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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDGFRB Gene

protein-coding   GIFtS: 76
GCID: GC05M149473

platelet-derived growth factor receptor, beta polypeptide


(Previous symbol: PDGFR)
 Explore 146 diseases affiliated with
PDGFRB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDGFRB    

Aliases
for PDGFRB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Platelet-Derived Growth Factor Receptor, Beta Polypeptide1 2     CD140 Antigen-Like Family Member B2 3
PDGFR1 2 3 5     EC 2.7.10.13 8
PDGFR11 2 3     CD140b1
JTK121 2     CD140B2
Beta-Type Platelet-Derived Growth Factor Receptor2 3     IBGC42
Platelet-Derived Growth Factor Receptor 12 3     Platelet-Derived Growth Factor Receptor Beta2
PDGF-R-Beta1     Beta Platelet-Derived Growth Factor Receptor3
PDGFR-12 3     CD140b Antigen3
PDGFR-Beta1     EC 2.7.108

External Ids:    HGNC: 88041   Entrez Gene: 51592   Ensembl: ENSG000001137217   OMIM: 1734105   UniProtKB: P096193   

Export aliases for PDGFRB gene to outside databases

Previous GC identifers: GC05M149563 GC05M150021 GC05M149476 GC05M149521 GC05M144641


Summaries
for PDGFRB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDGFRB:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a
receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both
platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes
for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three
genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to
that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619
Function: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for
heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell
proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel
development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial
cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury
sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes
(mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney
glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its
cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the
activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by
the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1
and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of
PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling
pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the
activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation
and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is
down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid
internalization of the activated receptor

summary for PDGFRB:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFRB


Genomic Views
for PDGFRB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDGFRB gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDGFRB promoter sequence
   Search SABiosciences Chromatin IP Primers for PDGFRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

PDGFRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFRB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M149473:  view genomic region     (about GC identifiers)

Start:
 149,493,400 bp from pter      End:
 149,535,423 bp from pter
Size:
 42,024 bases      Orientation:
 minus strand

Proteins
for PDGFRB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619 (See protein sequence)
Recommended Name: Platelet-derived growth factor receptor beta precursor  
Size: 1106 amino acids; 123968 Da
Subunit: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB. May also interact
with homodimeric PDGFC. Monomer in the absence of bound ligand. Interaction with homodimeric PDGFB, heterodimers
formed by PDGFA and PDGFB or homodimeric PDGFD, leads to receptor dimerization, where both PDGFRA homodimers and
heterodimers with PDGFRB are observed. Interacts with SH2B2/APS. Interacts directly (tyrosine phosphorylated) with
SHB. Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine phosphorylated) with CBL. Interacts
(tyrosine phosphorylated) with SRC and SRC family kinases. Interacts (tyrosine phosphorylated) with PIK3C2B, maybe
indirectly. Interacts (tyrosine phosphorylated) with SHC1, GRB7, GRB10 and NCK1. Interaction with GRB2 is mediated by
SHC1. Interacts (via C-terminus) with SLC9A3R1
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen.
Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its
degradation
5 PDB 3D structures from and Proteopedia for PDGFRB:
1GQ5 (3D)        1H9O (3D)        1LWP (3D)        2L6W (3D)        3MJG (3D)    
Secondary accessions: Q8N5L4

Explore the universe of human proteins at neXtProt for PDGFRB: NX_P09619

Post-translational modifications:

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of
    • the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-579, and to a
    lesser degree, at Tyr-581, is important for interaction with SRC family kinases. Phosphorylation at Tyr-740 and
    Tyr-751 is important for interaction with PIK3R1. Phosphorylation at Tyr-751 is important for interaction with NCK1.
    Phosphorylation at Tyr-771 and Tyr-857 is important for interaction with RASA1/GAP. Phosphorylation at Tyr-857 is
    important for efficient phosphorylation of PLCG1 and PTPN11, resulting in increased phosphorylation of AKT1,
    MAPK1/ERK2 and/or MAPK3/ERK1, PDCD6IP/ALIX and STAM, and in increased cell proliferation. Phosphorylation at Tyr-1009
    is important for interaction with PTPN11. Phosphorylation at Tyr-1009 and Tyr-1021 is important for interaction with
    PLCG1. Phosphorylation at Tyr-1021 is important for interaction with CBL; PLCG1 and CBL compete for the same binding
    site. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-10211
  • N-glycosylated1
  • Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09619

    • 4/21 DME Specific Peptides for PDGFRB (P09619) (see all 21)
     RDLAARN  LGGTPYP  ALMSELK  PAHASDE 

    PDGFRB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002600.1  
    ENSEMBL proteins: 
     ENSP00000261799   ENSP00000430026   ENSP00000429218   ENSP00000430715  
    Reactome Protein details: P09619
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PDGFRB Protein
    R&D Systems Recombinant & Natural Proteins for PDGFRB (PDGF R beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PDGFRB
    OriGene Protein Over-expression Lysate: PDGFRB
    OriGene Custom Protein Services for PDGFRB 
    GenScript Custom Purified and Recombinant Proteins Services for PDGFRB
    Novus Biologicals PDGFRB Proteins
    Novus Biologicals PDGFRB Lysates
    Sino Biological Recombinant Protein for PDGFRB
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane IDA16477012


    PDGFRB for ontologies           About GeneDecksing



    PDGFRB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFRB
    R&D Systems Antibodies for PDGFRB (PDGF R beta)
    Cell Signaling Technology (CST) Antibodies for PDGFRB 
    OriGene Antibodies (see all 9): PDGFRB
    OriGene Custom Antibody Services for PDGFRB 
    GenScript Custom Superior Antibodies Services for PDGFRB
    Novus Biologicals PDGFRB Antibodies
    Abcam antibodies for PDGFRB 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for PDGFRB

    Assay Products for PDGFRB: 
    EMD Millipore Kits and Assays for the Analysis of PDGFRB
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for PDGFRB (PDGF R beta)         (see all)
    GenScript Custom Assay Services for PDGFRB
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PDGFRB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PDGFRB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDGFRB for domains           About GeneDecksing

    5/15 InterPro domains/families (see all 15):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR009134 Tyr_kinase_VEGFR_rcpt_N

    Graphical View of Domain Structure for InterPro Entry P09619

    ProtoNet protein and cluster: P09619

    4 Blocks protein families:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature


    UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Function
    for PDGFRB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619
    Function: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for
    heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell
    proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel
    development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial
    cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury
    sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes
    (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney
    glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its
    cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the
    activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by
    the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1
    and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
    1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of
    PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling
    pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the
    activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation
    and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is
    down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid
    internalization of the activated receptor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD
    leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib

         Genatlas biochemistry entry for PDGFRB:
    platelet-derived growth factor receptor,beta,subunit,homodimerizing and heterodimerizing with PDGFRA,immunoglobulin
    superfamily type III RTK subfamily,constitutively activated through amino-acid(s) substitution in a WW-like domain
    (phosphoserine- or phosphothreonine binding)

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target PDGFRB:
    hsa-mir-224 (MIRT000770)

    OriGene 3'-UTR Clone: PDGFRB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFRB
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFRB (see all 36):
    hsa-miR-3194-5p hsa-miR-3655 hsa-miR-548k hsa-miR-29a hsa-miR-30d hsa-miR-486-3p hsa-miR-578 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: PDGFRB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFRB (see all 7)
    OriGene shRNA RFP: PDGFRB
    OriGene siRNA: PDGFRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFRB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDGFRB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRB (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PDGFRB (NM_002609)
    Sino Biological Human cDNA Clone for PDGFRB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PDGFRB
    Search LifeMap BioReagents cell lines for PDGFRB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRB

    Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity IDA1653029
    GO:0004871signal transducer activity ----
    GO:0004992platelet activating factor receptor activity TAS2536956
    GO:0005017platelet-derived growth factor-activated receptor activity TAS2536956
    GO:0005019platelet-derived growth factor beta-receptor activity IMP2554309


    PDGFRB for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PDGFRB:
     Decreased focal adhesion (FA)   Decreased viability with RAF26  Increased cell death HMECs cel  Increased cell death in breast 
     Increased mitotic index 

    Animal Models:
         Mouse knock-outs for PDGFRB: Pdgfrbtm10Sor Pdgfrbtm1Sor
         15/20 MGI mutant phenotypes (inferred from 18 alleles) (MGI details for Pdgfrb) (see all 20):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 

    PDGFRB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDGFRB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/51 super-pathways (see all 51) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/13 pathways (see all 13)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    4GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for PDGFRB (see all 6)
        Transcription PPAR Pathway
    Development PDGF signaling via MAPK cascades
    Development PDGF signaling via STATs and NF-kB
    Signal transduction IP3 signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration

    5/58 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDGFRB (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for PDGFRB
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for PDGFRB
        Akt Pathway
    Apoptosis Pathway

    5/7 GeneGo (Thomson Reuters) Pathways for PDGFRB (see all 7)
        G-protein signaling H-RAS regulation pathway
    Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Transcription PPAR Pathway
    Development PDGF signaling via MAPK cascades

    5/12 BioSystems Pathways for PDGFRB (see all 12) 
        Signaling Pathways in Glioblastoma
    Focal Adhesion
    MAPK signaling pathway
    Regulation of Actin Cytoskeleton
    Osteoblast Signaling

    5/30        Reactome Pathways for PDGFRB (see all 30)
        Signaling by EGFR in Cancer
    Disease
    Signaling by ERBB2
    GAB1 signalosome
    PI3K/AKT activation

    2 PharmGKB Pathways for PDGFRB
        Sorafenib Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    5/10         Kegg Pathways  (Kegg details for PDGFRB) (see all 10):
        MAPK signaling pathway
    Calcium signaling pathway
    Cytokine-cytokine receptor interaction
    Focal adhesion
    Gap junction


    PDGFRB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDGFRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/191 Interacting proteins for PDGFRB (P096191, 2, 3 ENSP000002617994) via UniProtKB, MINT, STRING, and/or I2D (see all 191)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8029783 MINT-8029948 MINT-8029933 MINT-8029858 MINT-8030936 MINT-8031128 MINT-8029888 MINT-8031173 MINT-8029798 MINT-8030966 MINT-8030997 MINT-8031204 MINT-8029963 MINT-8030981 MINT-8031012 MINT-8031113 MINT-8031053 MINT-8031143 I2D: score=6 STRING: ENSP00000274335
    PTPN12Q052091, 2, 3, ENSP000002485944EBI-641237,EBI-2266035 MINT-8312127 I2D: score=1 STRING: ENSP00000248594
    PTPN11Q061242, 3, ENSP000003409444MINT-8027706 MINT-8312073 MINT-8034408 MINT-8312088 MINT-8027690 MINT-8027737 MINT-8027752 I2D: score=6 STRING: ENSP00000340944
    PLCG1P191742, 3, ENSP000002440074MINT-8034363 MINT-8034483 MINT-8027675 MINT-8034498 I2D: score=5 STRING: ENSP00000244007
    GRB7Q144512, 3, ENSP000003107714MINT-8035557 MINT-8035572 MINT-8037827 MINT-8037842 I2D: score=3 STRING: ENSP00000310771
    About this table

    Gene Ontology (GO): 5/62 biological process terms (GO ID links to tree view) (see all 62):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001822kidney development ----
    GO:0001894tissue homeostasis IEA--
    GO:0006024glycosaminoglycan biosynthetic process IEA--
    GO:0006807nitrogen compound metabolic process ----


    PDGFRB for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDGFRB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDGFRB for compounds           About GeneDecksing

    EMD Millipore small molecules for PDGFRB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDGFRB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    AG 18EGFR/PDGFR-kinase inhibitor[118409-57-7]
    SU 16fPotent and selective PDGFRbeta inhibitor[251356-45-3]

    2 HMDB Compounds for PDGFRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    5 DrugBank Compounds for PDGFRB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ImatinibImatinib Mesylate (see all 3)152459-95-5targetantagonist15803362 15753388 15887238 15893416 15794712
    SunitinibSU11248 (see all 3)557795-19-4targetantagonist16425993 12538485 15557593 12748309 14753710
    Dasatinib-- 302962-49-8targetantagonist16436588 16497876 20072833
    Sorafenib-- 284461-73-0targetantagonist17545544 16425993 17619763
    Becaplerminc-sis (see all 5)165101-51-9target--18686746

    10/76 Novoseek chemical compound relationships for PDGFRB gene (see all 76)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 93.2 396 19041155 (5), 14760091 (4), 12644539 (4), 17545544 (3) (see all 99)
    tyrosine 87.5 491 7678051 (5), 10760511 (4), 7688466 (3), 9920285 (3) (see all 99)
    ag-1296 87.4 19 17299794 (2), 17158602 (1), 17699781 (1), 18571505 (1) (see all 15)
    sunitinib 81.7 35 19366796 (3), 17367763 (2), 17327610 (2), 19754358 (2) (see all 26)
    su6668 79.8 17 11978732 (3), 15701856 (2), 16144927 (1), 12888313 (1) (see all 9)
    sorafenib 73.2 42 17545544 (6), 17229632 (3), 17178882 (2), 16757355 (2) (see all 26)
    vegf 67.6 78 10691304 (4), 17611402 (3), 9705159 (3), 19082496 (3) (see all 36)
    phosphatidylinositol 64.4 51 7689724 (3), 10318871 (2), 1702511 (1), 19584297 (1) (see all 36)
    dasatinib 63 8 19602594 (2), 18524994 (1), 19363859 (1), 20406945 (1) (see all 7)
    phosphotyrosine 60.1 13 7689724 (2), 12149261 (2), 1375321 (1), 12822894 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about PDGFRB / PGFRB 

    Transcripts
    for PDGFRB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDGFRB gene: 
    NM_002609.3  

    Unigene Cluster for PDGFRB:

    Platelet-derived growth factor receptor, beta polypeptide
    Hs.509067  [show with all ESTs]
    Unigene Representative Sequence: BC032224
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261799(uc003lro.3 uc010jhd.3) ENST00000520851 ENST00000520579(uc011dcg.1)
    ENST00000519575 ENST00000521723 ENST00000520229 ENST00000522466 ENST00000517488
    ENST00000517957

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PDGFRB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFRB
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFRB (see all 36):
    hsa-miR-3194-5p hsa-miR-3655 hsa-miR-548k hsa-miR-29a hsa-miR-30d hsa-miR-486-3p hsa-miR-578 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: PDGFRB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFRB (see all 7)
    OriGene shRNA RFP: PDGFRB
    OriGene siRNA: PDGFRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFRB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRB (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PDGFRB (NM_002609)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDGFRB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDGFRB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDGFRB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFRB

    Additional cDNA sequence: 

    AB209657.1 AK293093.1 BC032224.1 EU826595.1 J03278.1 JN003579.1 M21616.1 M30493.1 

    17 DOTS entries:

    DT.120845737  DT.448552  DT.40132860  DT.120845610  DT.100775478  DT.95276859  DT.97767661  DT.100028310 
    DT.102828348  DT.95225962  DT.100775476  DT.120845517  DT.120845711  DT.95279873  DT.91661119  DT.92015635 
    DT.92034934 

    24/463 AceView cDNA sequences (see all 463):

    CA307730 BQ723697 AA359391 BC032224 AI590783 BP360429 AA402994 R70545 
    BM702001 NM_005211 CN481180 BM677026 BQ710007 BM689263 T51882 CN481362 
    CN483678 CD366480 CN483583 BU069568 CD518518 M14193 CD369943 AA368051 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRB (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
    SP1:                    -     -     -     -                                                                             -                                   -   
    SP2:                    -     -     -     -                             -                                               -                                   -   
    SP3:                                                                                                                                                            
    SP4:                                      -                                                                                                                     
    SP5:                    -     -     -     -     -                                                                                                               

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:        -     -                                                         
    SP2:        -     -                                                         
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for PDGFRB

    Expression
    for PDGFRB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDGFRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGTATGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PDGFRB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/22 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 22) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVascular AdiposeAdipose Mural CellsAdipose
    BrainBlood Brain BarrierPericytesPericytes
    EndotheliumMicrovesselsPericytesPericytes
    Lateral Plate MesodermSplanchnic MesodermPericytesPericytes
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)MorulaMorula CellsEarly Embryo
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    Extraembryonic MesodermExtraembryonic MesodermExtraembryonic Mural CellsExtraembryonic Tissues
    Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeSmooth Muscle CellsNeural Crest, Smooth Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    Mouse ureteric bud cells (CMUB-1) (Cell line)Kidney
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    GABA neuron-like cells (Generation of motor ...)Brain
    Chondrocyte-like cells (Direct differentiati...)Bone, Cartilage
    Mesoderm-like cells (Direct differentiati...)Mesoderm
    Paraxial mesoderm-derived smooth muscle cells (Generation of human ...)

    See PDGFRB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDGFRB

    SOURCE GeneReport for Unigene cluster: Hs.509067
        SABiosciences Expression via Pathway-Focused PCR Arrays including PDGFRB (see all 7): 
              Notch Signaling Targets in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cancer Drug Targets in human mouse rat
              Atherosclerosis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDGFRB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDGFRB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDGFRB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFRB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRB

    Orthologs
    for PDGFRB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PDGFRB gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PDGFRB1 platelet-derived growth factor receptor, beta polypeptide 70.05(n)
    68.11(a)    		   770488  XM_001233829.2  XP_001233830.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDGFRB6
    		 --
    		 61(a)
    		 1 ↔ 1
    		 2(139518036-139556552)
    zebrafish
    (Danio rerio)    		 Actinopterygii pdgfrb1 platelet-derived growth factor receptor beta 58(n)
    52.29(a)    		   559529  NM_001190933.1  NP_001177862.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG32773 protein amino acid phosphorylation protein
    tyrosine more    		 33(a)
    (best of 2)    		   23E3   --


    ENSEMBL Gene Tree for PDGFRB (if available)
    TreeFam Gene Tree for PDGFRB (if available) 

    Paralogs
    for PDGFRB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDGFRB gene
    FLT42  FGFR42  CSF1R2  FGFR32  KIT2  PDGFRA2  RET2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    5 SIMAP similar genes for PDGFRB using alignment to 5 protein entries:     PGFRB_HUMAN (see all proteins):
    EPHA2    KIT    CSF1R    PDGFRA    CDK4

    PDGFRB for paralogs           About GeneDecksing



    Genomic Variants
    for PDGFRB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/947 NCBI SNPs in PDGFRB are shown (see all 947)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs117408401,2
    		C,F,H,--144646045(+) GTGCTC/GTAGGC 1 -- int17Minor allele frequency- G:0.07NS EA NA WA 660
    rs14328781,2
    		F,A,--144646216(+) ATCACG/ACAGAG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs785117601,2
    		--144646801(+) TGCTGG/TCCTGA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs786424721,2
    		C,--144647623(+) GGCTGG/TTGAAG 2 N T mis10--------
    rs412871061,2
    		C,--144647776(+) TCTCCG/ATCCCA 1 -- int13Minor allele frequency- A:0.02NA EA 242
    rs795664831,2
    		F,--144649302(+) CCTCAA/GTTTCT 1 -- int12Minor allele frequency- G:0.04WA NA 238
    rs1129862511,2
    		C--144649422(+) ACCCAG/CCAGAG 1 -- spd11Minor allele frequency- C:0.00CSA 1
    rs561129871,2
    		C--144649499(+) TTCATA/GTCCAG 2 D syn10--------
    rs784366281,2
    		C,F,--144649644(+) CCTGCC/TCCTTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs560773591,2
    		C--144649661(+) ATGAAC/TTTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PDGFRB (149493400 - 149535423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PDGFRB
         1 Indel: 12766

    5/19 SABiosciences Cancer Mutation PCR Assays for PDGFRB (see all 19):
    Cosmic IdAA Change
    40449p.V348V
    117293p.Y343S
    48648p.T545I
    119695p.L12V
    75895p.R849G
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing PDGFRB:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDGFRB
    DNA2.0 Custom Variant and Variant Library Synthesis for PDGFRB

    Disorders / Diseases
    for PDGFRB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDGFRB for disorders           About GeneDecksing

    OMIM gene information: 173410   
    OMIM disorders: 131440  
    UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619
  • Note=A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML).
    • Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by
    progression to acute myelogenous leukemia (AML)
  • Note=A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation
    • t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia
  • Note=A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia.
    • Translocation t(5;17)(q33;p11.2) with SPECC1
  • Defects in PDGFRB are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. A
    • hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving
    PDGFRB is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with
    ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein. Translocation t(5;15)(q33;q22) with TP53BP1 creating a
    PDGFRB-TP53BP1 fusion protein
  • Note=A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD)
    • associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein
  • Note=A chromosomal aberration involving PGFRB is found in a patient with T-lymphoblastic lymphoma (T-ALL) and
    • an associated myeloproliferative neoplasm (MPN) with eosinophilia. Translocation t(5;6)(q33-34;q23) with CEP85L. The
    translocation fuses the 5'-end of CEP85L (isoform 4) to the 3'-end of PDGFRB

    20/146 diseases for PDGFRB (see all 146):    About MalaCards
    myeloproliferative disorder with eosinophilia    myeloproliferative disorder    eosinophilia    von hippel-lindau disease
    desmoplastic small round cell tumor    malignant peripheral nerve sheath tumor    dermatofibrosarcoma protuberans    leukemia
    alveolar soft part sarcoma    pigmented villonodular synovitis    malignant fibrous histiocytoma    fibrous histiocytoma
    polycythemia vera    gastrointestinal stromal tumor    graft versus host disease    myelomonocytic leukemia
    hypereosinophilic syndrome    leydig cell tumor    eosinophilic myeloproliferative disorder    villonodular synovitis

    5 diseases from the University of Copenhagen DISEASES database for PDGFRB:
    Eosinophilia     Leukemia     Systemic mastocytosis     Myelofibrosis
    Pigmented villonodular synovitis

    10/94 Novoseek disease relationships for PDGFRB gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrointestinal stromal tumor 78.3 9 15224284 (1), 16294026 (1), 11914627 (1), 19366796 (1) (see all 9)
    myeloproliferative neoplasm 78 17 20107158 (3), 20085582 (2), 18971950 (1), 19006078 (1) (see all 8)
    hypereosinophilic syndrome 74.7 1 18706197 (1)
    leukemia myelomonocytic chronic 73.3 13 11588050 (2), 9616134 (1), 12908555 (1), 19100521 (1) (see all 11)
    leukemia eosinophilic 69.7 2 19761433 (1), 20053713 (1)
    dermatofibrosarcoma protuberans 68.6 4 17431412 (1), 15532894 (1), 15794712 (1)
    myeloid leukemia chronic 67.4 15 12480706 (1), 16143881 (1), 19509233 (1), 11914627 (1) (see all 15)
    myeloproliferative disorders 67.4 29 17296564 (3), 18262053 (2), 15477214 (2), 10910073 (1) (see all 19)
    tumors 64.6 302 20505768 (9), 16988946 (5), 15705896 (4), 12644539 (4) (see all 99)
    mastocytosis systemic 57.3 8 15995325 (1)

    Genetic Association Database (GAD): PDGFRB
    Human Genome Epidemiology (HuGE) Navigator: PDGFRB (14 documents)
    Tumor Gene Database (TGDB): PDGFRB

    Export disorders for PDGFRB gene to outside databases

    Publications
    for PDGFRB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDGFRB gene, integrated from 9 sources (see all 1019):
    (articles sorted by number of sources associating them with PDGFRB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Binding of Cbl to a phospholipase Cgamma1-docking sit e on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. (PubMed id 17620338)1, 2, 9 Reddi A.L....Band H. (2007)
    2. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PubMed id 9373237)1, 2, 9 Abe A....Saito H. (1997)
    3. Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms. (PubMed id 15380338)1, 4, 9 Bruck P....Ottmann O.G. (2004)
    4. Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. (PubMed id 10821867)1, 2, 9 Kovalenko M....Ostman A. (2000)
    5. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. (PubMed id 21938754)1, 2 Chmielecki J.... Pao W. (2012)
    6. A novel signaling axis of matriptase/PDGF-D/A9-PDGFR i n human prostate cancer. (PubMed id 21098708)1, 2 Ustach C.V....Kim H.R. (2010)
    7. Structures of a platelet-derived growth factor/propep tide complex and a platelet-derived growth factor/receptor complex. (PubMed id 20534510)1, 2 Shim A.H....He X. (2010)
    8. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. (PubMed id 15902258)1, 2 Choi M.H....Kang S.W. (2005)
    9. HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). (PubMed id 15087372)1, 2 Morerio C....Panarello C. (2004)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)

    External Searches for PDGFRB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing PDGFRB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5159 HGNC: 8804 AceView: PDGFRBandCSF1R Ensembl:ENSG00000113721 euGenes: HUgn5159
    ECgene: PDGFRB Kegg: 5159 H-InvDB: PDGFRB

    Other Databases showing PDGFRB gene

    (According to HUGE)
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    		   --

    Specialized Databases showing PDGFRB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDGFRB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFRB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PDGFRB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDGFRB gene:
    Search GeneIP for patents involving PDGFRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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    About This Section

     EMD Millipore Purified and/or Recombinant PDGFRB Protein
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
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