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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDE8A Gene

protein-coding   GIFtS: 67
GCID: GC15P085523

Phosphodiesterase 8A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphodiesterase 8A1 2
EC 3.1.4.173 8
HsT195502
CAMP-Specific Cyclic Nucleotide Phosphodiesterase 8A2
High Affinity CAMP-Specific And IBMX-Insensitive 3',5'-Cyclic
Phosphodiesterase 8A2

External Ids:    HGNC: 87931   Entrez Gene: 51512   Ensembl: ENSG000000734177   OMIM: 6029725   UniProtKB: O606583   

Export aliases for PDE8A gene to outside databases

Previous GC identifers: GC15P081636 GC15P078745 GC15P083110 GC15P083254 GC15P083324 GC15P061611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE8A Gene:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8
subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of
cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein
plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for PDE8A Gene: 
PDE8A (phosphodiesterase 8A) is a protein-coding gene. Diseases associated with PDE8A include granulomatous amebic encephalitis, and endolymphatic hydrops, and among its related super-pathways are Signaling by GPCR and GABAergic synapse. GO annotations related to this gene include phosphorelay response regulator activity and 3',5'-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE3A.

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of
germ cell development

summary for PDE8A Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE8A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDE8A gene promoter:
         Bach1   p53   AML1a   E47   GATA-1   AREB6   POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE8A promoter sequence
   Search SABiosciences Chromatin IP Primers for PDE8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.3   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.3

PDE8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE8A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P085523:  view genomic region     (about GC identifiers)

Start:
85,523,671 bp from pter      End:
85,682,376 bp from pter
Size:
158,706 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658 (See protein sequence)
Recommended Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A  
Size: 829 amino acids; 93304 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions
Sequence caution: Sequence=AAL18612.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAL18613.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAL18614.1; Type=Erroneous translation; Note=Wrong
choice of CDS; Sequence=BAG54458.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=EAX01967.1;
Type=Erroneous gene model prediction;
4 PDB 3D structures from and Proteopedia for PDE8A:
1LHQ (3D)        1LXX (3D)        3ECM (3D)        3ECN (3D)    
Secondary accessions: B3KXE6 H0YMZ7 Q6P9H3 Q969I1 Q96PC9 Q96PD0 Q96PD1 Q96T71 Q9UMB7 Q9UMC3
Alternative splicing: 6 isoforms:  O60658-1   O60658-2   O60658-3   O60658-4   O60658-5   O60658-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDE8A: NX_O60658

Explore proteomics data for PDE8A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60658

  • 2 DME Specific Peptides for PDE8A (O60658)
     HDVDHPG  IDMVLAT 

    PDE8A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDE8A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001230066.1  NP_002596.1  NP_775656.1  

    ENSEMBL proteins: 
     ENSP00000311453   ENSP00000453808   ENSP00000340679   ENSP00000432309   ENSP00000431976  
     ENSP00000452907   ENSP00000454094   ENSP00000378056  
    Reactome Protein details: O60658
    Human Recombinant Protein Products for PDE8A: 
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    OriGene Protein Over-expression Lysate for PDE8A
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    Novus Biologicals PDE8A Proteins
    Novus Biologicals PDE8A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE8A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    PDE8A for ontologies           About GeneDecksing



    PDE8A Antibody Products: 
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    Cloud-Clone Corp. ELISAs for PDE8A 
    Cloud-Clone Corp. CLIAs for PDE8A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE8A 
    Phosphodiesterases, 3',5'-cyclic nucleotide

    5/7 InterPro protein domains (see all 7):
     IPR002073 PDEase_catalytic_dom
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR023174 PDEase_CS
     IPR023088 PDEase

    Graphical View of Domain Structure for InterPro Entry O60658

    ProtoNet protein and cluster: O60658

    3 Blocks protein domains:
    IPB000014 PAS domain
    IPB013767 PAS fold
    IPB013938 3'5'-cyclic nucleotide phosphodiesterase PDE8


    UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658
    Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal
    regulatory domain
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    PDE8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE8A_HUMAN, O60658
    Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
    processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of
    germ cell development
    Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
    Enzyme regulation: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and
    zaprinast as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP

         Enzyme Number (IUBMB): EC 3.1.4.171 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000156phosphorelay response regulator activity IEA--
    GO:0003824catalytic activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity NAS9618252
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IEA--
    GO:0004871signal transducer activity ----
         
    PDE8A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pde8a):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    PDE8A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pde8atm1Dgen for PDE8A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDE8A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDE8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDE8A 
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    miRNA
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    hsa-miR-376b hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-25 hsa-miR-488 hsa-miR-133a hsa-miR-92b hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidPDE8A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE8A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDE8A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Circadian entrainment
    Morphine addiction0.53
    3Signal transduction cAMP signaling
    G Protein Signaling Pathways0.44
    4Purine metabolism
    Purine metabolism0.38
    5Prostacyclin signalling through prostacyclin receptor
    G alpha (s) signalling events0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PDE8A
        G Protein Signaling Pathways

    4        Reactome Pathways for PDE8A
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (s) signalling events


    2         Kegg Pathways  (Kegg details for PDE8A):
        Purine metabolism
    Morphine addiction

    UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658
    Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1


    PDE8A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDE8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for PDE8A (O606583 ENSP000003114534) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198383I2D: score=1 
    NFKB2Q006533I2D: score=1 
    NFKBIAP259633I2D: score=1 
    NFKBIBQ156533I2D: score=1 
    RELQ048643I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000160phosphorelay signal transduction system ----
    GO:0006198cAMP catabolic process IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007165signal transduction ----
    GO:0009187cyclic nucleotide metabolic process NAS9618252

    PDE8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDE8A for compounds           About GeneDecksing

    EMD Millipore small molecules for PDE8A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDE8A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    7 HMDB Compounds for PDE8A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PDE8A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-ISOBUTYL-1-METHYLXANTHINE-- --target--10592235
    KetotifenKetotifen Fumarate (see all 5)34580-14-8targetinhibitor1702263

    1 IUPHAR Ligand for PDE8A (PDE8A)    About this table 
    LigandTypeActionAffinityPubmed IDs
    dipyridamole
    InhibitorInhibition5.19618252

    3 Novoseek inferred chemical compound relationships for PDE8A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vinpocetine 79.8 1 9618252 (1)
    ibmx 72.1 3 9618252 (2)
    cgmp 51.2 1 9618252 (1)

    Search CenterWatch for drugs/clinical trials and news about PDE8A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDE8A gene (6 alternative transcripts): 
    NM_001243137.1  NM_002605.2  NM_173454.1  NM_173455.1  NM_173456.1  NM_173457.1  

    Unigene Cluster for PDE8A:

    Phosphodiesterase 8A
    Hs.9333  [show with all ESTs]
    Unigene Representative Sequence: BC060762
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310298(uc002blh.3 uc002bli.3 uc010bnc.3 uc010bnd.3 uc002blj.3)
    ENST00000557957(uc021stv.1) ENST00000339708 ENST00000478717 ENST00000485596
    ENST00000559742 ENST00000559086 ENST00000560789(uc002blk.3) ENST00000557819
    ENST00000558543 ENST00000557954 ENST00000561105 ENST00000561374 ENST00000560333
    ENST00000561024(uc002bll.3) ENST00000394553

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    Additional mRNA sequence: 

    AF056490.1 AF332653.1 AF388183.1 AF388184.1 AK074280.1 AL109687.1 AL109778.1 BC013825.1 
    BC017164.2 BC036190.1 BC037260.1 BC048317.1 BC060762.1 BC075822.1 

    18 DOTS entries:

    DT.65286688  DT.95191818  DT.451840  DT.100788096  DT.91934162  DT.100646597  DT.100788095  DT.101961527 
    DT.40194645  DT.91719370  DT.100788094  DT.121033709  DT.40116709  DT.86840167  DT.86854293  DT.92415758 
    DT.92435159  DT.100675011 

    24/218 AceView cDNA sequences (see all 218):

    AA626586 BC017164 BQ652583 AA978077 BC048317 BU541542 BU186663 BM796665 
    AI040460 CA412830 BU687332 AI138623 BQ775306 BU165273 AI205629 AA628291 
    CA309717 BE545995 M62032 AA262536 AL109687 AI024685 NM_002605 BM785255 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE8A (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^
    SP1:              -                                                           -                                         -                 -           -         
    SP2:        -     -                                         -                 -                                         -                 -           -         
    SP3:              -                                         -                 -                                         -                 -           -         
    SP4:              -                                         -     -           -                                         -                 -           -         
    SP5:              -                                   -     -                 -                                         -                 -           -         

    ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for PDE8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDE8A expression in normal human tissues (normalized intensities)      PDE8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATGTATT
    PDE8A Expression
    About this image


    PDE8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
             hippocampus   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             rectum ; glandular cells   
             colonic mucosal (ibs)   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See PDE8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDE8A

    SOURCE GeneReport for Unigene cluster: Hs.9333

    UniProtKB/Swiss-Prot: PDE8A_HUMAN, O60658
    Tissue specificity: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in
    testis, ovary, small intestine and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDE8A gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde8a1 , 5 phosphodiesterase 8A1, 5 83.62(n)1
    81.53(a)1
      7 (45.71 cM)5
    185841  NM_008803.21  NP_032829.11 
     812135965 
    chicken
    (Gallus gallus)
    Aves PDE8A1 phosphodiesterase 8A 77.9(n)
    79.59(a)
      415455  XM_413834.3  XP_413834.2 
    lizard
    (Anolis carolinensis)
    Reptilia PDE8A6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343657.1(143623-183626)
    zebrafish
    (Danio rerio)
    Actinopterygii pde8a1 phosphodiesterase 8A 67.98(n)
    70.69(a)
      791145  NM_001080627.1  NP_001074096.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54113 cAMP-specific phosphodiesterase 49(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y95B8A.103
    pde-61
    phosphodiesterase3
    Protein PDE-61
    31(a)3
    48.32(n)1
    40.38(a)1
      I(873483-882715)3
    1908081  NM_058386.11  NP_490787.11 


    ENSEMBL Gene Tree for PDE8A (if available)
    TreeFam Gene Tree for PDE8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDE8A gene
    PDE3A2  PDE4D2  PDE8B2  PDE4B2  PDE4C2  PDE7B2  PDE1B2  PDE1A2  
    PDE9A2  PDE1C2  PDE7A2  PDE3B2  PDE4A2  
    13 SIMAP similar genes for PDE8A using alignment to 5 protein entries:     PDE8A_HUMAN (see all proteins):
    PDE8B    PDE4B5    PDE4D    PDE4C    PDE4    PDE1A
    PDE1C    PDE3A    PDE9A    DKFZp686L23131    PDE1B    PDE7B
    PDE7B variant protein

    PDE8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3456 SNPs in PDE8A are shown (see all 3456)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358189841,2
    C--61633956(+) TATTC-/T/TT  
            
    TTTTT
    3 -- int11NA 2
    rs677234561,2
    C--61639982(+) CCCCA-/TGTCGT 3 -- int10--------
    rs1135434161,2
    C--61671211(+) ACCAAT/-TTTTT 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs3773691,2
    C,F,A--61671223(+) TTTTTA/TAATAA 3 -- int1 trp37Minor allele frequency- T:0.45NA WA EA 366
    rs2003988781,2
    C--61671223(+) TTTTT-/A/TAATAA 3 -- int10--------
    rs113084981,2
    C,F--61695156(+) AGCAA-/T/TT  
            
    TTTTT
    3 -- int1 trp33NA CSA 6
    rs2005777251,2
    --61695165(+) TTTTT-/TAACTTG 3 -- int10--------
    rs344506651,2
    C--61702098(+) CATGGT/-TGGCA 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs340050571,2
    C--61707376(+) AAAAC-/AG/GA 
            
    AAGAC
    3 -- int11NA 2
    rs340391171,2
    C--61711349(+) ACCTC-/TTGTCA 3 -- int10--------

    HapMap Linkage Disequilibrium report for PDE8A (85523671 - 85682376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for PDE8A (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672879CNV Deletion23128226
    nsv1646CNV Insertion18451855
    esv273890CNV Insertion20981092
    nsv94721CNV Loss16902084
    nsv833078CNV Loss17160897
    nsv94588CNV Loss16902084
    nsv1645CNV Loss18451855
    nsv827419CNV Gain20364138
    nsv428311CNV Gain18775914
    nsv833079CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602972    OMIM disorders: --

    10 diseases for PDE8A:    About MalaCards
    granulomatous amebic encephalitis    endolymphatic hydrops    acoustic neuroma    neuroma
    encephalitis    polycystic ovary syndrome    osteosarcoma    alzheimer's disease
    thyroiditis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PDE8A:
    Granulomatous amebic encephalitis

    PDE8A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PDE8A
    Human Genome Epidemiology (HuGE) Navigator: PDE8A (4 documents)

    Export disorders for PDE8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDE8A gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with PDE8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. (PubMed id 9618252)1, 2, 3, 9 Fisher D.A.... Cheng J.B. (1998)
    2. Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution. (PubMed id 11738832)1, 2, 9 Wang P.... Billah M.M. (2001)
    3. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. (PubMed id 18983167)1, 2, 9 Wang H....Ke H. (2008)
    4. PDE8A genetic variation, polycystic ovary syndrome an d androgen levels in women. (PubMed id 19482904)1, 4, 9 Chen C....Strauss J.F. (2009)
    5. Cyclic AMP-specific phosphodiesterase, PDE8A1, is acti vated by protein kinase A-mediated phosphorylation. (PubMed id 22673573)1, 2 Brown K.M....Baillie G.S. (2012)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. (PubMed id 11371644)1, 2 Glavas N.A.... Beavo J.A. (2001)
    10. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5151 HGNC: 8793 AceView: PDE8A Ensembl:ENSG00000073417 euGenes: HUgn5151
    ECgene: PDE8A Kegg: 5151 H-InvDB: PDE8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDE8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDE8A gene:
    Search GeneIP for patents involving PDE8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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