PDK2 Gene
protein-coding GIFtS: 65
GCID: GC17P048172
|
|
pyruvate dehydrogenase kinase, isozyme 2(Previous names: pyruvate dehydrogenase kinase, isoenzyme 2 )
| |
Aliases
for PDK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pyruvate Dehydrogenase Kinase, Isozyme 21 2 | | PDKII3 | | PDHK21 2 3 | | PDH Kinase 23 | | Pyruvate Dehydrogenase Kinase, Isoenzyme 21 2 | | Pyruvate Dehydrogenase Kinase Isoform 23 | | EC 2.7.11.23 8 | | EC 2.7.118 | | Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 2, Mitochondrial2 | | |
Export aliases for PDK2 gene to outside databasesPrevious GC identifers: GC17P047981 GC17P050654 GC17P048514 GC17P048647 GC17P045527 GC17P043540 |
Summaries
for PDK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PDK2:
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvatedehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression ofthis gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multipleisoforms have been observed for this gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119Function: Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism andhomeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvatedehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulatesaerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvatedehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin.Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrientavailability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normalblood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cellproliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis
Gene Wiki entry for PDK2
|
Genomic Views
for PDK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDK2 gene promoter:
SRF SRF (504 AA) XBP-1 Nkx2-5 NF-AT NF-AT4 NF-AT2 HOXA5 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33PDK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P048172: view genomic region
(about GC identifiers)
Start:
|
48,172,101 bp from pter |
End:
|
48,189,516 bp from pter |
Size:
|
17,416 bases |
Orientation:
|
plus strand |
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Proteins
for PDK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119 (See
protein sequence)Recommended Name: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor Size: 407 amino acids; 46154 Da
Subunit: Homodimer, and heterodimer with PDK1. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and ispart of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1),dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3)
Subcellular location: Mitochondrion matrix
6 PDB 3D structures from  and Proteopedia  for PDK2:2BTZ (3D)
2BU2 (3D)
2BU5 (3D)
2BU6 (3D)
2BU7 (3D)
2BU8 (3D)
Secondary accessions: A8K3A7 B3KNW0 Q6P515 Q9BS05Alternative splicing: 2 isoforms: Q15119-1 Q15119-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PDK2: NX_Q15119
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15119
4/14 DME Specific Peptides for PDK2 (Q15119) (see all 14)
PDK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001186827.1 NP_001186828.1 NP_001186829.1 NP_002602.2
ENSEMBL proteins: ENSP00000007708 ENSP00000427682 ENSP00000420927 ENSP00000425265 ENSP00000425615 ENSP00000421178 ENSP00000423310 Reactome Protein details: Q15119
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
PDK2 for ontologies About GeneDecksing
PDK2 Antibody Products:
Assay Products for PDK2: |
Protein
Domains /
Families
for PDK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDK2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15119ProtoNet protein and cluster: Q15119 1 Blocks protein family: IPB003594 ATP-binding region
UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119Similarity: Belongs to the PDK/BCKDK protein kinase familySimilarity: Contains 1 histidine kinase domain |
Function
for PDK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119Function: Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism andhomeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvatedehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulatesaerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvatedehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin.Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrientavailability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normalblood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cellproliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosisCatalytic activity: ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase(acetyl-transferring)] phosphateEnzyme regulation: Activity is enhanced by binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by ADP andpyruvate; these compounds interfere with DLAT binding and thereby inhibit kinase activity. Inhibited bydichloroacetate. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase activityInduction: Down-regulated by insulin. Up-regulated by reactive oxygen species and cigarette smoke extract Genatlas biochemistry entry for PDK2:pyruvate dehydrogenase kinase,isoenzyme 2
Enzyme Numbers (IUBMB): EC 2.7.11.21 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): PDK2 (NM_001199899) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDK2 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
PDK2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PDK2:
Animal Models:
Mouse knock-out Pdk2tm1Rhar for PDK2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Pdk2):
PDK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PDK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pyruvate metabolism | | | 2 | TCA Cycle | | | 3 | Metabolism | | | 4 | B Cell Receptor Signaling Pathway | | | 5 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PDK2
2  BioSystems Pathways for PDK2
5 
Reactome Pathways for PDK2
PDK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/18 Interacting proteins for PDK2 (Q151192, 3 ENSP000000077084) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
PDK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PDK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PDK2 for compounds About GeneDecksing
 Compounds for PDK2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| DCA | Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor | [2156-56-1] |
3 HMDB Compounds for PDK2 About this table
4 DrugBank Compounds for PDK2 About this table
10/19 Novoseek chemical compound relationships for PDK2 gene (see all 19) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pyruvate |
85.3 |
66 |
15491150 (5), 15491151 (3), 7499431 (2), 10748134 (2) (see all 30) |
| dichloroacetate |
80.3 |
15 |
19833728 (5), 10748134 (2), 17544412 (1), 17222789 (1) (see all 6) |
| dihydrolipoamide |
77.8 |
2 |
11486000 (1), 19833728 (1) |
| acetyl-coa |
62.1 |
4 |
18544047 (1), 15491151 (1), 17310282 (1) |
| adp |
59.1 |
16 |
15491150 (4), 19833728 (2), 15491151 (2), 17310282 (2) (see all 6) |
| atp |
44.2 |
15 |
15491150 (5), 15491151 (2), 18220414 (1), 12816949 (1) |
| glycogen |
43.5 |
3 |
15955060 (1), 18468620 (1), 12162751 (1) |
| alpha lipoic acid |
39 |
3 |
15512796 (2), 12816949 (1) |
| phosphatidylinositol |
34.9 |
2 |
15955060 (1), 10226025 (1) |
| fatty acid |
34.9 |
1 |
15955060 (1) |
Search CenterWatch for drugs/clinical trials and news about PDK2
|
Transcripts
for PDK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDK2 gene (4 alternative transcripts): NM_001199898.1 NM_001199899.1 NM_001199900.1 NM_002611.4 Unigene Cluster for PDK2: Pyruvate dehydrogenase kinase, isozyme 2 Hs.256667 [show with all ESTs]Unigene Representative Sequence: NM_00119989815 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000007708(uc002iqb.3) ENST00000508030 ENST00000503176(uc002iqc.3 uc021tzx.1)
ENST00000503614 ENST00000508960 ENST00000505897(uc021tzw.1) ENST00000505440
ENST00000511026 ENST00000512238 ENST00000515040 ENST00000510219 ENST00000506242
ENST00000503076 ENST00000512204 ENST00000506647
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): PDK2 (NM_001199899) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDK2 |
Additional cDNA sequence: AK055119.1 AK290522.1 AK293600.1 AK297089.1 BC005811.2 BC040478.1 BC063137.1 L42451.1 18 DOTS entries: DT.100788800 DT.40248082 DT.100788798 DT.120938098 DT.100748331 DT.92440189 DT.95118759 DT.120938103 DT.100752224 DT.101967512 DT.120938050 DT.120938052 DT.120938056 DT.120938062 DT.120938092 DT.120938243 DT.439416 DT.40112660 24/298 AceView cDNA sequences (see all 298): AA349451 AI911542 BM725684 NM_002611 CA488863 BE675684 BM665602 F26580 AI206585 F35762 AI638478 BQ901189 AK055119 BE326734 AI432138 AL525191 AI187114 R89688 AI522169 BM796660 AI140069 H12298 AU130309 AW070543
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PDK2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PDK2
|
Expression
for PDK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGCTCAGG
About this image
See PDK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDK2
SOURCE GeneReport for Unigene cluster: Hs.256667
UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119Tissue specificity: Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levelsin brain, kidney, pancreas and liver, and low levels in placenta and lung
SABiosciences Expression via Pathway-Focused PCR Arrays including PDK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDK2 |
Orthologs
for PDK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PDK2 gene from 7/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PDK26 |
-- |
92(a) |
1 ↔ 1 |
6(77270162-77293601) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX714085.12 |
-- |
74.14(n) |
|
BX714085.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc562092 |
similar to pyruvate dehydrogenase kinase, isoenzyme more |
74.94(n) |
|
393971 BC045993.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pdk3 |
pyruvate dehydrogenase (lipoamide) kinase |
56(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK370.53 |
Phosphoprotein |
51(a) |
|
III(8809765-8813134) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PDK6 |
pyruvate dehydrogenase kinase |
37(a) |
1 → many |
3(1990416-1992744) |
rice
(Oryza sativa) |
Liliopsida |
---- |
kinase, putative, expressed |
39(a)38(a) |
many ↔ manymany ↔ many |
7(26480252-26484320) 3(14524854-14529539) |
ENSEMBL Gene Tree for PDK2 (if available)
TreeFam Gene Tree for PDK2 (if available) |
Paralogs
for PDK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PDK2 gene
- BCKDK2 PDK42 PDK12 PDK32
4 SIMAP similar genes for PDK2 using alignment to 6 protein entries: PDK2_HUMAN (see all proteins):PDK4 PDK3 PDK1 BCKDK
PDK2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PDK2
PGOHUM00000259236
|
Genomic Variants
for PDK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDK2 (48172101 - 48189516 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PDK2
2 CNVs: 88524 77656 | 2 SABiosciences Cancer Mutation PCR Assays for PDK2: |
|
Disorders
/ Diseases
for PDK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDK2 for disorders About GeneDecksing
OMIM gene information: 602525
OMIM disorders: --
10  diseases for PDK2: About MalaCardspolycystic kidney disease polycystic kidney disease 2 kidney disease insulin resistance
squamous cell carcinoma homocysteine cervical cancer cervicitis
ischemia carcinoma
3 Novoseek disease relationships for PDK2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polycystic kidney diseases |
35.8 |
1 |
9175744 (1) |
| aids |
0 |
1 |
12816949 (1) |
| tumors |
0 |
2 |
17054779 (2) |
Human Genome Epidemiology (HuGE) Navigator: PDK2 (1 document)
Export disorders for PDK2 gene to outside databases
|
Publications
for PDK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDK2 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with PDK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversity of the pyruvate dehydrogenase kinase gene family in humans. (PubMed id 7499431)1, 2, 3, 9 Gudi R.... Popov K.M. (1995)
- Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP. (PubMed id 15491150)1, 2, 9 Bao H....Roche T.E. (2004)
- Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase. (PubMed id 12816949)1, 2, 9 Hiromasa Y. and Roche T.E. (2003)
- Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate. (PubMed id 19833728)1, 2, 9 Li J....Chuang D.T. (2009)
- Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2. (PubMed id 16517984)1, 2, 9 Hiromasa Y....Roche T.E. (2006)
- Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. (PubMed id 16401071)1, 2, 9 Knoechel T.R.... Brown D.G. (2006)
- p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2. (PubMed id 22123926)1, 2 Contractor T. and Harris C.R. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP. (PubMed id 15491151)1, 9 Bao H....Roche T.E. (2004)
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External Searches for PDK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PDK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PDK2 gene
(According to HUGE)
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Specialized Databases showing PDK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for PDK2 gene:
Search GeneIP for patents involving PDK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PDK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PDK2 | | OriGene shRNA RFP for PDK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDK2 | | | OriGene Protein Over-expression Lysate for PDK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDK2 | | OriGene 3'-UTR Clone for PDK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PDK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PDK2 | | OriGene Custom Protein Services for PDK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDK2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDK2 |
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| | | | Tocris compounds for PDK2 |
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 | | | PDK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDK2 |
|  |  |  | | | | ThermoFisher Antibodies for PDK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDK2 |
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