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PDE7B Gene

protein-coding   GIFtS: 56
GCID: GC06P136214

Phosphodiesterase 7B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphodiesterase 7B1 2     Rolipram-Insensitive Phosphodiesterase Type 72
bA472E5.12     EC 3.1.4.533
CAMP-Specific 3',5'-Cyclic Phosphodiesterase 7B2     EC 3.1.48
High-Affinity CAMP-Specific 3',5'-Cyclic Phosphodiesterase2     EC 3.1.4.178

External Ids:    HGNC: 87921   Entrez Gene: 271152   Ensembl: ENSG000001714087   OMIM: 6046455   UniProtKB: Q9NP563   

Export aliases for PDE7B gene to outside databases

Previous GC identifers: GC06P135795 GC06P136019 GC06P136153 GC06P133737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDE7B Gene:
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction
pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the
corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene
encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.(provided
by RefSeq, Apr 2009)

GeneCards Summary for PDE7B Gene:
PDE7B (phosphodiesterase 7B) is a protein-coding gene. GO annotations related to this gene include 3',5'-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4D.

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PDE7B gene promoter:
         POU2F1   POU2F1a   Chx10   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE7B promoter sequence
   Search Chromatin IP Primers for PDE7B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q23-q24

PDE7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE7B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P136214:  view genomic region     (about GC identifiers)

Start:
136,172,834 bp from pter      End:
136,516,712 bp from pter
Size:
343,879 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56 (See protein sequence)
Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B  
Size: 450 amino acids; 51835 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions (By similarity)
1 PDB 3D structure from and Proteopedia for PDE7B:
1LXW (3D)    
Secondary accessions: Q5W154

Explore the universe of human proteins at neXtProt for PDE7B: NX_Q9NP56

Explore proteomics data for PDE7B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE7B (Q9NP56) (see all 7)
     HAADVTQ  HDVDHPG  SVLENHH  RLLSFQRY 


    See PDE7B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061818.1  
    ENSEMBL proteins: 
     ENSP00000310661   ENSP00000403732  
    Reactome Protein details: Q9NP56

    PDE7B Human Recombinant Protein Products:

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    Novus Biologicals PDE7B Proteins
    Novus Biologicals PDE7B Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE7B

     
    Search eBioscience for Proteins for PDE7B 

     
    antibodies-online proteins for PDE7B (6 products) 

     
    antibodies-online peptides for PDE7B

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    Cloud-Clone Corp. ELISAs for PDE7B
    Cloud-Clone Corp. CLIAs for PDE7B
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    antibodies-online kits for PDE7B (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE7B
    Phosphodiesterases, 3',5'-cyclic nucleotide

    4 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NP56

    ProtoNet protein and cluster: Q9NP56

    UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
    Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal
    regulatory domain
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily


    Find genes that share domains with PDE7B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE7B_HUMAN, Q9NP56
    Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
    processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain
    Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
    Enzyme regulation: Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and
    milrinone

         Enzyme Numbers (IUBMB): EC 3.1.4.172 EC 3.1.4.531 EC 3.1.42

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PDE7B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PDE7B:
     Increased S DNA content  Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PDE7B

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    Selected qRT-PCR Assays for microRNAs that regulate PDE7B (see all 101):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-128 hsa-miR-374a hsa-miR-3142 hsa-miR-200b hsa-miR-192*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat PDE7B

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    GenScript: all cDNA clones in your preferred vector: PDE7B (NM_018945)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE7B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PDE7B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDE7B About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Circadian entrainment
    Morphine addiction0.53
    3G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    4Purine metabolism (KEGG)
    Purine metabolism0.38
    5G alpha (s) signalling events
    G alpha (s) signalling events


    Find genes that share SuperPaths with PDE7B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PDE7B
        G Protein Signaling Pathways

    1 Reactome Pathway for PDE7B
        G alpha (s) signalling events


    2 Kegg Pathways  (Kegg details for PDE7B):
        Purine metabolism
    Morphine addiction

    UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
    Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDE7B
    Interactions:

        Search GeneGlobe Interaction Network for PDE7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE7B (ENSP000003106614) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY3ENSP000002606004STRING: ENSP00000260600
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006198cAMP catabolic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007268synaptic transmission TAS10814504

    Find genes that share ontologies with PDE7B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDE7B

    5 HMDB Compounds for PDE7B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PDE7B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetinhibitor17139284 17016423
    KetotifenKetotifen Fumarate (see all 5)34580-14-8targetinhibitor17139284 17016423

    2 IUPHAR Ligands for PDE7B (PDE7B)    About this table
    LigandTypeActionAffinityPubmed IDs
    dipyridamole
    InhibitorInhibition5.7 - 610814504 10872825
    SCH51866
    InhibitorInhibition5.810814504

    2 Novoseek inferred chemical compound relationships for PDE7B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sch51866 98.2 1 10814504 (1)
    dipyridamole 59.6 1 10814504 (1)



    Find genes that share compounds with PDE7B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE7B gene: 
    NM_018945.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308191(uc003qgp.3 uc003qgr.3) ENST00000446774
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PDE7B (see all 101):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-128 hsa-miR-374a hsa-miR-3142 hsa-miR-200b hsa-miR-192*
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    Selected AceView cDNA sequences (see all 59):

    BX095790 CF125521 AF086025 AI431726 BC075082 H88677 BM726183 BX118073 
    CF125595 N69957 AW271704 CD677756 BC075083 CF552286 BF939312 BX480641 
    AJ251860 AI743893 BQ051375 AI638433 BU150635 CB957492 H88726 AW301623 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDE7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCATCAAT
    PDE7B Expression
    About this image


    PDE7B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte progenitor cells
    PDE7B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE7B Protein Expression

    UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
    Tissue specificity: Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PDE7B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde7b1 , 5 phosphodiesterase 7B1, 5 89.96(n)1
    92.81(a)1
      10 (9.75 cM)5
    298631  NM_013875.51  NP_038903.31 
     203980045 
    chicken
    (Gallus gallus)
    Aves PDE7B1 phosphodiesterase 7B 80.92(n)
    86.7(a)
      421692  XM_419729.4  XP_419729.3 
    lizard
    (Anolis carolinensis)
    Reptilia PDE7B6
    phosphodiesterase 7B
    86(a)
    1 ↔ 1
    GL343200.1(2517137-2722437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX741394.12   -- 76.52(n)    BX741394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR848033.16
    Uncharacterized protein
    18(a)
    many ↔ many
    15(21296054-21308000) ENSDARG00000076650


    ENSEMBL Gene Tree for PDE7B (if available)
    TreeFam Gene Tree for PDE7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE7B gene
    PDE4D2  PDE8B2  PDE4B2  PDE4C2  PDE1B2  PDE1A2  PDE9A2  PDE1C2  
    PDE7A2  PDE8A2  PDE4A2  
    8 SIMAP similar genes for PDE7B using alignment to 4 protein entries:     PDE7B_HUMAN (see all proteins):
    PDE7B variant protein    PDE7A    PDE7    PDE4    PDE4B    PDE4D
    PDE4C    PDE8A

    Find genes that share paralogs with PDE7B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE7B (see all 6060)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58802661,2
    C--133751030(+) GGCAT-/TG    
       
    /TGTG
    TGTGT
    1 -- int10--------
    rs1444691081,2
    C--133757339(+) TGTAT-/AC    
       
    /CACA
    ACACA
    1 -- int10--------
    rs1834481941,2
    --133757362(+) ACACAC/TATATA 1 -- int10--------
    rs557778021,2
    C--133782854(+) GTGTG-/TGGGTAT 1 -- int11Minor allele frequency- TG:0.00NA 2
    rs710067771,2
    C--133800221(-) ATTAGC/-CGGGC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs45668971,2
    C,A--133834499(+) atagaC/Tagaca 1 -- int10--------
    rs1386385591,2
    C--133837030(+) AAAAC-/AGAGTTT 1 -- int10--------
    rs1857622161,2
    --133917360(+) AAAAAA/CAAAAA 1 -- int10--------
    rs1923272221,2
    --133917361(+) AAAAAA/CAAAAA 1 -- int10--------
    rs2008265921,2
    C--133965322(+) GAAGAA/CAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PDE7B (136172834 - 136422834 bp, first 250kb of PDE7B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDE7B (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667637CNV Deletion23128226
    esv2657421CNV Deletion23128226
    esv2732744CNV Deletion23290073
    esv2732745CNV Deletion23290073
    esv2263540CNV Deletion18987734
    esv2530297CNV Deletion19546169
    esv2919CNV Deletion18987735
    esv1491990CNV Insertion17803354
    esv274646CNV Insertion20981092
    esv268004CNV Insertion20981092

    Human Gene Mutation Database (HGMD): PDE7B
    Locus Specific Mutation Databases (LSDB): PDE7B

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604645    OMIM disorders: --


    Find genes that share disorders with PDE7B           About GenesLikeMe

    Genetic Association Database (GAD): PDE7B
    Human Genome Epidemiology (HuGE) Navigator: PDE7B (8 documents)

    Export disorders for PDE7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE7B gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with PDE7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human PDE7B, a cAMP-specific phosphodiesterase. (PubMed id 10814504)1, 2, 9 Sasaki T.... Omori K. (Biochem. Biophys. Res. Commun. 2000)
    2. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. (PubMed id 10618442)1, 3, 9 Hetman J.M....Beavo J.A. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (Biol. Psychiatry 2010)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase. (PubMed id 10872825)1, 2 Gardner C.E.... Fidock M.D. (Biochem. Biophys. Res. Commun. 2000)
    8. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. (PubMed id 19033455)1, 9 Zhang L....Insel P.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Genome-wide association study and meta-analysis of intraocular pressure. (PubMed id 24002674)1 Ozel A.B....Li J.Z. (Hum. Genet. 2014)
    10. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27115 HGNC: 8792 AceView: PDE7B Ensembl:ENSG00000171408 euGenes: HUgn27115
    ECgene: PDE7B Kegg: 27115 H-InvDB: PDE7B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDE7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE7B gene:
    Search GeneIP for patents involving PDE7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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