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PDGFA Gene

protein-coding   GIFtS: 63
GCID: GC07M000536

Platelet-Derived Growth Factor Alpha Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet-Derived Growth Factor Alpha Polypeptide1 2 3     PDGF12 3
PDGF A-Chain1 2     PDGF Subunit A2 3
Platelet-Derived Growth Factor Alpha Chain1 2     PDGF-A2
Platelet-Derived Growth Factor A Chain2 3     Platelet-Derived Growth Factor Alpha Isoform 2 Preproprotein2
PDGF-12 3     Platelet-Derived Growth Factor Subunit A2

External Ids:    HGNC: 87991   Entrez Gene: 51542   Ensembl: ENSG000001974617   OMIM: 1734305   UniProtKB: P040853   

Export aliases for PDGFA gene to outside databases

Previous GC identifers: GC07U990063 GC07Mh00634 GC07M000503 GC07M000455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDGFA Gene:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of
this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight
cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth
factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have
shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis;
knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDGFA Gene:
PDGFA (platelet-derived growth factor alpha polypeptide) is a protein-coding gene. Diseases associated with PDGFA include diffuse mesangial sclerosis, and wrinkles. GO annotations related to this gene include growth factor activity and protein homodimerization activity. An important paralog of this gene is PDGFB.

UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell
proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required
for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract,
normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and
normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is
modulated by the formation of heterodimers with PDGFB (By similarity)

summary for PDGFA Gene:
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine
kinase activity. They have roles in the regulation of many biological processes including embryonic
development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of
some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta,
which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce
receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates
the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma
pathways.

Gene Wiki entry for PDGFA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDGFA gene promoter:
         Sp1   AP-1   ATF-2   STAT5A   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PDGFA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDGFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

PDGFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDGFA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M000536:  view genomic region     (about GC identifiers)

Start:
536,895 bp from pter      End:
559,933 bp from pter
Size:
23,039 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 598,080-651,496     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085 (See protein sequence)
Recommended Name: Platelet-derived growth factor subunit A precursor  
Size: 211 amino acids; 24043 Da
Subunit: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked
dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by
PDGFRA and PDGFRB. Interacts with CSPG4
1 PDB 3D structure from and Proteopedia for PDGFA:
3MJK (3D)    
Secondary accessions: B5BU73
Alternative splicing: 2 isoforms:  P04085-1   P04085-2   

Explore the universe of human proteins at neXtProt for PDGFA: NX_P04085

Explore proteomics data for PDGFA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn134

  • See PDGFA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002598.4  NP_148983.1  

    ENSEMBL proteins: 
     ENSP00000383889   ENSP00000346508   ENSP00000383572   ENSP00000384673  
    Reactome Protein details: P04085

    PDGFA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PDGFA Protein
    R&D Systems Recombinant & Natural Proteins for PDGFA (PDGF-AA, PDGF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PDGFA
    OriGene Protein Over-expression Lysate for PDGFA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PDGFA
    GenScript Custom Purified and Recombinant Proteins Services for PDGFA
    Novus Biologicals PDGFA Proteins
    Novus Biologicals PDGFA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PDGFA
    Cloud-Clone Corp. Proteins for PDGFA

    PDGFA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDGFA
    R&D Systems Antibodies for PDGFA (PDGF-AA, PDGF-A, PDGF)
    OriGene Antibodies for PDGFA
    OriGene Custom Antibody Services for PDGFA
    Novus Biologicals PDGFA Antibodies
    Abcam antibodies for PDGFA
    Cloud-Clone Corp. Antibodies for PDGFA
    ThermoFisher Antibody for PDGFA
    LSBio Antibodies in human, mouse, rat for PDGFA

    PDGFA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDGFA
    R&D Systems ELISAs for PDGFA (PDGF-AA)         (see all)
    GenScript Custom Assay Services for PDGFA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDGFA
    Cloud-Clone Corp. CLIAs for PDGFA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR000072 PDGF/VEGF_dom
     IPR006782 PDGF_N

    Graphical View of Domain Structure for InterPro Entry P04085

    ProtoNet protein and cluster: P04085

    3 Blocks protein domains:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006782 Platelet-derived growth factor


    UniProtKB/Swiss-Prot: PDGFA_HUMAN, P04085
    Domain: The long form contains a basic insert which acts as a cell retention signal
    Similarity: Belongs to the PDGF/VEGF growth factor family


    PDGFA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDGFA_HUMAN, P04085
    Function: Growth factor that plays an essential role in the regulation of embryonic development, cell
    proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required
    for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract,
    normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and
    normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is
    modulated by the formation of heterodimers with PDGFB (By similarity)

         Genatlas biochemistry entry for PDGFA:
    platelet-derived growth factor,alpha polypeptide,24kDa,potent mitogen for cells of mesenchymal origin,also
    involved in transformation process

         Summary: 
    During embryonic development, PDGFA as signaling molecule affects the following cells:       fully expand
    Neural Tube: Oligodendrocyte Precursor Cells (Medial Ganglionic Eminence), Oligodendrocyte Precursor Cells (Lateral Ganglionic Eminence)      fully expand to see all 5 cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005161platelet-derived growth factor receptor binding IPI2536956
    GO:0005515protein binding IPI7679113
    GO:0005518collagen binding IDA8900172
    GO:0008083growth factor activity IDA12070119
    GO:0042803protein homodimerization activity IDA2836953
         
    PDGFA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDGFA:
     Increased cell number in G2M,  

         14 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pdgfa):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  muscle  nervous system 
     renal/urinary system  reproductive system  respiratory system  skeleton 

    PDGFA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdgfatm1Cbet for PDGFA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDGFA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDGFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDGFA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDGFA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDGFA:
    hsa-let-7d-5p (MIRT005549)

    Block miRNA regulation of human, mouse, rat PDGFA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDGFA (see all 38):
    hsa-miR-411* hsa-miR-379* hsa-miR-4328 hsa-miR-374c hsa-miR-3150b-3p hsa-miR-186 hsa-miR-34b hsa-miR-23a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDGFA
    Predesigned siRNA for gene silencing in human, mouse, rat PDGFA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDGFA

    Clone
    Products:
         
    OriGene clones in human, mouse for PDGFA (see all 9)
    OriGene ORF clones in mouse, rat for PDGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDGFA (NM_002607)
    Sino Biological Human cDNA Clone for PDGFA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDGFA
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDGFA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDGFA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDGFA_HUMAN, P04085: Secreted. Note=Released by platelets upon wounding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    golgi apparatus4
    nucleus2
    cytosol1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA3754619
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005902microvillus ISS--

    PDGFA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDGFA About   (see all 45)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Cytoskeleton remodeling Role of PDGFs in cell migration
    Cytoskeleton remodeling Role of PDGFs in cell migration
    PDGF Pathway0.00
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    5PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDGFA (see all 59)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    3 GeneGo (Thomson Reuters) Pathways for PDGFA
        Development PDGF signaling via STATs and NF-kB
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development PDGF signaling via MAPK cascades

    Selected BioSystems Pathways for PDGFA (see all 6)
        Focal Adhesion
    Cytokines and Inflammatory Response
    Regulation of Actin Cytoskeleton
    Integrated Pancreatic Cancer Pathway
    PDGF Pathway


    2 Reactome Pathways for PDGFA
        Signaling by PDGF
    Non-integrin membrane-ECM interactions


    Selected Kegg Pathways  (Kegg details for PDGFA) (see all 15):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway


    PDGFA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDGFA (see all 10): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Wound Healing in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PDGFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for PDGFA (P040853 ENSP000003465084) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPARCP094863, ENSP000002310614I2D: score=3 STRING: ENSP00000231061
    FURINP099583, ENSP000002681714I2D: score=2 STRING: ENSP00000268171
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    PDGFBP011273, ENSP000003303824I2D: score=1 STRING: ENSP00000330382
    PDGFRAP162343, ENSP000002572904I2D: score=3 STRING: ENSP00000257290
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 53):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0001666response to hypoxia IEA--
    GO:0001775cell activation TAS10508235
    GO:0001942hair follicle development ISS--
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--

    PDGFA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PDGFA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 6668 PDGFR, VEGFR and FGFR inhibitor [252916-29-3]
    Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
    DMPQ dihydrochloride Potent, selective inhibitor of PDGFRbeta [137206-97-4]
    SU 16fPotent and selective PDGFRbeta inhibitor[251356-45-3]

    Selected Novoseek inferred chemical compound relationships for PDGFA gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 49.9 10 12153981 (1), 1651380 (1), 8697155 (1), 9482185 (1) (see all 8)
    vegf 46.7 34 18592007 (4), 9486038 (3), 15334938 (3), 16103054 (3) (see all 21)
    lysophosphatidylcholine 42.2 3 10865829 (1), 10588364 (1), 7641323 (1)
    tgf beta1 34.5 5 15682418 (3), 15498125 (1), 19706334 (1)
    tyrosine 29.6 4 15061151 (1), 16689459 (1), 18084259 (1), 12651221 (1)
    pd 98,059 28.8 1 10446131 (1)
    cycloheximide 26.1 2 8427857 (1), 1694856 (1)
    cystine 25.4 1 8179329 (1)
    procollagen 22.8 1 7806036 (1)
    oligonucleotide 17.5 2 11823426 (1), 8780387 (1)



    PDGFA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PDGFA gene (2 alternative transcripts): 
    NM_002607.5  NM_033023.4  

    Unigene Cluster for PDGFA:

    Platelet-derived growth factor alpha polypeptide
    Hs.535898  [show with all ESTs]
    Unigene Representative Sequence: NM_002607
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402802(uc003sir.3 uc003sis.3) ENST00000354513 ENST00000400761
    ENST00000482462(uc003sit.1) ENST00000405692 ENST00000426681
    miRNA
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    Block miRNA regulation of human, mouse, rat PDGFA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDGFA (see all 38):
    hsa-miR-411* hsa-miR-379* hsa-miR-4328 hsa-miR-374c hsa-miR-3150b-3p hsa-miR-186 hsa-miR-34b hsa-miR-23a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDGFA
    Clone
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    OriGene ORF clones in mouse, rat for PDGFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PDGFA (NM_002607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDGFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDGFA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDGFA
    OriGene qSTAR qPCR primer pairs in human, mouse for PDGFA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDGFA
      QuantiTect SYBR Green Assays in human, mouse, rat PDGFA
      QuantiFast Probe-based Assays in human, mouse, rat PDGFA

    Additional mRNA sequence: 

    AB451309.1 AB451439.1 AK292217.1 BC109246.1 X03795.1 X06374.1 

    3 DOTS entries:

    DT.95265064  DT.87077343  DT.95069591 

    Selected AceView cDNA sequences (see all 25):

    BM702563 AA403247 AI276565 BM142229 CK820161 H89357 H89543 BM693414 
    AW118697 BQ001096 BQ002008 AV729452 AI633869 AA770172 AI934350 BE503326 
    AI625002 AI651133 BQ366054 NM_033023 BF094250 X06374 NM_002607 BM787770 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PDGFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATACCTAC
    PDGFA Expression
    About this image


    PDGFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             mK3
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Conjunctival Epithelium
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 4 entries
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 3 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 3 entries
             Zygote Zygote
    PDGFA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDGFA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535898
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PDGFA (see all 10): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              Wound Healing in human mouse rat
              Angiogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PDGFA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdgfa1 , 5 platelet derived growth factor, alpha1, 5 87.76(n)1
    92.35(a)1
      5 (77.65 cM)5
    185901  NM_008808.31  NP_032834.11 
     1389760145 
    chicken
    (Gallus gallus)
    Aves PDGFA1 platelet-derived growth factor alpha polypeptide 77.32(n)
    79.9(a)
      374196  NM_204306.1  NP_989637.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDGFA6
    platelet-derived growth factor alpha polypeptide
    62(a)
    1 ↔ 1
    GL343385.1(540924-555309)
    African clawed frog
    (Xenopus laevis)
    Amphibia PDGFA2 platelet-derived growth factor A chain, long form 77.46(n)    M23238.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdgfa2 platelet-derived growth factor alpha polypeptide 79.75(n)   378480  AF200950.1 


    ENSEMBL Gene Tree for PDGFA (if available)
    TreeFam Gene Tree for PDGFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDGFA gene
    PDGFB2  
    1 SIMAP similar gene for PDGFA using alignment to 4 protein entries:     PDGFA_HUMAN (see all proteins):
    PDGFB

    PDGFA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDGFA (see all 625)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127200311,2
    C,F--536416(+) CCTTCG/ATAAGA 2 -- ds50014Minor allele frequency- A:0.50NA WA CSA 8
    rs127200321,2
    C,F--536424(+) AGAACC/ATTCCA 2 -- ds50014Minor allele frequency- A:0.50NA WA CSA 8
    rs789756231,2
    C--536461(+) CGGCCA/GCCAGT 2 -- ds50010--------
    rs1399955271,2
    --536488(+) AAGAAC/TGCGGG 2 -- ds50010--------
    rs1857028421,2
    --536565(+) GGCAGG/TGTATG 2 -- ds50010--------
    rs96918321,2
    C--536598(+) CCAAGT/ACAGGT 2 -- ds50018Minor allele frequency- A:0.08NA WA CSA 13
    rs1904309291,2
    --536632(+) CTTCAC/TGGTCT 2 -- ds50010--------
    rs1402272581,2
    --536700(+) CCTCGC/GCCTAA 2 -- ds50010--------
    rs1439696751,2
    C--536726(+) AAGTCC/TGAGGT 2 -- ds50010--------
    rs1449587761,2
    C--536727(+) AGTCCC/GAGGTA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PDGFA (536895 - 559933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PDGFA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733620CNV Deletion23290073
    nsv887128CNV Loss21882294
    dgv7078n71CNV Loss21882294
    dgv7074n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173430    OMIM disorders: --

    Selected diseases for PDGFA (see all 98):    
    About MalaCards
    diffuse mesangial sclerosis    wrinkles    denys-drash syndrome    tendinitis
    ureteral obstruction    bone fracture    retinal detachment    renovascular hypertension
    desmoplastic small round cell tumor    myxoid liposarcoma    renal dysplasia    relapsing-remitting multiple sclerosis
    pulmonary fibrosis    pleomorphic adenoma    central nervous system lymphoma    pilocytic astrocytoma
    ependymoma    oligodendroglioma    arteriosclerosis    uterine fibroid


    PDGFA for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PDGFA gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 48.6 1 11322447 (1)
    denys-drash syndrome 44 1 10586431 (1)
    astrocytoma 43 3 7829210 (1), 11322447 (1)
    medulloblastoma 39.6 2 8841077 (1), 11544480 (1)
    atherosclerosis 38.3 4 11838000 (1), 18573494 (1), 15517943 (1), 9888867 (1)
    tumors 34.8 61 15389255 (6), 8619189 (3), 7923179 (3), 19628565 (2) (see all 33)
    atherosclerotic plaque 34.8 2 8653829 (1), 7914837 (1)
    oligodendroglioma 33.7 2 9482185 (1), 11322447 (1)
    osteosarcoma 27.3 2 2156959 (1), 2016070 (1)
    glioma 26.9 9 19707201 (5), 9402177 (1), 2016070 (1), 9049853 (1)

    Genetic Association Database (GAD): PDGFA
    Human Genome Epidemiology (HuGE) Navigator: PDGFA (3 documents)

    Export disorders for PDGFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDGFA gene, integrated from 10 sources (see all 411):
    (articles sorted by number of sources associating them with PDGFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. (PubMed id 1612586)1, 2, 9 Bonthron D.... Speleman F. (Genomics 1992)
    2. DNA sequence variants of the platelet-derived growth factor A-chain gene. (PubMed id 11678848)1, 4, 9 Baron R....Drazen J.M. (Clin. Exp. Allergy 2001)
    3. The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (PubMed id 1505216)1, 3, 9 Stenman G....Betsholtz C. (Cytogenet. Cell Genet. 1992)
    4. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    5. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. (PubMed id 20534510)1, 2 Shim A.H.... He X. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    6. High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. (PubMed id 10358027)1, 2 Goretzki L.... Stallcup W.B. (J. Biol. Chem. 1999)
    7. Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene. (PubMed id 8486521)1, 2 Takimoto Y.... Deuel T.F. (Hiroshima J. Med. Sci. 1993)
    8. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. (PubMed id 1317862)1, 2 Andersson M.... Heldin C.-H. (J. Biol. Chem. 1992)
    9. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. (PubMed id 2536956)1, 3 Matsui T.... Aaronson S. (Science 1989)
    10. Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. (PubMed id 2832727)1, 2 Rorsman F.... Betsholtz C. (Mol. Cell. Biol. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5154 HGNC: 8799 AceView: PDGFA Ensembl:ENSG00000197461 euGenes: HUgn5154
    ECgene: PDGFA Kegg: 5154 H-InvDB: PDGFA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDGFA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDGFA Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: PDGFhttp://www.rndsystems.com/molecule_detail.aspx?m=1967

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDGFA gene:
    Search GeneIP for patents involving PDGFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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