V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PDGFRB Gene

protein-coding GIFtS: 75

GC05M149473

platelet-derived growth factor receptor, beta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PDGFR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD140B ^²
CD140b ^¹
EC 2.7.10.1 ^³
JTK12 ^¹, ²
PDGF-R-beta ^², ³
PDGFR ^², ⁵
PDGFR1 ^¹, ²

Descriptions
CD140 antigen-like family member B ^², ³
CD140b antigen ^³
platelet-derived growth factor receptor beta ^²
platelet-derived growth factor receptor, beta polypeptide ^²
soluble PDGFRb variant 1 ^²

External Ids
HGNC: 8804¹
Entrez Gene: 5159²
UniProtKB: P09619³
Ensembl: ENSG00000113721⁷

Search outside databases for aliases for PDGFRB gene

Previous GC identifers: GC05M149563 GC05M150021 GC05M149476 GC05M149521

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PDGFRB:

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived

growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The

identity of the growth factor bound to a receptor monomer determines whether the functional

receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor

alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for

granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor

receptor; all three genes may be implicated in the 5-q syndrome. A translocation between

chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene,

results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq]

UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619

Function: Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase

activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the

SH2 domain of GRB2

Gene Wiki entry for PDGFRB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDGFRB gene

Entrez Gene cytogenetic band: 5q31-q32 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31-q32

PDGFRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M149473: (about GC identifiers)

Start:	149,473,595 bp from pter
End:	149,515,615 bp from pter
Size:	42,021 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619 (See protein sequence)

Recommended Name: Beta-type platelet-derived growth factor receptor precursor

Size: 1106 amino acids; 123968 Da

Subunit: Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form

interacts directly with SHB and with PIK3C2B, maybe indirectly

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1GQ5 (3D)

1H9O (3D)

1LWP (3D)

Secondary accessions: Q8N5L4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002600.1

ENSEMBL proteins:

ENSP00000261799

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PDGFRB
	Millipore Purified and/or Recombinant PDGFRB Protein
	Sigma-Aldrich Proteins for PDGFRB
	R&D Systems Recombinant & Natural Proteins for PDGFRB (PDGF R beta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PDGF Receptor alpha + beta, PDGF Receptor beta)
	Human Recombinant Proteins from Abnova (PDGFRB)

OriGene Purified Recombinant Human Protein: PDGFRB

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for PDGFRB:

	Invitrogen Antibodies for PDGFRB
	Millipore Mono- and Polyclonal Antibodies for the study of PDGFRB
	Sigma-Aldrich Antibody Arrays and Antibodies for PDGFRB
	R&D Systems Antibodies for PDGFRB (PDGF R beta)
	Cell Signaling Technology (CST) Antibodies for PDGFRB (PDGFR beta)
	Antibodies from Abcam (PDGF Receptor alpha + beta, PDGF Receptor beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDGFRB)
	Novus Biologicals Antibodies for PDGFRB

Assays for PDGFRB:

	Invitrogen Assays for PDGFRB
	Millipore Kits and Assays for the Analysis of PDGFRB
	R&D Systems ELISAs for PDGFRB (PDGF R beta) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for PDGFRB (PDGFR beta)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09619

ProtoNet protein and cluster: P09619

4 Blocks protein families:

IPB001824 Receptor tyrosine kinase

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

IPB009134 Vascular endothelial growth factor receptor signature

UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF

receptor subfamily

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDGFRB)
		Millipore RNAi Products for the Analysis of PDGFRB Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PDGFRB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002609

Applied Biosystems Silencer® siRNAs for PDGFRB

Sigma-Aldrich siRNA and siRNA Panels for PDGFRB

Sigma-Aldrich shRNA Panels and shRNA for PDGFRB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PDGFRB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002609
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002609
untagged cDNA clone in CMV expression vector: NM_002609

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002609

UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619

Function: Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase

activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the

SH2 domain of GRB2

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for PDGFRB:

platelet-derived growth factor receptor,beta,subunit,homodimerizing and heterodimerizing with

PDGFRA,immunoglobulin superfamily type III RTK subfamily,constitutively activated through

amino-acid(s) substitution in a WW-like domain (phosphoserine- or phosphothreonine binding)

15/20 MGI mutant phenotypes (inferred from 15 alleles) (MGI details for Pdgfrb) (see all 20 ):

	cellular	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	muscle	nervous system	normal

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004992	platelet activating factor receptor activity	TAS	2536956
GO:0005019	platelet-derived growth factor beta-receptor activity	IDA	2536956
GO:0005021	vascular endothelial growth factor receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for PDGFRB (Your Favorite Gene powered by Ingenuity) (see all 7 )

Glioma Signaling
PPAR Signaling
NF-&kappa
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Human Embryonic Stem Cell Pluripotency

GeneDecks PDGFRB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PDGFRB

5/167 Interacting proteins for PDGFRB (ENSP00000261799³ P09619^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 167 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDGFB	P01127¹	STRING (score=.999) EBI-641237, EBI-1554925
PIK3C2B	O00750¹	STRING (score=.812) EBI-641237, EBI-641107
PTPRJ	Q12913¹	STRING (score=.971) EBI-641237, EBI-2264500
SLC9A3R1	O14745²	STRING (score=.999) MINT-2832623 MINT-2833042
PTEN	P60484²	STRING (score=.992) MINT-2832984

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	2536956 10821867
GO:0008284	positive regulation of cell proliferation	IDA	17470632
GO:0030335	positive regulation of cell migration	IDA	17470632
GO:0046777	protein amino acid autophosphorylation	IDA	2536956
GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	2536956

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PDGFRB

Sigma-Aldrich Small Molecules for PDGFRB:

Inhibitor

Compounds for PDGFRB available from Tocris Bioscience

Compound	Action	CAS number
SU 6668	PDGFR, VEGFR and FGFR inhibitor	[252916-29-3]
AG 213	EGFR/PDGFR-kinase inhibitor	[122520-86-9]
DMPQ dihydrochloride	Potent, selective inhibitor of beta-type PDGFR	[137206-97-4]
AG 18	EGFR/PDGFR-kinase inhibitor	[118409-57-7]
SU 16f	Potent and selective PDGF-Rbeta inhibitor	[251356-45-3]

About this table

10/36 Novoseek chemical compound relationships for PDGFRB gene (see all 36 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ag-1296	87.73	16	17299794 (2), 17158602 (1), 17699781 (1), 18571505 (1) (see all 14)
tyrosine	87.18	452	7678051 (5), 10760511 (4), 7688466 (3), 9920285 (3) (see all 99)
su6668	79.33	16	11978732 (3), 15701856 (2), 16144927 (1), 19047154 (1) (see all 8)
phosphatidylinositol	64.65	48	7689724 (3), 10318871 (2), 1702511 (1), 9506992 (1) (see all 33)
phosphotyrosine	60.07	13	7689724 (2), 12149261 (2), 1375321 (1), 12822894 (1) (see all 7)
pki-166	54.52	2	15205332 (1)
wortmannin	42.23	11	17299794 (2), 10318871 (1), 9543391 (1), 8552594 (1) (see all 7)
phosphoinositide	34.44	3	11062076 (1), 18204097 (1)
zd6474	33.88	1	11881999 (1)
threonine	25.59	9	19228077 (1), 19188183 (1), 15134532 (1), 17098432 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDGFRB)
		Millipore RNAi Products for the Analysis of PDGFRB Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PDGFRB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002609

Sigma-Aldrich siRNA and siRNA Panels for PDGFRB

Sigma-Aldrich shRNA Panels and shRNA for PDGFRB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002609

REFSEQ mRNAs for PDGFRB gene:

NM_002609.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002609

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002609
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002609
                                 untagged cDNA clone in CMV expression vector: NM_002609

Additional cDNA sequence:

AB209657.1 AK293093.1 BC032224.1 CR593034.1 CR612121.1 EU826595.1 J03278.1 M21616.1

M30493.1

17 DOTS entries:

DT.120845737 DT.40132860 DT.448552 DT.120845610 DT.100775478 DT.95276859 DT.97767661 DT.100028310

DT.91661119 DT.92015635 DT.102828348 DT.95225962 DT.100775476 DT.120845517 DT.120845711 DT.92034934

DT.95279873

24/463 AceView cDNA sequences (see all 463 ):

BM704575 CD366480 CN481180 AW963369 CR612121 BQ709453 BX479433 CA307730

BF375451 CR613133 AA402994 BM689263 T51882 AA833737 BM702001 BX102016

AI749531 BF377002 AA368051 BP360429 BQ710007 CN481362 NM_005211 AI590783

highest scoring ESTs for PDGFRB:

J03278 AA852228 AL589565 AL596837 AU077268 AU100262 BC032224 BI554032 BM546285 BX504022

Unigene Cluster for PDGFRB:

Platelet-derived growth factor receptor, beta polypeptide

Hs.509067 [show with all ESTs]

Unigene Representative Sequence: BC032224

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRB (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^
SP1:							-		-		-		-																										-												-
SP2:							-		-		-		-										-																-												-
SP3:
SP4:													-
SP5:							-		-		-		-		-

ExUns:	17	^	18	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24	^	25	^	26a	·	26b
SP1:			-		-
SP2:			-		-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PDGFRB

1 Ensembl transcript including schematic representation:

ENST00000261799

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PDGFRB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDGFRB

¹ / ² / ³

5 probe-sets matching PDGFRB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1771_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.95	J03278	1.00	1.00	1.00	1
36993_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.95	M33210	0.20	1.00	0.72	1
74696_r_at²^{, 3}	U95-D	1	1.00	1.00	0.96	1.10	AW003358	0.60	1.00	0.82	1
202273_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002609	0.60	1.00	0.82	1
202273_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PDGFRB for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGGTATGGT

SOURCE GeneReport for Unigene cluster: Hs.509067
Expression variation in blood from EXPOLDB for PDGFRB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDGFRB gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDGFRB¹	--	platelet-derived growth factor receptor, beta polypeptide	88.4(n) 90.74(a)	442985 NM_001003382.1 NP_001003382.1
chimpanzee (Pan troglodytes)	PDGFRB¹	--	platelet-derived growth factor receptor, beta polypeptide	98.09(n) 98.15(a)	462188 XM_518034.2 XP_518034.2
rat (Rattus norvegicus)	Pdgfrb¹	--	platelet derived growth factor receptor, beta polypeptide	83.93(n) 86.51(a)	24629 NM_031525.1 NP_113713.1
mouse (Mus musculus)	Pdgfrb^{1, 5}	18 (30.00 cM)⁵	platelet derived growth factor receptor, beta polypeptide^{1, 5}	83.76(n)¹ 85.97(a)¹	18596¹ NM_008809.1¹ NP_032835.1¹ AI528809⁵ AI845602⁵ (see all 15)
chicken (Gallus gallus)	PDGFRB¹	--	platelet-derived growth factor receptor, beta polypeptide	70.05(n) 68.11(a)	770488 XM_001233829.1 XP_001233830.1

About this table Species with no ortholog for PDGFRB

ENSEMBL Gene Tree for PDGFRB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PDGFRB gene

PDGFRA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/328 NCBI SNPs in PDGFRB are shown (see all 328 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 160)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2302273^1,2	C,F,H,O	149515448(+)	`TGGCTG/ATCTGC`	1	--	ut5¹ ese³		7		EA NA EU WA	2084
	rs3828610^1,2	A,C,F,H	149515818(+)	`TTTTCC/ACTCTG`	1	--	ng3¹		6		MN EA EU WA	712
	rs3756314^1,2	A,C,F	149517539(+)	`ACTGGC/TTCCCA`	1	--	ng3¹		1		EA	1486
	rs3756312^1,2	A,C,F	149517387(+)	`CCCAGG/ACCCCT`	1	--	ng3¹		4		NA EA	362
--	rs2229561^1,2	A,C,F	149475480(-)	`CCCCCA/C/GCTGCC`	1	--	ut3¹ trp³		1		MN	36
	rs6887454^1,2	C,F,H	149475177(+)	`GATTCG/AGTCTC`	1	--	ut3¹		7		EU EA WA NA	550
	rs2229562^1,2	C,F,H	149475446(-)	`GCCTGA/GCCGGG`	1	--	ut3¹ ese³		9		MN EU EA WA	882
	rs17110944^1,2	C,F,H	149495590(+)	`AGAGAT/ACTGTG`	1	F/I	mis¹ ese³		11		NA EU EA WA	976
	rs34586048^1,2	C,F	149493432(+)	`TAACTC/TGGCAC`	1	E/K	mis¹		4		EU EA WA	420
	rs3756311^1,2	A,C	149517273(+)	`CCCACA/GGGGCA`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for PDGFRB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 173410

UniProtKB/Swiss-Prot: PGFRB_HUMAN, P09619

A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic

leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal

clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML)

A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia.

Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution

of leukemia and eosinophilia

A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic

leukemia. Translocation t(5;17)(q33;p11.2) with SPECC1

A chromosomal aberration involving PDGFRB is a cause in many instances of chronic

myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6

on chromosome 12 creating an PDGFRB-ETV6 fusion protein

A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative

disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a

PDE4DIP-PDGFRB fusion protein

10/95 Novoseek disease relationships for PDGFRB gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gastrointestinal stromal tumor	78.30	9	15224284 (1), 16294026 (1), 11914627 (1), 19366796 (1) (see all 9)
leukemia myelomonocytic chronic	73.15	13	11588050 (2), 9616134 (1), 12908555 (1), 19100521 (1) (see all 11)
myeloproliferative neoplasm	72.06	8	19006078 (1), 18971950 (1), 19175693 (1), 19100521 (1)
hypereosinophilic syndrome	71.56	1	18706197 (1)
myeloproliferative disorders	68.05	29	17296564 (3), 18262053 (2), 15477214 (2), 10910073 (1) (see all 19)
myeloid leukemia chronic	66.43	13	12480706 (1), 16143881 (1), 11914627 (1), 12181402 (1) (see all 13)
dermatofibrosarcoma protuberans	64.15	4	17431412 (1), 15532894 (1), 15794712 (1)
tumors	62.54	274	16988946 (5), 15705896 (4), 15385107 (4), 12644539 (4) (see all 99)
idiopathic hypereosinophilic syndrome	53.35	1	19301902 (1)
mastocytosis systemic	51.57	8	15995325 (1)

About this table

Genetic Association Database: PDGFRB
Human Genome Epidemiology Navigator: PDGFRB (5 documents)
Tumor Gene Database: PDGFRB

(Possibly Related Articles in Doctor's Guide)
About This Section

Study of Dasatinib or 800 Mg of Imatinib Mesylate Shows Patients Treated With Dasatinib Achieved High Cytogenetic Responses and Prolonged Progression-Free Survival

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/823 PubMed articles for PDGFRB gene (see all 823 ):

Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PubMed id 9373237)^{1, 3, 4} Abe A....Saito H. (1997)
HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). (PubMed id 15087372)^{3, 4} Morerio C....Panarello C. (2004)
Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms. (PubMed id 15380338)^{3, 6} Bruck P....Ottmann O.G. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors. (PubMed id 11882663)^{3, 4} Karthikeyan S.... Ladias J.A.A. (2002)
NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex. (PubMed id 11567151)^{3, 4} Pauptit R.A.... Murshudov G.N. (2001)
PDGF-D is a specific, protease-activated ligand for the PDGF beta- receptor. (PubMed id 11331881)^{3, 4} Bergsten E.... Eriksson U. (2001)
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PubMed id 10805725)^{3, 4} Arcaro A....Domin J. (2000)
APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. (PubMed id 9989826)^{3, 4} Yokouchi M.... Yoshimura A. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5159	HGNC: 8804	AceView: PDGFRBandCSF1R	Ensembl:ENSG00000113721	euGenes: HUgn5159
ECgene: PDGFRB	H-InvDB: PDGFRB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PDGFRB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PDGFRB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PDGFRB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDGFRB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDGFRB		Antibodies for PDGFRB
	Explore super-pooled esiRNAs		Proteins for PDGFRB
	Lentivirus-delivered shRNAs for PDGFRB		Small molecules for PDGFRB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PDGFRB)
	Antibodies (PDGFRB)
	Chimera RNAi (PDGFRB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PDGFRB (PDGFR beta)

	Recombinant Proteins (PDGF Receptor alpha + beta, PDGF Receptor beta)
	Antibodies (PDGF Receptor alpha + beta, PDGF Receptor beta)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PDGFRB

	Drugs for PDGFRB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PDGFRB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PDGFRB Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PDGFRB Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for PDGFRB

Summaries
for PDGFRB

Genomic Location
for PDGFRB

Proteins
for PDGFRB

Protein Domains/
Families
for PDGFRB

Gene Function
for PDGFRB

Pathways & Interactions
for PDGFRB

Drugs & Compounds
for PDGFRB

Transcripts
for PDGFRB

Expression
for PDGFRB

Orthologs
for PDGFRB

Paralogs
for PDGFRB

SNPs/Variants
for PDGFRB

Disorders & Mutations
for PDGFRB

Medical News
for PDGFRB

Publications
for PDGFRB

Search for PDGFRB

Genome Databases showing PDGFRB

Other Databases showing PDGFRB

Specialized Databases showing PDGFRB

Licensable Technologies
for PDGFRB

Services
for PDGFRB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDGFRB Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor PDGFRB

Summariesfor PDGFRB

Genomic Locationfor PDGFRB

Proteinsfor PDGFRB

Protein Domains/Familiesfor PDGFRB

Gene Functionfor PDGFRB

Pathways & Interactionsfor PDGFRB

Drugs & Compoundsfor PDGFRB

Transcriptsfor PDGFRB

Expression for PDGFRB

Orthologsfor PDGFRB

Paralogsfor PDGFRB

SNPs/Variantsfor PDGFRB

Disorders & Mutationsfor PDGFRB

Medical Newsfor PDGFRB

Publicationsfor PDGFRB

Search for PDGFRB

Genome Databases showing PDGFRB

Other Databases showing PDGFRB

Specialized Databases showing PDGFRB

Licensable Technologiesfor PDGFRB

Servicesfor PDGFRB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDGFRB

Summaries
for PDGFRB

Genomic Location
for PDGFRB

Proteins
for PDGFRB

Protein Domains/
Families
for PDGFRB

Gene Function
for PDGFRB

Pathways & Interactions
for PDGFRB

Drugs & Compounds
for PDGFRB

Transcripts
for PDGFRB

Expression
for PDGFRB

Orthologs
for PDGFRB

Paralogs
for PDGFRB

SNPs/Variants
for PDGFRB

Disorders & Mutations
for PDGFRB

Medical News
for PDGFRB

Publications
for PDGFRB

Licensable Technologies
for PDGFRB

Services
for PDGFRB