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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDLIM2 Gene

protein-coding GIFtS: 53
GCID: GC08P022435

PDZ and LIM domain 2 (mystique)

Explore 5 diseases affiliated with
PDLIM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PDZ And LIM Domain 2 (Mystique)¹ ²
MYSTIQUE² ⁵
SLIM²
PDZ And LIM Domain Protein 2²
PDZ-LIM Protein Mystique³

External Ids:	HGNC: 13992¹	Entrez Gene: 64236²	Ensembl: ENSG00000120913⁷	OMIM: 609722⁵	UniProtKB: Q96JY6³

Export aliases for PDLIM2 gene to outside databases

Previous GC identifers: GC00U990854 GC08P022788 GC08P022256 GC08P022458 GC08P022492 GC08P020978

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDLIM2:

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses

anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton

via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this

gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced

transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6

Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the

migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and

suppresses anchorage independent growth. May contribute to tumor cell migratory capacity

Gene Wiki entry for PDLIM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDLIM2 gene promoter:
USF-1 SEF-1 (1) HNF-4alpha2 Zic3 HNF-4alpha1 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDLIM2 promoter sequence

Search SABiosciences Chromatin IP Primers for PDLIM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDLIM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.3

PDLIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDLIM2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P022435: view genomic region (about GC identifiers)

Start:	22,435,792 bp from pter	End:	22,455,538 bp from pter
Size:	19,747 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6 (See protein sequence)

Recommended Name: PDZ and LIM domain protein 2

Size: 352 amino acids; 37459 Da

Subunit: Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9 (By similarity)

Subcellular location: Cytoplasm. Nucleus. Note=May be partially nuclear

Subcellular location: Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and

alpha-actinin but not with paxillin (PXN)

Subcellular location: Isoform 2: Cytoplasm, cytoskeleton

Subcellular location: Isoform 3: Nucleus

Sequence caution: Sequence=AAG16633.1; Type=Frameshift; Positions=131; Sequence=AAL55747.1; Type=Frameshift;

Positions=42, 207; Sequence=AAL65265.1; Type=Frameshift; Positions=237; Sequence=BAB15788.1; Type=Erroneous

initiation;

2 PDB 3D structures from and Proteopedia for PDLIM2:

2PA1 (3D)

3PDV (3D)

Secondary accessions: D3DSR5 Q7Z584 Q86WM8 Q8WZ29 Q9H4L9 Q9H7I2

Alternative splicing: 4 isoforms: Q96JY6-1 Q96JY6-2 Q96JY6-3 Q96JY6-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDLIM2: NX_Q96JY6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96JY6

PDLIM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_067643.3 NP_789847.1 NP_932159.1

ENSEMBL proteins:

ENSP00000401992 ENSP00000312634 ENSP00000394376 ENSP00000380868 ENSP00000414427

ENSP00000397738 ENSP00000392920 ENSP00000407643 ENSP00000386868 ENSP00000265810

ENSP00000387084 ENSP00000412936 ENSP00000380867 ENSP00000342035

Human Recombinant Protein Products:

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	Novus Biologicals PDLIM2 Protein Novus Biologicals PDLIM2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PDLIM2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005925	focal adhesion	IDA	--
GO:0009986	cell surface	IDA	12493773

PDLIM2 for ontologies About GeneDecksing

PDLIM2 Antibody Products:

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	Search ThermoFisher Antibodies for PDLIM2

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	Uscn ELISAs and CLIAs for PDLIM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDLIM2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001478 PDZ

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry Q96JY6

ProtoNet protein and cluster: Q96JY6

2 Blocks protein families:

IPB001478 PDZ/DHR/GLGF domain

IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6

Similarity: Contains 1 LIM zinc-binding domain

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6

Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the

migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and

suppresses anchorage independent growth. May contribute to tumor cell migratory capacity

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PDLIM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDLIM2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate PDLIM2 (see all 15):
		hsa-miR-4271 hsa-miR-550a hsa-miR-3065-3p hsa-miR-566 hsa-miR-128 hsa-miR-3681* hsa-miR-764 hsa-miR-214

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDLIM2 (see all 7) OriGene shRNA RFP: PDLIM2 OriGene siRNA: PDLIM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDLIM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PDLIM2

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		Search LifeMap BioReagents cell lines for PDLIM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0032036	myosin heavy chain binding	--	--
GO:0051371	muscle alpha-actinin binding	--	--

PDLIM2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PDLIM2:

Upregulation of NF-kappaB path

Animal Models:
Mouse knock-out Pdlim2^tm1Gru for PDLIM2
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pdlim2):

immune system

PDLIM2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response IL-12 signaling pathway

Immune response IL-12 signaling pathway

1.00

Immune response_IL-12 signaling pathway

0.96

Protein Stability

Protein Stability

1.00

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

NF-kappaB Signaling

NF-kappaB Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PDLIM2

Immune response IL-12 signaling pathway

3 Cell Signaling Technology (CST) Pathways for PDLIM2

	Cytoskeletal Signaling
	NF-kappaB Signaling
	Protein Stability

1 GeneGo (Thomson Reuters) Pathway for PDLIM2

Immune response IL-12 signaling pathway

PDLIM2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PDLIM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/8 Interacting proteins for PDLIM2 (Q96JY6³ ENSP00000265810⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELA	Q04206³, ENSP00000384273⁴	I2D: score=1 STRING: ENSP00000384273
PRKCA	P17252³	I2D: score=1
STAT4	Q14765³	I2D: score=1
ACD	ENSP00000377496⁴	STRING: ENSP00000377496
POT1	ENSP00000350249⁴	STRING: ENSP00000350249

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PDLIM2
Search CenterWatch for drugs/clinical trials and news about PDLIM2 / PDLI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDLIM2 gene (3 alternative transcripts):

NM_021630.5 NM_176871.3 NM_198042.3

Unigene Cluster for PDLIM2:

PDZ and LIM domain 2 (mystique)

Hs.632034 [show with all ESTs]

Unigene Representative Sequence: NM_176871

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000456545 ENST00000308354(uc003xbx.2 uc003xby.3) ENST00000452226

ENST00000397761 ENST00000422517 ENST00000436754 ENST00000426493 ENST00000429812

ENST00000409141(uc003xca.3) ENST00000265810(uc003xcc.2) ENST00000409417

ENST00000416159 ENST00000448520 ENST00000491330 ENST00000464275 ENST00000443561

ENST00000397760 ENST00000339162

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PDLIM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDLIM2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate PDLIM2 (see all 15):
		hsa-miR-4271 hsa-miR-550a hsa-miR-3065-3p hsa-miR-566 hsa-miR-128 hsa-miR-3681* hsa-miR-764 hsa-miR-214

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDLIM2 (see all 7) OriGene shRNA RFP: PDLIM2 OriGene siRNA: PDLIM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDLIM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDLIM2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDLIM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PDLIM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDLIM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDLIM2

Additional cDNA sequence:

AF289563.1 AK024498.1 AK027800.1 AK056748.1 AK092968.1 AY007729.1 AY070438.1 AY217349.1

BC021556.1 BC071774.1

19 DOTS entries:

DT.113766 DT.113764 DT.101982314 DT.100765261 DT.440907 DT.121471462 DT.100806614 DT.121471353

DT.97854069 DT.95298607 DT.100761216 DT.100806616 DT.121471465 DT.92052664 DT.95298605 DT.426387

DT.92058950 DT.92420120 DT.95127662

24/408 AceView cDNA sequences (see all 408):

BX116327 BQ958685 BQ427628 BQ003845 AY217349 BM982439 BC021556 NM_021174

AI674694 BP379120 AK024498 BU179002 AW272585 CR608632 AI685404 NM_199205

AI927868 AI624824 AI767554 CR608004 CF552933 BC018269 AI816526 CN484604

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM2 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	·	13c	^	14	^	15a	·	15b	·	15c	·	15d	·	15e	^	16
SP1:									-		-		-		-				-														-
SP2:																			-														-										-		-		-		-
SP3:							-		-		-		-		-				-														-
SP4:					-		-		-		-		-		-
SP5:					-		-		-		-		-		-				-														-

ECgene alternative splicing isoforms for PDLIM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDLIM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTAAGTTT

About this image

PDLIM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PDLIM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDLIM2

SOURCE GeneReport for Unigene cluster: Hs.632034

SABiosciences Custom PCR Arrays for PDLIM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDLIM2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDLIM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PDLIM2 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	PDLIM2⁶	--	54(a)	1 ↔ 1	GL343443.1(438252-499241)
zebrafish (Danio rerio)	Actinopterygii	pdlim2¹	PDZ and LIM domain 2 (mystique)	54.66(n) 49.4(a)		560322 NM_001042766.2 NP_001036231.1
honey bee (Apis mellifera)	Insecta	-- --	--	23(a) 23(a)	many ↔ many many ↔ many	GroupUn.6806(1178-2814) Group16.4(117929-160922)

ENSEMBL Gene Tree for PDLIM2 (if available)
TreeFam Gene Tree for PDLIM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PDLIM2 gene

PDLIM4² PDLIM1² PDLIM3²

8 SIMAP similar genes for PDLIM2 using alignment to 10 protein entries: PDLI2_HUMAN (see all proteins):

PDLIM5 FLJ00349 LDB3 SYNPO2 PDLIM7 PDLIM3

PDLIM1 PDLIM4

PDLIM2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PDLIM2
PGOHUM00000240884

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190341507^1,2		--	22434523(+)	`GGGCAC/GGTCCA`	1	--	us2k¹		0	--	--	--	--
rs181014385^1,2		--	22434535(+)	`CCCATC/TCTGGC`	1	--	us2k¹		0	--	--	--	--
rs184293344^1,2		--	22434599(+)	`CAGCTA/CTTTTT`	1	--	us2k¹		0	--	--	--	--
rs188025119^1,2		--	22434624(+)	`ATTCCC/TTCATA`	1	--	us2k¹		0	--	--	--	--
rs138537264^1,2		--	22434644(+)	`AGGGCC/TGAGGC`	1	--	us2k¹		0	--	--	--	--
rs7817943^1,2	C,	--	22434712(+)	`CTTCCC/TGCAGC`	1	--	us2k¹		0	--	--	--	--
rs35034767^1,2	C,F,	--	22434727(+)	`AAACCC/GTCCAA`	1	--	us2k¹		10		NA WA CSA EA	372
rs77483772^1,2	C,F,	--	22434752(+)	`CACCAC/TGGTCC`	1	--	us2k¹		1		NA	120
rs181273876^1,2		--	22434804(+)	`GGAGGC/TGAAGG`	1	--	us2k¹		0	--	--	--	--
rs185280703^1,2		--	22434834(+)	`AGATGG/TCTCAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PDLIM2 (22435792 - 22455538 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PDLIM2
2 CNVs: 2746 3726

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDLIM2

DNA2.0 Custom Variant and Variant Library Synthesis for PDLIM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PDLIM2 for disorders           About GeneDecksing

OMIM gene information: 609722    OMIM disorders: --

5 diseases for PDLIM2:    About MalaCards

breast cancer t-cell leukemia leukemia adult t-cell leukemia

colon cancer

Export disorders for PDLIM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PDLIM2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with PDLIM2)

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Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth. (PubMed id 15659642)^{1, 2, 9} Loughran G....O'connor R. (2005)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)^{1, 2} Hattori A.... Ohara O. (2000)
Epigenetic repression of PDZ-LIM domain-containing pr otein 2: implications for the biology and treatment of breast cancer. (PubMed id 20185823)^{1, 9} Qu Z....Xiao G. (2010)
Human T-cell leukemia virus type I-mediated repressio n of PDZ-LIM domain-containing protein 2 involves DNA methylation but independe nt of the viral oncoprotein tax. (PubMed id 19794962)^{1, 9} Yan P....Xiao G. (2009)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Pdlim2 is a novel actin-regulating protein of podocyte foot processes. (PubMed id 21814175)¹ Sistani L....Patrakka J. (2011)
Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)¹ Lee O.H....Songyang Z. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64236	HGNC: 13992	AceView: DBC-1andPDLIM2	Ensembl:ENSG00000120913	euGenes: HUgn64236
ECgene: PDLIM2	H-InvDB: PDLIM2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PDLIM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PDLIM2 gene
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Patent Information for PDLIM2 gene:
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