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Aliases for PDE7A Gene

Aliases for PDE7A Gene

  • Phosphodiesterase 7A 2 3
  • HCP1 3 4
  • TM22 3 4
  • Phosphodiesterase Isozyme 7 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4
  • EC 3.1.4 63
  • PDE7 3

External Ids for PDE7A Gene

Previous GeneCards Identifiers for PDE7A Gene

  • GC08P065764
  • GC08M066569
  • GC08M066354
  • GC08M066681
  • GC08M066793
  • GC08M062120
  • GC08M066629

Summaries for PDE7A Gene

Entrez Gene Summary for PDE7A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for PDE7A Gene

PDE7A (Phosphodiesterase 7A) is a Protein Coding gene. Diseases associated with PDE7A include chronic lymphocytic leukemia. Among its related pathways are Signaling by GPCR and G Protein Signaling Pathways. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE1A.

UniProtKB/Swiss-Prot for PDE7A Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Tocris Summary for PDE7A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE7A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE7A Gene

Genomics for PDE7A Gene

Regulatory Elements for PDE7A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE7A Gene

Chromosome:
8
Start:
65,714,334 bp from pter
End:
65,842,322 bp from pter
Size:
127,989 bases
Orientation:
Minus strand

Genomic View for PDE7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PDE7A Gene

Proteins for PDE7A Gene

  • Protein details for PDE7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13946-PDE7A_HUMAN
    Recommended name:
    High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A
    Protein Accession:
    Q13946
    Secondary Accessions:
    • A0AVH6
    • A8K436
    • A8K9G5
    • O15380
    • Q96T72

    Protein attributes for PDE7A Gene

    Size:
    482 amino acids
    Molecular mass:
    55505 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Interacts with CBFA2T3.

    Three dimensional structures from OCA and Proteopedia for PDE7A Gene

    Alternative splice isoforms for PDE7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE7A Gene

Proteomics data for PDE7A Gene at MOPED

Selected DME Specific Peptides for PDE7A Gene

Post-translational modifications for PDE7A Gene

  • Ubiquitination at Lys 448
  • Modification sites at PhosphoSitePlus

Other Protein References for PDE7A Gene

Domains & Families for PDE7A Gene

Gene Families for PDE7A Gene

Protein Domains for PDE7A Gene

Suggested Antigen Peptide Sequences for PDE7A Gene

Graphical View of Domain Structure for InterPro Entry

Q13946

UniProtKB/Swiss-Prot:

PDE7A_HUMAN :
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
genes like me logo Genes that share domains with PDE7A: view

Function for PDE7A Gene

Molecular function for PDE7A Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class VII,A,high affinity with two alternatively spliced forms PDE7A1 and PDE7A2 expressed in skeletal muscle,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Insensitive to all selective PDE inhibitors
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Enzyme Numbers (IUBMB) for PDE7A Gene

Gene Ontology (GO) - Molecular Function for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004112 cyclic-nucleotide phosphodiesterase activity --
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS 8389765
GO:0008081 phosphoric diester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE7A: view

Phenotypes for PDE7A Gene

genes like me logo Genes that share phenotypes with PDE7A: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE7A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PDE7A Gene

Localization for PDE7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE7A Gene

Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE7A Gene COMPARTMENTS Subcellular localization image for PDE7A gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE7A: view

Pathways & Interactions for PDE7A Gene

genes like me logo Genes that share pathways with PDE7A: view

Pathways by source for PDE7A Gene

2 KEGG pathways for PDE7A Gene

UniProtKB/Swiss-Prot Q13946-PDE7A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

Interacting Proteins for PDE7A Gene

Gene Ontology (GO) - Biological Process for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction --
GO:0019933 cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with PDE7A: view

No data available for SIGNOR curated interactions for PDE7A Gene

Drugs & Compounds for PDE7A Gene

(16) Drugs for PDE7A Gene - From: HMDB, IUPHAR, DGIdb, NovoSeek, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Ketotifen Approved Pharma Target, inhibitor 20
Caffeine Approved Nutra Activator, Target, inhibitor, competitive 317
Adenosine monophosphate Approved Nutra 0
Cilostazol Approved Pharma PDE3 inhibitor, PDE3A inhibitor. Also adenosine uptake inhibitor 98

(6) Additional Compounds for PDE7A Gene - From: HMDB, NovoSeek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MY-5445
78351-75-4
Ro 20-1724
29925-17-5
IBMX
Antagonist
genes like me logo Genes that share compounds with PDE7A: view

Transcripts for PDE7A Gene

Unigene Clusters for PDE7A Gene

Phosphodiesterase 7A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE7A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE7A Gene

No ASD Table

Relevant External Links for PDE7A Gene

GeneLoc Exon Structure for
PDE7A
ECgene alternative splicing isoforms for
PDE7A

Expression for PDE7A Gene

mRNA expression in normal human tissues for PDE7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE7A Gene

This gene is overexpressed in Muscle - Skeletal (x5.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for PDE7A Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE7A Gene



SOURCE GeneReport for Unigene cluster for PDE7A Gene Hs.527119

mRNA Expression by UniProt/SwissProt for PDE7A Gene

Q13946-PDE7A_HUMAN
Tissue specificity: PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart
genes like me logo Genes that share expression patterns with PDE7A: view

Protein tissue co-expression partners for PDE7A Gene

Primer Products

In Situ Assay Products

Orthologs for PDE7A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE7A 35
  • 92.45 (n)
  • 97.3 (a)
PDE7A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE7A 35
  • 94.75 (n)
  • 97.03 (a)
PDE7A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde7a 35
  • 90.66 (n)
  • 94.19 (a)
Pde7a 16
Pde7a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE7A 35
  • 99.72 (n)
  • 100 (a)
PDE7A 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde7a 35
  • 90.8 (n)
  • 94.81 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE7A 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE7A 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE7A 35
  • 83.49 (n)
  • 89.95 (a)
PDE7A 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE7A 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde7a 35
  • 78.64 (n)
  • 86.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32174 35
zebrafish
(Danio rerio)
Actinopterygii pde7a 35
  • 70.89 (n)
  • 78.97 (a)
pde7a 35
pde7a 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005536 35
  • 51.56 (n)
  • 48.9 (a)
Species with no ortholog for PDE7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE7A Gene

ENSEMBL:
Gene Tree for PDE7A (if available)
TreeFam:
Gene Tree for PDE7A (if available)

Paralogs for PDE7A Gene

Paralogs for PDE7A Gene

(6) SIMAP similar genes for PDE7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PDE7A Gene

genes like me logo Genes that share paralogs with PDE7A: view

Variants for PDE7A Gene

Sequence variations from dbSNP and Humsavar for PDE7A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs972362 -- 65,779,699(+) GAAAC(A/T)TCATG intron-variant
rs974149 -- 65,778,587(+) TGGTT(A/G)TTTTA intron-variant
rs1316700 -- 65,781,884(+) AAAGG(A/C)TGCAC intron-variant
rs1398909 -- 65,793,680(+) AATGT(C/G)GACAG intron-variant
rs1513723 -- 65,791,553(+) CCTCC(C/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE7A Gene

Variant ID Type Subtype PubMed ID
nsv395879 CNV Loss 16902084
nsv395873 CNV Loss 16902084
dgv247n6 CNV Loss 16902084
dgv248n6 CNV Loss 16902084
nsv395795 CNV Loss 16902084
nsv395893 CNV Loss 16902084
nsv6233 CNV Insertion 18451855

Variation tolerance for PDE7A Gene

Residual Variation Intolerance Score: 11.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE7A Gene

HapMap Linkage Disequilibrium report
PDE7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE7A Gene

Disorders for PDE7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE7A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • lymphoplasmacytic leukemia
- elite association
Search PDE7A in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE7A

Genetic Association Database (GAD)
PDE7A
Human Genome Epidemiology (HuGE) Navigator
PDE7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE7A
genes like me logo Genes that share disorders with PDE7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE7A Gene

Publications for PDE7A Gene

  1. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase- deficient Saccharomyces cerevisiae. (PMID: 8389765) Michaeli T. … Wigler M. (J. Biol. Chem. 1993) 2 23 67
  2. Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells. (PMID: 19737543) Dong H. … Epstein P.M. (Biochem. Pharmacol. 2010) 23 67
  3. Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo. (PMID: 20132810) Goto M. … Fukuda Y. (Eur. J. Pharmacol. 2010) 23 67
  4. ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes. (PMID: 19195485) Kadoshima-Yamaoka K. … Nishimura T. (Immunol. Lett. 2009) 23 67
  5. Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation. (PMID: 19272774) Guo J. … Pitts W.J. (Bioorg. Med. Chem. Lett. 2009) 23 67

Products for PDE7A Gene

Sources for PDE7A Gene

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