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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDE7B Gene

protein-coding   GIFtS: 60
GCID: GC06P136214

Phosphodiesterase 7B

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphodiesterase 7B1 2     High-Affinity CAMP-Specific 3',5'-Cyclic Phosphodiesterase2
EC 3.1.4.173 8     Rolipram-Insensitive Phosphodiesterase Type 72
bA472E5.12     EC 3.1.48
CAMP-Specific 3',5'-Cyclic Phosphodiesterase 7B2     

External Ids:    HGNC: 87921   Entrez Gene: 271152   Ensembl: ENSG000001714087   OMIM: 6046455   UniProtKB: Q9NP563   

Export aliases for PDE7B gene to outside databases

Previous GC identifers: GC06P135795 GC06P136019 GC06P136153 GC06P133737


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE7B Gene:
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction
pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the
corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene
encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.(provided
by RefSeq, Apr 2009)

GeneCards Summary for PDE7B Gene: 
PDE7B (phosphodiesterase 7B) is a protein-coding gene. Diseases associated with PDE7B include dyslexia, and mantle cell lymphoma, and among its related super-pathways are Signaling by GPCR and GABAergic synapse. GO annotations related to this gene include 3',5'-cyclic-AMP phosphodiesterase activity and metal ion binding. An important paralog of this gene is PDE3A.

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDE7B gene promoter:
         POU2F1   POU2F1a   Chx10   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE7B promoter sequence
   Search SABiosciences Chromatin IP Primers for PDE7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q23-q24

PDE7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE7B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P136214:  view genomic region     (about GC identifiers)

Start:
136,172,834 bp from pter      End:
136,516,712 bp from pter
Size:
343,879 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56 (See protein sequence)
Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B  
Size: 450 amino acids; 51835 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions (By similarity)
1 PDB 3D structure from and Proteopedia for PDE7B:
1LXW (3D)    
Secondary accessions: Q5W154

Explore the universe of human proteins at neXtProt for PDE7B: NX_Q9NP56

Explore proteomics data for PDE7B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NP56

  • 4/7 DME Specific Peptides for PDE7B (Q9NP56) (see all 7)
     HAADVTQ  HDVDHPG  SVLENHH  RLLSFQRY 

    PDE7B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDE7B Protein Expression
    REFSEQ proteins: NP_061818.1  
    ENSEMBL proteins: 
     ENSP00000310661   ENSP00000403732  
    Reactome Protein details: Q9NP56
    Human Recombinant Protein Products for PDE7B: 
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    Novus Biologicals PDE7B Proteins
    Novus Biologicals PDE7B Lysates
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE7B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    PDE7B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE7B 
    Phosphodiesterases, 3',5'-cyclic nucleotide

    4 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NP56

    ProtoNet protein and cluster: Q9NP56

    UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
    Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal
    regulatory domain
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily


    PDE7B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE7B_HUMAN, Q9NP56
    Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
    processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain
    Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
    Enzyme regulation: Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and
    milrinone

         Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IEA--
    GO:0046872metal ion binding IEA--
         
    PDE7B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PDE7B:
     Increased S DNA content  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDE7B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDE7B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Circadian entrainment
    Morphine addiction0.53
    3Signal transduction cAMP signaling
    G Protein Signaling Pathways0.44
    4Purine metabolism
    Purine metabolism0.38
    5Prostacyclin signalling through prostacyclin receptor
    G alpha (s) signalling events0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PDE7B
        G Protein Signaling Pathways

    4        Reactome Pathways for PDE7B
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (s) signalling events


    2         Kegg Pathways  (Kegg details for PDE7B):
        Purine metabolism
    Morphine addiction

    UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
    Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1


    PDE7B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDE7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for PDE7B (ENSP000003106614) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY3ENSP000002606004STRING: ENSP00000260600
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006198cAMP catabolic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007268synaptic transmission TAS10814504

    PDE7B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDE7B for compounds           About GeneDecksing

    EMD Millipore small molecules for PDE7B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDE7B

    5 HMDB Compounds for PDE7B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PDE7B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetinhibitor17139284 17016423
    KetotifenKetotifen Fumarate (see all 5)34580-14-8targetinhibitor17139284 17016423

    2 IUPHAR Ligands for PDE7B (PDE7B)    About this table 
    LigandTypeActionAffinityPubmed IDs
    dipyridamole
    InhibitorInhibition5.7 - 610814504 10872825
    SCH51866
    InhibitorInhibition5.810814504

    2 Novoseek inferred chemical compound relationships for PDE7B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sch51866 98.2 1 10814504 (1)
    dipyridamole 59.6 1 10814504 (1)

    Search CenterWatch for drugs/clinical trials and news about PDE7B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDE7B gene: 
    NM_018945.3  

    Unigene Cluster for PDE7B:

    Phosphodiesterase 7B
    Hs.744230  [show with all ESTs]
    Unigene Representative Sequence: AB209990
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308191(uc003qgp.3 uc003qgr.3) ENST00000446774

    miRNA
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    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-128 hsa-miR-374a hsa-miR-3142 hsa-miR-200b hsa-miR-192*
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    Additional mRNA sequence: 

    AB038040.1 AB209990.1 AF086025.1 AJ251860.1 AK290582.1 BC070267.1 BC075082.2 BC075083.2 
    EF108327.1 

    6 DOTS entries:

    DT.423433  DT.100653870  DT.408060  DT.100646287  DT.40128101  DT.100736387 

    24/59 AceView cDNA sequences (see all 59):

    BX118073 CF125595 N69957 AW271704 CD677756 BC075083 AF086025 CF125521 
    AI431726 BC075082 H88677 BM726183 CF552286 BX095790 BM682610 NM_018945 
    AI961166 AW138785 AI953675 AA099585 AA974161 AW195102 AB038040 BC070267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDE7B expression in normal human tissues (normalized intensities)      PDE7B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCATCAAT
    PDE7B Expression
    About this image


    PDE7B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor EN7
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Hair
             Human Hair Dermal Papilla Cells (HHDPC)   
             mouse/organ system/integumental system   
     
     Tooth
             Dental pulp Stem Cells (DPSC)   
             mouse/organ system/integumental system   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
             mouse/organ system/cardiovascular system   

    See PDE7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDE7B

    SOURCE GeneReport for Unigene cluster: Hs.744230

    UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56
    Tissue specificity: Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE7B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDE7B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde7b1 , 5 phosphodiesterase 7B1, 5 89.96(n)1
    92.81(a)1
      10 (9.75 cM)5
    298631  NM_013875.51  NP_038903.31 
     203980045 
    chicken
    (Gallus gallus)
    Aves PDE7B1 phosphodiesterase 7B 81.09(n)
    87.26(a)
      421692  XM_419729.3  XP_419729.3 
    lizard
    (Anolis carolinensis)
    Reptilia PDE7B6
    phosphodiesterase 7B
    86(a)
    1 ↔ 1
    GL343200.1(2517137-2722437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX741394.12   -- 76.52(n)    BX741394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    27(a)
    possible ortholog
    9(20503254-20508199)
    worm
    (Caenorhabditis elegans)
    Secernentea pde-36
    Probable 3',5'-cyclic phosphodiesterase pde-3
    15(a)
    1 → many
    II(14919705-14953312)


    ENSEMBL Gene Tree for PDE7B (if available)
    TreeFam Gene Tree for PDE7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDE7B gene
    PDE3A2  PDE4D2  PDE8B2  PDE4B2  PDE4C2  PDE1B2  PDE1A2  PDE9A2  
    PDE1C2  PDE7A2  PDE8A2  PDE3B2  PDE4A2  
    9 SIMAP similar genes for PDE7B using alignment to 4 protein entries:     PDE7B_HUMAN (see all proteins):
    PDE7B variant protein    PDE7A    PDE7    PDE4    PDE4B    PDE4B5
    PDE4D    PDE4C    PDE8A

    PDE7B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6060 SNPs in PDE7B are shown (see all 6060)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58802661,2
    C--133751030(+) GGCAT-/TG    
       
    /TGTG
    TGTGT
    1 -- int10--------
    rs1444691081,2
    C--133757339(+) TGTAT-/AC    
       
    /CACA
    ACACA
    1 -- int10--------
    rs1834481941,2
    --133757362(+) ACACAC/TATATA 1 -- int10--------
    rs557778021,2
    C--133782854(+) GTGTG-/TGGGTAT 1 -- int11Minor allele frequency- TG:0.00NA 2
    rs710067771,2
    C--133800221(-) ATTAGC/-CGGGC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs45668971,2
    C,A--133834499(+) atagaC/Tagaca 1 -- int10--------
    rs1386385591,2
    C--133837030(+) AAAAC-/AGAGTTT 1 -- int10--------
    rs1857622161,2
    --133917360(+) AAAAAA/CAAAAA 1 -- int10--------
    rs1923272221,2
    --133917361(+) AAAAAA/CAAAAA 1 -- int10--------
    rs2008265921,2
    C--133965322(+) GAAGAA/CAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PDE7B (136172834 - 136422834 bp, first 250kb of PDE7B)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for PDE7B (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667637CNV Deletion23128226
    esv2657421CNV Deletion23128226
    esv2732744CNV Deletion23290073
    esv2732745CNV Deletion23290073
    esv2263540CNV Deletion18987734
    esv2530297CNV Deletion19546169
    esv2919CNV Deletion18987735
    esv1491990CNV Insertion17803354
    esv274646CNV Insertion20981092
    esv268004CNV Insertion20981092


    Human Gene Mutation Database (HGMD): PDE7B

    Locus Specific Mutation Databases (LSDB): PDE7B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PDE7B
    DNA2.0 Custom Variant and Variant Library Synthesis for PDE7B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604645    OMIM disorders: --

    7 diseases for PDE7B:    About MalaCards
    dyslexia    mantle cell lymphoma    osteosarcoma    chronic lymphocytic leukemia
    schizophrenia    alzheimer's disease    leukemia


    PDE7B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PDE7B
    Human Genome Epidemiology (HuGE) Navigator: PDE7B (8 documents)

    Export disorders for PDE7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDE7B gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with PDE7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human PDE7B, a cAMP-specific phosphodiesterase. (PubMed id 10814504)1, 2, 9 Sasaki T.... Omori K. (2000)
    2. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. (PubMed id 10618442)1, 3, 9 Hetman J.M....Beavo J.A. (2000)
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (2010)
    4. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase. (PubMed id 10872825)1, 2 Gardner C.E.... Fidock M.D. (2000)
    8. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. (PubMed id 19033455)1, 9 Zhang L....Insel P.A. (2008)
    9. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (2013)
    10. High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma. (PubMed id 23453122)1 Fang C....Li J.Y. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27115 HGNC: 8792 AceView: PDE7B Ensembl:ENSG00000171408 euGenes: HUgn27115
    ECgene: PDE7B Kegg: 27115 H-InvDB: PDE7B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDE7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDE7B gene:
    Search GeneIP for patents involving PDE7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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