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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDGFA Gene

protein-coding   GIFtS: 64
GCID: GC07M000536

platelet-derived growth factor alpha polypeptide
 Explore 95 diseases affiliated with
PDGFA via
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Biological research products
for PDGFA    

Aliases
for PDGFA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Platelet-Derived Growth Factor Alpha Polypeptide1 2 3     PDGF Subunit A2 3
PDGF11 2 3     PDGF A-Chain2
PDGF-A1 2     Platelet-Derived Growth Factor Alpha Chain2
Platelet-Derived Growth Factor A Chain2 3     Platelet-Derived Growth Factor Alpha Isoform 2 Preproprotein2
PDGF-12 3     Platelet-Derived Growth Factor Subunit A2

External Ids:    HGNC: 87991   Entrez Gene: 51542   Ensembl: ENSG000001974617   OMIM: 1734305   UniProtKB: P040853   

Export aliases for PDGFA gene to outside databases

Previous GC identifers: GC07U990063 GC07Mh00634 GC07M000503 GC07M000455


Summaries
for PDGFA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDGFA:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this
family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This
gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta
polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular
defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as
embryos or shortly after birth. Two splice variants have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation,
cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung
alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development
of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the
spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of
heterodimers with PDGFB (By similarity)

summary for PDGFA:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFA


Genomic Views
for PDGFA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDGFA gene promoter:
         Sp1   AP-1   ATF-2   STAT5A   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PDGFA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

PDGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M000536:  view genomic region     (about GC identifiers)

Start:
 536,895 bp from pter      End:
 559,933 bp from pter
Size:
 23,039 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 598,080-651,496     

Proteins
for PDGFA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085 (See protein sequence)
Recommended Name: Platelet-derived growth factor subunit A precursor  
Size: 211 amino acids; 24043 Da
Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer.
The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The
heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and
PDGFRB. Interacts with CSPG4
Subcellular location: Secreted. Note=Released by platelets upon wounding
1 PDB 3D structure from and Proteopedia for PDGFA:
3MJK (3D)    
Secondary accessions: B5BU73
Alternative splicing: 2 isoforms:  P04085-1   P04085-2   

Explore the universe of human proteins at neXtProt for PDGFA: NX_P04085

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04085

    • PDGFA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002598.4  NP_148983.1  

    ENSEMBL proteins: 
     ENSP00000383889   ENSP00000346508   ENSP00000383572   ENSP00000388418   ENSP00000384673  
    Reactome Protein details: P04085
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PDGFA Protein
    R&D Systems Recombinant & Natural Proteins for PDGFA (PDGF-AA, PDGF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): PDGFA
    OriGene Custom Protein Services for PDGFA 
    GenScript Custom Purified and Recombinant Proteins Services for PDGFA
    Novus Biologicals PDGFA Proteins
    Novus Biologicals PDGFA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PDGFA
    Uscn Proteins for PDGFA

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA3754619
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005902microvillus ISS--


    PDGFA for ontologies           About GeneDecksing



    PDGFA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFA
    R&D Systems Antibodies for PDGFA (PDGF-AA, PDGF-A, PDGF)
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    Novus Biologicals PDGFA Antibodies
    Abcam antibodies for PDGFA 
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    ThermoFisher Antibodies for PDGFA

    Assay Products for PDGFA: 
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    OriGene Custom Immunoassay Development
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    R&D Systems ELISAs for PDGFA (PDGF-AA)         (see all)
    GenScript Custom Assay Services for PDGFA
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PDGFA

    Protein Domains /
    Families
    for PDGFA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDGFA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023581 PD_growth_factor_CS
     IPR000072 PD_growth_factor
     IPR006782 PDGF_N

    Graphical View of Domain Structure for InterPro Entry P04085

    ProtoNet protein and cluster: P04085

    3 Blocks protein families:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006782 Platelet-derived growth factor


    UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
    Domain: The long form contains a basic insert which acts as a cell retention signal
    Similarity: Belongs to the PDGF/VEGF growth factor family


    Function
    for PDGFA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
    Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation,
    cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung
    alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development
    of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the
    spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of
    heterodimers with PDGFB (By similarity)

         Genatlas biochemistry entry for PDGFA:
    platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also involved in
    transformation process

    miRNA
    Products:            		miRTarBase miRNAs that target PDGFA:
    hsa-let-7d (MIRT005549)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFA
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFA (see all 38):
    hsa-miR-411* hsa-miR-379* hsa-miR-4328 hsa-miR-374c hsa-miR-3150b-3p hsa-miR-186 hsa-miR-34b hsa-miR-23a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFA (see all 7)
    OriGene shRNA RFP: PDGFA
    OriGene siRNA: PDGFA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDGFA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFA (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PDGFA (NM_002607)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PDGFA
    Search LifeMap BioReagents cell lines for PDGFA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFA

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005161platelet-derived growth factor receptor binding IPI2536956
    GO:0005518collagen binding IDA8900172
    GO:0008083growth factor activity IEA--
    GO:0042803protein homodimerization activity IDA2836953
    GO:0043498cell surface binding IDA2538439


    PDGFA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PDGFA:
     Increased cell number in G2M,  

    Animal Models:
         Mouse knock-out Pdgfatm1Cbet for PDGFA
         13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pdgfa):
     cardiovascular system  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  muscle  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton 

    PDGFA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDGFA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    4GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PDGFA
        Development PDGF signaling via MAPK cascades
    Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDGFA (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    3 GeneGo (Thomson Reuters) Pathways for PDGFA
        Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development PDGF signaling via MAPK cascades

    5/6 BioSystems Pathways for PDGFA (see all 6) 
        Focal Adhesion
    Cytokines and Inflammatory Response
    Regulation of Actin Cytoskeleton
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    5/35        Reactome Pathways for PDGFA (see all 35)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)


    5/9         Kegg Pathways  (Kegg details for PDGFA) (see all 9):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Focal adhesion
    Gap junction
    Regulation of actin cytoskeleton


    PDGFA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for PDGFA (P040853 ENSP000003465084) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPARCP094863, ENSP000002310614I2D: score=3 STRING: ENSP00000231061
    FURINP099583, ENSP000002681714I2D: score=2 STRING: ENSP00000268171
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    PDGFBP011273, ENSP000003303824I2D: score=1 STRING: ENSP00000330382
    PDGFRAP162343, ENSP000002572904I2D: score=3 STRING: ENSP00000257290
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0001666response to hypoxia IEA--
    GO:0001775cell activation TAS10508235
    GO:0001942hair follicle development ISS--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--


    PDGFA for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDGFA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDGFA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDGFA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    AG 18EGFR/PDGFR-kinase inhibitor[118409-57-7]
    10/28 Novoseek chemical compound relationships for PDGFA gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 49.9 10 12153981 (1), 1651380 (1), 8697155 (1), 9482185 (1) (see all 8)
    vegf 46.7 34 18592007 (4), 9486038 (3), 15334938 (3), 16103054 (3) (see all 21)
    lysophosphatidylcholine 42.2 3 10865829 (1), 10588364 (1), 7641323 (1)
    tgf beta1 34.5 5 15682418 (3), 15498125 (1), 19706334 (1)
    tyrosine 29.6 4 15061151 (1), 16689459 (1), 18084259 (1), 12651221 (1)
    pd 98,059 28.8 1 10446131 (1)
    cycloheximide 26.1 2 8427857 (1), 1694856 (1)
    cystine 25.4 1 8179329 (1)
    procollagen 22.8 1 7806036 (1)
    oligonucleotide 17.5 2 11823426 (1), 8780387 (1)

    Search CenterWatch for drugs/clinical trials and news about PDGFA 

    Transcripts
    for PDGFA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDGFA gene (2 alternative transcripts): 
    NM_002607.5  NM_033023.4  

    Unigene Cluster for PDGFA:

    Platelet-derived growth factor alpha polypeptide
    Hs.535898  [show with all ESTs]
    Unigene Representative Sequence: NM_002607
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402802(uc003sir.3 uc003sis.3) ENST00000354513 ENST00000482462(uc003sit.1)
    ENST00000400761 ENST00000426681 ENST00000405692

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDGFA
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PDGFA (see all 38):
    hsa-miR-411* hsa-miR-379* hsa-miR-4328 hsa-miR-374c hsa-miR-3150b-3p hsa-miR-186 hsa-miR-34b hsa-miR-23a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDGFA (see all 7)
    OriGene shRNA RFP: PDGFA
    OriGene siRNA: PDGFA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDGFA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFA (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDGFA (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PDGFA (NM_002607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDGFA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDGFA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDGFA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDGFA

    Additional cDNA sequence: 

    AB451309.1 AB451439.1 AK292217.1 BC109246.1 X03795.1 X06374.1 

    3 DOTS entries:

    DT.95265064  DT.87077343  DT.95069591 

    24/25 AceView cDNA sequences (see all 25):

    H89543 CK820161 AA403247 BM702563 H89357 AI276565 BM142229 AI934350 
    BM693414 BQ002008 AA770172 AV729452 BQ001096 AI633869 AI625002 AW118697 
    BE503326 AI651133 BQ366054 NM_033023 BF094250 X06374 NM_002607 BM787770 

    GeneLoc Exon Structure


    Expression
    for PDGFA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDGFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATACCTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PDGFA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)MorulaMorula CellsEarly Embryo
    Early Embryo (Zygote)ZygoteZygoteEarly Embryo
    HypoblastHypoblastParietal Endoderm CellsExtraembryonic Tissues
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    TestisSeminiferous TubulesSertoli cellsTestis
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    BrainChoroid PlexusBrain
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    mK3 (Cell line)Kidney
    mK4 (Cell line)Kidney
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)

    See PDGFA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDGFA

    SOURCE GeneReport for Unigene cluster: Hs.535898
        SABiosciences Expression via Pathway-Focused PCR Arrays including PDGFA (see all 10): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Wound Healing in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PDGFA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PDGFA gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PDGFA1 platelet-derived growth factor alpha polypeptide 77.32(n)
    79.9(a)    		   374196  NM_204306.1  NP_989637.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDGFA6
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343385.1(540924-548964)
    African clawed frog
    (Xenopus laevis)    		 Amphibia PDGFA2 platelet-derived growth factor A chain, long form 77.46(n)    M23238.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pdgfa2 platelet-derived growth factor alpha polypeptide 79.75(n)   378480  AF200950.1 


    ENSEMBL Gene Tree for PDGFA (if available)
    TreeFam Gene Tree for PDGFA (if available) 

    Paralogs
    for PDGFA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDGFA gene
    PDGFB2  
    1 SIMAP similar gene for PDGFA using alignment to 5 protein entries:     PDGFA_HUMAN (see all proteins):
    PDGFB

    PDGFA for paralogs           About GeneDecksing



    Genomic Variants
    for PDGFA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/509 NCBI SNPs in PDGFA are shown (see all 509)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs127200311,2
    		C,F,--536416(+) CCTTCG/ATAAGA 2 -- ds50014Minor allele frequency- A:0.50NA WA CSA 8
    rs127200321,2
    		C,F,--536424(+) AGAACC/ATTCCA 2 -- ds50014Minor allele frequency- A:0.50NA WA CSA 8
    rs789756231,2
    		C,--536461(+) CGGCCA/GCCAGT 2 -- ds50010--------
    rs1399955271,2
    		--536488(+) AAGAAC/TGCGGG 2 -- ds50010--------
    rs1857028421,2
    		--536565(+) GGCAGG/TGTATG 2 -- ds50010--------
    rs96918321,2
    		C,--536598(+) CCAAGT/ACAGGT 2 -- ds50018Minor allele frequency- A:0.08NA WA CSA 13
    rs1904309291,2
    		--536632(+) CTTCAC/TGGTCT 2 -- ds50010--------
    rs1402272581,2
    		--536700(+) CCTCGC/GCCTAA 2 -- ds50010--------
    rs1439696751,2
    		--536726(+) AAGTCC/TGAGGT 2 -- ds50010--------
    rs1449587761,2
    		--536727(+) AGTCCC/GAGGTA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PDGFA (536895 - 559933 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PDGFA: --

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    Disorders / Diseases
    for PDGFA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDGFA for disorders           About GeneDecksing

    OMIM gene information: 173430    OMIM disorders: --

    20/95 diseases for PDGFA (see all 95):    About MalaCards
    denys-drash syndrome    desmoplastic small round cell tumor    central nervous system lymphoma    ureteral obstruction
    diffuse mesangial sclerosis    mesangial sclerosis    pre-eclampsia    pilocytic astrocytoma
    retinal detachment    myxoid liposarcoma    uterine fibroid    gastrointestinal stromal tumor
    squamous cell carcinoma    malignant mesothelioma    cavernous malformation    renovascular hypertension
    pulmonary fibrosis    essential thrombocythemia    idiopathic pulmonary fibrosis    liver cirrhosis

    10/62 Novoseek disease relationships for PDGFA gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 48.6 1 11322447 (1)
    denys-drash syndrome 44 1 10586431 (1)
    astrocytoma 43 3 7829210 (1), 11322447 (1)
    medulloblastoma 39.6 2 8841077 (1), 11544480 (1)
    atherosclerosis 38.3 4 11838000 (1), 18573494 (1), 15517943 (1), 9888867 (1)
    tumors 34.8 61 15389255 (6), 8619189 (3), 7923179 (3), 19628565 (2) (see all 33)
    atherosclerotic plaque 34.8 2 8653829 (1), 7914837 (1)
    oligodendroglioma 33.7 2 9482185 (1), 11322447 (1)
    osteosarcoma 27.3 2 2156959 (1), 2016070 (1)
    glioma 26.9 9 19707201 (5), 9402177 (1), 2016070 (1), 9049853 (1)

    Genetic Association Database (GAD): PDGFA
    Human Genome Epidemiology (HuGE) Navigator: PDGFA (3 documents)

    Export disorders for PDGFA gene to outside databases

    Publications
    for PDGFA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDGFA gene, integrated from 9 sources (see all 406):
    (articles sorted by number of sources associating them with PDGFA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PubMed id 1612586)1, 2, 9 Bonthron D.... Speleman F. (1992)
    2. DNA sequence variants of the platelet-derived growth factor A-chain gene. (PubMed id 11678848)1, 4, 9 Baron R....Drazen J.M. (2001)
    3. The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PubMed id 1505216)1, 3, 9 Stenman G....Betsholtz C. (1992)
    4. Structures of a platelet-derived growth factor/propep tide complex and a platelet-derived growth factor/receptor complex. (PubMed id 20534510)1, 2 Shim A.H....He X. (2010)
    5. High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. (PubMed id 10358027)1, 2 Goretzki L.... Stallcup W.B. (1999)
    6. Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene. (PubMed id 8486521)1, 2 Takimoto Y.... Deuel T.F. (1993)
    7. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (PubMed id 1317862)1, 2 Andersson M.... Heldin C.-H. (1992)
    8. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. (PubMed id 2536956)1, 3 Matsui T.... Aaronson S. (1989)
    9. Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. (PubMed id 2832727)1, 2 Rorsman F.... Betsholtz C. (1988)
    10. Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. (PubMed id 3422746)1, 2 Bonthron D.T.... Collins T. (1988)

    External Searches for PDGFA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDGFA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5154 HGNC: 8799 AceView: PDGFA Ensembl:ENSG00000197461 euGenes: HUgn5154
    ECgene: PDGFA Kegg: 5154 H-InvDB: PDGFA

    Other Databases showing PDGFA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDGFA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDGFA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFA Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: PDGFhttp://www.rndsystems.com/molecule_detail.aspx?m=1967

    Intellectual Property
    for PDGFA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDGFA gene:
    Search GeneIP for patents involving PDGFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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