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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDGFD Gene

protein-coding   GIFtS: 64
GCID: GC11M103777

Platelet Derived Growth Factor D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Platelet Derived Growth Factor D1 2     Spinal Cord-Derived Growth Factor B2 3
IEGF2 3 5     PDGF-D2 3
SCDGFB2 3 5     SCDGF-B2 3
Spinal Cord Derived Growth Factor B1 2     Platelet-Derived Growth Factor D2
Iris-Expressed Growth Factor2 3     Spinal Cord-Derived Growth Factor-B2

External Ids:    HGNC: 306201   Entrez Gene: 803102   Ensembl: ENSG000001709627   OMIM: 6096735   UniProtKB: Q9GZP03   

Export aliases for PDGFD gene to outside databases

Previous GC identifers: GC11M103315 GC11M103283 GC11M099706


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDGFD Gene:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of
this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight
cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does
not dimerize with the other three family members. It differs from alpha and beta members of this family in having
an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for PDGFD Gene: 
PDGFD (platelet derived growth factor D) is a protein-coding gene. Diseases associated with PDGFD include mesangial proliferative glomerulonephritis, and proliferative glomerulonephritis, and among its related super-pathways are Focal Adhesion and Glioma. GO annotations related to this gene include growth factor activity. An important paralog of this gene is PDGFC.

UniProtKB/Swiss-Prot: PDGFD_HUMAN, Q9GZP0
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell
proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an
important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood
vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative
glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By
similarity)

summary for PDGFD Gene:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDGFD gene promoter:
         TBP   NF-1   NF-1/L   Nkx2-5   MEF-2A   AREB6   aMEF-2   Msx-1   MRF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDGFD promoter sequence
   Search SABiosciences Chromatin IP Primers for PDGFD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

PDGFD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M103777:  view genomic region     (about GC identifiers)

Start:
103,777,914 bp from pter      End:
104,035,107 bp from pter
Size:
257,194 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDGFD_HUMAN, Q9GZP0 (See protein sequence)
Recommended Name: Platelet-derived growth factor D precursor  
Size: 370 amino acids; 42848 Da
Subunit: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and
PDGFRB
Subcellular location: Secreted. Note=Released by platelets upon wounding
Developmental stage: Not detectable in the earliest stages of glomerulogenesis, and not detected in the
metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis, localized
to epithelial cells transitioning from the early developing nephrons of the comma- and S-shaped stages to the
visceral epithelial cells of differentiated glomeruli. In the developing pelvis, expressed at the basement
membrane of immature collecting ducts and by presumptive fibroblastic cells in the interstitium
Secondary accessions: A8K9T6 Q9BWV5
Alternative splicing: 2 isoforms:  Q9GZP0-1   Q9GZP0-2   

Explore the universe of human proteins at neXtProt for PDGFD: NX_Q9GZP0

Explore proteomics data for PDGFD at MOPED 

Post-translational modifications:

  • UniProtKB: Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is
    necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by
    urokinase plasminogen activator gives rise to the active form
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZP0

  • PDGFD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDGFD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_079484.1  NP_149126.1  

    ENSEMBL proteins: 
     ENSP00000376865   ENSP00000302193   ENSP00000432909  
    Reactome Protein details: Q9GZP0
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    Novus Biologicals PDGFD Lysates
    Sino Biological Recombinant Protein for PDGFD
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    ProSpec Recombinant Protein for PDGFD
    Cloud-Clone Corp. Proteins for PDGFD 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0016020membrane ----

    PDGFD for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027123 PDGFD
     IPR000859 CUB_dom
     IPR000072 PD_growth_factor

    Graphical View of Domain Structure for InterPro Entry Q9GZP0

    ProtoNet protein and cluster: Q9GZP0

    2 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB000859 CUB domain


    UniProtKB/Swiss-Prot: PDGFD_HUMAN, Q9GZP0
    Similarity: Belongs to the PDGF/VEGF growth factor family
    Similarity: Contains 1 CUB domain


    PDGFD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDGFD_HUMAN, Q9GZP0
    Function: Growth factor that plays an essential role in the regulation of embryonic development, cell
    proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an
    important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood
    vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative
    glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005161platelet-derived growth factor receptor binding IEA--
    GO:0008083growth factor activity IEA--
         
    PDGFD for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Pdgfd (no phenotypes)

    PDGFD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdgfdtm1Lex for PDGFD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDGFD 
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    SwitchGear 3'UTR luciferase reporter plasmidPDGFD 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDGFD About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2Glioma
    Melanoma0.43
    Prostate cancer0.39
    3Signaling by FGFR
    Signaling by PDGF0.85
    4Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.57
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PDGFD
        Development PDGF signaling via MAPK cascades
    Cytoskeleton remodeling Role of PDGFs in cell migration


    2 GeneGo (Thomson Reuters) Pathways for PDGFD
        Cytoskeleton remodeling Role of PDGFs in cell migration
    Development PDGF signaling via MAPK cascades

    1 BioSystems Pathway for PDGFD
        Focal Adhesion


    2        Reactome Pathways for PDGFD
        Signal Transduction
    Signaling by PDGF


    5/6         Kegg Pathways  (Kegg details for PDGFD) (see all 6):
        PI3K-Akt signaling pathway
    Focal adhesion
    Gap junction
    Regulation of actin cytoskeleton
    Prostate cancer


    PDGFD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDGFD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for PDGFD (Q9GZP03 ENSP000003768654) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFRBP096193, ENSP000002617994I2D: score=1 STRING: ENSP00000261799
    PDGFRAENSP000002572904STRING: ENSP00000257290
    PLATENSP000002208094STRING: ENSP00000220809
    PLAUENSP000003618504STRING: ENSP00000361850
    PLAURENSP000003393284STRING: ENSP00000339328
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0050730regulation of peptidyl-tyrosine phosphorylation IEA--
    GO:0051781positive regulation of cell division IEA--
    GO:0071230cellular response to amino acid stimulus IEA--

    PDGFD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDGFD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    SU 16fPotent and selective PDGFRbeta inhibitor[251356-45-3]

    Search CenterWatch for drugs/clinical trials and news about PDGFD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDGFD gene (2 alternative transcripts): 
    NM_025208.4  NM_033135.3  

    Unigene Cluster for PDGFD:

    Platelet derived growth factor D
    Hs.352298  [show with all ESTs]
    Unigene Representative Sequence: BC030645
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393158 ENST00000302251(uc001php.3 uc001phq.3) ENST00000529268

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    Additional mRNA sequence: 

    AB033832.1 AF113216.1 AF335584.1 AF336376.1 AK292801.1 AY027517.1 AY027518.1 AY359116.1 
    BC030645.2 

    4 DOTS entries:

    DT.211370  DT.100033675  DT.99932823  DT.120725526 

    24/94 AceView cDNA sequences (see all 94):

    AA620703 NM_033135 AF113216 NM_025208 AI962915 BM667348 BQ575044 BM710630 
    AI631061 AA778655 BQ182229 BP872435 AA448806 AA808265 AA620733 BQ003700 
    AI079299 AA620856 AW271765 BU431765 AI005125 BE018544 BC030645 AA488996 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PDGFD    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:        -                                             


    ECgene alternative splicing isoforms for PDGFD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDGFD expression in normal human tissues (normalized intensities)      PDGFD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PDGFD Expression
    About this image


    PDGFD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal cortex   
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem Z11, Meso Progenitor
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Keratocyte (HK)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells

    See PDGFD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDGFD

    SOURCE GeneReport for Unigene cluster: Hs.352298

    UniProtKB/Swiss-Prot: PDGFD_HUMAN, Q9GZP0
    Tissue specificity: Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in
    placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the
    visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle
    cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area.
    Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive
    nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle
    cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of
    atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland
    while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and
    brain cancer-derived cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including PDGFD: 
              Angiogenic Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PDGFD gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdgfd1 , 5 platelet-derived growth factor, D polypeptide1, 5 85.86(n)1
    85.14(a)1
      9 (2.46 cM)5
    717851  NM_027924.21  NP_082200.11 
     61686125 
    chicken
    (Gallus gallus)
    Aves PDGFD1 platelet derived growth factor D 79.23(n)
    81.15(a)
      418978  XM_417172.2  XP_417172.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDGFD6
    platelet derived growth factor D
    59(a)
    1 ↔ 1
    3(191399725-191598474)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005357181 platelet-derived growth factor D-like 66.45(n)
    69.64(a)
      100535718  XM_003200098.1  XP_003200146.1 


    ENSEMBL Gene Tree for PDGFD (if available)
    TreeFam Gene Tree for PDGFD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDGFD gene
    PDGFC2  
    3 SIMAP similar genes for PDGFD using alignment to 2 protein entries:     PDGFD_HUMAN (see all proteins):
    PDGFC    MASP1    NRP2

    PDGFD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5471 SNPs in PDGFD are shown (see all 5471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364184
    A colorectal cancer sample4--see VAR_0364182 D Y mis40--------
    rs106066951,2
    C--103689079(+) ttttt-/T/TTTT
            
    gagac
    2 -- int11NA 2
    rs8382431,2
    C,F,H--103777445(+) TTGGGG/AAACAA 2 -- ds50015Minor allele frequency- A:0.01NS NA 792
    rs1389287001,2
    C--103777453(+) CAAAG-/TGTTGTTC 2 -- ds50010--------
    rs1870402391,2
    C--103777453(+) CAAAGG/TGTTGT 2 -- ds50010--------
    rs1894590721,2
    C--103777461(+) TGTTCC/TTTCGG 2 -- ds50010--------
    rs1815159291,2
    --103777484(+) GAAGCC/TTTCAG 2 -- ds50010--------
    rs1852556141,2
    --103777598(+) AGTGCA/CGTGGC 2 -- ds50010--------
    rs1138757821,2
    C,F--103777611(+) GATCTC/TGGCTT 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1900147421,2
    --103777615(+) TCGGCC/TTACTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PDGFD (103777914 - 104027914 bp, first 250kb of PDGFD)

    Structural Variations
         Database of Genomic Variants (DGV) 10/30 variations for PDGFD (see all 30):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676733CNV Deletion23128226
    esv2745011CNV Deletion23290073
    esv3736CNV Deletion18987735
    esv3147CNV Deletion18987735
    esv2671461CNV Deletion23128226
    esv2666036CNV Deletion23128226
    esv1417082CNV Deletion17803354
    esv991768CNV Deletion20482838
    esv2597532CNV Deletion19546169
    esv2205640CNV Deletion18987734


    Human Gene Mutation Database (HGMD): PDGFD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PDGFD
    DNA2.0 Custom Variant and Variant Library Synthesis for PDGFD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609673    OMIM disorders: --

    11 diseases for PDGFD:    About MalaCards
    mesangial proliferative glomerulonephritis    proliferative glomerulonephritis    brain cancer    glomerulonephritis
    coronary heart disease    atherosclerosis    prostatitis    retinitis
    prostate cancer    melanoma    endotheliitis


    PDGFD for disorders           About GeneDecksing

    Genetic Association Database (GAD): PDGFD
    Human Genome Epidemiology (HuGE) Navigator: PDGFD (6 documents)

    Export disorders for PDGFD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDGFD gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with PDGFD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. (PubMed id 11162582)1, 2, 3, 9 Hamada T.... Miyata Y. (2001)
    2. Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer. (PubMed id 11980634)1, 2, 3 LaRochelle W.J....Lichenstein H.S. (2002)
    3. Platelet-derived growth factor-D expression in developing and mature human kidneys. (PubMed id 12427128)1, 2, 9 Changsirikulchai S.... Alpers C.E. (2002)
    4. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes. (PubMed id 11342471)1, 2, 9 Uutela M.... Alitalo K. (2001)
    5. Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Association of platelet-derived growth factor-D gene polymorphism with ischemic stroke in a Chinese case-control study. (PubMed id 18600092)1, 4 Han S.H....Nie S.F. (2008)
    9. Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. (PubMed id 15988036)1, 2 Ustach C.V. and Kim H.-R.C. (2005)
    10. PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. (PubMed id 15271796)1, 2 Uutela M.... Alitalo K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80310 HGNC: 30620 AceView: PDGFD Ensembl:ENSG00000170962 euGenes: HUgn80310
    ECgene: PDGFD Kegg: 80310 H-InvDB: PDGFD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDGFD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDGFD gene:
    Search GeneIP for patents involving PDGFD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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