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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDIA2 Gene

protein-coding   GIFtS: 58
GCID: GC16P000336

Protein Disulfide Isomerase Family A, Member 2

(Previous names: protein disulfide isomerase, pancreatic, protein disulfide...)
(Previous symbol: PDIP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Disulfide Isomerase Family A, Member 21 2     PDI2
PDIP1 2 3 5     PDIR2
Protein Disulfide Isomerase, Pancreatic1 2     Pancreatic Protein Disulfide Isomerase2
Protein Disulfide Isomerase-Associated 21 2     Protein Disulfide Isomerase A22
Pancreas-Specific Protein Disulfide Isomerase2 3     Protein Disulfide-Isomerase A22
EC 5.3.4.13 8     Rho GDP Dissociation Inhibitor Gamma2
PDA22     PDIp3

External Ids:    HGNC: 141801   Entrez Gene: 647142   Ensembl: ENSG000001856157   OMIM: 6080125   UniProtKB: Q130873   

Export aliases for PDIA2 gene to outside databases

Previous GC identifers: GC16P000274 GC16P000276 GC16P000334 GC16P000251


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDIA2 Gene:
Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that
catalyze protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 (PubMed
8561901)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PDIA2 Gene: 
PDIA2 (protein disulfide isomerase family A, member 2) is a protein-coding gene. Diseases associated with PDIA2 include diphtheria, and brain ischemia, and among its related super-pathways are Statin Pathway, Pharmacodynamics. GO annotations related to this gene include electron carrier activity and steroid binding. An important paralog of this gene is PDIA4.

UniProtKB/Swiss-Prot: PDIA2_HUMAN, Q13087
Function: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and
biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded
proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDIA2 gene promoter:
         Lmo2   AP-2gamma   Evi-1   COMP1   AP-2beta   NF-Y   AP-2alpha   AP-2alphaA   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDIA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDIA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDIA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PDIA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDIA2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000336:  view genomic region     (about GC identifiers)

Start:
333,118 bp from pter      End:
337,215 bp from pter
Size:
4,098 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDIA2_HUMAN, Q13087 (See protein sequence)
Recommended Name: Protein disulfide-isomerase A2 precursor  
Size: 525 amino acids; 58206 Da
Subunit: Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large
chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1,
UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX
Subcellular location: Endoplasmic reticulum lumen (By similarity)
Sequence caution: Sequence=AAC50401.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=AAH75029.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Sequence of unknown origin in the N-terminal part; Sequence=BAG58339.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A6ZJ64 B4DI27 Q2WGM4 Q4TT67 Q6B010 Q96KJ6 Q9BW95
Alternative splicing: 2 isoforms:  Q13087-1   Q13087-2   

Explore the universe of human proteins at neXtProt for PDIA2: NX_Q13087

Explore proteomics data for PDIA2 at MOPED 

Post-translational modifications:

  • UniProtKB: The disulfide-linked homodimer exhibits an enhanced chaperone activity
  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13087

  • 2 DME Specific Peptides for PDIA2 (Q13087)
     LVGKNFE  VVLFKKFDEGR 

    PDIA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDIA2 Protein Expression
    REFSEQ proteins: NP_006840.2  
    ENSEMBL proteins: 
     ENSP00000219406   ENSP00000384410   ENSP00000392277   ENSP00000405081  

    Human Recombinant Protein Products for PDIA2: 
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    Cloud-Clone Corp. Proteins for PDIA2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12095988
    GO:0005788endoplasmic reticulum lumen IEA--

    PDIA2 for ontologies           About GeneDecksing



    PDIA2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDI: Protein disulfide isomerases

    5 InterPro protein domains:
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS
     IPR005792 Prot_disulphide_isomerase

    Graphical View of Domain Structure for InterPro Entry Q13087

    ProtoNet protein and cluster: Q13087

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: PDIA2_HUMAN, Q13087
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 2 thioredoxin domains


    PDIA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDIA2_HUMAN, Q13087
    Function: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and
    biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded
    proteins
    Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins

         Enzyme Number (IUBMB): EC 5.3.4.11 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IEA--
    GO:0005496steroid binding IEA--
    GO:0005515protein binding IPI12095988
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
         
    PDIA2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDIA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Statin Pathway, Pharmacodynamics
    Statin Pathway0.73


    1 BioSystems Pathway for PDIA2
        Statin Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDIA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for PDIA2 (Q130871, 2, 3 ENSP000002194064) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALRP277972, 3, ENSP000003208664MINT-8401737 I2D: score=2 STRING: ENSP00000320866
    NCK1P163331, 3, ENSP000002889864EBI-1752525,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8561901
    GO:0006621protein retention in ER lumen TAS8561901
    GO:0006662glycerol ether metabolic process IEA--
    GO:0034976response to endoplasmic reticulum stress IMP12095988
    GO:0045454cell redox homeostasis IEA--

    PDIA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDIA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDIA2

    10/18 Novoseek inferred chemical compound relationships for PDIA2 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dtnb 59.9 3 10912786 (1), 19564574 (1)
    cystamine 59.9 8 18618447 (4), 7516709 (2)
    gssg 57.1 18 1988050 (5), 8307992 (2), 1988051 (2), 8688495 (1) (see all 6)
    dithiol 54.9 3 1988050 (1), 10734129 (1)
    cysteine 43.8 16 7516709 (3), 8307992 (3), 14871477 (2), 8902616 (2) (see all 8)
    dithiothreitol 30.3 4 11968009 (3)
    nadph 19.8 11 19564574 (5), 19925454 (1), 19388824 (1), 15081871 (1)
    h2o2 13.9 2 11795901 (1)
    fibrinogen 9.56 1 11352743 (1)
    sulfur 8.51 4 10734129 (2), 8307992 (1)

    Search CenterWatch for drugs/clinical trials and news about PDIA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDIA2 gene: 
    NM_006849.2  

    Unigene Cluster for PDIA2:

    Protein disulfide isomerase family A, member 2
    Hs.66581  [show with all ESTs]
    Unigene Representative Sequence: NM_006849
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219406(uc002cgn.1 uc002cgo.1) ENST00000467212(uc010bqt.1)
    ENST00000404312 ENST00000456379 ENST00000482665 ENST00000462950 ENST00000435833

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK075485.1 AK295383.1 AK308516.1 BC000537.2 BC027964.1 BC075029.2 U19948.1 

    6 DOTS entries:

    DT.105057  DT.101978822  DT.120711847  DT.100017093  DT.99949763  DT.120711886 

    24/60 AceView cDNA sequences (see all 60):

    AK124931 AF498928 BC000537 AI369830 NM_001176 CB152764 AI041729 CB152066 
    BM691552 BC027964 AW135368 AK075485 BX643613 AA324789 BI838005 BV198796 
    BX110662 U19948 BI195517 CB565893 BM709619 AA323150 H21176 BI834460 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PDIA2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                          -                                                   
    SP2:        -                                                                                                                     
    SP3:        -                 -                                                                                                   
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PDIA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDIA2 expression in normal human tissues (normalized intensities)      PDIA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCCTCAA
    PDIA2 Expression
    About this image


    PDIA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 4 entries
             small intestine ; glandular cells   
             neonatal small intestine   
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Duct Cells Pancreatic Ducts
             pancreas ; exocrine glandular cells   
             Pancreatic Islet   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 3 entries
             stomach, upper ; glandular cells   
             stomach cardiac   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             cerebellum   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See PDIA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDIA2

    SOURCE GeneReport for Unigene cluster: Hs.66581

    UniProtKB/Swiss-Prot: PDIA2_HUMAN, Q13087
    Tissue specificity: Highly expressed in pancreas (at protein level)

        SABiosciences Custom PCR Arrays for PDIA2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDIA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDIA2 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdia21 , 5 protein disulfide isomerase associated 21, 5 79.73(n)1
    78.97(a)1
      17 (13.07 cM)5
    691911  NM_001081070.11  NP_001074539.11 
     261959995 
    chicken
    (Gallus gallus)
    Aves LOC1008578971 protein disulfide-isomerase A2-like 65.98(n)
    56.17(a)
      100857897  XM_003642154.1  XP_003642202.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDIA26
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL344563.1(23219-26733)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.88232 Transcribed sequence with weak similarity to protein prf2206317A (H.sapiens) 2206317A protein SS isomerase [Homo sapiens] less 72.39(n)    CF591301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045330.12   -- 78.11(n)   394023  BC045330.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PDI16
    EUG16
    Protein disulfide isomerase; multifunctional prote...
    Protein disulfide isomerase of the endoplasmic ret...
    24(a)
    23(a)
    many ↔ many
    many ↔ many
    III(48653-50221)
    IV(1478608-1480161)


    ENSEMBL Gene Tree for PDIA2 (if available)
    TreeFam Gene Tree for PDIA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDIA2 gene
    PDIA42  ERP272  TMX32  P4HB2  PDIA32  PDILT2  
    5 SIMAP similar genes for PDIA2 using alignment to 5 protein entries:     PDIA2_HUMAN (see all proteins):
    P4HB    PDIA3    PDILT    ERP27    PDIA6

    PDIA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 SNPs in PDIA2 are shown (see all 287)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0480874
    ----see VAR_0480872 P S mis40--------
    rs1807196931,2
    --333508(+) CCCAGG/TAGCTC 1 -- int10--------
    rs1845647111,2
    --333604(+) TGCCTC/TCCTGC 1 -- int10--------
    rs788369591,2
    C,F--333612(+) TGCTCG/AGCCAG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1446035881,2
    --333625(+) GCCACA/GGTGCC 1 -- int10--------
    rs1478846031,2
    --333626(+) CCACGA/GTGCCA 1 -- int10--------
    rs454529911,2
    C,F--333697(+) GGCTCG/AGGCAG 1 -- int14Minor allele frequency- A:0.05NS WA 210
    rs1415660351,2
    --333725(+) CCCATA/GGAGGT 1 -- int10--------
    rs1149262671,2
    C,F--333760(+) TTTTCA/G/TCAACC 1 -- int11WA 118
    rs772236821,2
    C,F--333842(+) CCATAC/AAAGGC 1 -- int11Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for PDIA2 (333118 - 337215 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for PDIA2 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904690CNV Loss21882294
    nsv904674CNV Loss21882294
    dgv2465n71CNV Loss21882294
    dgv2471n71CNV Loss21882294
    dgv2470n71CNV Loss21882294
    nsv904677CNV Loss21882294
    dgv2458n71CNV Loss21882294
    dgv2469n71CNV Loss21882294
    dgv32n68CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608012    OMIM disorders: --

    14 diseases for PDIA2:    About MalaCards
    diphtheria    brain ischemia    ischemia    protein s deficiency
    pancreatitis    hypoxia    cholera    hyperglycemia
    alzheimer's disease    insulin resistance    parkinson's disease    endotheliitis
    adenocarcinoma    neuronitis


    PDIA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for PDIA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoxia ischemia brain 69.4 1 15147878 (1)
    neurodegeneration 17.5 2 15353226 (1)
    neurodegenerative diseases 15.9 4 16724068 (2), 12453628 (1)
    diphtheria 13.3 1 9020187 (1)
    immunodeficiency 7.07 2 11181151 (1)
    tumors 1.7 1 8561901 (1)
    ischemia 0 8 15670653 (3), 10744727 (1)
    shock 0 1 15952740 (1)
    hiv infections 0 1 17301129 (1)
    alzheimers disease 0 2 12453628 (1), 16724068 (1)

    Genetic Association Database (GAD): PDIA2
    Human Genome Epidemiology (HuGE) Navigator: PDIA2 (4 documents)

    Export disorders for PDIA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDIA2 gene, integrated from 9 sources (see all 200):
    (articles sorted by number of sources associating them with PDIA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal localization of a new protein disulfide isomerase, PDIp, highly expressed in human pancreas. (PubMed id 8561901)1, 2, 3, 9 Desilva M.G....Lan M.S. (1996)
    2. Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells. (PubMed id 19429457)1, 2, 9 Fu X.M. and Zhu B.T. (2009)
    3. Human pancreas-specific protein disulfide isomerase homolog (PDIp) is redox-regulated through formation of an inter-subunit disulfide bond. (PubMed id 19150607)1, 2, 9 Fu X. and Zhu B.T. (2009)
    4. N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2). (PubMed id 23167757)1, 2 Walker A.K.... Atkin J.D. (2013)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Application of gene network analysis techniques ident ifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve . (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    9. Molecular characterization of a pancreas-specific protein disulfide isomerase, PDIp. (PubMed id 9115635)2, 9 Desilva M.G.... Lan M.S. (1997)
    10. Pancreas-specific protein disulfide isomerase has a c ell type-specific expression in various mouse tissues and is absent in human pa ncreatic adenocarcinoma cells: implications for its functions. (PubMed id 19821078)1, 9 Fu X.M....Zhu B.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64714 HGNC: 14180 AceView: ARHGDIG Ensembl:ENSG00000185615 euGenes: HUgn64714
    ECgene: PDIA2 H-InvDB: PDIA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDIA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDIA2 gene:
    Search GeneIP for patents involving PDIA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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