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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDGFC Gene

protein-coding GIFtS: 64
GCID: GC04M157682

platelet derived growth factor C

Explore 34 diseases affiliated with
PDGFC via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Platelet Derived Growth Factor C¹ ²		Fallotein³
SCDGF¹ ² ³		FALLOTEIN²
Spinal Cord-Derived Growth Factor² ³		Platelet-Derived Growth Factor C²
PDGF-C² ³		Secretory Growth Factor-Like Protein²
VEGF-E² ³		Fallotein³

External Ids:	HGNC: 8801¹	Entrez Gene: 56034²	Ensembl: ENSG00000145431⁷	OMIM: 608452⁵	UniProtKB: Q9NRA1³

ORGUL members:
	NONCODE:n410166

Export aliases for PDGFC gene to outside databases

Previous GC identifers: GC04M158562 GC04M158113 GC04M158260 GC04M158040 GC04M157902 GC04M153433

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDGFC:

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this

family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines.

This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta

polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have

been found for this gene. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: PDGFC_HUMAN, Q9NRA1

Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation,

cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required

for normal skeleton formation during embryonic development, especially for normal development of the craniofacial

skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic

development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation,

proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in

fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition

occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the

maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function

summary for PDGFC:

Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine

kinase activity. They have roles in the regulation of many biological processes including embryonic

development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of

some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,

which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce

receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates

the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma

pathways.

Gene Wiki entry for PDGFC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDGFC gene promoter:
AhR C/EBPbeta Tal-1beta LCR-F1 C/EBPalpha Arnt E47 MEF-2A COMP1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDGFC promoter sequence

Search SABiosciences Chromatin IP Primers for PDGFC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32

PDGFC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFC gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M157682: view genomic region (about GC identifiers)

Start:	157,681,606 bp from pter	End:	157,892,546 bp from pter
Size:	210,941 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDGFC_HUMAN, Q9NRA1 (See protein sequence)

Recommended Name: Platelet-derived growth factor C precursor

Size: 345 amino acids; 39029 Da

Subunit: Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and

PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain)

Subcellular location: Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the

nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors

Developmental stage: In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the

undifferentiated mesenchyme (at protein level)

Miscellaneous: A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma

Secondary accessions: B9EGR8 Q4W5M9 Q9UL22

Alternative splicing: 3 isoforms: Q9NRA1-1 Q9NRA1-2 Q9NRA1-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDGFC: NX_Q9NRA1

Post-translational modifications:

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the

receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the

CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG¹

Sumoylated with SUMO1¹

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NRA1

PDGFC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057289.1

ENSEMBL proteins:

ENSP00000422464 ENSP00000274071 ENSP00000424600 ENSP00000410048 ENSP00000442943

ENSP00000439728

Reactome Protein details: Q9NRA1
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for PDGFC (PDGF-CC)
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	Novus Biologicals PDGFC Proteins Novus Biologicals PDGFC Lysate
	Sino Biological Recombinant Protein for PDGFC
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PDGFC

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	10806482
GO:0005634	nucleus	IEA	--
GO:0005788	endoplasmic reticulum lumen	TAS	--

PDGFC for ontologies About GeneDecksing

PDGFC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PDGFC (PDGF-C)
	OriGene Antibodies (see all 2): PDGFC OriGene Custom Antibody Services for PDGFC
	GenScript Custom Superior Antibodies Services for PDGFC
	Novus Biologicals PDGFC Antibodies
	Search for Antibodies for PDGFC at Abcam
	Uscn Antibodies for PDGFC
	Search ThermoFisher Antibodies for PDGFC

Assay Products for PDGFC:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for PDGFC (PDGF-CC)
	GenScript Custom Assay Services for PDGFC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PDGFC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDGFC for domains About GeneDecksing

2 InterPro domains/families:

IPR000859 CUB_dom

IPR000072 PD_growth_factor

Graphical View of Domain Structure for InterPro Entry Q9NRA1

ProtoNet protein and cluster: Q9NRA1

2 Blocks protein families:

IPB000072 Platelet-derived growth factor (PDGF)

IPB000859 CUB domain

UniProtKB/Swiss-Prot: PDGFC_HUMAN, Q9NRA1

Similarity: Belongs to the PDGF/VEGF growth factor family

Similarity: Contains 1 CUB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: