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PDGFRL Gene

protein-coding   GIFtS: 55
GCID: GC08P017436

Platelet-Derived Growth Factor Receptor-Like

  See PDGFRL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet-Derived Growth Factor Receptor-Like1 2     PDGRL2 5
PRLTS2 3 5     Platelet-Derived Growth Factor Receptor-Like Protein2
PDGF Receptor Beta-Like Tumor Suppressor2 3     Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor2
PDGFR-Like Protein2 3     

External Ids:    HGNC: 88051   Entrez Gene: 51572   Ensembl: ENSG000001042137   OMIM: 6045845   UniProtKB: Q151983   

Export aliases for PDGFRL gene to outside databases

Previous GC identifers: GC08P017327 GC08P017514 GC08P017444 GC08P017478 GC08P017435 GC08P015978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDGFRL Gene:
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived
growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene,
are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This
suggests this gene product may function as a tumor suppressor. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDGFRL Gene:
PDGFRL (platelet-derived growth factor receptor-like) is a protein-coding gene. Diseases associated with PDGFRL include hepatocellular carcinoma, somatic, and colonic adenoma recurrence, reduced risk of. GO annotations related to this gene include platelet-derived growth factor beta-receptor activity and platelet activating factor receptor activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDGFRL gene promoter:
         HFH-3   TBP   Pbx1a   Tal-1   Pax-2   FOXD3   CUTL1   E4BP4   E47   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDGFRL promoter sequence
   Search Chromatin IP Primers for PDGFRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDGFRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21.3   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22-p21.3

PDGFRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFRL gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P017436:  view genomic region     (about GC identifiers)

Start:
17,433,942 bp from pter      End:
17,501,580 bp from pter
Size:
67,639 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198 (See protein sequence)
Recommended Name: Platelet-derived growth factor receptor-like protein precursor  
Size: 375 amino acids; 41861 Da
Subunit: Forms a complex composed of PDGFRL, TNK2 and GRB2
Secondary accessions: A8K085 Q6FH04

Explore the universe of human proteins at neXtProt for PDGFRL: NX_Q15198

Explore proteomics data for PDGFRL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn132, Asn219
  • Modification sites at PhosphoSitePlus

  • See PDGFRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006198.1  
    ENSEMBL proteins: 
     ENSP00000251630   ENSP00000444211   ENSP00000381149  

    PDGFRL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PDGFRL

     
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    Search eBioscience for ELISAs for PDGFRL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q15198

    ProtoNet protein and cluster: Q15198

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with PDGFRL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for PDGFRL:
    platelet-derived growth factor receptor-like

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004992platelet activating factor receptor activity TAS7898930
    GO:0005019platelet-derived growth factor beta-receptor activity TAS7898930
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PDGFRL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDGFRL:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDGFRL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDGFRL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDGFRL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDGFRL

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDGFRL:
    hsa-mir-26b-5p (MIRT029428), hsa-mir-25-3p (MIRT050268)

    Block miRNA regulation of human, mouse, rat PDGFRL using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PDGFRL:
    hsa-miR-3163 hsa-miR-633 hsa-miR-617
    SwitchGear 3'UTR luciferase reporter plasmidPDGFRL 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PDGFRL 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGFRL_HUMAN, Q15198: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with PDGFRL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PDGFRL: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PDGFRL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for PDGFRL (ENSP000002516304) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BOCENSP000003475464STRING: ENSP00000347546
    CHADENSP000002589694STRING: ENSP00000258969
    DCNENSP000000527544STRING: ENSP00000052754
    EPYCENSP000002611724STRING: ENSP00000261172
    HAPLN2ENSP000002550394STRING: ENSP00000255039
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS7898930
    GO:0008150biological_process ND--
    GO:0035791platelet-derived growth factor receptor-beta signaling pathway TAS7898930

    Find genes that share ontologies with PDGFRL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PDGFRL (see all 14)     About this table
    CompoundAction CAS #
    Amuvatinib (MP-470, HPK 56)Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3[850879-09-3]
    Crenolanib (CP-868596)Potent and selective PDGFR-beta inhibitor[670220-88-9]
    Flumatinib mesylatemulti-kinase inhibitor for c-Abl, PDGFRbeta and c-Kit[895519-91-2]
    Imatinib Mesylate (STI571)Multi-target kinase inhibitor of abl, c-kit, and PDGFR[220127-57-1]
    Masitinib (AB1010)tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor[790299-79-5]
    MK-2461potent inhibitor of Met, Ron, Flt1, Flt 3, PDGFRbeta, and Mer with IC50 of 2.5 nM, 7 nM, 10 nM, 22 nM, 22 nM and 24 nM, respectively[917879-39-1]
    Nintedanib (BIBF 1120)Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR[928326-83-4]
    Pazopanib (GW-786034)Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR[635702-64-6]
    Ponatinib (AP24534)pan-BCR-ABL inhibitor[943319-70-8]
    RegorafenibMulti-kinase inhibitor, inhibits VEGFR, PDGFR, FGFR, mutant kit, RET, and Raf-1[755037-03-7]

    Browse Tocris compounds for PDGFRL (PGFRL)

    1 Novoseek inferred chemical compound relationship for PDGFRL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 9.5 2 1717981 (1), 9476070 (1)



    Find genes that share compounds with PDGFRL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDGFRL gene: 
    NM_006207.2  

    Unigene Cluster for PDGFRL:

    Platelet-derived growth factor receptor-like
    Hs.458573  [show with all ESTs]
    Unigene Representative Sequence: NM_006207
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251630 ENST00000523248 ENST00000541323(uc003wxr.3) ENST00000398074

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDGFRL using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PDGFRL:
    hsa-miR-3163 hsa-miR-633 hsa-miR-617
    SwitchGear 3'UTR luciferase reporter plasmidPDGFRL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PDGFRL
    Predesigned siRNA for gene silencing in human, mouse, rat PDGFRL
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      QuantiTect SYBR Green Assays in human, mouse, rat PDGFRL
      QuantiFast Probe-based Assays in human, mouse, rat PDGFRL

    Additional mRNA sequence: 

    AK289450.1 BC010927.1 CR541952.1 D37965.1 

    4 DOTS entries:

    DT.100700736  DT.440990  DT.121480841  DT.451623 

    Selected AceView cDNA sequences (see all 106):

    AI264744 BU624775 CR596869 D62559 BI754977 BQ010346 AA347805 AA461197 
    BQ575319 BQ014860 CB268406 BM671983 CR605626 BM720230 BX281242 CA414383 
    CA415325 BI830160 D37965 CD244937 BF667099 AI354720 F29871 AA461374 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDGFRL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAACAAT
    PDGFRL Expression
    About this image


    PDGFRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Bone (Muscoskeletal System)
             Rib
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Thyroid (Endocrine System)
    PDGFRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDGFRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458573

    UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198
    Tissue specificity: Expressed in colon, lung and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including PDGFRL: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PDGFRL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdgfrl1 , 5 platelet-derived growth factor receptor-like1, 5 84.09(n)1
    89.33(a)1
      8 (23.89 cM)5
    687971  NM_026840.31  NP_081116.31 
     409262125 
    chicken
    (Gallus gallus)
    Aves PDGFRL1 platelet-derived growth factor receptor-like 69.7(n)
    68.45(a)
      769077  XM_001231867.3  XP_001231868.2 
    lizard
    (Anolis carolinensis)
    Reptilia PDGFRL6
    platelet-derived growth factor receptor-like
    72(a)
    1 ↔ 1
    5(108948124-108981998)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237032 Xenopus laevis transcribed sequence with moderate similarity more 77.66(n)    CB562090.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561042 similar to platelet-derived growth factor receptor-like 73.72(n)   393284  BC062835.1 


    ENSEMBL Gene Tree for PDGFRL (if available)
    TreeFam Gene Tree for PDGFRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDGFRL (see all 2677)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0260524
    Colorectal cancer (CRC)4--see VAR_0260522 H Y mis40--------
    rs347065841,2
    C,F--17431971(+) GAAAAG/TTGGGT 1 -- us2k17Minor allele frequency- T:0.13NA CSA WA EA 365
    rs1492778911,2
    --17431982(+) GTTACA/GGGTAA 1 -- us2k10--------
    rs3690804361,2
    C--17432094(+) AAAAA-/ATCAGG 1 -- us2k10--------
    rs27050541,2
    C,F,A--17432104(-) TTTCCG/CAAGGC 1 -- us2k16Minor allele frequency- C:0.24WA NA EA 364
    rs767902961,2
    C,F--17432141(+) GAGCTG/TCAAGA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs25881691,2
    C,F,A--17432152(-) AATAAG/ACATTA 1 -- us2k16Minor allele frequency- A:0.26WA NA EA 364
    rs27050531,2
    C,A--17432189(-) TCCTTT/CTCCAA 1 -- us2k1 trp35Minor allele frequency- C:0.25WA NA EA 362
    rs1445107461,2
    C--17432212(+) AACACG/TACATT 1 -- us2k10--------
    rs735624481,2
    C,F--17432268(+) TTTTAT/CAGTGA 1 -- us2k12Minor allele frequency- C:0.06WA 120

    HapMap Linkage Disequilibrium report for PDGFRL (17433942 - 17501580 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDGFRL (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676506CNV Deletion23128226
    esv989082CNV Deletion20482838
    esv2670212CNV Deletion23128226
    nsv818612CNV Loss17921354
    nsv8306CNV Loss18304495
    esv34867CNV Loss17911159
    nsv516988CNV Loss19592680
    nsv824559CNV Loss20364138
    nsv890558CNV Loss21882294
    nsv831246CNV Gain17160897

    Human Gene Mutation Database (HGMD): PDGFRL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDGFRL
    DNA2.0 Custom Variant and Variant Library Synthesis for PDGFRL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604584   
    OMIM disorders: 114550  114500  
    UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry is involved in disease pathogenesis
  • Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease
    (PubMed:19815557). Behcet disease is a complex multiple-system disorder characterized by recurrent oral
    ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves
    joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract

  • 7 diseases for PDGFRL:    
    About MalaCards
    hepatocellular carcinoma, somatic    colonic adenoma recurrence, reduced risk of    colon cancer    colon cancer, somatic
    colorectal cancer    colorectal cancer, somatic    prostate cancer


    Find genes that share disorders with PDGFRL           About GenesLikeMe

    4 Novoseek inferred disease relationships for PDGFRL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 20.6 4 9197531 (2), 7898930 (1), 10362129 (1)
    prostate cancer 17.8 3 9197531 (3)
    cancer 12.3 1 19882270 (1)
    metastasis 0.842 1 19343157 (1)

    Genetic Association Database (GAD): PDGFRL
    Human Genome Epidemiology (HuGE) Navigator: PDGFRL (1 document)

    Export disorders for PDGFRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDGFRL gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with PDGFRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a candidate tumor suppressor gene on chromosome 8p21.3- p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. (PubMed id 7898930)1, 2, 9 Fujiwara Y....Nakamura Y. (Oncogene 1995)
    2. Genetic variant on PDGFRL associated with Behcet disease in Chinese Han populations. (PubMed id 22926996)1, 2 Hou S.... Yang P. (Hum. Mutat. 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Expression and functional characterization of platelet-derived growth factor receptor-like gene. (PubMed id 20333786)1, 9 Guo F.J....Li G.C. (World J. Gastroenterol. 2010)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    6. Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. (PubMed id 19815557)2 Pao-Chun L.... Manser E. (J. Biol. Chem. 2009)
    7. An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer. (PubMed id 18366601)1 Xu M....Zhou X.J. (BMC Genomics 2008)
    8. The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. (PubMed id 18442402)1 Riker A.I....Matta J. (BMC Med Genomics 2008)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression. (PubMed id 16552773)1 Seitz S....Scherneck S. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5157 HGNC: 8805 AceView: PDGFRL Ensembl:ENSG00000104213 euGenes: HUgn5157
    ECgene: PDGFRL H-InvDB: PDGFRL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PDGFRL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFRL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDGFRL gene:
    Search GeneIP for patents involving PDGFRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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