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Aliases for PDGFC Gene

Aliases for PDGFC Gene

  • Platelet Derived Growth Factor C 2 3 5
  • Spinal Cord-Derived Growth Factor 3 4
  • FALLOTEIN 3 4
  • PDGF-C 3 4
  • VEGF-E 3 4
  • SCDGF 3 4
  • Secretory Growth Factor-Like Protein 3

External Ids for PDGFC Gene

Previous GeneCards Identifiers for PDGFC Gene

  • GC04M158562
  • GC04M158113
  • GC04M158260
  • GC04M158040
  • GC04M157902
  • GC04M157682
  • GC04M153433

Summaries for PDGFC Gene

Entrez Gene Summary for PDGFC Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for PDGFC Gene

PDGFC (Platelet Derived Growth Factor C) is a Protein Coding gene. Diseases associated with PDGFC include osteosclerotic myeloma and medulloblastoma. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include protein homodimerization activity and platelet-derived growth factor receptor binding. An important paralog of this gene is PDGFD.

UniProtKB/Swiss-Prot for PDGFC Gene

  • Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Tocris Summary for PDGFC Gene

  • Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.

Gene Wiki entry for PDGFC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFC Gene

Genomics for PDGFC Gene

Regulatory Elements for PDGFC Gene

Promoters for PDGFC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDGFC on UCSC Golden Path with GeneCards custom track

Genomic Location for PDGFC Gene

Chromosome:
4
Start:
156,760,454 bp from pter
End:
156,971,394 bp from pter
Size:
210,941 bases
Orientation:
Minus strand

Genomic View for PDGFC Gene

Genes around PDGFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDGFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDGFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFC Gene

Proteins for PDGFC Gene

  • Protein details for PDGFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRA1-PDGFC_HUMAN
    Recommended name:
    Platelet-derived growth factor C
    Protein Accession:
    Q9NRA1
    Secondary Accessions:
    • B4DU34
    • B9EGR8
    • Q4W5M9
    • Q9UL22

    Protein attributes for PDGFC Gene

    Size:
    345 amino acids
    Molecular mass:
    39029 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain).
    Miscellaneous:
    • A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma.

    Alternative splice isoforms for PDGFC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDGFC Gene

Proteomics data for PDGFC Gene at MOPED

Post-translational modifications for PDGFC Gene

  • N-glycosylated.
  • Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
  • Sumoylated with SUMO1.
  • Glycosylation at Asn 25 and Asn 55
  • Modification sites at PhosphoSitePlus

Other Protein References for PDGFC Gene

Antibody Products

No data available for DME Specific Peptides for PDGFC Gene

Domains & Families for PDGFC Gene

Protein Domains for PDGFC Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRA1

UniProtKB/Swiss-Prot:

PDGFC_HUMAN :
  • Contains 1 CUB domain.
  • Belongs to the PDGF/VEGF growth factor family.
Domain:
  • Contains 1 CUB domain.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with PDGFC: view

No data available for Gene Families for PDGFC Gene

Function for PDGFC Gene

Molecular function for PDGFC Gene

UniProtKB/Swiss-Prot Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
UniProtKB/Swiss-Prot Induction:
Up-regulated by EWS-FLI1 chimeric transcription factor in tumor derived cells. Up-regulated in podocytes and interstitial cells after injury/activation of these cells. FGF2 activates PDGFC transcription via EGR1. Up-regulated by TGFB1 in concert with FGF2.

LifeMap Function Summary for PDGFC Gene

Gene Ontology (GO) - Molecular Function for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10806482
genes like me logo Genes that share ontologies with PDGFC: view
genes like me logo Genes that share phenotypes with PDGFC: view

Animal Models for PDGFC Gene

MGI Knock Outs for PDGFC:

Animal Model Products

miRNA for PDGFC Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDGFC Gene

Localization for PDGFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFC Gene

Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane. Note=Sumoylated form is predominant in the nucleus (PubMed:15247255). Stored in alpha granules in platelets (PubMed:15061151). {ECO:0000269 PubMed:16443219}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDGFC Gene COMPARTMENTS Subcellular localization image for PDGFC gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 4
golgi apparatus 4
nucleus 3

Gene Ontology (GO) - Cellular Components for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PDGFC: view

Pathways & Interactions for PDGFC Gene

genes like me logo Genes that share pathways with PDGFC: view

Gene Ontology (GO) - Biological Process for PDGFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA --
GO:0007417 central nervous system development TAS 10858496
GO:0007596 blood coagulation IBA --
GO:0009887 organ morphogenesis IEA --
GO:0031954 positive regulation of protein autophosphorylation IBA --
genes like me logo Genes that share ontologies with PDGFC: view

No data available for SIGNOR curated interactions for PDGFC Gene

Drugs & Compounds for PDGFC Gene

(1) Drugs for PDGFC Gene - From: DGIdb and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 486

(5) Additional Compounds for PDGFC Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AG 18
118409-57-7
DMPQ dihydrochloride
1123491-15-5
SU 16f
251356-45-3
SU 6668
252916-29-3

(5) Tocris Compounds for PDGFC Gene

Compound Action Cas Number
AG 18 EGFR/PDGFR-kinase inhibitor 118409-57-7
DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta 1123491-15-5
SU 16f Potent and selective PDGFRbeta inhibitor 251356-45-3
SU 6668 PDGFR, VEGFR and FGFR inhibitor 252916-29-3
Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor 341031-54-7
genes like me logo Genes that share compounds with PDGFC: view

Transcripts for PDGFC Gene

Unigene Clusters for PDGFC Gene

Platelet derived growth factor C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for PDGFC Gene

GeneLoc Exon Structure for
PDGFC
ECgene alternative splicing isoforms for
PDGFC

Expression for PDGFC Gene

mRNA expression in normal human tissues for PDGFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDGFC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.9) and Amniocyte (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFC Gene



SOURCE GeneReport for Unigene cluster for PDGFC Gene Hs.570855

mRNA Expression by UniProt/SwissProt for PDGFC Gene

Q9NRA1-PDGFC_HUMAN
Tissue specificity: Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowmans capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with PDGFC: view

Protein tissue co-expression partners for PDGFC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PDGFC Gene

Orthologs for PDGFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDGFC 35
  • 86.57 (n)
  • 93.43 (a)
PDGFC 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDGFC 35
  • 94.14 (n)
  • 96.74 (a)
PDGFC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdgfc 35
  • 84.35 (n)
  • 86.96 (a)
Pdgfc 16
Pdgfc 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDGFC 35
  • 99.71 (n)
  • 99.71 (a)
PDGFC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdgfc 35
  • 84.06 (n)
  • 85.8 (a)
oppossum
(Monodelphis domestica)
Mammalia PDGFC 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDGFC 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDGFC 35
  • 79.9 (n)
  • 84.06 (a)
PDGFC 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDGFC 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfc 35
  • 73.53 (n)
  • 74.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560564 35
  • 63.44 (n)
  • 62.17 (a)
PDGFC 36
  • 62 (a)
OneToOne
Species with no ortholog for PDGFC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDGFC Gene

ENSEMBL:
Gene Tree for PDGFC (if available)
TreeFam:
Gene Tree for PDGFC (if available)

Paralogs for PDGFC Gene

Paralogs for PDGFC Gene

(1) SIMAP similar genes for PDGFC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PDGFC: view

Variants for PDGFC Gene

Sequence variations from dbSNP and Humsavar for PDGFC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs14162 -- 156,893,761(+) ACTAA(A/G)AAACT intron-variant
rs342308 -- 156,876,190(+) TATCT(A/G)TTTCT intron-variant
rs342309 -- 156,890,289(-) TTTTG(C/T)AGTGG intron-variant
rs342310 -- 156,890,086(+) GTTCA(C/T)GAGGT intron-variant
rs342311 -- 156,889,261(-) ACCTG(C/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDGFC Gene

Variant ID Type Subtype PubMed ID
nsv830122 CNV Gain 17160897
esv2669335 CNV Deletion 23128226
esv2591391 CNV Deletion 19546169
esv2677099 CNV Deletion 23128226
esv2657401 CNV Deletion 23128226

Variation tolerance for PDGFC Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDGFC Gene

HapMap Linkage Disequilibrium report
PDGFC
Human Gene Mutation Database (HGMD)
PDGFC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFC Gene

Disorders for PDGFC Gene

MalaCards: The human disease database

(2) MalaCards diseases for PDGFC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
osteosclerotic myeloma
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards
Search PDGFC in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDGFC

Genetic Association Database (GAD)
PDGFC
Human Genome Epidemiology (HuGE) Navigator
PDGFC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDGFC
genes like me logo Genes that share disorders with PDGFC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFC Gene

Publications for PDGFC Gene

  1. A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. (PMID: 10858496) Hamada T. … Miyata Y. (FEBS Lett. 2000) 2 3 4 23 67
  2. Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma. (PMID: 19569180) Yamano Y. … Tanzawa H. (Int. J. Cancer 2010) 3 23
  3. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. (PMID: 18573494) WAYgsAoter D. … Eriksson P. (Atherosclerosis 2009) 3 23
  4. The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P. (PMID: 19092777) Choi S.J. … Hart T.C. (Eur. J. Hum. Genet. 2009) 3 23
  5. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. (PMID: 19111878) Crawford Y. … Ferrara N. (Cancer Cell 2009) 3 23

Products for PDGFC Gene

Sources for PDGFC Gene

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