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Aliases for PDGFA Gene

Aliases for PDGFA Gene

  • Platelet-Derived Growth Factor Alpha Polypeptide 2 3 4
  • Platelet-Derived Growth Factor Alpha Chain 2 3
  • Platelet-Derived Growth Factor A Chain 3 4
  • PDGF Subunit A 3 4
  • PDGF A-Chain 2 3
  • PDGF-1 3 4
  • PDGF1 3 4
  • Platelet-Derived Growth Factor Alpha Isoform 2 Preproprotein 3
  • Platelet-Derived Growth Factor Subunit A 3
  • PDGF-A 3

External Ids for PDGFA Gene

Summaries for PDGFA Gene

Entrez Gene Summary for PDGFA Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDGFA Gene

PDGFA (Platelet-Derived Growth Factor Alpha Polypeptide) is a Protein Coding gene. Diseases associated with PDGFA include tendinitis and denys-drash syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PDGFB.

UniProtKB/Swiss-Prot for PDGFA Gene

  • Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

Tocris Summary for PDGFA Gene

  • Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways.

Gene Wiki entry for PDGFA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFA Gene

Genomics for PDGFA Gene

Genomic Location for PDGFA Gene

Start:
497,258 bp from pter
End:
520,296 bp from pter
Size:
23,039 bases
Orientation:
Minus strand

Genomic View for PDGFA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDGFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFA Gene

Regulatory Elements for PDGFA Gene

Proteins for PDGFA Gene

  • Protein details for PDGFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04085-PDGFA_HUMAN
    Recommended name:
    Platelet-derived growth factor subunit A
    Protein Accession:
    P04085
    Secondary Accessions:
    • B5BU73

    Protein attributes for PDGFA Gene

    Size:
    211 amino acids
    Molecular mass:
    24043 Da
    Quaternary structure:
    • Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.

    Three dimensional structures from OCA and Proteopedia for PDGFA Gene

    Alternative splice isoforms for PDGFA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDGFA Gene

Proteomics data for PDGFA Gene at MOPED

Post-translational modifications for PDGFA Gene

Other Protein References for PDGFA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PDGFA Gene

Domains for PDGFA Gene

Graphical View of Domain Structure for InterPro Entry

P04085

UniProtKB/Swiss-Prot:

PDGFA_HUMAN
Domain:
  • The long form contains a basic insert which acts as a cell retention signal:
    • P04085
Family:
  • Belongs to the PDGF/VEGF growth factor family.:
    • P04085
genes like me logo Genes that share domains with PDGFA: view

No data available for Gene Families for PDGFA Gene

Function for PDGFA Gene

Molecular function for PDGFA Gene

GENATLAS Biochemistry: platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also involved in transformation process
UniProtKB/Swiss-Prot Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

Gene Ontology (GO) - Molecular Function for PDGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005161 platelet-derived growth factor receptor binding IPI 2536956
GO:0005515 protein binding IPI 25241761
GO:0005518 collagen binding IDA 8900172
GO:0008083 growth factor activity IDA 12070119
GO:0042803 protein homodimerization activity IDA 2836953
genes like me logo Genes that share ontologies with PDGFA: view
genes like me logo Genes that share phenotypes with PDGFA: view

Animal Models for PDGFA Gene

MGI Knock Outs for PDGFA:

miRNA for PDGFA Gene

miRTarBase miRNAs that target PDGFA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PDGFA Gene

Localization for PDGFA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFA Gene

Secreted. Note=Released by platelets upon wounding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDGFA Gene COMPARTMENTS Subcellular localization image for PDGFA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 3754619
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005902 microvillus ISS --
genes like me logo Genes that share ontologies with PDGFA: view

Pathways for PDGFA Gene

SuperPathways for PDGFA Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 GPCR Pathway
5 ERK Signaling
genes like me logo Genes that share pathways with PDGFA: view

Gene Ontology (GO) - Biological Process for PDGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001666 response to hypoxia IEA --
GO:0001775 cell activation TAS 10508235
GO:0001942 hair follicle development ISS --
GO:0002053 positive regulation of mesenchymal cell proliferation ISS --
genes like me logo Genes that share ontologies with PDGFA: view

Compounds for PDGFA Gene

(4) Tocris Compounds for PDGFA Gene

Compound Action Cas Number
DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
SU 16f Potent and selective PDGFRbeta inhibitor [251356-45-3]
SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]

(28) Novoseek inferred chemical compound relationships for PDGFA Gene

Compound -log(P) Hits PubMed IDs
ribonucleic acid 49.9 8
vegf 46.7 32
lysophosphatidylcholine 42.2 3
tgf beta1 34.5 5
tyrosine 29.6 4
genes like me logo Genes that share compounds with PDGFA: view

Transcripts for PDGFA Gene

Unigene Clusters for PDGFA Gene

Platelet-derived growth factor alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFA Gene

No ASD Table

Relevant External Links for PDGFA Gene

GeneLoc Exon Structure for
PDGFA
ECgene alternative splicing isoforms for
PDGFA

Expression for PDGFA Gene

mRNA expression in normal human tissues for PDGFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDGFA Gene

This gene is overexpressed in Artery - Aorta (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PDGFA Gene

SOURCE GeneReport for Unigene cluster for PDGFA Gene Hs.535898

genes like me logo Genes that share expressions with PDGFA: view

No data available for mRNA Expression by UniProt/SwissProt for PDGFA Gene

Orthologs for PDGFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDGFA 35
  • 97.14 (n)
  • 96.55 (a)
PDGFA 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDGFA 35
  • 86.7 (n)
  • 86.7 (a)
PDGFA 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDGFA 35
  • 88.95 (n)
  • 89.8 (a)
PDGFA 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdgfa 35
  • 87.76 (n)
  • 92.35 (a)
Pdgfa 16
Pdgfa 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDGFA 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDGFA 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdgfa 35
  • 87.59 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves PDGF-A 36
  • 73 (a)
OneToOne
PDGFA 35
  • 77.32 (n)
  • 79.9 (a)
lizard
(Anolis carolinensis)
Reptilia PDGFA 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia PDGFA 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfa 35
  • 73.9 (n)
  • 76 (a)
Str.20307 35
zebrafish
(Danio rerio)
Actinopterygii pdgfa 35
pdgfaa 35
  • 64.76 (n)
  • 65.14 (a)
pdgfaa 36
  • 59 (a)
OneToMany
pdgfab 36
  • 50 (a)
OneToMany
Species with no ortholog for PDGFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDGFA Gene

ENSEMBL:
Gene Tree for PDGFA (if available)
TreeFam:
Gene Tree for PDGFA (if available)

Paralogs for PDGFA Gene

Paralogs for PDGFA Gene

Selected SIMAP similar genes for PDGFA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PDGFA: view

Variants for PDGFA Gene

Sequence variations from dbSNP and Humsavar for PDGFA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1129401 -- 512,409(+) GTGGC(A/G)TGGAC synonymous-codon, reference
rs1129403 -- 497,345(+) TATTA(A/G)GTAAA utr-variant-3-prime
rs1129404 -- 497,301(+) CAAAA(A/G)AAGAA utr-variant-3-prime
rs1800814 -- 501,104(-) GGCTG(C/T)CTTCG intron-variant, reference, missense
rs2070958 -- 500,881(-) AGGAG(A/G)TTCAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDGFA Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
esv2733620 CNV Deletion 23290073

Relevant External Links for PDGFA Gene

HapMap Linkage Disequilibrium report
PDGFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFA Gene

Disorders for PDGFA Gene

(62) Novoseek inferred disease relationships for PDGFA Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 48.6 1
denys-drash syndrome 44 1
astrocytoma 43 2
medulloblastoma 39.6 2
atherosclerosis 38.3 4

Relevant External Links for PDGFA

Genetic Association Database (GAD)
PDGFA
Human Genome Epidemiology (HuGE) Navigator
PDGFA
genes like me logo Genes that share disorders with PDGFA: view

No data available for UniProtKB/Swiss-Prot for PDGFA Gene

Publications for PDGFA Gene

  1. Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PMID: 1612586) Bonthron D. … Speleman F. (Genomics 1992) 3 4 23
  2. DNA sequence variants of the platelet-derived growth factor A-chain gene. (PMID: 11678848) Baron R. … Drazen J.M. (Clin. Exp. Allergy 2001) 3 23 48
  3. The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PMID: 1505216) Stenman G. … Betsholtz C. (Cytogenet. Cell Genet. 1992) 2 3 23
  4. Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries. (PMID: 18326546) Pinkas H. … Abir R. (Mol. Hum. Reprod. 2008) 3 23
  5. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (PMID: 1317862) Andersson M. … Heldin C.-H. (J. Biol. Chem. 1992) 3 4

Products for PDGFA Gene

Sources for PDGFA Gene

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