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Aliases for PDE9A Gene

Aliases for PDE9A Gene

  • Phosphodiesterase 9A 2 3
  • HSPDE9A2 3 6
  • High Affinity CGMP-Specific 3,5-Cyclic Phosphodiesterase 9A 3
  • CGMP-Specific 3,5-Cyclic Phosphodiesterase Type 9 3
  • Phosphodiesterase PDE9A21 3
  • EC 3.1.4.35 4

External Ids for PDE9A Gene

Summaries for PDE9A Gene

Entrez Gene Summary for PDE9A Gene

  • The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDE9A Gene

PDE9A (Phosphodiesterase 9A) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-GMP phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE9A Gene

  • Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

Gene Wiki entry for PDE9A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE9A Gene

Genomics for PDE9A Gene

Genomic Location for PDE9A Gene

Start:
42,653,636 bp from pter
End:
42,775,509 bp from pter
Size:
121,874 bases
Orientation:
Plus strand

Genomic View for PDE9A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE9A Gene

Regulatory Elements for PDE9A Gene

Proteins for PDE9A Gene

  • Protein details for PDE9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76083-PDE9A_HUMAN
    Recommended name:
    High affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A
    Protein Accession:
    O76083
    Secondary Accessions:
    • B2RBI5
    • B4DFI5
    • D3DSJ8
    • D3DSJ9
    • O75490
    • O75491
    • O95225
    • Q53Y40
    • Q5QD39
    • Q86SF7
    • Q86SI6
    • Q86SJ3
    • Q86WN3
    • Q86WN4
    • Q86WN5
    • Q86WN6
    • Q86WN7
    • Q86WN8
    • Q86WN9
    • Q86WP0

    Protein attributes for PDE9A Gene

    Size:
    593 amino acids
    Molecular mass:
    68493 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDE9A Gene

neXtProt entry for PDE9A Gene

Proteomics data for PDE9A Gene at MOPED

Post-translational modifications for PDE9A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PDE9A Gene

Domains for PDE9A Gene

Gene Families for PDE9A Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE9A Gene

UniProtKB/Swiss-Prot:

PDE9A_HUMAN
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain:
    • O76083
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.:
    • O76083
genes like me logo Genes that share domains with PDE9A: view

Function for PDE9A Gene

Molecular function for PDE9A Gene

GENATLAS Biochemistry: cGMP phosphodiesterase 9A,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by zaprinast
UniProtKB/Swiss-Prot Function: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

Enzyme Numbers (IUBMB) for PDE9A Gene

Gene Ontology (GO) - Molecular Function for PDE9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity TAS 9856478
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity IEA --
genes like me logo Genes that share ontologies with PDE9A: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PDE9A Gene

Localization for PDE9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE9A Gene

Isoform PDE9A1: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum.
Isoform PDE9A2: Cell projection, ruffle membrane. Cytoplasm, perinuclear region.
Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum.
Isoform PDE9A17: Cytoplasm. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE9A Gene COMPARTMENTS Subcellular localization image for PDE9A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDE9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane --
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with PDE9A: view

Pathways for PDE9A Gene

genes like me logo Genes that share pathways with PDE9A: view

Pathways by source for PDE9A Gene

1 KEGG pathway for PDE9A Gene

Gene Ontology (GO) - Biological Process for PDE9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9856478
GO:0007596 blood coagulation TAS --
GO:0008152 metabolic process TAS 9856478
GO:0019934 cGMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with PDE9A: view

Compounds for PDE9A Gene

(6) HMDB Compounds for PDE9A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Manganese
  • manganese
7439-96-5

(2) Drugbank Compounds for PDE9A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-ISOBUTYL-1-METHYLXANTHINE
target
Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine
target

(2) IUPHAR Ligand for PDE9A Gene

Ligand Type Action Affinity Pubmed IDs
SCH51866 Inhibitor Inhibition 7.2
zaprinast Inhibitor Inhibition 6.8

(2) Novoseek inferred chemical compound relationships for PDE9A Gene

Compound -log(P) Hits PubMed IDs
cgmp 64.7 6
ibmx 58.5 1
genes like me logo Genes that share compounds with PDE9A: view

Transcripts for PDE9A Gene

Unigene Clusters for PDE9A Gene

Phosphodiesterase 9A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE9A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - -
SP9: - - - - -
SP10: - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13:
SP14:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PDE9A Gene

GeneLoc Exon Structure for
PDE9A
ECgene alternative splicing isoforms for
PDE9A

Expression for PDE9A Gene

mRNA expression in normal human tissues for PDE9A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE9A Gene

This gene is overexpressed in Colon - Transverse (7.4), Colon - Sigmoid (5.2), and Small Intestine - Terminal Ileum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PDE9A Gene

SOURCE GeneReport for Unigene cluster for PDE9A Gene Hs.473927

mRNA Expression by UniProt/SwissProt for PDE9A Gene

O76083-PDE9A_HUMAN
Tissue specificity: Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
genes like me logo Genes that share expressions with PDE9A: view

Orthologs for PDE9A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDE9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE9A 36
  • 99.37 (n)
  • 99.62 (a)
PDE9A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE9A 36
  • 88.55 (n)
  • 91.32 (a)
PDE9A 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE9A 36
  • 88.95 (n)
  • 92.09 (a)
PDE9A 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde9a 36
  • 87.4 (n)
  • 93.19 (a)
Pde9a 16
Pde9a 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE9A 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE9A 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde9a 36
  • 86.87 (n)
  • 92.23 (a)
chicken
(Gallus gallus)
Aves PDE9A 36
  • 79.75 (n)
  • 88.39 (a)
PDE9A 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE9A 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493061 36
  • 66.74 (n)
  • 65.52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5739 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01044346.1 37
  • 71 (a)
OneToMany
Dr.20838 36
pde9a 36
  • 74.54 (n)
  • 77.95 (a)
pde9a 37
  • 77 (a)
OneToMany
PDE9A (3 of 4) 37
  • 42 (a)
OneToMany
PDE9A (4 of 4) 37
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pde9 37
  • 15 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDE2 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
CSA.6307 37
  • 40 (a)
OneToMany
Species with no ortholog for PDE9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE9A Gene

ENSEMBL:
Gene Tree for PDE9A (if available)
TreeFam:
Gene Tree for PDE9A (if available)

Paralogs for PDE9A Gene

Paralogs for PDE9A Gene

Selected SIMAP similar genes for PDE9A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDE9A: view

Variants for PDE9A Gene

Sequence variations from dbSNP and Humsavar for PDE9A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs228093 -- 42,656,150(-) TGGGG(C/T)GGATG intron-variant
rs374281 -- 42,676,563(-) TGATG(A/C)CAGTT intron-variant
rs729861 -- 42,756,452(+) CCCCC(A/G)CTTTT intron-variant
rs730933 -- 42,756,963(+) CTTTC(A/G)GGACT intron-variant
rs735093 -- 42,686,997(+) AAATG(G/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE9A Gene

Variant ID Type Subtype PubMed ID
nsv522001 CNV Gain 19592680
esv2666871 CNV Deletion 23128226
nsv913803 CNV Loss 21882294
nsv913804 CNV Loss 21882294
nsv3534 CNV Insertion 18451855
nsv913805 CNV Loss 21882294
nsv913806 CNV Loss 21882294
esv2723566 CNV Deletion 23290073
nsv913807 CNV Loss 21882294
nsv525775 CNV Loss 19592680
esv995110 CNV Deletion 20482838
nsv459276 CNV Gain 19166990
esv2723567 CNV Deletion 23290073
esv2675114 CNV Deletion 23128226
esv2723568 CNV Deletion 23290073
esv1010803 CNV Loss 20482838
esv2723569 CNV Deletion 23290073
esv2670844 CNV Deletion 23128226
nsv913808 CNV Loss 21882294
dgv4752n71 CNV Loss 21882294
nsv459277 CNV Loss 19166990
esv2723570 CNV Deletion 23290073
nsv913811 CNV Gain 21882294
esv1704509 CNV Insertion 17803354
esv2723571 CNV Deletion 23290073

Relevant External Links for PDE9A Gene

HapMap Linkage Disequilibrium report
PDE9A

Disorders for PDE9A Gene

Relevant External Links for PDE9A

Genetic Association Database (GAD)
PDE9A
Human Genome Epidemiology (HuGE) Navigator
PDE9A
genes like me logo Genes that share disorders with PDE9A: view

No data available for UniProtKB/Swiss-Prot for PDE9A Gene

Publications for PDE9A Gene

  1. Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. (PMID: 9624146) Fisher D.A. … Cheng J.B. (J. Biol. Chem. 1998) 2 3 4 23
  2. Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence. (PMID: 9856478) Guipponi M. … Antonarakis S.E. (Hum. Genet. 1998) 3 4 23
  3. Identification and characterization of a new human type 9 cGMP- specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants. (PMID: 14527714) Wang P. … Billah M.M. (Gene 2003) 3 4 23
  4. Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. (PMID: 17008408) Wong M.L. … Licinio J. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23 49
  5. Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene. (PMID: 17090334) Rentero C. … Puigdomenech P. (BMC Mol. Biol. 2006) 3 4 23

Products for PDE9A Gene

Sources for PDE9A Gene

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