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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDGFA Gene

protein-coding   GIFtS: 64
GCID: GC07M000536

Platelet-Derived Growth Factor Alpha Polypeptide

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Platelet-Derived Growth Factor Alpha Polypeptide1 2 3     PDGF12 3
PDGF A-Chain1 2     PDGF Subunit A2 3
Platelet-Derived Growth Factor Alpha Chain1 2     PDGF-A2
Platelet-Derived Growth Factor A Chain2 3     Platelet-Derived Growth Factor Alpha Isoform 2 Preproprotein2
PDGF-12 3     Platelet-Derived Growth Factor Subunit A2

External Ids:    HGNC: 87991   Entrez Gene: 51542   Ensembl: ENSG000001974617   OMIM: 1734305   UniProtKB: P040853   

Export aliases for PDGFA gene to outside databases

Previous GC identifers: GC07U990063 GC07Mh00634 GC07M000503 GC07M000455


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDGFA Gene:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of
this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight
cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth
factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have
shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis;
knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDGFA Gene: 
PDGFA (platelet-derived growth factor alpha polypeptide) is a protein-coding gene. Diseases associated with PDGFA include diffuse mesangial sclerosis, and denys-drash syndrome, and among its related super-pathways are Focal Adhesion and Regulation of actin cytoskeleton. GO annotations related to this gene include growth factor activity and protein homodimerization activity. An important paralog of this gene is PDGFB.

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell
proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required
for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract,
normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and
normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is
modulated by the formation of heterodimers with PDGFB (By similarity)

summary for PDGFA Gene:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDGFA gene promoter:
         Sp1   AP-1   ATF-2   STAT5A   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PDGFA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

PDGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M000536:  view genomic region     (about GC identifiers)

Start:
536,895 bp from pter      End:
559,933 bp from pter
Size:
23,039 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 598,080-651,496     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085 (See protein sequence)
Recommended Name: Platelet-derived growth factor subunit A precursor  
Size: 211 amino acids; 24043 Da
Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked
dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by
PDGFRA and PDGFRB. Interacts with CSPG4
Subcellular location: Secreted. Note=Released by platelets upon wounding
1 PDB 3D structure from and Proteopedia for PDGFA:
3MJK (3D)    
Secondary accessions: B5BU73
Alternative splicing: 2 isoforms:  P04085-1   P04085-2   

Explore the universe of human proteins at neXtProt for PDGFA: NX_P04085

Explore proteomics data for PDGFA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04085

  • PDGFA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDGFA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002598.4  NP_148983.1  

    ENSEMBL proteins: 
     ENSP00000383889   ENSP00000346508   ENSP00000383572   ENSP00000384673  
    Reactome Protein details: P04085
    Human Recombinant Protein Products for PDGFA: 
    EMD Millipore Purified and/or Recombinant PDGFA Protein
    R&D Systems Recombinant & Natural Proteins for PDGFA (PDGF-AA, PDGF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PDGFA
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PDGFA
    GenScript Custom Purified and Recombinant Proteins Services for PDGFA
    Novus Biologicals PDGFA Proteins
    Novus Biologicals PDGFA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PDGFA
    Cloud-Clone Corp. Proteins for PDGFA 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA3754619
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005902microvillus ISS--

    PDGFA for ontologies           About GeneDecksing



    PDGFA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFA
    R&D Systems Antibodies for PDGFA (PDGF-AA, PDGF-A, PDGF)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PDGFA
    GenScript Custom Superior Antibodies Services for PDGFA
    Novus Biologicals PDGFA Antibodies
    Abcam antibodies for PDGFA
    Cloud-Clone Corp. Antibodies for PDGFA 
    ThermoFisher Antibody for PDGFA
    LSBio Antibodies in human, mouse, rat for PDGFA 

    Assay Products for PDGFA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDGFA
    R&D Systems ELISAs for PDGFA (PDGF-AA)         (see all)
    GenScript Custom Assay Services for PDGFA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDGFA 
    Cloud-Clone Corp. CLIAs for PDGFA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR000072 PD_growth_factor
     IPR006782 PDGF_N

    Graphical View of Domain Structure for InterPro Entry P04085

    ProtoNet protein and cluster: P04085

    3 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006782 Platelet-derived growth factor


    UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
    Domain: The long form contains a basic insert which acts as a cell retention signal
    Similarity: Belongs to the PDGF/VEGF growth factor family


    PDGFA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDGFA_HUMAN, P04085
    Function: Growth factor that plays an essential role in the regulation of embryonic development, cell
    proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required
    for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract,
    normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and
    normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is
    modulated by the formation of heterodimers with PDGFB (By similarity)

         Genatlas biochemistry entry for PDGFA:
    platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also
    involved in transformation process

         Summary:
    During embryonic development, PDGFA as signaling molecule
    affects the following cells: Oligodendrocyte Precursor Cells in Medial Ganglionic Eminence, Oligodendrocyte Precursor Cells in Lateral Ganglionic Eminence (see all 5).

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005161platelet-derived growth factor receptor binding IPI2536956
    GO:0005518collagen binding IDA8900172
    GO:0008083growth factor activity IEA--
    GO:0042803protein homodimerization activity IDA2836953
    GO:0046982protein heterodimerization activity IPI7073684
         
    PDGFA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDGFA:
     Increased cell number in G2M,  

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pdgfa):
     cardiovascular system  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  muscle  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton 

    PDGFA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdgfatm1Cbet for PDGFA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDGFA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDGFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDGFA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDGFA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDGFA:
    hsa-let-7d (MIRT005549)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFA
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFA (see all 38):
    hsa-miR-411* hsa-miR-379* hsa-miR-4328 hsa-miR-374c hsa-miR-3150b-3p hsa-miR-186 hsa-miR-34b hsa-miR-23a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PDGFA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDGFA
    Sirion Biotech Customized adenovirus for overexpression of PDGFA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PDGFA (see all 11)
    OriGene ORF clones in mouse, rat for PDGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDGFA (NM_002607)
    Sino Biological Human cDNA Clone for PDGFA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFA
    Sirion Biotech Customized lentivirus for stable overexpression of PDGFA 
                         Customized lentivirus expression plasmids for stable overexpression of PDGFA 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PDGFA
    Search LifeMap BioReagents cell lines for PDGFA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDGFA About   (see all 45)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    5PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for PDGFA
        Development PDGF signaling via MAPK cascades
    Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDGFA (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    3 GeneGo (Thomson Reuters) Pathways for PDGFA
        Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development PDGF signaling via MAPK cascades

    5 BioSystems Pathways for PDGFA
        Focal Adhesion
    Cytokines and Inflammatory Response
    Regulation of Actin Cytoskeleton
    Integrated Pancreatic Cancer Pathway
    Ceramide signaling pathway


    5/37        Reactome Pathways for PDGFA (see all 37)
        Signaling by EGFR in Cancer
    Extracellular matrix organization
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF


    5/13         Kegg Pathways  (Kegg details for PDGFA) (see all 13):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Focal adhesion
    Gap junction


    PDGFA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for PDGFA (P040853 ENSP000003465084) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPARCP094863, ENSP000002310614I2D: score=3 STRING: ENSP00000231061
    FURINP099583, ENSP000002681714I2D: score=2 STRING: ENSP00000268171
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    PDGFBP011273, ENSP000003303824I2D: score=1 STRING: ENSP00000330382
    PDGFRAP162343, ENSP000002572904I2D: score=3 STRING: ENSP00000257290
    About this table

    Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0001666response to hypoxia IEA--
    GO:0001775cell activation TAS10508235
    GO:0001942hair follicle development ISS--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--

    PDGFA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDGFA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDGFA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    SU 16fPotent and selective PDGFRbeta inhibitor[251356-45-3]

    10/28 Novoseek inferred chemical compound relationships for PDGFA gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 49.9 10 12153981 (1), 1651380 (1), 8697155 (1), 9482185 (1) (see all 8)
    vegf 46.7 34 18592007 (4), 9486038 (3), 15334938 (3), 16103054 (3) (see all 21)
    lysophosphatidylcholine 42.2 3 10865829 (1), 10588364 (1), 7641323 (1)
    tgf beta1 34.5 5 15682418 (3), 15498125 (1), 19706334 (1)
    tyrosine 29.6 4 15061151 (1), 16689459 (1), 18084259 (1), 12651221 (1)
    pd 98,059 28.8 1 10446131 (1)
    cycloheximide 26.1 2 8427857 (1), 1694856 (1)
    cystine 25.4 1 8179329 (1)
    procollagen 22.8 1 7806036 (1)
    oligonucleotide 17.5 2 11823426 (1), 8780387 (1)

    Search CenterWatch for drugs/clinical trials and news about PDGFA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDGFA gene (2 alternative transcripts): 
    NM_002607.5  NM_033023.4  

    Unigene Cluster for PDGFA:

    Platelet-derived growth factor alpha polypeptide
    Hs.535898  [show with all ESTs]
    Unigene Representative Sequence: NM_002607
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402802(uc003sir.3 uc003sis.3) ENST00000354513 ENST00000400761
    ENST00000482462(uc003sit.1) ENST00000405692 ENST00000426681

    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFA (see all 38):
    hsa-miR-411* hsa-miR-379* hsa-miR-4328 hsa-miR-374c hsa-miR-3150b-3p hsa-miR-186 hsa-miR-34b hsa-miR-23a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFA
    Clone
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    OriGene clones in human, mouse for PDGFA (see all 11)
    OriGene ORF clones in mouse, rat for PDGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDGFA (NM_002607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFA
    Sirion Biotech Customized lentivirus for stable overexpression of PDGFA 
                         Customized lentivirus expression plasmids for stable overexpression of PDGFA 
    Primer
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    OriGene qPCR primer pairs and template standards for PDGFA
    OriGene qSTAR qPCR primer pairs in human, mouse for PDGFA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDGFA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDGFA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFA

    Additional mRNA sequence: 

    AB451309.1 AB451439.1 AK292217.1 BC109246.1 X03795.1 X06374.1 

    3 DOTS entries:

    DT.95265064  DT.87077343  DT.95069591 

    24/25 AceView cDNA sequences (see all 25):

    H89543 BM142229 BM702563 AA403247 H89357 AI276565 CK820161 BQ001096 
    AI633869 AI934350 AI625002 BM693414 BQ002008 AV729452 AW118697 AA770172 
    BE503326 AI651133 BQ366054 NM_033023 X06374 BF094250 BM787770 NM_002607 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDGFA expression in normal human tissues (normalized intensities)      PDGFA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATACCTAC
    PDGFA Expression
    About this image


    PDGFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             sensory organ/nose/naso-lacrimal duct   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Metanephros
             mK3
             visceral organ/mesonephros/mesonephric tubule   
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 4 entries
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             sensory organ/eye/conjunctival sac   

    See PDGFA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDGFA

    SOURCE GeneReport for Unigene cluster: Hs.535898
        SABiosciences Expression via Pathway-Focused PCR Arrays including PDGFA (see all 10): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Wound Healing in human mouse rat
              Angiogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PDGFA gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdgfa1 , 5 platelet derived growth factor, alpha1, 5 87.76(n)1
    92.35(a)1
      5 (77.65 cM)5
    185901  NM_008808.31  NP_032834.11 
     1389760145 
    chicken
    (Gallus gallus)
    Aves PDGFA1 platelet-derived growth factor alpha polypeptide 77.32(n)
    79.9(a)
      374196  NM_204306.1  NP_989637.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDGFA6
    platelet-derived growth factor alpha polypeptide
    62(a)
    1 ↔ 1
    GL343385.1(540924-555309)
    African clawed frog
    (Xenopus laevis)
    Amphibia PDGFA2 platelet-derived growth factor A chain, long form 77.46(n)    M23238.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdgfa2 platelet-derived growth factor alpha polypeptide 79.75(n)   378480  AF200950.1 


    ENSEMBL Gene Tree for PDGFA (if available)
    TreeFam Gene Tree for PDGFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDGFA gene
    PDGFB2  
    1 SIMAP similar gene for PDGFA using alignment to 4 protein entries:     PDGFA_HUMAN (see all proteins):
    PDGFB

    PDGFA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/625 SNPs in PDGFA are shown (see all 625)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127200311,2
    C,F--536416(+) CCTTCG/ATAAGA 2 -- ds50014Minor allele frequency- A:0.50NA WA CSA 8
    rs127200321,2
    C,F--536424(+) AGAACC/ATTCCA 2 -- ds50014Minor allele frequency- A:0.50NA WA CSA 8
    rs789756231,2
    C--536461(+) CGGCCA/GCCAGT 2 -- ds50010--------
    rs1399955271,2
    --536488(+) AAGAAC/TGCGGG 2 -- ds50010--------
    rs1857028421,2
    --536565(+) GGCAGG/TGTATG 2 -- ds50010--------
    rs96918321,2
    C--536598(+) CCAAGT/ACAGGT 2 -- ds50018Minor allele frequency- A:0.08NA WA CSA 13
    rs1904309291,2
    --536632(+) CTTCAC/TGGTCT 2 -- ds50010--------
    rs1402272581,2
    --536700(+) CCTCGC/GCCTAA 2 -- ds50010--------
    rs1439696751,2
    C--536726(+) AAGTCC/TGAGGT 2 -- ds50010--------
    rs1449587761,2
    C--536727(+) AGTCCC/GAGGTA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PDGFA (536895 - 559933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PDGFA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733620CNV Deletion23290073
    nsv887128CNV Loss21882294
    dgv7078n71CNV Loss21882294
    dgv7074n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173430    OMIM disorders: --

    20/91 diseases for PDGFA (see all 91):    About MalaCards
    diffuse mesangial sclerosis    denys-drash syndrome    ureteral obstruction    desmoplastic small round cell tumor
    renovascular hypertension    renal dysplasia    uterine fibroid    myxoid liposarcoma
    bone fracture    central nervous system lymphoma    pleomorphic adenoma    pulmonary fibrosis
    ependymoma    retinal detachment    pilocytic astrocytoma    merkel cell carcinoma
    arteriosclerosis    essential thrombocythemia    idiopathic pulmonary fibrosis    oligodendroglioma


    PDGFA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/62 Novoseek inferred disease relationships for PDGFA gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 48.6 1 11322447 (1)
    denys-drash syndrome 44 1 10586431 (1)
    astrocytoma 43 3 7829210 (1), 11322447 (1)
    medulloblastoma 39.6 2 8841077 (1), 11544480 (1)
    atherosclerosis 38.3 4 11838000 (1), 18573494 (1), 15517943 (1), 9888867 (1)
    tumors 34.8 61 15389255 (6), 8619189 (3), 7923179 (3), 19628565 (2) (see all 33)
    atherosclerotic plaque 34.8 2 8653829 (1), 7914837 (1)
    oligodendroglioma 33.7 2 9482185 (1), 11322447 (1)
    osteosarcoma 27.3 2 2156959 (1), 2016070 (1)
    glioma 26.9 9 19707201 (5), 9402177 (1), 2016070 (1), 9049853 (1)

    Genetic Association Database (GAD): PDGFA
    Human Genome Epidemiology (HuGE) Navigator: PDGFA (3 documents)

    Export disorders for PDGFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDGFA gene, integrated from 9 sources (see all 408):
    (articles sorted by number of sources associating them with PDGFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PubMed id 1612586)1, 2, 9 Bonthron D.... Speleman F. (1992)
    2. DNA sequence variants of the platelet-derived growth factor A-chain gene. (PubMed id 11678848)1, 4, 9 Baron R....Drazen J.M. (2001)
    3. The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PubMed id 1505216)1, 3, 9 Stenman G....Betsholtz C. (1992)
    4. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    5. Structures of a platelet-derived growth factor/propep tide complex and a platelet-derived growth factor/receptor complex. (PubMed id 20534510)1, 2 Shim A.H....He X. (2010)
    6. High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. (PubMed id 10358027)1, 2 Goretzki L.... Stallcup W.B. (1999)
    7. Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene. (PubMed id 8486521)1, 2 Takimoto Y.... Deuel T.F. (1993)
    8. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (PubMed id 1317862)1, 2 Andersson M.... Heldin C.-H. (1992)
    9. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. (PubMed id 2536956)1, 3 Matsui T.... Aaronson S. (1989)
    10. Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. (PubMed id 2832727)1, 2 Rorsman F.... Betsholtz C. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5154 HGNC: 8799 AceView: PDGFA Ensembl:ENSG00000197461 euGenes: HUgn5154
    ECgene: PDGFA Kegg: 5154 H-InvDB: PDGFA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDGFA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFA Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: PDGFhttp://www.rndsystems.com/molecule_detail.aspx?m=1967

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDGFA gene:
    Search GeneIP for patents involving PDGFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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