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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDLIM3 Gene

protein-coding   GIFtS: 54
GCID: GC04M186422

PDZ and LIM domain 3
 Explore 29 diseases affiliated with
PDLIM3 via
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Biological research products
for PDLIM3    

Aliases
for PDLIM3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
PDZ And LIM Domain 31 2
ALP1 2 3 5
Alpha-Actinin-2-Associated LIM Protein2 3
Enigma Homolog2
PDZ And LIM Domain Protein 32
Actinin-Associated LIM Protein3

External Ids:    HGNC: 207671   Entrez Gene: 272952   Ensembl: ENSG000001545537   OMIM: 6058895   UniProtKB: Q53GG53   

Export aliases for PDLIM3 gene to outside databases

Previous GC identifers: GC04M187118 GC04M186798 GC04M186659 GC04M182175


Summaries
for PDLIM3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDLIM3:
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in
cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of
alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this
gene may play a role in myotonic dystrophy. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: PDLI3_HUMAN, Q53GG5
Function: May play a role in the organization of actin filament arrays within muscle cells (By similarity)

Gene Wiki entry for PDLIM3


Genomic Views
for PDLIM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDLIM3 gene promoter:
         TBP   Nkx2-5   Cdc5   C/EBPalpha   AREB6   MZF-1   GATA-6   TFIID   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDLIM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDLIM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDLIM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35

PDLIM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDLIM3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M186422:  view genomic region     (about GC identifiers)

Start:
 186,421,814 bp from pter      End:
 186,456,766 bp from pter
Size:
 34,953 bases      Orientation:
 minus strand

Proteins
for PDLIM3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDLI3_HUMAN, Q53GG5 (See protein sequence)
Recommended Name: PDZ and LIM domain protein 3  
Size: 364 amino acids; 39232 Da
Subunit: Interacts with ACTN2 (By similarity)
Subcellular location: Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines
Secondary accessions: B2R866 O43590 O60439 O60440 Q8N6Y6 Q9BVP4
Alternative splicing: 3 isoforms:  Q53GG5-1   Q53GG5-2   Q53GG5-3   

Explore the universe of human proteins at neXtProt for PDLIM3: NX_Q53GG5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53GG5

    • PDLIM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001107579.1  NP_001244891.1  NP_001244892.1  NP_055291.2  

    ENSEMBL proteins: 
     ENSP00000284770   ENSP00000284771   ENSP00000425138   ENSP00000421972   ENSP00000284767  

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    OriGene Protein Over-expression Lysate: PDLIM3
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    Novus Biologicals PDLIM3 Protein
    Novus Biologicals PDLIM3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PDLIM3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015629actin cytoskeleton IEA--
    GO:0030018Z disc IEA--


    PDLIM3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PDLIM3

    Protein Domains /
    Families
    for PDLIM3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDLIM3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006643 ZASP
     IPR001478 PDZ
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q53GG5

    ProtoNet protein and cluster: Q53GG5

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: PDLI3_HUMAN, Q53GG5
    Similarity: Contains 1 LIM zinc-binding domain
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for PDLIM3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDLI3_HUMAN, Q53GG5
    Function: May play a role in the organization of actin filament arrays within muscle cells (By similarity)

    miRNA
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    hsa-miR-4311 hsa-miR-634 hsa-miR-137 hsa-miR-186* hsa-miR-409-3p hsa-miR-629* hsa-miR-518a-5p hsa-miR-4323
    SwitchGear 3'UTR luciferase reporter plasmid: PDLIM3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PDLIM3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008092cytoskeletal protein binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0008307structural constituent of muscle IEA--
    GO:0042805actinin binding ----


    PDLIM3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PDLIM3:
     Decreased Wnt reporter activit  Decreased influenza A virus in 

    Animal Models:
         Mouse knock-out Pdlim3tm1Dsb for PDLIM3
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pdlim3):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle  normal 

    PDLIM3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDLIM3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDLIM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for PDLIM3 (Q53GG51, 3 ENSP000002847704) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCA1O954773, ENSP000003638684I2D: score=1 STRING: ENSP00000363868
    ACTN1P128143, ENSP000003779414I2D: score=1 STRING: ENSP00000377941
    RANBP2P497921EBI-5658852,EBI-973138
    ZNF408ENSP000003096064STRING: ENSP00000309606
    STK35ENSP000002460324STRING: ENSP00000246032
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization IEA--
    GO:0007507heart development IEA--


    PDLIM3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDLIM3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDLIM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDLIM3
    2 Novoseek chemical compound relationships for PDLIM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 7.74 4 9268344 (1), 16419137 (1), 17764474 (1), 7798324 (1)
    calcium 0 6 16717394 (2), 15160545 (1), 9407400 (1), 11350446 (1)

    Search CenterWatch for drugs/clinical trials and news about PDLIM3 / PDLI3 

    Transcripts
    for PDLIM3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDLIM3 gene (4 alternative transcripts): 
    NM_001114107.4  NM_001257962.1  NM_001257963.1  NM_014476.5  

    Unigene Cluster for PDLIM3:

    PDZ and LIM domain 3
    Hs.701364  [show with all ESTs]
    Unigene Representative Sequence: BX647263
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284770(uc003ixw.4) ENST00000514142 ENST00000284771(uc003ixx.4 uc010isi.3)
    ENST00000514308 ENST00000505886 ENST00000512293 ENST00000504011(uc003ixy.3)
    ENST00000504355 ENST00000512380 ENST00000515261 ENST00000284767(uc003ixz.2)


    miRNA
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    hsa-miR-4311 hsa-miR-634 hsa-miR-137 hsa-miR-186* hsa-miR-409-3p hsa-miR-629* hsa-miR-518a-5p hsa-miR-4323
    SwitchGear 3'UTR luciferase reporter plasmid: PDLIM3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDLIM3 (see all 6)
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    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDLIM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDLIM3

    Additional cDNA sequence: 

    AF002280.1 AF002282.1 AF039018.1 AK129607.1 AK129863.1 AK222966.1 AK313253.1 BC027870.1 
    BT007341.1 BX647263.1 NR_047562.1 

    17 DOTS entries:

    DT.100814655  DT.418583  DT.100658560  DT.455256  DT.100679878  DT.40237861  DT.101957087  DT.207588 
    DT.97813711  DT.100641007  DT.121255877  DT.40231908  DT.99966416  DT.121255898  DT.121255908  DT.92434177 
    DT.121255866 

    24/291 AceView cDNA sequences (see all 291):

    F36732 CA449875 F16327 BQ022468 AI373942 AA152089 BI226158 AA595134 
    BE408923 CR605535 CD677482 AI339673 AI368681 AA886444 C03422 BF445806 
    AI147605 BE045954 AA666350 AI096674 AW068999 AI201475 AA487540 AI139454 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                      -     -                 -     -           -                     
    SP2:                                      -           -     -     -     -     -     -                     
    SP3:                                      -                                                               
    SP4:                    -     -           -     -                 -     -                                 
    SP5:                                      -     -                                                         


    ECgene alternative splicing isoforms for PDLIM3

    Expression
    for PDLIM3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDLIM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAGGGAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PDLIM3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    AdiposeInterscapular Brown Adipose DepotAdipose
    BoneZeugopod Epiphyseal EndBone
    HeartRight VentricleHeart
    TestisSeminiferous TubulesTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Epiblast-like cells (Reconstitution of mo...)
    Primordial germ cell-like cells (Reconstitution of mo...)

    See PDLIM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDLIM3

    SOURCE GeneReport for Unigene cluster: Hs.701364

    UniProtKB/Swiss-Prot: PDLI3_HUMAN, Q53GG5
    Tissue specificity: Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific

        SABiosciences Custom PCR Arrays for PDLIM3
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    In Situ
    Assay Products:     
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    Orthologs
    for PDLIM3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PDLIM3 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PDLIM36
    		 PDZ and LIM domain 3
    		 80(a)
    		 1 ↔ 1
    		 4(62896943-62917937)
    lizard
    (Anolis carolinensis)    		 Reptilia PDLIM36
    		 --
    		 79(a)
    		 1 ↔ 1
    		 5(112754264-112795980)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.138942 Xenopus laevis transcribed sequence with moderate similarity more 78.46(n)    BJ063969.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pdlim3b6
    pdlim3a6
    		 PDZ and LIM domain 3a
    		 60(a)
    51(a)
    		 1 ↔ many
    1 ↔ many
    		 14(30652299-30669733)
    1(16463748-16477756)
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 23(a)
    19(a)
    		 many ↔ many
    many ↔ many
    		 Group16.4(117929-160922)
    GroupUn.6806(1178-2814)


    ENSEMBL Gene Tree for PDLIM3 (if available)
    TreeFam Gene Tree for PDLIM3 (if available) 

    Paralogs
    for PDLIM3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDLIM3 gene
    PDLIM42  PDLIM12  PDLIM22  
    7 SIMAP similar genes for PDLIM3 using alignment to 2 protein entries:     PDLI3_HUMAN (see all proteins):
    PDLIM5    PDLIM7    LDB3    PDLIM2    PDLIM1    LHx4
    PDLIM4

    PDLIM3 for paralogs           About GeneDecksing



    Genomic Variants
    for PDLIM3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1564 NCBI SNPs in PDLIM3 are shown (see all 1564)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs623473601,2
    		C,F,untested186427735(+) GCTGTG/ATGGGC 9 /T /I mis13Minor allele frequency- A:0.01NA EU 5791
    rs119443251,2
    		C,F,H,untested186435443(+) GATCAC/TGAAAG 8 M V int1 mis113Minor allele frequency- T:0.03NA NS EA CSA WA EU 6422
    rs1417846221,2
    		--186421318(+) ATAGGA/GTTCAT 5 -- ds50010--------
    rs1437636161,2
    		--186421356(+) TGATCC/TGACAG 5 -- ds50010--------
    rs1846231961,2
    		--186421438(+) CCCGCC/TGCTCA 5 -- ds50010--------
    rs1899416551,2
    		--186421439(+) CCGCCA/GCTCAC 5 -- ds50010--------
    rs1144974511,2
    		F,--186421485(+) GACTGG/CTATCA 5 -- ds50011Minor allele frequency- C:0.07WA 118
    rs727159071,2
    		C,--186421503(+) GTGGGA/GGCTGG 5 -- ds50010--------
    rs1813692161,2
    		--186421552(+) TTCTAC/TTCAGC 5 -- ds50010--------
    rs1419762461,2
    		--186421608(+) AGGTGC/TTGCCC 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for PDLIM3 (186421814 - 186456766 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for PDLIM3
         10 CNVs: 62304 51349 98994 44148 3530 43469 31209 92618 36240 64058
         1 Indel: 80626
    Human Gene Mutation Database (HGMD): PDLIM3

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    Disorders / Diseases
    for PDLIM3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDLIM3 for disorders           About GeneDecksing

    OMIM gene information: 605889    OMIM disorders: --

    20/29 diseases for PDLIM3 (see all 29):    About MalaCards
    myotonic dystrophy    osteitis fibrosa    limb-girdle muscular dystrophy    infantile onset spinocerebellar ataxia
    muscular dystrophy    facioscapulohumeral muscular dystrophy    atrial fibrillation    primary biliary cirrhosis
    b-cell lymphomas    frontotemporal dementia    paget's disease of bone    secondary hyperparathyroidism
    malignant histiocytosis    enuresis    histiocytosis    spinocerebellar ataxia
    hypertrophic cardiomyopathy    hyperparathyroidism    osteosclerosis    primary hyperparathyroidism

    1 disease from the University of Copenhagen DISEASES database for PDLIM3:
    Infantile onset spinocerebellar ataxia

    7 Novoseek disease relationships for PDLIM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular dystrophy facioscapulohumeral 73.7 2 10063829 (1)
    osteitis fibrosa 68 1 1474716 (1)
    paroxysmal atrial fibrillation 41.2 1 7699880 (1)
    myopathy 40.1 3 10821877 (2), 18260132 (1)
    bone diseases 36.3 1 10821877 (1)
    cardiomyopathy 9.83 2 11329061 (1)
    tumors 0 1 20042479 (1)

    Human Genome Epidemiology (HuGE) Navigator: PDLIM3 (1 document)

    Export disorders for PDLIM3 gene to outside databases

    Publications
    for PDLIM3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDLIM3 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with PDLIM3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Exclusion of muscle specific actinin-associated LIM protein (ALP) gene from 4q35 facioscapulohumeral muscular dystrophy (FSHD) candidate genes. (PubMed id 10063829)1, 2, 3, 9 Bouju S.... Dechesne C.A. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. (PubMed id 9334352)1, 2 Xia H.... Bredt D.S. (1997)
    4. Novel gene transcripts preferentially expressed in hu man muscles revealed by quantitative hybridization of a high density cDNA array . (PubMed id 8828038)1, 3 PiActu G....Auffray C. (1996)
    5. The ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line. (PubMed id 15084604)1, 9 Klaavuniemi T....Ylanne J. (2004)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Alternative splicing of PDLIM3/ALP, for I+-actinin-ass ociated LIM protein 3, is aberrant in persons with myotonic dystrophy. (PubMed id 21549096)1 Ohsawa N....Ishiura S. (2011)
    8. Analysis of the Z-disc genes PDLIM3 and MYPN in patie nts with hypertrophic cardiomyopathy. (PubMed id 20801532)1 Bagnall R.D....Semsarian C. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. (PubMed id 19412328)1 Hershberger R.E....Litt M. (2008)

    External Searches for PDLIM3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing PDLIM3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27295 HGNC: 20767 AceView: PDLIM3 Ensembl:ENSG00000154553 euGenes: HUgn27295
    ECgene: PDLIM3 H-InvDB: PDLIM3

    Other Databases showing PDLIM3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDLIM3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDLIM3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PDLIM3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDLIM3 gene:
    Search GeneIP for patents involving PDLIM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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