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Aliases for PDE8A Gene

Aliases for PDE8A Gene

  • Phosphodiesterase 8A 2 3 5
  • High Affinity CAMP-Specific And IBMX-Insensitive 3,5-Cyclic Phosphodiesterase 8A 3
  • CAMP-Specific Cyclic Nucleotide Phosphodiesterase 8A 3
  • EC 3.1.4.17 61
  • EC 3.1.4.53 4
  • HsT19550 3

External Ids for PDE8A Gene

Previous GeneCards Identifiers for PDE8A Gene

  • GC15P081636
  • GC15P078745
  • GC15P083110
  • GC15P083254
  • GC15P083324
  • GC15P085523
  • GC15P061611

Summaries for PDE8A Gene

Entrez Gene Summary for PDE8A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE8A Gene

PDE8A (Phosphodiesterase 8A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Purine metabolism (KEGG). GO annotations related to this gene include signal transducer activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE8B.

UniProtKB/Swiss-Prot for PDE8A Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Tocris Summary for PDE8A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE8A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE8A Gene

Genomics for PDE8A Gene

Regulatory Elements for PDE8A Gene

Enhancers for PDE8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F085013 0.8 Ensembl 19 +33.7 33661 0.6 PDE8A GC15P085023 GC15P085002
GH15F085006 0.9 Ensembl ENCODE 17.2 +28.8 28799 4.9 HDGF PKNOX1 ATF1 FEZF1 GATA2 ZNF263 REST PPARG SMARCA4 ZSCAN16 PDE8A ZNF592 ENSG00000259544 LOC101929479 ENSG00000259407 GC15P085002 GC15P085023
GH15F084954 1 Ensembl ENCODE 12.9 -25.0 -24975 1.1 ELF3 HDAC1 CBX3 ARID4B SIN3A ZNF2 RAD21 RFX5 GLIS2 ZNF143 PDE8A ENSG00000200991 NMB WDR73 ZNF592 GC15P084976 HMGB1P43
GH15F084951 0.7 ENCODE 12.8 -29.4 -29396 0.2 ATF1 TAL1 SIN3A RELA ZNF335 FOSL1 POLR2A GATA2 NCOR1 NR2F6 PDE8A ENSG00000200991 WDR73 NMB ZNF592 HMGB1P43 GC15P084976
GH15F085312 0.9 Ensembl ENCODE 5.1 +333.1 333130 3.1 CTCF PKNOX1 MXI1 WRNIP1 TEAD4 ASH2L CEBPG BMI1 ZIC2 RELA ADAMTS7P4 LOC101929479 RNU7-79P PDE8A ENSG00000259317
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PDE8A on UCSC Golden Path with GeneCards custom track

Promoters for PDE8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000412721 1660 4601 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207

Genomic Location for PDE8A Gene

Chromosome:
15
Start:
84,980,440 bp from pter
End:
85,139,145 bp from pter
Size:
158,706 bases
Orientation:
Plus strand

Genomic View for PDE8A Gene

Genes around PDE8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE8A Gene

Proteins for PDE8A Gene

  • Protein details for PDE8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60658-PDE8A_HUMAN
    Recommended name:
    High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A
    Protein Accession:
    O60658
    Secondary Accessions:
    • B3KXE6
    • H0YMZ7
    • Q6P9H3
    • Q969I1
    • Q96PC9
    • Q96PD0
    • Q96PD1
    • Q96T71
    • Q9UMB7
    • Q9UMC3

    Protein attributes for PDE8A Gene

    Size:
    829 amino acids
    Molecular mass:
    93304 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL18612.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL18613.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL18614.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG54458.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAX01967.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE8A Gene

    Alternative splice isoforms for PDE8A Gene

neXtProt entry for PDE8A Gene

Selected DME Specific Peptides for PDE8A Gene

O60658:
  • IDMVLAT
  • HDVDHPG

Post-translational modifications for PDE8A Gene

  • Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PDE8A Gene

Gene Families for PDE8A Gene

Suggested Antigen Peptide Sequences for PDE8A Gene

Graphical View of Domain Structure for InterPro Entry

O60658

UniProtKB/Swiss-Prot:

PDE8A_HUMAN :
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
genes like me logo Genes that share domains with PDE8A: view

Function for PDE8A Gene

Molecular function for PDE8A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and zaprinast as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Enzyme Numbers (IUBMB) for PDE8A Gene

Gene Ontology (GO) - Molecular Function for PDE8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity NAS 9618252
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019900 kinase binding IPI 23509299
genes like me logo Genes that share ontologies with PDE8A: view
genes like me logo Genes that share phenotypes with PDE8A: view

Animal Models for PDE8A Gene

MGI Knock Outs for PDE8A:

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE8A

miRNA for PDE8A Gene

miRTarBase miRNAs that target PDE8A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE8A Gene

Localization for PDE8A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE8A Gene COMPARTMENTS Subcellular localization image for PDE8A gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PDE8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PDE8A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE8A Gene

Pathways & Interactions for PDE8A Gene

genes like me logo Genes that share pathways with PDE8A: view

Pathways by source for PDE8A Gene

2 KEGG pathways for PDE8A Gene

UniProtKB/Swiss-Prot O60658-PDE8A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

Gene Ontology (GO) - Biological Process for PDE8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 23509299
GO:0006198 cAMP catabolic process IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0009187 cyclic nucleotide metabolic process NAS 9618252
genes like me logo Genes that share ontologies with PDE8A: view

No data available for SIGNOR curated interactions for PDE8A Gene

Drugs & Compounds for PDE8A Gene

(18) Drugs for PDE8A Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ketotifen Approved Pharma Target, inhibitor 22
Dipyridamole Approved Pharma Inhibition, Inhibitor, inhibitor Adenosine transport inhibitor 80
Caffeine Approved Nutra Antagonist, Target, inhibitor, competitive A1 and A2B antagonist. CNS stimulant 380
Cafcit Injection Approved September 1999 Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PDE8A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IBMX
Antagonist 28822-58-4

(5) Tocris Compounds for PDE8A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) 85416-75-7
IBMX PDE inhibitor (non-selective) 28822-58-4
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
Rolipram PDE4 inhibitor 61413-54-5
Sildenafil citrate Orally active, potent PDE5 inhibitor 171599-83-0
genes like me logo Genes that share compounds with PDE8A: view

Transcripts for PDE8A Gene

Unigene Clusters for PDE8A Gene

Phosphodiesterase 8A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE8A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE8A Gene

GeneLoc Exon Structure for
PDE8A
ECgene alternative splicing isoforms for
PDE8A

Expression for PDE8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDE8A Gene

Protein differential expression in normal tissues from HIPED for PDE8A Gene

This gene is overexpressed in Serum (24.1), Heart (17.4), and Plasma (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDE8A Gene



NURSA nuclear receptor signaling pathways regulating expression of PDE8A Gene:

PDE8A

SOURCE GeneReport for Unigene cluster for PDE8A Gene:

Hs.9333

mRNA Expression by UniProt/SwissProt for PDE8A Gene:

O60658-PDE8A_HUMAN
Tissue specificity: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with PDE8A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PDE8A Gene

Orthologs for PDE8A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE8A 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia PDE8A 34 35
  • 90.53 (n)
cow
(Bos Taurus)
Mammalia PDE8A 34 35
  • 87.78 (n)
mouse
(Mus musculus)
Mammalia Pde8a 34 16 35
  • 83.62 (n)
rat
(Rattus norvegicus)
Mammalia Pde8a 34
  • 82.66 (n)
oppossum
(Monodelphis domestica)
Mammalia PDE8A 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE8A 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE8A 34 35
  • 77.9 (n)
lizard
(Anolis carolinensis)
Reptilia PDE8A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde8a 34
  • 73.02 (n)
zebrafish
(Danio rerio)
Actinopterygii pde8a 34 35
  • 67.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5411 36
  • 49 (a)
Pde8 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pde-6 34 35
  • 47.38 (n)
Y95B8A.10 36
  • 31 (a)
Species where no ortholog for PDE8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE8A Gene

ENSEMBL:
Gene Tree for PDE8A (if available)
TreeFam:
Gene Tree for PDE8A (if available)

Paralogs for PDE8A Gene

Paralogs for PDE8A Gene

genes like me logo Genes that share paralogs with PDE8A: view

Variants for PDE8A Gene

Sequence variations from dbSNP and Humsavar for PDE8A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083650 -- 85,007,639(+) aatta(C/T)ttaac intron-variant
rs1011436 -- 85,004,125(-) tggct(A/G)ctgaa intron-variant
rs1011437 -- 85,004,028(-) agtaa(A/T)ctgac intron-variant
rs1014543 -- 85,004,475(+) GAGAA(C/T)AGGCT intron-variant
rs10152517 -- 85,121,171(+) gcact(C/T)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE8A Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV deletion 23128226
esv2760050 CNV gain+loss 17122850
esv3309618 CNV mobile element insertion 20981092
esv3329474 CNV insertion 20981092
esv3581796 CNV loss 25503493
esv3637104 CNV loss 21293372
nsv1037932 CNV gain 25217958
nsv1040994 CNV gain 25217958
nsv1043218 CNV gain 25217958
nsv1048509 CNV gain 25217958
nsv1052434 CNV loss 25217958
nsv1645 CNV deletion 18451855
nsv1646 CNV insertion 18451855
nsv428311 CNV gain 18775914
nsv827419 CNV gain 20364138
nsv833078 CNV loss 17160897
nsv833079 CNV gain 17160897
nsv94588 CNV deletion 16902084
nsv94721 CNV deletion 16902084

Variation tolerance for PDE8A Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDE8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE8A Gene

Disorders for PDE8A Gene

Relevant External Links for PDE8A

Genetic Association Database (GAD)
PDE8A
Human Genome Epidemiology (HuGE) Navigator
PDE8A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE8A

No disorders were found for PDE8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE8A Gene

Publications for PDE8A Gene

  1. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. (PMID: 9618252) Fisher D.A. … Cheng J.B. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  2. PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. (PMID: 19482904) Chen C. … Strauss J.F. (Mol. Hum. Reprod. 2009) 3 22 46 64
  3. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. (PMID: 18983167) Wang H. … Ke H. (Biochemistry 2008) 3 4 22 64
  4. Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution. (PMID: 11738832) Wang P. … Billah M.M. (Gene 2001) 3 4 22 64
  5. Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation. (PMID: 22673573) Brown K.M. … Baillie G.S. (FEBS Lett. 2012) 3 4 64

Products for PDE8A Gene

Sources for PDE8A Gene

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