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Aliases for PDGFRL Gene

Aliases for PDGFRL Gene

  • Platelet Derived Growth Factor Receptor Like 2 3 5
  • PDGF Receptor Beta-Like Tumor Suppressor 3 4
  • PDGFR-Like Protein 3 4
  • PRLTS 3 4
  • Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor 3
  • Platelet-Derived Growth Factor Receptor-Like Protein 3
  • Platelet-Derived Growth Factor Receptor-Like 2
  • PDGRL 3

External Ids for PDGFRL Gene

Previous GeneCards Identifiers for PDGFRL Gene

  • GC08P017327
  • GC08P017514
  • GC08P017444
  • GC08P017478
  • GC08P017435
  • GC08P017436
  • GC08P015978

Summaries for PDGFRL Gene

Entrez Gene Summary for PDGFRL Gene

  • This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDGFRL Gene

PDGFRL (Platelet Derived Growth Factor Receptor Like) is a Protein Coding gene. Diseases associated with PDGFRL include Colorectal Cancer and Hepatocellular Carcinoma. GO annotations related to this gene include platelet activating factor receptor activity and platelet-derived growth factor beta-receptor activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFRL Gene

Genomics for PDGFRL Gene

Regulatory Elements for PDGFRL Gene

Enhancers for PDGFRL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F017596 0.2 ENCODE 21.9 +20.3 20300 1.4 CTCF BHLHE40 CEBPB HNF4G FOS ATF2 NFE2L2 PDGFRL ENSG00000253168 ENSG00000277466 MIR548V
GH08F017602 1.1 Ensembl ENCODE 18.7 +26.4 26384 1.3 ELF3 ARID4B ZNF2 RAD21 RARA MIXL1 ZNF680 ZNF654 CEBPB REST PDGFRL MTUS1 ENSG00000277466 MIR548V
GH08F017613 0.9 Ensembl ENCODE 17.2 +40.4 40372 7.6 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF143 SP3 SP5 ZHX2 PDGFRL MICU3 LOC105379298 LOC100133073 MTUS1 FGF20 ENSG00000277466 MIR548V
GH08F017538 0.6 ENCODE 17 -36.3 -36285 2.8 PKNOX1 INSM2 ZNF76 KLF17 FEZF1 RAD21 ZNF2 YY1 ZNF366 SCRT2 PDGFRL GC08P017569 ENSG00000279932
GH08F017694 0.7 ENCODE 16.6 +119.9 119865 3.8 MAX ZIC2 RAD21 CBX5 POLR2A FOXP2 ETV6 MAFK PDGFRL MTUS1 GC08M017697 MIR548V
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PDGFRL on UCSC Golden Path with GeneCards custom track

Promoters for PDGFRL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001386718 768 2000 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 SP3 SP5 KAT8 MIER3

Genomic Location for PDGFRL Gene

17,576,433 bp from pter
17,644,071 bp from pter
67,639 bases
Plus strand

Genomic View for PDGFRL Gene

Genes around PDGFRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDGFRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDGFRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFRL Gene

Proteins for PDGFRL Gene

  • Protein details for PDGFRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Platelet-derived growth factor receptor-like protein
    Protein Accession:
    Secondary Accessions:
    • A8K085
    • Q6FH04

    Protein attributes for PDGFRL Gene

    375 amino acids
    Molecular mass:
    41861 Da
    Quaternary structure:
    • Forms a complex composed of PDGFRL, TNK2 and GRB2.

neXtProt entry for PDGFRL Gene

Post-translational modifications for PDGFRL Gene

  • Glycosylation at Asn 132 and Asn 219
  • Modification sites at PhosphoSitePlus

Other Protein References for PDGFRL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PDGFRL
  • Santa Cruz Biotechnology (SCBT) Antibodies for PDGFRL

No data available for DME Specific Peptides for PDGFRL Gene

Domains & Families for PDGFRL Gene

Protein Domains for PDGFRL Gene

Suggested Antigen Peptide Sequences for PDGFRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PDGFRL: view

Function for PDGFRL Gene

Molecular function for PDGFRL Gene

GENATLAS Biochemistry:
platelet-derived growth factor receptor-like

Gene Ontology (GO) - Molecular Function for PDGFRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004992 platelet activating factor receptor activity TAS 7898930
GO:0005019 platelet-derived growth factor beta-receptor activity TAS 7898930
genes like me logo Genes that share ontologies with PDGFRL: view
genes like me logo Genes that share phenotypes with PDGFRL: view

Human Phenotype Ontology for PDGFRL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for PDGFRL

miRNA for PDGFRL Gene

miRTarBase miRNAs that target PDGFRL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PDGFRL Gene

Localization for PDGFRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFRL Gene


Subcellular locations from

Jensen Localization Image for PDGFRL Gene COMPARTMENTS Subcellular localization image for PDGFRL gene
Compartment Confidence
extracellular 4
plasma membrane 3
golgi apparatus 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PDGFRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PDGFRL: view

Pathways & Interactions for PDGFRL Gene

SuperPathways for PDGFRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDGFRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway IEA --
genes like me logo Genes that share ontologies with PDGFRL: view

No data available for Pathways by source and SIGNOR curated interactions for PDGFRL Gene

Drugs & Compounds for PDGFRL Gene

(2) Drugs for PDGFRL Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crenolanib (CP-868596) Pharma PDGFR-β inhibitor,potent and selective 0

(1) ApexBio Compounds for PDGFRL Gene

Compound Action Cas Number
Crenolanib (CP-868596) PDGFR-β inhibitor,potent and selective 670220-88-9
genes like me logo Genes that share compounds with PDGFRL: view

Transcripts for PDGFRL Gene


Unigene Clusters for PDGFRL Gene

Platelet-derived growth factor receptor-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRL Gene

No ASD Table

Relevant External Links for PDGFRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDGFRL Gene

mRNA expression in normal human tissues for PDGFRL Gene

mRNA differential expression in normal tissues according to GTEx for PDGFRL Gene

This gene is overexpressed in Nerve - Tibial (x6.4).

Protein differential expression in normal tissues from HIPED for PDGFRL Gene

This gene is overexpressed in Synovial fluid (47.9) and Placenta (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFRL Gene

Protein tissue co-expression partners for PDGFRL Gene

NURSA nuclear receptor signaling pathways regulating expression of PDGFRL Gene:


SOURCE GeneReport for Unigene cluster for PDGFRL Gene:


mRNA Expression by UniProt/SwissProt for PDGFRL Gene:

Tissue specificity: Expressed in colon, lung and liver.
genes like me logo Genes that share expression patterns with PDGFRL: view

Primer Products

Orthologs for PDGFRL Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFRL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDGFRL 34 35
  • 98.93 (n)
(Canis familiaris)
Mammalia PDGFRL 34 35
  • 87.56 (n)
(Bos Taurus)
Mammalia PDGFRL 34 35
  • 86.04 (n)
(Mus musculus)
Mammalia Pdgfrl 34 16 35
  • 84.09 (n)
(Rattus norvegicus)
Mammalia Pdgfrl 34
  • 84.09 (n)
(Monodelphis domestica)
Mammalia PDGFRL 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PDGFRL 35
  • 63 (a)
(Gallus gallus)
Aves PDGFRL 34 35
  • 69.7 (n)
(Anolis carolinensis)
Reptilia PDGFRL 35
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfrl 34
  • 70.8 (n)
Str.8504 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23703 34
(Danio rerio)
Actinopterygii pdgfrl 34 35
  • 61.75 (n)
zgc56104 34
Species where no ortholog for PDGFRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDGFRL Gene

Gene Tree for PDGFRL (if available)
Gene Tree for PDGFRL (if available)

Paralogs for PDGFRL Gene

No data available for Paralogs for PDGFRL Gene

Variants for PDGFRL Gene

Sequence variations from dbSNP and Humsavar for PDGFRL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs137853148 Colorectal cancer (CRC) [MIM:114500], Pathogenic 17,589,479(+) GCCAA(C/T)ACCTT reference, missense
rs10087384 -- 17,627,829(+) ACTAT(A/G)TATTA intron-variant
rs10088661 -- 17,635,222(+) gattt(C/T)ggtgt intron-variant
rs10088855 -- 17,624,634(+) gggtg(C/T)agtgg intron-variant
rs10090766 -- 17,628,101(+) ccatt(C/T)tcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDGFRL Gene

Variant ID Type Subtype PubMed ID
esv2670212 CNV deletion 23128226
esv2676506 CNV deletion 23128226
esv2759600 CNV loss 17122850
esv2761191 CNV loss 21179565
esv2764066 CNV gain+loss 21179565
esv34867 CNV loss 17911159
esv3616489 CNV loss 21293372
esv3616490 CNV loss 21293372
esv3616491 CNV loss 21293372
esv3616492 CNV loss 21293372
esv3616493 CNV loss 21293372
esv3891363 CNV loss 25118596
esv3891364 CNV gain 25118596
esv989082 CNV deletion 20482838
nsv516779 CNV gain+loss 19592680
nsv516988 CNV loss 19592680
nsv818612 CNV loss 17921354
nsv824559 CNV loss 20364138
nsv8306 CNV loss 18304495
nsv831246 CNV gain 17160897
nsv831247 CNV gain 17160897

Variation tolerance for PDGFRL Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDGFRL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFRL Gene

Disorders for PDGFRL Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDGFRL Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
perrault syndrome
  • gonadal dysgenesis, xx type
- elite association - COSMIC cancer census association via MalaCards


  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:7898930}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Note=A polymorphism in PDGFRL has been reported to be associated with susceptibility to Behcet disease (PubMed:22926996). Behcet disease is a complex multiple-system disorder characterized by recurrent oral ulcerations, recurrent genital ulcerations, typical skin lesions, and uveitis. Behcet disease also involves joints, blood vessels, musculoskeletal, neurological systems, and the gastrointestinal tract. {ECO:0000269 PubMed:22926996}.

Relevant External Links for PDGFRL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PDGFRL: view

No data available for Genatlas for PDGFRL Gene

Publications for PDGFRL Gene

  1. Isolation of a candidate tumor suppressor gene on chromosome 8p21.3- p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. (PMID: 7898930) Fujiwara Y. … Nakamura Y. (Oncogene 1995) 3 4 22 64
  2. Genetic variant on PDGFRL associated with Behcet disease in Chinese Han populations. (PMID: 22926996) Hou S. … Yang P. (Hum. Mutat. 2013) 3 4 64
  3. Expression and functional characterization of platelet-derived growth factor receptor-like gene. (PMID: 20333786) Guo F.J. … Li G.C. (World J. Gastroenterol. 2010) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts. (PMID: 23944365) Gialeli C. … Karamanos N.K. (Curr. Pharm. Des. 2014) 3 64

Products for PDGFRL Gene

Sources for PDGFRL Gene

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