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Aliases for PDE8B Gene

Aliases for PDE8B Gene

  • Phosphodiesterase 8B 2 3
  • Cell Proliferation-Inducing Gene 22 Protein 3 4
  • HsPDE8B 3 4
  • PPNAD3 3 6
  • ADSD 3 6
  • High Affinity CAMP-Specific And IBMX-Insensitive 3,5-Cyclic Phosphodiesterase 8B 3
  • 3,5 Cyclic Nucleotide Phosphodiesterase 8B 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4

External Ids for PDE8B Gene

Previous GeneCards Identifiers for PDE8B Gene

  • GC05P075312
  • GC05P076741
  • GC05P076545
  • GC05P076590
  • GC05P076542
  • GC05P071714

Summaries for PDE8B Gene

Entrez Gene Summary for PDE8B Gene

  • The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for PDE8B Gene

PDE8B (Phosphodiesterase 8B) is a Protein Coding gene. Diseases associated with PDE8B include pigmented nodular adrenocortical disease, primary, 3 and striatal degeneration, autosomal dominant. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and phosphorelay response regulator activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE8B Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland

Tocris Summary for PDE8B Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE8B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE8B Gene

Genomics for PDE8B Gene

Regulatory Elements for PDE8B Gene

Genomic Location for PDE8B Gene

Start:
77,180,257 bp from pter
End:
77,429,807 bp from pter
Size:
249,551 bases
Orientation:
Plus strand

Genomic View for PDE8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE8B Gene

Proteins for PDE8B Gene

  • Protein details for PDE8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95263-PDE8B_HUMAN
    Recommended name:
    High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B
    Protein Accession:
    O95263
    Secondary Accessions:
    • Q5J7V7
    • Q86XK8
    • Q8IUJ7
    • Q8IUJ8
    • Q8IUJ9
    • Q8IUK0
    • Q8N3T2

    Protein attributes for PDE8B Gene

    Size:
    885 amino acids
    Molecular mass:
    98979 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PDE8B Gene

neXtProt entry for PDE8B Gene

Proteomics data for PDE8B Gene at MOPED

Selected DME Specific Peptides for PDE8B Gene

Post-translational modifications for PDE8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PDE8B Gene

Gene Families for PDE8B Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Suggested Antigen Peptide Sequences for PDE8B Gene

Graphical View of Domain Structure for InterPro Entry

O95263

UniProtKB/Swiss-Prot:

PDE8B_HUMAN :
  • O95263
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
genes like me logo Genes that share domains with PDE8B: view

Function for PDE8B Gene

Molecular function for PDE8B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and milrinone as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.
UniProtKB/Swiss-Prot Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland

Enzyme Numbers (IUBMB) for PDE8B Gene

Gene Ontology (GO) - Molecular Function for PDE8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity NAS 9784418
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE8B: view

Phenotypes for PDE8B Gene

genes like me logo Genes that share phenotypes with PDE8B: view

Animal Model Products

CRISPR Products

miRNA for PDE8B Gene

miRTarBase miRNAs that target PDE8B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE8B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PDE8B Gene

Localization for PDE8B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE8B Gene COMPARTMENTS Subcellular localization image for PDE8B gene
Compartment Confidence
cytosol 4
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PDE8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE8B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE8B Gene

Pathways for PDE8B Gene

genes like me logo Genes that share pathways with PDE8B: view

Pathways by source for PDE8B Gene

2 KEGG pathways for PDE8B Gene

UniProtKB/Swiss-Prot O95263-PDE8B_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

Interacting Proteins for PDE8B Gene

Gene Ontology (GO) - Biological Process for PDE8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000160 phosphorelay signal transduction system IEA --
GO:0001662 behavioral fear response IEA --
GO:0006198 cAMP catabolic process IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with PDE8B: view

Compounds for PDE8B Gene

(5) Tocris Compounds for PDE8B Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(5) HMDB Compounds for PDE8B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for PDE8B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ketotifen
  • Ketotifen Fumarate
34580-14-8 target inhibitor

(1) IUPHAR Ligand for PDE8B Gene

Ligand Type Action Affinity Pubmed IDs
dipyridamole Inhibitor Inhibition 8.5

(2) Novoseek inferred chemical compound relationships for PDE8B Gene

Compound -log(P) Hits PubMed IDs
dipyridamole 51.2 1
cgmp 36.3 1
genes like me logo Genes that share compounds with PDE8B: view

Transcripts for PDE8B Gene

Unigene Clusters for PDE8B Gene

Phosphodiesterase 8B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE8B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PDE8B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE8B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2: -
SP3: -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for PDE8B Gene

GeneLoc Exon Structure for
PDE8B
ECgene alternative splicing isoforms for
PDE8B

Expression for PDE8B Gene

mRNA expression in normal human tissues for PDE8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE8B Gene

This gene is overexpressed in Thyroid (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE8B Gene

SOURCE GeneReport for Unigene cluster for PDE8B Gene Hs.584830

mRNA Expression by UniProt/SwissProt for PDE8B Gene

O95263-PDE8B_HUMAN
Tissue specificity: Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.
genes like me logo Genes that share expressions with PDE8B: view

In Situ Assay Products

Orthologs for PDE8B Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE8B 35
  • 99.18 (n)
  • 99.36 (a)
PDE8B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE8B 35
  • 87.84 (n)
  • 93.14 (a)
PDE8B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE8B 35
  • 92.52 (n)
  • 97.8 (a)
PDE8B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde8b 35
  • 90.21 (n)
  • 97.38 (a)
Pde8b 16
Pde8b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE8B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE8B 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde8b 35
  • 90.45 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves PDE8B 35
  • 79.68 (n)
  • 85.08 (a)
PDE8B 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE8B 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde8b 35
  • 76.91 (n)
  • 84.4 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11295 35
pde8b 35
  • 71.88 (n)
  • 79.27 (a)
pde8b 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007163 35
  • 51.85 (n)
  • 44.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pde8 35
  • 50.54 (n)
  • 43.6 (a)
Pde8 36
  • 36 (a)
OneToMany
CG5411 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea pde-6 36
  • 30 (a)
OneToMany
Y95B8A.10 37
  • 39 (a)
Species with no ortholog for PDE8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE8B Gene

ENSEMBL:
Gene Tree for PDE8B (if available)
TreeFam:
Gene Tree for PDE8B (if available)

Paralogs for PDE8B Gene

Paralogs for PDE8B Gene

Selected SIMAP similar genes for PDE8B Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PDE8B Gene

genes like me logo Genes that share paralogs with PDE8B: view

Variants for PDE8B Gene

Sequence variations from dbSNP and Humsavar for PDE8B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14368 -- 77,291,673(+) CTTTG(G/T)AGGAG intron-variant
rs90682 -- 77,425,264(+) TCACA(C/T)AGAAA intron-variant
rs90683 -- 77,425,156(-) TACAA(A/G)CACAA intron-variant
rs90684 -- 77,425,152(-) AACAC(A/G)AATTC intron-variant
rs141331 -- 77,410,707(+) ACTCA(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE8B Gene

Variant ID Type Subtype PubMed ID
nsv469515 CNV Loss 16826518
esv29763 CNV Loss 19812545
nsv507265 CNV Insertion 20534489
esv2640816 CNV Deletion 19546169
esv25490 CNV Loss 19812545
esv5973 CNV Gain 19470904
nsv4889 CNV Insertion 18451855
esv2619324 CNV Insertion 19546169
esv1478247 CNV Insertion 17803354
esv271727 CNV Insertion 20981092

Relevant External Links for PDE8B Gene

HapMap Linkage Disequilibrium report
PDE8B
Human Gene Mutation Database (HGMD)
PDE8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE8B Gene

Disorders for PDE8B Gene

(2) OMIM Diseases for PDE8B Gene (603390)

UniProtKB/Swiss-Prot

PDE8B_HUMAN
  • Striatal degeneration autosomal dominant (ADSD) [MIM:609161]: A movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present. {ECO:0000269 PubMed:20085714}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Primary pigmented nodular adrenocortical disease 3 (PPNAD3) [MIM:614190]: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. {ECO:0000269 PubMed:18431404}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PDE8B Gene

Relevant External Links for PDE8B

Genetic Association Database (GAD)
PDE8B
Human Genome Epidemiology (HuGE) Navigator
PDE8B
genes like me logo Genes that share disorders with PDE8B: view

Publications for PDE8B Gene

  1. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase. (PMID: 9784418) Hayashi M. … Tanaka T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. (PMID: 18431404) Horvath A. … Stratakis C.A. (Eur. J. Hum. Genet. 2008) 3 4 23
  3. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. (PMID: 12372422) Hayashi M. … Tanaka T. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  4. Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans. (PMID: 12681444) Gamanuma M. … Omori K. (Cell. Signal. 2003) 3 4 23
  5. Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes. (PMID: 19429701) Bimpaki E.I. … Stratakis C.A. (Eur. J. Endocrinol. 2009) 3 23 48

Products for PDE8B Gene

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