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Aliases for PDLIM2 Gene

Aliases for PDLIM2 Gene

  • PDZ And LIM Domain 2 2 3
  • PDZ And LIM Domain 2 (Mystique) 3 5
  • PDZ-LIM Protein Mystique 4
  • Mystique 2
  • MYSTIQUE 3
  • SLIM 3

External Ids for PDLIM2 Gene

Previous GeneCards Identifiers for PDLIM2 Gene

  • GC00U990854
  • GC08P022788
  • GC08P022256
  • GC08P022458
  • GC08P022492
  • GC08P022435
  • GC08P020978

Summaries for PDLIM2 Gene

Entrez Gene Summary for PDLIM2 Gene

  • This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PDLIM2 Gene

PDLIM2 (PDZ And LIM Domain 2) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and Immune response_IL-12 signaling pathway. GO annotations related to this gene include alpha-actinin binding and filamin binding. An important paralog of this gene is PDLIM4.

UniProtKB/Swiss-Prot for PDLIM2 Gene

  • Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

Gene Wiki entry for PDLIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDLIM2 Gene

Genomics for PDLIM2 Gene

Regulatory Elements for PDLIM2 Gene

Enhancers for PDLIM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDLIM2 on UCSC Golden Path with GeneCards custom track

Promoters for PDLIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDLIM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDLIM2 Gene

Chromosome:
8
Start:
22,578,279 bp from pter
End:
22,598,025 bp from pter
Size:
19,747 bases
Orientation:
Plus strand

Genomic View for PDLIM2 Gene

Genes around PDLIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDLIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDLIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDLIM2 Gene

Proteins for PDLIM2 Gene

  • Protein details for PDLIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JY6-PDLI2_HUMAN
    Recommended name:
    PDZ and LIM domain protein 2
    Protein Accession:
    Q96JY6
    Secondary Accessions:
    • D3DSR5
    • J3KNH4
    • Q7Z584
    • Q86WM8
    • Q8WZ29
    • Q9H4L9
    • Q9H7I2

    Protein attributes for PDLIM2 Gene

    Size:
    352 amino acids
    Molecular mass:
    37459 Da
    Quaternary structure:
    • Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.
    SequenceCaution:
    • Sequence=AAG16633.1; Type=Frameshift; Positions=131; Evidence={ECO:0000305}; Sequence=AAL55747.1; Type=Frameshift; Positions=42, 207; Evidence={ECO:0000305}; Sequence=AAL65265.1; Type=Frameshift; Positions=237; Evidence={ECO:0000305}; Sequence=BAB15788.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDLIM2 Gene

    Alternative splice isoforms for PDLIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDLIM2 Gene

Proteomics data for PDLIM2 Gene at MOPED

Post-translational modifications for PDLIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PDLIM2 Gene

Domains & Families for PDLIM2 Gene

Gene Families for PDLIM2 Gene

Protein Domains for PDLIM2 Gene

Suggested Antigen Peptide Sequences for PDLIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JY6

UniProtKB/Swiss-Prot:

PDLI2_HUMAN :
  • Contains 1 LIM zinc-binding domain.
Domain:
  • Contains 1 LIM zinc-binding domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with PDLIM2: view

Function for PDLIM2 Gene

Molecular function for PDLIM2 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

Gene Ontology (GO) - Molecular Function for PDLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031005 filamin binding IEA --
GO:0051393 alpha-actinin binding IEA --
genes like me logo Genes that share ontologies with PDLIM2: view
genes like me logo Genes that share phenotypes with PDLIM2: view

Animal Models for PDLIM2 Gene

MGI Knock Outs for PDLIM2:

Animal Model Products

miRNA for PDLIM2 Gene

miRTarBase miRNAs that target PDLIM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDLIM2 Gene

Localization for PDLIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDLIM2 Gene

Cytoplasm. Nucleus. Note=May be partially nuclear.
Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
Isoform 2: Cytoplasm, cytoskeleton.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDLIM2 Gene COMPARTMENTS Subcellular localization image for PDLIM2 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PDLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030864 cortical actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with PDLIM2: view

Pathways & Interactions for PDLIM2 Gene

genes like me logo Genes that share pathways with PDLIM2: view

Pathways by source for PDLIM2 Gene

2 Cell Signaling Technology pathways for PDLIM2 Gene
1 GeneGo (Thomson Reuters) pathway for PDLIM2 Gene

Gene Ontology (GO) - Biological Process for PDLIM2 Gene

None

No data available for SIGNOR curated interactions for PDLIM2 Gene

Drugs & Compounds for PDLIM2 Gene

No Compound Related Data Available

Transcripts for PDLIM2 Gene

Unigene Clusters for PDLIM2 Gene

PDZ and LIM domain 2 (mystique):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - - -
SP10: - -
SP11: - - - - - - - -
SP12:

Relevant External Links for PDLIM2 Gene

GeneLoc Exon Structure for
PDLIM2
ECgene alternative splicing isoforms for
PDLIM2

Expression for PDLIM2 Gene

mRNA expression in normal human tissues for PDLIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDLIM2 Gene

This gene is overexpressed in Spleen (x8.3) and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for PDLIM2 Gene

This gene is overexpressed in Bone marrow stromal cell (34.2) and Peripheral blood mononuclear cells (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDLIM2 Gene



SOURCE GeneReport for Unigene cluster for PDLIM2 Gene Hs.632034

genes like me logo Genes that share expression patterns with PDLIM2: view

Protein tissue co-expression partners for PDLIM2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PDLIM2 Gene

Orthologs for PDLIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDLIM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDLIM2 35
  • 82.75 (n)
  • 82.46 (a)
PDLIM2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdlim2 35
  • 79.15 (n)
  • 79.54 (a)
Pdlim2 16
Pdlim2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDLIM2 35
  • 99.45 (n)
  • 99.34 (a)
PDLIM2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdlim2 35
  • 78.48 (n)
  • 78.1 (a)
dog
(Canis familiaris)
Mammalia PDLIM2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDLIM2 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDLIM2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDLIM2 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pdlim2 35
  • 50.74 (n)
  • 44.81 (a)
pdlim2 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3932 36
  • 24 (a)
OneToOne
Species with no ortholog for PDLIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDLIM2 Gene

ENSEMBL:
Gene Tree for PDLIM2 (if available)
TreeFam:
Gene Tree for PDLIM2 (if available)

Paralogs for PDLIM2 Gene

Paralogs for PDLIM2 Gene

Pseudogenes.org Pseudogenes for PDLIM2 Gene

genes like me logo Genes that share paralogs with PDLIM2: view

Variants for PDLIM2 Gene

Sequence variations from dbSNP and Humsavar for PDLIM2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2086600 -- 22,586,599(-) AAATC(A/C)CCCAG intron-variant
rs2294047 -- 22,585,148(-) ATGGC(C/T)GCCTC reference, synonymous-codon
rs2294048 -- 22,585,063(-) AGTAG(C/G/T)AGGAC reference, missense
rs2294049 -- 22,585,062(-) GTAGG(A/T)GGACC reference, missense
rs2469754 -- 22,582,727(-) GCACG(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDLIM2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv890673 CNV Loss 21882294
dgv7762n71 CNV Loss 21882294
esv2736748 CNV Deletion 23290073

Variation tolerance for PDLIM2 Gene

Gene Damage Index Score: 5.83; 73.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PDLIM2 Gene

Disorders for PDLIM2 Gene

Relevant External Links for PDLIM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDLIM2

No disorders were found for PDLIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDLIM2 Gene

Publications for PDLIM2 Gene

  1. Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth. (PMID: 15659642) Loughran G. … O'connor R. (Mol. Biol. Cell 2005) 3 4 23 67
  2. Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. (PMID: 20185823) Qu Z. … Xiao G. (J. Biol. Chem. 2010) 3 23
  3. Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. (PMID: 19794962) Yan P. … Xiao G. (Neoplasia 2009) 3 23
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  5. Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor I_B (NF-I_B) and STAT3 transcription factors for tumorigenesis and tumor maintenance. (PMID: 25681443) Sun F. … Qu Z. (J. Biol. Chem. 2015) 3

Products for PDLIM2 Gene

Sources for PDLIM2 Gene

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