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Aliases for PDE7A Gene

Aliases for PDE7A Gene

  • Phosphodiesterase 7A 2 3 5
  • HCP1 3 4
  • TM22 3 4
  • High Affinity CAMP-Specific 3,5-Cyclic Phosphodiesterase 7A 3
  • Phosphodiesterase Isozyme 7 3
  • EC 3.1.4.17 61
  • EC 3.1.4.53 4
  • EC 3.1.4 61
  • PDE7 3

External Ids for PDE7A Gene

Previous GeneCards Identifiers for PDE7A Gene

  • GC08P065764
  • GC08M066569
  • GC08M066354
  • GC08M066681
  • GC08M066793
  • GC08M062120
  • GC08M066629

Summaries for PDE7A Gene

Entrez Gene Summary for PDE7A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for PDE7A Gene

PDE7A (Phosphodiesterase 7A) is a Protein Coding gene. Diseases associated with PDE7A include Chronic Lymphocytic Leukemia. Among its related pathways are Signaling by GPCR and Purine metabolism (KEGG). GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7B.

UniProtKB/Swiss-Prot for PDE7A Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Tocris Summary for PDE7A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE7A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE7A Gene

Genomics for PDE7A Gene

Regulatory Elements for PDE7A Gene

Enhancers for PDE7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F065943 1.7 FANTOM5 Ensembl ENCODE 18.9 -108.0 -107979 14.2 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 GATA2 ZNF143 FOS DEK SP3 PDE7A MTFR1 C8orf44 DNAJC5B LINC01299 ENSG00000272010 RRS1 GC08P065965 GC08M065874
GH08F065980 1.5 FANTOM5 Ensembl ENCODE 17.5 -139.8 -139784 4.1 TBP PKNOX1 TBL1XR1 BMI1 ZNF766 CBX5 SCRT2 ZNF143 ZNF207 ETV6 PDE7A DNAJC5B MTFR1 LINC01299 GC08M065983 GC08P065965
GH08F065877 1.5 FANTOM5 Ensembl ENCODE 17.4 -36.8 -36845 3.3 HDGF TBP TBL1XR1 ARID4B RFX5 CBX5 RCOR1 CREM ZNF263 MXD4 PDE7A MTFR1 LINC01299 GC08M065874 GC08P065965
GH08F066021 1.6 FANTOM5 Ensembl ENCODE 16 -180.0 -179961 2.3 PKNOX1 RAD21 GLIS2 ZNF366 SCRT2 FOS ZNF263 SMARCC1 SP5 CEBPB PDE7A MTFR1 ADHFE1 RRS1 RRS1-AS1 LOC105375883 GC08M066012
GH08F066026 1.2 Ensembl ENCODE 16.6 -186.1 -186147 4.4 PKNOX1 SIN3A FEZF1 ZNF207 FOS DEK SMARCB1 MBD2 GLIS1 STAT3 PDE7A MTFR1 ADHFE1 RRS1 RRS1-AS1 ENSG00000272010 LOC105375883 GC08M066089
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDE7A on UCSC Golden Path with GeneCards custom track

Genomic Location for PDE7A Gene

Chromosome:
8
Start:
65,714,334 bp from pter
End:
65,842,322 bp from pter
Size:
127,989 bases
Orientation:
Minus strand

Genomic View for PDE7A Gene

Genes around PDE7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE7A Gene

Proteins for PDE7A Gene

  • Protein details for PDE7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13946-PDE7A_HUMAN
    Recommended name:
    High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A
    Protein Accession:
    Q13946
    Secondary Accessions:
    • A0AVH6
    • A8K436
    • A8K9G5
    • O15380
    • Q96T72

    Protein attributes for PDE7A Gene

    Size:
    482 amino acids
    Molecular mass:
    55505 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Interacts with CBFA2T3.

    Three dimensional structures from OCA and Proteopedia for PDE7A Gene

    Alternative splice isoforms for PDE7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE7A Gene

Selected DME Specific Peptides for PDE7A Gene

Q13946:
  • HAADVTQ
  • SVLENHH
  • FDIFLFDRLTNGNSLV
  • ALKCADICNPCR
  • DHPGVNQPFLIKTNH
  • RLLSFQRY

Post-translational modifications for PDE7A Gene

  • Ubiquitination at Lys 448
  • Modification sites at PhosphoSitePlus

Other Protein References for PDE7A Gene

Domains & Families for PDE7A Gene

Gene Families for PDE7A Gene

Protein Domains for PDE7A Gene

Suggested Antigen Peptide Sequences for PDE7A Gene

Graphical View of Domain Structure for InterPro Entry

Q13946

UniProtKB/Swiss-Prot:

PDE7A_HUMAN :
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
genes like me logo Genes that share domains with PDE7A: view

Function for PDE7A Gene

Molecular function for PDE7A Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class VII,A,high affinity with two alternatively spliced forms PDE7A1 and PDE7A2 expressed in skeletal muscle,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Insensitive to all selective PDE inhibitors.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Enzyme Numbers (IUBMB) for PDE7A Gene

Gene Ontology (GO) - Molecular Function for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IDA,TAS 8389765
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE7A: view
genes like me logo Genes that share phenotypes with PDE7A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE7A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE7A Gene

Localization for PDE7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE7A Gene

Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE7A gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE7A: view

Pathways & Interactions for PDE7A Gene

genes like me logo Genes that share pathways with PDE7A: view

Pathways by source for PDE7A Gene

2 KEGG pathways for PDE7A Gene

UniProtKB/Swiss-Prot Q13946-PDE7A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

Gene Ontology (GO) - Biological Process for PDE7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with PDE7A: view

No data available for SIGNOR curated interactions for PDE7A Gene

Drugs & Compounds for PDE7A Gene

(21) Drugs for PDE7A Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Ketotifen Approved Pharma Target, inhibitor 22
Caffeine Approved Nutra Antagonist, Target, inhibitor, competitive A1 and A2B antagonist. CNS stimulant 380
Cafcit Injection Approved September 1999 Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for PDE7A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IBMX
Antagonist 28822-58-4

(5) Tocris Compounds for PDE7A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) 85416-75-7
IBMX PDE inhibitor (non-selective) 28822-58-4
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
Rolipram PDE4 inhibitor 61413-54-5
Sildenafil citrate Orally active, potent PDE5 inhibitor 171599-83-0

(1) ApexBio Compounds for PDE7A Gene

Compound Action Cas Number
BRL 50481 PDE7 inhibitor,potent and selective
genes like me logo Genes that share compounds with PDE7A: view

Transcripts for PDE7A Gene

Unigene Clusters for PDE7A Gene

Phosphodiesterase 7A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE7A Gene

No ASD Table

Relevant External Links for PDE7A Gene

GeneLoc Exon Structure for
PDE7A
ECgene alternative splicing isoforms for
PDE7A

Expression for PDE7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDE7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE7A Gene

This gene is overexpressed in Muscle - Skeletal (x5.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for PDE7A Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDE7A Gene



Protein tissue co-expression partners for PDE7A Gene

NURSA nuclear receptor signaling pathways regulating expression of PDE7A Gene:

PDE7A

SOURCE GeneReport for Unigene cluster for PDE7A Gene:

Hs.527119

mRNA Expression by UniProt/SwissProt for PDE7A Gene:

Q13946-PDE7A_HUMAN
Tissue specificity: PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
genes like me logo Genes that share expression patterns with PDE7A: view

Orthologs for PDE7A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE7A 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia PDE7A 34 35
  • 94.75 (n)
cow
(Bos Taurus)
Mammalia PDE7A 34 35
  • 92.45 (n)
rat
(Rattus norvegicus)
Mammalia Pde7a 34
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Pde7a 34 16 35
  • 90.66 (n)
oppossum
(Monodelphis domestica)
Mammalia PDE7A 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE7A 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE7A 34 35
  • 83.49 (n)
lizard
(Anolis carolinensis)
Reptilia PDE7A 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde7a 34
  • 78.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32174 34
zebrafish
(Danio rerio)
Actinopterygii pde7a 34 34 35
  • 70.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005536 34
  • 51.56 (n)
Species where no ortholog for PDE7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE7A Gene

ENSEMBL:
Gene Tree for PDE7A (if available)
TreeFam:
Gene Tree for PDE7A (if available)

Paralogs for PDE7A Gene

Paralogs for PDE7A Gene

(6) SIMAP similar genes for PDE7A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PDE7A Gene

genes like me logo Genes that share paralogs with PDE7A: view

Variants for PDE7A Gene

Sequence variations from dbSNP and Humsavar for PDE7A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088623 -- 65,749,902(+) TGAAG(A/G)TATGG intron-variant
rs10089128 -- 65,739,470(+) TAAAT(C/G)TTGTT intron-variant
rs10096256 -- 65,751,541(+) TTGCT(A/G)GAGTG intron-variant, downstream-variant-500B
rs10108045 -- 65,777,243(+) cctgg(C/G)taatt intron-variant
rs10110985 -- 65,732,956(+) CCATC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE7A Gene

Variant ID Type Subtype PubMed ID
dgv247n6 CNV deletion 16902084
dgv248n6 CNV deletion 16902084
esv3617471 CNV gain 21293372
nsv395795 CNV deletion 16902084
nsv395873 CNV deletion 16902084
nsv395879 CNV deletion 16902084
nsv395893 CNV deletion 16902084
nsv6233 CNV insertion 18451855

Variation tolerance for PDE7A Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDE7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE7A Gene

Disorders for PDE7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE7A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search PDE7A in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE7A

Genetic Association Database (GAD)
PDE7A
Human Genome Epidemiology (HuGE) Navigator
PDE7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE7A
genes like me logo Genes that share disorders with PDE7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE7A Gene

Publications for PDE7A Gene

  1. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase- deficient Saccharomyces cerevisiae. (PMID: 8389765) Michaeli T. … Wigler M. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. (PMID: 15994308) Wang H. … Ke H. (J. Biol. Chem. 2005) 3 4 22 64
  3. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. (PMID: 9195912) Han P. … Michaeli T. (J. Biol. Chem. 1997) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for PDE7A Gene

Sources for PDE7A Gene

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