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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDIA4 Gene

protein-coding GIFtS: 57
GCID: GC07M148700

protein disulfide isomerase family A, member 4

(Previous name: protein disulfide isomerase-associated 4 )

Explore 15 diseases affiliated with
PDIA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Disulfide Isomerase Family A, Member 4¹ ²		ER Protein 70² ³
ERP70¹ ² ³		ER Protein 72² ³
ERP72¹ ² ³		EC 5.3.4.1³ ⁸
Protein Disulfide Isomerase-Associated 4¹ ²		Protein Disulfide Isomerase Related Protein (Calcium-Binding Protein, Intestinal-Related)²
Endoplasmic Reticulum Resident Protein 70² ³		Protein Disulfide-Isomerase A4²
Endoplasmic Reticulum Resident Protein 72² ³		ERp70³
ERp-72² ³		ERp72³

External Ids:	HGNC: 30167¹	Entrez Gene: 9601²	Ensembl: ENSG00000155660⁷	UniProtKB: P13667³

Export aliases for PDIA4 gene to outside databases

Previous GC identifers: GC07M148138 GC07M148331 GC07M142778

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDIA4 gene promoter:
NF-YA CBF-C Max CBF-A CBF-B CP1A CP1C NF-Y c-Myc CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDIA4 promoter sequence

Search SABiosciences Chromatin IP Primers for PDIA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDIA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q35

PDIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDIA4 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M148700: view genomic region (about GC identifiers)

Start:	148,700,154 bp from pter	End:	148,725,782 bp from pter
Size:	25,629 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 148,038,519-148,064,131

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDIA4_HUMAN, P13667 (See protein sequence)

Recommended Name: Protein disulfide-isomerase A4 precursor

Size: 645 amino acids; 72932 Da

Subunit: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6,

PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX

Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

Caution: Was originally (PubMed:2549034) thought to be a deoxycytidine kinase

1 PDB 3D structure from and Proteopedia for PDIA4:

3IDV (3D)

Secondary accessions: A8K4K6 Q549T6

Explore the universe of human proteins at neXtProt for PDIA4: NX_P13667

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13667

4/10 DME Specific Peptides for PDIA4 (P13667) (see all 10)

GFPTIYF

PEYEKAA

DPKKDVL

LPLVGHRK

PDIA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004902.1

ENSEMBL proteins:

ENSP00000286091 ENSP00000408628

Human Recombinant Protein Products for PDIA4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals PDIA4 Proteins Novus Biologicals PDIA4 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PDIA4
	Uscn Proteins for PDIA4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	--	--
GO:0005788	endoplasmic reticulum lumen	IEA	--
GO:0009986	cell surface	IDA	19995400
GO:0042470	melanosome	IEA	--

PDIA4 for ontologies About GeneDecksing

PDIA4 Antibody Products:

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	ThermoFisher Antibody for PDIA4

Assay Products for PDIA4:

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	Uscn ELISAs and CLIAs for PDIA4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDIA4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR005746 Thioredoxin

IPR017068 Protein_diS-isomerase_A4

IPR012336 Thioredoxin-like_fold

IPR005788 Disulphide_isomerase

IPR013766 Thioredoxin_domain

Graphical View of Domain Structure for InterPro Entry P13667

ProtoNet protein and cluster: P13667

1 Blocks protein family: IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: PDIA4_HUMAN, P13667

Similarity: Belongs to the protein disulfide isomerase family

Similarity: Contains 3 thioredoxin domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PDIA4_HUMAN, P13667

Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins

Enzyme Number (IUBMB): EC 5.3.4.1¹ ²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003756	protein disulfide isomerase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0009055	electron carrier activity	IEA	--
GO:0015035	protein disulfide oxidoreductase activity	IEA	--

PDIA4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PDIA4:

Increased G2M DNA content

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PDIA4

miRNA Products:		OriGene 3'-UTR Clone: PDIA4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDIA4
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate PDIA4 (see all 12):
		hsa-miR-576-3p hsa-miR-3163 hsa-miR-3607-3p hsa-miR-16-1* hsa-miR-3171 hsa-miR-378b hsa-miR-422a hsa-miR-377

		SwitchGear 3'UTR luciferase reporter plasmid: PDIA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDIA4 (see all 7) OriGene shRNA RFP: PDIA4 OriGene siRNA: PDIA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDIA4
		Sirion Biotech Custom design and validation of potent shRNA sequences against PDIA4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PDIA4
			Sirion Biotech Customized adenovirus for overexpression of PDIA4 Sirion Biotech Customized adenovirus for potent knockdown of PDIA4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDIA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDIA4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PDIA4 (NM_004911)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDIA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDIA4

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		Sirion Biotech Customized stable knockdown cell line services for PDIA4 Sirion Biotech Customized inducible knockdown cell line services for PDIA4 Sirion Biotech Customized stable overexpressing cell line services for PDIA4 Sirion Biotech Customized inducible overexpressing cell line services for PDIA4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDIA4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

Translational Control

Translational Control

1.00

Insulin receptor recycling

Vibrio cholerae infection

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for PDIA4

Translational Control

2 Kegg Pathways (Kegg details for PDIA4):

	Protein processing in endoplasmic reticulum
	Vibrio cholerae infection

PDIA4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PDIA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/132 Interacting proteins for PDIA4 (P13667^{1, 2, 3} ENSP00000286091⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006662	glycerol ether metabolic process	IEA	--
GO:0009306	protein secretion	TAS	2295602
GO:0045454	cell redox homeostasis	IEA	--

PDIA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PDIA4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PDIA4
5 Novoseek chemical compound relationships for PDIA4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sucrose	25	1	7916014 (1)
atp	23.7	4	7916014 (1), 19628287 (1), 8710914 (1), 8294423 (1)
arginine	5.39	1	14659757 (1)
glucose	0	2	10731687 (1), 19628287 (1)
calcium	0	1	8294423 (1)

Search CenterWatch for drugs/clinical trials and news about PDIA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDIA4 gene:

NM_004911.4

Unigene Cluster for PDIA4:

Protein disulfide isomerase family A, member 4

Hs.93659 [show with all ESTs]

Unigene Representative Sequence: NM_004911

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000286091(uc003wff.2) ENST00000466592 ENST00000413966

miRNA Products:		OriGene 3'-UTR Clone: PDIA4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDIA4
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate PDIA4 (see all 12):
		hsa-miR-576-3p hsa-miR-3163 hsa-miR-3607-3p hsa-miR-16-1* hsa-miR-3171 hsa-miR-378b hsa-miR-422a hsa-miR-377

		SwitchGear 3'UTR luciferase reporter plasmid: PDIA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDIA4 (see all 7) OriGene shRNA RFP: PDIA4 OriGene siRNA: PDIA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDIA4
		Sirion Biotech Custom design and validation of potent shRNA sequences against PDIA4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDIA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDIA4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PDIA4 (NM_004911)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDIA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDIA4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDIA4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDIA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDIA4

Additional cDNA sequence:

AK290971.1 AK313299.1 BC000425.2 BC001928.1 BC006344.2 BC011754.2

16 DOTS entries:

DT.100794843 DT.85101938 DT.100794844 DT.91943250 DT.100794845 DT.92454428 DT.95172387 DT.121043818

DT.92454446 DT.95172389 DT.121043844 DT.97864794 DT.95172392 DT.95340568 DT.121043843 DT.95172397

24/557 AceView cDNA sequences (see all 557):

BE313248 BQ676775 BM738862 BQ929046 BU552561 BQ957313 BC000425 BQ897839

BM728892 BM663207 AA687839 BM783582 AA227036 BE878882 BM781729 BM802499

BM758656 C01152 AA291431 AI499659 BQ877523 BF219924 AW002017 BU543944

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PDIA4 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b
SP1:																					-
SP2:																					-
SP3:							-						-
SP4:																					-
SP5:			-

ECgene alternative splicing isoforms for PDIA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDIA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGACTGAA

About this image

PDIA4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PDIA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDIA4

SOURCE GeneReport for Unigene cluster: Hs.93659

SABiosciences Expression via Pathway-Focused PCR Arrays including PDIA4:

Neurotoxicity in human mouse rat

Osmotic Stress in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDIA4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDIA4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDIA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDIA4 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PDIA4¹	protein disulfide isomerase family A, member 4	74.47(n) 80.29(a)		420785 NM_001006370.1 NP_001006370.1
lizard (Anolis carolinensis)	Reptilia	PDIA4⁶	--	77(a)	1 ↔ 1	6(53455042-53471349)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5570²	Xenopus laevis transcribed sequence with moderate similarity more	80.5(n)		BJ617042.1
zebrafish (Danio rerio)	Actinopterygii	wufd20c07²	wufd20c07	76.25(n)		327282 BC063979.1
worm (Caenorhabditis elegans)	Secernentea	C14B9.2¹	Protein C14B9.2	54.88(n) 49.32(a)		176147 NM_066374.6 NP_498775.2
thale cress (Arabidopsis thaliana)	eudicotyledons	PDIL1-2¹	protein disulfide-isomerase 2	49.66(n) 41.69(a)		844087 NM_106400.2 NP_177875.1
rice (Oryza sativa)	Liliopsida	Os.10985²	Oryza sativa Pdi mRNA for protein disulfide isomerase, more	77.58(n)		AK068268.1

ENSEMBL Gene Tree for PDIA4 (if available)
TreeFam Gene Tree for PDIA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PDIA4 gene

PDIA6² PDIA2² PDIA5² TMX3² ERP27² DNAJC10² P4HB² TXNDC5²

PDIA3² PDILT²

2 SIMAP similar genes for PDIA4 using alignment to 2 protein entries: PDIA4_HUMAN (see all proteins):

PDIA3 P4HB

PDIA4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111311043^1,2		--	148699677(+)	`GGGTAG/AGTCCA`	1	--	ds500¹		1		CSA	2
rs11981448^1,2	H	--	148699703(+)	`CCTGGC/GAGACC`	1	--	ds500¹		0	--	--	--	--
rs182705070^1,2		--	148699722(+)	`CCTGCA/CCCCAC`	1	--	ds500¹		0	--	--	--	--
rs10671079^1,2	C	--	148699778(+)	`CAAGGAT/-TTTCA`	1	--	ds500¹		2		CSA	4
rs114801262^1,2	F	--	148699819(+)	`CAGCTG/AAGTGA`	1	--	ds500¹		1		WA	118
rs6464928^1,2	C,F,A,H	--	148699922(+)	`CTTATG/AGCACA`	1	--	ds500¹		15		NS EA NA WA CSA	790
rs199905071^1,2		--	148700081(+)	`AGGGC-/TTTAGC`	1	--	ds500¹		0	--	--	--	--
rs11414114^1,2	C	--	148700083(+)	`GGCTTC/-AGCTA`	1	--	ds500¹		2		CSA	4
rs74834636^1,2	F	--	148700111(+)	`ACCCCG/AAGGCT`	1	--	ds500¹		1		WA	118
rs146862320^1,2		--	148700169(+)	`TAATCA/GTGTTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PDIA4 (148700154 - 148725782 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDIA4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDIA4

DNA2.0 Custom Variant and Variant Library Synthesis for PDIA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PDIA4 for disorders About GeneDecksing

15 diseases for PDIA4: About MalaCards

von willebrand's disease esophageal squamous cell carcinoma squamous cell carcinoma congenital hypothyroidism

hypothyroidism goiter cholera hepatocellular carcinoma

esophagitis carcinoma breast cancer ischemia

myeloma hepatitis malaria

1 Novoseek disease relationship for PDIA4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	9.56	1	15171721 (1)

Human Genome Epidemiology (HuGE) Navigator: PDIA4 (1 document)

Export disorders for PDIA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PDIA4 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with PDIA4)

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Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. (PubMed id 2002068)^{1, 2, 3} Huang S.H....Holcenberg J. (1991)
Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. (PubMed id 2549034)^{1, 2, 3} Huang S.-H.... Holcenberg J.S. (1989)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)^{1, 2} Basrur V.... Appella E. (2003)
A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. (PubMed id 12475965)^{1, 2} Meunier L....Hendershot L.M. (2002)
Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. (PubMed id 9694898)^{1, 9} Linnik K.M. and Herscovitz H. (1998)
An antibody that binds a neutrophil membrane protein, ERp72, primes human neutrophils for enhanced oxidative metabolism in response to formyl-methionyl-leucyl-phenylalanine. Implications for ERp72 in the signal transduction pathway for neutrophil priming. (PubMed id 1318337)^{1, 9} Weisbart R.H. (1992)
ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. (PubMed id 2295602)^{1, 9} Mazzarella R.A....Green M. (1990)
A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72. (PubMed id 18620548)^{1, 9} Chen W....Kamata T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9601	HGNC: 30167	AceView: ERP70	Ensembl:ENSG00000155660	euGenes: HUgn9601
ECgene: PDIA4	Kegg: 9601	H-InvDB: PDIA4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PDIA4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PDIA4 gene
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Patent Information for PDIA4 gene:
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PDIA4 Gene

protein disulfide isomerase family A, member 4

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PDIA4 Gene

protein disulfide isomerase family A, member 4

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