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Aliases for PDGFC Gene

Aliases for PDGFC Gene

  • Platelet Derived Growth Factor C 2 3
  • Spinal Cord-Derived Growth Factor 3 4
  • FALLOTEIN 3 4
  • PDGF-C 3 4
  • VEGF-E 3 4
  • SCDGF 3 4
  • Secretory Growth Factor-Like Protein 3
  • Platelet-Derived Growth Factor C 3

External Ids for PDGFC Gene

Summaries for PDGFC Gene

Entrez Gene Summary for PDGFC Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for PDGFC Gene

PDGFC (Platelet Derived Growth Factor C) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein homodimerization activity and platelet-derived growth factor receptor binding. An important paralog of this gene is PDGFD.

UniProtKB/Swiss-Prot for PDGFC Gene

  • Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Tocris Summary for PDGFC Gene

  • Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways.

Gene Wiki entry for PDGFC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFC Gene

Genomics for PDGFC Gene

Genomic Location for PDGFC Gene

Start:
156,760,454 bp from pter
End:
156,971,394 bp from pter
Size:
210,941 bases
Orientation:
Minus strand

Genomic View for PDGFC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDGFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFC Gene

Regulatory Elements for PDGFC Gene

Proteins for PDGFC Gene

  • Protein details for PDGFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA1-PDGFC_HUMAN
    Recommended name:
    Platelet-derived growth factor C
    Protein Accession:
    Q9NRA1
    Secondary Accessions:
    • B4DU34
    • B9EGR8
    • Q4W5M9
    • Q9UL22

    Protein attributes for PDGFC Gene

    Size:
    345 amino acids
    Molecular mass:
    39029 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain).
    Miscellaneous:
    • A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma

    Alternative splice isoforms for PDGFC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDGFC Gene

Proteomics data for PDGFC Gene at MOPED

Post-translational modifications for PDGFC Gene

  • N-glycosylated.
  • Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG
  • Sumoylated with SUMO1.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn25 and Asn55

Other Protein References for PDGFC Gene

No data available for DME Specific Peptides for PDGFC Gene

Domains for PDGFC Gene

Protein Domains for PDGFC Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRA1

UniProtKB/Swiss-Prot:

PDGFC_HUMAN
Domain:
  • Contains 1 CUB domain.:
    • Q9NRA1
Family:
  • Belongs to the PDGF/VEGF growth factor family.:
    • Q9NRA1
genes like me logo Genes that share domains with PDGFC: view

No data available for Gene Families for PDGFC Gene

Function for PDGFC Gene

Molecular function for PDGFC Gene

UniProtKB/Swiss-Prot Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
UniProtKB/Swiss-Prot Induction: Up-regulated by EWS-FLI1 chimeric transcription factor in tumor derived cells. Up-regulated in podocytes and interstitial cells after injury/activation of these cells. FGF2 activates PDGFC transcription via EGR1. Up-regulated by TGFB1 in concert with FGF2.

Gene Ontology (GO) - Molecular Function for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005161 platelet-derived growth factor receptor binding IPI 10806482
GO:0005515 protein binding IPI 10806482
GO:0008083 growth factor activity IEA --
GO:0042803 protein homodimerization activity IPI 10806482
genes like me logo Genes that share ontologies with PDGFC: view
genes like me logo Genes that share phenotypes with PDGFC: view

Animal Models for PDGFC Gene

MGI Knock Outs for PDGFC:

miRNA for PDGFC Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PDGFC Gene

Localization for PDGFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFC Gene

Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDGFC Gene COMPARTMENTS Subcellular localization image for PDGFC gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10806482
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PDGFC: view

Pathways for PDGFC Gene

genes like me logo Genes that share pathways with PDGFC: view

Gene Ontology (GO) - Biological Process for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA --
GO:0007417 central nervous system development TAS 10858496
GO:0008284 positive regulation of cell proliferation --
GO:0009790 embryo development IEA --
GO:0009887 organ morphogenesis IEA --
genes like me logo Genes that share ontologies with PDGFC: view

Compounds for PDGFC Gene

(14) ApexBio Compounds for PDGFC Gene

Compound Action Cas Number
Amuvatinib (MP-470, HPK 56) Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3 [850879-09-3]
Crenolanib (CP-868596) Potent and selective PDGFR-beta inhibitor [670220-88-9]
Flumatinib mesylate multi-kinase inhibitor for c-Abl, PDGFRbeta and c-Kit [895519-91-2]
Imatinib Mesylate (STI571) Multi-target kinase inhibitor of abl, c-kit, and PDGFR [220127-57-1]
Masitinib (AB1010) tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor [790299-79-5]
MK-2461 potent inhibitor of Met, Ron, Flt1, Flt 3, PDGFRbeta, and Mer with IC50 of 2.5 nM, 7 nM, 10 nM, 22 nM, 22 nM and 24 nM, respectively. [917879-39-1]
Nintedanib (BIBF 1120) Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR [928326-83-4]
Pazopanib (GW-786034) Multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and FGFR [635702-64-6]
Ponatinib (AP24534) pan-BCR-ABL inhibitor [943319-70-8]
Regorafenib Multi-kinase inhibitor, inhibits VEGFR, PDGFR, FGFR, mutant kit, RET, and Raf-1 [755037-03-7]
SKLB610 Potent VEGFR inhibitor [1125780-41-7]
Sorafenib Multi-target kinase inhibitor of Raf kinases and tyrosine kinases [284461-73-0]
Sorafenib Tosylate Multi-target kinase inhibitor of Raf kinases and tyrosine kinases [475207-59-1]
Sunitinib malate ATP-competitive multi-target kinase inhibitor, inhibits VEGFR, PDGFR, and KIT [341031-54-7]

(4) Tocris Compounds for PDGFC Gene

Compound Action Cas Number
DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
SU 16f Potent and selective PDGFRbeta inhibitor [251356-45-3]
SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]

(1) Novoseek inferred chemical compound relationships for PDGFC Gene

Compound -log(P) Hits PubMed IDs
vegf 43.8 10
genes like me logo Genes that share compounds with PDGFC: view

Transcripts for PDGFC Gene

Unigene Clusters for PDGFC Gene

Platelet derived growth factor C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for PDGFC Gene

GeneLoc Exon Structure for
PDGFC
ECgene alternative splicing isoforms for
PDGFC

Expression for PDGFC Gene

mRNA expression in normal human tissues for PDGFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PDGFC Gene

SOURCE GeneReport for Unigene cluster for PDGFC Gene Hs.570855

mRNA Expression by UniProt/SwissProt for PDGFC Gene

Q9NRA1-PDGFC_HUMAN
Tissue specificity: Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowmans capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.
genes like me logo Genes that share expressions with PDGFC: view

No data available for mRNA differential expression in normal tissues for PDGFC Gene

Orthologs for PDGFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDGFC 35
  • 99.71 (n)
  • 99.71 (a)
PDGFC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDGFC 35
  • 86.57 (n)
  • 93.43 (a)
PDGFC 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDGFC 35
  • 94.14 (n)
  • 96.74 (a)
PDGFC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdgfc 35
  • 84.35 (n)
  • 86.96 (a)
Pdgfc 16
Pdgfc 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDGFC 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDGFC 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdgfc 35
  • 84.06 (n)
  • 85.8 (a)
chicken
(Gallus gallus)
Aves PDGFC 35
  • 79.9 (n)
  • 84.06 (a)
PDGFC 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDGFC 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfc 35
  • 73.53 (n)
  • 74.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560564 35
  • 63.44 (n)
  • 62.17 (a)
PDGFC 36
  • 62 (a)
OneToOne
Species with no ortholog for PDGFC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDGFC Gene

ENSEMBL:
Gene Tree for PDGFC (if available)
TreeFam:
Gene Tree for PDGFC (if available)

Paralogs for PDGFC Gene

Paralogs for PDGFC Gene

Selected SIMAP similar genes for PDGFC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PDGFC: view

Variants for PDGFC Gene

Sequence variations from dbSNP and Humsavar for PDGFC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs14162 -- 156,893,761(+) ACTAA(A/G)AAACT intron-variant
rs193177 -- 156,890,153(-) TTCCC(A/G)TATGA intron-variant
rs342308 -- 156,876,190(+) TATCT(A/G)TTTCT intron-variant
rs342309 -- 156,890,289(-) TTTTG(C/T)AGTGG intron-variant
rs342310 -- 156,890,086(+) GTTCA(C/T)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDGFC Gene

Variant ID Type Subtype PubMed ID
nsv830122 CNV Gain 17160897
esv2669335 CNV Deletion 23128226
esv2591391 CNV Deletion 19546169
esv2677099 CNV Deletion 23128226
esv2657401 CNV Deletion 23128226

Relevant External Links for PDGFC Gene

HapMap Linkage Disequilibrium report
PDGFC
Human Gene Mutation Database (HGMD)
PDGFC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFC Gene

Disorders for PDGFC Gene

(4) Novoseek inferred disease relationships for PDGFC Gene

Disease -log(P) Hits PubMed IDs
myocarditis chronic 68.4 2
atherosclerosis 20.2 1
tumors 9.3 15
renal disease 5.82 1

Relevant External Links for PDGFC

Genetic Association Database (GAD)
PDGFC
Human Genome Epidemiology (HuGE) Navigator
PDGFC
genes like me logo Genes that share disorders with PDGFC: view

No data available for UniProtKB/Swiss-Prot for PDGFC Gene

Publications for PDGFC Gene

  1. A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. (PMID: 10858496) Hamada T. … Miyata Y. (FEBS Lett. 2000) 2 3 4 23
  2. Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract. (PMID: 11004490) Tsai Y.J. … Chen Y.H. (Biochim. Biophys. Acta 2000) 3 4 23
  3. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. (PMID: 11313995) Zwerner J.P. … May W.A. (Oncogene 2001) 3 4 23
  4. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes. (PMID: 11342471) Uutela M. … Alitalo K. (Circulation 2001) 3 4 23
  5. PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases. (PMID: 12707385) Eitner F. … Floege J. (J. Am. Soc. Nephrol. 2003) 3 4 23

Products for PDGFC Gene

Sources for PDGFC Gene

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