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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDE9A Gene

protein-coding GIFtS: 62
GCID: GC21P044073

phosphodiesterase 9A

Explore 5 diseases affiliated with
PDE9A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Phosphodiesterase 9A¹ ²		High Affinity CGMP-Specific 3',5'-Cyclic Phosphodiesterase 9A²
HSPDE9A2² ⁵		Phosphodiesterase PDE9A21²
CGMP-Specific 3',5'-Cyclic Phosphodiesterase Type 9, EC 3.1.4.1711		EC 3.1.4.35³
CGMP-Specific 3',5'-Cyclic Phosphodiesterase Type 9²

External Ids:	HGNC: 8795¹	Entrez Gene: 5152²	Ensembl: ENSG00000160191⁷	OMIM: 602973⁵	UniProtKB: O76083³

Export aliases for PDE9A gene to outside databases

Previous GC identifers: GC21P040621 GC21P042968 GC21P042946 GC21P029521

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE9A:

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The

encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic

nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PDE9A_HUMAN, O76083

Function: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes

Gene Wiki entry for PDE9A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011515.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDE9A gene promoter:
STAT5B Spz1 STAT4 STAT6 STAT5A Evi-1 AREB6 CP2 STAT2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDE9A promoter sequence

Search SABiosciences Chromatin IP Primers for PDE9A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE9A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

PDE9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE9A gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P044073:	GeneLoc	Nature:405,311-319
Start:	44,073,746 bp from pter	29,621,249 bp from centromere
End:	44,195,619 bp from pter	29,742,945 bp from centromere
Size:	121,874 bases	121,697 bases
Orientation:	plus strand	plus strand

Whole chromosome sequencing:
cDNA sequence:	AF067223
genomic clones:	KB1559F8 to KB51A8

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDE9A_HUMAN, O76083 (See protein sequence)

Recommended Name: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Size: 593 amino acids; 68493 Da

Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a

preference for magnesium and/or manganese ions

Subcellular location: Isoform PDE9A1: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus.

Endoplasmic reticulum

Subcellular location: Isoform PDE9A2: Cell projection, ruffle membrane. Cytoplasm, perinuclear region

Subcellular location: Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum

Subcellular location: Isoform PDE9A17: Cytoplasm. Endoplasmic reticulum

6/15 PDB 3D structures from and Proteopedia for PDE9A (see all 15):

2HD1 (3D)

2YY2 (3D)

3DY8 (3D)

3DYL (3D)

3DYN (3D)

3DYQ (3D)

Secondary accessions: B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6

Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0

Alternative splicing: 16 isoforms: O76083-1 O76083-2 O76083-3 O76083-4 O76083-5 O76083-6 O76083-7 O76083-8

O76083-9 O76083-10 O76083-11 O76083-12 O76083-13 O76083-14 O76083-15 O76083-16

Explore the universe of human proteins at neXtProt for PDE9A: NX_O76083

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O76083

PDE9A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (20 alternative transcripts):

NP_001001567.1 NP_001001568.1 NP_001001569.1 NP_001001570.1 NP_001001571.1 NP_001001572.1 NP_001001573.1 NP_001001574.1

NP_001001575.1 NP_001001576.1 NP_001001577.1 NP_001001578.1 NP_001001579.1 NP_001001580.1 NP_001001581.1 NP_001001582.1

NP_001001583.1 NP_001001584.1 NP_001001585.1 NP_002597.1

ENSEMBL proteins:

ENSP00000335242 ENSP00000291539 ENSP00000369685 ENSP00000381287 ENSP00000381289

ENSP00000381291 ENSP00000328699 ENSP00000335365 ENSP00000381281 ENSP00000381285

ENSP00000381283 ENSP00000344730 ENSP00000381280 ENSP00000441899

Reactome Protein details: O76083
Human Recombinant Protein Products:

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	Uscn Proteins for PDE9A

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0032587	ruffle membrane	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

PDE9A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PDE9A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDE9A for domains About GeneDecksing

4 InterPro domains/families:

IPR002073 PDEase_catalytic_dom

IPR023174 PDEase_CS

IPR023088 PDEase

IPR003607 HD/PDEase_dom

Graphical View of Domain Structure for InterPro Entry O76083

ProtoNet protein and cluster: O76083

UniProtKB/Swiss-Prot: PDE9A_HUMAN, O76083

Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal

regulatory domain

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PDE9A_HUMAN, O76083

Function: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes

Catalytic activity: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

Enzyme regulation: Inhibited by zaprinast

Genatlas biochemistry entry for PDE9A:

cGMP phosphodiesterase 9A,involved in signal transduction

Enzyme Number (IUBMB): EC 3.1.4.35¹

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In Situ Assay
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	TAS	9856478
GO:0005515	protein binding	IPI	19060904
GO:0046872	metal ion binding	IEA	--
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IEA	--

PDE9A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Nitric oxide stimulates guanylate cyclase

	Nitric oxide stimulates guanylate cyclase	1.00			Platelet homeostasis	0.34
	cGMP effects	0.75

Regulation of Androgen receptor activity

Regulation of Androgen receptor activity

1.00

Purine metabolism

Purine metabolism

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for PDE9A

Regulation of Androgen receptor activity

4 Reactome Pathways for PDE9A

	Hemostasis
	cGMP effects
	Platelet homeostasis
	Nitric oxide stimulates guanylate cyclase

1 Kegg Pathway (Kegg details for PDE9A):

Purine metabolism

PDE9A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PDE9A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/46 Interacting proteins for PDE9A (O76083^{1, 2, 3} ENSP00000291539⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIM32	Q13049¹^,³, ENSP00000363095⁴	EBI-742764,EBI-742790 I2D: score=4 STRING: ENSP00000363095
PHYHIPL	Q96FC7²^,³, ENSP00000362987⁴	MINT-67385 I2D: score=5 STRING: ENSP00000362987
SHB	Q15464³	I2D: score=1
PDE9A	O76083²	MINT-68235
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007596	blood coagulation	TAS	--

PDE9A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PDE9A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PDE9A

6 HMDB Compounds for PDE9A About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Manganese	manganese	7439-96-5	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 DrugBank Compounds for PDE9A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3-ISOBUTYL-1-METHYLXANTHINE	--	--	target	--	10592235
Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine	--	--	target	--	--

2 Novoseek chemical compound relationships for PDE9A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cgmp	64.7	7	9624146 (3), 18564357 (2), 14527714 (1)
ibmx	58.5	1	9624146 (1)

Search CenterWatch for drugs/clinical trials and news about PDE9A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDE9A gene (20 alternative transcripts):

NM_001001567.1 NM_001001568.1 NM_001001569.1 NM_001001570.1 NM_001001571.1 NM_001001572.1 NM_001001573.1 NM_001001574.1

NM_001001575.1 NM_001001576.1 NM_001001577.1 NM_001001578.1 NM_001001579.1 NM_001001580.1 NM_001001581.1 NM_001001582.1

NM_001001583.1 NM_001001584.2 NM_001001585.1 NM_002606.2

Unigene Cluster for PDE9A:

Phosphodiesterase 9A

Hs.473927 [show with all ESTs]

Unigene Representative Sequence: AK127770

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000460905 ENST00000472401 ENST00000335512(uc002zbn.3 uc002zbq.3 uc002zbs.3 uc002zbr.3 uc002zbt.3 uc002zbu.3 uc002zbv.3 uc002zbw.3 uc002zbx.3 uc002zby.3 uc002zcc.3 uc002zcd.3)

ENST00000470987(uc002zbo.3 uc002zbz.3) ENST00000291539(uc002zbm.3 uc002zca.3 uc002zcb.3 uc002zce.3 uc002zcf.3)

ENST00000490803(uc002zbp.3) ENST00000486902 ENST00000380328 ENST00000495521

ENST00000398232 ENST00000462571(uc002zcg.3) ENST00000398234 ENST00000398236

ENST00000468805 ENST00000328862 ENST00000335440 ENST00000398225 ENST00000497805

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Additional cDNA sequence:

AF048837.1 AF067223.1 AF067224.1 AF067225.1 AF067226.1 AK001165.1 AK001307.1 AK096468.1

AK127770.1 AK294112.1 AK308753.1 AK314679.1 AY196299.1 AY196300.1 AY196301.1 AY196302.1

AY196303.1 AY196304.1 AY196305.1 AY196306.1 AY196307.1 AY196308.1 AY196309.1 AY196310.1

AY196311.1 AY196312.1 AY196313.1 AY196314.1 AY242121.1 AY701187.1 BC009047.1 BT007016.1

24/26 DOTS entries (see all 26):

DT.91736763 DT.211771 DT.100824007 DT.100663867 DT.100824009 DT.101980008 DT.100823998 DT.100823992

DT.100823997 DT.40309894 DT.95269406 DT.100823993 DT.100824002 DT.100824004 DT.100824006 DT.100035505

DT.100824008 DT.92030465 DT.40256993 DT.75133739 DT.40298721 DT.95269403 DT.100823994 DT.121140559

24/135 AceView cDNA sequences (see all 135):

CR599741 AA333991 NM_001001583 BX112138 NM_001001584 CD671364 NM_001001581 NM_001001576

BQ706711 NM_001001582 AK127770 NM_001001572 NM_001001569 AI658983 NM_002606 NM_001001574

NM_001001567 NM_001001580 NM_001001577 AA456038 NM_001001571 BX641267 NM_001001568 NM_001001575

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PDE9A (see all 14) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·
SP1:							-								-		-		-				-		-		-																-
SP2:							-						-		-		-		-				-		-		-																-
SP3:							-		-		-				-		-		-				-		-		-																-
SP4:							-		-		-				-		-		-				-		-		-						-										-
SP5:							-		-		-		-		-		-		-				-		-		-																-

ExUns:	19b	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25
SP1:									-
SP2:									-
SP3:									-
SP4:									-
SP5:									-

ECgene alternative splicing isoforms for PDE9A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDE9A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCTGTACA

About this image

PDE9A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Bone

Zeugopod Epiphyseal End

Bone

Eye

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

See PDE9A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE9A

SOURCE GeneReport for Unigene cluster: Hs.473927

UniProtKB/Swiss-Prot: PDE9A_HUMAN, O76083

Tissue specificity: Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung,

thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart,

kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PDE9A gene from 5/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PDE9A⁶	Uncharacterized protein	88(a)	1 ↔ 1	1(112945192-112987910)
lizard (Anolis carolinensis)	Reptilia	PDE9A⁶	--	81(a)	1 ↔ 1	3(137505653-137597944)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX733599.1²	--	73.75(n)		BX733599.1
zebrafish (Danio rerio)	Actinopterygii	Dr.20838²	Transcribed sequence with moderate similarity to protein more	76.96(n)		BG799803.1
fruit fly (Drosophila melanogaster)	Insecta	Pde9⁶	Phosphodiesterase 9	13(a)	1 ↔ 1	X(12679596-12790864)

ENSEMBL Gene Tree for PDE9A (if available)
TreeFam Gene Tree for PDE9A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PDE9A gene

PDE4D² PDE3A² PDE8B² PDE4B² PDE4C² PDE1B² PDE1A² PDE7B²

PDE1C² PDE7A² PDE8A² PDE4A² PDE3B²

7 SIMAP similar genes for PDE9A using alignment to 2 protein entries: PDE9A_HUMAN (see all proteins):

PDE4 PDE2A PDE8A PDE4C PDE4D PDE8B

PDE5A

PDE9A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80259735^1,2	C	--	44071890(+)	`CTGCTG/TAGGCC`	20	--	us2k¹		0	--	--	--	--
rs228038^1,2	C,F,A,H,	--	44071939(+)	`CCTAAA/GAGTGC`	20	--	us2k¹		30		MN NS EA NA WA CSA	4388
rs79862501^1,2	F,	--	44072026(+)	`CTGGAC/TGCACA`	20	--	us2k¹		1		WA	118
rs3831878^1,2	C,	--	44072057(+)	`CTCCA-/CCCTCC`	20	--	us2k¹		0	--	--	--	--
rs200690702^1,2		--	44072060(+)	`CACCC-/TCCTGG`	20	--	us2k¹		0	--	--	--	--
rs7282960^1,2	C,	--	44072089(+)	`CACCCC/GCCATG`	20	--	us2k¹		2		CSA WA	120
rs187578889^1,2		--	44072118(+)	`TGGGGC/TTCTTG`	20	--	us2k¹		0	--	--	--	--
rs228039^1,2	C,F,A,H,	--	44072193(+)	`GCCAAC/TGAGCC`	20	--	us2k¹ tfbs³		29		MN EA NS NA WA CSA	4033
rs148840407^1,2		--	44072276(+)	`AGCATC/TGGAAC`	20	--	us2k¹		0	--	--	--	--
rs148309932^1,2		--	44072319(+)	`GCTCA-/CTTCAA TGAGCCGGGGACAC`	20	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PDE9A (44073746 - 44195619 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDE9A: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PDE9A for disorders           About GeneDecksing

OMIM gene information: 602973    OMIM disorders: --

5 diseases for PDE9A:    About MalaCards

sickle cell anemia sickle cell disease anemia malaria

prostatitis

Human Genome Epidemiology (HuGE) Navigator: PDE9A (5 documents)

Export disorders for PDE9A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PDE9A gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with PDE9A)

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world of online information

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. (PubMed id 9624146)^{1, 2, 3, 9} Fisher D.A.... Cheng J.B. (1998)
Identification and characterization of a new human type 9 cGMP- specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants. (PubMed id 14527714)^{1, 2, 9} Wang P.... Billah M.M. (2003)
Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence. (PubMed id 9856478)^{1, 2, 9} Guipponi M.... Antonarakis S.E. (1998)
Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene. (PubMed id 17090334)^{1, 2, 9} Rentero C. and Puigdomenech P. (2006)
Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. (PubMed id 15210993)^{1, 2} Huai Q.... Ke H. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene. (PubMed id 12565835)^{1, 2} Rentero C.... Puigdomenech P. (2003)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. (PubMed id 17008408)^{1, 9} Wong M.L....Licinio J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5152	HGNC: 8795	AceView: PDE9A	Ensembl:ENSG00000160191	euGenes: HUgn5152
ECgene: PDE9A	Kegg: 5152	H-InvDB: PDE9A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PDE9A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PDE9A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PDE9A gene:
Search GeneIP for patents involving PDE9A

GeneCards and IP:
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