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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDGFRA Gene

protein-coding   GIFtS: 77
GCID: GC04P055095

platelet-derived growth factor receptor, alpha polypeptide
 Explore 169 diseases affiliated with
PDGFRA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDGFRA    

Aliases
for PDGFRA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Platelet-Derived Growth Factor Receptor, Alpha Polypeptide1 2     EC 2.7.10.13 8
PDGFR21 2 3     CD140a1
Alpha-Type Platelet-Derived Growth Factor Receptor2 3     CD140A2
Platelet-Derived Growth Factor Receptor 22 3     PDGFRA/BCR Fusion2
PDGF-R-Alpha1     Platelet-Derived Growth Factor Receptor Alpha2
PDGFR-22 3     Rearranged-In-Hypereosinophilia-Platelet Derived Growth Factor Receptor Alpha
Fusion Protein2
PDGFR-Alpha1     Alpha Platelet-Derived Growth Factor Receptor3
RHEPDGFRA2 3     Platelet-Derived Growth Factor Alpha Receptor3
CD140 Antigen-Like Family Member A2 3     EC 2.7.108
CD140a Antigen2 3     

External Ids:    HGNC: 88031   Entrez Gene: 51562   Ensembl: ENSG000001348537   OMIM: 1734905   UniProtKB: P162343   

Export aliases for PDGFRA gene to outside databases

Previous GC identifers: GC04P054806 GC04P055065 GC04P054945 GC04P055010 GC04P054936 GC04P051043


Summaries
for PDGFRA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDGFRA:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a
receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both
platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in
organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic
hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
(provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an
essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on
the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the
differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic
closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract,
and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration
and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules,
and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB,
heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades;
the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between
PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the
cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the
activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and
thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases
MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B.
Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream
effectors, and by rapid internalization of the activated receptor

summary for PDGFRA:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFRA


Genomic Views
for PDGFRA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDGFRA gene promoter:
         Max1   MAZR   AML1a   YY1   GATA-1   c-Rel   SRY   COMP1   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDGFRA promoter sequence
   Search SABiosciences Chromatin IP Primers for PDGFRA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

PDGFRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFRA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P055095:  view genomic region     (about GC identifiers)

Start:
 55,095,264 bp from pter      End:
 55,164,414 bp from pter
Size:
 69,151 bases      Orientation:
 plus strand

Proteins
for PDGFRA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234 (See protein sequence)
Recommended Name: Platelet-derived growth factor receptor alpha precursor  
Size: 1089 amino acids; 122670 Da
Subunit: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in
the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where
both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via
SH2 domain) (By similarity). Interacts (tyrosine phosphorylated) with SHF (via SH2 domain). Interacts (tyrosine
phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine
phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7. Interacts
with human cytomegalovirus/HHV-5 envelop glycoprotein B/gB
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly
internalized and degraded
Sequence caution: Sequence=AAP69563.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for PDGFRA:
1GQ5 (3D)    
Secondary accessions: B2RE69 E9PBH0 Q6P4H5 Q96KZ7 Q9UD28
Alternative splicing: 3 isoforms:  P16234-1   P16234-2   P16234-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDGFRA: NX_P16234

Post-translational modifications:

  • N-glycosylated1
  • Ubiquitinated, leading to its degradation (Probable)1
  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of
    • the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is
    important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with
    PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is
    important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for
    interaction with PLCG11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16234

    • 4/39 DME Specific Peptides for PDGFRA (P16234) (see all 39)
     QVARGME  RDLAARN  LGGTPYP  RSYVILS 

    PDGFRA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006197.1  
    ENSEMBL proteins: 
     ENSP00000257290   ENSP00000425648   ENSP00000425626   ENSP00000424218   ENSP00000425902  
     ENSP00000426472   ENSP00000425232  
    Reactome Protein details: P16234
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PDGFRA Protein
    R&D Systems Recombinant & Natural Proteins for PDGFRA (PDGF R alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PDGFRA
    OriGene Protein Over-expression Lysate: PDGFRA
    OriGene Custom Protein Services for PDGFRA 
    GenScript Custom Purified and Recombinant Proteins Services for PDGFRA
    Novus Biologicals PDGFRA Proteins
    Novus Biologicals PDGFRA Lysate
    Sino Biological Recombinant Protein for PDGFRA
    ProSpec Recombinant Protein for PDGFRA
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA2536956
    GO:0009897external side of plasma membrane IEA--


    PDGFRA for ontologies           About GeneDecksing



    PDGFRA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFRA
    R&D Systems Antibodies for PDGFRA (PDGF R alpha)
    Cell Signaling Technology (CST) Antibodies for PDGFRA 
    OriGene Antibodies (see all 2): PDGFRA
    OriGene Custom Antibody Services for PDGFRA 
    GenScript Custom Superior Antibodies Services for PDGFRA
    Novus Biologicals PDGFRA Antibodies
    Abcam antibodies for PDGFRA 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for PDGFRA

    Assay Products for PDGFRA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for PDGFRA (PDGF R alpha)         (see all)
    GenScript Custom Assay Services for PDGFRA
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PDGFRA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PDGFRA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDGFRA for domains           About GeneDecksing

    5/14 InterPro domains/families (see all 14):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR009134 Tyr_kinase_VEGFR_rcpt_N

    Graphical View of Domain Structure for InterPro Entry P16234

    ProtoNet protein and cluster: P16234

    4 Blocks protein families:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature


    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Function
    for PDGFRA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an
    essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on
    the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the
    differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic
    closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract,
    and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration
    and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules,
    and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB,
    heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades;
    the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between
    PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the
    cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the
    activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and
    thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases
    MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B.
    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream
    effectors, and by rapid internalization of the activated receptor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB
    leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and
    sorafenib

         Genatlas biochemistry entry for PDGFRA:
    platelet-derived growth factor receptor,alpha,growth arrest specific gene (gas),subunit,homodimerizing and
    heterodimerizing with PDGFRB,immunoglobulin superfamily

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target PDGFRA:
    hsa-let-7b (MIRT004955)

    OriGene 3'-UTR Clone: PDGFRA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFRA
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFRA (see all 98):
    hsa-miR-140-5p hsa-miR-642a hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFRA (see all 7)
    OriGene shRNA RFP: PDGFRA
    OriGene siRNA: PDGFRA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFRA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDGFRA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRA (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PDGFRA (NM_006206)
    Sino Biological Human cDNA Clone for PDGFRA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PDGFRA
    LifeMap BioReagents: cell line associated with PDGFRA: PureStem 4D20.8, NCr-fac Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRA

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA1646396
    GO:0005018platelet-derived growth factor alpha-receptor activity IMP2554309
    GO:0005021vascular endothelial growth factor-activated receptor activity IDA17470632
    GO:0005161platelet-derived growth factor receptor binding IPI2542288
    GO:0005515protein binding IPI17470632


    PDGFRA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PDGFRA:
     Decreased viability  Increased colony dispersion (i 

    Animal Models:
         Mouse knock-outs for PDGFRA: Pdgfratm2Sor Pdgfratm1Sor
         15/24 MGI mutant phenotypes (inferred from 15 alleles) (MGI details for Pdgfra) (see all 24):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 

    PDGFRA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDGFRA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/49 super-pathways (see all 49) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/13 pathways (see all 13)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    4GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for PDGFRA (see all 6)
        Transcription PPAR Pathway
    Selected targets of Oct-3/4
    Development PDGF signaling via MAPK cascades
    Development PDGF signaling via STATs and NF-kB
    Signal transduction IP3 signaling

    5/58 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDGFRA (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for PDGFRA
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for PDGFRA
        Akt Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for PDGFRA
        Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Transcription PPAR Pathway
    Development PDGF signaling via MAPK cascades
    Signal transduction IP3 signaling

    5/9 BioSystems Pathways for PDGFRA (see all 9) 
        Signaling Pathways in Glioblastoma
    Angiogenesis
    Focal Adhesion
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    5/30        Reactome Pathways for PDGFRA (see all 30)
        Signaling by EGFR in Cancer
    Disease
    Signaling by ERBB2
    GAB1 signalosome
    PI3K/AKT activation

    1 PharmGKB Pathway for PDGFRA
        Vemurafenib Pathway, Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for PDGFRA) (see all 11):
        MAPK signaling pathway
    Calcium signaling pathway
    Cytokine-cytokine receptor interaction
    Endocytosis
    Focal adhesion


    PDGFRA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDGFRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for PDGFRA (P162342, 3 ENSP000002572904) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461082, 3, ENSP000003005744MINT-8027048 MINT-8027033 MINT-8027093 I2D: score=4 STRING: ENSP00000300574
    CRKLP461092, 3, ENSP000003463004MINT-8027078 MINT-8027063 I2D: score=4 STRING: ENSP00000346300
    PLCG1P191742, 3, ENSP000002440074MINT-8033627 I2D: score=4 STRING: ENSP00000244007
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    PDGFAP040853, ENSP000003465084I2D: score=3 STRING: ENSP00000346508
    About this table

    Gene Ontology (GO): 5/59 biological process terms (GO ID links to tree view) (see all 59):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001553luteinization ISS--
    GO:0001701in utero embryonic development IEA--
    GO:0001775cell activation TAS10508235
    GO:0007204elevation of cytosolic calcium ion concentration IMP2554309
    GO:0008210estrogen metabolic process IEA--


    PDGFRA for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDGFRA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDGFRA for compounds           About GeneDecksing

    EMD Millipore small molecules for PDGFRA:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDGFRA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PP 121Dual kinase inhibitor; inhibits PI 3K family kinases[1092788-83-4]
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    AG 18EGFR/PDGFR-kinase inhibitor[118409-57-7]

    2 HMDB Compounds for PDGFRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for PDGFRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Becaplerminc-sis (see all 5)165101-51-9target--1702511 12632922 10070317 14506245 7665222
    ImatinibImatinib Mesylate (see all 3)152459-95-5targetantagonist15894928 15995325 15946589 15928335 15921304
    SunitinibSU11248 (see all 3)557795-19-4targetantagonist16638875

    10/21 Novoseek chemical compound relationships for PDGFRA gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 94.1 222 14645423 (5), 15928335 (4), 16294026 (3), 19013640 (3) (see all 99)
    sunitinib 81.8 13 19366796 (3), 17041096 (2), 17710208 (1), 17272980 (1) (see all 9)
    tyrosine 80.3 197 18478259 (3), 15750190 (2), 17452978 (2), 18084259 (2) (see all 99)
    pkc 412 68.8 4 12781364 (2), 17452978 (1), 17087936 (1)
    ag-1296 57.5 1 16439802 (1)
    vegf 35.7 27 18950958 (4), 18006812 (2), 19948069 (2), 15334938 (2) (see all 13)
    hydroxyurea 25.7 1 20010473 (1)
    rapamycin 23.1 1 17041096 (1)
    phosphatidylinositol 13.7 3 17452978 (1), 17141222 (1), 16186508 (1)
    phosphotyrosine 8.59 3 8188664 (1), 15677564 (1)

    Search CenterWatch for drugs/clinical trials and news about PDGFRA / PGFRA 

    Transcripts
    for PDGFRA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDGFRA gene: 
    NM_006206.4  

    Unigene Cluster for PDGFRA:

    Platelet-derived growth factor receptor, alpha polypeptide
    Hs.74615  [show with all ESTs]
    Unigene Representative Sequence: NM_006206
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257290(uc003haa.3 uc003han.4) ENST00000508170(uc003hal.3)
    ENST00000509092(uc010igq.1) ENST00000512143 ENST00000509490(uc003ham.2)
    ENST00000503856 ENST00000504461 ENST00000512522 ENST00000461294 ENST00000507536(uc003hao.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: PDGFRA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFRA
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFRA (see all 98):
    hsa-miR-140-5p hsa-miR-642a hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFRA (see all 7)
    OriGene shRNA RFP: PDGFRA
    OriGene siRNA: PDGFRA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFRA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRA (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFRA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PDGFRA (NM_006206)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFRA

    Additional cDNA sequence: 

    AK308353.1 AK311006.1 AK316578.1 BC015186.1 BC063414.1 L25829.1 M21574.1 M30494.1 
    X76079.1 X95095.1 

    18 DOTS entries:

    DT.448233  DT.40293682  DT.91753879  DT.100788397  DT.101975351  DT.91753880  DT.91753891  DT.95269491 
    DT.424870  DT.100788396  DT.121259196  DT.121259214  DT.100654088  DT.121259206  DT.95305194  DT.121259225 
    DT.70104408  DT.99977868 

    24/240 AceView cDNA sequences (see all 240):

    F03485 AA969144 R81781 W70251 BM706203 F07234 CN483903 N69055 
    BM715043 AA207000 CA447048 F03514 F04824 F02116 H90646 AA055050 
    AW272703 BU737962 BG939663 BX480820 BM721602 BQ446932 BF196702 BC015186 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                    -     -     -     -                                   -                                                     -                 -         
    SP2:                    -     -     -     -                                   -                                                     -                 -         
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -                                                                                                                     

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:  -           -     -                                             
    SP2:                                                                  
    SP3:  -                                                               
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for PDGFRA

    Expression
    for PDGFRA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDGFRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATTGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PDGFRA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/22 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 22) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    HypoblastHypoblastHypoblast CellsExtraembryonic Tissues
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest CellsNeural Crest
    HeartOutflow TractNeural Crest Outflow Tract CellsNeural Crest
    HeartOutflow Tract CushionOutflow Tract Cushion CellsEndocardium, Neural Crest
    Lateral Plate MesodermIntraembryonic CoelomCoelomic Epithelial CellsReproductive System
    Lateral Plate MesodermSplanchnic MesodermPericytesPericytes
    LiverMesoblastic Supporting StromaPre-stellate CellsLiver
    LiverMesoblastic Supporting StromaSubmesothelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/20 LifeMap Cells (see all 20) 
    NameCategory
    Neural stem cells (Fetal Stem / Progenitor Cell)Spinal Cord
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Spheres (Directed differentia...)
    Chondrocyte-like cells (Direct differentiati...)Bone, Cartilage
    Mesoderm-like cells (Direct differentiati...)Mesoderm
    Mesendoderm-like cells (A scalable, suspensi...)

    See PDGFRA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDGFRA

    SOURCE GeneReport for Unigene cluster: Hs.74615

    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Tissue specificity: Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth
    muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including PDGFRA (see all 13): 
              Liver Cancer in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Notch Signaling Targets in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PDGFRA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PDGFRA gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PDGFRA1 platelet-derived growth factor receptor, alpha polypeptide 75.84(n)
    80.57(a)    		   395509  NM_204749.1  NP_990080.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDGFRA6
    		 --
    		 77(a)
    		 1 ↔ 1
    		 5(104062121-104104735)
    African clawed frog
    (Xenopus laevis)    		 Amphibia pdgfra-prov2 platelet derived growth factor receptor, alpha polypeptide 76.73(n)    BC043948.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pdgfra2 platelet derived growth factor receptor alpha 78.74(n)   30745  AF200951.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG32773 protein amino acid phosphorylation protein
    tyrosine more    		 32(a)   23E3   --


    ENSEMBL Gene Tree for PDGFRA (if available)
    TreeFam Gene Tree for PDGFRA (if available) 

    Paralogs
    for PDGFRA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDGFRA gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  FGFR32  KIT2  RET2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    5 SIMAP similar genes for PDGFRA using alignment to 5 protein entries:     PGFRA_HUMAN (see all proteins):
    CSF1R    EPHA2    KIT    PDGFRB    FLT3

    PDGFRA for paralogs           About GeneDecksing



    Genomic Variants
    for PDGFRA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): PDGFRA
    5/26 SABiosciences Cancer Mutation PCR Assays for PDGFRA (see all 26):
    Cosmic IdAA Change
    12402p.M844_S847del
    12401p.D842_M844del
    12399p.D846Y
    42897p.C235Y
    13348p.G829R
    5/8 SABiosciences Cancer Mutation PCR Arrays containing PDGFRA (see all 8):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Soft Tissue Tumors
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing PDGFRA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDGFRA
    DNA2.0 Custom Variant and Variant Library Synthesis for PDGFRA

    Disorders / Diseases
    for PDGFRA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDGFRA for disorders           About GeneDecksing

    OMIM gene information: 173490   
    OMIM disorders: 606764  607685  
    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
  • Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome.
    • Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). Mutations
    that cause overexpression and/or constitutive activation of PDGFRA may be a cause of hypereosinophilic syndrome
  • Defects in PDGFRA are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. Note=Mutations that cause
    • constitutive activation of PDGFRA may be a cause of gastrointestinal stromal tumor (GIST)

    20/169 diseases for PDGFRA (see all 169):    About MalaCards
    gastrointestinal stromal tumor    hypereosinophilic syndrome    hypereosinophilic syndrome, idiopathic, resistant to imatinib    malignant peripheral nerve sheath tumor
    carney triad    neural tube defect    gastrointestinal stromal tumor, somatic    rosai-dorfman disease
    supratentorial primitive neuroectodermal tumor    primitive neuroectodermal tumor    cleft lip/palate    juvenile myelomonocytic leukemia
    chronic venous leg ulcers    polycythemia vera    central nervous system lymphoma    lymphomatoid papulosis
    spina bifida    fibrous histiocytoma    graft versus host disease    dermatofibrosarcoma protuberans

    12 diseases from the University of Copenhagen DISEASES database for PDGFRA:
    Gastrointestinal stromal tumor     Eosinophilia     Mastocytosis     Leukemia
    Malignant glioma     Endomyocardial fibrosis     Chondroma     Sarcoma
    Mesenchymal cell neoplasm     Neurofibromatosis     Myelofibrosis     Leiomyosarcoma

    10/94 Novoseek disease relationships for PDGFRA gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrointestinal stromal tumor 95.8 173 18657298 (4), 20096441 (3), 16630479 (2), 17638656 (2) (see all 99)
    leukemia eosinophilic 87.3 12 16418325 (1), 16498388 (1), 15995324 (1), 19210352 (1) (see all 9)
    hypereosinophilic syndrome 86.9 19 12842979 (1), 16418325 (1), 17634706 (1), 16965435 (1) (see all 16)
    carney triad 82.4 4 17193822 (1), 17549339 (1), 18312355 (1), 17021135 (1)
    idiopathic hypereosinophilic syndrome 73.9 6 16343267 (1), 19176456 (1), 15772698 (1), 12660384 (1)
    idiopathic eosinophilia 73.7 2 16610578 (1)
    myeloproliferative neoplasm 70.6 8 20107158 (2), 18971950 (1), 19175693 (1), 20126996 (1)
    tumors 67.9 305 8548759 (6), 18758297 (4), 17527083 (4), 20393746 (4) (see all 99)
    mastocytosis systemic 66.4 9 16610578 (1), 12676775 (1), 15995325 (1), 15036941 (1)
    neurofibromatosis type 1 65.4 10 15540118 (2), 16143881 (1), 17193822 (1), 18671247 (1) (see all 8)

    Genetic Association Database (GAD): PDGFRA
    Human Genome Epidemiology (HuGE) Navigator: PDGFRA (58 documents)
    Tumor Gene Database (TGDB): PDGFRA

    Export disorders for PDGFRA gene to outside databases

    Publications
    for PDGFRA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDGFRA gene, integrated from 9 sources (see all 775):
    (articles sorted by number of sources associating them with PDGFRA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. (PubMed id 15928335)1, 2, 7, 9 Corless C.L....Heinrich M.C. (2005)
    2. Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity. (PubMed id 15894928)1, 7, 9 Yi E.S....Weidner N. (2005)
    3. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. (PubMed id 8188664)1, 2, 9 Vassbotn F.S....Holmsen H. (1994)
    4. Promotor genotype of the platelet-derived growth factor receptor-alpha gene shows population stratification but not association with spina bifida meningomyelocele. (PubMed id 16283668)1, 4, 9 Au K.S....King T.M. (2005)
    5. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. (PubMed id 12660384)1, 2, 9 Cools J.... Gilliland D.G. (2003)
    6. Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). (PubMed id 16135486)1, 4, 9 Martin J....Buesa J.M. (2005)
    7. PDGFRA activating mutations in gastrointestinal stromal tumors. (PubMed id 12522257)1, 2, 9 Heinrich M.C....Fletcher J.A. (2003)
    8. Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects. (PubMed id 11175793)1, 4, 9 Joosten P.H....Van Zoelen E.J. (2001)
    9. Novel imatinib-sensitive PDGFRA-activating point muta tions in hypereosinophilic syndrome induce growth factor independence and leuke mia-like disease. (PubMed id 21224473)1, 2 Elling C....Koschmieder S. (2011)
    10. The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination. (PubMed id 21596750)1, 2 Severe N.... Marie P.J. (2011)

    External Searches for PDGFRA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDGFRA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5156 HGNC: 8803 AceView: PDGFRA Ensembl:ENSG00000134853 euGenes: HUgn5156
    ECgene: PDGFRA Kegg: 5156 H-InvDB: PDGFRA

    Other Databases showing PDGFRA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDGFRA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDGFRA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFRA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PDGFRA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDGFRA gene:
    Search GeneIP for patents involving PDGFRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PDGFRA gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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     GenScript Custom Purified and Recombinant Proteins Services for PDGFRA GenScript cDNA clones with any tag delivered in your preferred vector for PDGFRA
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Cell Line associated with PDGFRA: PureStem 4D20.8, NCr-fac Progenitor
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRA
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PDGFRA
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     ThermoFisher Antibody for PDGFRA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRA
           
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