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PDE5A Gene

protein-coding   GIFtS: 68
GCID: GC04M120415

Phosphodiesterase 5A, CGMP-Specific

  See PDE5A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphodiesterase 5A, CGMP-Specific1 2     CGMP-Specific 3',5'-Cyclic Phosphodiesterase2
CGB-PDE2 3     CGMP-Specific Phosphodiesterase PDE5A22
PDE52 3     CGMP-Specific Phosphodiesterase Type 5A2
EC 3.1.4.353 8     Phosphodiesterase Isozyme 52
CN5A2     CGMP-Binding CGMP-Specific Phosphodiesterase3
CGMP-Binding CGMP-Specific 3',5'-Cyclic Nucleotide Phosphodiesterase2     EC 3.1.48

External Ids:    HGNC: 87841   Entrez Gene: 86542   Ensembl: ENSG000001387357   OMIM: 6033105   UniProtKB: O760743   

Export aliases for PDE5A gene to outside databases

Previous GC identifers: GC04M121176 GC04M120698 GC04M120811 GC04M120877 GC04M120878 GC04M120776 GC04M116136


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDE5A Gene:
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide
phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the
regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in
the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding
distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDE5A Gene:
PDE5A (phosphodiesterase 5A, cGMP-specific) is a protein-coding gene. Diseases associated with PDE5A include transient global amnesia, and peyronies disease. GO annotations related to this gene include cGMP binding and 3',5'-cyclic-GMP phosphodiesterase activity. An important paralog of this gene is PDE11A.

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides.
This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP

summary for PDE5A Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE5A (CGMP-specific phosphodiesterase type 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE5A gene promoter:
         C/EBPbeta   Nkx6-1   Cdc5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE5A promoter sequence
   Search Chromatin IP Primers for PDE5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q27

PDE5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE5A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M120415:  view genomic region     (about GC identifiers)

Start:
120,415,550 bp from pter      End:
120,550,146 bp from pter
Size:
134,597 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074 (See protein sequence)
Recommended Name: cGMP-specific 3',5'-cyclic phosphodiesterase  
Size: 875 amino acids; 99985 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions
Selected PDB 3D structures from and Proteopedia for PDE5A (see all 33):
1RKP (3D)        1T9R (3D)        1T9S (3D)        1TBF (3D)        1UDT (3D)        1UDU (3D)    
Secondary accessions: A0AV69 A8K2C4 O75026 O75887 Q86UI0 Q86V66 Q9Y6Z6
Alternative splicing: 2 isoforms:  O76074-1   O76074-2   

Explore the universe of human proteins at neXtProt for PDE5A: NX_O76074

Explore proteomics data for PDE5A at MOPED

Post-translational modifications: 

  • Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by
    PRKG1 leads to its activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE5A (O76074) (see all 15)
     HDLDHRG  EFFDQGD  GIVGHVA  IFCGLGI 


    See PDE5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001074.2  NP_236914.2  NP_246273.2  

    ENSEMBL proteins: 
     ENSP00000347046   ENSP00000264805   ENSP00000425810   ENSP00000416309   ENSP00000377957  
    Reactome Protein details: O76074

    PDE5A Human Recombinant Protein Products:

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    Novus Biologicals PDE5A Protein
    Novus Biologicals PDE5A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE5A

     
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    antibodies-online proteins for PDE5A (3 products) 

     
    antibodies-online peptides for PDE5A

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    antibodies-online antibodies for PDE5A (36 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE5A
    Phosphodiesterases, 3',5'-cyclic nucleotide

    5 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR003018 GAF
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry O76074

    ProtoNet protein and cluster: O76074

    1 Blocks protein domain: IPB003018 GAF domain

    UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074
    Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal
    regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family
    Similarity: Contains 2 GAF domains


    Find genes that share domains with PDE5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE5A_HUMAN, O76074
    Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides.
    This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP
    Catalytic activity: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate
    Enzyme regulation: Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is effective in the
    treatment of penile erectile dysfunction. Also inhibited by zaprinast

         Genatlas biochemistry entry for PDE5A:
    cGMP specific nucleotide phosphodiesterase,class V,alpha subunit,two alternatively spliced forms
    A1,A2,100kDa,highly expressed in tissues,aortic smooth muscle cells,heart,placenta,skeletal
    muscle,pancreas,brain,liver and lung

         Enzyme Numbers (IUBMB): EC 3.1.4.351 2 EC 3.1.42

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004112cyclic-nucleotide phosphodiesterase activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity NAS9714779
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
         
    Find genes that share ontologies with PDE5A           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Pde5a (no phenotypes)

    Find genes that share phenotypes with PDE5A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pde5atm1Lex for PDE5A

       genOway: Develop your customized and physiologically relevant rodent model for PDE5A

    miRNA
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    miRTarBase miRNAs that target PDE5A:
    hsa-mir-335-5p (MIRT017190)

    Block miRNA regulation of human, mouse, rat PDE5A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDE5A (see all 96):
    hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-1245 hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-548a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    cytoskeleton1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PDE5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDE5A About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    2Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    3Hemostasis
    Hemostasis0.43
    4Purine metabolism (KEGG)
    Purine metabolism0.38
    5Platelet homeostasis
    Platelet homeostasis


    Find genes that share SuperPaths with PDE5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PDE5A
        Cellular Effects of Sildenafil

    1 Cell Signaling Technology (CST) Pathway for PDE5A
        Ca, cAMP and Lipid Signaling

    1 GeneGo (Thomson Reuters) Pathway for PDE5A
        NO-dependent CFTR activation (normal and CF)

    1 Reactome Pathway for PDE5A
        cGMP effects


    1 Kegg Pathway  (Kegg details for PDE5A):
        Purine metabolism

    UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074
    Pathway: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Array including PDE5A: 

              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PDE5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE5A (O760743 ENSP000003470464) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425743, ENSP000003110324I2D: score=1 STRING: ENSP00000311032
    PRKG1Q139763, ENSP000003630924I2D: score=1 STRING: ENSP00000363092
    ADCY10ENSP000003568254STRING: ENSP00000356825
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY3ENSP000002606004STRING: ENSP00000260600
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0009187cyclic nucleotide metabolic process ----
    GO:0010613positive regulation of cardiac muscle hypertrophy IEA--
    GO:0042130negative regulation of T cell proliferation IEA--

    Find genes that share ontologies with PDE5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PDE5A
      Browse compounds at ApexBio 

    Compounds for PDE5A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    10 HMDB Compounds for PDE5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    CobaltCo (see all 6)7440-48-4--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    SildenafilCaverta (see all 4)139755-83-2--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected DrugBank Compounds for PDE5A (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sildenafil-- 139755-83-2targetinhibitor12567500 16735511 17959709 17979301 11752352 12414329 12477710 12614192 12554648
    Vardenafil-- 224785-90-4targetinhibitor14626653 11890515 11669467 12625845 16926278 17959709 17979301 11752352 12955149
    TadalafilICOS 351 (see all 2)171596-29-5targetinhibitor12074215 12603396 12891884 17979301 14498756 11752352 12625031
    DipyridamoleDipiridamol (see all 6)58-32-2targetinhibitor15672122 17308037 11752352 16080974 16886928
    Udenafil-- 268203-93-6targetinhibitor18491987 21054754 19465935 11752352 19860692
    Citric Acid-- 77-92-9target--17139284 17016423
    Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine-- --target--17139284 17016423
    Guanosine-5'-Monophosphate-- 85-32-5target--17139284 17016423
    3-ISOBUTYL-1-METHYLXANTHINE-- --target--10592235
    5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide-- --target--10592235

    4 IUPHAR Ligands for PDE5A (PDE5A)    About this table
    LigandTypeActionAffinityPubmed IDs
    T0156
    InhibitorInhibition9.512450574
    sildenafil
    InhibitorInhibition910385692
    SCH51866
    InhibitorInhibition7.28961086
    zaprinast
    InhibitorInhibition6.810385692

    Selected Novoseek inferred chemical compound relationships for PDE5A gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vardenafil 97.8 218 15312980 (6), 14636086 (4), 17138653 (3), 15464333 (3) (see all 99)
    tadalafil 97.5 212 16409221 (5), 15941818 (3), 15464333 (3), 19768639 (3) (see all 99)
    sildenafil 96.9 495 20086037 (8), 10385692 (6), 15312980 (6), 10078537 (5) (see all 99)
    cgmp 90.5 657 19665054 (10), 12554648 (6), 9445376 (5), 12761347 (5) (see all 99)
    zaprinast 82.5 30 10385692 (3), 7653611 (2), 9497379 (1), 9598563 (1) (see all 24)
    piclamilast 75.8 2 11834608 (1), 15339393 (1)
    nitric oxide 70.1 182 17275845 (5), 15295092 (5), 12604588 (5), 15640438 (3) (see all 80)
    exisulind 68.3 7 10910034 (2), 17305584 (1), 11358813 (1), 15526282 (1) (see all 5)
    guanylate 64.1 9 12437503 (2), 20132096 (1), 19907424 (1), 19705340 (1) (see all 8)
    motapizone 63.1 1 11834608 (1)



    Find genes that share compounds with PDE5A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE5A gene (3 alternative transcripts): 
    NM_001083.3  NM_033430.2  NM_033437.3  

    Unigene Cluster for PDE5A:

    Phosphodiesterase 5A, cGMP-specific
    Hs.647971  [show with all ESTs]
    Unigene Representative Sequence: NM_001083
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354960(uc003idf.3 uc003idh.3) ENST00000264805 ENST00000503412
    ENST00000512494 ENST00000509612 ENST00000513594 ENST00000512450 ENST00000512739
    ENST00000502912 ENST00000508914 ENST00000420633 ENST00000394439(uc003idg.3)

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    Selected qRT-PCR Assays for microRNAs that regulate PDE5A (see all 96):
    hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-1245 hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-548a-5p
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    Additional mRNA sequence: 

    AB015656.1 AF043731.1 AF043732.1 AF155192.1 AF155193.1 AF155194.1 AJ004865.1 AK091302.1 
    AK290189.1 AY264918.1 AY266363.1 BC126233.1 JQ286346.1 

    10 DOTS entries:

    DT.100754842  DT.97786450  DT.315121  DT.97791706  DT.40224319  DT.205491  DT.404201  DT.95176543 
    DT.97813364  DT.99957235 

    Selected AceView cDNA sequences (see all 142):

    BU146143 BF221547 AI821756 AA461399 CA393872 AA382741 AA653566 AY264918 
    CA437264 NM_033430 AF155192 AI792083 AB015656 AW130701 BU683142 BU616900 
    AL703578 AL701932 BM711448 CA443169 AI792099 H90636 BX099915 CA443303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDE5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PDE5A Expression
    About this image


    PDE5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Membranous Facial Bones
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
    PDE5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647971

    UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074
    Tissue specificity: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to
    a much lesser extent, in brain, liver and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including PDE5A: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PDE5A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde5a1 , 5 phosphodiesterase 5A, cGMP-specific1, 5 88.79(n)1
    93.53(a)1
      3 (53.69 cM)5
    2422021  NM_153422.21  NP_700471.21 
     1227291585 
    chicken
    (Gallus gallus)
    Aves PDE5A1 phosphodiesterase 5A, cGMP-specific 81.99(n)
    88.86(a)
      422677  XM_420631.4  XP_420631.3 
    lizard
    (Anolis carolinensis)
    Reptilia PDE5A6
    phosphodiesterase 5A, cGMP-specific
    84(a)
    1 ↔ 1
    5(139896491-139966793)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pde5a1 phosphodiesterase 5a, cGMP-specific 75.77(n)
    81.06(a)
      780273  NM_001079344.1  NP_001072812.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pde5ab1 phosphodiesterase 5A, cGMP-specific, b 70.14(n)
    74.4(a)
      553270  NM_001123260.1  NP_001116732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102313
    Pde111
    cGMP-specific phosphodiesterase3
    Phosphodiesterase 111
    48(a)
    (best of 2)3
    54.04(n)1
    51.06(a)1
      351071  NM_001201908.11  NP_001188837.11 


    ENSEMBL Gene Tree for PDE5A (if available)
    TreeFam Gene Tree for PDE5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE5A gene
    PDE11A2  PDE6A2  PDE3A2  PDE6B2  PDE6C2  PDE2A2  PDE10A2  PDE3B2  
    9 SIMAP similar genes for PDE5A using alignment to 9 protein entries:     PDE5A_HUMAN (see all proteins):
    PDE11A    PDE6B    PDE6A    PDE2A    PDE4    PDE10A
    PDE6C    PDE7B variant protein    PDE9A

    Find genes that share paralogs with PDE5A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE5A (see all 2612)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359520891,2
    C--116271277(+) AGGAG-/G/GGC 
            
    GCGGC
    6 -- us2k1 cds11NA 2
    rs1812910531,2
    --120421272(+) AAGCAA/GCTGTT 3 -- int10--------
    rs1481507701,2
    --120421312(+) AAACAA/GTGCTC 3 -- int10--------
    rs798091021,2
    C,F--120421380(+) TGCTGA/GGAAAA 3 -- int11Minor allele frequency- G:0.11WA 118
    rs783642101,2
    C,F--120421396(+) GAGACG/AACAGT 3 -- int11Minor allele frequency- A:0.09WA 118
    rs345807251,2
    C--120421418(+) CCTAG-/TTTTTT 3 -- int12Minor allele frequency- T:0.25NA 4
    rs102134981,2
    C,F--120421607(+) tgaacT/Gttaca 3 -- int15Minor allele frequency- G:0.04NA WA 126
    rs2011846271,2
    C--120421658(+) CTAGG-/TTTTTT 3 -- int10--------
    rs2017199381,2
    --120421766(+) GACAA-/CTTCTTCT 3 -- int10--------
    rs93074771,2
    C,F--120421809(+) AATAAA/GTTAGA 3 -- int110Minor allele frequency- G:0.46NA WA CSA EA 371

    HapMap Linkage Disequilibrium report for PDE5A (120415550 - 120550146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PDE5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728237CNV Deletion23290073
    dgv5700n71CNV Loss21882294
    nsv822710CNV Loss20364138
    dgv5698n71CNV Loss21882294
    nsv879848CNV Loss21882294
    dgv5699n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603310    OMIM disorders: --

    8 diseases for PDE5A:    
    About MalaCards
    transient global amnesia    peyronies disease    impotence    arteritic anterior ischemic optic neuropathy
    premature ejaculation    non-arteritic anterior ischemic optic neuropathy    priapism    anterior ischemic optic neuropathy

    10 diseases from the University of Copenhagen DISEASES database for PDE5A:
    Premature ejaculation     Sexual dysfunction     Hypertension     Priapism
    Ischemic optic neuropathy     Dyspepsia     Hypogonadism     Peyronie's disease
    Diabetes mellitus     Heart disease

    Find genes that share disorders with PDE5A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PDE5A gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erectile dysfunction 95.8 275 17253475 (5), 17948826 (3), 17076943 (3), 18674473 (3) (see all 99)
    hypertension pulmonary 71.8 42 17305584 (2), 19416631 (2), 15907910 (2), 15817798 (2) (see all 33)
    benign prostatic hyperplasia 66.3 14 16387566 (1), 16956354 (1), 19796053 (1), 17329019 (1) (see all 11)
    naion 64.7 32 17076943 (4), 18528398 (4), 17947271 (3), 17969789 (1) (see all 9)
    hypertension arterial 63.6 29 17606845 (2), 15907910 (2), 18689467 (2), 15466636 (1) (see all 23)
    priapism 63.5 25 17100941 (5), 12853767 (3), 16698365 (3), 19267844 (2) (see all 8)
    hypogonadism 62.7 8 16939550 (2), 17309554 (2), 16422803 (1), 18641415 (1)
    congestion 50.4 5 12161769 (1), 15224134 (1), 15115191 (1), 11249556 (1) (see all 5)
    peyronie disease 50 2 17942972 (1), 16885993 (1)
    impotence 49.6 4 10541153 (1), 18778098 (1), 12789393 (1), 17017938 (1) (see all 5)

    Genetic Association Database (GAD): PDE5A
    Human Genome Epidemiology (HuGE) Navigator: PDE5A (6 documents)

    Export disorders for PDE5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE5A gene, integrated from 10 sources (see all 617):
    (articles sorted by number of sources associating them with PDE5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (PubMed id 9714779)1, 2, 3, 9 Loughney K.... Ferguson K. (Gene 1998)
    2. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (PubMed id 12955149)1, 2, 7 Sung B.-J.... Cho J.M. (Nature 2003)
    3. Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase. (PubMed id 9642111)1, 2, 3 Stacey P.... Phillips S.C. (Biochem. Biophys. Res. Commun. 1998)
    4. PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. (PubMed id 12554648)1, 7, 9 Rybalkin S.D....Beavo J.A. (EMBO J. 2003)
    5. Expression, structure and chromosomal localization of the human cGMP- binding cGMP-specific phosphodiesterase PDE5A gene. (PubMed id 9716380)1, 2, 9 Yanaka N.... Omori K. (Eur. J. Biochem. 1998)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Phosphodiesterase-5 gene (PDE5A) polymorphisms are associated with progression of childhood IgA nephropathy. (PubMed id 20563733)1, 4 Hahn W.H....Cho B.S. (Pediatr. Nephrol. 2010)
    8. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    9. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8654 HGNC: 8784 AceView: PDE5A Ensembl:ENSG00000138735 euGenes: HUgn8654
    ECgene: PDE5A Kegg: 8654 H-InvDB: PDE5A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDE5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE5A gene:
    Search GeneIP for patents involving PDE5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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