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PDHX Gene

protein-coding   GIFtS: 67
GCID: GC11P034894

Pyruvate Dehydrogenase Complex, Component X

  See PDHX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pyruvate Dehydrogenase Complex, Component X1 2     DLDBP2
PDX12 3 5     OPDX2
Dihydrolipoamide Dehydrogenase-Binding Protein Of Pyruvate Dehydrogenase
Complex2 3
     Pyruvate Dehydrogenase Complex, E3-Binding Protein Subunit2
Lipoyl-Containing Pyruvate Dehydrogenase Complex Component X2 3     Pyruvate Dehydrogenase Complex, Lipoyl-Containing Component X2
E3BP2 3     Pyruvate Dehydrogenase Protein X Component, Mitochondrial2
proX2 3     E3-Binding Protein3

External Ids:    HGNC: 213501   Entrez Gene: 80502   Ensembl: ENSG000001104357   OMIM: 6087695   UniProtKB: O003303   

Export aliases for PDHX gene to outside databases

Previous GC identifers: GC11P034977 GC11P034902 GC11P034636


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDHX Gene:
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of
pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains
three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a
non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as
component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH
complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological
dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for
antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune
liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial
cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to
cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct
isoforms.(provided by RefSeq, Oct 2009)

GeneCards Summary for PDHX Gene:
PDHX (pyruvate dehydrogenase complex, component X) is a protein-coding gene. Diseases associated with PDHX include pyruvate dehydrogenase e3-binding protein deficiency, and lacticacidemia due to pdx1 deficiency. GO annotations related to this gene include transferase activity, transferring acyl groups.

UniProtKB/Swiss-Prot: ODPX_HUMAN, O00330
Function: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2)
core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional
PDH complex

Gene Wiki entry for PDHX (E3 binding protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDHX gene promoter:
         ER-alpha   GATA-3   Brachyury   CUTL1   GATA-1   GATA-2   RORalpha1   AREB6   IRF-2   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDHX promoter sequence
   Search Chromatin IP Primers for PDHX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDHX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

PDHX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDHX gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034894:  view genomic region     (about GC identifiers)

Start:
34,937,376 bp from pter      End:
35,042,138 bp from pter
Size:
104,763 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ODPX_HUMAN, O00330 (See protein sequence)
Recommended Name: Pyruvate dehydrogenase protein X component, mitochondrial precursor  
Size: 501 amino acids; 54122 Da
Subunit: Part of the inner core of the multimeric pyruvate dehydrogenase complex that is composed of about 48 DLAT
and 12 PDHX molecules. This core binds multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide
acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3)
4 PDB 3D structures from and Proteopedia for PDHX:
1ZY8 (3D)        2DNC (3D)        2F5Z (3D)        2F60 (3D)    
Secondary accessions: B4DW62 D3DR11 E9PB14 E9PBP7 O60221 Q96FV8 Q99783
Alternative splicing: 3 isoforms:  O00330-1   O00330-2   O00330-3   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for PDHX: NX_O00330

Explore proteomics data for PDHX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PDHX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128496.1  NP_001159630.1  NP_003468.2  

    ENSEMBL proteins: 
     ENSP00000431281   ENSP00000389404   ENSP00000227868   ENSP00000415695   ENSP00000432277  
     ENSP00000433204  
    Reactome Protein details: O00330

    PDHX Human Recombinant Protein Products:

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    Novus Biologicals PDHX Protein
    Novus Biologicals PDHX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDHX

     
    Search eBioscience for Proteins for PDHX 

    PDHX Antibody Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDHX
    Cloud-Clone Corp. CLIAs for PDHX
    Search eBioscience for ELISAs for PDHX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR004167 E3-bd
     IPR000089 Biotin_lipoyl
     IPR003016 2-oxoA_DH_lipoyl-BS
     IPR001078 2-oxoacid_DH_actylTfrase
     IPR023213 CAT-like_dom

    Graphical View of Domain Structure for InterPro Entry O00330

    ProtoNet protein and cluster: O00330

    4 Blocks protein domains:
    IPB000089 Biotin/lipoyl attachment
    IPB001078 Catalytic domain of components of various dehydrogenase complexes
    IPB003016 2-oxo acid dehydrogenase
    IPB004167 E3 binding domain


    UniProtKB/Swiss-Prot: ODPX_HUMAN, O00330
    Similarity: Belongs to the 2-oxoacid dehydrogenase family
    Similarity: Contains 1 lipoyl-binding domain


    Find genes that share domains with PDHX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ODPX_HUMAN, O00330
    Function: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2)
    core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional
    PDH complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016746transferase activity, transferring acyl groups IEA--
         
    Find genes that share ontologies with PDHX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDHX:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDHX
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDHX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDHX

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDHX:
    hsa-let-7b-5p (MIRT032478), hsa-mir-16-5p (MIRT032040), hsa-mir-181b-5p (MIRT047246), hsa-mir-320a (MIRT044791), hsa-mir-15a-5p (MIRT051324), hsa-mir-193b-3p (MIRT041546), hsa-mir-181d-5p (MIRT041176), hsa-mir-26b-5p (MIRT030260), hsa-mir-29c-3p (MIRT020386)

    Block miRNA regulation of human, mouse, rat PDHX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDHX (see all 19):
    hsa-miR-513a-5p hsa-miR-128 hsa-miR-29a hsa-miR-29c hsa-miR-1297 hsa-miR-3119 hsa-miR-26b hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidPDHX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDHX
    Predesigned siRNA for gene silencing in human, mouse, rat PDHX

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): PDHX (NM_003477)
    Sino Biological Human cDNA Clone for PDHX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDHX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDHX

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PDHX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDHX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ODPX_HUMAN, O00330: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with PDHX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDHX About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Citric acid cycle (TCA cycle)
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    Pyruvate metabolism0.00
    Regulation of pyruvate dehydrogenase (PDH) complex0.00
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    4Glycolysis and gluconeogenesis short map
    Glycolysis and Gluconeogenesis0.60


    Find genes that share SuperPaths with PDHX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PDHX
        Glycolysis and Gluconeogenesis


    2 Reactome Pathways for PDHX
        Pyruvate metabolism
    Regulation of pyruvate dehydrogenase (PDH) complex


    1 Kegg Pathway  (Kegg details for PDHX):
        Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDHX: 
              Homeobox (HOX) Genes in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PDHX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDHX (O003302, 3 ENSP000002278684) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLATP105153, ENSP000002803464I2D: score=3 STRING: ENSP00000280346
    PDHBP111773, ENSP000003072414I2D: score=3 STRING: ENSP00000307241
    DLDP096223, ENSP000002054024I2D: score=3 STRING: ENSP00000205402
    PDK2Q151193, ENSP000000077084I2D: score=3 STRING: ENSP00000007708
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with PDHX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDHX (ODPX)

    1 HMDB Compound for PDHX    About this table
    CompoundSynonyms CAS #PubMed Ids
    Lipoic acid(+)-alpha-Lipoate (see all 92)1077-28-7--

    7 Novoseek inferred chemical compound relationships for PDHX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrolipoamide 86.3 14 16442803 (2), 10094940 (2), 9242632 (2), 10448433 (1) (see all 6)
    pyruvate 78 35 9242632 (3), 16442803 (2), 16843025 (2), 15303005 (2) (see all 20)
    2-oxo acid 77 5 10385636 (1), 10094940 (1)
    alpha lipoic acid 57.3 4 10094940 (1)
    alpha-ketoglutarate 44.8 3 10385636 (1), 10094940 (1)
    glucose 25.4 13 19833727 (4), 16505238 (1)
    serine 0 1 9242632 (1)



    Find genes that share compounds with PDHX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDHX gene (3 alternative transcripts): 
    NM_001135024.1  NM_001166158.1  NM_003477.2  

    Unigene Cluster for PDHX:

    Pyruvate dehydrogenase complex, component X
    Hs.502315  [show with all ESTs]
    Unigene Representative Sequence: NM_003477
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533550 ENST00000448838(uc001mvt.3 uc010rep.2 uc010req.2)
    ENST00000227868 ENST00000430469 ENST00000533262 ENST00000526309 ENST00000532159
    ENST00000477173
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PDHX (see all 19):
    hsa-miR-513a-5p hsa-miR-128 hsa-miR-29a hsa-miR-29c hsa-miR-1297 hsa-miR-3119 hsa-miR-26b hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidPDHX 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): PDHX (NM_003477)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PDHX
      QuantiFast Probe-based Assays in human, mouse, rat PDHX

    Additional mRNA sequence: 

    AF001437.1 AF052166.1 AK057123.1 AK301384.1 AK312463.1 AY952887.1 BC010389.1 BX648910.1 
    U79296.1 U82328.1 Y13145.1 

    16 DOTS entries:

    DT.100730804  DT.456268  DT.86855014  DT.100796281  DT.91862608  DT.453541  DT.92434573  DT.100796288 
    DT.102831508  DT.120698125  DT.100796282  DT.120698132  DT.121036500  DT.100796286  DT.40312513  DT.91983808 

    Selected AceView cDNA sequences (see all 211):

    N48320 H22213 AU125458 BX119658 CR597392 AI051425 F13285 AL119824 
    AL709150 U79296 BM789687 BQ637877 AA724417 BG392023 CB243701 BG547083 
    BF351659 CB133933 BQ024032 CB145699 F10884 BM750869 BF111496 BM802804 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PDHX    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                                        -                 -     -                           
    SP2:                          -     -     -     -     -     -     -           -     -                           
    SP3:                                                        -                 -                                 
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for PDHX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PDHX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAAAAGA
    PDHX Expression
    About this image


    PDHX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PDHX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDHX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502315
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDHX: 
              Homeobox (HOX) Genes in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDHX
    OriGene qSTAR qPCR primer pairs in human, mouse for PDHX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDHX
    QuantiTect SYBR Green Assays in human, mouse, rat PDHX
    QuantiFast Probe-based Assays in human, mouse, rat PDHX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDHX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDHX gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdhx1 , 5 pyruvate dehydrogenase complex, component X1, 5 83.43(n)1
    84.77(a)1
      2 (54.25 cM)5
    274021  NM_175094.51  NP_780303.11 
     1030210755 
    chicken
    (Gallus gallus)
    Aves PDHX1 pyruvate dehydrogenase complex, component X 72.79(n)
    72.24(a)
      423154  NM_001031187.1  NP_001026358.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    79(a)
    52(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    3(189305678-189332307)
    3(54025895-54026706)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW641973.12   -- 77.51(n)    AW641973.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661102 hypothetical protein MGC66110 71.28(n)   393532  BC056571.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52616
    --
    34(a)
    1 ↔ 1
    2L(7426866-7430329)
    worm
    (Caenorhabditis elegans)
    Secernentea C30H6.76
    Protein C30H6.7, isoform a (C30H6.7) mRNA, complet...
    37(a)
    1 ↔ 1
    IV(17380633-17382230) WBGene00007824
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PDX1(YGR193C)4 Dihydrolipoamide dehydrogenase (E3)-binding protein more   --   7(885741-884509) 853107  NP_011709.1 
    soybean
    (Glycine max)
    eudicotyledons CA799463.12   -- 75.09(n)    CA799463.1 
    rice
    (Oryza sativa)
    Liliopsida AK072554.12   -- 70.59(n)    AK072554.1 


    ENSEMBL Gene Tree for PDHX (if available)
    TreeFam Gene Tree for PDHX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PDHX gene
    1 SIMAP similar gene for PDHX using alignment to 4 protein entries:     ODPX_HUMAN (see all proteins):
    DLAT

    Find genes that share paralogs with PDHX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PDHX (see all 1951)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133099411,2
    Cpathogenic134916848(+) CCCTAC/G/TAGGCC 5 Q * stg1 int11CSA 2
    rs1995053651,2
    --34639302(+) ACAAA-/CTGTGAA 3 -- int10--------
    rs1468063571,2
    C--34639303(+) CAAAC-/TGTGAAT 3 -- int10--------
    rs358026891,2
    C--34647248(+) CAAAAG/-CGTTA 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs29561241,2
    C,F,H--34654956(+) TTATTT/AAAAAA 3 -- int1 trp33Minor allele frequency- A:0.33NA 6
    rs1451723631,2
    C--34657331(+) AATAT-/TATAAGT 3 -- int10--------
    rs360614271,2
    C--34657488(+) TTTTT-/TT/TTT
            
    GGTGG
    6 -- int1 cds11NA 2
    rs1129178961,2
    C--34661101(+) TAGACTTAA/-  
            
    CTTTA
    3 -- int11Minor allele frequency- -:0.00CSA 2
    rs39806271,2
    C--34661103(+) AGACT-/AAT   
      T
    /TTAA
    TTAAG
    3 -- int10--------
    rs57910231,2
    C--34661103(+) GACTTAATT/-  
            
    TAAGA
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs31180741,2
    C,F,A--34664108(-) cacacG/Atattt 3 -- int13Minor allele frequency- A:0.33NA WA 6
    rs1403772741,2
    C--34668602(+) TTTCC-/TTTTTTT 3 -- int10--------
    rs38310631,2
    C,F--34677753(-) AAAAA-/ACACAC 3 -- int1 trp34Minor allele frequency- A:0.38NA CSA 8
    rs106339581,2
    C--34678658(+) AGTGCAA/-AGTGT 3 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1411648801,2
    C--34679428(+) TATCA-/AAAC  
            
    AAACA
    3 -- int10--------
    rs1507109141,2
    C--34679431(+) ACAAA-/CAAA  
            
    CAAAA
    3 -- int10--------
    rs345153481,2
    C--34679443(+) ACAAACAAA/-  
            
    AACCA
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs1449288271,2
    C--34693894(+) TTATA-/CTTCTTCT 3 -- cds10--------
    rs1475104331,2
    C--34693895(+) TATAC-/CTTTTCTA 3 -- cds10--------
    rs351768691,2
    C--34695196(+) ATTTTC/-TGCAT 3 -- int11Minor allele frequency- -:0.50NA 2
    rs1449459181,2
    C--34700157(+) GTCAT-/TTTAA 
            
    TTTGT
    3 -- int10--------
    rs721815751,2
    C--34700158(+) TCATT-/TTTAA 
            
    TTGTT
    3 -- int10--------
    rs714573661,2
    C--34700160(+) ATTTTAATTT/
            
    GTTTC
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs57910251,2
    C--34706327(+) AAAAAG/-AAAAG 3 -- int1 trp31Minor allele frequency- -:0.50NA 2
    rs1455537871,2
    C--34707734(+) CCTGA-/GTGT  
            
    GTGTG
    3 -- int10--------
    rs1436538411,2
    C--34707755(+) TGTGT-/GTGT  
     
    /GTGTGT
    ATGTG
    6 -- int1 cds10--------
    rs169264311,2
    C,F--34864318(+) GTCATA/GTGTCA 3 -- us2k110Minor allele frequency- G:0.21NA WA CSA EA 480
    rs788591861,2
    F--34864394(+) GTTCTA/GGGGGA 3 -- us2k11Minor allele frequency- G:0.02WA 118
    rs9846891,2
    C,F,A--34864412(-) gctgcG/Atctgg 3 -- us2k111Minor allele frequency- A:0.21NA WA EA 376
    rs122864361,2
    C--34864413(+) cagatG/Acagct 3 -- us2k16Minor allele frequency- A:0.21NA WA EA 364
    rs1869509311,2
    --34864432(+) TAAATC/TCACAA 3 -- us2k10--------
    rs1902845701,2
    --34864435(+) ATCCAC/TAATGC 3 -- us2k10--------
    rs1811174411,2
    --34864443(+) TGCCTA/GGCACA 3 -- us2k10--------
    rs9846881,2
    A--34864456(-) tgagcA/Gcctac 3 -- us2k10--------
    rs1385945581,2
    --34864466(+) ACTAAA/GTATTC 3 -- us2k10--------
    rs1855698761,2
    --34864719(+) ACCCTC/TTGTAA 3 -- us2k10--------
    rs1895697271,2
    --34864746(+) TAACCA/GCAATC 3 -- us2k10--------
    rs122819141,2
    C,F,H--34864809(+) AAAAGA/CAGCTG 3 -- us2k1 tfbs34Minor allele frequency- C:0.01NS EA WA 390
    rs37639371,2
    C,F,H--34864828(-) TCAAAA/CTCCAG 3 -- us2k116Minor allele frequency- C:0.15NS EA CSA WA NA 2338
    rs1416911331,2
    --34864841(+) TGTTGC/GCTTGG 3 -- us2k10--------
    rs1453384881,2
    --34864894(+) AGCTTA/GGGGGG 3 -- us2k10--------
    rs2015712961,2
    C--34864894(+) AGCTT-/GGGGGG 3 -- us2k10--------
    rs1480433651,2
    --34864918(+) GATAAC/GGAGTT 3 -- us2k10--------
    rs1823023121,2
    --34865000(+) CATGCA/GCCTGT 3 -- us2k10--------
    rs37639361,2
    C,A--34865106(-) CTTGTC/TGCCCA 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs339144971,2
    C--34865148(+) AAAAA-/A/AA  
            
    GGTTG
    3 -- us2k11NA 2
    rs2005397041,2
    --34865185(+) TGCAG-/CAAAAA 3 -- us2k10--------
    rs113681961,2
    C--34865186(+) GCAGC-/AAAAAA 3 -- us2k1 trp30--------
    rs123618841,2
    H--34865227(+) GGCCAT/CGTTTG 3 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 370
    rs37639351,2
    C,F,A--34865266(-) AGCCTT/GAAGGG 3 -- us2k18Minor allele frequency- G:0.21NA WA CSA EA 486
    rs1861630301,2
    --34865279(+) CTTTGA/GTGCTC 3 -- us2k10--------
    rs1505947521,2
    --34865325(+) GGGTAA/CGGACA 3 -- us2k10--------
    rs729304681,2
    C,F--34865396(+) TCTCTC/ATCTCA 3 -- us2k11Minor allele frequency- A:0.42NA 120
    rs1396046561,2
    --34865425(+) GCATTC/TTATTT 3 -- us2k10--------
    rs37639341,2
    C,F,H--34865652(-) ATAAGC/TAGTTT 3 -- us2k127Minor allele frequency- T:0.21NA NS EA WA CSA 2900
    rs37941701,2
    C,F,A,H--34865714(-) TCTACA/GCGCTC 3 -- us2k119Minor allele frequency- G:0.16EA NS NA WA 3832
    rs1921136161,2
    --34865718(+) GTGTAA/GAAGGC 3 -- us2k10--------
    rs794384051,2
    C,F--34865719(+) TGTAGA/GAGGCG 3 -- us2k11Minor allele frequency- G:0.06NA 120
    rs1836191281,2
    --34865721(+) TAGAAA/GGCGCT 3 -- us2k10--------
    rs1149717941,2
    F--34865750(+) GTGTAA/GATGAC 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs750661041,2
    C--34865875(+) TCAAAG/TGCAAA 3 -- us2k10--------
    rs37639331,2
    C,F,H--34865906(-) CGAACC/AGGAGC 3 -- us2k121Minor allele frequency- A:0.17EA NS NA WA CSA 3444
    rs37639321,2
    C,F,A--34865939(-) TGGGGG/AGACGT 3 -- us2k17Minor allele frequency- A:0.12EA WA NA CSA 1657
    rs1438426171,2
    --34865984(+) GCTTGA/GGGGGC 3 -- us2k10--------
    rs37639311,2
    C,F,H--34865992(-) AAGACC/TGCGCC 3 -- us2k119Minor allele frequency- T:0.21NS EA WA NA CSA 2344
    rs37639301,2
    C,F,A--34866062(+) ACCCGG/CTGAGG 3 -- us2k112Minor allele frequency- C:0.12EA NA WA CSA 1558
    rs20168211,2
    C,F,A--34866177(+) CTCGCT/AGCCTT 3 -- us2k1 tfbs313Minor allele frequency- A:0.42MN NA EA WA 934
    rs1882066701,2
    --34866205(+) TCGCGA/GTGCGC 3 -- us2k10--------
    rs359240421,2
    C,F--34866257(+) TAAACA/C/G/
            
    CCCGG
    9 -- ut511NA 2
    rs20168141,2
    C,F,A--34866273(+) TACCCC/TGCGCC 3 -- ut519Minor allele frequency- T:0.18MN NA CSA WA EA 553
    rs169264481,2
    C,F--34866274(+) ACCCTG/ACGCCC 3 -- ut517Minor allele frequency- A:0.17MN EA NA WA 738
    rs1998932421,2
    --34866346(+) CCGCCC/TCTACC 3 -- ut510--------
    rs2022412861,2
    --34866349(+) CCCCTA/GCCTGC 3 -- ut510--------
    rs1391239791,2
    C--34866368(+) TCTCCG/AGGAAC 3 -- ut511Minor allele frequency- A:0.00NA 3788
    rs29561141,2
    C,F,A,H--34866389(-) ATGCTC/TGGGAG 3 -- ut5127Minor allele frequency- T:0.35NA NS EA WA EU 6731
    rs29561131,2
    C,F,A--34866460(-) AGCGCC/TGCGCG 3 -- ut517Minor allele frequency- T:0.40NA WA EA 366
    rs29561121,2
    C,F,H--34866477(-) TGCCGC/TATCCC 3 -- ut5117Minor allele frequency- T:0.20NA NS EA WA CSA 858
    rs29561111,2
    C,F,A--34866507(-) AGCGCC/TGCCTG 4 S G ut51 mis19Minor allele frequency- T:0.46NA WA EA 370
    rs1130732421,2
    C,F--34866577(+) GGCTGA/GGATAT 4 E G ut51 mis14Minor allele frequency- G:0.21CSA WA NA EA 362
    rs1399997351,2
    C--34866648(+) TGGGG-/GGCGGGGG 3 -- cds1 int10--------
    rs29561101,2
    C,F,A,H--34866691(-) CCCCAT/GACGCT 3 -- ut51 int110Minor allele frequency- G:0.42NA WA EA 372
    rs2010333641,2
    C--34866756(+) GCGGGA/CAGCCA 3 -- ut51 int10--------
    rs38184011,2
    C,F,A,H--34866775(-) ATCTTG/CACGGC 3 -- ut51 int1 ese310Minor allele frequency- C:0.17NS EA CSA WA NA EU 1495
    rs2004191511,2
    --34866813(+) TCCGCC/GGCTGC 5 P R mis1 int10--------
    rs1181364281,2
    C,F--34866825(+) GCGTTA/CTCTTG 5 Y S mis1 int11Minor allele frequency- C:0.03EA 120
    rs1825698821,2
    C--34866827(+) GTTATC/TTTGTG 5 L F mis1 int10--------
    rs29561091,2
    C,F,H--34866841(-) CGGCCA/GGGGAA 5 P syn1 int1 ese312Minor allele frequency- G:0.20NA WA CSA EA EU 5481
    rs10493061,2,,4
    C,F,A,H--34866845(+) CCGGCC/TGCCGA 5 R C mis1 int1 ese325Minor allele frequency- T:0.20MN NS EA NA WA CSA EU 8081
    rs115392011,2
    C,F--34866848(+) GCCGCC/GGAAGC 5 R G mis1 int14Minor allele frequency- G:0.02NA EU 5111
    rs10493071,2
    C,F,A,H--34866886(+) TGGTCT/CGTAAG 5 /S syn1 int1 ese327Minor allele frequency- C:0.20NA MN NS EA WA CSA EU 6988
    rs1873041891,2
    C--34866953(+) CGGGGC/GTCGCT 3 -- int10--------
    rs38183971,2
    C,F,A--34867032(-) CACCTT/CCACAC 3 -- int16Minor allele frequency- C:0.22WA CSA NA EA 365
    rs38183961,2
    C,F,A--34867127(-) TTCTCT/CCAGCT 3 -- int18Minor allele frequency- C:0.22NA WA CSA EA 369
    rs18872291,2
    C,F--34867227(-) GAGGAG/AAGTTT 3 -- int1 trp32Minor allele frequency- A:0.00NA 4
    rs1913414431,2
    --34867256(+) TCAAGA/GCTCAG 3 -- int10--------
    rs29864141,2
    C,F,O,A,H--34867359(-) AGAGGC/TCTAGA 3 -- int114Minor allele frequency- T:0.43NA WA EA 496
    rs38183931,2
    C,F,H--34867416(-) GAGTCA/GTGGCG 3 -- int119Minor allele frequency- G:0.21NS EA NA WA CSA 2344
    rs1485668111,2
    --34867447(+) AATTCC/TTACGG 3 -- int10--------
    rs37639291,2
    C,F,H--34867511(-) ATGTTT/CGCTCT 3 -- int111Minor allele frequency- C:0.20NS EA NA WA CSA 742
    rs1145087751,2
    C,F--34867525(+) GGAGAT/GAAATC 3 -- int11Minor allele frequency- G:0.02NA 120
    rs29561081,2
    C,F,O,A,H--34867538(-) AAATTC/TTTGGT 3 -- int113Minor allele frequency- T:0.39NA WA EA 494
    rs1839670771,2
    --34867599(+) CTTGCA/GGTATT 3 -- int10--------
    rs1906036171,2
    --34867777(+) GTAGAC/TGTTGC 3 -- int10--------
    rs37639271,2
    C,F--34867800(-) CTAAGG/TTAGCT 3 -- int11Minor allele frequency- T:0.04EA 1494
    rs37639261,2
    C,F,H--34867868(-) AGGAAC/TCTTTA 3 -- int111Minor allele frequency- T:0.21NS EA NA WA CSA 784
    rs1511200291,2
    --34867966(+) CCTTCC/TCTTCC 3 -- int10--------
    rs1930248941,2
    --34868009(+) CCAGCG/TCCTAG 3 -- int10--------
    rs1413819161,2
    C--34868017(+) TAGAGA/GTTCGG 3 -- int10--------
    rs785104091,2
    C--34868019(+) GAGATT/GCGGTC 3 -- int14Minor allele frequency- G:0.17CSA WA NA EA 360
    rs1171293251,2
    F--34868043(+) GGCTCA/GGGAAT 3 -- int11Minor allele frequency- G:0.02EA 120
    rs1857062611,2
    --34868073(+) GATGAA/GTTTTG 3 -- int10--------
    rs116056001,2
    C,F,H--34868092(+) TTTTGA/GCATTT 3 -- int110Minor allele frequency- G:0.18NA NS EA 686
    rs1147345471,2
    F--34868113(+) GCTTTG/AAGACT 3 -- int11Minor allele frequency- A:0.05WA 118
    rs37639251,2
    C,H--34868207(-) AAAAGG/AATCTG 3 -- int18Minor allele frequency- A:0.12NS EA NA WA 660
    rs1451621831,2
    --34868237(+) ACAGAC/TTCTCT 3 -- int10--------
    rs1898901471,2
    C--34868326(+) GAGGCA/GAAGCT 3 -- int10--------
    rs116014791,2
    H--34868447(+) cccagC/Ttactc 3 -- int10--------
    rs1466780121,2
    --34868506(+) ATTGAA/GCTATG 3 -- int10--------
    rs1815976441,2
    --34868525(+) GCTGCA/TCTTTA 3 -- int10--------
    rs1402280651,2
    --34868628(+) AGCAAC/TCCTTA 3 -- int10--------
    rs1453770851,2
    --34868635(+) CTTATA/CTGCAT 3 -- int10--------
    rs1839111281,2
    --34868685(+) ATATAC/TCATGA 3 -- int10--------
    rs1379679961,2
    --34868707(+) ACCCCA/CGTTTG 3 -- int10--------
    rs1171267491,2
    F--34868868(+) TAACTA/GGGCTA 3 -- int11Minor allele frequency- G:0.01NA 120
    rs1490901881,2
    --34868893(+) GTAGGA/TGCTGC 3 -- int10--------
    rs1431108161,2
    --34868917(+) GGCTCA/GAGACC 3 -- int10--------
    rs37639241,2
    C,F--34868928(-) TAAGGG/CAATGG 3 -- int16Minor allele frequency- C:0.22NA WA CSA EA 364
    rs1149117931,2
    C,F--34868981(+) GGGCTT/CCAAAG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs29864131,2
    C,F,H--34869021(-) AGTGAT/CGTAAT 3 -- int116Minor allele frequency- C:0.22NS EA NA WA CSA 800
    rs1482735311,2
    --34869111(+) TTTCCC/TCATCT 3 -- int10--------
    rs29561071,2
    C,F,A,H--34869143(-) AAAGAT/CGGAAT 3 -- int115Minor allele frequency- C:0.46NS EA NA WA 790
    rs1886481361,2
    --34869160(+) AATTCC/TCTCTT 3 -- int10--------
    rs1808204361,2
    --34869302(+) ATACCC/GAGCCA 3 -- int10--------
    rs104888011,2
    C,F,H--34869312(+) AAAATA/GTATCC 3 -- int1106Minor allele frequency- G:0.13NS NA EA PA EU CA WA CSA 6868
    rs1852268621,2
    --34869349(+) TTTTTC/GTTTTG 3 -- int10--------
    rs122767351,2
    C,F,H--34869417(+) GTGGTG/ATTTTT 3 -- int110Minor allele frequency- A:0.21NS EA NA WA CSA 784
    rs169264571,2
    C,F,H--34869480(+) TTACTG/ATAAAC 3 -- int18Minor allele frequency- A:0.05NA NS EA WA 642
    rs29561061,2
    C,F,A,H--34869555(-) AGTTCT/CGACTG 3 -- int1107Minor allele frequency- C:0.36NS EA NA PA EU CA WA 6854
    rs29561051,2
    C,F,O,A,H--34869598(-) AAATGA/CTGCCA 3 -- int110Minor allele frequency- C:0.39NA WA EA 508
    rs1910596231,2
    --34869608(+) TTTATA/GAGCTA 3 -- int10--------
    rs122837631,2
    C,F,H--34869621(+) ACATAT/GGCCAT 3 -- int111Minor allele frequency- G:0.20NS EA NA WA CSA 786
    rs29152051,2
    C,F,O,A,H--34869661(-) TGTGAG/AAAGTG 3 -- int129Minor allele frequency- A:0.46NS EA NA WA 2902
    rs74798231,2
    C,F,H--34869671(+) ATAACC/GTAGTA 3 -- int190Minor allele frequency- G:0.05NS EA NA PA EU CA WA 4600
    rs618811331,2
    C,F--34869700(+) TTTAGT/CTGGAC 3 -- int12Minor allele frequency- C:0.04NA 122
    rs1819268141,2
    --34869725(+) TTAGAC/GAAATT 3 -- int10--------
    rs1429414591,2
    --34869920(+) ATTAGG/TTGCCA 3 -- int10--------
    rs110329251,2
    C--34869931(+) GGCACA/GTGGTA 3 -- int16Minor allele frequency- G:0.21NA WA EA 364
    rs110329261,2
    C,F,A,H--34869937(+) TGGTAC/GCCTGC 3 -- int18Minor allele frequency- G:0.12NS EA WA CSA NA 646
    rs1875623761,2
    --34870029(+) ATGCAA/GTCCAA 3 -- int10--------
    rs7247141,2
    C,F,A,H--34870067(+) TATTTA/GTAGTC 3 -- int131Minor allele frequency- G:0.20NA NS EA WA CSA 4702
    rs1915184881,2
    --34870072(+) GTAGTC/TTCTTT 3 -- int10--------
    rs1474286231,2
    C--34870108(+) TTTCAA/GTAGTG 3 -- int10--------
    rs765075641,2
    C,F--34870170(+) TAAGGC/AAGCTT 3 -- int11Minor allele frequency- A:0.03NA 120
    rs1831347071,2
    --34870264(+) TGACAA/CAGCAT 3 -- int10--------
    rs1871707631,2
    --34870297(+) CTCTAC/GACAGT 3 -- int10--------
    rs776983521,2
    F--34870326(+) ATTGTG/AGTCCT 3 -- int11Minor allele frequency- A:0.02NA 120
    rs29152041,2
    C,F,A,H--34870418(-) TTCAAC/TATGTT 3 -- int114Minor allele frequency- T:0.45NS EA NA WA 770
    rs29152031,2
    C,F,O,A--34870449(-) AGTTAT/CTTTTC 3 -- int114Minor allele frequency- C:0.18NA WA CSA EA 514
    rs1904102691,2
    C--34870462(+) GGTTCA/CATCTT 3 -- int10--------
    rs1390720051,2
    C--34870473(+) GGTGGC/TGATTT 3 -- int10--------
    rs789826971,2
    C,F--34870486(+) CTAGTA/GTATAA 3 -- int12Minor allele frequency- G:0.25CSA WA 120
    rs37941661,2
    C,F--34870542(-) ATTACT/CAGCTT 3 -- int110Minor allele frequency- C:0.20NA WA CSA EA 508
    rs1429732671,2
    C--34870580(+) CCTACA/GGTAGG 3 -- int10--------
    rs173486971,2
    C,F,H--34870583(+) ACAGTA/GGGATT 3 -- int18Minor allele frequency- G:0.18NA NS EA 680
    rs1827177771,2
    --34870632(+) GCAGAA/CAAACT 3 -- int10--------
    rs562044511,2
    C,F--34870721(+) CCTATG/ATGGTG 3 -- int12Minor allele frequency- A:0.07WA 120
    rs1508562851,2
    --34870774(+) GAAATG/TGCTTC 3 -- int10--------
    rs1874466481,2
    --34870824(+) AGCAAA/GGCTGA 3 -- int10--------
    rs801388131,2
    C,F--34870843(+) TGGTAT/ATTGCA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs173487111,2
    C,F,H--34870886(+) TCTTAT/CCTCTA 3 -- int121Minor allele frequency- C:0.16NA NS EA 2236
    rs1155174591,2
    C,F--34870974(+) TATCCA/GTTTAA 3 -- int11Minor allele frequency- G:0.03WA 118
    rs29864081,2
    C,F,O,A,H--34871092(+) ATAACA/CAGGAG 3 -- int118Minor allele frequency- C:0.21NA NS EA WA CSA 932
    rs754919211,2
    F--34871128(+) ATGGTA/GTGGTA 3 -- int11Minor allele frequency- G:0.02WA 118
    rs1927644881,2
    --34871147(+) AAAACA/GCGGAT 3 -- int10--------
    rs174334961,2
    C,F,H--34871149(+) AACACG/AGATAC 3 -- int120Minor allele frequency- A:0.16NA NS EA 2138
    rs1854296711,2
    --34871180(+) TTAAGC/TGCTTA 3 -- int10--------
    rs1500377161,2
    --34871193(+) CACTGA/GTAAGA 3 -- int10--------
    rs1443633741,2
    --34871342(+) CATCTA/GTTTCT 3 -- int10--------
    rs110329271,2
    C,F,H--34871409(+) ACTTGC/GAATTA 3 -- int127Minor allele frequency- G:0.21NS EA NA WA CSA 2914
    rs794333331,2
    F--34871498(+) ATGCGC/GTGTCA 3 -- int11Minor allele frequency- G:0.04NA 120
    rs1891843611,2
    --34871533(+) TTTCTA/GTAATC 3 -- int10--------
    rs3716440731,2
    --34871571(+) AAACT-/GACG  
            
    GACCC
    3 -- int10--------
    rs1919874661,2
    --34871630(+) GGCTAC/TGATTT 3 -- int10--------
    rs759262941,2
    C,F--34871760(+) TTCTGC/TGCTAA 3 -- int11Minor allele frequency- T:0.05WA 118
    rs29152021,2
    C,F,O,H--34871806(-) GCCTAG/CAAGTG 3 -- int132Minor allele frequency- C:0.20NA NS EA WA CSA 2918
    rs122820981,2
    C,F,H--34872068(+) TTCACG/AGGAGA 3 -- int1 trp319Minor allele frequency- A:0.21NS EA NA WA CSA 2342
    rs1401258771,2
    --34872184(+) ACCTTC/TCTTCT 3 -- int10--------
    rs29152011,2
    C,F,O,H--34872324(-) TCTATC/ACATTT 3 -- int132Minor allele frequency- A:0.21NA NS EA WA CSA 2921
    rs1131359551,2
    C--34872331(+) TAGAC-/TTTGGC 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs122954081,2
    C,F,H--34872531(+) TTAATA/GCTCAC 3 -- int18Minor allele frequency- G:0.15NS EA WA CSA NA 632
    rs1439386211,2
    --34872677(+) CTGACA/GTTTTA 3 -- int10--------
    rs1844942941,2
    --34872692(+) TCACCA/GTGTGT 3 -- int10--------
    rs729304801,2
    C,F--34872741(+) GAAATC/TAGACA 3 -- int11Minor allele frequency- T:0.41NA 120
    rs1885004471,2
    --34872758(+) TAACCA/GCATTG 3 -- int10--------
    rs1468720911,2
    --34872774(+) TAGCAG/TTTCTG 3 -- int10--------
    rs122704871,2
    C,F--34872789(+) AGCCTA/GTCATT 3 -- int19Minor allele frequency- G:0.20NA WA EA 506
    rs29152001,2
    C,F,A,H--34872945(-) AGGCAG/AATTAA 3 -- int123Minor allele frequency- A:0.42NS EA NA WA 2346
    rs1810526691,2
    --34872947(+) AATTTC/GCCTTT 3 -- int10--------
    rs753264381,2
    C,F--34872956(+) TTTACG/AACAAA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1137838211,2
    C--34872985(+) ATCGT-/G/TGTG
            
    TGTGT
    3 -- int11CSA 2
    rs1848916681,2
    --34872987(+) TCGTTG/TTGTGT 3 -- int10--------
    rs110329281,2
    C,A,H--34873021(+) TGTGTG/ATGTAT 3 -- int11Minor allele frequency- A:0.50WA 2
    rs670063351,2
    C--34873024(+) GTATGTATT/-  
            
    CTTTT
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs29561031,2
    C,F,A,H--34873027(-) AAAAGC/AATACA 3 -- int114Minor allele frequency- A:0.42NS EA WA NA 1980
    rs1890590491,2
    --34873041(+) AGGCTG/TTAAAT 3 -- int10--------
    rs13269441,2
    C,F,A,H--34873098(+) GTGAAA/CTTCAT 3 -- int125Minor allele frequency- C:0.19NS EA NA WA CSA 2350
    rs13269451,2
    C,F,O,A,H--34873140(+) GAAGGC/ACAGTA 3 -- int115Minor allele frequency- A:0.20NA WA CSA EA 518
    rs1402465731,2
    --34873209(+) CTACAC/TCATAT 3 -- int10--------
    rs1809672601,2
    --34873239(+) TAACCG/TCTTTT 3 -- int10--------
    rs1424927431,2
    --34873408(+) GACTTA/TATTAT 3 -- int10--------
    rs800905431,2
    F--34873419(+) ATGAAA/GCATTC 3 -- int13Minor allele frequency- G:0.07CSA WA 121
    rs1871110331,2
    --34873535(+) TATACC/GACTAA 3 -- int10--------
    rs1925014481,2
    --34873609(+) TCTCCC/GTGTAA 3 -- int10--------
    rs113477821,2
    C--34873756(+) GTGTTC/-CATCA 3 -- int12Minor allele frequency- -:0.00NA 4
    rs29864091,2
    C,F,O,A,H--34873801(+) CTAATG/AGCATT 3 -- int115Minor allele frequency- A:0.44NA WA EA 516
    rs1815760541,2
    --34873802(+) TAATGA/GCATTT 3 -- int10--------
    rs1859393251,2
    --34874018(+) GGTTTC/TCAAGT 3 -- int10--------
    rs169264791,2
    C,F,H--34874022(+) TTCAAG/ATATGA 3 -- int111Minor allele frequency- A:0.05NA NS EA WA 800
    rs1906584361,2
    C--34874045(+) ATAGAG/TATCAA 3 -- int10--------
    rs1509603351,2
    --34874199(+) ACAATA/GTTGTG 3 -- int10--------
    rs173490311,2
    C,F--34874297(+) TGCCCA/GTCAAA 3 -- int13Minor allele frequency- G:0.01NA 142
    rs568980191,2
    C--34874400(+) TCTGTC/TGCCCA 3 -- int14Minor allele frequency- T:0.22CSA WA NA EA 360
    rs765650661,2
    C,F--34874404(+) TCGCCC/TAGACT 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1501131711,2
    --34874529(+) AAAGAC/TGGGCT 3 -- int10--------
    rs614469411,2
    C,F--34874550(+) TGTCCT/AGGCTG 3 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1883368151,2
    --34874564(+) TTGAAA/CTTCTG 3 -- int10--------
    rs1413175061,2
    --34874587(+) CCACCA/CGCCTC 3 -- int10--------
    rs793768321,2
    C--34874688(+) GAGAAG/AAGGAA 3 -- int14Minor allele frequency- A:0.16CSA WA NA EA 360
    rs1907313011,2
    --34874740(+) GAAATA/TAGAGC 3 -- int10--------
    rs29151991,2
    C,F,O,A,H--34874741(-) GGCTCA/TAATTT 3 -- int120Minor allele frequency- T:0.21NS EA NA WA CSA 1214
    rs2003968551,2
    --34874741(+) AAATT-/AGAGCC 3 -- int10--------
    rs2014752461,2
    --34874741(+) AATTA-/TGAGCC 3 -- int10--------
    rs607743281,2
    C--34874876(+) GTTTAA/GATAGT 3 -- int15Minor allele frequency- G:0.21WA CSA NA EA 361
    rs603462811,2
    C--34874880(+) AAATAG/ATACTG 3 -- int15Minor allele frequency- A:0.22WA CSA NA EA 361
    rs1829511421,2
    --34875005(+) TGTTTC/GTATTT 3 -- int10--------
    rs1470168401,2
    --34875007(+) TTTCTA/GTTTTA 3 -- int10--------
    rs1381769311,2
    --34875090(+) TCTTGC/GTCAAA 3 -- int10--------
    rs79509961,2
    C,F,A,H--34875285(+) GCCACA/GTCAGA 3 -- int116Minor allele frequency- G:0.17NS EA NA 1808
    rs1430149451,2
    --34875540(+) TATTAC/TGTATC 3 -- int10--------
    rs1446558321,2
    --34875541(+) ATTACA/GTATCT 3 -- int10--------
    rs37941651,2
    C,F,A,H--34875613(-) TTTAAG/ACAGAA 3 -- int19Minor allele frequency- A:0.20NS EA WA CSA NA 778
    rs29151981,2
    C,F,A,H--34875629(-) GTTTGT/CTTTTG 3 -- int113Minor allele frequency- C:0.22NS EA NA WA 782
    rs122864121,2
    C,F,H--34875762(+) TAATAT/CCACTA 3 -- int110Minor allele frequency- C:0.06NS EA NA WA 1208
    rs1480866981,2
    --34875836(+) GGGCAA/GGTAGT 3 -- int10--------
    rs1419143811,2
    --34875839(+) CAGGTA/GGTAAT 3 -- int10--------
    rs122927191,2
    C,F,A,H--34876069(+) CCCAAA/GCATTT 3 -- int19Minor allele frequency- G:0.21NS EA WA CSA NA 782
    rs1506377621,2
    --34876085(+) AAGGCA/TTACTC 3 -- int10--------
    rs787728951,2
    C,F--34876107(+) TGCTTA/GTGGGT 3 -- int12Minor allele frequency- G:0.07WA 120
    rs729129071,2
    C--34876182(+) CATTCA/CTTTTC 3 -- int10--------
    rs768419391,2
    F--34876202(+) CCATTG/AACATT 3 -- int11Minor allele frequency- A:0.01EA 120
    rs104888021,2
    C,F,H--34876266(+) GACTTA/GTATGA 3 -- int126Minor allele frequency- G:0.16NS NA EA 2336
    rs1997436161,2
    --34876289(+) AAAAC-/AAAAAA 3 -- int10--------
    rs1926535221,2
    --34876339(+) TGTGCC/TTAGTG 3 -- int10--------
    rs79419301,2
    C,F,A,H--34876437(+) AAGGCT/CCCGTT 3 -- int118Minor allele frequency- C:0.15NS EA NA CSA WA 2342
    rs774423721,2
    C,F--34876449(+) TATTTA/GGTGTG 3 -- int11Minor allele frequency- G:0.01NA 120
    rs99716071,2
    C,F,H--34876460(+) TTCTGA/GCATTG 3 -- int15Minor allele frequency- G:0.02NS EA WA 536
    rs803517951,2
    C,F--34876499(+) CTCTCC/TCTATT 3 -- int12Minor allele frequency- T:0.04WA 120
    rs19989121,2
    C,F,O,A,H--34876517(+) AAGCAC/AATTAA 3 -- int131Minor allele frequency- A:0.41MN NA NS EA WA 3000
    rs1847379631,2
    --34876741(+) TAACCA/GTAAAG 3 -- int10--------
    rs1401455451,2
    --34876756(+) TTGTTC/GTGCAT 3 -- int10--------
    rs1998409281,2
    --34876868(+) TGCTG-/AAGTATGA
    GCATTTTGTTC
    AAGTA
    3 -- int10--------
    rs1872065451,2
    --34876886(+) TTTGTC/TCTTAG 3 -- int10--------
    rs746552291,2
    F--34876924(+) AAACTA/CGAATT 3 -- int12Minor allele frequency- C:0.21CSA WA 120
    rs1921854801,2
    --34877014(+) GAATTG/TCTTAG 3 -- int10--------
    rs1846075061,2
    --34877060(+) CTCATA/GTAGCA 3 -- int10--------
    rs1169047191,2
    C,F--34877118(+) ATTGTG/ATCATT 3 -- int11Minor allele frequency- A:0.02NA 120
    rs29864101,2
    C,F,A,H--34877158(+) TATGAG/ATCATG 3 -- int124Minor allele frequency- A:0.47NA NS EA WA 2368
    rs128040061,2
    H--34877208(+) ACTGGA/CCCACA 3 -- int14Minor allele frequency- C:0.00NS EA 418
    rs724928711,2
    C--34877347(+) AAAAC-/GGTTAA 3 -- int10--------
    rs104888031,2
    C,F,H--34877400(+) AACTTG/CTGTAA 3 -- int117Minor allele frequency- C:0.16NS NA EA WA CSA 910
    rs104888041,2
    C,F,H--34877449(+) TAATAC/GTAGGA 3 -- int118Minor allele frequency- G:0.16NS NA EA WA CSA 912
    rs797421771,2
    C,F--34877609(+) TCTAGA/CAAAGT 3 -- int12Minor allele frequency- C:0.07WA 120
    rs29151971,2
    C,F,O,A,H--34877689(-) GATAAG/ACTTGA 3 -- int114Minor allele frequency- A:0.20NA WA CSA EA 516
    rs173492981,2
    C,F,H--34877771(+) AAGAGG/TGTATG 3 -- int18Minor allele frequency- T:0.18NA NS EA 680
    rs802874891,2
    C,F--34877807(+) AACACA/GTTAAT 3 -- int11Minor allele frequency- G:0.03NA 120
    rs1148486491,2
    --34877814(+) TAATGC/TTTATG 3 -- int10--------
    rs1463982501,2
    --34877840(+) CATGAA/GAGCCT 3 -- int10--------
    rs29864111,2
    F,H--34877843(+) GAAAGC/GCTGAG 3 -- int14Minor allele frequency- G:0.00NS EA 418
    rs1923033431,2
    C--34877858(+) GATTAC/GTTAGA 3 -- int10--------
    rs122699701,2
    C,H--34877870(+) TAACTA/GCAAAA 3 -- int14Minor allele frequency- G:0.00NS EA 412
    rs1846493301,2
    --34877992(+) AGAGTA/GAAGAT 3 -- int10--------
    rs122834721,2
    C,F,H--34878075(+) CTAAGG/AAACGA 3 -- int117Minor allele frequency- A:0.08NS EA NA WA 2340
    rs1177449561,2
    F--34878144(+) GAAAGA/TTAATA 3 -- int11Minor allele frequency- T:0.04NA 120
    rs122834351,2
    C,F,H--34878186(+) AATGTC/TAAGAG 3 -- int14Minor allele frequency- T:0.00NS EA 412
    rs793823791,2
    C,F--34878299(+) ATATTG/AGAGAG 3 -- int11Minor allele frequency- A:0.04WA 118
    rs1145849361,2
    F--34878335(+) TTTGTC/TGTAAA 3 -- int11Minor allele frequency- T:0.03WA 118
    rs108363221,2
    C,F,A--34878439(+) AAATAT/CTCTGT 3 -- int110Minor allele frequency- C:0.42NA WA EA 372
    rs764895171,2
    --34878517(+) GTTTTC/TGAAAA 3 -- int10--------
    rs1154665271,2
    C,F--34878533(+) TGGCCT/GCTTAC 3 -- int11Minor allele frequency- G:0.03WA 118
    rs104663921,2
    C,F,H--34878564(+) AAGAGT/GTTTTT 3 -- int17Minor allele frequency- G:0.15NS EA WA NA 616
    rs1817786841,2
    --34878578(+) GCCCAC/TCCCCC 3 -- int10--------
    rs2016536761,2
    C--34878600(-) TGGGGA/GANNNN 3 -- int10--------
    rs1498793741,2
    --34878669(+) AGTACA/CTTCTT 3 -- int10--------
    rs1865134251,2
    --34878688(+) TGTTTC/TTGATT 3 -- int10--------
    rs1889464001,2
    --34878746(+) TAGTGC/TAGAGG 3 -- int10--------
    rs29560811,2
    C,F,O,A,H--34878769(+) ATTCTC/GTTATC 3 -- int1