Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDIA4 Gene

Aliases for PDIA4 Gene

  • Protein Disulfide Isomerase Family A Member 4 2 3 5
  • Protein Disulfide Isomerase Family A, Member 4 2 3
  • Endoplasmic Reticulum Resident Protein 70 3 4
  • Endoplasmic Reticulum Resident Protein 72 3 4
  • Protein Disulfide Isomerase-Associated 4 2 3
  • ER Protein 70 3 4
  • ER Protein 72 3 4
  • EC 4 63
  • ERp-72 3 4
  • ERP70 3 4
  • ERP72 3 4
  • Protein Disulfide Isomerase Related Protein (Calcium-Binding Protein, Intestinal-Related) 3
  • Testicular Tissue Protein Li 137 3

External Ids for PDIA4 Gene

Previous GeneCards Identifiers for PDIA4 Gene

  • GC07M148138
  • GC07M148331
  • GC07M148700
  • GC07M142778

Summaries for PDIA4 Gene

GeneCards Summary for PDIA4 Gene

PDIA4 (Protein Disulfide Isomerase Family A Member 4) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Insulin receptor recycling. GO annotations related to this gene include poly(A) RNA binding and isomerase activity. An important paralog of this gene is PDIA3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDIA4 Gene

Genomics for PDIA4 Gene

Regulatory Elements for PDIA4 Gene

Enhancers for PDIA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDIA4 on UCSC Golden Path with GeneCards custom track

Promoters for PDIA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDIA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDIA4 Gene

149,003,051 bp from pter
149,028,690 bp from pter
25,640 bases
Minus strand

Genomic View for PDIA4 Gene

Genes around PDIA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDIA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDIA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDIA4 Gene

Proteins for PDIA4 Gene

  • Protein details for PDIA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein disulfide-isomerase A4
    Protein Accession:
    Secondary Accessions:
    • A8K4K6
    • Q549T6

    Protein attributes for PDIA4 Gene

    645 amino acids
    Molecular mass:
    72932 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Three dimensional structures from OCA and Proteopedia for PDIA4 Gene

neXtProt entry for PDIA4 Gene

Proteomics data for PDIA4 Gene at MOPED

Post-translational modifications for PDIA4 Gene

  • Ubiquitination at Lys 103, Lys 141, Lys 256, Lys 294, and Lys 391
  • Glycosylation at Thr 503
  • Modification sites at PhosphoSitePlus

Other Protein References for PDIA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDIA4 (PDIA4)
  • Abcam antibodies for ERp72

Domains & Families for PDIA4 Gene

Gene Families for PDIA4 Gene

Suggested Antigen Peptide Sequences for PDIA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
  • Contains 3 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with PDIA4: view

Function for PDIA4 Gene

Molecular function for PDIA4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Catalyzes the rearrangement of -S-S- bonds in proteins.

Enzyme Numbers (IUBMB) for PDIA4 Gene

genes like me logo Genes that share phenotypes with PDIA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDIA4

miRNA for PDIA4 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDIA4 Gene

Localization for PDIA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDIA4 Gene

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269 PubMed:17081065}.

Subcellular locations from

Jensen Localization Image for PDIA4 Gene COMPARTMENTS Subcellular localization image for PDIA4 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with PDIA4: view

Pathways & Interactions for PDIA4 Gene

genes like me logo Genes that share pathways with PDIA4: view

Pathways by source for PDIA4 Gene

1 Cell Signaling Technology pathway for PDIA4 Gene
1 Qiagen pathway for PDIA4 Gene

Gene Ontology (GO) - Biological Process for PDIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009306 protein secretion TAS 2295602
GO:0034976 response to endoplasmic reticulum stress IBA --
genes like me logo Genes that share ontologies with PDIA4: view

No data available for SIGNOR curated interactions for PDIA4 Gene

Drugs & Compounds for PDIA4 Gene

(4) Drugs for PDIA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PDIA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PDIA4: view

Transcripts for PDIA4 Gene

Unigene Clusters for PDIA4 Gene

Protein disulfide isomerase family A, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDIA4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PDIA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDIA4 Gene

mRNA expression in normal human tissues for PDIA4 Gene

mRNA differential expression in normal tissues according to GTEx for PDIA4 Gene

This gene is overexpressed in Liver (x7.2).

Protein differential expression in normal tissues from HIPED for PDIA4 Gene

This gene is overexpressed in Lymph node (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDIA4 Gene

SOURCE GeneReport for Unigene cluster for PDIA4 Gene Hs.93659

genes like me logo Genes that share expression patterns with PDIA4: view

Protein tissue co-expression partners for PDIA4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PDIA4 Gene

Orthologs for PDIA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDIA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDIA4 35
  • 86.31 (n)
  • 86.94 (a)
ERP70 36
  • 87 (a)
(Canis familiaris)
Mammalia PDIA4 35
  • 85.1 (n)
  • 84.89 (a)
PDIA4 36
  • 86 (a)
(Mus musculus)
Mammalia Pdia4 35
  • 86.27 (n)
  • 88.3 (a)
Pdia4 16
Pdia4 36
  • 89 (a)
(Pan troglodytes)
Mammalia PDIA4 35
  • 99.28 (n)
  • 98.91 (a)
PDIA4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pdia4 35
  • 85.38 (n)
  • 87.09 (a)
(Monodelphis domestica)
Mammalia PDIA4 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PDIA4 36
  • 84 (a)
(Gallus gallus)
Aves PDIA4 35
  • 75.06 (n)
  • 82.36 (a)
PDIA4 36
  • 79 (a)
(Anolis carolinensis)
Reptilia PDIA4 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdia4 35
  • 69.87 (n)
  • 75.3 (a)
Str.16310 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5570 35
(Danio rerio)
Actinopterygii pdia4 35
  • 70.55 (n)
  • 76.2 (a)
wufd20c07 35
pdia4 36
  • 73 (a)
(Caenorhabditis elegans)
Secernentea C14B9.2 35
  • 54.99 (n)
  • 50 (a)
C14B9.2 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EUG1 36
  • 25 (a)
PDI1 36
  • 29 (a)
PDI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PDIL1-2 35
  • 49.92 (n)
  • 42.01 (a)
(Hordeum vulgare)
Liliopsida Hv.3992 35
(Oryza sativa)
Liliopsida Os.10985 35
Os11g0199200 35
  • 51.84 (n)
  • 40.41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4873 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.373 36
  • 57 (a)
Species with no ortholog for PDIA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDIA4 Gene

Gene Tree for PDIA4 (if available)
Gene Tree for PDIA4 (if available)

Paralogs for PDIA4 Gene

Paralogs for PDIA4 Gene

(2) SIMAP similar genes for PDIA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDIA4: view

Variants for PDIA4 Gene

Sequence variations from dbSNP and Humsavar for PDIA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2290971 - 149,015,000(+) GAGGC(A/G)TCCAG reference, missense
rs6947874 -- 149,006,757(+) AAGGA(C/G)GGCCT intron-variant
rs6948711 -- 149,024,141(+) ACTTG(A/G)GAGGC intron-variant
rs1020940 -- 149,017,719(+) ttatc(A/G)aaata intron-variant
rs1052549 -- 149,003,450(-) CCTTT(G/T)CCAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDIA4 Gene

Variant ID Type Subtype PubMed ID
nsv528358 CNV Loss 19592680
nsv889402 CNV Loss 21882294

Variation tolerance for PDIA4 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDIA4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDIA4 Gene

Disorders for PDIA4 Gene

Relevant External Links for PDIA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PDIA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDIA4 Gene

Publications for PDIA4 Gene

  1. Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. (PMID: 2002068) Huang S.H. … Holcenberg J. (J. Biol. Chem. 1991) 2 3 4 67
  2. A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72. (PMID: 18620548) Chen W. … Kamata T. (Biochem. J. 2008) 3 23
  3. Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. (PMID: 12397072) Zhang J. … Herscovitz H. (J. Biol. Chem. 2003) 3 23
  4. A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion. (PMID: 10887119) Allen S. … Daly M.E. (Blood 2000) 3 23
  5. Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. (PMID: 9694898) Linnik K.M. … Herscovitz H. (J. Biol. Chem. 1998) 3 23

Products for PDIA4 Gene

Sources for PDIA4 Gene