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PDLIM2 Gene

protein-coding   GIFtS: 55
GCID: GC08P022435

PDZ And LIM Domain 2 (Mystique)

  See PDLIM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PDZ And LIM Domain 2 (Mystique)1 2
MYSTIQUE2 5
SLIM2
PDZ And LIM Domain Protein 22
PDZ-LIM Protein Mystique3

External Ids:    HGNC: 139921   Entrez Gene: 642362   Ensembl: ENSG000001209137   OMIM: 6097225   UniProtKB: Q96JY63   

Export aliases for PDLIM2 gene to outside databases

Previous GC identifers: GC00U990854 GC08P022788 GC08P022256 GC08P022458 GC08P022492 GC08P020978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDLIM2 Gene:
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses
anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin
cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased
expression of this gene is associated with several malignancies including breast cancer and adult T-cell
leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for PDLIM2 Gene:
PDLIM2 (PDZ and LIM domain 2 (mystique)) is a protein-coding gene. Diseases associated with PDLIM2 include adult t-cell leukemia, and t-cell leukemia. GO annotations related to this gene include myosin heavy chain binding and muscle alpha-actinin binding. An important paralog of this gene is PDLIM4.

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6
Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for
the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and
suppresses anchorage independent growth. May contribute to tumor cell migratory capacity

Gene Wiki entry for PDLIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDLIM2 gene promoter:
         USF-1   SEF-1 (1)   HNF-4alpha2   Zic3   HNF-4alpha1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDLIM2 promoter sequence
   Search Chromatin IP Primers for PDLIM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDLIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

PDLIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDLIM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022435:  view genomic region     (about GC identifiers)

Start:
22,435,792 bp from pter      End:
22,455,538 bp from pter
Size:
19,747 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6 (See protein sequence)
Recommended Name: PDZ and LIM domain protein 2  
Size: 352 amino acids; 37459 Da
Subunit: Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9 (By similarity)
Sequence caution: Sequence=AAG16633.1; Type=Frameshift; Positions=131; Sequence=AAL55747.1; Type=Frameshift;
Positions=42, 207; Sequence=AAL65265.1; Type=Frameshift; Positions=237; Sequence=BAB15788.1; Type=Erroneous
initiation;
2 PDB 3D structures from and Proteopedia for PDLIM2:
2PA1 (3D)        3PDV (3D)    
Secondary accessions: D3DSR5 J3KNH4 Q7Z584 Q86WM8 Q8WZ29 Q9H4L9 Q9H7I2
Alternative splicing: 5 isoforms:  Q96JY6-1   Q96JY6-2   Q96JY6-3   Q96JY6-4   Q96JY6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDLIM2: NX_Q96JY6

Explore proteomics data for PDLIM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PDLIM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_067643.3  NP_789847.1  NP_932159.1  

    ENSEMBL proteins: 
     ENSP00000401992   ENSP00000312634   ENSP00000394376   ENSP00000380868   ENSP00000397738  
     ENSP00000392920   ENSP00000407643   ENSP00000386868   ENSP00000265810   ENSP00000387084  
     ENSP00000412936   ENSP00000380867   ENSP00000342035  

    PDLIM2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PDLIM2

     
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    Search eBioscience for ELISAs for PDLIM2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001478 PDZ
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q96JY6

    ProtoNet protein and cluster: Q96JY6

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6
    Similarity: Contains 1 LIM zinc-binding domain
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with PDLIM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDLI2_HUMAN, Q96JY6
    Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for
    the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and
    suppresses anchorage independent growth. May contribute to tumor cell migratory capacity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0031005filamin binding IEA--
    GO:0032036myosin heavy chain binding IEA--
    GO:0051371muscle alpha-actinin binding IEA--
         
    Find genes that share ontologies with PDLIM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDLIM2:
     Upregulation of NF-kappaB path 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pdlim2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with PDLIM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pdlim2tm1Gru for PDLIM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDLIM2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDLIM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDLIM2

    miRNA
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    miRTarBase miRNAs that target PDLIM2:
    hsa-mir-484 (MIRT041815)

    Block miRNA regulation of human, mouse, rat PDLIM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDLIM2 (see all 15):
    hsa-miR-4271 hsa-miR-550a hsa-miR-3065-3p hsa-miR-566 hsa-miR-128 hsa-miR-3681* hsa-miR-764 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDLIM2

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    GenScript: all cDNA clones in your preferred vector (see all 3): PDLIM2 (NM_021630)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDLIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDLIM2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDLI2_HUMAN, Q96JY6: Cytoplasm. Nucleus. Note=May be partially nuclear
    PDLI2_HUMAN, Q96JY6: Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and
    alpha-actinin but not with paxillin (PXN)
    PDLI2_HUMAN, Q96JY6: Isoform 2: Cytoplasm, cytoskeleton
    PDLI2_HUMAN, Q96JY6: Isoform 3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005925focal adhesion IDA--
    GO:0015629actin cytoskeleton IDA--

    Find genes that share ontologies with PDLIM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDLIM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability
    2NF-kappaB Signaling
    NF-kappaB Signaling
    3Immune response IL 12 signaling pathway
    Immune response IL 12 signaling pathway
    4Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with PDLIM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for PDLIM2
        Cytoskeletal Signaling
    NF-kappaB Signaling
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for PDLIM2
        Immune response IL-12 signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDLIM2
    Interactions:

        Search GeneGlobe Interaction Network for PDLIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for PDLIM2 (Q96JY63 ENSP000002658104) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    STAT4Q147653I2D: score=1 
    STAT1ENSP000003543944STRING: ENSP00000354394
    ACDENSP000003774964STRING: ENSP00000377496
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDLIM2 (PDLI2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDLIM2 gene (3 alternative transcripts): 
    NM_021630.5  NM_176871.3  NM_198042.3  

    Unigene Cluster for PDLIM2:

    PDZ and LIM domain 2 (mystique)
    Hs.632034  [show with all ESTs]
    Unigene Representative Sequence: NM_176871
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456545 ENST00000308354(uc003xbx.2 uc003xby.3) ENST00000452226
    ENST00000397761 ENST00000436754 ENST00000426493 ENST00000429812 ENST00000409141(uc003xca.3)
    ENST00000265810(uc003xcc.2) ENST00000409417 ENST00000416159 ENST00000448520
    ENST00000491330 ENST00000464275 ENST00000443561 ENST00000397760 ENST00000339162

    miRNA
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    Block miRNA regulation of human, mouse, rat PDLIM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDLIM2 (see all 15):
    hsa-miR-4271 hsa-miR-550a hsa-miR-3065-3p hsa-miR-566 hsa-miR-128 hsa-miR-3681* hsa-miR-764 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PDLIM2 (NM_021630)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDLIM2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDLIM2
      QuantiTect SYBR Green Assays in human, mouse, rat PDLIM2
      QuantiFast Probe-based Assays in human, mouse, rat PDLIM2

    Additional mRNA sequence: 

    AF289563.1 AK024498.1 AK027800.1 AK056748.1 AK092968.1 AY007729.1 AY070438.1 AY217349.1 
    BC021556.1 BC071774.1 

    22 DOTS entries:

    DT.113766  DT.113764  DT.101982314  DT.100765261  DT.440907  DT.121471462  DT.100806614  DT.121471353 
    DT.97854069  DT.95298607  DT.100761216  DT.100806616  DT.121471465  DT.455021  DT.92052664  DT.95127662 
    DT.95298605  DT.100764893  DT.121471488  DT.426387  DT.92058950  DT.92420120 

    Selected AceView cDNA sequences (see all 408):

    BM982439 AU125328 BQ427628 CR608632 BM830218 BQ675499 AY217349 BM456908 
    AI624824 AA804789 AL834351 CR613641 AI927868 BE742364 CR595864 AA953487 
    AV648739 BM665854 NM_176871 AA883927 BX104153 CF121260 BU682837 BE621043 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16
    SP1:                          -     -     -     -           -                                         -                                                         
    SP2:                                                        -                                         -                             -     -     -     -         
    SP3:                    -     -     -     -     -           -                                         -                                                         
    SP4:              -     -     -     -     -     -                                                                                                               
    SP5:              -     -     -     -     -     -           -                                         -                                                         


    ECgene alternative splicing isoforms for PDLIM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDLIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTAAGTTT
    PDLIM2 Expression
    About this image


    PDLIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Lung (Respiratory System)
     
     Spleen (Hematopoietic System)
    PDLIM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDLIM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632034
        Custom PCR Arrays for PDLIM2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PDLIM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PDLIM2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdlim21 , 5 PDZ and LIM domain 21, 5 79.15(n)1
    79.54(a)1
      14 (36.26 cM)5
    2130191  NM_001253736.11  NP_001240665.11 
     701642185 
    lizard
    (Anolis carolinensis)
    Reptilia PDLIM26
    PDZ and LIM domain 2 (mystique)
    52(a)
    1 ↔ 1
    GL343443.1(421176-501908)
    zebrafish
    (Danio rerio)
    Actinopterygii pdlim21 PDZ and LIM domain 2 (mystique) 50.74(n)
    44.81(a)
      560322  NM_001042766.2  NP_001036231.1 


    ENSEMBL Gene Tree for PDLIM2 (if available)
    TreeFam Gene Tree for PDLIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDLIM2 gene
    PDLIM42  PDLIM12  PDLIM32  
    6 SIMAP similar genes for PDLIM2 using alignment to 8 protein entries:     PDLI2_HUMAN (see all proteins):
    PDLIM5    FLJ00349    PDLIM3    SYNPO2    PDLIM7    PDLIM1

    Find genes that share paralogs with PDLIM2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PDLIM2
    PGOHUM00000240884


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDLIM2 (see all 518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392286651,2
    --20978074(+) TCATCC/TTTATA 2 -- us2k10--------
    rs1150194811,2
    C,F--20978085(+) GCCTGG/CGCTTC 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1903415071,2
    --22434523(+) GGGCAC/GGTCCA 1 -- us2k10--------
    rs1810143851,2
    --22434535(+) CCCATC/TCTGGC 1 -- us2k10--------
    rs1842933441,2
    --22434599(+) CAGCTA/CTTTTT 1 -- us2k10--------
    rs1880251191,2
    --22434624(+) ATTCCC/TTCATA 1 -- us2k10--------
    rs1385372641,2
    --22434644(+) AGGGCC/TGAGGC 1 -- us2k10--------
    rs78179431,2
    C--22434712(+) CTTCCC/TGCAGC 1 -- us2k10--------
    rs350347671,2
    C,F--22434727(+) AAACCC/GTCCAA 1 -- us2k110Minor allele frequency- G:0.13NA WA CSA EA 372
    rs774837721,2
    C,F--22434752(+) CACCAC/TGGTCC 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for PDLIM2 (22435792 - 22455538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PDLIM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736748CNV Deletion23290073
    dgv7762n71CNV Loss21882294
    nsv890673CNV Loss21882294
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDLIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for PDLIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609722    OMIM disorders: --

    3 diseases for PDLIM2:    
    About MalaCards
    adult t-cell leukemia    t-cell leukemia    breast cancer


    Find genes that share disorders with PDLIM2           About GenesLikeMe


    Export disorders for PDLIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDLIM2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PDLIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth. (PubMed id 15659642)1, 2, 9 Loughran G....O'connor R. (Mol. Biol. Cell 2005)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    6. Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. (PubMed id 20185823)1, 9 Qu Z....Xiao G. (J. Biol. Chem. 2010)
    7. Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. (PubMed id 19794962)1, 9 Yan P....Xiao G. (Neoplasia 2009)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Pdlim2 is a novel actin-regulating protein of podocyte foot processes. (PubMed id 21814175)1 Sistani L....Patrakka J. (Kidney Int. 2011)
    10. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64236 HGNC: 13992 AceView: DBC-1andPDLIM2 Ensembl:ENSG00000120913 euGenes: HUgn64236
    ECgene: PDLIM2 H-InvDB: PDLIM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDLIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDLIM2 gene:
    Search GeneIP for patents involving PDLIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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