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Aliases for PDIA3 Gene

Aliases for PDIA3 Gene

  • Protein Disulfide Isomerase Family A Member 3 2 3 5
  • Protein Disulfide Isomerase Family A, Member 3 2 3
  • Endoplasmic Reticulum Resident Protein 60 3 4
  • Endoplasmic Reticulum Resident Protein 57 3 4
  • Protein Disulfide Isomerase-Associated 3 2 3
  • Glucose Regulated Protein, 58kDa 2 3
  • 58 KDa Glucose-Regulated Protein 3 4
  • Disulfide Isomerase ER-60 3 4
  • 58 KDa Microsomal Protein 3 4
  • ER Protein 57 3 4
  • ER Protein 60 3 4
  • EC 4 63
  • ERp60 3 4
  • GRP58 3 4
  • ERp57 3 4
  • P58 3 4
  • Epididymis Secretory Sperm Binding Protein Li 93n 3
  • Epididymis Secretory Protein Li 269 3
  • Endoplasmic Reticulum P58 3
  • Phospholipase C-Alpha 3
  • HEL-S-269 3
  • HEL-S-93n 3
  • HsT17083 3
  • PI-PLC 3
  • ERp61 3
  • GRP57 3
  • ER60 3

External Ids for PDIA3 Gene

Previous HGNC Symbols for PDIA3 Gene

  • GRP58

Previous GeneCards Identifiers for PDIA3 Gene

  • GC15P041826
  • GC15P044038
  • GC15P020861

Summaries for PDIA3 Gene

Entrez Gene Summary for PDIA3 Gene

  • This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDIA3 Gene

PDIA3 (Protein Disulfide Isomerase Family A Member 3) is a Protein Coding gene. Diseases associated with PDIA3 include Maxillary Sinus Cancer and Paranasal Sinus Cancer. Among its related pathways are Protein processing in endoplasmic reticulum and Antigen Presentation- Folding, assembly and peptide loading of class I MHC. GO annotations related to this gene include poly(A) RNA binding and protein disulfide oxidoreductase activity. An important paralog of this gene is PDIA4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDIA3 Gene

Genomics for PDIA3 Gene

Regulatory Elements for PDIA3 Gene

Enhancers for PDIA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDIA3 on UCSC Golden Path with GeneCards custom track

Promoters for PDIA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDIA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDIA3 Gene

43,746,392 bp from pter
43,773,279 bp from pter
26,888 bases
Plus strand

Genomic View for PDIA3 Gene

Genes around PDIA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDIA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDIA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDIA3 Gene

Proteins for PDIA3 Gene

  • Protein details for PDIA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein disulfide-isomerase A3
    Protein Accession:
    Secondary Accessions:
    • Q13453
    • Q14255
    • Q8IYF8
    • Q9UMU7

    Protein attributes for PDIA3 Gene

    505 amino acids
    Molecular mass:
    56782 Da
    Quaternary structure:
    • Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with the S and Z variants of SERPINA1. Interacts with ATP2A2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PDIA3 Gene

neXtProt entry for PDIA3 Gene

Proteomics data for PDIA3 Gene at MOPED

Post-translational modifications for PDIA3 Gene

  • Ubiquitination at Lys 94, Lys 104, Lys 296, Lys 305, Lys 335, and Lys 362
  • Glycosylation at Thr 102, Thr 452, and Thr 485
  • Modification sites at PhosphoSitePlus

Other Protein References for PDIA3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDIA3 (GRP58)

Domains & Families for PDIA3 Gene

Gene Families for PDIA3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
  • Contains 2 thioredoxin domains.
  • Belongs to the protein disulfide isomerase family.
genes like me logo Genes that share domains with PDIA3: view

Function for PDIA3 Gene

Molecular function for PDIA3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Catalyzes the rearrangement of -S-S- bonds in proteins.

Enzyme Numbers (IUBMB) for PDIA3 Gene

Gene Ontology (GO) - Molecular Function for PDIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015035 protein disulfide oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PDIA3: view
genes like me logo Genes that share phenotypes with PDIA3: view

Animal Models for PDIA3 Gene

MGI Knock Outs for PDIA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PDIA3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDIA3 Gene

Localization for PDIA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDIA3 Gene

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269 PubMed:12643545}.

Subcellular locations from

Jensen Localization Image for PDIA3 Gene COMPARTMENTS Subcellular localization image for PDIA3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 2
plasma membrane 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PDIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PDIA3: view

Pathways & Interactions for PDIA3 Gene

genes like me logo Genes that share pathways with PDIA3: view

Gene Ontology (GO) - Biological Process for PDIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006606 protein import into nucleus TAS 7487104
GO:0006621 protein retention in ER lumen TAS 9399589
GO:0006662 glycerol ether metabolic process IEA --
GO:0034975 protein folding in endoplasmic reticulum TAS 22013210
genes like me logo Genes that share ontologies with PDIA3: view

No data available for SIGNOR curated interactions for PDIA3 Gene

Drugs & Compounds for PDIA3 Gene

(8) Drugs for PDIA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for PDIA3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PDIA3: view

Transcripts for PDIA3 Gene

Unigene Clusters for PDIA3 Gene

Protein disulfide isomerase family A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDIA3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: -
SP2: - -
SP3: -
SP5: - - -

Relevant External Links for PDIA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDIA3 Gene

mRNA expression in normal human tissues for PDIA3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDIA3 Gene

SOURCE GeneReport for Unigene cluster for PDIA3 Gene Hs.591095

mRNA Expression by UniProt/SwissProt for PDIA3 Gene

Tissue specificity: Detected in the flagellum and head region of spermatozoa (at protein level).
genes like me logo Genes that share expression patterns with PDIA3: view

Protein tissue co-expression partners for PDIA3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PDIA3 Gene

Orthologs for PDIA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDIA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDIA3 35
  • 92.61 (n)
  • 95.25 (a)
PDIA3 36
  • 95 (a)
(Canis familiaris)
Mammalia PDIA3 35
  • 92.52 (n)
  • 95.71 (a)
-- 36
  • 85 (a)
-- 36
  • 96 (a)
(Mus musculus)
Mammalia Pdia3 35
  • 90.17 (n)
  • 93.07 (a)
Pdia3 16
Pdia3 36
  • 93 (a)
(Pan troglodytes)
Mammalia PDIA3 35
  • 99.74 (n)
  • 100 (a)
PDIA3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pdia3 35
  • 89.57 (n)
  • 92.08 (a)
(Monodelphis domestica)
Mammalia PDIA3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia PDIA3 36
  • 90 (a)
(Gallus gallus)
Aves PDIA3 35
  • 77.52 (n)
  • 83.51 (a)
PDIA3 36
  • 81 (a)
(Anolis carolinensis)
Reptilia PDIA3 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75624 35
pdia3 35
  • 73.85 (n)
  • 77.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia grp58-prov 35
(Danio rerio)
Actinopterygii Dr.6501 35
pdia3 35
  • 72.46 (n)
  • 78.11 (a)
pdia3 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007393 35
  • 53.91 (n)
  • 49.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta ERp60 35
  • 53.86 (n)
  • 51.24 (a)
ERp60 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea pdi-3 35
  • 55.93 (n)
  • 49.1 (a)
pdi-3 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EUG1 36
  • 25 (a)
PDI1 36
  • 28 (a)
EUG1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.651 35
(Oryza sativa)
Liliopsida Os04g0436300 35
  • 49.42 (n)
  • 38.98 (a)
(Triticum aestivum)
Liliopsida Ta.796 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7969 36
  • 46 (a)
Species with no ortholog for PDIA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PDIA3 Gene

Gene Tree for PDIA3 (if available)
Gene Tree for PDIA3 (if available)

Paralogs for PDIA3 Gene

Paralogs for PDIA3 Gene

(9) SIMAP similar genes for PDIA3 Gene using alignment to 6 proteins: Pseudogenes for PDIA3 Gene

genes like me logo Genes that share paralogs with PDIA3: view

Variants for PDIA3 Gene

Sequence variations from dbSNP and Humsavar for PDIA3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs6413485 - 43,769,624(+) GCCCA(A/G)GTATA reference, missense
rs4924721 -- 43,756,033(+) ATCTT(A/G)TGGAG intron-variant
rs4924722 -- 43,764,537(+) ATCTC(A/G)GCTCA intron-variant
rs12101756 -- 43,761,689(+) GTACT(A/G)TATAG intron-variant
rs12438668 -- 43,750,706(+) ggagg(C/T)ggagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDIA3 Gene

Variant ID Type Subtype PubMed ID
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850
dgv2372n71 CNV Gain 21882294
dgv743e1 CNV Complex 17122850
esv33661 CNV Loss 17666407

Variation tolerance for PDIA3 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDIA3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDIA3 Gene

Disorders for PDIA3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDIA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
maxillary sinus cancer
  • malignant neoplasm of antrum
paranasal sinus cancer
  • adenoid cystic carcinoma of accessory sinus
- elite association - COSMIC cancer census association via MalaCards
Search PDIA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDIA3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PDIA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDIA3 Gene

Publications for PDIA3 Gene

  1. Structures of the human gene for the protein disulfide isomerase- related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21. (PMID: 9205111) Koivunen P. … Kivirikko K.I. (Genomics 1997) 3 4 23 67
  2. Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line. (PMID: 19995546) Chichiarelli S. … Eufemi M. (Arch. Biochem. Biophys. 2010) 3 23
  3. Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor. (PMID: 20029959) Ayala YA!A+ez R. … Conn P.M. (Cell Biochem. Funct. 2010) 3 23
  4. Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. (PMID: 19411306) Xu D. … Truog W.E. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  5. Functional significance of tapasin membrane association and disulfide linkage to ERp57 in MHC class I presentation. (PMID: 19701894) Vigneron N. … Cresswell P. (Eur. J. Immunol. 2009) 3 23

Products for PDIA3 Gene

Sources for PDIA3 Gene