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PDIA4 Gene

protein-coding   GIFtS: 64
GCID: GC07M148700

Protein Disulfide Isomerase Family A, Member 4

(Previous name: protein disulfide isomerase-associated 4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Disulfide Isomerase Family A, Member 41 2     ER Protein 702 3
Protein Disulfide Isomerase-Associated 41 2     ER Protein 722 3
Endoplasmic Reticulum Resident Protein 702 3     EC 5.3.4.13 8
Endoplasmic Reticulum Resident Protein 722 3     Protein Disulfide Isomerase Related Protein (Calcium-Binding Protein,
Intestinal-Related)2
ERP702 3     Protein Disulfide-Isomerase A42
ERP722 3     ERp703
ERp-722 3     ERp723

External Ids:    HGNC: 301671   Entrez Gene: 96012   Ensembl: ENSG000001556607   UniProtKB: P136673   

Export aliases for PDIA4 gene to outside databases

Previous GC identifers: GC07M148138 GC07M148331 GC07M142778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PDIA4 Gene:
PDIA4 (protein disulfide isomerase family A, member 4) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and protein disulfide isomerase activity. An important paralog of this gene is ERP27.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDIA4 gene promoter:
         NF-YA   CBF-C   Max   CBF-A   CBF-B   CP1A   CP1C   NF-Y   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDIA4 promoter sequence
   Search Chromatin IP Primers for PDIA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDIA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

PDIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDIA4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M148700:  view genomic region     (about GC identifiers)

Start:
148,700,154 bp from pter      End:
148,725,782 bp from pter
Size:
25,629 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 148,038,519-148,064,131     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PDIA4_HUMAN, P13667 (See protein sequence)
Recommended Name: Protein disulfide-isomerase A4 precursor  
Size: 645 amino acids; 72932 Da
Subunit: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4,
PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX
Caution: Was originally (PubMed:2549034) thought to be a deoxycytidine kinase
1 PDB 3D structure from and Proteopedia for PDIA4:
3IDV (3D)    
Secondary accessions: A8K4K6 Q549T6

Explore the universe of human proteins at neXtProt for PDIA4: NX_P13667

Explore proteomics data for PDIA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103, Lys141, Lys256, Lys294, Lys391
  • Glycosylation2 at Thr503
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDIA4 (P13667) (see all 10)
     GFPTIYF  PEYEKAA  DPKKDVL  LPLVGHRK 


    See PDIA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004902.1  
    ENSEMBL proteins: 
     ENSP00000286091   ENSP00000408628  

    PDIA4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for PDIA4
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    OriGene Custom Protein Services for PDIA4
    GenScript Custom Purified and Recombinant Proteins Services for PDIA4
    Novus Biologicals PDIA4 Proteins
    Novus Biologicals PDIA4 Lysates
    Sino Biological Recombinant Protein for PDIA4
    Sino Biological Cell Lysate for PDIA4
    ProSpec Recombinant Protein for PDIA4
    Cloud-Clone Corp. Proteins for PDIA4

     
    Search eBioscience for Proteins for PDIA4 

     
    antibodies-online proteins for PDIA4 (21 products) 

     
    antibodies-online peptides for PDIA4

    PDIA4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibody for PDIA4
    antibodies-online antibodies for PDIA4 (58 products) 

    PDIA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PDIA4
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    Cloud-Clone Corp. ELISAs for PDIA4
    Cloud-Clone Corp. CLIAs for PDIA4
    Search eBioscience for ELISAs for PDIA4 
    antibodies-online kits for PDIA4 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDI: Protein disulfide isomerases

    Selected InterPro protein domains (see all 7):
     IPR005746 Thioredoxin
     IPR017068 Protein_diS-isomerase_A4
     IPR012336 Thioredoxin-like_fold
     IPR005788 Disulphide_isomerase
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry P13667

    ProtoNet protein and cluster: P13667

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: PDIA4_HUMAN, P13667
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 3 thioredoxin domains


    Find genes that share domains with PDIA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDIA4_HUMAN, P13667
    Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins

         Enzyme Number (IUBMB): EC 5.3.4.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity ISS--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI--
    GO:0015035protein disulfide oxidoreductase activity IEA--
    GO:0016853isomerase activity ----
         
    Find genes that share ontologies with PDIA4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDIA4:
     Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PDIA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDIA4:
    hsa-mir-335-5p (MIRT018114), hsa-mir-92a-3p (MIRT049739), hsa-mir-877-3p (MIRT036839)

    Block miRNA regulation of human, mouse, rat PDIA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDIA4 (see all 12):
    hsa-miR-576-3p hsa-miR-3163 hsa-miR-3607-3p hsa-miR-16-1* hsa-miR-3171 hsa-miR-378b hsa-miR-422a hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidPDIA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDIA4
    Predesigned siRNA for gene silencing in human, mouse, rat PDIA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDIA4

    Clone
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    OriGene clones in human, mouse for PDIA4 (see all 7)
    OriGene ORF clones in mouse, rat for PDIA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDIA4 (NM_004911)
    Sino Biological Human cDNA Clone for PDIA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDIA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDIA4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PDIA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDIA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDIA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDIA4_HUMAN, P13667: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IBA--
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0009986cell surface IDA19995400
    GO:0042470melanosome IEA--

    Find genes that share ontologies with PDIA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDIA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Vibrio cholerae infection0.40
    2Insulin secretion
    Thyroid hormone synthesis0.36
    3Translational Control
    Translational Control
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with PDIA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PDIA4
        Cholera Infection

    1 Cell Signaling Technology (CST) Pathway for PDIA4
        Translational Control



    3 Kegg Pathways  (Kegg details for PDIA4):
        Protein processing in endoplasmic reticulum
    Thyroid hormone synthesis
    Vibrio cholerae infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDIA4: 
              Neurotoxicity in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PDIA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDIA4 (P136671, 2, 3 ENSP000002860914) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IBA--
    GO:0006662glycerol ether metabolic process IEA--
    GO:0009306protein secretion TAS2295602
    GO:0034976response to endoplasmic reticulum stress IBA--
    GO:0045454cell redox homeostasis IEA--

    Find genes that share ontologies with PDIA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDIA4

    5 Novoseek inferred chemical compound relationships for PDIA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sucrose 25 1 7916014 (1)
    atp 23.7 4 7916014 (1), 19628287 (1), 8710914 (1), 8294423 (1)
    arginine 5.39 1 14659757 (1)
    glucose 0 2 10731687 (1), 19628287 (1)
    calcium 0 1 8294423 (1)



    Find genes that share compounds with PDIA4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDIA4 gene: 
    NM_004911.4  

    Unigene Cluster for PDIA4:

    Protein disulfide isomerase family A, member 4
    Hs.93659  [show with all ESTs]
    Unigene Representative Sequence: NM_004911
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286091(uc003wff.2) ENST00000466592 ENST00000413966
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDIA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDIA4 (see all 12):
    hsa-miR-576-3p hsa-miR-3163 hsa-miR-3607-3p hsa-miR-16-1* hsa-miR-3171 hsa-miR-378b hsa-miR-422a hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidPDIA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDIA4
    Predesigned siRNA for gene silencing in human, mouse, rat PDIA4
    Clone
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    OriGene clones in human, mouse for PDIA4 (see all 7)
    OriGene ORF clones in mouse, rat for PDIA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDIA4 (NM_004911)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDIA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDIA4
    Primer
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    OriGene qPCR primer pairs and template standards for PDIA4
    OriGene qSTAR qPCR primer pairs in human, mouse for PDIA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDIA4
      QuantiTect SYBR Green Assays in human, mouse, rat PDIA4
      QuantiFast Probe-based Assays in human, mouse, rat PDIA4

    Additional mRNA sequence: 

    AK290971.1 AK313299.1 BC000425.2 BC001928.1 BC006344.2 BC011754.2 

    16 DOTS entries:

    DT.100794843  DT.85101938  DT.100794844  DT.91943250  DT.100794845  DT.92454428  DT.95172387  DT.121043818 
    DT.92454446  DT.95172389  DT.121043844  DT.97864794  DT.95172392  DT.95340568  DT.121043843  DT.95172397 

    Selected AceView cDNA sequences (see all 557):

    CB854189 CB267650 AI688770 BF056551 BQ020174 BQ936459 AW673691 BG171310 
    AA419117 BQ957313 AA327066 BI832624 AA227048 H85766 BF195626 AI816495 
    BM757819 BM474820 BM663207 BP359208 AW002017 BM728892 BM781729 BF223104 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDIA4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:                                                              -                                       
    SP2:                                                              -                                       
    SP3:                    -                 -                                                               
    SP4:                                                              -                                       
    SP5:        -                                                                                             


    ECgene alternative splicing isoforms for PDIA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDIA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGACTGAA
    PDIA4 Expression
    About this image


    PDIA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PDIA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDIA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93659
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDIA4: 
              Neurotoxicity in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDIA4
    OriGene qSTAR qPCR primer pairs in human, mouse for PDIA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDIA4
    QuantiTect SYBR Green Assays in human, mouse, rat PDIA4
    QuantiFast Probe-based Assays in human, mouse, rat PDIA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDIA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDIA4 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdia41 , 5 protein disulfide isomerase associated 41, 5 86.27(n)1
    88.3(a)1
      6 (22.94 cM)5
    123041  NM_009787.21  NP_033917.21 
     477961425 
    chicken
    (Gallus gallus)
    Aves PDIA41 protein disulfide isomerase family A, member 4 75.06(n)
    82.36(a)
      420785  NM_001006370.1  NP_001006370.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDIA46
    protein disulfide isomerase family A, member 4
    77(a)
    1 ↔ 1
    6(53454784-53471855)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55702 Xenopus laevis transcribed sequence with moderate similarity more 80.5(n)    BJ617042.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd20c072 wufd20c07 76.25(n)   327282  BC063979.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C14B9.21 C14B9.2 54.99(n)
    50(a)
      176147  NM_066374.7  NP_498775.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PDI1(YCL043C)4 Protein disulfide isomerase; multifunctional protein more   --   3(50221-48653) 850314  NP_009887.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PDIL1-21 PDIL1-2 49.92(n)
    42.01(a)
      844087  NM_106400.2  NP_177875.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109852 Oryza sativa Pdi mRNA for protein disulfide isomerase, more 77.58(n)    AK068268.1 


    ENSEMBL Gene Tree for PDIA4 (if available)
    TreeFam Gene Tree for PDIA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDIA4 gene
    ERP272  TMX32  P4HB2  PDIA22  ERP442  PDIA32  PDILT2  
    2 SIMAP similar genes for PDIA4 using alignment to 2 protein entries:     PDIA4_HUMAN (see all proteins):
    PDIA3    P4HB

    Find genes that share paralogs with PDIA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDIA4 (see all 797)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113110431,2
    F--148699677(+) GGGTAG/AGTCCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs119814481,2
    H--148699703(+) CCTGGC/GAGACC 1 -- ds50010--------
    rs1827050701,2
    --148699722(+) CCTGCA/CCCCAC 1 -- ds50010--------
    rs351298851,2
    C--148699779(+) AAGGT-/ATTTCAC 1 -- ds50010--------
    rs1148012621,2
    C,F--148699819(+) CAGCTG/AAGTGA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs64649281,2
    C,F,A,H--148699922(+) CTTATG/AGCACA 1 -- ds500115Minor allele frequency- A:0.24NS EA NA WA CSA 790
    rs1999050711,2
    --148700081(+) AGGGC-/TTTAGC 1 -- ds50010--------
    rs353040051,2
    C--148700084(+) GCTTA-/CGCTAC 1 -- ds50010--------
    rs748346361,2
    F--148700111(+) ACCCCG/AAGGCT 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1468623201,2
    --148700169(+) TAATCA/GTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PDIA4 (148700154 - 148725782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PDIA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv889402CNV Loss21882294
    nsv528358CNV Loss19592680

    Human Gene Mutation Database (HGMD): PDIA4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDIA4
    DNA2.0 Custom Variant and Variant Library Synthesis for PDIA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PDIA4           About GenesLikeMe

    1 Novoseek inferred disease relationship for PDIA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 9.56 1 15171721 (1)

    Genetic Association Database (GAD): PDIA4
    Human Genome Epidemiology (HuGE) Navigator: PDIA4 (1 document)

    Export disorders for PDIA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDIA4 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with PDIA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. (PubMed id 2002068)1, 2, 3 Huang S.H....Holcenberg J. (J. Biol. Chem. 1991)
    2. Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. (PubMed id 2549034)1, 2, 3 Huang S.-H.... Holcenberg J.S. (J. Biol. Chem. 1989)
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (J. Proteome Res. 2003)
    7. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. (PubMed id 12475965)1, 2 Meunier L.... Hendershot L.M. (Mol. Biol. Cell 2002)
    8. Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. (PubMed id 9694898)1, 9 Linnik K.M. and Herscovitz H. (J. Biol. Chem. 1998)
    9. An antibody that binds a neutrophil membrane protein, ERp72, primes human neutrophils for enhanced oxidative metabolism in response to formyl-methionyl-leucyl-phenylalanine. Implications for ERp72 in the signal transduction pathway for neutrophil priming. (PubMed id 1318337)1, 9 Weisbart R.H. (J. Immunol. 1992)
    10. ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. (PubMed id 2295602)1, 9 Mazzarella R.A....Green M. (J. Biol. Chem. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9601 HGNC: 30167 AceView: ERP70 Ensembl:ENSG00000155660 euGenes: HUgn9601
    ECgene: PDIA4 Kegg: 9601 H-InvDB: PDIA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDIA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDIA4 gene:
    Search GeneIP for patents involving PDIA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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