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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDE7B Gene

protein-coding GIFtS: 59
GCID: GC06P136214

phosphodiesterase 7B

Explore 8 diseases affiliated with
PDE7B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphodiesterase 7B¹ ²		High-Affinity CAMP-Specific 3',5'-Cyclic Phosphodiesterase²
EC 3.1.4.17³ ⁸		Rolipram-Insensitive Phosphodiesterase Type 7²
BA472E5.1¹		EC 3.1.4⁸
CAMP-Specific 3',5'-Cyclic Phosphodiesterase 7B²

External Ids:	HGNC: 8792¹	Entrez Gene: 27115²	Ensembl: ENSG00000171408⁷	OMIM: 604645⁵	UniProtKB: Q9NP56³

Export aliases for PDE7B gene to outside databases

Previous GC identifers: GC06P135795 GC06P136019 GC06P136153 GC06P133737

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE7B:

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction

pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the

corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a

cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.(provided by RefSeq, Apr

2009)

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56

Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May

be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDE7B gene promoter:
POU2F1 POU2F1a Chx10 Cart-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDE7B promoter sequence

Search SABiosciences Chromatin IP Primers for PDE7B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE7B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24 Ensembl cytogenetic band: 6q23.3 HGNC cytogenetic band: 6q23-q24

PDE7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE7B gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P136214: view genomic region (about GC identifiers)

Start:	136,172,834 bp from pter	End:	136,516,712 bp from pter
Size:	343,879 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56 (See protein sequence)

Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B

Size: 450 amino acids; 51835 Da

Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a

preference for magnesium and/or manganese ions (By similarity)

1 PDB 3D structure from and Proteopedia for PDE7B:

1LXW (3D)

Secondary accessions: Q5W154

Explore the universe of human proteins at neXtProt for PDE7B: NX_Q9NP56

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NP56

4/7 DME Specific Peptides for PDE7B (Q9NP56) (see all 7)

HAADVTQ

HDVDHPG

SVLENHH

RLLSFQRY

PDE7B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061818.1

ENSEMBL proteins:

ENSP00000310661 ENSP00000403732

Reactome Protein details: Q9NP56
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PDE7B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

PDE7B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PDE7B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDE7B for domains About GeneDecksing

4 InterPro domains/families:

IPR002073 PDEase_catalytic_dom

IPR023174 PDEase_CS

IPR023088 PDEase

IPR003607 HD/PDEase_dom

Graphical View of Domain Structure for InterPro Entry Q9NP56

ProtoNet protein and cluster: Q9NP56

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56

Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal

regulatory domain

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56

Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May

be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

Enzyme regulation: Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone

Enzyme Numbers (IUBMB): EC 3.1.4.17¹ ² EC 3.1.4²

miRNA Products:		OriGene 3'-UTR Clone: PDE7B Browse MicroRNA Expression Plasmids
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		hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-128 hsa-miR-374a hsa-miR-3142 hsa-miR-200b hsa-miR-192*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for PDE7B

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PDE7B
		Search LifeMap BioReagents cell lines for PDE7B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE7B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

PDE7B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PDE7B:

Increased S DNA content

Upregulation of Wnt/beta-caten

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G Protein Signaling Pathways

G Protein Signaling Pathways

1.00

Purine metabolism

Purine metabolism

1.00

G beta:gamma signalling through PLC beta

G alpha (s) signalling events

0.14

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for PDE7B

G Protein Signaling Pathways

4 Reactome Pathways for PDE7B

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (s) signalling events

1 Kegg Pathway (Kegg details for PDE7B):

Purine metabolism

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56

Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1

PDE7B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PDE7B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/54 Interacting proteins for PDE7B (ENSP00000310661⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY3	ENSP00000260600⁴	STRING: ENSP00000260600
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006198	cAMP catabolic process	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007268	synaptic transmission	TAS	10814504

PDE7B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PDE7B for compounds About GeneDecksing

EMD Millipore small molecules for PDE7B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PDE7B

5 HMDB Compounds for PDE7B About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 DrugBank Compounds for PDE7B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dyphylline	Dihydroxypropyl Theophylline (see all 8)	479-18-5	target	inhibitor	17139284 17016423
Ketotifen	Ketotifen Fumarate (see all 5)	34580-14-8	target	inhibitor	17139284 17016423

2 Novoseek chemical compound relationships for PDE7B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sch51866	98.2	1	10814504 (1)
dipyridamole	59.6	1	10814504 (1)

Search CenterWatch for drugs/clinical trials and news about PDE7B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDE7B gene:

NM_018945.3

Unigene Cluster for PDE7B:

Phosphodiesterase 7B

Hs.744230 [show with all ESTs]

Unigene Representative Sequence: AB209990

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308191(uc003qgp.3 uc003qgr.3) ENST00000446774

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE7B
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		hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-128 hsa-miR-374a hsa-miR-3142 hsa-miR-200b hsa-miR-192*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE7B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE7B

Additional cDNA sequence:

AB038040.1 AB209990.1 AF086025.1 AJ251860.1 AK290582.1 BC070267.1 BC075082.2 BC075083.2

EF108327.1

6 DOTS entries:

DT.423433 DT.100653870 DT.408060 DT.100646287 DT.40128101 DT.100736387

24/59 AceView cDNA sequences (see all 59):

CF552286 CD677756 H88677 AI431726 BM726183 BC075082 AW271704 N69957

BC075083 CF125595 BX118073 AF086025 BX095790 CF125521 AW138785 BF939312

BX480641 BX641430 AI961166 AI953675 NM_018945 BM682610 BF700253 AA099585

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDE7B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCATCAAT

About this image

PDE7B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PDE7B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE7B

SOURCE GeneReport for Unigene cluster: Hs.744230

UniProtKB/Swiss-Prot: PDE7B_HUMAN, Q9NP56

Tissue specificity: Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas

SABiosciences Custom PCR Arrays for PDE7B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE7B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PDE7B gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PDE7B¹	phosphodiesterase 7B	81.09(n) 87.26(a)		421692 XM_419729.3 XP_419729.3
lizard (Anolis carolinensis)	Reptilia	PDE7B⁶	--	85(a)	1 ↔ 1	GL343200.1(2541887-2586266)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX741394.1²	--	76.52(n)		BX741394.1
honey bee (Apis mellifera)	Insecta	--	--	16(a)	1 → many	GroupUn.9(21103-31865)

ENSEMBL Gene Tree for PDE7B (if available)
TreeFam Gene Tree for PDE7B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PDE7B gene

PDE4D² PDE3A² PDE8B² PDE4B² PDE4C² PDE1B² PDE1A² PDE9A²

PDE1C² PDE7A² PDE8A² PDE4A² PDE3B²

9 SIMAP similar genes for PDE7B using alignment to 4 protein entries: PDE7B_HUMAN (see all proteins):

PDE7B variant protein PDE7A PDE7 PDE4 PDE4B PDE4B5

PDE4D PDE4C PDE8A

PDE7B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78326630^1,2	F,	--	133735355(+)	`CTCTTC/TAGAAT`	1	--	us2k¹		1		WA	118
rs201313789^1,2	C	--	133735520(+)	`TCTCTC/TCCAGC`	1	--	us2k¹		0	--	--	--	--
rs61406554^1,2	C,F,	--	133735647(+)	`TTCGGG/ACCTCC`	1	--	us2k¹		3		WA CSA	122
rs115844934^1,2	C,F,	--	133736335(+)	`GGTAAA/GGGAAG`	1	--	us2k¹		1		WA	118
rs9483883^1,2	C,F,H,	--	133736580(+)	`ACCAGT/AGCATT`	1	--	us2k¹		8		NS EA NA WA CSA	544
rs1418342^1,2	C,F,H,	--	133736646(-)	`ATTTTT/CACTCT`	1	--	us2k¹		3		MN NS	590
rs77932410^1,2	F,	--	133736773(+)	`TTTTTG/ATTTTG`	1	--	us2k¹		1		WA	118
rs80168940^1,2		--	133736854(+)	`AAATGC/TTTCTT`	1	--	us2k¹		0	--	--	--	--
rs201734694^1,2	C	--	133737296(-)	`AGTAAA/CAAAAA`	1	--	ut5¹		0	--	--	--	--
rs77580358^1,2	F,	--	133738365(+)	`AAATGC/TTGCAG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for PDE7B (136172834 - 136422834 bp, first 250kb of PDE7B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for PDE7B
4 CNVs: 10167 2655 99722 94040
3 Indels: 62578 42082 47002
Human Gene Mutation Database (HGMD): PDE7B

Locus Specific Mutation Databases (LSDB): PDE7B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDE7B

DNA2.0 Custom Variant and Variant Library Synthesis for PDE7B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PDE7B for disorders           About GeneDecksing

OMIM gene information: 604645    OMIM disorders: --

8 diseases for PDE7B:    About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia dyslexia alzheimer's disease

leukemia osteosarcoma schizophrenia malaria

Human Genome Epidemiology (HuGE) Navigator: PDE7B (8 documents)

Export disorders for PDE7B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PDE7B gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with PDE7B)

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Identification of human PDE7B, a cAMP-specific phosphodiesterase. (PubMed id 10814504)^{1, 2, 9} Sasaki T.... Omori K. (2000)
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. (PubMed id 10618442)^{1, 3, 9} Hetman J.M....Beavo J.A. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase. (PubMed id 10872825)^{1, 2} Gardner C.E.... Fidock M.D. (2000)
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. (PubMed id 19033455)^{1, 9} Zhang L....Insel P.A. (2008)
[Expression of cyclic nucleotide phosphodiesterase 7B in patients with mantle cell lymphoma and its prognostic significance]. (PubMed id 21362230)¹ Dong H.J....Li J.Y. (2011)
A cohort of balanced reciprocal translocations associ ated with dyslexia: identification of two putative candidate genes at DYX1. (PubMed id 20798984)¹ Buonincontri R....Tommerup N. (2011)
Bioavailability of testosterone enanthate dependent o n genetic variation in the phosphodiesterase 7B but not on the uridine 5'-dipho spho-glucuronosyltransferase (UGT2B17) gene. (PubMed id 21383644)¹ EkstrAPm L....Rane A. (2011)
Genetic variation in phosphodiesterase (PDE) 7B in chr onic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDE s in human disease. (PubMed id 21796143)¹ Peiro A.M....Insel P.A. (2011)
Cyclic nucleotide phosphodiesterase 7B mRNA: an unfav orable characteristic in chronic lymphocytic leukemia. (PubMed id 21120911)¹ Zhang L....Insel P.A. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27115	HGNC: 8792	AceView: PDE7B	Ensembl:ENSG00000171408	euGenes: HUgn27115
ECgene: PDE7B	Kegg: 27115	H-InvDB: PDE7B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for PDE7B	Pharmacogenomics, SNPs, Pathways

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Patent Information for PDE7B gene:
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