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Aliases for PDIA3 Gene

Aliases for PDIA3 Gene

  • Protein Disulfide Isomerase Family A, Member 3 2 3
  • GRP58 3 4 6
  • Endoplasmic Reticulum Resident Protein 57 3 4
  • Endoplasmic Reticulum Resident Protein 60 3 4
  • Protein Disulfide Isomerase-Associated 3 2 3
  • Glucose Regulated Protein, 58kDa 2 3
  • 58 KDa Glucose-Regulated Protein 3 4
  • Disulfide Isomerase ER-60 3 4
  • 58 KDa Microsomal Protein 3 4
  • ER Protein 57 3 4
  • ER Protein 60 3 4
  • EC 4 63
  • ERp57 3 4
  • ERp60 3 4
  • P58 3 4
  • Epididymis Secretory Sperm Binding Protein Li 93n 3
  • Epididymis Secretory Protein Li 269 3
  • Protein Disulfide-Isomerase A3 3
  • Endoplasmic Reticulum P58 3
  • Phospholipase C-Alpha 3
  • HEL-S-269 3
  • HEL-S-93n 3
  • HsT17083 3
  • PI-PLC 3
  • ERp61 3
  • GRP57 3
  • ER60 3

External Ids for PDIA3 Gene

Previous HGNC Symbols for PDIA3 Gene

  • GRP58

Previous GeneCards Identifiers for PDIA3 Gene

  • GC15P041826
  • GC15P044038
  • GC15P020861

Summaries for PDIA3 Gene

Entrez Gene Summary for PDIA3 Gene

  • This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDIA3 Gene

PDIA3 (Protein Disulfide Isomerase Family A, Member 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include electron carrier activity and protein disulfide oxidoreductase activity. An important paralog of this gene is TMX3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDIA3 Gene

Genomics for PDIA3 Gene

Regulatory Elements for PDIA3 Gene

Genomic Location for PDIA3 Gene

43,746,392 bp from pter
43,773,279 bp from pter
26,888 bases
Plus strand

Genomic View for PDIA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDIA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDIA3 Gene

Proteins for PDIA3 Gene

  • Protein details for PDIA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein disulfide-isomerase A3
    Protein Accession:
    Secondary Accessions:
    • Q13453
    • Q14255
    • Q8IYF8
    • Q9UMU7

    Protein attributes for PDIA3 Gene

    505 amino acids
    Molecular mass:
    56782 Da
    Quaternary structure:
    • Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with the S and Z variants of SERPINA1.

    Three dimensional structures from OCA and Proteopedia for PDIA3 Gene

neXtProt entry for PDIA3 Gene

Proteomics data for PDIA3 Gene at MOPED

Post-translational modifications for PDIA3 Gene

  • Ubiquitination at Lys94, Lys104, Lys296, Lys305, Lys335, and Lys362
  • Glycosylation at Thr102, Thr452, Ser456, and Thr485
  • Modification sites at PhosphoSitePlus

Other Protein References for PDIA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDIA3 (GRP58)

Domains for PDIA3 Gene

Gene Families for PDIA3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
  • Contains 2 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with PDIA3: view

Function for PDIA3 Gene

Molecular function for PDIA3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Catalyzes the rearrangement of -S-S- bonds in proteins.

Enzyme Numbers (IUBMB) for PDIA3 Gene

Gene Ontology (GO) - Molecular Function for PDIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0004197 cysteine-type endopeptidase activity TAS 9399589
GO:0004629 phospholipase C activity TAS 3398923
GO:0005515 protein binding IPI 15896298
GO:0015035 protein disulfide oxidoreductase activity --
genes like me logo Genes that share ontologies with PDIA3: view
genes like me logo Genes that share phenotypes with PDIA3: view

Animal Models for PDIA3 Gene

MGI Knock Outs for PDIA3:

Animal Model Products

miRNA for PDIA3 Gene

miRTarBase miRNAs that target PDIA3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDIA3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PDIA3 Gene

Localization for PDIA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDIA3 Gene

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for PDIA3 Gene COMPARTMENTS Subcellular localization image for PDIA3 gene
Compartment Confidence
endoplasmic reticulum 4
cytoskeleton 2
golgi apparatus 2
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PDIA3: view

Pathways for PDIA3 Gene

genes like me logo Genes that share pathways with PDIA3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PDIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006457 protein folding TAS --
GO:0006508 proteolysis TAS 9399589
GO:0006606 protein import into nucleus TAS 7487104
genes like me logo Genes that share ontologies with PDIA3: view

Drugs for PDIA3 Gene

(15) Novoseek inferred chemical compound relationships for PDIA3 Gene

Compound -log(P) Hits PubMed IDs
castanospermine 64.6 2
cysteine 27.3 2
polysaccharide 27 2
carnitine 18.1 4
inositol 1.18 1
genes like me logo Genes that share compounds with PDIA3: view

Transcripts for PDIA3 Gene

Unigene Clusters for PDIA3 Gene

Protein disulfide isomerase family A, member 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDIA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDIA3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: -
SP2: - -
SP3: -
SP5: - - -

Relevant External Links for PDIA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDIA3 Gene

mRNA expression in normal human tissues for PDIA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDIA3 Gene

SOURCE GeneReport for Unigene cluster for PDIA3 Gene Hs.591095

mRNA Expression by UniProt/SwissProt for PDIA3 Gene

Tissue specificity: Detected in the flagellum and head region of spermatozoa (at protein level).
genes like me logo Genes that share expressions with PDIA3: view

Expression partners for PDIA3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PDIA3 Gene

Orthologs for PDIA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDIA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDIA3 35
  • 92.61 (n)
  • 95.25 (a)
PDIA3 36
  • 95 (a)
(Canis familiaris)
Mammalia PDIA3 35
  • 92.52 (n)
  • 95.71 (a)
-- 36
  • 85 (a)
-- 36
  • 96 (a)
(Mus musculus)
Mammalia Pdia3 35
  • 90.17 (n)
  • 93.07 (a)
Pdia3 16
Pdia3 36
  • 93 (a)
(Pan troglodytes)
Mammalia PDIA3 35
  • 99.74 (n)
  • 100 (a)
PDIA3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pdia3 35
  • 89.57 (n)
  • 92.08 (a)
(Monodelphis domestica)
Mammalia PDIA3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PDIA3 36
  • 90 (a)
(Gallus gallus)
Aves PDIA3 35
  • 77.52 (n)
  • 83.51 (a)
PDIA3 36
  • 81 (a)
(Anolis carolinensis)
Reptilia PDIA3 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75624 35
pdia3 35
  • 73.85 (n)
  • 77.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia grp58-prov 35
(Danio rerio)
Actinopterygii Dr.6501 35
pdia3 35
  • 72.46 (n)
  • 78.11 (a)
pdia3 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007393 35
  • 53.91 (n)
  • 49.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta ERp60 35
  • 53.86 (n)
  • 51.24 (a)
ERp60 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea pdi-3 35
  • 55.93 (n)
  • 49.1 (a)
pdi-3 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EUG1 36
  • 25 (a)
PDI1 36
  • 28 (a)
EUG1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.651 35
(Oryza sativa)
Liliopsida Os04g0436300 35
  • 49.42 (n)
  • 38.98 (a)
(Triticum aestivum)
Liliopsida Ta.796 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7969 36
  • 46 (a)
Species with no ortholog for PDIA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PDIA3 Gene

Gene Tree for PDIA3 (if available)
Gene Tree for PDIA3 (if available)

Paralogs for PDIA3 Gene

Paralogs for PDIA3 Gene

(9) SIMAP similar genes for PDIA3 Gene using alignment to 6 proteins: Pseudogenes for PDIA3 Gene

genes like me logo Genes that share paralogs with PDIA3: view

Variants for PDIA3 Gene

Sequence variations from dbSNP and Humsavar for PDIA3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1053492 -- 43,769,604(+) GGTCA(C/T)TGTAA reference, synonymous-codon
rs1054070 -- 43,771,344(+) ATAAT(C/T)TGAAT utr-variant-3-prime
rs1054088 -- 43,771,376(+) TGTTT(C/T)TTAGC utr-variant-3-prime
rs1054183 -- 43,771,489(+) ATTTT(A/C/T)TAATT utr-variant-3-prime
rs2277530 -- 43,769,727(+) ATTTG(G/T)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDIA3 Gene

Variant ID Type Subtype PubMed ID
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850
dgv2372n71 CNV Gain 21882294
dgv743e1 CNV Complex 17122850
esv33661 CNV Loss 17666407

Relevant External Links for PDIA3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDIA3 Gene

Disorders for PDIA3 Gene

(7) Novoseek inferred disease relationships for PDIA3 Gene

Disease -log(P) Hits PubMed IDs
leukemia basophilic 34.2 1
shock 19 7
melanoma 8.94 2
tumors 2.78 7
gastric cancer 0 1

Relevant External Links for PDIA3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PDIA3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PDIA3 Gene

Publications for PDIA3 Gene

  1. cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase. (PMID: 7487104) Bourdi M. … Pohl L.R. (Arch. Biochem. Biophys. 1995) 3 4 23
  2. Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha). (PMID: 8624847) Charnock-Jones D.S. … Smith S.K. (Int. J. Biochem. Cell Biol. 1996) 3 4 23
  3. Structures of the human gene for the protein disulfide isomerase- related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21. (PMID: 9205111) Koivunen P. … Kivirikko K.I. (Genomics 1997) 3 4 23
  4. Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin. (PMID: 12052826) Leach M.R. … Williams D.B. (J. Biol. Chem. 2002) 3 23
  5. Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. (PMID: 12239218) Kang S.J. … Cresswell P. (J. Biol. Chem. 2002) 3 23

Products for PDIA3 Gene

Sources for PDIA3 Gene

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