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Aliases for PDP2 Gene

Aliases for PDP2 Gene

  • Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 2 2 3 5
  • Protein Phosphatase 2C, Magnesium-Dependent, Catalytic Subunit 2 2 3
  • Protein Phosphatase, Mg2+/Mn2+ Dependent 2B 2 3
  • EC 3.1.3.43 4 61
  • PDPC 2 3 4
  • [Pyruvate Dehydrogenase [Acetyl-Transferring]]-Phosphatase 2, Mitochondrial 3
  • Pyruvate Dehydrogenase [Acetyl-Transferring]-Phosphatase 2, Mitochondrial 3
  • [Pyruvate Dehydrogenase (Acetyl-Transferring)]-Phosphatase 2
  • Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 4
  • Pyruvate Dehydrogenase Phosphatase Isoenzyme 2 3
  • KIAA1348 4
  • EC 3.1.3 61
  • PPM2C2 3
  • PPM2B 3
  • PDP 2 4

External Ids for PDP2 Gene

Previous GeneCards Identifiers for PDP2 Gene

  • GC16P066690
  • GC16P065471
  • GC16P066914
  • GC16P052788

Summaries for PDP2 Gene

Entrez Gene Summary for PDP2 Gene

  • This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]

GeneCards Summary for PDP2 Gene

PDP2 (Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 2) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein serine/threonine phosphatase activity and magnesium-dependent protein serine/threonine phosphatase activity. An important paralog of this gene is PDP1.

UniProtKB/Swiss-Prot for PDP2 Gene

  • Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDP2 Gene

Genomics for PDP2 Gene

Regulatory Elements for PDP2 Gene

Enhancers for PDP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066585 1.3 FANTOM5 Ensembl 9.8 -291.6 -291618 2.9 ATF1 PKNOX1 FEZF1 GLIS2 ZNF766 FOS JUNB ZNF518A ZNF592 GLIS1 BEAN1 TK2 CKLF PDP2 LINC00920 ENSG00000260650 CMTM3
GH16G066616 1.3 Ensembl ENCODE 9.8 -260.1 -260055 4.4 PKNOX1 FOXA2 ARNT SIN3A ARID4B DMAP1 FEZF1 ZNF2 YY1 ZNF766 BEAN1 TK2 PDP2 CMTM4 PIR38551 PIR36038 GC16M066618
GH16G066871 1.6 FANTOM5 ENCODE 3.2 -4.7 -4749 5.1 CREB3L1 MLX FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 E2F4 CES2 CA7 PLEKHG4 ZDHHC1 KIAA0895L CENPT ENSG00000260465 FAM96B FBXL8
GH16G066879 1.1 ENCODE 0.7 +2.2 2184 2.0 PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF416 CES2 ENSG00000260465 CDH16 RRAD ZDHHC1 FAM96B CENPT CA7 B3GNT9 THAP11
GH16G066877 1 Ensembl ENCODE 0.7 -0.5 -489 0.6 LEF1 ETV1 ZNF223 CEBPG THRB ZFHX2 EED PATZ1 NR2F6 IKZF2 CA7 CES2 FAM96B NAE1 PDP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDP2 Gene

Chromosome:
16
Start:
66,878,589 bp from pter
End:
66,895,754 bp from pter
Size:
17,166 bases
Orientation:
Plus strand

Genomic View for PDP2 Gene

Genes around PDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDP2 Gene

Proteins for PDP2 Gene

  • Protein details for PDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J9-PDP2_HUMAN
    Recommended name:
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
    Protein Accession:
    Q9P2J9
    Secondary Accessions:
    • A8K924

    Protein attributes for PDP2 Gene

    Size:
    529 amino acids
    Molecular mass:
    59978 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimer of a catalytic subunit and a FAD protein of unknown function.
    SequenceCaution:
    • Sequence=BAA92586.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PDP2 Gene

Selected DME Specific Peptides for PDP2 Gene

Q9P2J9:
  • LASDGLW
  • ARMYRDDIT
  • PEVTYHRLRPQDKFLVLA
  • QAVSERLFYY
  • VAFSGATAC

Post-translational modifications for PDP2 Gene

  • Ubiquitination at posLast=438438 and Lys459
  • Modification sites at PhosphoSitePlus

Domains & Families for PDP2 Gene

Gene Families for PDP2 Gene

Protein Domains for PDP2 Gene

Suggested Antigen Peptide Sequences for PDP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2J9

UniProtKB/Swiss-Prot:

PDP2_HUMAN :
  • Belongs to the PP2C family.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PDP2: view

Function for PDP2 Gene

Molecular function for PDP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

Enzyme Numbers (IUBMB) for PDP2 Gene

Gene Ontology (GO) - Molecular Function for PDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity EXP 9651365
GO:0016787 hydrolase activity IEA --
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with PDP2: view
genes like me logo Genes that share phenotypes with PDP2: view

Animal Model Products

miRNA for PDP2 Gene

miRTarBase miRNAs that target PDP2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDP2 Gene

Localization for PDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDP2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDP2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PDP2: view

Pathways & Interactions for PDP2 Gene

genes like me logo Genes that share pathways with PDP2: view

SIGNOR curated interactions for PDP2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS --
genes like me logo Genes that share ontologies with PDP2: view

Drugs & Compounds for PDP2 Gene

(4) Drugs for PDP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Nutra 0

(2) Additional Compounds for PDP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen phosphate
  • Biphosphate
  • Hydrogen orthophosphate
  • Hydrogen phosphate
  • Hydrogen phosphate anion
  • Hydrogen phosphate dianion
14066-19-4
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with PDP2: view

Transcripts for PDP2 Gene

Unigene Clusters for PDP2 Gene

Pyruvate dehyrogenase phosphatase catalytic subunit 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g
SP1:
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -

Relevant External Links for PDP2 Gene

GeneLoc Exon Structure for
PDP2
ECgene alternative splicing isoforms for
PDP2

Expression for PDP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDP2 Gene

This gene is overexpressed in Lung (43.7) and Breast (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDP2 Gene



Protein tissue co-expression partners for PDP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDP2 Gene:

PDP2

SOURCE GeneReport for Unigene cluster for PDP2 Gene:

Hs.632214

Evidence on tissue expression from TISSUES for PDP2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PDP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDP2 Gene

Orthologs for PDP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDP2 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia PDP2 34 35
  • 88.34 (n)
cow
(Bos Taurus)
Mammalia PDP2 34 35
  • 87.12 (n)
rat
(Rattus norvegicus)
Mammalia Pdp2 34
  • 83.49 (n)
mouse
(Mus musculus)
Mammalia Pdp2 34 16 35
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia PDP2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDP2 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDP2 34 35
  • 65.4 (n)
lizard
(Anolis carolinensis)
Reptilia PDP2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdp2 34
  • 63.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17333 34
zebrafish
(Danio rerio)
Actinopterygii pdp2 34 35
  • 62.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pdp 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pdp-1 35
  • 35 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL083C 34
  • 46.63 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC5 35 34
  • 46.34 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13706g 34
  • 45.27 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01767 34
  • 46.12 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.17c 34
  • 45.7 (n)
Species where no ortholog for PDP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDP2 Gene

ENSEMBL:
Gene Tree for PDP2 (if available)
TreeFam:
Gene Tree for PDP2 (if available)

Paralogs for PDP2 Gene

Paralogs for PDP2 Gene

(2) SIMAP similar genes for PDP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PDP2: view

Variants for PDP2 Gene

Sequence variations from dbSNP and Humsavar for PDP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs193921129 Uncertain significance 66,885,174(+) GGACA(A/G)TGGCA reference, missense
rs1000429102 -- 66,882,296(+) CTGGG(A/C)CTGGC intron-variant
rs1000481657 -- 66,882,589(+) AATAT(C/T)CCCAT intron-variant
rs1000765762 -- 66,883,713(+) AAAGT(G/T)CTAGG intron-variant
rs1000831915 -- 66,891,573(+) AGGAT(A/T)TGAAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PDP2 Gene

Variant ID Type Subtype PubMed ID
nsv572904 CNV loss 21841781

Variation tolerance for PDP2 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDP2 Gene

Disorders for PDP2 Gene

Relevant External Links for PDP2

Genetic Association Database (GAD)
PDP2
Human Genome Epidemiology (HuGE) Navigator
PDP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDP2

No disorders were found for PDP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDP2 Gene

Publications for PDP2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  4. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. (PMID: 9651365) Huang B. … Popov K.M. (J. Biol. Chem. 1998) 2 3 64
  5. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3 64

Products for PDP2 Gene

Sources for PDP2 Gene

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