Aliases for PDIA2 Gene
External Ids for PDIA2 Gene
Previous HGNC Symbols for PDIA2 Gene
Previous GeneCards Identifiers for PDIA2 Gene
Protein disulfide isomerases (EC 18.104.22.168), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 [PubMed 8561901]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PDIA2 Gene
PDIA2 (Protein Disulfide Isomerase Family A, Member 2) is a Protein Coding gene. Diseases associated with PDIA2 include multiple sulfatase deficiency. Among its related pathways are Statin Pathway. GO annotations related to this gene include electron carrier activity and steroid binding. An important paralog of this gene is PDIA3.
UniProtKB/Swiss-Prot for PDIA2 Gene
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.