Aliases for PDLIM5 Gene
External Ids for PDLIM5 Gene
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for PDLIM5 Gene
PDLIM5 (PDZ And LIM Domain 5) is a Protein Coding gene. Diseases associated with PDLIM5 include nail-patella syndrome and barth syndrome. GO annotations related to this gene include actin binding and actinin binding. An important paralog of this gene is LDB3.
UniProtKB/Swiss-Prot for PDLIM5 Gene
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).