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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDLIM2 Gene

protein-coding   GIFtS: 54
GCID: GC08P022435

PDZ And LIM Domain 2 (Mystique)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
PDZ And LIM Domain 2 (Mystique)1 2
MYSTIQUE2 5
SLIM2
PDZ And LIM Domain Protein 22
PDZ-LIM Protein Mystique3

External Ids:    HGNC: 139921   Entrez Gene: 642362   Ensembl: ENSG000001209137   OMIM: 6097225   UniProtKB: Q96JY63   

Export aliases for PDLIM2 gene to outside databases

Previous GC identifers: GC00U990854 GC08P022788 GC08P022256 GC08P022458 GC08P022492 GC08P020978


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDLIM2 Gene:
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses
anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin
cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased
expression of this gene is associated with several malignancies including breast cancer and adult T-cell
leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for PDLIM2 Gene: 
PDLIM2 (PDZ and LIM domain 2 (mystique)) is a protein-coding gene. Diseases associated with PDLIM2 include adult t-cell leukemia, and t-cell leukemia, and among its related super-pathways are Immune response IL-12 signaling pathway. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is PDLIM4.

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6
Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for
the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and
suppresses anchorage independent growth. May contribute to tumor cell migratory capacity

Gene Wiki entry for PDLIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDLIM2 gene promoter:
         USF-1   SEF-1 (1)   HNF-4alpha2   Zic3   HNF-4alpha1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDLIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDLIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDLIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

PDLIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDLIM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022435:  view genomic region     (about GC identifiers)

Start:
22,435,792 bp from pter      End:
22,455,538 bp from pter
Size:
19,747 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6 (See protein sequence)
Recommended Name: PDZ and LIM domain protein 2  
Size: 352 amino acids; 37459 Da
Subunit: Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9 (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=May be partially nuclear
Subcellular location: Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and
alpha-actinin but not with paxillin (PXN)
Subcellular location: Isoform 2: Cytoplasm, cytoskeleton
Subcellular location: Isoform 3: Nucleus
Sequence caution: Sequence=AAG16633.1; Type=Frameshift; Positions=131; Sequence=AAL55747.1; Type=Frameshift;
Positions=42, 207; Sequence=AAL65265.1; Type=Frameshift; Positions=237; Sequence=BAB15788.1; Type=Erroneous
initiation;
2 PDB 3D structures from and Proteopedia for PDLIM2:
2PA1 (3D)        3PDV (3D)    
Secondary accessions: D3DSR5 J3KNH4 Q7Z584 Q86WM8 Q8WZ29 Q9H4L9 Q9H7I2
Alternative splicing: 5 isoforms:  Q96JY6-1   Q96JY6-2   Q96JY6-3   Q96JY6-4   Q96JY6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDLIM2: NX_Q96JY6

Explore proteomics data for PDLIM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JY6

  • PDLIM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDLIM2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_067643.3  NP_789847.1  NP_932159.1  

    ENSEMBL proteins: 
     ENSP00000401992   ENSP00000312634   ENSP00000394376   ENSP00000380868   ENSP00000397738  
     ENSP00000392920   ENSP00000407643   ENSP00000386868   ENSP00000265810   ENSP00000387084  
     ENSP00000412936   ENSP00000380867   ENSP00000342035  

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    Novus Biologicals PDLIM2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDLIM2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005925focal adhesion IDA--
    GO:0009986cell surface IDA12493773
    GO:0015629actin cytoskeleton IDA--

    PDLIM2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001478 PDZ
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q96JY6

    ProtoNet protein and cluster: Q96JY6

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: PDLI2_HUMAN, Q96JY6
    Similarity: Contains 1 LIM zinc-binding domain
    Similarity: Contains 1 PDZ (DHR) domain


    PDLIM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDLI2_HUMAN, Q96JY6
    Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for
    the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and
    suppresses anchorage independent growth. May contribute to tumor cell migratory capacity

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0031005filamin binding IEA--
    GO:0032036myosin heavy chain binding IEA--
    GO:0051371muscle alpha-actinin binding IEA--
         
    PDLIM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDLIM2:
     Upregulation of NF-kappaB path 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pdlim2):
     immune system 

    PDLIM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdlim2tm1Gru for PDLIM2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDLIM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDLIM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDLIM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDLIM2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDLIM2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response IL-12 signaling pathway
    Immune response IL-12 signaling pathway0.96
    2Protein Stability
    Protein Stability
    3Cytoskeletal Signaling
    Cytoskeletal Signaling
    4NF-kappaB Signaling
    NF-kappaB Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PDLIM2
        Immune response IL-12 signaling pathway


    3 Cell Signaling Technology (CST) Pathways for PDLIM2
        Cytoskeletal Signaling
    NF-kappaB Signaling
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for PDLIM2
        Immune response IL-12 signaling pathway



    PDLIM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDLIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for PDLIM2 (Q96JY63 ENSP000002658104) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    PRKCAP172523I2D: score=1 
    STAT4Q147653I2D: score=1 
    ACDENSP000003774964STRING: ENSP00000377496
    POT1ENSP000003502494STRING: ENSP00000350249
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDLIM2 (PDLI2)

    Search CenterWatch for drugs/clinical trials and news about PDLIM2 / PDLI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDLIM2 gene (3 alternative transcripts): 
    NM_021630.5  NM_176871.3  NM_198042.3  

    Unigene Cluster for PDLIM2:

    PDZ and LIM domain 2 (mystique)
    Hs.632034  [show with all ESTs]
    Unigene Representative Sequence: NM_176871
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456545 ENST00000308354(uc003xbx.2 uc003xby.3) ENST00000452226
    ENST00000397761 ENST00000436754 ENST00000426493 ENST00000429812 ENST00000409141(uc003xca.3)
    ENST00000265810(uc003xcc.2) ENST00000409417 ENST00000416159 ENST00000448520
    ENST00000491330 ENST00000464275 ENST00000443561 ENST00000397760 ENST00000339162

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate PDLIM2 (see all 15):
    hsa-miR-4271 hsa-miR-550a hsa-miR-3065-3p hsa-miR-566 hsa-miR-128 hsa-miR-3681* hsa-miR-764 hsa-miR-214
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    Additional mRNA sequence: 

    AF289563.1 AK024498.1 AK027800.1 AK056748.1 AK092968.1 AY007729.1 AY070438.1 AY217349.1 
    BC021556.1 BC071774.1 

    22 DOTS entries:

    DT.113766  DT.113764  DT.101982314  DT.100765261  DT.440907  DT.121471462  DT.100806614  DT.121471353 
    DT.97854069  DT.95298607  DT.100761216  DT.100806616  DT.121471465  DT.455021  DT.92052664  DT.95127662 
    DT.95298605  DT.100764893  DT.121471488  DT.426387  DT.92058950  DT.92420120 

    24/408 AceView cDNA sequences (see all 408):

    AV648739 BQ007072 AW501555 BM788388 AK056748 BQ959398 AK022661 AK024498 
    BM925200 BC018269 AU125328 CN484604 BM561272 BU844563 CA312164 BQ675499 
    CD245391 BU682837 AK027800 AI298360 CR594495 AK055782 BM456908 BU508154 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16
    SP1:                          -     -     -     -           -                                         -                                                         
    SP2:                                                        -                                         -                             -     -     -     -         
    SP3:                    -     -     -     -     -           -                                         -                                                         
    SP4:              -     -     -     -     -     -                                                                                                               
    SP5:              -     -     -     -     -     -           -                                         -                                                         


    ECgene alternative splicing isoforms for PDLIM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDLIM2 expression in normal human tissues (normalized intensities)      PDLIM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTAAGTTT
    PDLIM2 Expression
    About this image


    PDLIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Spleen (Hematopoietic System)

    See PDLIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDLIM2

    SOURCE GeneReport for Unigene cluster: Hs.632034
        SABiosciences Custom PCR Arrays for PDLIM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDLIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PDLIM2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdlim21 , 5 PDZ and LIM domain 21, 5 79.73(n)1
    79.83(a)1
      14 (36.26 cM)5
    2130191  NM_145978.21  NP_666090.11 
     701642185 
    lizard
    (Anolis carolinensis)
    Reptilia PDLIM26
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343443.1(421176-501908)
    zebrafish
    (Danio rerio)
    Actinopterygii pdlim21 PDZ and LIM domain 2 (mystique) 54.66(n)
    49.4(a)
      560322  NM_001042766.2  NP_001036231.1 


    ENSEMBL Gene Tree for PDLIM2 (if available)
    TreeFam Gene Tree for PDLIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDLIM2 gene
    PDLIM42  PDLIM12  PDLIM32  
    6 SIMAP similar genes for PDLIM2 using alignment to 8 protein entries:     PDLI2_HUMAN (see all proteins):
    PDLIM5    FLJ00349    PDLIM3    SYNPO2    PDLIM7    PDLIM1

    PDLIM2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PDLIM2
    PGOHUM00000240884


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in PDLIM2 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392286651,2
    --20978074(+) TCATCC/TTTATA 2 -- us2k10--------
    rs1150194811,2
    C,F--20978085(+) GCCTGG/CGCTTC 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1903415071,2
    --22434523(+) GGGCAC/GGTCCA 1 -- us2k10--------
    rs1810143851,2
    --22434535(+) CCCATC/TCTGGC 1 -- us2k10--------
    rs1842933441,2
    --22434599(+) CAGCTA/CTTTTT 1 -- us2k10--------
    rs1880251191,2
    --22434624(+) ATTCCC/TTCATA 1 -- us2k10--------
    rs1385372641,2
    --22434644(+) AGGGCC/TGAGGC 1 -- us2k10--------
    rs78179431,2
    C--22434712(+) CTTCCC/TGCAGC 1 -- us2k10--------
    rs350347671,2
    C,F--22434727(+) AAACCC/GTCCAA 1 -- us2k110Minor allele frequency- G:0.13NA WA CSA EA 372
    rs774837721,2
    C,F--22434752(+) CACCAC/TGGTCC 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for PDLIM2 (22435792 - 22455538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PDLIM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736748CNV Deletion23290073
    dgv7762n71CNV Loss21882294
    nsv890673CNV Loss21882294
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609722    OMIM disorders: --

    5 diseases for PDLIM2:    About MalaCards
    adult t-cell leukemia    t-cell leukemia    breast cancer    leukemia
    colon cancer


    PDLIM2 for disorders           About GeneDecksing


    Export disorders for PDLIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDLIM2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with PDLIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth. (PubMed id 15659642)1, 2, 9 Loughran G....O'connor R. (2005)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    6. Epigenetic repression of PDZ-LIM domain-containing pr otein 2: implications for the biology and treatment of breast cancer. (PubMed id 20185823)1, 9 Qu Z....Xiao G. (2010)
    7. Human T-cell leukemia virus type I-mediated repressio n of PDZ-LIM domain-containing protein 2 involves DNA methylation but independe nt of the viral oncoprotein tax. (PubMed id 19794962)1, 9 Yan P....Xiao G. (2009)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Pdlim2 is a novel actin-regulating protein of podocyte foot processes. (PubMed id 21814175)1 Sistani L....Patrakka J. (2011)
    10. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64236 HGNC: 13992 AceView: DBC-1andPDLIM2 Ensembl:ENSG00000120913 euGenes: HUgn64236
    ECgene: PDLIM2 H-InvDB: PDLIM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDLIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDLIM2 gene:
    Search GeneIP for patents involving PDLIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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