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Aliases & Descriptions for PDGFRL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000161390 2 | | PDGRL 2, 5 | | PRLTS 1, 2, 3, 5 |
| | | Descriptions |
|---|
| PDGF receptor beta-like tumor suppressor 3 | | platelet-derived growth factor receptor-like 2 | | platelet-derived growth factor receptor-like protein 2 | | platelet-derived growth factor-beta-like tumor suppressor 2 |
|
| | Search outside databases for aliases for PDGFRL genePrevious GC identifers: GC08P017327 GC08P017514 GC08P017444 |
Summaries for PDGFRL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PDGFRL: This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq]
|
Genomic Location for PDGFRL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PDGFRL gene 
Entrez Gene cytogenetic band: 8p22-p21.3 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22-p21.3PDGFRL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P017478:
(about GC identifiers)
Start:
|
17,478,443 bp from pter |
End:
|
17,545,655 bp from pter |
Size:
|
67,213 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_030737.9
| Proteins for PDGFRL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198 (See
protein sequence)Recommended Name: Platelet-derived growth factor receptor-like protein precursor Size: 375 amino acids; 41861 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q6FH04Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006198.1
ENSEMBL proteins: ENSP00000251630 ENSP00000381149
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for PDGFRL: Assays for PDGFRL: | Protein
Domains/ Families for PDGFRL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15198
ProtoNet protein and cluster: Q15198 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains | Gene Function for PDGFRL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006207
Applied Biosystems Silencer® siRNAs for PDGFRL
Sigma-Aldrich siRNA and siRNA Panels for PDGFRL  Sigma-Aldrich shRNA Panels and shRNA for PDGFRL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006207                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006207                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006207 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006207
Genatlas biochemistry entry for PDGFRL:platelet-derived growth factor receptor-like2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004992 | platelet activating factor receptor activity |
TAS | 7898930 | | GO:0005019 | platelet-derived growth factor beta-receptor activity |
TAS | 7898930 | About this table | Pathways & Interactions for PDGFRL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for PDGFRL (ENSP000002516303) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for PDGFRL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for PDGFRL |
Browse Tocris compounds for PDGFRL 1 Novoseek chemical compound relationship for PDGFRL gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
11.93 |
2 |
1717981 (1), 9476070 (1) |
About this table
|
Transcripts for PDGFRL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006207
Sigma-Aldrich siRNA and siRNA Panels for PDGFRL  Sigma-Aldrich shRNA Panels and shRNA for PDGFRL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006207 REFSEQ mRNAs for PDGFRL gene: NM_006207.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006207               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006207                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006207                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006207  Additional cDNA sequence: AK289450.1 BC010927.1 CR541952.1 CR596869.1 CR605626.1 D37965.1 4 DOTS entries: DT.100700736 DT.440990 DT.121480841 DT.451623 24/106 AceView cDNA sequences (see all 106
):BQ575319 CR605626 BQ014860 BI754977 CR596869 AI264744 CB268406 BU624775 BM720230 BX281242 BM671983 AA461197 AA347805 D62559 BQ010346 AI750669 BI830160 AI354720 BX409923 BC010927 BE931604 BQ130306 BF667099 BX412183
highest scoring ESTs for PDGFRL:D37965 AA232627 AA232715 AA347805 AA454868 AA461197 AA461374 AA804673 AI129294 AI144466 Unigene Cluster for PDGFRL: Platelet-derived growth factor receptor-like Hs.458573 [show with all ESTs]Unigene Representative Sequence: AK289450
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000251630
ENST00000398074
|
Expression for PDGFRL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PDGFRL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PDGFRL
1 / 2 / 3 3 probe-sets matching PDGFRL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTAAACAAT
SOURCE GeneReport for Unigene cluster: Hs.458573
Expression variation in blood from EXPOLDB for PDGFRL UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198Tissue specificity: Expressed in colon, lung and liver |
Orthologs for PDGFRL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PDGFRL gene from 5/9 species (see all 9
)
About this table Species with no ortholog for PDGFRL
ENSEMBL Gene Tree for PDGFRL | Paralogs for PDGFRL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for PDGFRL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PDGFRL (up to first 250kb)
|
Disorders & Mutations for PDGFRL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604584 disorders: 114550 114500 UniProtKB/Swiss-Prot: PGFRL_HUMAN, Q15198
Defects in PDGFRL are associated with colorectal cancer (CRC) [MIM:114500]3 Novoseek disease relationships for PDGFRL gene
About this table
|
Medical News for PDGFRL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PDGFRL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/24 PubMed articles for PDGFRL gene (see all 24
):- Isolation of a candidate tumor suppressor gene on chromosome 8p21.3- p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. (PubMed id 7898930)1, 3, 4 Fujiwara Y....Nakamura Y. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- A 3-Mb physical map of the chromosome region 8p21.3-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer. (PubMed id 7519877)3 Fujiwara Y....Kurimasa A. (1994)
- Changes in nerve growth factor receptor-like immunoreactivity in the spinal cord after ventral funiculus lesion in adult cats. (PubMed id 1313859)1 Risling M....Meier M. (1992)
- PRLTS gene alterations in human prostate cancer. (PubMed id 9197531)1 Komiya A....Ito H. (1997)
- Role for platelet-derived growth factor-like and epidermal growth factor-like signaling pathways in gastrulation and spiculogenesis in the Lytechinus sea urchin embryo. (PubMed id 8563028)1 Ramachandran R.K....Tomlinson C.R. (1995)
- Fgfrl1, a fibroblast growth factor receptor-like gene, is found in the cephalochordate Branchiostoma floridae but not in the urochordate Ciona intestinalis. (PubMed id 16887372)1 Beyeler M. and Trueb B. (2006)
- [Comparison of tumor suppressor gene deletion between squamous cell carcinoma and adenocarcinoma lung cancer in Chinese] (PubMed id 11859712)1 An Q....Huang J. (2001)
- Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer. (PubMed id 9103388)1 Ilekis J.V.... Scoccia B. (1997)
|
Search for PDGFRL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PDGFRL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PDGFRL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDGFRL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PDGFRL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PDGFRL:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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