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Aliases for PDE7B Gene

Aliases for PDE7B Gene

  • Phosphodiesterase 7B 2 3
  • High-Affinity CAMP-Specific 3,5-Cyclic Phosphodiesterase 3
  • Rolipram-Insensitive Phosphodiesterase Type 7 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4
  • BA472E5.1 3
  • EC 3.1.4 63

External Ids for PDE7B Gene

Previous GeneCards Identifiers for PDE7B Gene

  • GC06P136019
  • GC06P136153
  • GC06P136214
  • GC06P133737

Summaries for PDE7B Gene

Entrez Gene Summary for PDE7B Gene

  • The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

GeneCards Summary for PDE7B Gene

PDE7B (Phosphodiesterase 7B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G Protein Signaling Pathways. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE7B Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE7B Gene

Genomics for PDE7B Gene

Regulatory Elements for PDE7B Gene

Genomic Location for PDE7B Gene

Chromosome:
6
Start:
135,808,752 bp from pter
End:
136,195,574 bp from pter
Size:
386,823 bases
Orientation:
Plus strand

Genomic View for PDE7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE7B Gene

Proteins for PDE7B Gene

  • Protein details for PDE7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP56-PDE7B_HUMAN
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 7B
    Protein Accession:
    Q9NP56
    Secondary Accessions:
    • Q5W154

    Protein attributes for PDE7B Gene

    Size:
    450 amino acids
    Molecular mass:
    51835 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDE7B Gene

neXtProt entry for PDE7B Gene

Proteomics data for PDE7B Gene at MOPED

Selected DME Specific Peptides for PDE7B Gene

Post-translational modifications for PDE7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE7B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PDE7B

Domains & Families for PDE7B Gene

Gene Families for PDE7B Gene

Protein Domains for PDE7B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP56

UniProtKB/Swiss-Prot:

PDE7B_HUMAN :
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
genes like me logo Genes that share domains with PDE7B: view

Function for PDE7B Gene

Molecular function for PDE7B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

Enzyme Numbers (IUBMB) for PDE7B Gene

Gene Ontology (GO) - Molecular Function for PDE7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IEA --
GO:0008081 phosphoric diester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE7B: view
genes like me logo Genes that share phenotypes with PDE7B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE7B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PDE7B Gene

Localization for PDE7B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE7B Gene COMPARTMENTS Subcellular localization image for PDE7B gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PDE7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE7B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE7B Gene

Pathways & Interactions for PDE7B Gene

genes like me logo Genes that share pathways with PDE7B: view

Pathways by source for PDE7B Gene

2 KEGG pathways for PDE7B Gene

UniProtKB/Swiss-Prot Q9NP56-PDE7B_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

Interacting Proteins for PDE7B Gene

Gene Ontology (GO) - Biological Process for PDE7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007268 synaptic transmission TAS 10814504
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with PDE7B: view

No data available for SIGNOR curated interactions for PDE7B Gene

Drugs & Compounds for PDE7B Gene

(10) Drugs for PDE7B Gene - From: HMDB, DGIdb, DrugBank, IUPHAR, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Dipyridamole Approved Pharma Inhibition, Inhibitor, inhibitor Adenosine transport inhibitor 75
Ketotifen Approved Pharma Target, inhibitor 20
Caffeine Approved Nutra Activator, Target, inhibitor, competitive 317
Adenosine monophosphate Approved Nutra 0

(1) Additional Compounds for PDE7B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PDE7B: view

Transcripts for PDE7B Gene

Unigene Clusters for PDE7B Gene

Phosphodiesterase 7B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE7B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE7B Gene

No ASD Table

Relevant External Links for PDE7B Gene

GeneLoc Exon Structure for
PDE7B
ECgene alternative splicing isoforms for
PDE7B

Expression for PDE7B Gene

mRNA expression in normal human tissues for PDE7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE7B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Putamen (basal ganglia) (x4.6), and Brain - Caudate (basal ganglia) (x4.4).

SOURCE GeneReport for Unigene cluster for PDE7B Gene Hs.744230

mRNA Expression by UniProt/SwissProt for PDE7B Gene

Q9NP56-PDE7B_HUMAN
Tissue specificity: Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas
genes like me logo Genes that share expression patterns with PDE7B: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PDE7B Gene

Orthologs for PDE7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDE7B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE7B 35
  • 94.27 (n)
  • 96.9 (a)
PDE7B 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE7B 35
  • 92.51 (n)
  • 92.67 (a)
PDE7B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde7b 35
  • 89.96 (n)
  • 92.81 (a)
Pde7b 16
Pde7b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE7B 35
  • 99.45 (n)
  • 99.29 (a)
PDE7B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde7b 35
  • 88.99 (n)
  • 91.91 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE7B 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE7B 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE7B 35
  • 80.92 (n)
  • 86.7 (a)
PDE7B 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE7B 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde7b 35
  • 77.07 (n)
  • 84.62 (a)
zebrafish
(Danio rerio)
Actinopterygii CR848033.1 36
  • 18 (a)
ManyToMany
Species with no ortholog for PDE7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE7B Gene

ENSEMBL:
Gene Tree for PDE7B (if available)
TreeFam:
Gene Tree for PDE7B (if available)

Paralogs for PDE7B Gene

Paralogs for PDE7B Gene

(8) SIMAP similar genes for PDE7B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PDE7B: view

Variants for PDE7B Gene

Sequence variations from dbSNP and Humsavar for PDE7B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs471098 -- 136,131,551(+) CCACT(C/T)TTTCC intron-variant
rs487278 -- 136,180,690(+) TGTGA(A/G)GCAAG intron-variant
rs494077 -- 136,131,698(+) AGTGA(A/G)ACATG intron-variant
rs494179 -- 136,131,729(+) ACAAG(G/T)GATTA intron-variant
rs494908 -- 136,131,767(+) TTTAG(G/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE7B Gene

Variant ID Type Subtype PubMed ID
nsv830816 CNV Gain 17160897
esv2530297 CNV Deletion 19546169
esv2263540 CNV Deletion 18987734
esv2919 CNV Deletion 18987735
esv2732744 CNV Deletion 23290073
esv8107 CNV Loss 19470904
esv2657421 CNV Deletion 23128226
esv2732745 CNV Deletion 23290073
esv2667637 CNV Deletion 23128226
dgv2011e1 CNV Complex 17122850
nsv818458 CNV Loss 17921354
esv268004 CNV Insertion 20981092
esv274646 CNV Insertion 20981092
esv1491990 CNV Insertion 17803354
nsv526684 CNV Loss 19592680

Variation tolerance for PDE7B Gene

Residual Variation Intolerance Score: 44.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE7B Gene

HapMap Linkage Disequilibrium report
PDE7B
Human Gene Mutation Database (HGMD)
PDE7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE7B Gene

Disorders for PDE7B Gene

Relevant External Links for PDE7B

Genetic Association Database (GAD)
PDE7B
Human Genome Epidemiology (HuGE) Navigator
PDE7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE7B
genes like me logo Genes that share disorders with PDE7B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE7B Gene

Publications for PDE7B Gene

  1. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. (PMID: 10618442) Hetman J.M. … Beavo J.A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 23 67
  2. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. (PMID: 19033455) Zhang L. … Insel P.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 23 67
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. (PMID: 15627479) AhlstrAPm M. … Lamberg-Allardt C. (Biochem. Pharmacol. 2005) 23 67

Products for PDE7B Gene

Sources for PDE7B Gene

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