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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDGFRA Gene

protein-coding   GIFtS: 76
GCID: GC04P055095

Platelet-Derived Growth Factor Receptor, Alpha Polypeptide

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Platelet-Derived Growth Factor Receptor, Alpha Polypeptide1 2     EC 2.7.10.13 8
Alpha-Type Platelet-Derived Growth Factor Receptor2 3     CD140A2
Platelet-Derived Growth Factor Receptor 22 3     PDGFRA/BCR Fusion2
PDGF-R-alpha2 3     Platelet-Derived Growth Factor Receptor Alpha2
PDGFR-22 3     Rearranged-In-Hypereosinophilia-Platelet Derived Growth Factor Receptor
Alpha Fusion Protein2
PDGFR22 3     PDGFR-alpha3
RHEPDGFRA2 3     Alpha Platelet-Derived Growth Factor Receptor3
CD140 Antigen-Like Family Member A2 3     Platelet-Derived Growth Factor Alpha Receptor3
CD140a Antigen2 3     EC 2.7.108

External Ids:    HGNC: 88031   Entrez Gene: 51562   Ensembl: ENSG000001348537   OMIM: 1734905   UniProtKB: P162343   

Export aliases for PDGFRA gene to outside databases

Previous GC identifers: GC04P054806 GC04P055065 GC04P054945 GC04P055010 GC04P054936 GC04P051043


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDGFRA Gene:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor
family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor
bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed
of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays
a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated
with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety
of other cancers. (provided by RefSeq, Mar 2012)

GeneCards Summary for PDGFRA Gene: 
PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) is a protein-coding gene. Diseases associated with PDGFRA include hypereosinophilic syndrome, and eosinophilic disorders, and among its related super-pathways are Glioma and Focal Adhesion. GO annotations related to this gene include platelet-derived growth factor receptor binding and protein homodimerization activity. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an
essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending
on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the
differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and
cephalic closure during embryonic development. Required for normal development of the mucosa lining the
gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.
Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of
agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands -
homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the
activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated
by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation
of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates
PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1
signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by
protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid
internalization of the activated receptor

summary for PDGFRA Gene:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFRA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022853.15  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDGFRA gene promoter:
         Max1   MAZR   AML1a   YY1   GATA-1   c-Rel   SRY   COMP1   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDGFRA promoter sequence
   Search SABiosciences Chromatin IP Primers for PDGFRA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

PDGFRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFRA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P055095:  view genomic region     (about GC identifiers)

Start:
55,095,264 bp from pter      End:
55,164,414 bp from pter
Size:
69,151 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234 (See protein sequence)
Recommended Name: Platelet-derived growth factor receptor alpha precursor  
Size: 1089 amino acids; 122670 Da
Subunit: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB.
Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor
dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine
phosphorylated) with SHB (via SH2 domain) (By similarity). Interacts (tyrosine phosphorylated) with SHF (via SH2
domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with
PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with
CRK, GRB2 and GRB7. Interacts with human cytomegalovirus/HHV-5 envelop glycoprotein B/gB
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly
internalized and degraded
Sequence caution: Sequence=AAP69563.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for PDGFRA:
1GQ5 (3D)    
Secondary accessions: B2RE69 E9PBH0 Q6P4H5 Q96KZ7 Q9UD28
Alternative splicing: 3 isoforms:  P16234-1   P16234-2   P16234-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDGFRA: NX_P16234

Explore proteomics data for PDGFRA at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • UniProtKB: Ubiquitinated, leading to its degradation (Probable)
  • UniProtKB: Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit
    of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and
    Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for
    interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at
    Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and
    Tyr-1018 is important for interaction with PLCG1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16234

  • 4/39 DME Specific Peptides for PDGFRA (P16234) (see all 39)
     QVARGME  RDLAARN  LGGTPYP  RSYVILS 

    PDGFRA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDGFRA Protein Expression
    REFSEQ proteins: NP_006197.1  
    ENSEMBL proteins: 
     ENSP00000257290   ENSP00000425648   ENSP00000425626   ENSP00000424218   ENSP00000425902  
     ENSP00000426472   ENSP00000425232  
    Reactome Protein details: P16234
    Human Recombinant Protein Products for PDGFRA: 
    EMD Millipore Purified and/or Recombinant PDGFRA Protein
    R&D Systems Recombinant & Natural Proteins for PDGFRA (PDGF R alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PDGFRA
    OriGene Protein Over-expression Lysate for PDGFRA
    OriGene MassSpec for PDGFRA 
    OriGene Custom Protein Services for PDGFRA
    GenScript Custom Purified and Recombinant Proteins Services for PDGFRA
    Novus Biologicals PDGFRA Proteins
    Novus Biologicals PDGFRA Lysate
    Sino Biological Recombinant Protein for PDGFRA
    Sino Biological Cell Lysate for PDGFRA 
    ProSpec Recombinant Protein for PDGFRA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA2536956
    GO:0009897external side of plasma membrane IEA--

    PDGFRA for ontologies           About GeneDecksing



    PDGFRA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFRA
    R&D Systems Antibodies for PDGFRA (PDGF R alpha)
    Cell Signaling Technology (CST) Antibodies for PDGFRA 
    OriGene Antibodies for PDGFRA
    OriGene Custom Antibody Services for PDGFRA
    GenScript Custom Superior Antibodies Services for PDGFRA
    Novus Biologicals PDGFRA Antibodies
    Abcam antibodies for PDGFRA
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PDGFRA
    LSBio Antibodies in human, mouse, rat for PDGFRA 

    Assay Products for PDGFRA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDGFRA
    R&D Systems ELISAs for PDGFRA (PDGF R alpha)         (see all)
    GenScript Custom Assay Services for PDGFRA
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PDGFRA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: platelet-derived growth factor receptor, alpha polypeptide 
    PDGF (platelet-derived growth factor) receptor family
    PDGF (platelet-derived growth factor) receptor family

    5/15 InterPro protein domains (see all 15):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR009134 Tyr_kinase_VEGFR_rcpt_N

    Graphical View of Domain Structure for InterPro Entry P16234

    ProtoNet protein and cluster: P16234

    4 Blocks protein domains:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature


    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    PDGFRA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGFRA_HUMAN, P16234
    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an
    essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending
    on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the
    differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and
    cephalic closure during embryonic development. Required for normal development of the mucosa lining the
    gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.
    Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of
    agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands -
    homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the
    activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated
    by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation
    of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol
    1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates
    PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1
    signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
    activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by
    protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid
    internalization of the activated receptor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or
    PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib,
    nilotinib and sorafenib

         Genatlas biochemistry entry for PDGFRA:
    platelet-derived growth factor receptor,alpha,growth arrest specific gene (gas),subunit,homodimerizing and
    heterodimerizing with PDGFRB,immunoglobulin superfamily

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA1646396
    GO:0005018platelet-derived growth factor alpha-receptor activity IMP2554309
    GO:0005021vascular endothelial growth factor-activated receptor activity IDA17470632
         
    PDGFRA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PDGFRA:
     Decreased viability  Increased colony dispersion (i 

         15/24 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Pdgfra) (see all 24):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 

    PDGFRA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PDGFRA: Pdgfratm2Sor Pdgfratm1Sor

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDGFRA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDGFRA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDGFRA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDGFRA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDGFRA:
    hsa-let-7b (MIRT004955)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFRA
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFRA (see all 98):
    hsa-miR-140-5p hsa-miR-642a hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PDGFRA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFRA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDGFRA
    Sirion Biotech Customized adenovirus for overexpression of PDGFRA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PDGFRA (see all 9)
    OriGene ORF clones in mouse, rat for PDGFRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDGFRA (NM_006206)
    Sino Biological Human cDNA Clone for PDGFRA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRA
    Sirion Biotech Customized lentivirus for stable overexpression of PDGFRA 
                         Customized lentivirus expression plasmids for stable overexpression of PDGFRA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDGFRA
    LifeMap BioReagents: cell line associated with PDGFRA: PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDGFRA About   (see all 55)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Melanoma0.43
    Signaling Pathways in Glioblastoma0.36
    2Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    3Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    4PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for PDGFRA (see all 6)
        Transcription PPAR Pathway
    Selected targets of Oct-3/4
    Development PDGF signaling via MAPK cascades
    Development PDGF signaling via STATs and NF-kB
    Signal transduction IP3 signaling

    1 R&D Systems Pathway for PDGFRA
        Akt Signaling Pathway

    5/58 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDGFRA (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for PDGFRA
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for PDGFRA
        Akt Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for PDGFRA
        Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Transcription PPAR Pathway
    Development PDGF signaling via MAPK cascades
    Signal transduction IP3 signaling

    5/9 BioSystems Pathways for PDGFRA (see all 9)
        Angiogenesis
    Focal Adhesion
    Signaling Pathways in Glioblastoma
    Cardiac Progenitor Differentiation
    Regulation of Actin Cytoskeleton


    5/31        Reactome Pathways for PDGFRA (see all 31)
        Signaling by EGFR in Cancer
    Disease
    Signaling by ERBB2
    GAB1 signalosome
    PI3K/AKT activation

    1 PharmGKB Pathway for PDGFRA
        Vemurafenib Pathway, Pharmacodynamics

    5/14         Kegg Pathways  (Kegg details for PDGFRA) (see all 14):
        MAPK signaling pathway
    Calcium signaling pathway
    Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway


    PDGFRA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDGFRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/109 Interacting proteins for PDGFRA (P162342, 3 ENSP000002572904) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461082, 3, ENSP000003005744MINT-8027048 MINT-8027033 MINT-8027093 I2D: score=4 STRING: ENSP00000300574
    CRKLP461092, 3, ENSP000003463004MINT-8027078 MINT-8027063 I2D: score=4 STRING: ENSP00000346300
    PLCG1P191742, 3, ENSP000002440074MINT-8033627 I2D: score=4 STRING: ENSP00000244007
    CAV1Q031353, ENSP000003391914I2D: score=3 STRING: ENSP00000339191
    PDGFAP040853, ENSP000003465084I2D: score=3 STRING: ENSP00000346508
    About this table

    Gene Ontology (GO): 5/56 biological process terms (GO ID links to tree view) (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001553luteinization ISS--
    GO:0001701in utero embryonic development IEA--
    GO:0001775cell activation TAS10508235
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----

    PDGFRA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDGFRA for compounds           About GeneDecksing

    EMD Millipore small molecules for PDGFRA:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDGFRA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    SU 16fPotent and selective PDGFRbeta inhibitor[251356-45-3]

    2 HMDB Compounds for PDGFRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 DrugBank Compounds for PDGFRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Becaplerminc-sis (see all 5)165101-51-9target--1702511 12632922 10070317 14506245 7665222
    ImatinibCGP-57148B (see all 4)152459-95-5targetantagonist15894928 15995325 15946589 15928335 15921304
    PazopanibGW-786034 (see all 2)444731-52-6targetinhibitor17288876
    Ponatinib -- 943319-70-8targetinhibitor19878872
    SunitinibSU011248 (see all 2)557795-19-4targetantagonist16638875
    Regorafenib-- 755037-03-7targetinhibitor--

    10/21 Novoseek inferred chemical compound relationships for PDGFRA gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 94.1 222 14645423 (5), 15928335 (4), 16294026 (3), 19013640 (3) (see all 99)
    sunitinib 81.8 13 19366796 (3), 17041096 (2), 17710208 (1), 17272980 (1) (see all 9)
    tyrosine 80.3 197 18478259 (3), 15750190 (2), 17452978 (2), 18084259 (2) (see all 99)
    pkc 412 68.8 4 12781364 (2), 17452978 (1), 17087936 (1)
    ag-1296 57.5 1 16439802 (1)
    vegf 35.7 27 18950958 (4), 18006812 (2), 19948069 (2), 15334938 (2) (see all 13)
    hydroxyurea 25.7 1 20010473 (1)
    rapamycin 23.1 1 17041096 (1)
    phosphatidylinositol 13.7 3 17452978 (1), 17141222 (1), 16186508 (1)
    phosphotyrosine 8.59 3 8188664 (1), 15677564 (1)

    Search CenterWatch for drugs/clinical trials and news about PDGFRA / PGFRA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDGFRA gene: 
    NM_006206.4  

    Unigene Cluster for PDGFRA:

    Platelet-derived growth factor receptor, alpha polypeptide
    Hs.74615  [show with all ESTs]
    Unigene Representative Sequence: NM_006206
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257290(uc003haa.3 uc003han.4) ENST00000508170(uc003hal.3)
    ENST00000509092(uc010igq.1) ENST00000512143 ENST00000509490(uc003ham.2)
    ENST00000503856 ENST00000504461 ENST00000512522 ENST00000461294 ENST00000507536(uc003hao.1)


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    hsa-miR-140-5p hsa-miR-642a hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-342-3p hsa-miR-519a
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    OriGene clones in human, mouse for PDGFRA (see all 9)
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    Additional mRNA sequence: 

    AK308353.1 AK311006.1 AK316578.1 BC015186.1 BC063414.1 L25829.1 M21574.1 M30494.1 
    X76079.1 X95095.1 

    18 DOTS entries:

    DT.448233  DT.40293682  DT.91753879  DT.100788397  DT.101975351  DT.91753880  DT.91753891  DT.95269491 
    DT.424870  DT.100788396  DT.121259196  DT.121259214  DT.100654088  DT.121259206  DT.95305194  DT.121259225 
    DT.70104408  DT.99977868 

    24/240 AceView cDNA sequences (see all 240):

    W70251 AA207000 BG939663 BQ446932 AA969144 BU737962 AI092636 F03514 
    BC015186 BM715043 BM706203 CN483903 N69055 BF196702 CD518236 AA055050 
    H90646 F02116 CA447048 F03485 BM721602 R81781 AW272703 F04824 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PDGFRA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                    -     -     -     -                                   -                                                     -                 -         
    SP2:                    -     -     -     -                                   -                                                     -                 -         
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -                                                                                                                     

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:  -           -     -                                             
    SP2:                                                                  
    SP3:  -                                                               
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for PDGFRA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDGFRA expression in normal human tissues (normalized intensities)      PDGFRA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTGGTGG
    PDGFRA Expression
    About this image


    PDGFRA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/47 selected tissues (see all 47) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Oligodendrocyte Precursor Cells Cerebral Cortex
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 13 entries
             Cushion Mesenchymal Cells Endocardium
             Dorsal Aorta
             DKK1-induced cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 12 entries
             Oligodendrocyte Precursor Cells dP3 Neural Domain
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 8 entries
             Ureter
             Human Bladder Smooth Muscle Cells (HBdSMC)   
             visceral organ   
     
     Kidney (Urinary System)    fully expand to see all 8 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             S-shaped Body
             visceral organ/metanephros/renal medulla   

    See PDGFRA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDGFRA

    SOURCE GeneReport for Unigene cluster: Hs.74615

    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
    Tissue specificity: Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts,
    smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including PDGFRA (see all 13): 
              Liver Cancer in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Lineage Identification in human mouse rat
              Notch Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDGFRA gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdgfra1 , 5 platelet derived growth factor receptor, alpha polypeptide1, 5 86.47(n)1
    91.83(a)1
      5 (39.55 cM)5
    185951  NM_001083316.11  NP_001076785.11 
     751522915 
    chicken
    (Gallus gallus)
    Aves PDGFRA1 platelet-derived growth factor receptor, alpha polypeptide 75.84(n)
    80.57(a)
      395509  NM_204749.1  NP_990080.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDGFRA6
    Tyrosine-protein kinase receptor
    77(a)
    1 ↔ 1
    5(104062109-104109091)
    African clawed frog
    (Xenopus laevis)
    Amphibia pdgfra-prov2 platelet derived growth factor receptor, alpha polypeptide 76.73(n)    BC043948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdgfra2 platelet derived growth factor receptor alpha 78.74(n)   30745  AF200951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32773 protein amino acid phosphorylation
    protein tyrosine more
    32(a)   23E3   --


    ENSEMBL Gene Tree for PDGFRA (if available)
    TreeFam Gene Tree for PDGFRA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDGFRA gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  RET2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    5 SIMAP similar genes for PDGFRA using alignment to 5 protein entries:     PGFRA_HUMAN (see all proteins):
    CSF1R    EPHA2    KIT    PDGFRB    FLT3

    PDGFRA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1687 SNPs in PDGFRA are shown (see all 1687)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420364
    A metastatic melanoma sample4--see VAR_0420362 E K mis40--------
    VAR_0420374
    A lung neuroendocrine carcinoma sample4--see VAR_0420372 D N mis40--------
    VAR_0420354
    A glioblastoma multiforme sample4--see VAR_0420352 G R mis40--------
    VAR_0664744
    Gastrointestinal stromal tumor (GIST)4--see VAR_0664742 Y C mis40--------
    rs1219085861,2
    Cpathogenic155043404(+) GAGGGA/TCATTG 2 D V mis10--------
    rs1219085881,2
    Cpathogenic155054474(+) TGCATG/TATTCG 2 D Y mis10--------
    rs1219085851,2
    Cother155054463(+) CAGAGA/TCATCA 2 D V mis10--------
    VAR_0664754
    ----see VAR_0664752 Y S mis40--------
    VAR_0664644
    ----see VAR_0664642 H R mis40--------
    VAR_0664634
    ----see VAR_0664632 I M mis40--------

    HapMap Linkage Disequilibrium report for PDGFRA (55095264 - 55164414 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PDGFRA: --

    Human Gene Mutation Database (HGMD): PDGFRA
    5/26 SABiosciences Cancer Mutation PCR Assays for PDGFRA (see all 26):
    Cosmic IdAA Change
    12402p.M844_S847del
    12401p.D842_M844del
    12399p.D846Y
    42897p.C235Y
    13348p.G829R
    5/8 SABiosciences Cancer Mutation PCR Arrays containing PDGFRA (see all 8):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Soft Tissue Tumors
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing PDGFRA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing PDGFRA
    DNA2.0 Custom Variant and Variant Library Synthesis for PDGFRA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173490   
    OMIM disorders: 606764  607685  
    UniProtKB/Swiss-Prot: PGFRA_HUMAN, P16234
  • Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome.
    Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    Mutations that cause overexpression and/or constitutive activation of PDGFRA may be a cause of hypereosinophilic
    syndrome
  • Gastrointestinal stromal tumor (GIST) [MIM:606764]: Common mesenchymal neoplasms arising in the
    gastrointestinal tract, most often in the stomach. They are histologically, immunohistochemically, and
    genetically different from typical leiomyomas, leiomyosarcomas, and schwannomas. Most GISTs are composed of a
    fairly uniform population of spindle-shaped cells. Some tumors are dominated by epithelioid cells or contain a
    mixture of spindle and epithelioid morphologies. Primary GISTs in the gastrointestinal tract commonly metastasize
    in the omentum and mesenteries, often as multiple nodules. However, primary tumors may also occur outside of the
    gastrointestinal tract, in other intra-abdominal locations, especially in the omentum and mesentery. Note=The
    gene represented in this entry may be involved in disease pathogenesis. Mutations causing PDGFRA constitutive
    activation have been found in gastrointestinal stromal tumors lacking KIT mutations (PubMed:12522257)

  • 20/159 diseases for PDGFRA (see all 159):    About MalaCards
    hypereosinophilic syndrome    eosinophilic disorders    fibrosarcoma of bone    myeloid neoplasm associated with pdgfra rearrangement
    gastrointestinal stromal tumor, somatic    gastrointestinal stromal tumor    cervical adenosquamous carcinoma    reticular perineurioma
    gastric leiomyosarcoma    mixed glioma    hypereosinophilic syndrome, idiopathic, resistant to imatinib    adenosquamous carcinoma
    carney triad    desmoid tumor    fibrosarcoma    neurofibroma
    choroid plexus carcinoma    rosai-dorfman disease    sarcomatoid renal cell carcinoma    pediatric osteosarcoma

    12 diseases from the University of Copenhagen DISEASES database for PDGFRA:
    Gastrointestinal stromal tumor     Eosinophilia     Mastocytosis     Leukemia
    Mesenchymal cell neoplasm     Malignant glioma     Endomyocardial fibrosis     Chondroma
    Sarcoma     Leiomyosarcoma     Neurofibromatosis     Myelofibrosis

    PDGFRA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for PDGFRA gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrointestinal stromal tumor 95.8 173 18657298 (4), 20096441 (3), 16630479 (2), 17638656 (2) (see all 99)
    leukemia eosinophilic 87.3 12 16418325 (1), 16498388 (1), 15995324 (1), 19210352 (1) (see all 9)
    hypereosinophilic syndrome 86.9 19 12842979 (1), 16418325 (1), 17634706 (1), 16965435 (1) (see all 16)
    carney triad 82.4 4 17193822 (1), 17549339 (1), 18312355 (1), 17021135 (1)
    idiopathic hypereosinophilic syndrome 73.9 6 16343267 (1), 19176456 (1), 15772698 (1), 12660384 (1)
    idiopathic eosinophilia 73.7 2 16610578 (1)
    myeloproliferative neoplasm 70.6 8 20107158 (2), 18971950 (1), 19175693 (1), 20126996 (1)
    tumors 67.9 305 8548759 (6), 18758297 (4), 17527083 (4), 20393746 (4) (see all 99)
    mastocytosis systemic 66.4 9 16610578 (1), 12676775 (1), 15995325 (1), 15036941 (1)
    neurofibromatosis type 1 65.4 10 15540118 (2), 16143881 (1), 17193822 (1), 18671247 (1) (see all 8)

    Genetic Association Database (GAD): PDGFRA
    Human Genome Epidemiology (HuGE) Navigator: PDGFRA (58 documents)
    Tumor Gene Database (TGDB): PDGFRA

    Export disorders for PDGFRA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDGFRA gene, integrated from 9 sources (see all 801):
    (articles sorted by number of sources associating them with PDGFRA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. (PubMed id 15928335)1, 2, 7, 9 Corless C.L....Heinrich M.C. (2005)
    2. Variant in promoter region of platelet-derived growth factor receptor-alpha (PDGFRalpha) gene is associated with the severity and allergic status of childhood asthma. (PubMed id 16804324)1, 4, 9 Wu L.S....Wang J.Y. (2006)
    3. Detection of c-KIT and PDGFRA gene mutations in gastr ointestinal stromal tumors: comparison of DHPLC and DNA sequencing methods usin g a single population-based cohort. (PubMed id 20023271)1, 4, 9 Battochio A....Lai R. (2010)
    4. Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. (PubMed id 19563658)1, 4, 9 Longatto-Filho A....Reis R.M. (2009)
    5. Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity. (PubMed id 15894928)1, 7, 9 Yi E.S....Weidner N. (2005)
    6. Impact of KIT and PDGFRA Gene Mutations on Prognosis of Patients with Gastrointestinal Stromal Tumors After Complete Primary Tumor Resection. (PubMed id 19291337)1, 4, 9 Hou Y.Y....Frilling A. (2009)
    7. Spectrum and prognostication of KIT and PDGFRA mutation in gastrointestinal stromal tumors. (PubMed id 17532173)1, 4, 9 Tzen C.Y....Mau B.L. (2008)
    8. The analysis of status and clinical implication of KIT and PDGFRA mutations in gastrointestinal stromal tumor (GIST). (PubMed id 18618605)1, 4, 9 Du C.Y....Zhao G. (2008)
    9. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. (PubMed id 8188664)1, 2, 9 Vassbotn F.S....Holmsen H. (1994)
    10. Interaction of PDGFRA promoter haplotypes and maternal environmental exposures in the risk of spina bifida. (PubMed id 19215021)1, 4, 9 Toepoel M....van Zoelen E.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5156 HGNC: 8803 AceView: PDGFRA Ensembl:ENSG00000134853 euGenes: HUgn5156
    ECgene: PDGFRA Kegg: 5156 H-InvDB: PDGFRA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDGFRA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFRA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDGFRA gene:
    Search GeneIP for patents involving PDGFRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for PDGFRA (PDGF R alpha)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
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     OriGene ORF clones in mouse, rat for PDGFRA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDGFRA   OriGene Custom Protein Services for PDGFRA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDGFRA
     QIAGEN SeqTarget long-range PCR primers for resequencing PDGFRA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFRA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFRA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFRA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDGFRA
     GenScript Custom Purified and Recombinant Proteins Services for PDGFRA GenScript cDNA clones with any tag delivered in your preferred vector for PDGFRA
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     SABiosciences PCR Arrays including human, mouse, rat PDGFRA
     Tocris compounds for PDGFRA
     Proteins and Antibodies for PDGFRA
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for PDGFRA
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PDGFRA




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Cell Line associated with PDGFRA: PureStem 4D20.8, NCr-fac Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFRA
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PDGFRA
     SwitchGear Promoter luciferase reporter plasmids for PDGFRA
     ThermoFisher Antibodies for PDGFRA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFRA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PDGFRA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDGFRA
    Customized:
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     lentivirus expression plasmids for stable overexpression of PDGFRA
     adenovirus for overexpression of PDGFRA
     LSBio Antibodies in human, mouse, rat for PDGFRA
    Customized transgenic rodents for:
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     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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