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Aliases for PDIK1L Gene

Aliases for PDIK1L Gene

  • PDLIM1 Interacting Kinase 1 Like 2 3 5
  • PDLIM1-Interacting Kinase 1-Like 3 4
  • EC 2.7.11.1 4 63
  • CLIK1L 3 4
  • Casein Kinase 3
  • STK35L2 3

External Ids for PDIK1L Gene

Previous GeneCards Identifiers for PDIK1L Gene

  • GC01P026310
  • GC01P026437
  • GC01P024691

Summaries for PDIK1L Gene

GeneCards Summary for PDIK1L Gene

PDIK1L (PDLIM1 Interacting Kinase 1 Like) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDIK1L Gene

Genomics for PDIK1L Gene

Regulatory Elements for PDIK1L Gene

Promoters for PDIK1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDIK1L on UCSC Golden Path with GeneCards custom track

Genomic Location for PDIK1L Gene

Chromosome:
1
Start:
26,111,165 bp from pter
End:
26,125,548 bp from pter
Size:
14,384 bases
Orientation:
Plus strand

Genomic View for PDIK1L Gene

Genes around PDIK1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDIK1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDIK1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDIK1L Gene

Proteins for PDIK1L Gene

  • Protein details for PDIK1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N165-PDK1L_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PDIK1L
    Protein Accession:
    Q8N165
    Secondary Accessions:
    • B2R777
    • D3DPK2
    • Q5T2I0
    • Q8NDB3

    Protein attributes for PDIK1L Gene

    Size:
    341 amino acids
    Molecular mass:
    38546 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDIK1L Gene

Proteomics data for PDIK1L Gene at MOPED

Post-translational modifications for PDIK1L Gene

  • Ubiquitination at Lys 187
  • Modification sites at PhosphoSitePlus

Other Protein References for PDIK1L Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PDIK1L

Domains & Families for PDIK1L Gene

Gene Families for PDIK1L Gene

Protein Domains for PDIK1L Gene

Suggested Antigen Peptide Sequences for PDIK1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N165

UniProtKB/Swiss-Prot:

PDK1L_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PDIK1L: view

Function for PDIK1L Gene

Molecular function for PDIK1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for PDIK1L Gene

Gene Ontology (GO) - Molecular Function for PDIK1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PDIK1L: view
genes like me logo Genes that share phenotypes with PDIK1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDIK1L

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDIK1L Gene

Localization for PDIK1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDIK1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDIK1L Gene COMPARTMENTS Subcellular localization image for PDIK1L gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PDIK1L Gene

Pathways & Interactions for PDIK1L Gene

SuperPathways for PDIK1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDIK1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PDIK1L Gene

Drugs & Compounds for PDIK1L Gene

No Compound Related Data Available

Transcripts for PDIK1L Gene

Unigene Clusters for PDIK1L Gene

PDLIM1 interacting kinase 1 like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDIK1L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for PDIK1L Gene

GeneLoc Exon Structure for
PDIK1L
ECgene alternative splicing isoforms for
PDIK1L

Expression for PDIK1L Gene

mRNA expression in normal human tissues for PDIK1L Gene

SOURCE GeneReport for Unigene cluster for PDIK1L Gene Hs.468801

mRNA Expression by UniProt/SwissProt for PDIK1L Gene

Q8N165-PDK1L_HUMAN
Tissue specificity: Expressed in liver, kidney, pancreas, spleen, thymus and prostate.
genes like me logo Genes that share expression patterns with PDIK1L: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PDIK1L Gene

Orthologs for PDIK1L Gene

This gene was present in the common ancestor of animals.

Orthologs for PDIK1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDIK1L 35
  • 97.36 (n)
  • 99.12 (a)
PDIK1L 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDIK1L 35
  • 97.07 (n)
  • 99.41 (a)
PDIK1L 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdik1l 35
  • 93.35 (n)
  • 99.41 (a)
Pdik1l 16
Pdik1l 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDIK1L 35
  • 100 (n)
  • 100 (a)
PDIK1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdik1l 35
  • 92.96 (n)
  • 99.71 (a)
oppossum
(Monodelphis domestica)
Mammalia PDIK1L 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDIK1L 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDIK1L 35
  • 83.68 (n)
  • 96.19 (a)
PDIK1L 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDIK1L 36
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.16831 35
pdik1l 35
  • 72.43 (n)
  • 82.99 (a)
pdik1l 36
  • 83 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zyg-1 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8364 36
  • 51 (a)
OneToMany
Species with no ortholog for PDIK1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PDIK1L Gene

ENSEMBL:
Gene Tree for PDIK1L (if available)
TreeFam:
Gene Tree for PDIK1L (if available)

Paralogs for PDIK1L Gene

Paralogs for PDIK1L Gene

(1) SIMAP similar genes for PDIK1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PDIK1L: view

Variants for PDIK1L Gene

Sequence variations from dbSNP and Humsavar for PDIK1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2802306 -- 26,111,007(+) GCGCC(A/G)TGGGC upstream-variant-2KB
rs2802327 -- 26,116,245(+) TGGCT(C/G/T)ACGCC intron-variant
rs2783636 -- 26,110,899(+) ACTGT(C/T)CAGCC upstream-variant-2KB
rs2783637 -- 26,112,735(+) TAAAG(C/T)AGTGG intron-variant
rs2783681 -- 26,114,716(+) TAGAT(A/C)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDIK1L Gene

Variant ID Type Subtype PubMed ID
nsv511129 CNV Loss 21212237
nsv819393 CNV Loss 19587683

Variation tolerance for PDIK1L Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDIK1L Gene

HapMap Linkage Disequilibrium report
PDIK1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDIK1L Gene

Disorders for PDIK1L Gene

Relevant External Links for PDIK1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDIK1L

No disorders were found for PDIK1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDIK1L Gene

Publications for PDIK1L Gene

  1. Molecular cloning and characterization of a novel human kinase gene, PDIK1L. (PMID: 14631099) Guo L. … Mao Y. (J. Genet. 2003) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  4. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. (PMID: 19756140) Goyal P. … Siess W. (PLoS ONE 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PDIK1L Gene

Sources for PDIK1L Gene

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