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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDE8A Gene

protein-coding GIFtS: 64
GCID: GC15P085523

phosphodiesterase 8A

Explore 12 diseases affiliated with
PDE8A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphodiesterase 8A¹ ²
HsT19550¹ ²
EC 3.1.4.17³ ⁸
CAMP-Specific Cyclic Nucleotide Phosphodiesterase 8A²
High Affinity CAMP-Specific And IBMX-Insensitive 3',5'-Cyclic Phosphodiesterase 8A²

External Ids:	HGNC: 8793¹	Entrez Gene: 5151²	Ensembl: ENSG00000073417⁷	OMIM: 602972⁵	UniProtKB: O60658³

Export aliases for PDE8A gene to outside databases

Previous GC identifers: GC15P081636 GC15P078745 GC15P083110 GC15P083254 GC15P083324 GC15P061611

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE8A:

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily.

This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to

extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many

important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been

found for this gene.(provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658

Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May

be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell

development

summary for PDE8A:

Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the

hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or

cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by

controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8

selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both

cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue

distribution. These enzymes are involved in many signal transduction pathways and their functions include

vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone

secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE8A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDE8A gene promoter:
Bach1 p53 AML1a E47 GATA-1 AREB6 POU2F1 POU2F1a Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDE8A promoter sequence

Search SABiosciences Chromatin IP Primers for PDE8A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE8A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.3 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q25.3

PDE8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE8A gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P085523: view genomic region (about GC identifiers)

Start:	85,523,671 bp from pter	End:	85,682,376 bp from pter
Size:	158,706 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658 (See protein sequence)

Recommended Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Size: 829 amino acids; 93304 Da

Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a

preference for magnesium and/or manganese ions

Sequence caution: Sequence=AAL18612.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAL18613.1;

Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAL18614.1; Type=Erroneous translation; Note=Wrong

choice of CDS; Sequence=BAG54458.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=EAX01967.1;

Type=Erroneous gene model prediction;

4 PDB 3D structures from and Proteopedia for PDE8A:

1LHQ (3D)

1LXX (3D)

3ECM (3D)

3ECN (3D)

Secondary accessions: B3KXE6 H0YMZ7 Q6P9H3 Q969I1 Q96PC9 Q96PD0 Q96PD1 Q96T71 Q9UMB7 Q9UMC3

Alternative splicing: 6 isoforms: O60658-1 O60658-2 O60658-3 O60658-4 O60658-5 O60658-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDE8A: NX_O60658

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60658

2 DME Specific Peptides for PDE8A (O60658)

HDVDHPG

IDMVLAT

PDE8A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001230066.1 NP_002596.1 NP_775656.1

ENSEMBL proteins:

ENSP00000311453 ENSP00000453808 ENSP00000340679 ENSP00000432309 ENSP00000431976

ENSP00000452907 ENSP00000454094 ENSP00000378056

Reactome Protein details: O60658
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	Uscn Proteins for PDE8A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--

PDE8A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PDE8A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDE8A for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR002073 PDEase_catalytic_dom

IPR013767 PAS_fold

IPR000014 PAS

IPR023174 PDEase_CS

IPR023088 PDEase

Graphical View of Domain Structure for InterPro Entry O60658

ProtoNet protein and cluster: O60658

3 Blocks protein families:

IPB000014 PAS domain

IPB013767 PAS fold

IPB013938 3'5'-cyclic nucleotide phosphodiesterase PDE8

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658

Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal

regulatory domain

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658

Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May

be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell

development

Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

Enzyme regulation: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and zaprinast

as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP

Enzyme Number (IUBMB): EC 3.1.4.17¹ ²

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In Situ Assay
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000156	phosphorelay response regulator activity	IEA	--
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	NAS	9618252
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

PDE8A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Pde8a^tm1Dgen for PDE8A
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pde8a):

behavior/neurological

homeostasis/metabolism

integument

nervous system

PDE8A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G Protein Signaling Pathways

G Protein Signaling Pathways

1.00

Purine metabolism

Purine metabolism

1.00

G beta:gamma signalling through PLC beta

G alpha (s) signalling events

0.14

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for PDE8A

G Protein Signaling Pathways

4 Reactome Pathways for PDE8A

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (s) signalling events

1 Kegg Pathway (Kegg details for PDE8A):

Purine metabolism

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658

Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1

PDE8A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PDE8A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for PDE8A (O60658³ ENSP00000311453⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838³	I2D: score=1
NFKB2	Q00653³	I2D: score=1
NFKBIA	P25963³	I2D: score=1
NFKBIB	Q15653³	I2D: score=1
REL	Q04864³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006198	cAMP catabolic process	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0009187	cyclic nucleotide metabolic process	NAS	9618252

PDE8A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PDE8A for compounds About GeneDecksing

EMD Millipore small molecules for PDE8A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PDE8A available from Tocris Bioscience About this table

Compound	Action	CAS #
Dipyridamole	Adenosine transport inhibitor	[58-32-2]

7 HMDB Compounds for PDE8A About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Manganese	manganese	7439-96-5	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 DrugBank Compounds for PDE8A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3-ISOBUTYL-1-METHYLXANTHINE	--	--	target	--	10592235
Ketotifen	Ketotifen Fumarate (see all 5)	34580-14-8	target	inhibitor	1702263

3 Novoseek chemical compound relationships for PDE8A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vinpocetine	79.8	1	9618252 (1)
ibmx	72.1	3	9618252 (2)
cgmp	51.2	1	9618252 (1)

Search CenterWatch for drugs/clinical trials and news about PDE8A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDE8A gene (6 alternative transcripts):

NM_001243137.1 NM_002605.2 NM_173454.1 NM_173455.1 NM_173456.1 NM_173457.1

Unigene Cluster for PDE8A:

Phosphodiesterase 8A

Hs.9333 [show with all ESTs]

Unigene Representative Sequence: BC060762

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310298(uc002blh.3 uc002bli.3 uc010bnc.3 uc010bnd.3 uc002blj.3)

ENST00000557957(uc021stv.1) ENST00000339708 ENST00000478717 ENST00000485596

ENST00000559742 ENST00000559086 ENST00000560789(uc002blk.3) ENST00000557819

ENST00000558543 ENST00000557954 ENST00000561105 ENST00000561374 ENST00000560333

ENST00000561024(uc002bll.3) ENST00000394553

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		hsa-miR-376b hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-25 hsa-miR-488 hsa-miR-133a hsa-miR-92b hsa-miR-616

		SwitchGear 3'UTR luciferase reporter plasmid: PDE8A 3' UTR sequence

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Additional cDNA sequence:

AF056490.1 AF332653.1 AF388183.1 AF388184.1 AK074280.1 AL109687.1 AL109778.1 BC013825.1

BC017164.2 BC036190.1 BC037260.1 BC048317.1 BC060762.1 BC075822.1

18 DOTS entries:

DT.65286688 DT.95191818 DT.451840 DT.100788096 DT.91934162 DT.100646597 DT.100788095 DT.101961527

DT.40194645 DT.91719370 DT.100788094 DT.121033709 DT.40116709 DT.86840167 DT.86854293 DT.92415758

DT.92435159 DT.100675011

24/218 AceView cDNA sequences (see all 218):

AA626586 AL119587 AA261899 NM_173454 AI753061 AL109778 BE856478 NM_173456

BQ893257 AF056490 AV652431 BG289935 BG945104 AA594767 AW663976 BM785255

CB160291 NM_002605 AI024685 AL109687 M62032 AA262536 BE545995 CA309717

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE8A (see all 10) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	^	19	^	20a	·	20b	^
SP1:					-																				-														-						-				-
SP2:			-		-														-						-														-						-				-
SP3:					-														-						-														-						-				-
SP4:					-														-		-				-														-						-				-
SP5:					-												-		-						-														-						-				-

ExUns:	21	^	22	^	23	^	24a	·	24b	·	24c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PDE8A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDE8A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAATGTATT

About this image

PDE8A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PDE8A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE8A

SOURCE GeneReport for Unigene cluster: Hs.9333

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658

Tissue specificity: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis,

ovary, small intestine and colon

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PDE8A gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PDE8A¹	phosphodiesterase 8A	77.9(n) 79.59(a)		415455 XM_413834.3 XP_413834.2
lizard (Anolis carolinensis)	Reptilia	PDE8A⁶	--	80(a)	1 ↔ 1	GL343657.1(143623-180912)
zebrafish (Danio rerio)	Actinopterygii	pde8a¹	phosphodiesterase 8A	67.98(n) 70.69(a)		791145 NM_001080627.1 NP_001074096.1
fruit fly (Drosophila melanogaster)	Insecta	CG5411³	cAMP-specific phosphodiesterase	49(a)		--
worm (Caenorhabditis elegans)	Secernentea	Y95B8A.10³ pde-6¹	phosphodiesterase³ Protein PDE-6¹	31(a)³ 48.32(n)¹ 40.38(a)¹		I(873483-882715)³ 190808¹ NM_058386.1¹ NP_490787.1¹

ENSEMBL Gene Tree for PDE8A (if available)
TreeFam Gene Tree for PDE8A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PDE8A gene

PDE4D² PDE3A² PDE8B² PDE4B² PDE4C² PDE1B² PDE1A² PDE7B²

PDE9A² PDE1C² PDE7A² PDE4A² PDE3B²

13 SIMAP similar genes for PDE8A using alignment to 5 protein entries: PDE8A_HUMAN (see all proteins):

PDE8B PDE4B5 PDE4D PDE4C PDE4 PDE1A

PDE1C PDE3A PDE9A DKFZp686L23131 PDE1B PDE7B

PDE7B variant protein

PDE8A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7178415^1,2	C,F,H,	--	61608093(+)	`GGGCCA/TTGAGG`	1	--	us2k¹		11		NS EA NA WA CSA	666
rs111500145^1,2	F,	--	61608110(+)	`GAGTCT/CCCTGG`	1	--	us2k¹		3		CSA WA	122
rs74794963^1,2	F,	--	61608896(+)	`CAGTCC/TGGGCA`	1	--	us2k¹		1		WA	118
rs74024773^1,2	C,	--	61608914(+)	`AGGTGT/GGGGGC`	1	--	us2k¹		2		WA	120
rs74024774^1,2	C,	--	61609755(+)	`CCGCTG/ACAGGA`	3	--	ut5¹ us2k¹		1		WA	2
rs35038078^1,2	C,	--	61611710(+)	`ACACA-/TCCGAC`	3	--	int¹		0	--	--	--	--
rs16974673^1,2	C,F,H,	--	61613014(+)	`GTGCTA/TTCGCA`	3	--	int¹		11		NA NS EA WA CSA	676
rs75986826^1,2		--	61613140(+)	`CAGTGG/ACATAC`	3	--	int¹		1		EA	120
rs77954243^1,2	C,F,	--	61613334(+)	`CCATAC/GTTGTT`	3	--	int¹		1		WA	118
rs113666799^1,2		--	61613556(+)	`AATTAC/GTTTCT`	3	--	int¹		1		CSA	1

HapMap Linkage Disequilibrium report for PDE8A (85523671 - 85682376 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for PDE8A
4 CNVs: 5799 34474 34473 3975
1 Indel: 11808

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PDE8A for disorders           About GeneDecksing

OMIM gene information: 602972    OMIM disorders: --

12 diseases for PDE8A:    About MalaCards

granulomatous amebic encephalitis endolymphatic hydrops acoustic neuroma polycystic ovary syndrome

neuroma adrenocortical hyperplasia encephalitis alzheimer's disease

osteosarcoma thyroiditis malaria neuronitis

1 disease from the University of Copenhagen DISEASES database for PDE8A:

Granulomatous amebic encephalitis

Human Genome Epidemiology (HuGE) Navigator: PDE8A (4 documents)

Export disorders for PDE8A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PDE8A gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with PDE8A)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. (PubMed id 9618252)^{1, 2, 3, 9} Fisher D.A.... Cheng J.B. (1998)
Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution. (PubMed id 11738832)^{1, 2, 9} Wang P.... Billah M.M. (2001)
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. (PubMed id 18983167)^{1, 2, 9} Wang H....Ke H. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. (PubMed id 11371644)^{1, 2} Glavas N.A.... Beavo J.A. (2001)
PDE8A genetic variation, polycystic ovary syndrome an d androgen levels in women. (PubMed id 19482904)^{1, 9} Chen C....Strauss J.F. (2009)
Cyclic AMP-specific phosphodiesterase, PDE8A1, is acti vated by protein kinase A-mediated phosphorylation. (PubMed id 22673573)¹ Brown K.M....Baillie G.S. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5151	HGNC: 8793	AceView: PDE8A	Ensembl:ENSG00000073417	euGenes: HUgn5151
ECgene: PDE8A	Kegg: 5151	H-InvDB: PDE8A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PDE8A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PDE8A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PDE8A gene:
Search GeneIP for patents involving PDE8A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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