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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDGFB Gene

protein-coding GIFtS: 70
GCID: GC22M039619

platelet-derived growth factor beta polypeptide

(Previous name: platelet-derived growth factor beta polypeptide (simian...)
(Previous symbol: SIS)

Explore 126 diseases affiliated with
PDGFB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Platelet-Derived Growth Factor Beta Polypeptide¹ ² ³		PDGF Subunit B² ³
SIS¹ ² ³ ⁵		Becaplermin³
SSV¹ ²		C-Sis¹
Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog)¹ ²		PDGF, B Chain²
Platelet-Derived Growth Factor B Chain² ³		Platelet-Derived Growth Factor 2²
Proto-Oncogene C-Sis² ³		Platelet-Derived Growth Factor Subunit B²
PDGF-2² ³		Platelet-Derived Growth Factor, Beta Polypeptide (Oncogene SIS)²
PDGF2² ³		Becaplermin³

External Ids:	HGNC: 8800¹	Entrez Gene: 5155²	Ensembl: ENSG00000100311⁷	OMIM: 190040⁵	UniProtKB: P01127³

Export aliases for PDGFB gene to outside databases

Previous GC identifers: GC22M036234 GC22M037862 GC22M037944 GC22M022587

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDGFB:

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this

family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This

gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor

alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated

with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for

collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma

protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants

encoding different isoforms have been identified for this gene. (provided by RefSeq, Feb 2013)

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation,

cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal

proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung,

heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli.

Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By

similarity)

summary for PDGFB:

Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine

kinase activity. They have roles in the regulation of many biological processes including embryonic

development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of

some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,

which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce

receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates

the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma

pathways.

Gene Wiki entry for PDGFB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDGFB gene promoter:
SRF NF-1 SRF (504 AA)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PDGFB promoter sequence

Search SABiosciences Chromatin IP Primers for PDGFB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

PDGFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M039619: view genomic region (about GC identifiers)

Start:	39,619,364 bp from pter	End:	39,640,957 bp from pter
Size:	21,594 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127 (See protein sequence)

Recommended Name: Platelet-derived growth factor subunit B precursor

Size: 241 amino acids; 27283 Da

Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer.

The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.

The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA

and PDGFRB. Interacts with XLKD1 (By similarity)

Subcellular location: Secreted. Note=Released by platelets upon wounding

4 PDB 3D structures from and Proteopedia for PDGFB:

1PDG (3D)

3MJG (3D)

4HQU (3D)

4HQX (3D)

Secondary accessions: G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23

Alternative promoter usage: 2 isoforms: P01127-1 P01127-2

Explore the universe of human proteins at neXtProt for PDGFB: NX_P01127

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01127

PDGFB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002599.1 NP_148937.1

ENSEMBL proteins:

ENSP00000330382 ENSP00000370963 ENSP00000402306 ENSP00000405780

Reactome Protein details: P01127
Human Recombinant Protein Products for PDGFB:

	EMD Millipore Purified and/or Recombinant PDGFB Protein
	R&D Systems Recombinant & Natural Proteins for PDGFB (PDGF-BB)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): PDGFB OriGene Custom Protein Services for PDGFB
	GenScript Purified and Recombinant Proteins for PDGFB
	Novus Biologicals PDGFB Proteins Novus Biologicals PDGFB Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PDGFB
	Uscn Proteins for PDGFB

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005576	extracellular region	TAS	--
GO:0005737	cytoplasm	ISS	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0009986	cell surface	IDA	2836953

PDGFB for ontologies About GeneDecksing

PDGFB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFB
	R&D Systems Antibodies for PDGFB (PDGF-B, PDGF-BB)
	Browse OriGene Antibodies OriGene Custom Antibody Services for PDGFB
	GenScript Custom Superior Antibodies Services for PDGFB
	Novus Biologicals PDGFB Antibodies
	Abcam antibodies for PDGFB
	Uscn Antibodies for PDGFB
	ThermoFisher Antibodies for PDGFB

Assay Products for PDGFB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for PDGFB (PDGF-BB) (see all)
	GenScript Custom Assay Services for PDGFB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PDGFB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDGFB for domains About GeneDecksing

3 InterPro domains/families:

IPR023581 PD_growth_factor_CS

IPR000072 PD_growth_factor

IPR006782 PDGF_N

Graphical View of Domain Structure for InterPro Entry P01127

ProtoNet protein and cluster: P01127

3 Blocks protein families:

IPB000072 Platelet-derived growth factor (PDGF)

IPB002400 Growth factor cystine knot superfamily signature

IPB006782 Platelet-derived growth factor

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Similarity: Belongs to the PDGF/VEGF growth factor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PDGFB_HUMAN, P01127

Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation,

cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal

proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung,

heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli.

Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By

platelet-derived growth factor,beta polypeptide,27.3kDa,(simian sarcoma viral (v-sis) oncogene homolog),potent mitogen

for cells of mesenchymal origin,also involved in transformation process

Summary:

During embryonic development, PDGFB as signaling molecule is secreted from the following cells: Angioblasts in Embryonic Capillary Plexus, Endothelial Cells in Blood Brain Barrier (see all 4).

It affects the following cells: Kidney Endothelial Cells in S-shaped Body, Mesangial Cells in Glomerulus (see all 7).

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005161	platelet-derived growth factor receptor binding	NAS	1661670
GO:0005515	protein binding	IPI	2536956
GO:0005518	collagen binding	IDA	8900172
GO:0008083	growth factor activity	IEA	--
GO:0016176	superoxide-generating NADPH oxidase activator activity	IDA	17942966

PDGFB for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PDGFB:

Decreased substrate adherent c

Increased cell death HMECs cel

15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Pdgfb) (see all 17):

cardiovascular system	embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle
nervous system	no phenotypic analysis	pigmentation	renal/urinary system	reproductive system

PDGFB for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PDGFB: Pdgfb^tm3Cbet Pdgfb^tm3.1Cbet Pdgfb^tm1Cbet

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PDGFB

miRNA Products:		miRTarBase miRNAs that target PDGFB: hsa-mir-146b-3p (MIRT005548)

		OriGene 3'-UTR Clone (see all 2): PDGFB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFB
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFB (see all 38):
		hsa-miR-579 hsa-miR-2052 hsa-miR-19b-2* hsa-let-7d hsa-miR-1224-3p hsa-miR-29a hsa-let-7g hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: PDGFB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFB (see all 7) OriGene shRNA RFP: PDGFB OriGene siRNA: PDGFB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFB
		Sirion Biotech Custom design and validation of potent shRNA sequences against PDGFB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PDGFB
			Sirion Biotech Customized adenovirus for overexpression of PDGFB Sirion Biotech Customized adenovirus for potent knockdown of PDGFB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFB (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PDGFB (NM_002608)
		Sino Biological Human cDNA Clone for PDGFB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PDGFB
		LifeMap BioReagents: cell line associated with PDGFB: PureStem ES-209, Meso-prx/latp Progenitor
		Sirion Biotech Customized stable knockdown cell line services for PDGFB Sirion Biotech Customized inducible knockdown cell line services for PDGFB Sirion Biotech Customized stable overexpressing cell line services for PDGFB Sirion Biotech Customized inducible overexpressing cell line services for PDGFB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/42 super-pathways (see all 42) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for PDGFB

	Development PDGF signaling via MAPK cascades
	Development PDGF signaling via STATs and NF-kB
	Cytoskeleton remodeling Role of PDGFs in cell migration
	G-protein signaling H-RAS regulation pathway

5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDGFB (see all 59)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

5 GeneGo (Thomson Reuters) Pathways for PDGFB

	G-protein signaling H-RAS regulation pathway
	Development PDGF signaling via STATs and NF-kB
	Cytoskeleton remodeling Role of PDGFs in cell migration
	Development PDGF signaling via MAPK cascades
	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

5/7 BioSystems Pathways for PDGFB (see all 7)

	MAPK signaling pathway
	Angiogenesis
	Focal Adhesion
	Regulation of Actin Cytoskeleton
	PDGFR-beta signaling pathway

5/35 Reactome Pathways for PDGFB (see all 35)

	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction
	Signaling by PDGF
	Downstream Signaling Events Of B Cell Receptor (BCR)

5/10 Kegg Pathways (Kegg details for PDGFB) (see all 10):

	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	Focal adhesion
	Gap junction
	Regulation of actin cytoskeleton

PDGFB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PDGFB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/76 Interacting proteins for PDGFB (P01127³ ENSP00000330382⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPG2	P98160³, ENSP00000363827⁴	I2D: score=2 STRING: ENSP00000363827
LRP1	Q07954³, ENSP00000243077⁴	I2D: score=2 STRING: ENSP00000243077
PDGFRB	P09619³, ENSP00000261799⁴	I2D: score=2 STRING: ENSP00000261799
SPARC	P09486³, ENSP00000231061⁴	I2D: score=2 STRING: ENSP00000231061
ART1	P52961³, ENSP00000250693⁴	I2D: score=1 STRING: ENSP00000250693

About this table

Gene Ontology (GO): 5/77 biological process terms (GO ID links to tree view) (see all 77): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	--	--
GO:0001666	response to hypoxia	IEA	--
GO:0001892	embryonic placenta development	ISS	--
GO:0001938	positive regulation of endothelial cell proliferation	IDA	9685360
GO:0002548	monocyte chemotaxis	IDA	17991872

PDGFB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PDGFB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for PDGFB

Compounds for PDGFB available from Tocris Bioscience About this table

Compound	Action	CAS #
DMPQ dihydrochloride	Potent, selective inhibitor of PDGFRbeta	[137206-97-4]
AG 18	EGFR/PDGFR-kinase inhibitor	[118409-57-7]

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Pharmaceutical: Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot

ulcers

10/34 Novoseek chemical compound relationships for PDGFB gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
regranex	89.4	8	16464208 (2), 16676854 (1), 10417749 (1), 19067861 (1) (see all 7)
imatinib	59.6	5	20042679 (1), 19234339 (1), 17145809 (1), 19106991 (1) (see all 5)
vegf	55.5	39	17671690 (3), 12651601 (3), 18506785 (2), 16596190 (2) (see all 29)
tgf beta1	36.4	7	15682418 (3), 15201664 (2), 16308570 (1), 19706334 (1)
tyrosine	34.5	7	10652433 (1), 12651221 (1), 7862136 (1), 1646396 (1) (see all 5)
cystine	27.3	2	9027341 (1), 15192308 (1)
ribonucleic acid	25.5	5	8177392 (2), 1651380 (1), 8520779 (1), 11063355 (1)
thymidine	25.3	2	16014047 (1), 10437122 (1)
polyglycolic acid	18.4	4	11352431 (2), 10597824 (1)
bromodeoxyuridine	12.6	1	10024303 (1)

Search CenterWatch for drugs/clinical trials and news about PDGFB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDGFB gene (2 alternative transcripts):

NM_002608.2 NM_033016.2

Unigene Cluster for PDGFB:

Platelet-derived growth factor beta polypeptide

Hs.1976 [show with all ESTs]

Unigene Representative Sequence: M12783

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331163(uc003axe.3 uc003axf.3) ENST00000381551 ENST00000455790

ENST00000440375

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PDGFB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFB
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFB (see all 38):
		hsa-miR-579 hsa-miR-2052 hsa-miR-19b-2* hsa-let-7d hsa-miR-1224-3p hsa-miR-29a hsa-let-7g hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: PDGFB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFB (see all 7) OriGene shRNA RFP: PDGFB OriGene siRNA: PDGFB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFB
		Sirion Biotech Custom design and validation of potent shRNA sequences against PDGFB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFB (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PDGFB (NM_002608)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDGFB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PDGFB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDGFB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFB

Additional cDNA sequence:

AK022920.1 BC029822.1 BC077725.1 CR456538.1 CR541807.1 M12783.1 M32009.1 X02744.1

X02811.1 X03702.1 X83705.1

3 DOTS entries:

DT.414662 DT.100755186 DT.100834861

24/112 AceView cDNA sequences (see all 112):

BC029822 CR601724 AI635801 M32009 BX418772 CR620580 CD634603 BX280801

BX377589 AA947584 H55385 BC077725 BX952119 X83705 AI304555 CR541807

CR456538 CD367557 BX366754 CB960288 NM_033016 X02811 T29371 BG253114

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDGFB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCCATTT

About this image

PDGFB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pericytes

Blood Brain Barrier, Endothelium

Endothelium

Arteries

Endothelial tip cells

Endothelium

Kidney

Kidney Endothelial Cells

Endothelium

Lateral Plate Mesoderm

Embryonic Capillary Plexus

Angioblasts

Endothelium

Neural Tube

Perineural capillary Plexus

Angioblasts

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

See PDGFB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDGFB

SOURCE GeneReport for Unigene cluster: Hs.1976

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Tissue specificity: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney.

Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including PDGFB (see all 9):

Fibrosis in human mouse rat

NFKB Signaling Targets in human mouse rat

Angiogenic Growth Factors in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Angiogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDGFB Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PDGFB gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pdgfb^{1 , 5}	platelet derived growth factor, B polypeptide^{1, 5}	86.31(n)¹ 89.63(a)¹		15 (37.85 cM)⁵ 18591¹ NM_011057.3¹ NP_035187.2¹ 79995900⁵
chicken (Gallus gallus)	Aves	PDGFB¹	platelet-derived growth factor beta polypeptide	66.82(n) 59.91(a)		374128 NM_204270.2 NP_989601.2
lizard (Anolis carolinensis)	Reptilia	PDGFB⁶	--	53(a)	1 ↔ 1	5(24508874-24525057)
zebrafish (Danio rerio)	Actinopterygii	LOC796490¹	uncharacterized LOC796490	48.97(n) 41.75(a)		796490 XM_001336795.4 XP_001336831.3

ENSEMBL Gene Tree for PDGFB (if available)
TreeFam Gene Tree for PDGFB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PDGFB gene

PDGFA²

1 SIMAP similar gene for PDGFB using alignment to 4 protein entries: PDGFB_HUMAN (see all proteins):

PDGFA

PDGFB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75538583^1,2	C,F	--	22586260(+)	`AGACCC/TGGCTT`	2	--	int¹		1		WA	118
rs56031201^1,2	C	--	22586848(+)	`AGGAAC/GCAGGT`	2	--	ut3¹		0	--	--	--	--
rs80174093^1,2	C	--	22586923(+)	`CCAGGG/AGGTCT`	2	--	ut3¹		2		CSA WA	120
rs9611110^1,2	C	--	22586931(+)	`TCTTGA/C/GGGATC`	4	--	ut3¹ ese³		1		CSA	1
rs9611112^1,2	C,F,H	--	22587036(+)	`TGCAAG/ACAGGG`	2	--	ut3¹ ese³		5		NS EA NA	534
rs13306693^1,2	C,F,H	--	22587209(-)	`TTGGAG/ATGGCC`	2	--	ut3¹		7		NS EA NA	668
rs55680074^1,2	C	--	22587213(+)	`ACTCC-/AAGCCA`	2	--	ut3¹		0	--	--	--	--
rs115948772^1,2	C,F	--	22587299(+)	`CCTACA/CTCTGC`	2	--	ut3¹		1		WA	118
rs56133813^1,2	C	--	22587675(+)	`CACCAC/TCTACA`	2	--	ut3¹		0	--	--	--	--
rs56380606^1,2	C	--	22587681(+)	`CTACA-/GCCACC`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PDGFB (39619364 - 39640957 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDGFB: --
Human Gene Mutation Database (HGMD): PDGFB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDGFB

DNA2.0 Custom Variant and Variant Library Synthesis for PDGFB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PDGFB for disorders About GeneDecksing

OMIM gene information: 190040 OMIM disorders: --

UniProtKB/Swiss-Prot: PDGFB_HUMAN, P01127

Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation

t(17;22)(q22;q13) with PDGFB

20/126 diseases for PDGFB (see all 126): About MalaCards

dermatofibrosarcoma protuberans dermatofibrosarcoma meningioma, sis-related meningioma

giant-cell fibroblastoma sarcoma graft versus host disease bronchiolitis obliterans

gingival overgrowth abdominal aortic aneurysm retinal detachment ring chromosomes

desmoid tumor bullous keratopathy aortic aneurysm diabetic foot ulcers

proliferative vitreoretinopathy bednar's tumor fibrous histiocytoma cavernous malformation

7 diseases from the University of Copenhagen DISEASES database for PDGFB:

Hepatitis E Dermatofibrosarcoma Gastroenteritis Hepatitis

Atherosclerosis Malignant glioma Glomerulonephritis

10/85 Novoseek disease relationships for PDGFB gene (see all 85) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dermatofibrosarcoma protuberans	83.7	13	17431412 (2), 19663837 (2), 20194851 (1), 15681532 (1) (see all 10)
diabetic foot	61.9	15	11548912 (3), 20479444 (2), 20486728 (2), 14652415 (1) (see all 11)
dermatofibrosarcoma	59.8	2	9739023 (1), 15583853 (1)
foot ulcer	56.7	5	18686746 (2), 14652415 (1), 19707423 (1), 10719543 (1)
ulcer	53.7	40	16464208 (4), 9589248 (4), 11075012 (3), 10564562 (3) (see all 17)
glioma	50.4	38	8177392 (6), 1508312 (5), 12651601 (5), 17292826 (3) (see all 14)
glioblastoma	47.6	7	2117995 (1), 1324785 (1), 8789659 (1), 7757303 (1) (see all 6)
gingival overgrowth	44.7	10	9029455 (2), 8708960 (2), 8708959 (1), 8463938 (1)
tumors	44.6	88	7903911 (4), 18758297 (4), 1353485 (3), 2164040 (3) (see all 57)
renal fibrosis	41.7	2	18077793 (1), 14514732 (1)

Genetic Association Database (GAD): PDGFB
Human Genome Epidemiology (HuGE) Navigator: PDGFB (14 documents)

Export disorders for PDGFB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PDGFB gene, integrated from 9 sources (see all 604):
(articles sorted by number of sources associating them with PDGFB)

Utopia: connect your pdf to the dynamic
world of online information

Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation. (PubMed id 1661670)^{1, 2, 3} Clements J.M.... Winslow D. (1991)
Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor. (PubMed id 2991848)^{1, 2, 3} Ratner L.... Wong-Staal F. (1985)
PDGF D, a novel protease-activated growth factor. (PubMed id 11331882)^{1, 2, 9} LaRochelle W.J.... Lichenstein H.S. (2001)
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. (PubMed id 8988177)^{1, 2, 9} Simon M.-P.... Dumanski J.P. (1997)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Dermatofibrosarcoma protuberans of breast. (PubMed id 12660034)^{1, 2} Sandberg A.A.... Hashimoto H. (2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
A novel human c-sis mRNA species is transcribed from a promoter in c- sis intron 1 and contains the code for an alternative PDGF B-like protein. (PubMed id 7659502)^{1, 2} Dirks R.P.... Bloemers H.P. (1995)
Crystal structure of human platelet-derived growth factor BB. (PubMed id 1396586)^{1, 2} Oefner C.... Hosang M. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5155	HGNC: 8800	AceView: PDGFB	Ensembl:ENSG00000100311	euGenes: HUgn5155
ECgene: PDGFB	Kegg: 5155	H-InvDB: PDGFB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PDGFB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PDGFB	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: PDGF	http://www.rndsystems.com/molecule_detail.aspx?m=1967
Regranex	http://www.regranex.com/

Intellectual Property for PDGFB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PDGFB gene:
Search GeneIP for patents involving PDGFB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Cell Line associated with PDGFB: PureStem ES-209, Meso-prx/latp Progenitor

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PDGFB Gene

platelet-derived growth factor beta polypeptide

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PDGFB Gene

platelet-derived growth factor beta polypeptide

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