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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDIA3 Gene

protein-coding   GIFtS: 63
GCID: GC15P044038

protein disulfide isomerase family A, member 3

(Previous names: glucose regulated protein, 58kDa, protein disulfide isomerase-associated...)
(Previous symbol: GRP58)
 Explore 34 diseases affiliated with
PDIA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDIA3    

Aliases
for PDIA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Disulfide Isomerase Family A, Member 31 2     Endoplasmic Reticulum Resident Protein 602 3
GRP581 2 3 5     58 KDa Glucose-Regulated Protein2 3
ERp571 2 3     58 KDa Microsomal Protein2 3
ERp601 2 3     ER Protein 572 3
ERp611 2     ER Protein 602 3
GRP571 2     EC 5.3.4.13 8
HsT170831 2     ER602
P581 2     Endoplasmic Reticulum P582
PI-PLC1 2     Phospholipase C-Alpha2
Glucose Regulated Protein, 58kDa1 2     Protein Disulfide-Isomerase A32
Protein Disulfide Isomerase-Associated 31 2     ERP573
Disulfide Isomerase ER-602 3     ERP603
Endoplasmic Reticulum Resident Protein 572 3     P581 2

External Ids:    HGNC: 46061   Entrez Gene: 29232   Ensembl: ENSG000001670047   OMIM: 6020465   UniProtKB: P301013   

Export aliases for PDIA3 gene to outside databases

Previous GC identifers: GC15P041826 GC15P020861


Summaries
for PDIA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDIA3:
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and
calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase;
however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought
that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their
glycoprotein substrates. (provided by RefSeq, Jul 2008)




Genomic Views
for PDIA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDIA3 gene promoter:
         AML1a   AP-1   ATF-2   E47   FOXL1   CREB   c-Myb   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDIA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDIA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDIA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15

PDIA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDIA3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044038:  view genomic region     (about GC identifiers)

Start:
 44,038,590 bp from pter      End:
 44,065,477 bp from pter
Size:
 26,888 bases      Orientation:
 plus strand

Proteins
for PDIA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDIA3_HUMAN, P30101 (See protein sequence)
Recommended Name: Protein disulfide-isomerase A3 precursor  
Size: 505 amino acids; 56782 Da
Subunit: Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked
heterodimers with TAPBP. Interacts with ERP27 and CANX
Subcellular location: Endoplasmic reticulum lumen (By similarity). Melanosome. Note=Identified by mass spectrometry in
melanosome fractions from stage I to stage IV
Mass spectrometry: Mass=54265.22; Method=MALDI; Range=25-505; Source=PubMed:11840567;
Caution: Was originally thought to be a phosphatidylinositol 4,5-bisphosphate phosphodiesterase type I (phospholipase
C-alpha)
4 PDB 3D structures from and Proteopedia for PDIA3:
2ALB (3D)        2DMM (3D)        2H8L (3D)        3F8U (3D)    
Secondary accessions: Q13453 Q14255 Q8IYF8 Q9UMU7

Explore the universe of human proteins at neXtProt for PDIA3: NX_P30101

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30101

    • 4/19 DME Specific Peptides for PDIA3 (P30101) (see all 19)
     KSEPIPE  GFPTIYF  LVEFFAP  EYDDNGEGI 

    PDIA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005304.3  
    ENSEMBL proteins: 
     ENSP00000300289   ENSP00000391111   ENSP00000398005   ENSP00000389906   ENSP00000438260  
    Reactome Protein details: P30101
    Human Recombinant Protein Products: 
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    Novus Biologicals PDIA3 Lysates
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    ProSpec Recombinant Protein for PDIA3
    Uscn Proteins for PDIA3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0009986cell surface IDA19995400
    GO:0042470melanosome IEA--
    GO:0045335phagocytic vesicle ----


    PDIA3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PDIA3

    Protein Domains /
    Families
    for PDIA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDIA3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold
     IPR005788 Disulphide_isomerase
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS

    Graphical View of Domain Structure for InterPro Entry P30101

    ProtoNet protein and cluster: P30101

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: PDIA3_HUMAN, P30101
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 2 thioredoxin domains


    Function
    for PDIA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDIA3_HUMAN, P30101
    Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins

    Enzyme Number (IUBMB): EC 5.3.4.11 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDIA3
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PDIA3 (see all 23):
    hsa-miR-582-3p hsa-miR-148b hsa-miR-520d-5p hsa-miR-10b* hsa-miR-501-5p hsa-miR-3613-3p hsa-miR-1208 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: PDIA3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDIA3 (see all 7)
    OriGene shRNA RFP: PDIA3
    OriGene siRNA: PDIA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDIA3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDIA3

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDIA3 

    Cell Line
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    Search LifeMap BioReagents cell lines for PDIA3

    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IEA--
    GO:0004197cysteine-type endopeptidase activity TAS9399589
    GO:0004629phospholipase C activity TAS3398923
    GO:0005515protein binding IPI17055437
    GO:0009055electron carrier activity IEA--


    PDIA3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Pdia3tm1.1Gjh for PDIA3
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Pdia3):
     cellular  embryogenesis  growth/size  immune system  mortality/aging 
     skeleton 

    PDIA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDIA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Metabolism of proteins0.15
    		Post-translational protein modification0.44
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Calnexin/calreticulin cycle
    		Calnexin/calreticulin cycle1.00
    		N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.85
    4Immune response Antigen presentation by MHC class I
    		Immune response Antigen presentation by MHC class I1.00
    		Immune response_Antigen presentation by MHC class I0.92
    5Translocation of peptide bound MHC class I complex to cell surface
    		Peptide loading on MHC class I in phagosome0.70
    		Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.28

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for PDIA3
        Immune response Antigen presentation by MHC class I
    Selected targets of GCR-alpha


    1 Cell Signaling Technology (CST) Pathway for PDIA3
        Translational Control

    1 GeneGo (Thomson Reuters) Pathway for PDIA3
        Immune response Antigen presentation by MHC class I

    5/12        Reactome Pathways for PDIA3 (see all 12)
        Peptide loading on MHC class I in phagosome
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Antigen processing-Cross presentation
    Asparagine N-linked glycosylation
    Calnexin/calreticulin cycle


    2         Kegg Pathways  (Kegg details for PDIA3):
        Protein processing in endoplasmic reticulum
    Antigen processing and presentation


    PDIA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDIA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for PDIA3 (P301011, 2, 3 ENSP000003002894) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-AP304433, ENSP000003660054I2D: score=1 I2D: score=1 MINT-4653981 I2D: score=1 STRING: ENSP00000366005
    CALRP277972, 3, ENSP000003208664MINT-16879 MINT-16517 I2D: score=5 STRING: ENSP00000320866
    P4HBP072372, 3, ENSP000003278014MINT-7718424 MINT-4053260 I2D: score=1 STRING: ENSP00000327801
    PRDX4Q131622, 3, ENSP000003686464MINT-8090942 MINT-8090965 I2D: score=1 STRING: ENSP00000368646
    APPP050671, 3, ENSP000002849814EBI-979862,EBI-77613 I2D: score=1 STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0006457protein folding TAS--
    GO:0006606protein import into nucleus TAS7487104
    GO:0006621protein retention in ER lumen TAS9399589


    PDIA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDIA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDIA3 for compounds           About GeneDecksing

    EMD Millipore small molecules for PDIA3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDIA3
    10/15 Novoseek chemical compound relationships for PDIA3 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 64.6 2 14978212 (2)
    cysteine 27.3 2 17459881 (1), 19687800 (1)
    polysaccharide 27 3 9497314 (1), 9637923 (1)
    carnitine 18.1 6 7998951 (2), 7487104 (2)
    inositol 1.18 1 7651180 (1)
    atp 0 2 15892163 (1), 12783457 (1)
    inositol 1,4,5 trisphosphate 0 1 11752607 (1)
    glucose 0 7 8232244 (1), 12239218 (1), 12923326 (1), 14978212 (1) (see all 6)
    calcium 0 12 14699087 (4), 9704062 (1), 9610389 (1), 16291754 (1) (see all 6)
    tyrosine 0 2 15864435 (1), 15886816 (1)

    Search CenterWatch for drugs/clinical trials and news about PDIA3 

    Transcripts
    for PDIA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDIA3 gene: 
    NM_005313.4  

    Unigene Cluster for PDIA3:

    Protein disulfide isomerase family A, member 3
    Hs.591095  [show with all ESTs]
    Unigene Representative Sequence: NM_005313
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300289(uc001zsu.3 uc010bdp.3 uc010ued.2) ENST00000469684
    ENST00000446523 ENST00000434494 ENST00000455250 ENST00000497349 ENST00000538521


    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PDIA3 (see all 23):
    hsa-miR-582-3p hsa-miR-148b hsa-miR-520d-5p hsa-miR-10b* hsa-miR-501-5p hsa-miR-3613-3p hsa-miR-1208 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: PDIA3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK075455.1 AK075481.1 AK293249.1 BC014433.1 BC036000.1 BC071878.1 D16234.1 D83485.1 
    U42068.1 Z49835.1 

    24/62 DOTS entries (see all 62):

    DT.91774848  DT.100658923  DT.100774813  DT.100844394  DT.100657655  DT.100856963  DT.121025163  DT.452142 
    DT.100856961  DT.100856980  DT.100856944  DT.100856962  DT.100856960  DT.121025037  DT.100856973  DT.121024931 
    DT.95362193  DT.100856954  DT.100768670  DT.121025292  DT.121024875  DT.100856957  DT.100856949  DT.95182183 

    24/1011 AceView cDNA sequences (see all 1011):

    BP430107 CB160259 AU108078 CB110006 BF971218 BM799668 CK430218 BM785514 
    BG287393 BM832117 BQ688568 CR614986 CA868581 AA026318 BM763436 BI818781 
    AW352103 BM764035 AI174230 AA453109 AW352086 BU784651 CA943730 BI792330 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PDIA3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
    SP1:                          -                                                                                             
    SP2:                    -     -                                                                                             
    SP3:                    -                                                                                                   
    SP4:                                                                                                                        
    SP5:                    -     -     -                                                                                       


    ECgene alternative splicing isoforms for PDIA3

    Expression
    for PDIA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDIA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGAGGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PDIA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDIA3

    SOURCE GeneReport for Unigene cluster: Hs.591095

    UniProtKB/Swiss-Prot: PDIA3_HUMAN, P30101
    Tissue specificity: Detected in the flagellum and head region of spermatozoa (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including PDIA3: 
              Unfolded Protein Response in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDIA3

    Orthologs
    for PDIA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDIA3 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pdia31 , 5 protein disulfide isomerase associated 31, 5 90.17(n)1
    93.07(a)1    		   2 (60.38 cM)5
    148271  NM_007952.21  NP_031978.21 
     1214137755 
    chicken
    (Gallus gallus)    		 Aves PDIA31 protein disulfide isomerase family A, member 3 76.69(n)
    82.16(a)    		   373899  NM_204110.3  NP_989441.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDIA36
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343759.1(215951-226805)
    African clawed frog
    (Xenopus laevis)    		 Amphibia grp58-prov2 glucose regulated protein, 58kDa 75.13(n)    BC046707.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.65012 Danio rerio, clone IMAGE3818635, mRNA, partial cds 77.32(n)    BC044524.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ERp601 CG8983-PA 53.28(n)
    49.68(a)    		   36270  NM_165849.2  NP_725084.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea pdi-31 Protein PDI-3 55.25(n)
    48.41(a)    		   172433  NM_059594.5  NP_491995.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATPDI56
    PDI66
    		 protein disulfide-isomerase 2
    		 34(a)
    33(a)
    		 many ↔ many
    many ↔ many
    		 1(7645700-7648841)
    1(29126650-29129612)
    rice
    (Oryza sativa)    		 Liliopsida Os02g05549001 hypothetical protein 47.9(n)
    38.96(a)    		   4329652  NM_001053654.1  NP_001047119.1 


    ENSEMBL Gene Tree for PDIA3 (if available)
    TreeFam Gene Tree for PDIA3 (if available) 

    Paralogs
    for PDIA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDIA3 gene
    PDIA62  PDIA22  PDIA52  PDIA42  TMX32  ERP272  DNAJC102  P4HB2  
    TXNDC52  PDILT2  
    9 SIMAP similar genes for PDIA3 using alignment to 6 protein entries:     PDIA3_HUMAN (see all proteins):
    PDIA4    PDIA6    TMX3    TXN    PDIA5    P4HB
    PDIA2    DNAJC10    QSOX1

    PDIA3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PDIA3
    PGOHUM00000247100 PGOHUM00000244962 PGOHUM00000263284


    Genomic Variants
    for PDIA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in PDIA3 are shown (see all 474)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1421198231,2
    		--44036695(+) TATACA/GTTGAG 2 -- nc-transcript-variantus2k10--------
    rs1170913291,2
    		C,F,--44036768(+) GGATCT/AACAAC 2 -- spa1 us2k12Minor allele frequency- A:0.02NA EU 713
    rs129012731,2
    		--44036781(+) AAATTA/GAAAAG 2 -- us2k1 int10--------
    rs1462271101,2
    		--44036785(+) TGAAAA/GGGGGT 2 -- us2k1 int10--------
    rs129012771,2
    		A,--44036789(+) AAGGGA/GTAGTG 2 -- int1 us2k10--------
    rs1484265211,2
    		--44036824(+) GGTAGG/TGTTGG 2 -- int1 us2k10--------
    rs1850833251,2
    		--44036832(+) TGGGGA/GCAGGG 2 -- int1 us2k10--------
    rs129022501,2
    		--44036844(+) TACTGG/TTCAGA 2 -- int1 us2k10--------
    rs129010261,2
    		H,--44036849(+) TTCAGA/GTAATG 2 -- us2k1 int14Minor allele frequency- G:0.00NS EA 418
    rs129011651,2
    		--44036858(+) TGGGTC/TCCCCT 2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for PDIA3 (44038590 - 44065477 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PDIA3
         4 CNVs: 3079 87664 7062 3960

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PDIA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDIA3 for disorders           About GeneDecksing

    OMIM gene information: 602046    OMIM disorders: --

    20/34 diseases for PDIA3 (see all 34):    About MalaCards
    von willebrand's disease    esophageal squamous cell carcinoma    squamous cell carcinoma    pancreatic ductal carcinoma
    epithelial ovarian cancer    autoimmune hepatitis    ovarian cancer    gastric cancer
    endocarditis    epididymitis    insulinoma    esophagitis
    carcinoma    prostate cancer    lung adenocarcinoma    colon carcinoma
    pertussis    hepatocellular carcinoma    esophageal cancer    cervical cancer

    7 Novoseek disease relationships for PDIA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia basophilic 34.2 1 7487104 (1)
    shock 19 7 12923326 (1), 18316623 (1), 19372559 (1), 17868153 (1) (see all 7)
    melanoma 8.94 2 19995546 (2)
    tumors 2.78 8 18684944 (3), 16534743 (1), 10545276 (1), 14522930 (1) (see all 5)
    gastric cancer 0 1 12923326 (1)
    prostate cancer 0 1 18751977 (1)
    cancer 0 1 17353921 (1)

    Human Genome Epidemiology (HuGE) Navigator: PDIA3 (1 document)

    Export disorders for PDIA3 gene to outside databases

    Publications
    for PDIA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDIA3 gene, integrated from 9 sources (see all 273):
    (articles sorted by number of sources associating them with PDIA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures of the human gene for the protein disulfide isomerase- related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21. (PubMed id 9205111)1, 2, 9 Koivunen P.... Kivirikko K.I. (1997)
    2. cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase. (PubMed id 7487104)1, 2, 9 Bourdi M.... Pohl L.R. (1995)
    3. Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha). (PubMed id 8624847)1, 2, 9 Charnock-Jones D.S.... Smith S.K. (1996)
    4. Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. (PubMed id 19119025)1, 2 Dong G.... Reinisch K.M. (2009)
    5. ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57. (PubMed id 16940051)1, 2 Alanen H.I....Ruddock L.W. (2006)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
    10. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)

    External Searches for PDIA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDIA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2923 HGNC: 4606 AceView: GRP58 Ensembl:ENSG00000167004 euGenes: HUgn2923
    ECgene: PDIA3 Kegg: 2923 H-InvDB: PDIA3

    Other Databases showing PDIA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDIA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDIA3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PDIA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDIA3 gene:
    Search GeneIP for patents involving PDIA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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