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PDGFA Gene

protein-coding GIFtS: 65

GC07M000503

platelet-derived growth factor alpha polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
PDGF-1 ^³
PDGF-A ^¹, ²
PDGF1 ^¹, ², ³

Descriptions
PDGF A-chain ^²
PDGF subunit A ^³
Platelet-derived growth factor A chain ^³
platelet-derived growth factor alpha ^²
platelet-derived growth factor alpha chain ^²
platelet-derived growth factor alpha isoform 2 preproprotein ^²
platelet-derived growth factor alpha polypeptide ^², ³

External Ids
HGNC: 8799¹
Entrez Gene: 5154²
UniProtKB: P04085³
Ensembl: ENSG00000197461⁷

Search outside databases for aliases for PDGFA gene

Previous GC identifers: GC07U990063 GC07Mh00634

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PDGFA:

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four

members of this family are mitogenic factors for cells of mesenchymal origin and are characterized

by a motif of eight cysteines. This gene product can exist either as a homodimer or as a

heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are

connected by disulfide bonds. Studies using knockout mice have shown cellular defects in

oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die

either as embryos or shortly after birth. Two splice variants have been identified for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085

Function: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin.

Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It

is released by platelets upon wounding and plays an important role in stimulating adjacent cells

to grow and thereby heals the wound

Gene Wiki entry for PDGFA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDGFA gene

Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22

PDGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M000503: (about GC identifiers)

Start:	503,421 bp from pter
End:	526,459 bp from pter
Size:	23,039 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 598,080-620,018

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085 (See protein sequence)

Recommended Name: Platelet-derived growth factor subunit A precursor

Size: 211 amino acids; 24043 Da

Subunit: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and

B chains are implicated in transformation processes. Interacts with CSPG4

Subcellular location: Secreted

Miscellaneous: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor

Secondary accessions: B5BU73

Alternative splicing: 2 isoforms: P04085-1 P04085-2

REFSEQ proteins (2 alternative transcripts):

NP_002598.4 NP_148983.1

ENSEMBL proteins:

ENSP00000384673 ENSP00000345559 ENSP00000346508 ENSP00000383889

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PDGFA
	Millipore Purified and/or Recombinant PDGFA Protein
	Sigma-Aldrich Proteins for PDGFA
	R&D Systems Recombinant & Natural Proteins for PDGFA (PDGF-AA, PDGF)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PDGF AB + BB, PDGFAA + PDGFBB, PDGF AA, PDGF AB)
	Human Recombinant Proteins from Abnova (PDGFA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	3754619
GO:0009986	cell surface	IDA	291037 2836953
GO:0016020	membrane	IEA	--
GO:0031089	platelet dense granule lumen	EXP	287022

About this table

Antibodies for PDGFA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PDGFA
	Sigma-Aldrich Antibodies for PDGFA
	R&D Systems Antibodies for PDGFA (PDGF-AA, PDGF-A, PDGF)
	Antibodies from Abcam (PDGF AB + BB, PDGFAA + PDGFBB, PDGF AA, PDGF AB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDGFA)
	Novus Biologicals Antibodies for PDGFA

Assays for PDGFA:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of PDGFA
	R&D Systems ELISAs for PDGFA (PDGF-AA) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04085

ProtoNet protein and cluster: P04085

3 Blocks protein families:

IPB000072 Platelet-derived growth factor (PDGF)

IPB002400 Growth factor cystine knot superfamily signature

IPB006782 Platelet-derived growth factor

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085

Domain: The long form contains a basic insert which acts as a cell retention signal

Similarity: Belongs to the PDGF/VEGF growth factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDGFA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDGFA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002607

Applied Biosystems Silencer® siRNAs for PDGFA

Sigma-Aldrich siRNA and siRNA Panels for PDGFA

Sigma-Aldrich shRNA for PDGFA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PDGFA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002607
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002607
untagged cDNA clones in CMV expression vector (see all 2): NM_002607

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002607

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085

Function: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin.

Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It

is released by platelets upon wounding and plays an important role in stimulating adjacent cells

to grow and thereby heals the wound

Genatlas biochemistry entry for PDGFA:

platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal

origin,also involved in transformation process

14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pdgfa):

	craniofacial	embryogenesis	growth/size	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	muscle	nervous system	renal/urinary system
reproductive system	respiratory system	skeleton	skin/coat/nails

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005161	platelet-derived growth factor receptor binding	IPI	2536956
GO:0005518	collagen binding	IDA	8900172
GO:0008083	growth factor activity	IEA	--
GO:0042803	protein homodimerization activity	IDA	2836953 3754619
GO:0043498	cell surface binding	IDA	291037 2538439 2836953

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for PDGFA (Your Favorite Gene powered by Ingenuity) (see all 11 )

Macropinocytosis
PPAR Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
VDR/RXR Activation
Ephrin Receptor Signaling

GeneDecks PDGFA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PDGFA

5/121 Interacting proteins for PDGFA (ENSP00000346508³) via UniProtKB, MINT, and/or STRING (see all 121 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLCG1	ENSP00000362369³	STRING (score=.995)
EGF	ENSP00000265171³	STRING (score=.994)
PDGFRB	ENSP00000261799³	STRING (score=.994)
IGF1R	ENSP00000268035³	STRING (score=.979)
FURIN	ENSP00000268171³	STRING (score=.976)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001775	cell activation	TAS	10508235
GO:0007267	cell-cell signaling	TAS	2842868
GO:0009790	embryonic development	TAS	10508235
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	IDA	2538439
GO:0010544	negative regulation of platelet activation	IDA	2538439

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PDGFA

Sigma-Aldrich Small Molecules for PDGFA:

Inhibitor

Compounds for PDGFA available from Tocris Bioscience

Compound	Action	CAS number
AG 213	EGFR/PDGFR-kinase inhibitor	[122520-86-9]
DMPQ dihydrochloride	Potent, selective inhibitor of beta-type PDGFR	[137206-97-4]
AG 18	EGFR/PDGFR-kinase inhibitor	[118409-57-7]

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10/18 Novoseek chemical compound relationships for PDGFA gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ribonucleic acid	50.74	10	12153981 (1), 1651380 (1), 8697155 (1), 9482185 (1) (see all 8)
lysophosphatidylcholine	43.46	3	10865829 (1), 10588364 (1), 7641323 (1)
pd 98,059	30.26	1	10446131 (1)
tyrosine	29.63	4	15061151 (1), 16689459 (1), 18084259 (1), 12651221 (1)
tgf beta1	27.69	4	15682418 (3), 15498125 (1)
cystine	26.86	1	8179329 (1)
procollagen	24.09	1	7806036 (1)
12-o-tetradecanoylphorbol 13-acetate	17.72	1	7869830 (1)
oligonucleotide	15.04	2	11823426 (1), 8780387 (1)
phosphatidylinositol	11.34	3	1310684 (2), 10446131 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDGFA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDGFA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002607

Sigma-Aldrich siRNA and siRNA Panels for PDGFA

Sigma-Aldrich shRNA for PDGFA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002607 NM_033023

REFSEQ mRNAs for PDGFA gene (2 alternative transcripts):

NM_002607.5 NM_033023.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002607 NM_033023

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002607
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002607
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002607

Additional cDNA sequence:

AB451309.1 AB451439.1 AK292217.1 BC109246.1 X03795.1 X06374.1

2 DOTS entries:

DT.95265064 DT.87077343

24/25 AceView cDNA sequences (see all 25 ):

H89357 BM702563 H89543 AA403247 CK820161 BM142229 AI276565 BM693414

AV729452 BQ002008 AI633869 AA770172 AI934350 BE503326 BQ001096 AW118697

AI625002 AI651133 BQ366054 X06374 NM_033023 BF094250 NM_002607 BM787770

highest scoring ESTs for PDGFA:

X06374 AU118732 BF771483 BE315078 BE336646 BF771485 BG108753 BI010649 BQ315460 CN268067

Unigene Cluster for PDGFA:

Platelet-derived growth factor alpha polypeptide

Hs.535898 [show with all ESTs]

Unigene Representative Sequence: NM_002607

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000405692 ENST00000344323 ENST00000354513 ENST00000402802

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PDGFA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDGFA

¹ / ² / ³

6 probe-sets matching PDGFA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35703_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.44	X06374	1.00	1.00	1.00	1
1109_s_at²^{, 3}	U95-A	2	1.00	0.66	0.17	0.58	M19989	0.20	1.00	0.72	1
205463_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002607	0.40	1.00	0.76	1
216867_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	X03795	0.60	1.00	0.82	1
205463_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216867_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks PDGFA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTATACCTAC

SOURCE GeneReport for Unigene cluster: Hs.535898
Expression variation in blood from EXPOLDB for PDGFA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDGFA gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDGFA¹	--	platelet-derived growth factor alpha polypeptide	89.57(n) 90.05(a)	491597 XM_843505.1 XP_848598.1
cow (Bos taurus)	PDGFA¹	--	platelet-derived growth factor alpha polypeptide	87.36(n) 86.73(a)	505908 NM_001075231.1 NP_001068699.1
rat (Rattus norvegicus)	Pdgfa¹	--	platelet-derived growth factor alpha polypeptide	87.39(n) 91.19(a)	25266 NM_012801.1 NP_036933.1
mouse (Mus musculus)	Pdgfa^{1, 5}	5 (82.00 cM)⁵	platelet derived growth factor, alpha^{1, 5}	87.56(n)¹ 92.23(a)¹	18590¹ NM_008808.3¹ NP_032834.1¹ AI835646⁵ AK017169⁵ (see all 19)
chicken (Gallus gallus)	PDGFA¹	--	platelet-derived growth factor alpha polypeptide	77.2(n) 79.79(a)	374196 NM_204306.1 NP_989637.1

About this table Species with no ortholog for PDGFA

ENSEMBL Gene Tree for PDGFA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PDGFA gene

PDGFB² LOC729619²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/99 NCBI SNPs in PDGFA are shown (see all 99 )

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs9719231^1,2	C	527596(+)	`AACTTG/TCGGCT`	2	--	ng3¹		0	--	--	--	--
--	rs9691832^1,2	C	503124(+)	`CCAAGA/TCAGGT`	2	--	ng5¹		0	--	--	--	--
--	rs2070958^1,2	C,F	507044(-)	`AGGAGA/GTTCAG`	2	--	int¹		1		EA	1470
--	rs9986730^1,2	C	512135(+)	`agttcA/Cagacc`	2	--	int¹		0	--	--	--	--
--	rs9691628^1,2	C	509076(+)	`CCCCCC/GACCAG`	2	--	int¹		0	--	--	--	--
--	rs9718477^1,2	C	512497(+)	`ATCCAC/TTAAGA`	2	--	int¹		0	--	--	--	--
--	rs12720025^1,2	F	504874(+)	`TTTCAA/TGAAAT`	2	--	int¹		4		NA EA	362
--	rs9691780^1,2	C	509354(+)	`TCCCAC/TCTGCC`	2	--	int¹		0	--	--	--	--
--	rs9692058^1,2	C	509091(+)	`GCATGC/TGTAAT`	2	--	int¹		0	--	--	--	--
--	rs9692477^1,2	C	506684(+)	`AGGGCA/GGTGAG`	2	--	int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for PDGFA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 173430

10/62 Novoseek disease relationships for PDGFA gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	48.67	1	11322447 (1)
denys-drash syndrome	44.73	1	10586431 (1)
astrocytoma	41.49	3	7829210 (1), 11322447 (1)
medulloblastoma	41.14	2	8841077 (1), 11544480 (1)
atherosclerosis	39.99	4	11838000 (1), 18573494 (1), 15517943 (1), 9888867 (1)
atherosclerotic plaque	36.57	2	8653829 (1), 7914837 (1)
oligodendroglioma	35.15	2	9482185 (1), 11322447 (1)
tumors	34.35	57	15389255 (6), 8619189 (3), 7923179 (3), 17074177 (2) (see all 30)
osteosarcoma	28.80	2	2156959 (1), 2016070 (1)
fibrosis idiopathic pulmonary	28.38	1	8520779 (1)

About this table

Genetic Association Database: PDGFA
Human Genome Epidemiology Navigator: PDGFA (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/355 PubMed articles for PDGFA gene (see all 355 ):

Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PubMed id 1612586)^{1, 3, 4} Bonthron D.... Speleman F. (1992)
DNA sequence variants of the platelet-derived growth factor A-chain gene. (PubMed id 11678848)^{1, 3, 6} Baron R....Drazen J.M. (2001)
The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PubMed id 1505216)^{1, 2, 3} Stenman G....Betsholtz C. (1992)
High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. (PubMed id 10358027)^{3, 4} Goretzki L.... Stallcup W.B. (1999)
Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene. (PubMed id 8486521)^{3, 4} Takimoto Y.... Deuel T.F. (1993)
Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (PubMed id 1317862)^{3, 4} Andersson M.... Heldin C.-H. (1992)
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. (PubMed id 2536956)^{2, 3} Matsui T....Aaronson S. (1989)
Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. (PubMed id 2832727)^{3, 4} Rorsman F.... Betsholtz C. (1988)
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. (PubMed id 3422746)^{3, 4} Bonthron D.T.... Collins T. (1988)
Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. (PubMed id 3614364)^{3, 4} Collins T.... Orkin S.H. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5154	HGNC: 8799	AceView: PDGFA	Ensembl:ENSG00000197461	euGenes: HUgn5154
ECgene: PDGFA	H-InvDB: PDGFA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PDGFA	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine mini-reviews: PDGF	http://www.rndsystems.com/molecule_detail.aspx?m=1967

Licensable Technologies for PDGFA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PDGFA:

TaqMan ® Gene Expression Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDGFA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDGFA		Antibodies for PDGFA
	Explore super-pooled esiRNAs		Proteins for PDGFA
	Lentivirus-delivered shRNAs for PDGFA		Small molecules for PDGFA
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for PDGFA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PDGFA Gene at Home site.
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PDGFA Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for PDGFA

Summaries
for PDGFA

Genomic Location
for PDGFA

Proteins
for PDGFA

Protein Domains/
Families
for PDGFA

Gene Function
for PDGFA

Pathways & Interactions
for PDGFA

Drugs & Compounds
for PDGFA

Transcripts
for PDGFA

Expression
for PDGFA

Orthologs
for PDGFA

Paralogs
for PDGFA

SNPs/Variants
for PDGFA

Disorders & Mutations
for PDGFA

Medical News
for PDGFA

Publications
for PDGFA

Search for PDGFA

Genome Databases showing PDGFA

Other Databases showing PDGFA

Specialized Databases showing PDGFA

Licensable Technologies
for PDGFA

Services
for PDGFA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDGFA Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor PDGFA

Summariesfor PDGFA

Genomic Locationfor PDGFA

Proteinsfor PDGFA

Protein Domains/Familiesfor PDGFA

Gene Functionfor PDGFA

Pathways & Interactionsfor PDGFA

Drugs & Compoundsfor PDGFA

Transcriptsfor PDGFA

Expression for PDGFA

Orthologsfor PDGFA

Paralogsfor PDGFA

SNPs/Variantsfor PDGFA

Disorders & Mutationsfor PDGFA

Medical Newsfor PDGFA

Publicationsfor PDGFA

Search for PDGFA

Genome Databases showing PDGFA

Other Databases showing PDGFA

Specialized Databases showing PDGFA

Licensable Technologiesfor PDGFA

Servicesfor PDGFA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDGFA

Summaries
for PDGFA

Genomic Location
for PDGFA

Proteins
for PDGFA

Protein Domains/
Families
for PDGFA

Gene Function
for PDGFA

Pathways & Interactions
for PDGFA

Drugs & Compounds
for PDGFA

Transcripts
for PDGFA

Expression
for PDGFA

Orthologs
for PDGFA

Paralogs
for PDGFA

SNPs/Variants
for PDGFA

Disorders & Mutations
for PDGFA

Medical News
for PDGFA

Publications
for PDGFA

Licensable Technologies
for PDGFA

Services
for PDGFA