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PDGFRA Gene

protein-coding   GIFtS: 76
GCID: GC04P055095

Platelet-Derived Growth Factor Receptor, Alpha Polypeptide

  See PDGFRA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet-Derived Growth Factor Receptor, Alpha Polypeptide1 2     EC 2.7.10.13 8
Alpha-Type Platelet-Derived Growth Factor Receptor2 3     CD140A2
Platelet-Derived Growth Factor Receptor 22 3     PDGFRA/BCR Fusion2
PDGF-R-alpha2 3     Platelet-Derived Growth Factor Receptor Alpha2
PDGFR-22 3     Rearranged-In-Hypereosinophilia-Platelet Derived Growth Factor Receptor
Alpha Fusion Protein2
PDGFR22 3     PDGFR-alpha3
RHEPDGFRA2 3     Alpha Platelet-Derived Growth Factor Receptor3
CD140 Antigen-Like Family Member A2 3     Platelet-Derived Growth Factor Alpha Receptor3
CD140a Antigen2 3     EC 2.7.108

External Ids:    HGNC: 88031   Entrez Gene: 51562   Ensembl: ENSG000001348537   OMIM: 1734905   UniProtKB: P162343   

Export aliases for PDGFRA gene to outside databases

Previous GC identifers: GC04P054806 GC04P055065 GC04P054945 GC04P055010 GC04P054936 GC04P051043


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDGFRA Gene:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor
family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor
bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed
of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays
a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated
with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety
of other cancers. (provided by RefSeq, Mar 2012)

GeneCards Summary for PDGFRA Gene:
PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) is a protein-coding gene. Diseases associated with PDGFRA include hypereosinophilic syndrome, and gastrointestinal stromal tumor, somatic. GO annotations related to this gene include platelet-derived growth factor receptor binding and protein homodimerization activity. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an
essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending
on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the
differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and
cephalic closure during embryonic development. Required for normal development of the mucosa lining the
gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.
Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of
agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands -
homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the
activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated
by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation
of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates
PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1
signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by
protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid
internalization of the activated receptor

summary for PDGFRA Gene:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFRA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_022853.16  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDGFRA gene promoter:
         Max1   MAZR   AML1a   YY1   GATA-1   c-Rel   SRY   COMP1   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDGFRA promoter sequence
   Search Chromatin IP Primers for PDGFRA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDGFRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

PDGFRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFRA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P055095:  view genomic region     (about GC identifiers)

Start:
55,095,264 bp from pter      End:
55,164,414 bp from pter
Size:
69,151 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234 (See protein sequence)
Recommended Name: Platelet-derived growth factor receptor alpha precursor  
Size: 1089 amino acids; 122670 Da
Subunit: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB.
Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor
dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine
phosphorylated) with SHB (via SH2 domain) (By similarity). Interacts (tyrosine phosphorylated) with SHF (via SH2
domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with
PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with
CRK, GRB2 and GRB7. Interacts with human cytomegalovirus/HHV-5 envelop glycoprotein B/gB
Sequence caution: Sequence=AAP69563.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for PDGFRA:
1GQ5 (3D)    
Secondary accessions: B2RE69 E9PBH0 Q6P4H5 Q96KZ7 Q9UD28
Alternative splicing: 3 isoforms:  P16234-1   P16234-2   P16234-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDGFRA: NX_P16234

Explore proteomics data for PDGFRA at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitinated, leading to its degradation (Probable)1
  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit
    of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and
    Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for
    interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at
    Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and
    Tyr-1018 is important for interaction with PLCG11
  • Glycosylation2 at Asn42, Asn76, Asn103, Asn179, Asn353, Asn359, Asn458, Asn468
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDGFRA (P16234) (see all 39)
     QVARGME  RDLAARN  LGGTPYP  RSYVILS 


    See PDGFRA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006197.1  
    ENSEMBL proteins: 
     ENSP00000257290   ENSP00000425648   ENSP00000425626   ENSP00000424218   ENSP00000425902  
     ENSP00000426472   ENSP00000425232  
    Reactome Protein details: P16234

    PDGFRA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PDGFRA Protein
    R&D Systems Recombinant & Natural Proteins for PDGFRA (PDGF R alpha)
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    OriGene Purified Protein for PDGFRA
    OriGene Protein Over-expression Lysate for PDGFRA
    OriGene MassSpec for PDGFRA
    OriGene Custom Protein Services for PDGFRA
    GenScript Custom Purified and Recombinant Proteins Services for PDGFRA
    Novus Biologicals PDGFRA Proteins
    Novus Biologicals PDGFRA Lysate
    Sino Biological Recombinant Protein for PDGFRA
    Sino Biological Cell Lysate for PDGFRA
    ProSpec Recombinant Protein for PDGFRA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PDGFRA 

     
    antibodies-online proteins for PDGFRA (10 products) 

     
    antibodies-online peptides for PDGFRA

    PDGFRA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFRA
    R&D Systems Antibodies for PDGFRA (PDGF R alpha)
    Cell Signaling Technology (CST) Antibodies for PDGFRA 
    OriGene Antibodies for PDGFRA
    OriGene Custom Antibody Services for PDGFRA
    Novus Biologicals PDGFRA Antibodies
    Abcam antibodies for PDGFRA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PDGFRA
    antibodies-online antibodies for PDGFRA (316 products) 

    PDGFRA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDGFRA
    R&D Systems ELISAs for PDGFRA (PDGF R alpha)         (see all)
    GenScript Custom Assay Services for PDGFRA
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PDGFRA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PDGFRA 
    antibodies-online kits for PDGFRA (26 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: platelet-derived growth factor receptor, alpha polypeptide
    PDGF (platelet-derived growth factor) receptor family
    PDGF (platelet-derived growth factor) receptor family

    Selected InterPro protein domains (see all 14):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P16234

    ProtoNet protein and cluster: P16234

    4 Blocks protein domains:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature


    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PDGFRA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGFRA_HUMAN, P16234
    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an
    essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending
    on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the
    differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and
    cephalic closure during embryonic development. Required for normal development of the mucosa lining the
    gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.
    Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of
    agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands -
    homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the
    activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated
    by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation
    of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
    1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates
    PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1
    signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
    activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by
    protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid
    internalization of the activated receptor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or
    PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib,
    nilotinib and sorafenib

         Genatlas biochemistry entry for PDGFRA:
    platelet-derived growth factor receptor,alpha,growth arrest specific gene (gas),subunit,homodimerizing and
    heterodimerizing with PDGFRB,immunoglobulin superfamily

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA1646396
    GO:0005018platelet-derived growth factor alpha-receptor activity IMP2554309
    GO:0005021vascular endothelial growth factor-activated receptor activity IDA17470632
         
    Find genes that share ontologies with PDGFRA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PDGFRA:
     Decreased viability  Increased colony dispersion (i 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Pdgfra) (see all 24):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 

    Find genes that share phenotypes with PDGFRA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PDGFRA: Pdgfratm2Sor Pdgfratm1Sor

       genOway: Develop your customized and physiologically relevant rodent model for PDGFRA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDGFRA:
    hsa-mir-34a-5p (MIRT006212), hsa-mir-26b-5p (MIRT030342), hsa-mir-140-5p (MIRT006218), hsa-let-7b-5p (MIRT004955)

    Block miRNA regulation of human, mouse, rat PDGFRA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDGFRA (see all 98):
    hsa-miR-140-5p hsa-miR-642a hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PDGFRA
    Predesigned siRNA for gene silencing in human, mouse, rat PDGFRA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDGFRA

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDGFRA (NM_006206)
    Sino Biological Human cDNA Clone for PDGFRA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRA
    Addgene plasmids for PDGFRA 

    Cell Line
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    ESI BIO PureStem Progenitor for PDGFRA: 
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRA

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12826) for PDGFRA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGFRA_HUMAN, P16234: Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly
    internalized and degraded
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytoskeleton2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA2536956
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with PDGFRA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDGFRA About   (see all 55)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Melanoma0.43
    Signaling Pathways in Glioblastoma0.36
    2Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60


    Find genes that share SuperPaths with PDGFRA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PDGFRA
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDGFRA (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for PDGFRA
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for PDGFRA
        Akt Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for PDGFRA
        Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Transcription PPAR Pathway
    Development PDGF signaling via MAPK cascades
    Signal transduction IP3 signaling

    Selected BioSystems Pathways for PDGFRA (see all 9)
        Angiogenesis
    Focal Adhesion
    Cardiac Progenitor Differentiation
    Signaling Pathways in Glioblastoma
    Regulation of Actin Cytoskeleton


    4 Reactome Pathways for PDGFRA
        Downstream signal transduction
    Constitutive PI3K/AKT Signaling in Cancer
    Signaling by PDGF
    PIP3 activates AKT signaling

    1 PharmGKB Pathway for PDGFRA
        Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PDGFRA) (see all 16):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway
    Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDGFRA (see all 13): 
              Liver Cancer in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Notch Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PDGFRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDGFRA (P162341, 2, 3 ENSP000002572904) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 2, 3, ENSP000003005744EBI-2861522,EBI-886 MINT-8027048 MINT-8027033 MINT-8027093 I2D: score=4 STRING: ENSP00000300574
    CRKLP461092, 3, ENSP000003463004MINT-8027078 MINT-8027063 I2D: score=4 STRING: ENSP00000346300
    PLCG1P191742, 3, ENSP000002440074MINT-8033627 I2D: score=4 STRING: ENSP00000244007
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    PDGFAP040853, ENSP000003465084I2D: score=3 STRING: ENSP00000346508
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001553luteinization ISS--
    GO:0001701in utero embryonic development IEA--
    GO:0001775cell activation TAS10508235
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----

    Find genes that share ontologies with PDGFRA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PDGFRA (see all 14)     About this table
    CompoundAction CAS #
    Amuvatinib (MP-470, HPK 56)Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3[850879-09-3]
    Crenolanib (CP-868596)Potent and selective PDGFR-beta inhibitor[670220-88-9]
    Flumatinib mesylatemulti-kinase inhibitor for c-Abl, PDGFRbeta and c-Kit[895519-91-2]
    Imatinib Mesylate (STI571)Multi-target kinase inhibitor of abl, c-kit, and PDGFR[220127-57-1]
    Masitinib (AB1010)tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor[790299-79-5]
    MK-2461potent inhibitor of Met, Ron, Flt1, Flt 3, PDGFRbeta, and Mer with IC50 of 2.5 nM, 7 nM, 10 nM, 22 nM, 22 nM and 24 nM, respectively[917879-39-1]
    Nintedanib (BIBF 1120)Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR[928326-83-4]
    Pazopanib (GW-786034)Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR[635702-64-6]
    Ponatinib (AP24534)pan-BCR-ABL inhibitor[943319-70-8]
    RegorafenibMulti-kinase inhibitor, inhibits VEGFR, PDGFR, FGFR, mutant kit, RET, and Raf-1[755037-03-7]

    Compounds for PDGFRA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    SU 16fPotent and selective PDGFRbeta inhibitor[251356-45-3]

    2 HMDB Compounds for PDGFRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 DrugBank Compounds for PDGFRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Becaplerminc-sis (see all 5)165101-51-9target--1702511 12632922 10070317 14506245 7665222
    ImatinibCGP-57148B (see all 4)152459-95-5targetantagonist15894928 15995325 15946589 15928335 15921304
    PazopanibGW-786034 (see all 2)444731-52-6targetinhibitor17288876
    Ponatinib -- 943319-70-8targetinhibitor19878872
    SunitinibSU011248 (see all 2)557795-19-4targetantagonist16638875
    Regorafenib-- 755037-03-7targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for PDGFRA gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 94.1 222 14645423 (5), 15928335 (4), 16294026 (3), 19013640 (3) (see all 99)
    sunitinib 81.8 13 19366796 (3), 17041096 (2), 17710208 (1), 17272980 (1) (see all 9)
    tyrosine 80.3 197 18478259 (3), 15750190 (2), 17452978 (2), 18084259 (2) (see all 99)
    pkc 412 68.8 4 12781364 (2), 17452978 (1), 17087936 (1)
    ag-1296 57.5 1 16439802 (1)
    vegf 35.7 27 18950958 (4), 18006812 (2), 19948069 (2), 15334938 (2) (see all 13)
    hydroxyurea 25.7 1 20010473 (1)
    rapamycin 23.1 1 17041096 (1)
    phosphatidylinositol 13.7 3 17452978 (1), 17141222 (1), 16186508 (1)
    phosphotyrosine 8.59 3 8188664 (1), 15677564 (1)

    1 PharmGKB related drug/compound annotation for PDGFRA gene    About this table
    Drug/compound PharmGKB Annotation
    pazopanib



    Find genes that share compounds with PDGFRA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PDGFRA gene: 
    NM_006206.4  

    Unigene Cluster for PDGFRA:

    Platelet-derived growth factor receptor, alpha polypeptide
    Hs.74615  [show with all ESTs]
    Unigene Representative Sequence: NM_006206
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257290(uc003haa.3 uc003han.4) ENST00000508170(uc003hal.3)
    ENST00000509092(uc010igq.1) ENST00000512143 ENST00000509490(uc003ham.2)
    ENST00000503856 ENST00000504461 ENST00000512522 ENST00000461294 ENST00000507536(uc003hao.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDGFRA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDGFRA (see all 98):
    hsa-miR-140-5p hsa-miR-642a hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDGFRA
    Predesigned siRNA for gene silencing in human, mouse, rat PDGFRA
    Clone
    Products:
         
    OriGene clones in human, mouse for PDGFRA (see all 8)
    OriGene ORF clones in mouse, rat for PDGFRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDGFRA (NM_006206)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRA
    Addgene plasmids for PDGFRA 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PDGFRA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDGFRA
      QuantiTect SYBR Green Assays in human, mouse, rat PDGFRA
      QuantiFast Probe-based Assays in human, mouse, rat PDGFRA
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12826) for PDGFRA 

    Additional mRNA sequence: 

    AK308353.1 AK311006.1 AK316578.1 BC015186.1 BC063414.1 L25829.1 M21574.1 M30494.1 
    X76079.1 X95095.1 

    18 DOTS entries:

    DT.448233  DT.40293682  DT.91753879  DT.100788397  DT.101975351  DT.91753880  DT.91753891  DT.95269491 
    DT.424870  DT.100788396  DT.121259196  DT.121259214  DT.100654088  DT.121259206  DT.95305194  DT.121259225 
    DT.70104408  DT.99977868 

    Selected AceView cDNA sequences (see all 240):

    CN483903 F02116 F03485 BM715043 N69055 F04824 F07234 AA207000 
    CA447048 BX480820 R81781 BQ446932 BU737962 AA969144 AA055050 BM706203 
    BC015186 W70251 F03514 BG939663 AI092636 BF196702 BM721602 AW272703 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                    -     -     -     -                                   -                                                     -                 -         
    SP2:                    -     -     -     -                                   -                                                     -                 -         
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -                                                                                                                     

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:  -           -     -                                             
    SP2:                                                                  
    SP3:  -                                                               
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for PDGFRA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PDGFRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTGGTGG
    PDGFRA Expression
    About this image


    PDGFRA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Oligodendrocyte Precursor Cells Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Spinal Cord (Nervous System)    fully expand to see all 10 entries
             Oligodendrocyte Precursor Cells Spinal Cord White Matter
             Neural stem cells
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Oligodendrocyte Precursor Cells dP3 Neural Domain
     
     Oligodendrocytes (Nervous System)    fully expand to see all 8 entries
             Oligodendrocyte progenitor cells
     
     Heart (Cardiovascular System)    fully expand to see all 7 entries
             Cardiac Fibroblasts Myocardium
             Dorsal Aorta
    PDGFRA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDGFRA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74615

    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Tissue specificity: Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts,
    smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDGFRA (see all 13): 
              Liver Cancer in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Notch Signaling Targets in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PDGFRA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDGFRA
    QuantiTect SYBR Green Assays in human, mouse, rat PDGFRA
    QuantiFast Probe-based Assays in human, mouse, rat PDGFRA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PDGFRA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdgfra1 , 5 platelet derived growth factor receptor, alpha polypeptide1, 5 86.47(n)1
    91.83(a)1
      5 (39.55 cM)5
    185951  NM_001083316.11  NP_001076785.11 
     751522915 
    chicken
    (Gallus gallus)
    Aves PDGFRA1 platelet-derived growth factor receptor, alpha polypeptide 75.84(n)
    80.57(a)
      395509  NM_204749.1  NP_990080.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDGFRA6
    platelet-derived growth factor receptor, alpha pol...
    77(a)
    1 ↔ 1
    5(104062109-104109091)
    African clawed frog
    (Xenopus laevis)
    Amphibia pdgfra-prov2 platelet derived growth factor receptor, alpha polypeptide 76.73(n)    BC043948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdgfra2 platelet derived growth factor receptor alpha 78.74(n)   30745  AF200951.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R09D1.123
    C24G6.21
    tyrosine-protein kinase (KIN15/KIN16
    subfamily)3
    C24G6.21
    45(a)
    (best of 2)3
    49.72(n)1
    42.19(a)1
      II(9450033-9451702)3
    1789361  NM_072058.31  NP_504459.11 


    ENSEMBL Gene Tree for PDGFRA (if available)
    TreeFam Gene Tree for PDGFRA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for PDGFRA gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  RET2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    5 SIMAP similar genes for PDGFRA using alignment to 5 protein entries:     PGFRA_HUMAN (see all proteins):
    CSF1R    EPHA2    KIT    PDGFRB    FLT3

    Find genes that share paralogs with PDGFRA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDGFRA (see all 1687)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420364
    A metastatic melanoma sample4--see VAR_0420362 E K mis40--------
    VAR_0420374
    A lung neuroendocrine carcinoma sample4--see VAR_0420372 D N mis40--------
    VAR_0420354
    A glioblastoma multiforme sample4--see VAR_0420352 G R mis40--------
    VAR_0664744
    Gastrointestinal stromal tumor (GIST)4--see VAR_0664742 Y C mis40--------
    rs1219085861,2
    Cpathogenic155043404(+) GAGGGA/TCATTG 2 D V mis10--------
    rs1219085881,2
    Cpathogenic155054474(+) TGCATG/TATTCG 2 D Y mis10--------
    rs1219085851,2
    Cother155054463(+) CAGAGA/TCATCA 2 D V mis10--------
    rs1996398401,2
    --51074643(+) TTTTT-/GTTTTT 1 -- int10--------
    rs679257811,2
    C--51092534(+) AAAAA-/AAA/AA
    AAAAAAAA
    AAAAA
    2 -- int1 cds11NA 2
    rs339412771,2
    C--51100096(+) CTATT-/ACAGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PDGFRA (55095264 - 55164414 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PDGFRA: --
    Human Gene Mutation Database (HGMD): PDGFRA
    Selected Site Specific Mutation Identification with PCR Assays for PDGFRA (see all 26):
    Cosmic IdAA Change
    12402p.M844_S847del
    12401p.D842_M844del
    12399p.D846Y
    42897p.C235Y
    13348p.G829R
    Selected Site Specific Cancer Mutation PCR Panels containing PDGFRA (see all 8):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Soft Tissue Tumors
    3 Copy Number PCR Panels containing PDGFRA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing PDGFRA
    DNA2.0 Custom Variant and Variant Library Synthesis for PDGFRA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 173490   
    OMIM disorders: 606764  607685  
    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
  • Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome.
    Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    Mutations that cause overexpression and/or constitutive activation of PDGFRA may be a cause of hypereosinophilic
    syndrome
  • Gastrointestinal stromal tumor (GIST) [MIM:606764]: Common mesenchymal neoplasms arising in the
    gastrointestinal tract, most often in the stomach. They are histologically, immunohistochemically, and
    genetically different from typical leiomyomas, leiomyosarcomas, and schwannomas. Most GISTs are composed of a
    fairly uniform population of spindle-shaped cells. Some tumors are dominated by epithelioid cells or contain a
    mixture of spindle and epithelioid morphologies. Primary GISTs in the gastrointestinal tract commonly metastasize
    in the omentum and mesenteries, often as multiple nodules. However, primary tumors may also occur outside of the
    gastrointestinal tract, in other intra-abdominal locations, especially in the omentum and mesentery. Note=The
    gene represented in this entry may be involved in disease pathogenesis. Mutations causing PDGFRA constitutive
    activation have been found in gastrointestinal stromal tumors lacking KIT mutations (PubMed:12522257)

  • Selected diseases for PDGFRA (see all 40):    
    About MalaCards
    hypereosinophilic syndrome    gastrointestinal stromal tumor, somatic    fibrosarcoma of bone    myeloid neoplasm associated with pdgfra rearrangement
    cervical adenosquamous carcinoma    hypereosinophilic syndrome, idiopathic, resistant to imatinib    mixed glioma    reticular perineurioma
    gastrointestinal stromal tumor, familial    gastric leiomyosarcoma    mesenchymal cell neoplasm    leukemia, acute lymphoblastic 3
    adenosquamous carcinoma    gastrointestinal stromal tumor    carney triad    choroid plexus carcinoma
    rosai-dorfman disease    neurofibroma    desmoid tumor    pulmonary vein stenosis

    12 diseases from the University of Copenhagen DISEASES database for PDGFRA:
    Gastrointestinal stromal tumor     Eosinophilia     Mastocytosis     Leukemia
    Mesenchymal cell neoplasm     Malignant glioma     Endomyocardial fibrosis     Chondroma
    Sarcoma     Leiomyosarcoma     Neurofibromatosis     Myelofibrosis

    Find genes that share disorders with PDGFRA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PDGFRA gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrointestinal stromal tumor 95.8 173 18657298 (4), 20096441 (3), 16630479 (2), 17638656 (2) (see all 99)
    leukemia eosinophilic 87.3 12 16418325 (1), 16498388 (1), 15995324 (1), 19210352 (1) (see all 9)
    hypereosinophilic syndrome 86.9 19 12842979 (1), 16418325 (1), 17634706 (1), 16965435 (1) (see all 16)
    carney triad 82.4 4 17193822 (1), 17549339 (1), 18312355 (1), 17021135 (1)
    idiopathic hypereosinophilic syndrome 73.9 6 16343267 (1), 19176456 (1), 15772698 (1), 12660384 (1)
    idiopathic eosinophilia 73.7 2 16610578 (1)
    myeloproliferative neoplasm 70.6 8 20107158 (2), 18971950 (1), 19175693 (1), 20126996 (1)
    tumors 67.9 305 8548759 (6), 18758297 (4), 17527083 (4), 20393746 (4) (see all 99)
    mastocytosis systemic 66.4 9 16610578 (1), 12676775 (1), 15995325 (1), 15036941 (1)
    neurofibromatosis type 1 65.4 10 15540118 (2), 16143881 (1), 17193822 (1), 18671247 (1) (see all 8)

    Genetic Association Database (GAD): PDGFRA
    Human Genome Epidemiology (HuGE) Navigator: PDGFRA (58 documents)
    Tumor Gene Database (TGDB): PDGFRA

    Export disorders for PDGFRA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDGFRA gene, integrated from 10 sources (see all 820):
    (articles sorted by number of sources associating them with PDGFRA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. (PubMed id 15928335)1, 2, 7, 9 Corless C.L.... Heinrich M.C. (J. Clin. Oncol. 2005)
    2. Variant in promoter region of platelet-derived growth factor receptor-alpha (PDGFRalpha) gene is associated with the severity and allergic status of childhood asthma. (PubMed id 16804324)1, 4, 9 Wu L.S....Wang J.Y. (Int. Arch. Allergy Immunol. 2006)
    3. Detection of c-KIT and PDGFRA gene mutations in gastrointestinal stromal tumors: comparison of DHPLC and DNA sequencing methods using a single population-based cohort. (PubMed id 20023271)1, 4, 9 Battochio A....Lai R. (Am. J. Clin. Pathol. 2010)
    4. Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. (PubMed id 19563658)1, 4, 9 Longatto-Filho A....Reis R.M. (BMC Cancer 2009)
    5. Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity. (PubMed id 15894928)1, 7, 9 Yi E.S....Weidner N. (amp 2005)
    6. Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection. (PubMed id 19291337)1, 4, 9 Hou Y.Y....Frilling A. (J. Gastrointest. Surg. 2009)
    7. Spectrum and prognostication of KIT and PDGFRA mutation in gastrointestinal stromal tumors. (PubMed id 17532173)1, 4, 9 Tzen C.Y....Mau B.L. (Eur J Surg Oncol 2008)
    8. The analysis of status and clinical implication of KIT and PDGFRA mutations in gastrointestinal stromal tumor (GIST). (PubMed id 18618605)1, 4, 9 Du C.Y....Zhao G. (J Surg Oncol 2008)
    9. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. (PubMed id 8188664)1, 2, 9 Vassbotn F.S.... Holmsen H. (J. Biol. Chem. 1994)
    10. Interaction of PDGFRA promoter haplotypes and maternal environmental exposures in the risk of spina bifida. (PubMed id 19215021)1, 4, 9 Toepoel M....van Zoelen E.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5156 HGNC: 8803 AceView: PDGFRA Ensembl:ENSG00000134853 euGenes: HUgn5156
    ECgene: PDGFRA Kegg: 5156 H-InvDB: PDGFRA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDGFRA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFRA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDGFRA gene:
    Search GeneIP for patents involving PDGFRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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