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Aliases for PDGFA Gene

Aliases for PDGFA Gene

  • Platelet-Derived Growth Factor Alpha Polypeptide 2 3 4
  • Platelet-Derived Growth Factor Alpha Chain 2 3
  • Platelet-Derived Growth Factor A Chain 3 4
  • PDGF Subunit A 3 4
  • PDGF A-Chain 2 3
  • PDGF1 3 4
  • PDGF-A 3
  • PDGF-1 4

External Ids for PDGFA Gene

Previous GeneCards Identifiers for PDGFA Gene

  • GC07U990063
  • GC07Mh00634
  • GC07M000503
  • GC07M000536
  • GC07M000455

Summaries for PDGFA Gene

Entrez Gene Summary for PDGFA Gene

  • This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

GeneCards Summary for PDGFA Gene

PDGFA (Platelet-Derived Growth Factor Alpha Polypeptide) is a Protein Coding gene. Diseases associated with PDGFA include wrinkles and denys-drash syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is PDGFB.

UniProtKB/Swiss-Prot for PDGFA Gene

  • Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

Tocris Summary for PDGFA Gene

  • Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.

Gene Wiki entry for PDGFA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDGFA Gene

Genomics for PDGFA Gene

Regulatory Elements for PDGFA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDGFA Gene

Chromosome:
7
Start:
497,258 bp from pter
End:
520,668 bp from pter
Size:
23,411 bases
Orientation:
Minus strand

Genomic View for PDGFA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDGFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDGFA Gene

Proteins for PDGFA Gene

  • Protein details for PDGFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04085-PDGFA_HUMAN
    Recommended name:
    Platelet-derived growth factor subunit A
    Protein Accession:
    P04085
    Secondary Accessions:
    • B5BU73

    Protein attributes for PDGFA Gene

    Size:
    211 amino acids
    Molecular mass:
    24043 Da
    Quaternary structure:
    • Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.

    Three dimensional structures from OCA and Proteopedia for PDGFA Gene

    Alternative splice isoforms for PDGFA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDGFA Gene

Proteomics data for PDGFA Gene at MOPED

Post-translational modifications for PDGFA Gene

  • Glycosylation at Asn 134
  • Modification sites at PhosphoSitePlus

Other Protein References for PDGFA Gene

Antibody Products

No data available for DME Specific Peptides for PDGFA Gene

Domains & Families for PDGFA Gene

Graphical View of Domain Structure for InterPro Entry

P04085

UniProtKB/Swiss-Prot:

PDGFA_HUMAN :
  • The long form contains a basic insert which acts as a cell retention signal
  • Belongs to the PDGF/VEGF growth factor family.
Domain:
  • The long form contains a basic insert which acts as a cell retention signal
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with PDGFA: view

No data available for Gene Families for PDGFA Gene

Function for PDGFA Gene

Molecular function for PDGFA Gene

GENATLAS Biochemistry:
platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also involved in transformation process
UniProtKB/Swiss-Prot Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

Gene Ontology (GO) - Molecular Function for PDGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005161 platelet-derived growth factor receptor binding IPI 2536956
GO:0005515 protein binding IPI 7679113
GO:0005518 collagen binding IDA 8900172
GO:0008083 growth factor activity IDA 12070119
GO:0042803 protein homodimerization activity IDA 2836953
genes like me logo Genes that share ontologies with PDGFA: view
genes like me logo Genes that share phenotypes with PDGFA: view

Animal Models for PDGFA Gene

MGI Knock Outs for PDGFA:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDGFA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PDGFA Gene

Localization for PDGFA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDGFA Gene

Secreted. Note=Released by platelets upon wounding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDGFA Gene COMPARTMENTS Subcellular localization image for PDGFA gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
cytoskeleton 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 3754619
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005902 microvillus ISS --
genes like me logo Genes that share ontologies with PDGFA: view

Pathways & Interactions for PDGFA Gene

SuperPathways for PDGFA Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K/AKT Signaling in Cancer
4 GPCR Pathway
5 ERK Signaling
genes like me logo Genes that share pathways with PDGFA: view

PCR Array Products

SIGNOR curated interactions for PDGFA Gene

Activates:

Gene Ontology (GO) - Biological Process for PDGFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001525 angiogenesis ISS --
GO:0001775 cell activation TAS 10508235
GO:0001942 hair follicle development ISS --
genes like me logo Genes that share ontologies with PDGFA: view

Drugs & Compounds for PDGFA Gene

(14) Drugs for PDGFA Gene - From: NovoSeek, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 472
Dexamethasone Approved, Investigational Pharma Agonist 1806
Heparin Approved, Investigational Pharma Antagonist 672,226
Losartan Approved Pharma Antagonist 265
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473

(21) Additional Compounds for PDGFA Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AC 710
1351522-04-7
DMPQ dihydrochloride
1123491-15-5
SU 16f
251356-45-3
SU 6668
252916-29-3
Toceranib
356068-94-5
genes like me logo Genes that share compounds with PDGFA: view

Transcripts for PDGFA Gene

Unigene Clusters for PDGFA Gene

Platelet-derived growth factor alpha polypeptide:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDGFA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDGFA Gene

No ASD Table

Relevant External Links for PDGFA Gene

GeneLoc Exon Structure for
PDGFA
ECgene alternative splicing isoforms for
PDGFA

Expression for PDGFA Gene

mRNA expression in normal human tissues for PDGFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDGFA Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for PDGFA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.2) and Islet of Langerhans (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDGFA Gene



SOURCE GeneReport for Unigene cluster for PDGFA Gene Hs.535898

genes like me logo Genes that share expression patterns with PDGFA: view

Protein tissue co-expression partners for PDGFA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PDGFA Gene

Orthologs for PDGFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDGFA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDGFA 35
  • 86.7 (n)
  • 86.7 (a)
PDGFA 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDGFA 35
  • 88.95 (n)
  • 89.8 (a)
PDGFA 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdgfa 35
  • 87.76 (n)
  • 92.35 (a)
Pdgfa 16
Pdgfa 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDGFA 35
  • 97.14 (n)
  • 96.55 (a)
PDGFA 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdgfa 35
  • 87.59 (n)
  • 91.33 (a)
oppossum
(Monodelphis domestica)
Mammalia PDGFA 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDGFA 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDGFA 35
  • 77.32 (n)
  • 79.9 (a)
PDGF-A 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDGFA 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfa 35
  • 73.9 (n)
  • 76 (a)
Str.20307 35
African clawed frog
(Xenopus laevis)
Amphibia PDGFA 35
zebrafish
(Danio rerio)
Actinopterygii pdgfa 35
pdgfaa 35
  • 64.76 (n)
  • 65.14 (a)
pdgfaa 36
  • 59 (a)
OneToMany
pdgfab 36
  • 50 (a)
OneToMany
Species with no ortholog for PDGFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDGFA Gene

ENSEMBL:
Gene Tree for PDGFA (if available)
TreeFam:
Gene Tree for PDGFA (if available)

Paralogs for PDGFA Gene

Paralogs for PDGFA Gene

(1) SIMAP similar genes for PDGFA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PDGFA: view

Variants for PDGFA Gene

Sequence variations from dbSNP and Humsavar for PDGFA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1129401 -- 512,409(+) GTGGC(A/G)TGGAC synonymous-codon, reference
rs1129403 -- 497,345(+) TATTA(A/G)GTAAA utr-variant-3-prime
rs1129404 -- 497,301(+) CAAAA(A/G)AAGAA utr-variant-3-prime
rs1800814 -- 501,104(-) GGCTG(C/T)CTTCG intron-variant
rs1800815 -- 511,022(-) GTCCC(C/T)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDGFA Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
esv2733620 CNV Deletion 23290073

Variation tolerance for PDGFA Gene

Residual Variation Intolerance Score: 62.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDGFA Gene

HapMap Linkage Disequilibrium report
PDGFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDGFA Gene

Disorders for PDGFA Gene

MalaCards: The human disease database

(10) MalaCards diseases for PDGFA Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
wrinkles
denys-drash syndrome
  • drash syndrome
clear cell adenofibroma
  • cystadenofibroma
diffuse mesangial sclerosis
  • diffuse isolated mesangial sclerosis
frasier syndrome
  • fs
- elite association
Search PDGFA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDGFA

Genetic Association Database (GAD)
PDGFA
Human Genome Epidemiology (HuGE) Navigator
PDGFA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDGFA
genes like me logo Genes that share disorders with PDGFA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDGFA Gene

Publications for PDGFA Gene

  1. The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PMID: 1505216) Stenman G. … Betsholtz C. (Cytogenet. Cell Genet. 1992) 2 23 67
  2. FGF-2, TGFbeta-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. (PMID: 20379686) Miguita L. … de AraA_jo V.C. (J Appl Oral Sci 2010) 23 67
  3. Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain. (PMID: 19861972) Smirkin A. … Tanaka J. (J. Cereb. Blood Flow Metab. 2010) 23 67
  4. Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. (PMID: 20190664) Sun H.I. … Kilic T. (Neurosurgery 2010) 23 67
  5. [Expression and clinical significance of platelet-derived growth factor A in placenta of pre-eclampsia.]. (PMID: 20079029) Zhang A.C. … Zhou J.W. (Zhonghua Fu Chan Ke Za Zhi 2009) 23 67

Products for PDGFA Gene

Sources for PDGFA Gene

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