Aliases for PDE6H Gene
Aliases for PDE6H Gene
External Ids for PDE6H Gene
- HGNC: 8790
- Entrez Gene: 5149
- Ensembl: ENSG00000139053
- OMIM: 601190
- UniProtKB: Q13956
Previous GeneCards Identifiers for PDE6H Gene
- GC12P014865
- GC12P015270
- GC12P015026
- GC12P015017
- GC12P015125
- GC12P014975
- GC12P014976
- GC12P014977
- GC12P014978
- GC12P014979
- GC12P014980
- GC12P014981
Summaries for PDE6H Gene
-
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
GeneCards Summary for PDE6H Gene
PDE6H (Phosphodiesterase 6H) is a Protein Coding gene. Diseases associated with PDE6H include Retinal Cone Dystrophy 3A and Achromatopsia. Among its related pathways are Pyrimidine metabolism (KEGG) and Phototransduction. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and cGMP binding. An important paralog of this gene is PDE6G.
UniProtKB/Swiss-Prot for PDE6H Gene
-
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
-
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.
Additional gene information for PDE6H Gene
- Monarch Initiative
- Search for PDE6H at DataMed
- Search for PDE6H at HumanCyc
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE6H Gene
Genomics for PDE6H Gene
GeneHancer (GH) Regulatory Elements for PDE6H Gene
Promoters and enhancers for PDE6H Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PDE6H on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PDE6H Gene
Genomic Locations for PDE6H Gene
- chr12:14,973,022-14,981,865
- (GRCh38/hg38)
- Size:
- 8,844 bases
- Orientation:
- Plus strand
- chr12:15,125,956-15,134,799
- (GRCh37/hg19)
Genomic View for PDE6H Gene
Genes around PDE6H on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.3 by Ensembl
- 12p12.3 by Entrez Gene
- 12p13 by HGNC
PDE6H Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PDE6H Gene
Proteins for PDE6H Gene
-
Protein details for PDE6H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13956-CNCG_HUMAN
- Recommended name:
- Retinal cone rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma
- Protein Accession:
- Q13956
- Q52LY7
Protein attributes for PDE6H Gene
- Size:
- 83 amino acids
- Molecular mass:
- 9074 Da
- Quaternary structure:
-
- Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).
Selected DME Specific Peptides for PDE6H Gene
- Q13956:
-
- TPRKGPPKFKQRQTRQFKSKPPKKGV
- HLELHELAQ
- GFGDDIPGMEGLGTDITVICPWEAF
Post-translational modifications for PDE6H Gene
No Post-translational modifications
Other Protein References for PDE6H Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for PDE6H
-
Santa Cruz Biotechnology (SCBT) Antibodies for PDE6H
Protein Products
-
OriGene Purified Proteins for PDE6H
- Search Origene for MassSpec and Protein Over-expression Lysates for PDE6H
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- ProSpec Recombinant Proteins for PDE6H
- Search GeneTex for Proteins for PDE6H
Assay Products
Domains & Families for PDE6H Gene
Gene Families for PDE6H Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for PDE6H Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PDE6H Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13956UniProtKB/Swiss-Prot:
CNCG_HUMAN :- The C-terminal region is important in conferring inhibition.
- Belongs to the rod/cone cGMP-PDE gamma subunit family.
- Domain:
-
- The C-terminal region is important in conferring inhibition.
- Family:
-
- Belongs to the rod/cone cGMP-PDE gamma subunit family.
Function for PDE6H Gene
Molecular function for PDE6H Gene
- GENATLAS Biochemistry:
- cGMP specific nucleotide phosphodiesterase,gamma subunit,cone phosphoreceptor
- UniProtKB/Swiss-Prot CatalyticActivity:
- Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate.
- UniProtKB/Swiss-Prot Function:
- Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Enzyme Numbers (IUBMB) for PDE6H Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004114 | 3,5-cyclic-nucleotide phosphodiesterase activity | IEA | -- |
| GO:0004857 | enzyme inhibitor activity | TAS | 8786098 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0030553 | cGMP binding | IEA | -- |
Phenotypes for PDE6H Gene
- MGI mutant phenotypes for PDE6H:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PDE6H:
Animal Models for PDE6H Gene
- MGI Knock Outs for PDE6H:
-
- Pde6h tm1.1Bewi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PDE6H gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDE6H gene
- Search ViGene Biosciences for PDE6H
CRISPR Products
-
OriGene CRISPR knockouts for PDE6H
- genomics-online: gRNA clones - Search results for 67 available PDE6H gene related products
- Overview of 67 available PDE6H gene related products
- Applied Biological Materials CRISPR for PDE6H
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDE6H
- GenScript: Design CRISPR guide RNA sequences for PDE6H
miRNA for PDE6H Gene
- miRTarBase miRNAs that target PDE6H
miRNA Products
- Search ViGene Biosciences for PDE6H
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDE6H
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- genomics-online: shRNA clones - Search results for 67 available PDE6H gene related products
- Overview of 67 available PDE6H gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDE6H gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PDE6H
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PDE6H
-
ViGene Biosciences adenoviral particle packaged cDNA for PDE6H gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PDE6H gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PDE6H gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PDE6H Gene
Localization for PDE6H Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PDE6H Gene
Pathways & Interactions for PDE6H Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Pyrimidine metabolism (KEGG) | ||
| 2 | Phototransduction | ||
Pathways by source for PDE6H Gene
1 BioSystems pathway for PDE6H Gene
1 KEGG pathway for PDE6H Gene
Interacting Proteins for PDE6H Gene
Selected Interacting proteins:
Q13956-CNCG_HUMAN
ENSP00000266395
for PDE6H Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0007601 | visual perception | TAS,IEA | -- |
| GO:0043086 | negative regulation of catalytic activity | IEA | -- |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | IEA | -- |
| GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for PDE6H Gene
Drugs & Compounds for PDE6H Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vardenafil | Approved | Pharma | Target, allosteric modulator | PDE5 inhibitor | 0 | |
| Sildenafil | Approved, Investigational | Pharma | Inhibition, Inhibitor, Target, inhibitor | PDE5 inhibitor, selective | 0 | |
| Water | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
| cyclic amp | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| IBMX |
|
Antagonist | 28822-58-4 |
|
|
(5) Tocris Compounds for PDE6H Gene
| Compound | Action | Cas Number |
|---|---|---|
| Eggmanone | Potent and selective PDE4 inhibitor; suppresses hedgehog signaling | 505068-32-6 |
| Etazolate hydrochloride | PDE4 inhibitor | 35838-58-5 |
| IBMX | PDE inhibitor (non-selective) | 28822-58-4 |
| MY-5445 | PDE5 inhibitor | 78351-75-4 |
| Ro 20-1724 | PDE4 inhibitor | 29925-17-5 |
Transcripts for PDE6H Gene
mRNA/cDNA for PDE6H Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (30) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PDE6H Gene
CRISPR Products
-
OriGene CRISPR knockouts for PDE6H
- genomics-online: gRNA clones - Search results for 67 available PDE6H gene related products
- Overview of 67 available PDE6H gene related products
- Applied Biological Materials CRISPR for PDE6H
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PDE6H
- GenScript: Design CRISPR guide RNA sequences for PDE6H
miRNA Products
- Search ViGene Biosciences for PDE6H
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PDE6H
- Browse OriGene Inhibitory RNA Products For PDE6H
- genomics-online: shRNA clones - Search results for 67 available PDE6H gene related products
- Overview of 67 available PDE6H gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PDE6H gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PDE6H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PDE6H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PDE6H
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PDE6H Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for PDE6H Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.7), Brain - Cortex (x6.8), Whole Blood (x6.0), and Brain - Anterior cingulate cortex (BA24) (x4.6).
NURSA nuclear receptor signaling pathways regulating expression of PDE6H Gene:
PDE6HSOURCE GeneReport for Unigene cluster for PDE6H Gene:
Hs.54471Evidence on tissue expression from TISSUES for PDE6H Gene
- Eye(4.5)
- Nervous system(4.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE6H Gene
Germ Layers:
- ectoderm
Systems:
- nervous
Organs:
Head and neck:
- brain
- cranial nerve
- eye
- eyelid
- head
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for PDE6H
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PDE6H Gene
Orthologs for PDE6H Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PDE6H 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PDE6H 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PDE6H 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PDE6H 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pde6h 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pde6h 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | PDE6H 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PDE6H 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pde6h 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:112320 34 |
|
ManyToMany | |
| zgc:73359 33 |
|
- Species where no ortholog for PDE6H was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PDE6H Gene
(1) SIMAP similar genes for PDE6H Gene using alignment to 1 proteins:
Variants for PDE6H Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11056264 | benign, Cone dystrophy 3 | 14,973,069(+) | G/C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs114575851 | likely-benign, Cone dystrophy 3 | 14,977,984(+) | G/C | 5_prime_UTR_variant | |
| rs144778897 | uncertain-significance, Cone dystrophy 3 | 14,981,547(+) | C/T | 3_prime_UTR_variant | |
| rs200311463 | pathogenic, Achromatopsia 6, Retinal cone dystrophy 3A | 14,978,047(+) | C/G | coding_sequence_variant, stop_gained | |
| rs2230872 | benign, Cone dystrophy 3 | 14,981,419(+) | A/G | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1394n100 | CNV | gain | 25217958 |
| esv3628659 | CNV | gain | 21293372 |
| nsv951333 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.42;
9.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PDE6H Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE6H Gene
Disorders for PDE6H Gene
(4) MalaCards diseases for PDE6H Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinal cone dystrophy 3a |
|
|
| achromatopsia |
|
|
| cone dystrophy |
|
|
| color blindness |
|
|
Search PDE6H in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CNCG_HUMAN- Cone dystrophy, retinal 3A (RCD3A) [MIM:610024]: A rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. {ECO:0000269 PubMed:15629837}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PDE6H
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PDE6H Gene
Publications for PDE6H Gene
- Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H). (PMID: 8786098) Shimizu-Matsumoto A … Okubo K (Genomics 1996) 2 3 4 22 58
- A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy. (PMID: 15629837) Piri N … Farber DB (Ophthalmology 2005) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for PDE6H Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 18 available PDE6H Antibodies ranked by validation data
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- antibodies-online: Search results for available PDE6H related products ranked by validation data
- antibodies-online: Search results for 4 available PDE6H Proteins ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for PDE6H gene
- ViGene Biosciences lentiviral particle packaged cDNA for PDE6H gene
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Sources for PDE6H Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew