968-1434268) YDR490C
    IV(1395121-1397817) YDR466W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PDK11 PDK1 51.12(n)
    44.32(a)
      830330  NM_120533.4  NP_568138.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08728001 Os01g0872800 49.61(n)
    43.95(a)
      4324953  NM_001051483.1  NP_001044948.1 


    ENSEMBL Gene Tree for PDPK1 (if available)
    TreeFam Gene Tree for PDPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDPK1 gene
    Selected SIMAP similar genes for PDPK1 using alignment to 8 protein entries:     PDPK1_HUMAN (see all proteins) (see all similar genes):
    PkB-like 2    PDPK2    PkB-like 1    STK11    PRKACB    KIN27
    MARK2    MARK3    STK32A    RPS6KA3    RPS6KA1    PRKACA
    RPS6KA5    RPS6KA2    DMPK    RPS6KB2    PRKAA1    CIT

    Find genes that share paralogs with PDPK1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PDPK1
    PGOHUM00000262269 PGOHUM00000262270 PGOHUM00000262271


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDPK1 (see all 671)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29070511,2
    C--2549231(+) CCCGTA/TTGAGC 3 -- int10--------
    rs1996194271,2
    --2550845(-) GCGCT-/ACCACGC 3 -- int10--------
    rs37439781,2
    F--2551068(+) CTTAAA/GTATAT 5 K syn1 int11Minor allele frequency- G:0.01EA 1494
    rs562096431,2
    C--2551516(+) TTCTTC/TCTGGT 3 -- int10--------
    rs37854121,2
    F--2552863(+) GGACGC/TGAGTG 3 -- int11Minor allele frequency- T:0.02EA 1092
    rs794333451,2
    C--2567751(-) ATTCCC/TTTTCA 3 -- int10--------
    rs20581431,2
    C--2568287(-) GGTGCT/CGGAGC 3 -- int13Minor allele frequency- C:0.00NA EA 252
    rs1480915241,2
    --2586034(+) AGCCTC/TTGCAC 3 -- us2k10--------
    rs1409214001,2
    --2586194(+) TCACAA/GCGTCA 3 -- us2k10--------
    rs1898692411,2
    --2586242(+) TGGCCA/GTAGAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDPK1 (2587965 - 2653189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDPK1 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750386CNV Deletion23290073
    esv2422427CNV Duplication17116639
    dgv2571n71CNV Loss21882294
    dgv2545n71CNV Loss21882294
    nsv510672CNV Loss20534489
    nsv9333CNV Loss18304495
    nsv905152CNV Loss21882294
    nsv905139CNV Loss21882294
    dgv2570n71CNV Loss21882294
    nsv905153CNV Loss21882294

    Human Gene Mutation Database (HGMD): PDPK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDPK1
    DNA2.0 Custom Variant and Variant Library Synthesis for PDPK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605213    OMIM disorders: --


    Find genes that share disorders with PDPK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PDPK1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 36.3 25 18542064 (3), 20197379 (2), 19602588 (2), 19061482 (1) (see all 14)
    tumors 24.3 36 20197379 (3), 19602588 (3), 16243031 (2), 19291795 (1) (see all 18)
    glioblastoma 16.6 3 11102805 (1), 19591923 (1)
    retinoblastoma 15.3 1 19706764 (1)
    prostate cancer 13.2 1 19822882 (1)
    metastasis 4.34 1 19531564 (1)
    insulin resistance 2.78 3 12882908 (1), 20018868 (1)
    breast cancer 2.04 26 16782806 (4), 19531564 (3), 16288304 (3), 19602588 (3) (see all 11)
    leukemia 0 1 16670263 (1)
    necrosis 0 5 19920149 (1)

    Genetic Association Database (GAD): PDPK1
    Human Genome Epidemiology (HuGE) Navigator: PDPK1 (4 documents)

    Export disorders for PDPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDPK1 gene, integrated from 10 sources (see all 427):
    (articles sorted by number of sources associating them with PDPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5- trisphosphate-dependent activation of protein kinase B. (PubMed id 9445477)1, 2, 3 Stephens L.R.... Hawkins P.T. (Science 1998)
    2. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. (PubMed id 9094314)1, 2, 3 Alessi D.R.... Cohen P. (Curr. Biol. 1997)
    3. Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. (PubMed id 18024423)1, 2, 9 Yang K.J.... Park J. (J. Biol. Chem. 2008)
    4. 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. (PubMed id 9368760)1, 2, 9 Alessi D.R.... Bownes M. (Curr. Biol. 1997)
    5. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. (PubMed id 10226025)1, 2, 9 Balendran A.... Alessi D.R. (Curr. Biol. 1999)
    6. 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. (PubMed id 17327236)1, 2, 9 Seong H.A.... Ha H. (J. Biol. Chem. 2007)
    7. Identification of tyrosine phosphorylation sites on 3- phosphoinositide-dependent protein kinase-1 (PDK1) and their role in regulating kinase activity. (PubMed id 11481331)1, 2, 9 Park J....Hemmings B.A. (J. Biol. Chem. 2001)
    8. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. (PubMed id 9637919)1, 2, 9 Anderson K.E.... Hawkins P.T. (Curr. Biol. 1998)
    9. TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. (PubMed id 18616680)1, 2, 9 Kurata A.... Fujita N. (Cancer Sci. 2008)
    10. Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. (PubMed id 15743829)1, 2, 9 Scheid M.P.... Woodgett J.R. (Mol. Cell. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5170 HGNC: 8816 AceView: PDPK1 Ensembl:ENSG00000140992 euGenes: HUgn5170
    ECgene: PDPK1 Kegg: 5170 H-InvDB: PDPK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDPK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDPK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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