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PDP2 Gene

protein-coding   GIFtS: 56
GCID: GC16P066914

Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 21 2     PPM2C22
Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 22 3     [Pyruvate Dehydrogenase [Acetyl-Transferring]]-Phosphatase 2,
Mitochondrial2
PDPC 22 3     Protein Phosphatase 2C, Magnesium-Dependent, Catalytic Subunit 22
EC 3.1.3.433 8     Pyruvate Dehydrogenase Phosphatase Isoenzyme 22
KIAA13483 5     Pyruvate Dehydrogenase Phosphatase, Catalytic Subunit 22
Catalytic Subunit 21     PDP 23
magnesium-dependent1     EC 3.1.38
Protein Phosphatase 2C1     

External Ids:    HGNC: 302631   Entrez Gene: 575462   Ensembl: ENSG000001728407   OMIM: 6154995   UniProtKB: Q9P2J93   

Export aliases for PDP2 gene to outside databases

Previous GC identifers: GC16P066690 GC16P065471 GC16P052788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PDP2 Gene:
PDP2 (pyruvate dehyrogenase phosphatase catalytic subunit 2) is a protein-coding gene. Diseases associated with PDP2 include insulin resistance, and obesity. GO annotations related to this gene include [pyruvate dehydrogenase (lipoamide)] phosphatase activity and magnesium-dependent protein serine/threonine phosphatase activity. An important paralog of this gene is PDP1.

UniProtKB/Swiss-Prot: PDP2_HUMAN, Q9P2J9
Function: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of
the pyruvate dehydrogenase complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDP2 gene promoter:
         C/EBPbeta   USF1   AML1a   Tal-1beta   USF-1   STAT3   ZIC2/Zic2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDP2 promoter sequence
   Search Chromatin IP Primers for PDP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

PDP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066914:  view genomic region     (about GC identifiers)

Start:
66,912,492 bp from pter      End:
66,929,657 bp from pter
Size:
17,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDP2_HUMAN, Q9P2J9 (See protein sequence)
Recommended Name: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor  
Size: 529 amino acids; 59978 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Heterodimer of a catalytic subunit and a FAD protein of unknown function (By similarity)
Sequence caution: Sequence=BAA92586.1; Type=Erroneous initiation;
Secondary accessions: A8K924

Explore the universe of human proteins at neXtProt for PDP2: NX_Q9P2J9

Explore proteomics data for PDP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys438, Lys459
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDP2 (Q9P2J9) (see all 5)
     LASDGLW  VAFSGATAC  ARMYRDDIT  QAVSERLFYY 


    See PDP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065837.1  
    ENSEMBL proteins: 
     ENSP00000457331   ENSP00000309548   ENSP00000456611   ENSP00000457951   ENSP00000456171  
     ENSP00000457675   ENSP00000455975  
    Reactome Protein details: Q9P2J9

    PDP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PDP2
    OriGene Protein Over-expression Lysate for PDP2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PDP2
    GenScript Custom Purified and Recombinant Proteins Services for PDP2
    Novus Biologicals PDP2 Protein
    Novus Biologicals PDP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDP2

    PDP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals PDP2 Antibodies
    Abcam antibodies for PDP2
    Cloud-Clone Corp. Antibodies for PDP2
    Search ThermoFisher Antibodies for PDP2
    LSBio Antibodies in human, mouse, rat for PDP2

    PDP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PDP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDP2
    Cloud-Clone Corp. CLIAs for PDP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    3 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR000222 PP2C_Mn2_Asp60_BS
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry Q9P2J9

    ProtoNet protein and cluster: Q9P2J9

    UniProtKB/Swiss-Prot: PDP2_HUMAN, Q9P2J9
    Similarity: Belongs to the PP2C family


    PDP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDP2_HUMAN, Q9P2J9
    Function: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of
    the pyruvate dehydrogenase complex (By similarity)
    Catalytic activity: [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase
    (acetyl-transferring)] + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.431 2 EC 3.1.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004722protein serine/threonine phosphatase activity ----
    GO:0004724magnesium-dependent protein serine/threonine phosphatase activity IEA--
    GO:0004741[pyruvate dehydrogenase (lipoamide)] phosphatase activity IEA--
    GO:0046872metal ion binding IEA--
         
    PDP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDP2:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDP2:
    hsa-let-7e-5p (MIRT051639), hsa-let-7b-5p (MIRT052354)

    Block miRNA regulation of human, mouse, rat PDP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDP2 (see all 55):
    hsa-let-7d hsa-miR-4328 hsa-miR-513a-5p hsa-miR-29a hsa-miR-128 hsa-miR-374a hsa-miR-30d hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidPDP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDP2
    Predesigned siRNA for gene silencing in human, mouse, rat PDP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDP2

    Clone
    Products:
         
    OriGene clones in human, mouse for PDP2 (see all 6)
    OriGene ORF clones in mouse, rat for PDP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDP2 (NM_020786)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDP2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PDP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDP2_HUMAN, Q9P2J9: Mitochondrion matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--

    PDP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    Pyruvate metabolism0.00
    Regulation of pyruvate dehydrogenase (PDH) complex0.00
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PDP2
        Regulation of pyruvate dehydrogenase (PDH) complex



    PDP2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDP2: 
              Protein Phosphatases in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PDP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDP2 (Q9P2J93 ENSP000003095484) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    EIF6P565373I2D: score=4 
    HSP90AA1P079003I2D: score=3 
    NAP1L4Q997333I2D: score=3 
    UTP18Q9Y5J13I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0006470protein dephosphorylation ----
    GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate TAS--
    GO:0035970peptidyl-threonine dephosphorylation IEA--
    GO:0044237cellular metabolic process TAS--

    PDP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDP2

    5 HMDB Compounds for PDP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydrogen phosphateBiphosphate (see all 10)14066-19-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PDP2 gene: 
    NM_020786.2  

    Unigene Cluster for PDP2:

    Pyruvate dehyrogenase phosphatase catalytic subunit 2
    Hs.632214  [show with all ESTs]
    Unigene Representative Sequence: NM_020786
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566543 ENST00000311765(uc002eqk.2) ENST00000568869 ENST00000561704
    ENST00000568398 ENST00000566805 ENST00000568720 ENST00000566776
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDP2 (see all 55):
    hsa-let-7d hsa-miR-4328 hsa-miR-513a-5p hsa-miR-29a hsa-miR-128 hsa-miR-374a hsa-miR-30d hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidPDP2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat PDP2
    Clone
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    OriGene clones in human, mouse for PDP2 (see all 6)
    OriGene ORF clones in mouse, rat for PDP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDP2 (NM_020786)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDP2
    OriGene qSTAR qPCR primer pairs in human, mouse for PDP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDP2
      QuantiTect SYBR Green Assays in human, mouse, rat PDP2
      QuantiFast Probe-based Assays in human, mouse, rat PDP2

    Additional mRNA sequence: 

    AB037769.1 AK098273.1 AK292539.1 BC028030.1 

    5 DOTS entries:

    DT.213102  DT.75171610  DT.97762984  DT.97796901  DT.91693022 

    Selected AceView cDNA sequences (see all 86):

    BM792339 BQ940320 AA478547 AA478546 BF432080 AA448017 BM668681 AI077514 
    CB122816 BF447852 BU192644 BM693406 BQ650052 BM716425 BU735208 AI569451 
    BF437046 W74797 NM_020786 AW001053 BC028030 AI088045 AW083689 AI076867 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDP2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g
    SP1:                                                                                                      
    SP2:                                      -     -     -     -                                             
    SP3:                                            -     -     -                                             
    SP4:                                      -     -     -     -     -                                       
    SP5:                                                        -                                             


    ECgene alternative splicing isoforms for PDP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTATCAG
    PDP2 Expression
    About this image

    PDP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632214
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDP2: 
              Protein Phosphatases in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDP2
    OriGene qSTAR qPCR primer pairs in human, mouse for PDP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDP2
    QuantiTect SYBR Green Assays in human, mouse, rat PDP2
    QuantiFast Probe-based Assays in human, mouse, rat PDP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDP2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdp21 , 5 pyruvate dehyrogenase phosphatase catalytic subunit more1, 5 83.27(n)1
    85.74(a)1
      8 (53.04 cM)5
    3820511  NM_001024606.11  NP_001019777.11 
     1045914685 
    chicken
    (Gallus gallus)
    Aves PDP21 pyruvate dehyrogenase phosphatase catalytic subunit more 65.4(n)
    66.1(a)
      427550  XM_004944246.1  XP_004944303.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDP26
    pyruvate dehyrogenase phosphatase catalytic subuni...
    61(a)
    1 ↔ 1
    GL343295.1(226543-228366)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173332 Xenopus laevis transcribed sequence with weak similarity more 79.05(n)    BJ062609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdp22 putative pyruvate dehydrogenase phosphatase isoenzyme more 73.51(n)   58149  AF294839.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pdp6
    Pyruvate dehydrogenase phosphatase
    38(a)
    1 → many
    X(7625809-7628730)
    worm
    (Caenorhabditis elegans)
    Secernentea pdp-16
    Protein PDP-1 (pdp-1) mRNA, complete cds
    35(a)
    1 → many
    I(4368089-4370504) WBGene00022832
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTC51 PTC5 46.34(n)
    36.47(a)
      854257   NP_014733.1 


    ENSEMBL Gene Tree for PDP2 (if available)
    TreeFam Gene Tree for PDP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDP2 gene
    PDP12  
    2 SIMAP similar genes for PDP2 using alignment to 7 protein entries:     PDP2_HUMAN (see all proteins):
    PDP1    PPM2C

    PDP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDP2 (see all 267)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844728771,2
    --66912533(+) GGCCAA/GGCTGC 1 -- us2k10--------
    rs1521731,2
    C,F,H--66912552(+) GCCAGT/GGTGTC 1 -- us2k126Minor allele frequency- G:0.30NS EA NA WA CSA 2353
    rs1478186371,2
    --66912557(+) GGTGTC/TTTCCT 1 -- us2k10--------
    rs1491561,2
    C,F,O,H--66912706(-) ATTCCG/AGTGAT 1 -- us2k125Minor allele frequency- A:0.30MN NS EA NA WA CSA 2532
    rs1873525061,2
    --66912794(+) CCAGCC/TGTGCT 1 -- us2k10--------
    rs1395837591,2
    --66912836(+) GGTCAA/GTTCAA 1 -- us2k10--------
    rs1521721,2
    C,F--66912905(+) gctcaT/Cgcctg 1 -- us2k14Minor allele frequency- C:0.25NA 8
    rs99403051,2
    C--66913149(+) gcgacG/Agagcg 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs4475141,2
    C--66913230(-) aaaaCA/CAACCA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1419139931,2
    C--66913450(+) CCAGGA/CTGGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDP2 (66912492 - 66929657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PDP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2885n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615499    OMIM disorders: --

    2 diseases for PDP2:    
    About MalaCards
    insulin resistance    obesity


    PDP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PDP2
    Human Genome Epidemiology (HuGE) Navigator: PDP2 (3 documents)

    Export disorders for PDP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDP2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with PDP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. (PubMed id 20525856)1, 4 La Gerche A....HeidbA1chel H. (Heart 2010)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. (PubMed id 9651365)1, 3 Huang B....Popov K.M. (J. Biol. Chem. 1998)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)
    8. Crystallization and preliminary crystallographic studies of the catalytic subunits of human pyruvate dehydrogenase phosphatase isoforms 1 and 2. (PubMed id 20208177)1 Kato J. and Kato M. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 57546 HGNC: 30263 AceView: PDP2 Ensembl:ENSG00000172840 euGenes: HUgn57546
    ECgene: PDP2 H-InvDB: PDP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1348

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PDP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PDP2 gene:
    Search GeneIP for patents involving PDP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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