PDLIM7 Gene
protein-coding GIFtS: 55
GCID: GC05M176912
|
|
PDZ and LIM domain 7 (enigma)
| |
Aliases
for PDLIM7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PDZ And LIM Domain 7 (Enigma)1 2 | | LMP32 | | ENIGMA1 3 5 | | LIM Domain Protein2 | | Protein Enigma2 3 | | Lim Mineralization Protein 32 | | LMP2 3 | | PDZ And LIM Domain Protein 72 | | 1110003B01Rik2 | | LIM Mineralization Protein3 | | LMP12 | | |
Export aliases for PDLIM7 gene to outside databasesPrevious GC identifers: GC00U914366 GC05M177024 GC05M176843 GC05M171830 |
Summaries
for PDLIM7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PDLIM7:
The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains.LIM domains are proposed to function in protein-protein recognition in a variety of contexts including genetranscription and development and in cytoskeletal interaction. The LIM domains of this protein bind to proteinkinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actinfilament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function islikely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of bothskeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PDLI7_HUMAN, Q9NR12Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as anadapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle andnonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g.embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development).Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)
Gene Wiki entry for PDLIM7
|
Genomic Views
for PDLIM7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDLIM7 gene promoter:
E2F-3a E2F-1 E2F AP-1 E2F-2 IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDLIM7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDLIM7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3PDLIM7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M176912: view genomic region
(about GC identifiers)
Start:
|
176,910,395 bp from pter |
End:
|
176,924,607 bp from pter |
Size:
|
14,213 bases |
Orientation:
|
minus strand |
|
Proteins
for PDLIM7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDLI7_HUMAN, Q9NR12 (See
protein sequence)Recommended Name: PDZ and LIM domain protein 7 Size: 457 amino acids; 49845 Da
Subunit: Binds via its LIM zinc-binding 3 domain (LIM 3) to endocytic codes of INSR, but not with those of IGF1R, LDLR,TFRC, or EGFR. Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in aphosphorylation-independent manner via its LIM zinc-binding domain 2 (LIM 2). Probably part of a complex with SHC andthe RET dimer. Interacts with TPM2. Interacts with TBX4 and TBX5 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with RET tothe cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Co-localizeswith TBX4 and TBX5 to actin filaments (By similarity)
Sequence caution: Sequence=AAC37565.1; Type=Frameshift; Positions=103, 128, 161, 183, 195, 245;
1 PDB 3D structure from  and Proteopedia  for PDLIM7:2Q3G (3D)
Secondary accessions: Q14250 Q5XG82 Q6NVZ5 Q96C91 Q9BXB8 Q9BXB9Alternative splicing: 6 isoforms: Q9NR12-1 Q9NR12-2 Q9NR12-3 Q9NR12-4 Q9NR12-5 Q9NR12-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PDLIM7: NX_Q9NR12
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NR12
PDLIM7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_005442.2 NP_976227.1 NP_998801.1
ENSEMBL proteins: ENSP00000431236 ENSP00000352964 ENSP00000348099 ENSP00000439157 ENSP00000377182 ENSP00000426213 ENSP00000347776 ENSP00000377177 ENSP00000424850 ENSP00000422363 ENSP00000421664 ENSP00000349030
Human Recombinant Protein Products for PDLIM7:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
PDLIM7 for ontologies About GeneDecksing
PDLIM7 Antibody Products:
Assay Products for PDLIM7: |
Protein
Domains /
Families
for PDLIM7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDLIM7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NR12ProtoNet protein and cluster: Q9NR12 2 Blocks protein families: IPB001478 PDZ/DHR/GLGF domain IPB001781 Zn-binding protein
UniProtKB/Swiss-Prot: PDLI7_HUMAN, Q9NR12Domain: The LIM zinc-binding 2 (LIM 2) domain interacts with TBX4 (By similarity)Domain: The LIM zinc-binding 3 (LIM 3) domain provides the structural basis for recognition of tyrosine-containingtight turn structures. This domain is necessary and sufficient for interaction with TBX5 (By similarity)Domain: Anchored to cell periphery via its N-terminal PDZ domainSimilarity: Contains 3 LIM zinc-binding domainsSimilarity: Contains 1 PDZ (DHR) domain |
Function
for PDLIM7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PDLI7_HUMAN, Q9NR12Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as anadapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle andnonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g.embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development).Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
PDLIM7 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM7 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM7 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PDLIM7 (NM_213636) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDLIM7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDLIM7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM7 |
|
Pathways & Interactions
for PDLIM7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development EGFR signaling pathway | | | 2 | EBV LMP1 signaling | | | 3 | Signaling events regulated by Ret tyrosine kinase | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PDLIM7
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PDLIM7
1  GeneGo (Thomson Reuters) Pathway for PDLIM7
2  BioSystems Pathways for PDLIM7
PDLIM7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDLIM7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/788 Interacting proteins for PDLIM7 (Q9NR121, 2, 3 ENSP000003480994) via UniProtKB, MINT, STRING, and/or I2D (see all 788)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
PDLIM7 for ontologies About GeneDecksing
|
Drugs & Compounds
for PDLIM7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PDLIM7
Search CenterWatch for drugs/clinical trials and news about PDLIM7 / PDLI7
|
Transcripts
for PDLIM7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDLIM7 gene (4 alternative transcripts): NM_005451.3 NM_203352.1 NM_213636.1 NM_203353.1 Unigene Cluster for PDLIM7: PDZ and LIM domain 7 (enigma) Hs.533040 [show with all ESTs]Unigene Representative Sequence: AK09682617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493815 ENST00000359895 ENST00000355841 ENST00000486828(uc003mha.1 uc003mhb.1 uc003mhc.1 uc003mhd.1 uc003mhe.1)
ENST00000504380 ENST00000505746 ENST00000393551(uc003mhf.3) ENST00000505074
ENST00000355572(uc003mhg.1) ENST00000393546 ENST00000506161 ENST00000504318
ENST00000503346 ENST00000503827 ENST00000463411 ENST00000506537 ENST00000356618
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM7 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM7 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PDLIM7 (NM_213636) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDLIM7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDLIM7 |
Additional cDNA sequence: AF265209.1 AF345904.1 AF345905.1 AK096826.1 BC001093.2 BC007648.1 BC014521.2 BC023629.2 BC084575.1 DQ291143.1 24 DOTS entries: DT.85105616 DT.91896419 DT.120862389 DT.92443476 DT.102839668 DT.91854702 DT.100894868 DT.120862440 DT.91714237 DT.97854788 DT.100030242 DT.97854787 DT.100811139 DT.100811141 DT.100727135 DT.97813779 DT.120862455 DT.95085177 DT.95085210 DT.120862462 DT.100811148 DT.86856066 DT.92443473 DT.121623182 24/403 AceView cDNA sequences (see all 403): AI805049 BM704945 AI042224 BQ674388 BM559240 BC014521 BM010685 BI823961 BE962818 AI468267 AW978360 AA295228 BF003106 AI817730 BQ936363 F24196 BU857511 BQ923519 BU957750 BM695955 BE646284 BI826556 CD675254 BQ929859
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM7 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | | | | | | | | | - | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | - | | |
| SP3: | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12a | · | 12b | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | - | | | | | | | | |
| SP2: | - | | | | | | | | |
| SP3: | - | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for PDLIM7
|
Expression
for PDLIM7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDLIM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGAGCCCC
About this image
See PDLIM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDLIM7
SOURCE GeneReport for Unigene cluster: Hs.533040
UniProtKB/Swiss-Prot: PDLI7_HUMAN, Q9NR12Tissue specificity: Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletalmuscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver
SABiosciences Expression via Pathway-Focused PCR Array including PDLIM7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDLIM7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PDLIM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDLIM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDLIM7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM7 |
Orthologs
for PDLIM7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PDLIM7 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pdlim71 , 5 |
PDZ and LIM domain 71, 5 |
88.4(n)1
93.87(a)1 |
|
13 (30.06 cM)5
673991 NM_001114088.11 NP_001107560.11
554957955 |
chicken
(Gallus gallus) |
Aves |
PDLIM71 |
PDZ and LIM domain 7 (enigma) |
75.68(n)
75.6(a) |
|
416362 NM_001005345.1 NP_001005345.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PDLIM76 |
-- |
77(a) |
1 ↔ 1 |
2(145663551-145710055) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.157172 |
Transcribed sequence with weak similarity to protein more |
79.81(n) |
|
AL848905.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc659072 |
hypothetical protein MGC65907 |
76.79(n) |
|
393813 BC061704.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Zasp526 |
Z band alternatively spliced PDZ-motif protein 52 |
6(a) |
1 → many |
2R(11650070-11704509) |
worm
(Caenorhabditis elegans) |
Secernentea |
alp-16 |
ALP/Enigma encoding family member (alp-1) |
9(a) |
1 → many |
IV(8852485-8862474) |
ENSEMBL Gene Tree for PDLIM7 (if available)
TreeFam Gene Tree for PDLIM7 (if available) |
Paralogs
for PDLIM7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PDLIM7 gene
- ABLIM32 LIMS12 LIMS3L2 FHL52 LDB32 LPXN2 ABLIM22 PDLIM52
- ENSG000002572072 LIMS22 FHL22 ABLIM12 EPB492 FHL32 FHL12 TGFB1I12
- LIMS32 PXN2
11 SIMAP similar genes for PDLIM7 using alignment to 6 protein entries: PDLI7_HUMAN (see all proteins):PDLIM3 PDLIM5 SYNPO2 LDB3 PDLIM2 SLC9A3R1
SNTG1 USH1C MAGI1 SCRIB GRIP1
PDLIM7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PDLIM7
PGOHUM00000249601
|
Genomic Variants
for PDLIM7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDLIM7 (176910395 - 176924607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDLIM7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDLIM7 |
|
Disorders
/ Diseases
for PDLIM7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDLIM7 for disorders About GeneDecksing
OMIM gene information: 605903
OMIM disorders: --
18  diseases for PDLIM7: About MalaCardsdental pulp calcification human immunodeficiency virus infectious disease hemophagocytic lymphohistiocytosis pleural empyema
non-hodgkin lymphoma composite lymphoma infectious mononucleosis reticulosarcoma
hodgkin's lymphoma nasopharynx carcinoma burkitt's lymphoma multiple sclerosis
periodontitis nasopharyngitis immunodeficiency ataxia
carcinoma cns lymphoma
4 diseases from the University of Copenhagen DISEASES database for PDLIM7:Nasopharynx carcinoma Lymphoma Infectious mononucleosis Pleural empyema Export disorders for PDLIM7 gene to outside databases
|
Publications
for PDLIM7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDLIM7 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with PDLIM7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Overexpressed LIM mineralization proteins do not require LIM domains to induce bone. (PubMed id 11874232)1, 2, 3 Liu Y.... Titus L. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. (PubMed id 10359609)1, 2 Guy P.M.... Gill G.N. (1999)
- Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. (PubMed id 9528800)1, 2 Durick K.... Taylor S.S. (1998)
- Protein-protein interaction of zinc finger LIM domains with protein kinase C. (PubMed id 8940095)1, 2 Kuroda S.... Kikkawa U. (1996)
- LIM domain recognition of a tyrosine-containing tight turn. (PubMed id 7929196)1, 2 Wu R.-Y. and Gill G.N. (1994)
- Modeling and analysis of molecularinteraction between Smurf1-WW2 domain and various isoforms of LIM mineralization protein. (PubMed id 17510966)1, 9 Sangadala S....Reddy B.V. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Lim mineralization protein 3 induces the osteogenic di fferentiation of human amniotic fluid stromal cells through Kruppel-like factor- 4 downregulation and further bone-specific gene expression. (PubMed id 23097599)1 Barba M....Lattanzi W. (2012)
- Epstein-Barr virus-encoded LMP1 triggers regulation of the ERK-mediated Op18/stathmin signaling pathway in association with cell cycle . (PubMed id 22417000)1 Lin X....Cao Y. (2012)
|
External Searches for PDLIM7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PDLIM7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PDLIM7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDLIM7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PDLIM7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PDLIM7 gene:
Search GeneIP for patents involving PDLIM7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PDLIM7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PDLIM7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDLIM7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDLIM7 | | | OriGene Protein Over-expression Lysate for PDLIM7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDLIM7 | | OriGene 3'-UTR Clone for PDLIM7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PDLIM7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PDLIM7 | | OriGene Custom Protein Services for PDLIM7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDLIM7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDLIM7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDLIM7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDLIM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDLIM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDLIM7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PDLIM7 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PDLIM7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM7 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PDLIM7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDLIM7 |
| |  | |
|
|
|
