Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDE8A Gene

Aliases for PDE8A Gene

  • Phosphodiesterase 8A 2 3
  • High Affinity CAMP-Specific And IBMX-Insensitive 3,5-Cyclic Phosphodiesterase 8A 3
  • CAMP-Specific Cyclic Nucleotide Phosphodiesterase 8A 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4
  • HsT19550 3

External Ids for PDE8A Gene

Previous GeneCards Identifiers for PDE8A Gene

  • GC15P081636
  • GC15P078745
  • GC15P083110
  • GC15P083254
  • GC15P083324
  • GC15P085523
  • GC15P061611

Summaries for PDE8A Gene

Entrez Gene Summary for PDE8A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE8A Gene

PDE8A (Phosphodiesterase 8A) is a Protein Coding gene. Diseases associated with PDE8A include granulomatous amebic encephalitis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and phosphorelay response regulator activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE8A Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Tocris Summary for PDE8A Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE8A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE8A Gene

Genomics for PDE8A Gene

Regulatory Elements for PDE8A Gene

Genomic Location for PDE8A Gene

Start:
84,980,440 bp from pter
End:
85,139,145 bp from pter
Size:
158,706 bases
Orientation:
Plus strand

Genomic View for PDE8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE8A Gene

Proteins for PDE8A Gene

  • Protein details for PDE8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60658-PDE8A_HUMAN
    Recommended name:
    High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A
    Protein Accession:
    O60658
    Secondary Accessions:
    • B3KXE6
    • H0YMZ7
    • Q6P9H3
    • Q969I1
    • Q96PC9
    • Q96PD0
    • Q96PD1
    • Q96T71
    • Q9UMB7
    • Q9UMC3

    Protein attributes for PDE8A Gene

    Size:
    829 amino acids
    Molecular mass:
    93304 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL18612.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL18613.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL18614.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG54458.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAX01967.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE8A Gene

    Alternative splice isoforms for PDE8A Gene

neXtProt entry for PDE8A Gene

Proteomics data for PDE8A Gene at MOPED

Selected DME Specific Peptides for PDE8A Gene

Post-translational modifications for PDE8A Gene

  • Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE8A Gene

Domains for PDE8A Gene

Gene Families for PDE8A Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Suggested Antigen Peptide Sequences for PDE8A Gene

Graphical View of Domain Structure for InterPro Entry

O60658

UniProtKB/Swiss-Prot:

PDE8A_HUMAN :
  • O60658
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
genes like me logo Genes that share domains with PDE8A: view

Function for PDE8A Gene

Molecular function for PDE8A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and zaprinast as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP
UniProtKB/Swiss-Prot Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Enzyme Numbers (IUBMB) for PDE8A Gene

Gene Ontology (GO) - Molecular Function for PDE8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity NAS 9618252
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE8A: view
genes like me logo Genes that share phenotypes with PDE8A: view

miRNA for PDE8A Gene

miRTarBase miRNAs that target PDE8A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PDE8A Gene

Localization for PDE8A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE8A Gene COMPARTMENTS Subcellular localization image for PDE8A gene
Compartment Confidence
cytosol 4
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PDE8A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE8A Gene

Pathways for PDE8A Gene

genes like me logo Genes that share pathways with PDE8A: view

Pathways by source for PDE8A Gene

2 KEGG pathways for PDE8A Gene

UniProtKB/Swiss-Prot O60658-PDE8A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

Interacting Proteins for PDE8A Gene

Gene Ontology (GO) - Biological Process for PDE8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000160 phosphorelay signal transduction system IEA --
GO:0006198 cAMP catabolic process IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction --
GO:0009187 cyclic nucleotide metabolic process NAS 9618252
genes like me logo Genes that share ontologies with PDE8A: view

Compounds for PDE8A Gene

(5) Tocris Compounds for PDE8A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(7) HMDB Compounds for PDE8A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Magnesium
  • Magnesium
7439-95-4

(2) Drugbank Compounds for PDE8A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-ISOBUTYL-1-METHYLXANTHINE
target
Ketotifen
  • Ketotifen Fumarate
34580-14-8 target inhibitor

(1) IUPHAR Ligand for PDE8A Gene

Ligand Type Action Affinity Pubmed IDs
dipyridamole Inhibitor Inhibition 8.5

(3) Novoseek inferred chemical compound relationships for PDE8A Gene

Compound -log(P) Hits PubMed IDs
vinpocetine 79.8 1
ibmx 72.1 2
cgmp 51.2 1
genes like me logo Genes that share compounds with PDE8A: view

Transcripts for PDE8A Gene

Unigene Clusters for PDE8A Gene

Phosphodiesterase 8A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE8A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE8A Gene

GeneLoc Exon Structure for
PDE8A
ECgene alternative splicing isoforms for
PDE8A

Expression for PDE8A Gene

mRNA expression in normal human tissues for PDE8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE8A Gene

SOURCE GeneReport for Unigene cluster for PDE8A Gene Hs.9333

mRNA Expression by UniProt/SwissProt for PDE8A Gene

O60658-PDE8A_HUMAN
Tissue specificity: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon
genes like me logo Genes that share expressions with PDE8A: view

No data available for mRNA differential expression in normal tissues for PDE8A Gene

Orthologs for PDE8A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE8A 35
  • 99.72 (n)
  • 99.76 (a)
PDE8A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE8A 35
  • 87.78 (n)
  • 86.97 (a)
PDE8A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE8A 35
  • 90.53 (n)
  • 91.94 (a)
PDE8A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde8a 35
  • 83.62 (n)
  • 81.53 (a)
Pde8a 16
Pde8a 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE8A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE8A 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde8a 35
  • 82.66 (n)
  • 80.49 (a)
chicken
(Gallus gallus)
Aves PDE8A 35
  • 77.9 (n)
  • 79.59 (a)
PDE8A 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE8A 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde8a 35
  • 73.02 (n)
  • 75.51 (a)
zebrafish
(Danio rerio)
Actinopterygii pde8a 35
  • 67.98 (n)
  • 70.69 (a)
pde8a 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pde8 36
  • 34 (a)
OneToMany
CG5411 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea pde-6 35
  • 47.38 (n)
  • 38.86 (a)
pde-6 36
  • 29 (a)
OneToMany
Y95B8A.10 37
  • 31 (a)
Species with no ortholog for PDE8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE8A Gene

ENSEMBL:
Gene Tree for PDE8A (if available)
TreeFam:
Gene Tree for PDE8A (if available)

Paralogs for PDE8A Gene

Paralogs for PDE8A Gene

genes like me logo Genes that share paralogs with PDE8A: view

Variants for PDE8A Gene

Sequence variations from dbSNP and Humsavar for PDE8A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs167036 -- 85,011,723(-) ctgtg(C/T)agaag intron-variant
rs182326 -- 85,019,821(-) gggca(A/G)atcac intron-variant
rs185972 -- 85,013,653(-) ctttg(C/G)ggtaa intron-variant
rs185973 -- 85,019,869(-) catag(G/T)ggctc intron-variant
rs188295 -- 85,012,249(-) acata(C/T)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE8A Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV Deletion 23128226
nsv827419 CNV Gain 20364138
nsv833078 CNV Loss 17160897
nsv94588 CNV Loss 16902084
nsv1645 CNV Loss 18451855
nsv833079 CNV Gain 17160897
nsv1646 CNV Insertion 18451855
esv273890 CNV Insertion 20981092
dgv771e1 CNV Complex 17122850
nsv428311 CNV Gain 18775914
nsv94721 CNV Loss 16902084

Relevant External Links for PDE8A Gene

HapMap Linkage Disequilibrium report
PDE8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE8A Gene

Disorders for PDE8A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PDE8A Gene including...

Search for PDE8A Gene in MalaCards »

(1) University of Copenhagen DISEASES for PDE8A Gene

Relevant External Links for PDE8A

Genetic Association Database (GAD)
PDE8A
Human Genome Epidemiology (HuGE) Navigator
PDE8A
genes like me logo Genes that share disorders with PDE8A: view

No data available for UniProtKB/Swiss-Prot for PDE8A Gene

Publications for PDE8A Gene

  1. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. (PMID: 9618252) Fisher D.A. … Cheng J.B. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution. (PMID: 11738832) Wang P. … Billah M.M. (Gene 2001) 3 4 23
  3. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. (PMID: 18983167) Wang H. … Ke H. (Biochemistry 2008) 3 4 23
  4. PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. (PMID: 19482904) Chen C. … Strauss J.F. (Mol. Hum. Reprod. 2009) 3 23 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for PDE8A Gene

Sources for PDE8A Gene

Back to Top

Content