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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDK3 Gene

protein-coding   GIFtS: 63
GCID: GC0XP024393

pyruvate dehydrogenase kinase, isozyme 3

(Previous names: pyruvate dehydrogenase kinase, isoenzyme 3 )
 Explore 5 diseases affiliated with
PDK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDK3    

Aliases
for PDK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pyruvate Dehydrogenase Kinase, Isozyme 31 2
Pyruvate Dehydrogenase Kinase, Isoenzyme 31 2
EC 2.7.11.23 8
Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 3, Mitochondrial2
PDHK33
Pyruvate Dehydrogenase Kinase Isoform 33

External Ids:    HGNC: 88111   Entrez Gene: 51652   Ensembl: ENSG000000679927   OMIM: 6025265   UniProtKB: Q151203   

Export aliases for PDK3 gene to outside databases

Previous GC identifers: GC0XP023311 GC0XP023142 GC0XP023685 GC0XP023844 GC0XP024243 GC0XP022225


Summaries
for PDK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDK3:
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the
overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the
tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose
metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and
phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate
dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is
predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: PDK3_HUMAN, Q15120
Function: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates
glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases
fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose
homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays
a role in the generation of reactive oxygen species

Gene Wiki entry for PDK3


Genomic Views
for PDK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDK3 gene promoter:
         AhR   C/EBPbeta   POU6F1 (c2)   CUTL1   AP-2gamma   Arnt   FOXL1   AREB6   FOXO4   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.12

PDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDK3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP024393:  view genomic region     (about GC identifiers)

Start:
 24,483,338 bp from pter      End:
 24,568,583 bp from pter
Size:
 85,246 bases      Orientation:
 plus strand

Proteins
for PDK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDK3_HUMAN, Q15120 (See protein sequence)
Recommended Name: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial precursor  
Size: 406 amino acids; 46939 Da
Subunit: Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric
pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide
acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3)
Subcellular location: Mitochondrion matrix
5 PDB 3D structures from and Proteopedia for PDK3:
1Y8N (3D)        1Y8O (3D)        1Y8P (3D)        2PNR (3D)        2Q8I (3D)    
Secondary accessions: B4DXG6
Alternative splicing: 2 isoforms:  Q15120-1   Q15120-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDK3: NX_Q15120

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15120

    • 4/11 DME Specific Peptides for PDK3 (Q15120) (see all 11)
     VYVPSHL  HIGSIDP  IYLKALS  GGGVPLR 

    PDK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135858.1  NP_005382.1  

    ENSEMBL proteins: 
     ENSP00000368460   ENSP00000387536  
    Reactome Protein details: Q15120
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    Uscn Proteins for PDK3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS7499431
    GO:0005759mitochondrial matrix TAS--


    PDK3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PDK3

    Protein Domains /
    Families
    for PDK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDK3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005467 Sig_transdc_His_kinase_core
     IPR003594 ATPase-like_ATP-bd
     IPR018955 BCDHK/PDK_N

    Graphical View of Domain Structure for InterPro Entry Q15120

    ProtoNet protein and cluster: Q15120

    1 Blocks protein family: IPB003594 ATP-binding region

    UniProtKB/Swiss-Prot: PDK3_HUMAN, Q15120
    Similarity: Belongs to the PDK/BCKDK protein kinase family
    Similarity: Contains 1 histidine kinase domain


    Function
    for PDK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDK3_HUMAN, Q15120
    Function: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates
    glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases
    fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose
    homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays
    a role in the generation of reactive oxygen species
    Catalytic activity: ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase
    (acetyl-transferring)] phosphate
    Enzyme regulation: Activated by interaction with DLAT. Inhibited by AZD7545, dichloroacetate and radicicol
    Induction: Up-regulated in response to hypoxia. Up-regulated in response to fatty acids

    Enzyme Number (IUBMB): EC 2.7.11.21 2

    miRNA
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    hsa-miR-411* hsa-miR-3938 hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-3921 hsa-miR-298 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmid: PDK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity ----
    GO:0004672protein kinase activity IDA15861126
    GO:0004674protein serine/threonine kinase activity IDA11486000
    GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA11486000
    GO:0005515protein binding IPI15861126


    PDK3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PDK3:
     Decreased substrate adherent c  Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for PDK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pyruvate metabolism
    		Pyruvate metabolism1.00
    		Regulation of pyruvate dehydrogenase (PDH) complex0.60
    2TCA Cycle
    		TCA Cycle1.00
    		Pyruvate metabolism and Citric Acid (TCA) cycle0.64
    3Metabolism
    		Metabolism1.00
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		The citric acid (TCA) cycle and respiratory electron transport0.72
    5Nanog in Mammalian ESC Pluripotency
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PDK3
        eNOS Signaling

    1 BioSystems Pathway for PDK3 
        TCA Cycle

    5        Reactome Pathways for PDK3
        Pyruvate metabolism
    Pyruvate metabolism and Citric Acid (TCA) cycle
    Metabolism
    The citric acid (TCA) cycle and respiratory electron transport
    Regulation of pyruvate dehydrogenase (PDH) complex



    PDK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/239 Interacting proteins for PDK3 (Q151202, 3 ENSP000003875364) via UniProtKB, MINT, STRING, and/or I2D (see all 239)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    DLATP105153, ENSP000002803464I2D: score=2 STRING: ENSP00000280346
    EGFRP005333, ENSP000002754934I2D: score=2 STRING: ENSP00000275493
    DLDP096222, ENSP000002054024MINT-8079030 STRING: ENSP00000205402
    PDHA1P085593, ENSP000003943824I2D: score=1 STRING: ENSP00000394382
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process IEA--
    GO:0006090pyruvate metabolic process TAS--
    GO:0006468protein phosphorylation ----
    GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate TAS--
    GO:0010906regulation of glucose metabolic process IMP--


    PDK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDK3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DCAMitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor[2156-56-1]

    3 HMDB Compounds for PDK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Hydrogen phosphateBiphosphate (see all 10)14066-19-4--

    2 DrugBank Compounds for PDK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dihydrolipoic Acid-- 462-20-4target--10592235
    Radicicol-- --target--10592235

    4 Novoseek chemical compound relationships for PDK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrolipoamide 77.8 1 11486000 (1)
    pyruvate 75.4 11 7499431 (2), 18718909 (2), 11485553 (1), 17532006 (1) (see all 7)
    adp 45.5 2 15861126 (2)
    atp 14.2 2 15861126 (2)

    Search CenterWatch for drugs/clinical trials and news about PDK3 

    Transcripts
    for PDK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDK3 gene (2 alternative transcripts): 
    NM_001142386.2  NM_005391.4  

    Unigene Cluster for PDK3:

    Pyruvate dehydrogenase kinase, isozyme 3
    Hs.296031  [show with all ESTs]
    Unigene Representative Sequence: NM_001142386
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379162(uc004dbg.3) ENST00000441463(uc004dbh.3) ENST00000493226


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    hsa-miR-411* hsa-miR-3938 hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-3921 hsa-miR-298 hsa-miR-508-5p
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK301965.1 BC015948.1 BC038512.2 L42452.1 

    8 DOTS entries:

    DT.306040  DT.441918  DT.311814  DT.109393  DT.75164534  DT.99974221  DT.121323578  DT.95153934 

    24/94 AceView cDNA sequences (see all 94):

    BX090714 AA335945 BU789702 AI080664 AI139184 BF939522 AI143333 AW594168 
    CR606226 CR626205 AI146557 AA156492 BU069975 CB054944 BX370602 BU163780 
    AW173304 N94761 N63567 R85384 AW263542 CB054943 AA648925 N63468 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PDK3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -                                                               
    SP2:                          -           -                                                   
    SP3:                                                                                          


    ECgene alternative splicing isoforms for PDK3

    Expression
    for PDK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAATTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PDK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDK3

    SOURCE GeneReport for Unigene cluster: Hs.296031

    UniProtKB/Swiss-Prot: PDK3_HUMAN, Q15120
    Tissue specificity: Found almost exclusively in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including PDK3: 
              Glucose Metabolism in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PDK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDK3 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pdk31 , 5 pyruvate dehydrogenase kinase, isoenzyme 31, 5 89.88(n)1
    97.11(a)1    		   X (41.34 cM)5
    2369001  NM_145630.21  NP_663605.11 
     937646075 
    chicken
    (Gallus gallus)    		 Aves PDK31 pyruvate dehydrogenase kinase, isozyme 3 81.94(n)
    92.86(a)    		   418595  NM_001006259.1  NP_001006259.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDK36
    		 --
    		 89(a)
    		 1 ↔ 1
    		 3(125949297-125989894)
    zebrafish
    (Danio rerio)    		 Actinopterygii pdk3a1 pyruvate dehydrogenase kinase, isozyme 3a 73.02(n)
    82.43(a)    		   560068  XM_683459.4  XP_688551.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pdk1 , 3 pyruvate dehydrogenase (lipoamide) kinase3
    Pyruvate dehydrogenase kinase1    		 59(a)3
    57.61(n)1
    59.89(a)1    		   359701  NM_001103770.11  NP_001097240.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK370.53
    pdhk-21    		 Phosphoprotein3
    Protein PDHK-21    		 53(a)3
    56.75(n)1
    54.16(a)1    		   III(8809765-8813134)3
    1762261  NM_066527.21  NP_498928.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PDK6
    		 pyruvate dehydrogenase kinase
    		 37(a)
    		 1 → many
    		 3(1990416-1992744)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 kinase, putative, expressed
    		 39(a)
    38(a)
    		 many ↔ many
    many ↔ many
    		 7(26480252-26484320)
    3(14524854-14529539)


    ENSEMBL Gene Tree for PDK3 (if available)
    TreeFam Gene Tree for PDK3 (if available) 

    Paralogs
    for PDK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDK3 gene
    BCKDK2  PDK12  PDK42  PDK22  
    3 SIMAP similar genes for PDK3 using alignment to 1 protein entry:     PDK3_HUMAN:
    PDK2    PDK4    PDK1

    PDK3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PDK3
    PGOHUM00000248255


    Genomic Variants
    for PDK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/888 NCBI SNPs in PDK3 are shown (see all 888)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1838247911,2
    		--24481383(+) AGAAAG/TATCAG 2 -- us2k10--------
    rs1874243401,2
    		--24481390(+) TCAGCA/GCTTTG 2 -- us2k10--------
    rs22145621,2
    		C--24482102(+) GCTGCA/CTAAAC 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs583492601,2
    		C--24482277(+) TTGCC-/AAAAAA 2 -- us2k10--------
    rs1919632251,2
    		--24482337(+) ATTCAC/TTCATA 2 -- us2k10--------
    rs1856595721,2
    		--24482374(+) AGCCCG/TGAGTT 2 -- us2k10--------
    rs1395738451,2
    		--24482636(+) GGGTAC/TGAAAG 2 -- us2k10--------
    rs1906075771,2
    		--24482676(+) TTCCAA/GTGGTA 2 -- us2k10--------
    rs1998786851,2
    		--24482691(+) GGGGT-/GGGGGG 2 -- us2k10--------
    rs1810777221,2
    		C,--24482809(+) TGGTGA/GGGGGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDK3 (24483338 - 24568583 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PDK3: --
    Locus Specific Mutation Databases (LSDB): PDK3

    3 SABiosciences Cancer Mutation PCR Assays for PDK3:
    Cosmic IdAA Change
    78288p.V193M
    12894p.S362*
    21025p.E219A
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDK3
    DNA2.0 Custom Variant and Variant Library Synthesis for PDK3

    Disorders / Diseases
    for PDK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDK3 for disorders           About GeneDecksing

    OMIM gene information: 602526    OMIM disorders: --

    5 diseases for PDK3:    About MalaCards
    periventricular nodular heterotopia    heterotopia    hypoxia    retinitis
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PDK3:
    Periventricular nodular heterotopia

    Export disorders for PDK3 gene to outside databases

    Publications
    for PDK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDK3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with PDK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversity of the pyruvate dehydrogenase kinase gene family in humans. (PubMed id 7499431)1, 2, 3, 9 Gudi R.... Popov K.M. (1995)
    2. Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex. (PubMed id 15861126)1, 2, 9 Kato M.... Chuang D.T. (2005)
    3. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. (PubMed id 18718909)1, 2, 9 Lu C.W....Tsai S.J. (2008)
    4. Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex. (PubMed id 11978179)1, 2, 9 Tuganova A....Popov K.M. (2002)
    5. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. (PubMed id 11486000)1, 2, 9 Korotchkina L.G. and Patel M.S. (2001)
    6. Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications. (PubMed id 17532006)1, 2, 9 Devedjiev Y....Vassylyev D.G. (2007)
    7. Inactivation of the HIF-1alpha/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants. (PubMed id 22865452)1, 2 Kluza J.... Marchetti P. (2012)
    8. Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. (PubMed id 17683942)1, 2 Kato M.... Chuang D.T. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Marked differences between two isoforms of human pyruvate dehydrogenase kinase. (PubMed id 10748134)1, 2 Baker J.C....Roche T.E. (2000)

    External Searches for PDK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5165 HGNC: 8811 AceView: PDK3 Ensembl:ENSG00000067992 euGenes: HUgn5165
    ECgene: PDK3 H-InvDB: PDK3

    Other Databases showing PDK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PDK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDK3 gene:
    Search GeneIP for patents involving PDK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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