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Aliases for PDP2 Gene

Aliases for PDP2 Gene

  • Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 2 2 3
  • Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 3 4
  • EC 3.1.3.43 4 63
  • KIAA1348 4 6
  • PDPC 2 3 4
  • [Pyruvate Dehydrogenase [Acetyl-Transferring]]-Phosphatase 2, Mitochondrial 3
  • Protein Phosphatase 2C, Magnesium-Dependent, Catalytic Subunit 2 3
  • Pyruvate Dehydrogenase Phosphatase, Catalytic Subunit 2 3
  • Pyruvate Dehydrogenase Phosphatase Isoenzyme 2 3
  • Protein Phosphatase 2C 2
  • Magnesium-Dependent 2
  • Catalytic Subunit 2 2
  • EC 3.1.3 63
  • PPM2C2 3
  • PDP 2 4

External Ids for PDP2 Gene

Previous GeneCards Identifiers for PDP2 Gene

  • GC16P066690
  • GC16P065471
  • GC16P066914
  • GC16P052788

Summaries for PDP2 Gene

GeneCards Summary for PDP2 Gene

PDP2 (Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include [pyruvate dehydrogenase (lipoamide)] phosphatase activity and magnesium-dependent protein serine/threonine phosphatase activity. An important paralog of this gene is PDP1.

UniProtKB/Swiss-Prot for PDP2 Gene

  • Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDP2 Gene

Genomics for PDP2 Gene

Regulatory Elements for PDP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDP2 Gene

Start:
66,878,589 bp from pter
End:
66,895,754 bp from pter
Size:
17,166 bases
Orientation:
Plus strand

Genomic View for PDP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDP2 Gene

Proteins for PDP2 Gene

  • Protein details for PDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J9-PDP2_HUMAN
    Recommended name:
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
    Protein Accession:
    Q9P2J9
    Secondary Accessions:
    • A8K924

    Protein attributes for PDP2 Gene

    Size:
    529 amino acids
    Molecular mass:
    59978 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Heterodimer of a catalytic subunit and a FAD protein of unknown function.
    SequenceCaution:
    • Sequence=BAA92586.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PDP2 Gene

Proteomics data for PDP2 Gene at MOPED

Selected DME Specific Peptides for PDP2 Gene

Post-translational modifications for PDP2 Gene

  • Ubiquitination at Lys438 and Lys459
  • Modification sites at PhosphoSitePlus

Other Protein References for PDP2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PDP2

Domains for PDP2 Gene

Gene Families for PDP2 Gene

HGNC:
  • PPM :Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

Protein Domains for PDP2 Gene

Suggested Antigen Peptide Sequences for PDP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2J9

UniProtKB/Swiss-Prot:

PDP2_HUMAN :
  • Q9P2J9
Domain:
  • Contains 1 PPM-type phosphatase domain.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PDP2: view

Function for PDP2 Gene

Molecular function for PDP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
UniProtKB/Swiss-Prot Function:
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

Enzyme Numbers (IUBMB) for PDP2 Gene

Gene Ontology (GO) - Molecular Function for PDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004722 protein serine/threonine phosphatase activity --
GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity IEA --
GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDP2: view

Phenotypes for PDP2 Gene

GenomeRNAi human phenotypes for PDP2:
genes like me logo Genes that share phenotypes with PDP2: view

Animal Model Products

CRISPR Products

miRNA for PDP2 Gene

miRTarBase miRNAs that target PDP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDP2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PDP2 Gene

Localization for PDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDP2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDP2 Gene COMPARTMENTS Subcellular localization image for PDP2 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PDP2: view

Pathways for PDP2 Gene

genes like me logo Genes that share pathways with PDP2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006470 protein dephosphorylation --
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS --
GO:0035970 peptidyl-threonine dephosphorylation IEA --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with PDP2: view

Compounds for PDP2 Gene

(5) HMDB Compounds for PDP2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Hydrogen phosphate
  • Biphosphate
14066-19-4
Magnesium
  • Magnesium
7439-95-4
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with PDP2: view

Transcripts for PDP2 Gene

Unigene Clusters for PDP2 Gene

Pyruvate dehyrogenase phosphatase catalytic subunit 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g
SP1:
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -

Relevant External Links for PDP2 Gene

GeneLoc Exon Structure for
PDP2
ECgene alternative splicing isoforms for
PDP2

Expression for PDP2 Gene

mRNA expression in normal human tissues for PDP2 Gene

Protein differential expression in normal tissues for PDP2 Gene

This gene is overexpressed in Lung (43.7) and Breast (24.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDP2 Gene

SOURCE GeneReport for Unigene cluster for PDP2 Gene Hs.632214

genes like me logo Genes that share expressions with PDP2: view

Expression partners for PDP2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PDP2 Gene

Orthologs for PDP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDP2 35
  • 87.12 (n)
  • 87.5 (a)
PDP2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDP2 35
  • 88.34 (n)
  • 88.47 (a)
PDP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdp2 35
  • 83.27 (n)
  • 85.74 (a)
Pdp2 16
Pdp2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDP2 35
  • 99.43 (n)
  • 99.81 (a)
PDP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdp2 35
  • 83.49 (n)
  • 83.93 (a)
oppossum
(Monodelphis domestica)
Mammalia PDP2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDP2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDP2 35
  • 65.4 (n)
  • 66.1 (a)
PDP2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDP2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdp2 35
  • 63.46 (n)
  • 59.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17333 35
zebrafish
(Danio rerio)
Actinopterygii pdp2 35
  • 62.07 (n)
  • 60.22 (a)
pdp2 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pdp 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pdp-1 36
  • 35 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL083C 35
  • 46.63 (n)
  • 36.52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13706g 35
  • 45.27 (n)
  • 37.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC5 35
  • 46.34 (n)
  • 36.47 (a)
PTC5 36
  • 23 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01767 35
  • 46.12 (n)
  • 36.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.17c 35
  • 45.7 (n)
  • 37.39 (a)
Species with no ortholog for PDP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDP2 Gene

ENSEMBL:
Gene Tree for PDP2 (if available)
TreeFam:
Gene Tree for PDP2 (if available)

Paralogs for PDP2 Gene

Paralogs for PDP2 Gene

Selected SIMAP similar genes for PDP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PDP2: view

Variants for PDP2 Gene

Sequence variations from dbSNP and Humsavar for PDP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs149156 -- 66,878,803(-) ATTCC(A/G)GTGAT upstream-variant-2KB
rs152169 -- 66,879,736(+) gagcc(C/T)ggcag upstream-variant-2KB
rs152170 -- 66,879,250(-) gtctc(A/G)ctctg upstream-variant-2KB
rs152171 -- 66,879,212(-) atctc(C/G)gctca upstream-variant-2KB
rs152172 -- 66,879,002(+) gctca(C/T)gcctg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PDP2 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294

Relevant External Links for PDP2 Gene

HapMap Linkage Disequilibrium report
PDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDP2 Gene

Disorders for PDP2 Gene

Relevant External Links for PDP2

Genetic Association Database (GAD)
PDP2
Human Genome Epidemiology (HuGE) Navigator
PDP2

No disorders were found for PDP2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PDP2 Gene

Publications for PDP2 Gene

  1. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. (PMID: 9651365) Huang B. … Popov K.M. (J. Biol. Chem. 1998) 2 3
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. (PMID: 20525856) La Gerche A. … HeidbA1chel H. (Heart 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for PDP2 Gene

Sources for PDP2 Gene

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