PDILT Gene
protein-coding GIFtS: 40
GCID: GC16M020370
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protein disulfide isomerase-like, testis expressed
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Aliases
for PDILT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Disulfide Isomerase-Like, Testis Expressed1 2 | | PDIA71 2 | | Protein Disulfide Isomerase Family A, Member 72 | | Protein Disulfide Isomerase-Like Protein Of The Testis2 | | Protein Disulfide-Isomerase-Like Protein Of The Testis2 |
Export aliases for PDILT gene to outside databasesPrevious GC identifers: GC16M020278 GC16M018907 |
Summaries
for PDILT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PDILT_HUMAN, Q8N807Function: Probable redox-inactive chaperone involved in spermatogenesis
|
Genomic Views
for PDILT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDILT gene promoter:
NF-1 AP-1 AP-4 CUTL1 YY1 PPAR-alpha HEN1 STAT3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDILT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDILT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.3PDILT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M020370: view genomic region
(about GC identifiers)
Start:
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20,370,492 bp from pter |
End:
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20,416,059 bp from pter |
Size:
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45,568 bases |
Orientation:
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minus strand |
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Proteins
for PDILT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDILT_HUMAN, Q8N807 (See
protein sequence)Recommended Name: Protein disulfide-isomerase-like protein of the testis precursor Size: 584 amino acids; 66657 Da
Subunit: Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1L and CLGN
Subcellular location: Endoplasmic reticulum
Secondary accessions: Q8IVQ5Explore the universe of human proteins at neXtProt for PDILT: NX_Q8N807
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N807
PDILT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777584.1
ENSEMBL proteins: ENSP00000305465 ENSP00000459161
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IEA | -- |
PDILT for ontologies About GeneDecksing
PDILT Antibody Products:
Assay Products for PDILT: |
Protein
Domains /
Families
for PDILT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDILT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N807ProtoNet protein and cluster: Q8N807 UniProtKB/Swiss-Prot: PDILT_HUMAN, Q8N807Domain: The thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue,suggesting that it lacks thioredoxin activitySimilarity: Belongs to the protein disulfide isomerase familySimilarity: Contains 1 thioredoxin domain |
Function
for PDILT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PDILT_HUMAN, Q8N807Function: Probable redox-inactive chaperone involved in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDILT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDILT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PDILT (NM_174924) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDILT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDILT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDILT |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016853 | isomerase activity |
IEA | -- |
PDILT for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Pdilttm1Osb for PDILT
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pdilt):
PDILT for phenotypes About GeneDecksing
|
Pathways & Interactions
for PDILT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDILT
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PDILT (Q8N8073 ENSP000003054654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
PDILT for ontologies About GeneDecksing
|
Drugs & Compounds
for PDILT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PDILT
Search CenterWatch for drugs/clinical trials and news about PDILT
|
Transcripts
for PDILT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDILT gene: NM_174924.1 Unigene Cluster for PDILT: Protein disulfide isomerase-like, testis expressed Hs.376025 [show with all ESTs]Unigene Representative Sequence: BC0426072 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302451(uc002dhc.1) ENST00000575561
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDILT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDILT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PDILT (NM_174924) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDILT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDILT |
Additional cDNA sequence: AK097476.1 BC042607.1 BC044936.1 1 DOTS entry: DT.99931057 5 AceView cDNA sequences: NM_174924 BC044936 BC042607 BI832163 AK097476
GeneLoc Exon Structure
|
Expression
for PDILT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDILT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PDILT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDILT
SOURCE GeneReport for Unigene cluster: Hs.376025
UniProtKB/Swiss-Prot: PDILT_HUMAN, Q8N807Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for PDILT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDILT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDILT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDILT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDILT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDILT |
Orthologs
for PDILT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PDILT gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for PDILT (if available)
TreeFam Gene Tree for PDILT (if available) |
Paralogs
for PDILT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PDILT gene
- PDIA62 PDIA22 PDIA52 PDIA42 TMX32 ERP272 DNAJC102 P4HB2
- TXNDC52 PDIA32
18/25 SIMAP similar genes for PDILT using alignment to 2 protein entries: PDILT_HUMAN (see all proteins)
(see all similar genes):C1orf143 RHBG RPS6KA5 SLC24A1 TUBA1C KIAA1651
DCAF17 NLN RQCD1 SH2B3 COQ5 EEF1E1
KIAA0101 ARIH1 IK NCKAP1L PFKFB3 RARS
PDILT for paralogs About GeneDecksing
|
Genomic Variants
for PDILT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDILT (20370492 - 20416059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDILT: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDILT |
|
Disorders
/ Diseases
for PDILT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDILT for disorders About GeneDecksing
1  disease for PDILT: About MalaCardskidney disease
Export disorders for PDILT gene to outside databases
|
Publications
for PDILT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDILT gene integrated from 9 sources:
(articles sorted by number of sources associating them with PDILT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum. (PubMed id 15475357)1, 2, 3 van Lith M....Benham A.M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. (PubMed id 17507649)2 van Lith M.... Benham A.M. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PDILT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PDILT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PDILT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDILT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PDILT | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PDILT gene:
Search GeneIP for patents involving PDILT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PDILT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PDILT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDILT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDILT | | | OriGene Protein Over-expression Lysate for PDILT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDILT | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDILT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDILT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PDILT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDILT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDILT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDILT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDILT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDILT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDILT |
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 |  |  |  | |
| | | | Search Tocris compounds for PDILT |
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 | | | PDILT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDILT |
|  |  |  | | | | Search ThermoFisher Antibodies for PDILT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDILT |
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