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PDGFB Gene

protein-coding GIFtS: 69

GC22M037944

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SIS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Becaplermin ^³
FLJ12858 ^²
PDGF-2 ^³
PDGF2 ^², ³
SIS ^², ³, ⁵
SSV ^¹, ²
becaplermin ^²
c-sis ^², ³

Descriptions
PDGF subunit B ^³
PDGF, B chain ^²
Platelet-derived growth factor B chain ^³
Platelet-derived growth factor beta polypeptide ^³
Platelet-derived growth factor, beta polypeptide (oncogene SIS) ^²
platelet-derived growth factor 2 ^²
platelet-derived growth factor beta ^²
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) ^²
platelet-derived growth factor, B chain ^²

External Ids
HGNC: 8800¹
Entrez Gene: 5155²
UniProtKB: P01127³
Ensembl: ENSG00000100311⁷

Search outside databases for aliases for PDGFB gene

Previous GC identifers: GC22M036234 GC22M037862

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PDGFB:

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four

members of this family are mitogenic factors for cells of mesenchymal origin and are characterized

by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a

heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers

are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for

COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma

protuberans resulting from unregulated expression of growth factor. Two alternatively spliced

transcript variants encoding different isoforms have been identified for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Function: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin.

Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It

is released by platelets upon wounding and plays an important role in stimulating adjacent cells

to grow and thereby heals the wound

Gene Wiki entry for PDGFB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDGFB gene

Entrez Gene cytogenetic band: 22q12.3-q13.1|22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

PDGFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M037944: (about GC identifiers)

Start:	37,949,665 bp from pter
End:	37,970,936 bp from pter
Size:	21,272 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127 (See protein sequence)

Recommended Name: Platelet-derived growth factor subunit B precursor

Size: 241 amino acids; 27283 Da

Subunit: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and

B chains are implicated in transformation processes. Interacts with XLKD1 (By similarity)

Subcellular location: Secreted

Miscellaneous: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor

PDB structures from and Proteopedia :

1PDG (3D)

Secondary accessions: P78431 Q9UF23

REFSEQ proteins (2 alternative transcripts):

NP_002599.1 NP_148937.1

ENSEMBL proteins:

ENSP00000370963 ENSP00000379966 ENSP00000330382

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PDGFB
	Millipore Purified and/or Recombinant PDGFB Protein
	Sigma-Aldrich Proteins for PDGFB
	R&D Systems Recombinant & Natural Proteins for PDGFB (PDGF-BB)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PDGF BB, PDGF AB + BB, PDGFAA + PDGFBB, PDGF AB)
	Human Recombinant Proteins from Abnova (PDGFB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	1661670
GO:0005737	cytoplasm	IEA	--
GO:0009986	cell surface	IDA	291037 2836953 9685360
GO:0016020	membrane	IEA	--
GO:0031089	platelet dense granule lumen	EXP	287022

About this table

Antibodies for PDGFB:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PDGFB
	Sigma-Aldrich Antibodies for PDGFB
	R&D Systems Antibodies for PDGFB (PDGF-B, PDGF-BB)
	Antibodies from Abcam (PDGF BB, PDGF AB + BB, PDGFAA + PDGFBB, PDGF AB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDGFB)
	Novus Biologicals Antibodies for PDGFB

Assays for PDGFB:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of PDGFB
	R&D Systems ELISAs for PDGFB (PDGF-BB) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01127

ProtoNet protein and cluster: P01127

3 Blocks protein families:

IPB000072 Platelet-derived growth factor (PDGF)

IPB002400 Growth factor cystine knot superfamily signature

IPB006782 Platelet-derived growth factor

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Similarity: Belongs to the PDGF/VEGF growth factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDGFB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDGFB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033016

Applied Biosystems Silencer® siRNAs for PDGFB

Sigma-Aldrich siRNA and siRNA Panels for PDGFB

Sigma-Aldrich shRNA for PDGFB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PDGFB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002608
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002608
untagged cDNA clones in CMV expression vector (see all 3): NM_002608

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002608

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Function: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin.

Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It

is released by platelets upon wounding and plays an important role in stimulating adjacent cells

to grow and thereby heals the wound

Genatlas biochemistry entry for PDGFB:

platelet-derived growth factor,beta polypeptide,27.3kDa,(simian sarcoma viral (v-sis) oncogene

homolog),potent mitogen for cells of mesenchymal origin,also involved in transformation process

15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Pdgfb) (see all 17 ):

	embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	liver/biliary system	muscle	nervous system
no phenotypic analysis	pigmentation	renal/urinary system	reproductive system	respiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005161	platelet-derived growth factor receptor binding	NAS	1661670
GO:0005518	collagen binding	IDA	8900172
GO:0008083	growth factor activity	IEA	--
GO:0042803	protein homodimerization activity	IDA	2836953
GO:0043498	cell surface binding	IDA	291037 2538439 2836953

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for PDGFB (Your Favorite Gene powered by Ingenuity) (see all 11 )

Human Embryonic Stem Cell Pluripotency
Glioma Signaling
Renal Cell Carcinoma Signaling
Clathrin-mediated Endocytosis
Actin Cytoskeleton Signaling

GeneDecks PDGFB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PDGFB

5/128 Interacting proteins for PDGFB (P01127¹ ENSP00000330382³) via UniProtKB, MINT, and/or STRING (see all 128 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDGFRB	P09619¹, ENSP00000261799³	EBI-1554925, EBI-641237 STRING (score=.999)
EGF	ENSP00000265171³	STRING (score=.996)
THBS1	ENSP00000260356³	STRING (score=.988)
LRP1	ENSP00000243077³	STRING (score=.983)
IGF1R	ENSP00000268035³	STRING (score=.978)

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5/19 Gene Ontology (GO) biological process terms (links to tree view) (see all 19 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0006929	substrate-bound cell migration	IEA	--
GO:0007179	transforming growth factor beta receptor signaling pathway	IEA	--
GO:0009611	response to wounding	NAS	1661670

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PDGFB

Browse Small Molecules at Sigma-Aldrich

Compounds for PDGFB available from Tocris Bioscience

Compound	Action	CAS number
AG 213	EGFR/PDGFR-kinase inhibitor	[122520-86-9]
DMPQ dihydrochloride	Potent, selective inhibitor of beta-type PDGFR	[137206-97-4]
AG 18	EGFR/PDGFR-kinase inhibitor	[118409-57-7]

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UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Pharmaceutical: Available under the name Regranex (Ortho-McNeil). Used to promote healing in

diabetic neuropathic foot ulcers

10/17 Novoseek chemical compound relationships for PDGFB gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	34.79	7	10652433 (1), 12651221 (1), 7862136 (1), 1646396 (1) (see all 5)
tgf beta1	32.18	6	15682418 (3), 15201664 (2), 16308570 (1)
cystine	29.44	2	9027341 (1), 15192308 (1)
ribonucleic acid	27.13	5	8177392 (2), 1651380 (1), 8520779 (1), 11063355 (1)
thymidine	26.88	2	16014047 (1), 10437122 (1)
oligonucleotide	9.69	1	8177392 (1)
phosphotyrosine	8.07	1	11869525 (1)
procollagen	6.80	1	7806036 (1)
pd 98,059	3.40	2	15339908 (1), 10753966 (1)
glucose	1.38	2	11811779 (1), 12349953 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDGFB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDGFB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033016

Sigma-Aldrich siRNA and siRNA Panels for PDGFB

Sigma-Aldrich shRNA for PDGFB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002608 NM_033016

REFSEQ mRNAs for PDGFB gene (2 alternative transcripts):

NM_002608.2 NM_033016.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002608 NM_033016

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002608
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002608
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002608

Additional cDNA sequence:

AK022920.1 BC029822.1 BC077725.1 CR456538.1 CR541807.1 CR601724.1 CR620580.1 M12783.1

M32009.1 X02744.1 X02811.1 X03702.1 X83705.1

3 DOTS entries:

DT.414662 DT.100755186 DT.100834861

24/112 AceView cDNA sequences (see all 112 ):

CR541807 CR601724 BC077725 CR620580 AA947584 CR456538 CD367557 AI304555

CD634603 H55385 BX418772 M32009 BX280801 BX952119 X83705 BX377589

AI635801 BC029822 BQ367608 AI346510 CD634604 W72000 X02744 AI683393

highest scoring ESTs for PDGFB:

M12783 AL535130 BC029822 BE146037 BE146119 BE146179 BE146344 BF757851 BG387377 BI824698

Unigene Cluster for PDGFB:

Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

Hs.1976 [show with all ESTs]

Unigene Representative Sequence: M12783

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000381551 ENST00000396740 ENST00000331163

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PDGFB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDGFB

¹ / ² / ³

7 probe-sets matching PDGFB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1573_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M12783	1.00	1.00	1.00	1
204200_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002608	0.60	1.00	0.82	1
216061_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU150748	0.60	1.00	0.82	1
217112_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204200_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216061_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217112_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PDGFB for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCTCCATTT

SOURCE GeneReport for Unigene cluster: Hs.1976
Expression variation in blood from EXPOLDB for PDGFB
UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127
Tissue specificity: Expressed at high levels in the heart, brain (sustantia nigra), placenta and
fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and
lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDGFB gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDGFB¹	--	platelet-derived growth factor beta polypeptide (simian more	91.42(n) 93.36(a)	442986 NM_001003383.1 NP_001003383.1
chimpanzee (Pan troglodytes)	PDGFB¹	--	platelet-derived growth factor beta polypeptide (simian more	99.45(n) 99.59(a)	458844 XM_515140.2 XP_515140.2
cow (Bos taurus)	PDGFB¹	--	platelet-derived growth factor beta polypeptide (simian more	87.72(n) 90.91(a)	540106 NM_001017953.1 NP_001017953.1
rat (Rattus norvegicus)	Pdgfb¹	--	platelet-derived growth factor beta polypeptide (simian more	85.48(n) 87.97(a)	24628 XM_343293.3 XP_343294.3
mouse (Mus musculus)	Pdgfb^{1, 5}	15 (46.80 cM)⁵	platelet derived growth factor, B polypeptide^{1, 5}	86.31(n)¹ 89.63(a)¹	18591¹ NM_011057.3¹ NP_035187.2¹ AC113595⁵ AF162784⁵ (see all 23)

About this table Species with no ortholog for PDGFB

ENSEMBL Gene Tree for PDGFB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PDGFB gene

PDGFA² LOC729619²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/179 NCBI SNPs in PDGFB are shown (see all 179 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 87)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs130653^1,2	A,C,F,H,O	37972686(-)	`GAAGGA/TTCCAG`	1	--	ng3¹		9		MN EU EA WA NA	964
	rs130654^1,2	A,C,F,H	37972600(-)	`AGGAGG/CAGGGT`	1	--	ng3¹		8		EU EA WA	838
--	rs1800818^1,2	A,C,F	37970649(-)	`CGAGCG/AGGCGG`	1	--	ut5¹ ese³		1		MN	184
--	rs7289325^1,2	A,C	37972523(+)	`ggcttA/Ttgggt`	1	--	ng3¹		0	--	--	--	--
	rs5757577^1,2	A,C	37972640(+)	`TCCATA/GTGGAG`	1	--	ng3¹		0	--	--	--	--
	rs9611112^1,2	F,H	37949948(+)	`TGCAAG/ACAGGG`	2	--	ut3¹ ese³		4		EU EA WA	414
	rs13306692^1,2	H	37950277(-)	`gtatgC/Taggga`	2	--	ut3¹ ese³		4		EU EA WA	418
--	rs35677215^1,2	F	37951655(-)	`AGAGTTG/-GTGTG`	2	--	ut3¹		5		MN CSAM EA	408
--	rs17565^1,2	F	37957767(-)	`TGACCA/GTTGCT`	2	I/V	mis¹ ese³		7		MN CSAM EA NA	520
	rs8141658^1,2	H	37967768(+)	`TCAGAC/GTCACA`	2	--	int¹ ng3¹		4		EU EA WA	414

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HapMap Linkage Disequilibrium images for PDGFB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 190040

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

A chromosomal aberration involving PDGFB is a cause of dermatofibrosarcoma protuberans

(DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with COLA1. DFSP is an uncommon, locally

aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It

typically occurs during early or middle adult life and is most frequently located on the trunk and

proximal extremities

10/84 Novoseek disease relationships for PDGFB gene (see all 84 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dermatofibrosarcoma protuberans	83.46	10	17431412 (2), 15681532 (1), 12786837 (1), 14643521 (1) (see all 8)
dermatofibrosarcoma	61.81	2	9739023 (1), 15583853 (1)
diabetic foot	58.15	10	11548912 (3), 14652415 (1), 16785777 (1), 11849120 (1) (see all 8)
foot ulcer	55.95	4	18686746 (2), 14652415 (1), 10719543 (1)
ulcer	52.51	37	16464208 (4), 9589248 (4), 11075012 (3), 10564562 (3) (see all 16)
glioma	50.63	37	8177392 (6), 1508312 (5), 12651601 (5), 17292826 (3) (see all 13)
gingival overgrowth	46.64	10	9029455 (2), 8708960 (2), 8708959 (1), 8463938 (1)
glioblastoma	44.96	6	2117995 (1), 1324785 (1), 8789659 (1), 7757303 (1) (see all 5)
renal fibrosis	44.59	2	18077793 (1), 14514732 (1)
tumors	43.85	76	7903911 (4), 18758297 (4), 1353485 (3), 2164040 (3) (see all 49)

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Human Gene Mutation Database: PDGFB
Genetic Association Database: PDGFB
Human Genome Epidemiology Navigator: PDGFB (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Team Identifies New Oncogene for Brain Tumors

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/486 PubMed articles for PDGFB gene (see all 486 ):

Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation. (PubMed id 1661670)^{2, 3, 4} Clements J.M....Green D.R. (1991)
Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor. (PubMed id 2991848)^{2, 3, 4} Ratner L.... Wong-Staal F. (1985)
PDGF D, a novel protease-activated growth factor. (PubMed id 11331882)^{1, 3, 4} LaRochelle W.J.... Lichenstein H.S. (2001)
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. (PubMed id 8988177)^{1, 3, 4} Simon M.-P.... Dumanski J.P. (1997)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Dermatofibrosarcoma protuberans of breast. (PubMed id 12660034)^{3, 4} Sandberg A.A.... Hashimoto H. (2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{3, 4} Dunham I....O'Brien K.P. (1999)
Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (PubMed id 1317862)^{3, 4} Andersson M.... Heldin C.-H. (1992)
Crystal structure of human platelet-derived growth factor BB. (PubMed id 1396586)^{3, 4} Oefner C.... Hosang M. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5155	HGNC: 8800	AceView: PDGFB	Ensembl:ENSG00000100311	euGenes: HUgn5155
ECgene: PDGFB	H-InvDB: PDGFB

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PDGFB	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: PDGF	http://www.rndsystems.com/molecule_detail.aspx?m=1967
Regranex	http://www.regranex.com/

Licensable Technologies for PDGFB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PDGFB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDGFB-related products

	Millipore Custom Antibody & Bulk Services
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GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PDGFB Gene at Home site.
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PDGFB Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for PDGFB

Summaries
for PDGFB

Genomic Location
for PDGFB

Proteins
for PDGFB

Protein Domains/
Families
for PDGFB

Gene Function
for PDGFB

Pathways & Interactions
for PDGFB

Drugs & Compounds
for PDGFB

Transcripts
for PDGFB

Expression
for PDGFB

Orthologs
for PDGFB

Paralogs
for PDGFB

SNPs/Variants
for PDGFB

Disorders & Mutations
for PDGFB

Medical News
for PDGFB

Publications
for PDGFB

Search for PDGFB

Genome Databases showing PDGFB

Other Databases showing PDGFB

Specialized Databases showing PDGFB

Licensable Technologies
for PDGFB

Services
for PDGFB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDGFB Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor PDGFB

Summariesfor PDGFB

Genomic Locationfor PDGFB

Proteinsfor PDGFB

Protein Domains/Familiesfor PDGFB

Gene Functionfor PDGFB

Pathways & Interactionsfor PDGFB

Drugs & Compoundsfor PDGFB

Transcriptsfor PDGFB

Expression for PDGFB

Orthologsfor PDGFB

Paralogsfor PDGFB

SNPs/Variantsfor PDGFB

Disorders & Mutationsfor PDGFB

Medical Newsfor PDGFB

Publicationsfor PDGFB

Search for PDGFB

Genome Databases showing PDGFB

Other Databases showing PDGFB

Specialized Databases showing PDGFB

Licensable Technologiesfor PDGFB

Servicesfor PDGFB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDGFB

Summaries
for PDGFB

Genomic Location
for PDGFB

Proteins
for PDGFB

Protein Domains/
Families
for PDGFB

Gene Function
for PDGFB

Pathways & Interactions
for PDGFB

Drugs & Compounds
for PDGFB

Transcripts
for PDGFB

Expression
for PDGFB

Orthologs
for PDGFB

Paralogs
for PDGFB

SNPs/Variants
for PDGFB

Disorders & Mutations
for PDGFB

Medical News
for PDGFB

Publications
for PDGFB

Licensable Technologies
for PDGFB

Services
for PDGFB