Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PDE6G Gene

protein-coding   GIFtS: 66
GCID: GC17M079617

Phosphodiesterase 6G, CGMP-Specific, Rod, Gamma


(Previous symbol: PDEG)
  See PDE6G-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phosphodiesterase 6G, CGMP-Specific, Rod, Gamma1 2     Retinal Rod Rhodopsin-Sensitive CGMP 3',5'-Cyclic Phosphodiesterase
Subunit Gamma2
PDEG1 2 3 5     Rod CG-PDE G2
GMP-PDE Gamma2 3     EC 3.1.4.353
RP572 5     EC 3.1.4.178

External Ids:    HGNC: 87891   Entrez Gene: 51482   Ensembl: ENSG000001855277   OMIM: 1800735   UniProtKB: P185453   
ORGUL members:         

Export aliases for PDE6G gene to outside databases

Previous GC identifers: GC17U990070 GC17M080177 GC17M080313 GC17M077227 GC17M075063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PDE6G Gene:
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta-
catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and
functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has
been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Feb 2009)

GeneCards Summary for PDE6G Gene:
PDE6G (phosphodiesterase 6G, cGMP-specific, rod, gamma) is a protein-coding gene. Diseases associated with PDE6G include pde6g-related retinitis pigmentosa, and retinitis pigmentosa 57. GO annotations related to this gene include enzyme inhibitor activity and 3',5'-cyclic-GMP phosphodiesterase activity. An important paralog of this gene is PDE6H.

UniProtKB/Swiss-Prot: CNRG_HUMAN, P18545
Function: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the
effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

summary for PDE6G Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE6G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE6G gene promoter:
         HFH-3   HTF   SREBP-1c   SREBP-1b   C/EBPalpha   FOXI1   SREBP-1a   ATF6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE6G promoter sequence
   Search Chromatin IP Primers for PDE6G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE6G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q21.1

PDE6G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE6G gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079617:  view genomic region     (about GC identifiers)

Start:
79,617,489 bp from pter      End:
79,630,142 bp from pter
Size:
12,654 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CNRG_HUMAN, P18545 (See protein sequence)
Recommended Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma  
Size: 87 amino acids; 9643 Da
Subunit: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta
chain
Sequence caution: Sequence=CAD97656.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=EAW89666.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for PDE6G:
3JWR (3D)    
Secondary accessions: Q3KP63 Q7Z3U8

Explore the universe of human proteins at neXtProt for PDE6G: NX_P18545

Explore proteomics data for PDE6G at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PDE6G (P18545)
     HLELHELAQ  GFGDDIPGMEGLGTDITVICPWEAF  TPRKGPPKFKQRQTRQFKSKPPKKGV 


    See PDE6G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002593.1  
    ENSEMBL proteins: 
     ENSP00000460962   ENSP00000458567   ENSP00000458167   ENSP00000461464   ENSP00000328412  
    Reactome Protein details: P18545

    PDE6G Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PDE6G
    OriGene Protein Over-expression Lysate for PDE6G
    OriGene MassSpec for PDE6G
    OriGene Custom Protein Services for PDE6G
    GenScript Custom Purified and Recombinant Proteins Services for PDE6G
    Novus Biologicals PDE6G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE6G

     
    Search eBioscience for Proteins for PDE6G 

     
    antibodies-online proteins for PDE6G (2 products) 

     
    antibodies-online peptides for PDE6G

    PDE6G Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PDE6G
    OriGene Custom Antibody Services for PDE6G
    Novus Biologicals PDE6G Antibodies
    Abcam antibodies for PDE6G
    Cloud-Clone Corp. Antibodies for PDE6G
    ThermoFisher Antibodies for PDE6G
    antibodies-online antibodies for PDE6G (17 products) 

    PDE6G Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDE6G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDE6G
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDE6G
    Cloud-Clone Corp. CLIAs for PDE6G
    Search eBioscience for ELISAs for PDE6G 
    antibodies-online kits for PDE6G (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE6G
    Phosphodiesterases, 3',5'-cyclic nucleotide

    1 InterPro protein domain:
     IPR006952 PDE6_gamma

    Graphical View of Domain Structure for InterPro Entry P18545

    ProtoNet protein and cluster: P18545

    1 Blocks protein domain: IPB006952 Retinal cGMP phosphodiesterase

    UniProtKB/Swiss-Prot: CNRG_HUMAN, P18545
    Similarity: Belongs to the rod/cone cGMP-PDE gamma subunit family


    Find genes that share domains with PDE6G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNRG_HUMAN, P18545
    Function: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the
    effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones
    Catalytic activity: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

         Genatlas biochemistry entry for PDE6G:
    cGMP specific nucleotide phosphodiesterase,class VI,gamma subunit,rod photoreceptor

         Enzyme Numbers (IUBMB): EC 3.1.4.172 EC 3.1.4.351

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:0004857enzyme inhibitor activity TAS7828894
    GO:0005515protein binding IPI16357825
    GO:0030553cGMP binding IEA--
    GO:00475553',5'-cyclic-GMP phosphodiesterase activity IEA--
         
    Find genes that share ontologies with PDE6G           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pde6g):
     nervous system  vision/eye 

    Find genes that share phenotypes with PDE6G           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pde6gtm1Goff for PDE6G

       genOway: Develop your customized and physiologically relevant rodent model for PDE6G

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDE6G:
    hsa-mir-335-5p (MIRT018578)

    Block miRNA regulation of human, mouse, rat PDE6G using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PDE6G
    SwitchGear 3'UTR luciferase reporter plasmidPDE6G 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDE6G
    Predesigned siRNA for gene silencing in human, mouse, rat PDE6G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDE6G

    Clone
    Products:
         
    OriGene clones in human, mouse for PDE6G (see all 6)
    OriGene ORF clones in mouse, rat for PDE6G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDE6G (NM_002602)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE6G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE6G

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDE6G
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDE6G 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE6G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0097381photoreceptor disc membrane TAS--

    Find genes that share ontologies with PDE6G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PDE6G About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    Visual signal transduction- Rods0.51
    Activation of the phototransduction cascade0.00
    Phototransduction0.51
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    4Signaling by GPCR
    Signal Transduction0.58
    5Purine metabolism (KEGG)
    Purine metabolism0.38


    Find genes that share SuperPaths with PDE6G           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PDE6G
        Visual Cycle in Retinal Rods

    1 BioSystems Pathway for PDE6G
        Visual signal transduction- Rods

    3 Reactome Pathways for PDE6G
        Activation of the phototransduction cascade
    Ca2+ pathway
    Inactivation, recovery and regulation of the phototransduction cascade


    2 Kegg Pathways  (Kegg details for PDE6G):
        Purine metabolism
    Phototransduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDE6G
    Interactions:

        Search GeneGlobe Interaction Network for PDE6G

    Selected Interacting proteins for PDE6G (P185451, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK1P250983I2D: score=2 
    DNM2P505703I2D: score=2 
    GRB2P629933I2D: score=2 
    SRCP129313I2D: score=2 
    FNBP1Q96RU33I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0007596blood coagulation ----
    GO:0007601visual perception IEA--
    GO:0007603phototransduction, visible light TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    Find genes that share ontologies with PDE6G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PDE6G available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    5 HMDB Compounds for PDE6G    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for PDE6G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-ISOBUTYL-1-METHYLXANTHINE-- --target--10592235
    Sildenafil-- 139755-83-2targetinhibitor16815627
    Vardenafil-- 224785-90-4targetallosteric modulator18779324



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PDE6G gene: 
    NM_002602.3  

    Unigene Cluster for PDE6G:

    Phosphodiesterase 6G, cGMP-specific, rod, gamma
    Hs.654482  [show with all ESTs]
    Unigene Representative Sequence: BX537414
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574024 ENST00000573076 ENST00000574777 ENST00000571224 ENST00000571004
    ENST00000331056(uc002kay.3 uc002kaz.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDE6G using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PDE6G
    SwitchGear 3'UTR luciferase reporter plasmidPDE6G 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDE6G
    Predesigned siRNA for gene silencing in human, mouse, rat PDE6G
    Clone
    Products:
         
    OriGene clones in human, mouse for PDE6G (see all 6)
    OriGene ORF clones in mouse, rat for PDE6G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDE6G (NM_002602)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE6G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE6G
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PDE6G
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDE6G
      QuantiTect SYBR Green Assays in human, mouse, rat PDE6G
      QuantiFast Probe-based Assays in human, mouse, rat PDE6G

    Additional mRNA sequence: 

    BC106884.2 BX537414.1 BX647779.1 M36476.1 NR_026872.1 

    6 DOTS entries:

    DT.218707  DT.100764699  DT.100030311  DT.92422595  DT.97793154  DT.100641138 

    Selected AceView cDNA sequences (see all 207):

    BQ640465 R93834 AI656577 AA317396 BQ637381 BQ638026 BQ639091 BU733107 
    H92486 BM690211 BM662146 H92229 BM704333 BM662372 BM708172 BQ638010 
    BG218705 BQ640109 BQ637839 H86521 BQ636335 BQ640639 BG219705 H93437 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PDE6G    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for PDE6G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PDE6G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGTAGCA
    PDE6G Expression
    About this image


    PDE6G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
    PDE6G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE6G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654482
        Custom PCR Arrays for PDE6G
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PDE6G
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDE6G
    QuantiTect SYBR Green Assays in human, mouse, rat PDE6G
    QuantiFast Probe-based Assays in human, mouse, rat PDE6G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE6G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PDE6G gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde6g1 , 5 phosphodiesterase 6G, cGMP-specific, rod, gamma1, 5 89.66(n)1
    96.55(a)1
      11 (84.14 cM)5
    185881  NM_012065.21  NP_036197.11 
     1204476055 
    chicken
    (Gallus gallus)
    Aves PDE6G1 phosphodiesterase 6G, cGMP-specific, rod, gamma 82.76(n)
    90.8(a)
      395091  NM_204445.2  NP_989776.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDE6G6
    phosphodiesterase 6G, cGMP-specific, rod, gamma
    89(a)
    1 ↔ 1
    2(98502576-98506258)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480632132   -- 84.81(n)    48063213 
    zebrafish
    (Danio rerio)
    Actinopterygii pde6g2 phosphodiesterase 6G, cGMP-specific, rod, gamma 80.66(n)   373876  BC045848.1 


    ENSEMBL Gene Tree for PDE6G (if available)
    TreeFam Gene Tree for PDE6G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PDE6G gene
    PDE6H2  
    1 SIMAP similar gene for PDE6G using alignment to 2 protein entries:     CNRG_HUMAN (see all proteins):
    PDE6H

    Find genes that share paralogs with PDE6G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PDE6G (see all 226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602438811,2
    C--79620348(+) TGACG-/GAGACA 2 -- ut51 int10--------
    rs114310431,2
    C--79621409(+) TTTTT-/TTTTTT 2 -- int1 trp30--------
    rs606766281,2
    C--79621783(+) TTTTTT/-AGACG 2 -- int11Minor allele frequency- -:0.50NA 2
    rs38427091,2
    C--79622721(-) CCTGTCTGT/-  
            
    GTCAT
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs711661641,2
    C--79624010(+) CCCCC-/CC/CCC
            
    GCCCT
    3 -- us2k1 cds12NA 4
    rs118700661,2
    C,F,H--79624912(+) tttcaG/Aatgaa 2 -- us2k1 tfbs32Minor allele frequency- A:0.50NA 4
    rs1440872591,2
    C--80729988(+) CTCCCA/GCCTTG 2 -- ds5001 int10--------
    rs1839131311,2
    --80730072(+) AAGGAC/TGAGCT 2 -- ds5001 int10--------
    rs743678771,2
    C--80730152(+) AGCTCC/TGGCCT 2 -- ds5001 int10--------
    rs1884601421,2
    --80730156(+) CCGGCC/TTCACG 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for PDE6G (79617489 - 79630142 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDE6G (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716457CNV Deletion23290073
    dgv3330n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv828128CNV Loss20364138
    nsv909109CNV Loss21882294
    nsv909052CNV Loss21882294
    dgv3332n71CNV Loss21882294
    nsv470620CNV Loss18288195
    nsv909111CNV Loss21882294
    nsv428351CNV Gain18775914

    Human Gene Mutation Database (HGMD): PDE6G
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDE6G
    DNA2.0 Custom Variant and Variant Library Synthesis for PDE6G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 180073   
    OMIM disorders: 613582  
    UniProtKB/Swiss-Prot: CNRG_HUMAN, P18545
  • Retinitis pigmentosa 57 (RP57) [MIM:613582]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 5 diseases for PDE6G:    
    About MalaCards
    pde6g-related retinitis pigmentosa    retinitis pigmentosa 57    familial retinoblastoma    idiopathic pulmonary fibrosis
    leber congenital amaurosis

    2 diseases from the University of Copenhagen DISEASES database for PDE6G:
    Retinitis pigmentosa     Familial retinoblastoma

    Find genes that share disorders with PDE6G           About GenesLikeMe

    2 Novoseek inferred disease relationships for PDE6G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 79.3 1 9385361 (1)
    retinal degeneration 72.5 2 8125719 (2)


    Export disorders for PDE6G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PDE6G gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with PDE6G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa. (PubMed id 8125719)1, 2, 9 Hahn L.B.... Dryja T.P. (Invest. Ophthalmol. Vis. Sci. 1994)
    2. Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina. (PubMed id 2161380)1, 2, 9 Tuteja N.... Farber D.B. (Gene 1990)
    3. Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase. (PubMed id 20655036)1, 2 Dvir L.... Ben-Yosef T. (Am. J. Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase. (PubMed id 1965799)1, 2 Piriyev N.I.... Lipkin V.M. (Dokl. Akad. Nauk SSSR 1990)
    6. Determinants for phosphodiesterase 6 inhibition by its gamma-subunit. (PubMed id 20397626)1 Zhang Z. and Artemyev N.O. (Biochemistry 2010)
    7. Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. (PubMed id 20979602)1 Nikolova S....Pullamsetti S.S. (Respir. Res. 2010)
    8. Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit. (PubMed id 19798052)1 Barren B....Artemyev N.O. (EMBO J. 2009)
    9. Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. (PubMed id 18779324)7 Zhang X.J....Cote R.H. (J. Biol. Chem. 2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5148 HGNC: 8789 AceView: PDE6G Ensembl:ENSG00000185527 euGenes: HUgn5148
    ECgene: PDE6G Kegg: 5148 H-InvDB: PDE6G

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PDE6G Pharmacogenomics, SNPs, Pathways
    Mutations of the PDE6A/B/G geneshttp://www.retina-international.org/files/sci-news/pdemut.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PDE6G gene:
    Search GeneIP for patents involving PDE6G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PDE6G   OriGene RNAi products in human, mouse, rat for PDE6G  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PDE6G  
     OriGene MassSpec for PDE6G   OriGene clones in human, mouse for PDE6G  
     OriGene qSTAR qPCR primer pairs in human, mouse for PDE6G   OriGene Purified Protein for PDE6G  
     OriGene ORF clones in mouse, rat for PDE6G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDE6G   OriGene Custom Protein Services for PDE6G  

     
     
     Block miRNA regulation of human, mouse, rat PDE6G using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PDE6G
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE6G Predesigned siRNA for gene silencing in human, mouse, rat PDE6G
     QuantiFast Probe-based Assays in human, mouse, rat PDE6G QuantiTect SYBR Green Assays in human, mouse, rat PDE6G
     Custom PCR Arrays for PDE6G Search Chromatin IP Primers for PDE6G
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDE6G  Search GeneGlobe Interaction Network for PDE6G
     Regulatory tfbs in PDE6G promoter
     GenScript Custom Purified and Recombinant Proteins Services for PDE6G GenScript cDNA clones with any tag delivered in your preferred vector for PDE6G
     GenScript Custom Assay Services for PDE6G GenScript Custom overexpressing Cell Line Services for PDE6G
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PDE6G
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PDE6G antibodies
     PDE6G lysates
     Antibodies for PDE6G
     See all of Abcam's Antibodies, Kits and Proteins for PDE6G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PDE6G
     Antibodies for PDE6G
     ELISAs for PDE6G
     CLIAs for PDE6G



     Browse ESI BIO Cell Lines and PureStem Progenitors for PDE6G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE6G
     SwitchGear 3'UTR luciferase reporter plasmids for PDE6G
     SwitchGear Promoter luciferase reporter plasmids for PDE6G
     ThermoFisher Antibodies for PDE6G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE6G
     Browse compounds at ApexBio
     Search Addgene for plasmids for PDE6G
      Search eBioscience for proteins for PDE6G
      Search eBioscience for elisas for PDE6G
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PDE6G
     antibodies-online antibodies for PDE6G (17 products)
     antibodies-online kits for PDE6G (4 products)
     antibodies-online peptides for PDE6G
     antibodies-online proteins for PDE6G (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PDE6G gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4