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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDK2 Gene

protein-coding   GIFtS: 67
GCID: GC17P048172

Pyruvate Dehydrogenase Kinase, Isozyme 2

(Previous names: pyruvate dehydrogenase kinase, isoenzyme 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pyruvate Dehydrogenase Kinase, Isozyme 21 2     EC 2.7.11.23 8
Pyruvate Dehydrogenase Kinase, Isoenzyme 21 2     Pyruvate Dehydrogenase, Lipoamide, Kinase Isozyme 2, Mitochondrial2
PDHK22 3     Pyruvate Dehydrogenase Kinase Isoform 23
PDKII2 3     EC 2.7.118
PDH Kinase 22 3     

External Ids:    HGNC: 88101   Entrez Gene: 51642   Ensembl: ENSG000000058827   OMIM: 6025255   UniProtKB: Q151193   

Export aliases for PDK2 gene to outside databases

Previous GC identifers: GC17P047981 GC17P050654 GC17P048514 GC17P048647 GC17P045527 GC17P043540


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDK2 Gene:
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates
pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex.
Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for PDK2 Gene: 
PDK2 (pyruvate dehydrogenase kinase, isozyme 2) is a protein-coding gene. Diseases associated with PDK2 include polycystic kidney disease, and kidney disease, and among its related super-pathways are Pyruvate metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein kinase activity and protein homodimerization activity. An important paralog of this gene is BCKDK.

UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119
Function: Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism and
homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate
dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle,
down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of
pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to
insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to
nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in
maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in
the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in
p53/TP53-mediated apoptosis

Gene Wiki entry for PDK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDK2 gene promoter:
         SRF   SRF (504 AA)   XBP-1   Nkx2-5   NF-AT   NF-AT4   NF-AT2   HOXA5   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

PDK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDK2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048172:  view genomic region     (about GC identifiers)

Start:
48,172,101 bp from pter      End:
48,189,516 bp from pter
Size:
17,416 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119 (See protein sequence)
Recommended Name: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor  
Size: 407 amino acids; 46154 Da
Subunit: Homodimer, and heterodimer with PDK1. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and
is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase
(E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3)
Subcellular location: Mitochondrion matrix
6 PDB 3D structures from and Proteopedia for PDK2:
2BTZ (3D)        2BU2 (3D)        2BU5 (3D)        2BU6 (3D)        2BU7 (3D)        2BU8 (3D)    
Secondary accessions: A8K3A7 B3KNW0 Q6P515 Q9BS05
Alternative splicing: 2 isoforms:  Q15119-1   Q15119-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDK2: NX_Q15119

Explore proteomics data for PDK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15119

  • 4/14 DME Specific Peptides for PDK2 (Q15119) (see all 14)
     VYVPSHL  HIGSIDP  TPSVQLV  IYLKALS 

    PDK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDK2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001186827.1  NP_001186828.1  NP_001186829.1  NP_002602.2  

    ENSEMBL proteins: 
     ENSP00000007708   ENSP00000427682   ENSP00000420927   ENSP00000425265   ENSP00000425615  
     ENSP00000421178   ENSP00000423310  
    Reactome Protein details: Q15119
    Human Recombinant Protein Products for PDK2: 
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    Novus Biologicals PDK2 Proteins
    Novus Biologicals PDK2 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PDK2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--

    PDK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: pyruvate dehydrogenase kinase, isozyme 2 
    PDHK family

    3 InterPro protein domains:
     IPR005467 Sig_transdc_His_kinase_core
     IPR003594 HATPase_ATP-bd
     IPR018955 BCDHK/PDK_N

    Graphical View of Domain Structure for InterPro Entry Q15119

    ProtoNet protein and cluster: Q15119

    1 Blocks protein domain: IPB003594 ATP-binding region

    UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119
    Similarity: Belongs to the PDK/BCKDK protein kinase family
    Similarity: Contains 1 histidine kinase domain


    PDK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDK2_HUMAN, Q15119
    Function: Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism and
    homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate
    dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle,
    down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of
    pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to
    insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to
    nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in
    maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in
    the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in
    p53/TP53-mediated apoptosis
    Catalytic activity: ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase
    (acetyl-transferring)] phosphate
    Enzyme regulation: Activity is enhanced by binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by ADP
    and pyruvate; these compounds interfere with DLAT binding and thereby inhibit kinase activity. Inhibited by
    dichloroacetate. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase
    activity
    Induction: Down-regulated by insulin. Up-regulated by reactive oxygen species and cigarette smoke extract

         Genatlas biochemistry entry for PDK2:
    pyruvate dehydrogenase kinase,isoenzyme 2

         Enzyme Numbers (IUBMB): EC 2.7.11.21 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10748134
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA19833728
    GO:0005515protein binding ----
    GO:0005524ATP binding IDA16401071
         
    PDK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PDK2:
     Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pdk2):
     muscle 

    PDK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdk2tm1Rhar for PDK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDK2 
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    SwitchGear 3'UTR luciferase reporter plasmidPDK2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Pyruvate metabolism
    Pyruvate metabolism0.60
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    Regulation of pyruvate dehydrogenase (PDH) complex0.60
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Metabolism
    Metabolism0.40
    5B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PDK2
        eNOS Signaling

    1 BioSystems Pathway for PDK2
        B Cell Receptor Signaling Pathway


    5        Reactome Pathways for PDK2
        Pyruvate metabolism
    Pyruvate metabolism and Citric Acid (TCA) cycle
    Metabolism
    The citric acid (TCA) cycle and respiratory electron transport
    Regulation of pyruvate dehydrogenase (PDH) complex



    PDK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for PDK2 (Q151192, 3 ENSP000000077084) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428582, 3, ENSP000003471844MINT-64223 I2D: score=4 STRING: ENSP00000347184
    ISOC2Q96AB32, 3, ENSP000000850684MINT-64225 I2D: score=4 STRING: ENSP00000085068
    HIC2Q96JB32, 3MINT-64224 I2D: score=4 
    DLATP105153, ENSP000002803464I2D: score=3 STRING: ENSP00000280346
    PDHXO003303, ENSP000002278684I2D: score=3 STRING: ENSP00000227868
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process IEA--
    GO:0006090pyruvate metabolic process TAS--
    GO:0006111regulation of gluconeogenesis ISS--
    GO:0006468protein phosphorylation TAS10748134
    GO:0006885regulation of pH ISS--

    PDK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PDK2

    3 HMDB Compounds for PDK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Hydrogen phosphateBiphosphate (see all 10)14066-19-4--

    4 DrugBank Compounds for PDK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (N-{4-[(ETHYLANILINO)SULFONYL]-2-METHYLPHENYL}-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE-- --target--10592235
    4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE-- --target--10592235

    10/19 Novoseek inferred chemical compound relationships for PDK2 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyruvate 85.3 66 15491150 (5), 15491151 (3), 7499431 (2), 10748134 (2) (see all 30)
    dichloroacetate 80.3 15 19833728 (5), 10748134 (2), 17544412 (1), 17222789 (1) (see all 6)
    dihydrolipoamide 77.8 2 11486000 (1), 19833728 (1)
    acetyl-coa 62.1 4 18544047 (1), 15491151 (1), 17310282 (1)
    adp 59.1 16 15491150 (4), 19833728 (2), 15491151 (2), 17310282 (2) (see all 6)
    atp 44.2 15 15491150 (5), 15491151 (2), 18220414 (1), 12816949 (1)
    glycogen 43.5 3 15955060 (1), 18468620 (1), 12162751 (1)
    alpha lipoic acid 39 3 15512796 (2), 12816949 (1)
    phosphatidylinositol 34.9 2 15955060 (1), 10226025 (1)
    fatty acid 34.9 1 15955060 (1)

    Search CenterWatch for drugs/clinical trials and news about PDK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for PDK2 gene (4 alternative transcripts): 
    NM_001199898.1  NM_001199899.1  NM_001199900.1  NM_002611.4  

    Unigene Cluster for PDK2:

    Pyruvate dehydrogenase kinase, isozyme 2
    Hs.256667  [show with all ESTs]
    Unigene Representative Sequence: NM_001199898
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000007708(uc002iqb.3) ENST00000508030 ENST00000503176(uc002iqc.3 uc021tzx.1)
    ENST00000503614 ENST00000508960 ENST00000505897(uc021tzw.1) ENST00000505440
    ENST00000511026 ENST00000512238 ENST00000515040 ENST00000510219 ENST00000506242
    ENST00000503076 ENST00000512204 ENST00000506647
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    Additional mRNA sequence: 

    AK055119.1 AK290522.1 AK293600.1 AK297089.1 BC005811.2 BC040478.1 BC063137.1 L42451.1 

    18 DOTS entries:

    DT.100788800  DT.40248082  DT.100788798  DT.120938098  DT.100748331  DT.92440189  DT.95118759  DT.100752224 
    DT.120938103  DT.101967512  DT.120938050  DT.120938052  DT.120938056  DT.120938062  DT.120938092  DT.120938243 
    DT.439416  DT.40112660 

    24/298 AceView cDNA sequences (see all 298):

    AI638478 BQ901189 AW070543 F35762 BE549815 BQ672109 AA746262 CA488863 
    AI140069 H12298 BM713523 BE675684 AL525191 AA654999 CB153458 AI432138 
    AI522169 AA349451 BU528580 R89688 AI206585 AI144174 AI187114 BM725684 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PDK2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -     -     -                 -                       -     -                 -     -                                             
    SP2:                                      -           -                       -     -                 -     -                                             
    SP3:                                                                                                                                                      
    SP4:                    -     -     -     -           -                                                                                                   
    SP5:                                      -           -                                                                                                   


    ECgene alternative splicing isoforms for PDK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDK2 expression in normal human tissues (normalized intensities)      PDK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCTCAGG
    PDK2 Expression
    About this image


    PDK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Skeletal Muscle (Muscoskeletal System)

    See PDK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDK2

    SOURCE GeneReport for Unigene cluster: Hs.256667

    UniProtKB/Swiss-Prot: PDK2_HUMAN, Q15119
    Tissue specificity: Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate
    levels in brain, kidney, pancreas and liver, and low levels in placenta and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including PDK2: 
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Glucose Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDK2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdk21 , 5 pyruvate dehydrogenase kinase, isoenzyme 21, 5 91.56(n)1
    97.54(a)1
      11 (59.01 cM)5
    186041  NM_133667.21  NP_598428.21 
     950262585 
    lizard
    (Anolis carolinensis)
    Reptilia PDK26
    Uncharacterized protein
    92(a)
    1 ↔ 1
    6(77269978-77334843)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX714085.12   -- 74.14(n)    BX714085.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562092 similar to pyruvate dehydrogenase kinase, isoenzyme more 74.94(n)   393971  BC045993.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pdk3 pyruvate dehydrogenase (lipoamide)
    kinase
    56(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK370.53 Phosphoprotein 51(a)   III(8809765-8813134)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PKP26
    Mitochondrial protein kinase that negatively regul...
    18(a)
    1 → many
    VII(392223-393698)


    ENSEMBL Gene Tree for PDK2 (if available)
    TreeFam Gene Tree for PDK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDK2 gene
    BCKDK2  PDK42  PDK12  PDK32  
    4 SIMAP similar genes for PDK2 using alignment to 6 protein entries:     PDK2_HUMAN (see all proteins):
    PDK4    PDK3    PDK1    BCKDK

    PDK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PDK2
    PGOHUM00000259236


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/417 SNPs in PDK2 are shown (see all 417)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381297751,2
    --43538515(+) CCTCGA/GCGAGG 2 -- us2k10--------
    rs1157111351,2
    C,F--48170148(+) TAATTT/ATATAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1174541571,2
    F--48170181(+) CTATGC/TTGCCC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1894883271,2
    --48170249(+) AGGGCA/CAGGTT 1 -- us2k10--------
    rs1930949121,2
    --48170276(+) TCTATA/GTATTA 1 -- us2k10--------
    rs765400771,2
    C,F--48170288(+) TCTGTG/ACACTT 1 -- us2k13Minor allele frequency- A:0.17CSA WA NA 240
    rs1470027441,2
    --48170565(+) AAGAGC/GTACCA 1 -- us2k10--------
    rs1436119121,2
    --48170686(+) TAAGGG/TGTCTT 3 -- us2k10--------
    rs1147555861,2
    F--48170747(+) GACCAG/AGAGAT 3 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1853992961,2
    --48170752(+) GGAGAG/TCTAAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDK2 (48172101 - 48189516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PDK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3226n71CNV Loss21882294
    nsv908588CNV Loss21882294
    dgv3225n71CNV Loss21882294
    nsv908590CNV Loss21882294
    dgv3227n71CNV Loss21882294

    2 SABiosciences Cancer Mutation PCR Assays for PDK2:
    Cosmic IdAA Change
    35788p.P182S
    13349p.G342R
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PDK2
    DNA2.0 Custom Variant and Variant Library Synthesis for PDK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602525    OMIM disorders: --

    7 diseases for PDK2:    About MalaCards
    polycystic kidney disease    kidney disease    insulin resistance    cervical cancer
    ischemia    cervicitis    squamous cell carcinoma


    PDK2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for PDK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycystic kidney diseases 35.8 1 9175744 (1)
    aids 0 1 12816949 (1)
    tumors 0 2 17054779 (2)

    Genetic Association Database (GAD): PDK2
    Human Genome Epidemiology (HuGE) Navigator: PDK2 (1 document)

    Export disorders for PDK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDK2 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with PDK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversity of the pyruvate dehydrogenase kinase gene family in humans. (PubMed id 7499431)1, 2, 3, 9 Gudi R.... Popov K.M. (1995)
    2. Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP. (PubMed id 15491150)1, 2, 9 Bao H....Roche T.E. (2004)
    3. Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase. (PubMed id 12816949)1, 2, 9 Hiromasa Y. and Roche T.E. (2003)
    4. Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate. (PubMed id 19833728)1, 2, 9 Li J....Chuang D.T. (2009)
    5. Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2. (PubMed id 16517984)1, 2, 9 Hiromasa Y....Roche T.E. (2006)
    6. Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. (PubMed id 16401071)1, 2, 9 Knoechel T.R.... Brown D.G. (2006)
    7. p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2. (PubMed id 22123926)1, 2 Contractor T. and Harris C.R. (2012)
    8. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5164 HGNC: 8810 AceView: PDK2 Ensembl:ENSG00000005882 euGenes: HUgn5164
    ECgene: PDK2 H-InvDB: PDK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDK2 gene:
    Search GeneIP for patents involving PDK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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