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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDE5A Gene

protein-coding GIFtS: 64
GCID: GC04M120415

phosphodiesterase 5A, cGMP-specific

Explore 61 diseases affiliated with
PDE5A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphodiesterase 5A, CGMP-Specific¹ ²		CGMP-Specific 3',5'-Cyclic Phosphodiesterase²
CGB-PDE² ³		CGMP-Specific Phosphodiesterase PDE5A2²
PDE5² ³		CGMP-Specific Phosphodiesterase Type 5A²
EC 3.1.4.35³ ⁸		Phosphodiesterase Isozyme 5²
CN5A²		CGMP-Binding CGMP-Specific Phosphodiesterase³
CGMP-Binding CGMP-Specific 3',5'-Cyclic Nucleotide Phosphodiesterase²		EC 3.1.4⁸

External Ids:	HGNC: 8784¹	Entrez Gene: 8654²	Ensembl: ENSG00000138735⁷	OMIM: 603310⁵	UniProtKB: O76074³

Export aliases for PDE5A gene to outside databases

Previous GC identifers: GC04M121176 GC04M120698 GC04M120811 GC04M120877 GC04M120878 GC04M120776 GC04M116136

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE5A:

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase

family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of

intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular

system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This

phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP

summary for PDE5A:

Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the

hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or

cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by

controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8

selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both

cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue

distribution. These enzymes are involved in many signal transduction pathways and their functions include

vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone

secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE5A (CGMP-specific phosphodiesterase type 5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDE5A gene promoter:
C/EBPbeta Nkx6-1 Cdc5 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDE5A promoter sequence

Search SABiosciences Chromatin IP Primers for PDE5A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE5A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q27

PDE5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE5A gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M120415: view genomic region (about GC identifiers)

Start:	120,415,550 bp from pter	End:	120,550,146 bp from pter
Size:	134,597 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074 (See protein sequence)

Recommended Name: cGMP-specific 3',5'-cyclic phosphodiesterase

Size: 875 amino acids; 99985 Da

Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a

preference for magnesium and/or manganese ions

6/29 PDB 3D structures from and Proteopedia for PDE5A (see all 29):

1RKP (3D)

1T9R (3D)

1T9S (3D)

1TBF (3D)

1UDT (3D)

1UDU (3D)

Secondary accessions: A0AV69 A8K2C4 O75026 O75887 Q86UI0 Q86V66 Q9Y6Z6

Alternative splicing: 2 isoforms: O76074-1 O76074-2

Explore the universe of human proteins at neXtProt for PDE5A: NX_O76074

Post-translational modifications:

Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1

leads to its activation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O76074

4/15 DME Specific Peptides for PDE5A (O76074) (see all 15)

HDLDHRG

EFFDQGD

GIVGHVA

IFCGLGI

PDE5A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001074.2 NP_236914.2 NP_246273.2

ENSEMBL proteins:

ENSP00000347046 ENSP00000264805 ENSP00000425810 ENSP00000416309 ENSP00000377957

Reactome Protein details: O76074
Human Recombinant Protein Products for PDE5A:

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	Novus Biologicals PDE5A Protein Novus Biologicals PDE5A Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PDE5A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005829	cytosol	TAS	--

PDE5A for ontologies About GeneDecksing

PDE5A Antibody Products:

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	Abcam antibodies for PDE5A
	Uscn Antibodies for PDE5A
	ThermoFisher Antibodies for PDE5A

Assay Products for PDE5A:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PDE5A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PDE5A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDE5A for domains About GeneDecksing

5 InterPro domains/families:

IPR002073 PDEase_catalytic_dom

IPR003018 GAF

IPR023174 PDEase_CS

IPR023088 PDEase

IPR003607 HD/PDEase_dom

Graphical View of Domain Structure for InterPro Entry O76074

ProtoNet protein and cluster: O76074

1 Blocks protein family: IPB003018 GAF domain

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal

regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family

Similarity: Contains 2 GAF domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PDE5A_HUMAN, O76074

Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This

phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP

Catalytic activity: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

Enzyme regulation: Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is effective in the

treatment of penile erectile dysfunction. Also inhibited by zaprinast

Genatlas biochemistry entry for PDE5A:

cGMP specific nucleotide phosphodiesterase,class V,alpha subunit,two alternatively spliced forms A1,A2,100kDa,highly

expressed in tissues,aortic smooth muscle cells,heart,placenta,skeletal muscle,pancreas,brain,liver and lung

Enzyme Numbers (IUBMB): EC 3.1.4.35¹ ² EC 3.1.4²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004112	cyclic-nucleotide phosphodiesterase activity	--	--
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	NAS	9714779
GO:0008270	zinc ion binding	NAS	--
GO:0030553	cGMP binding	TAS	15938621
GO:0046872	metal ion binding	--	--

PDE5A for ontologies About GeneDecksing

Phenotypes:
1 MGI phenotypic allele

for Pde5a (no phenotypes)

PDE5A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Pde5a^tm1Lex for PDE5A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PDE5A

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PDE5A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE5A
		8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE5A (see all 96):
		hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-1245 hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-548a-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE5A (see all 7) OriGene shRNA RFP: PDE5A OriGene siRNA: PDE5A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE5A
		Sirion Biotech Custom design and validation of potent shRNA sequences against PDE5A

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PDE5A
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE5A (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE5A (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE5A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PDE5A
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE5A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Nitric oxide stimulates guanylate cyclase

	Nitric oxide stimulates guanylate cyclase	1.00			Platelet homeostasis	0.34
	cGMP effects	0.75

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

NO-dependent CFTR activation (normal and CF)

NO-dependent CFTR activation (normal and CF)

1.00

Purine metabolism

Purine metabolism

1.00

Sweet Taste Signaling

Cellular Effects of Sildenafil

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PDE5A

Cellular Effects of Sildenafil

1 Cell Signaling Technology (CST) Pathway for PDE5A

Ca, cAMP and Lipid Signaling

1 GeneGo (Thomson Reuters) Pathway for PDE5A

NO-dependent CFTR activation (normal and CF)

4 Reactome Pathways for PDE5A

	Hemostasis
	cGMP effects
	Platelet homeostasis
	Nitric oxide stimulates guanylate cyclase

1 Kegg Pathway (Kegg details for PDE5A):

Purine metabolism

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Pathway: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1

PDE5A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PDE5A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for PDE5A (O76074³ ENSP00000347046⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP3	P42574³, ENSP00000311032⁴	I2D: score=1 STRING: ENSP00000311032
PRKG1	Q13976³, ENSP00000363092⁴	I2D: score=1 STRING: ENSP00000363092
ADCY10	ENSP00000356825⁴	STRING: ENSP00000356825
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY3	ENSP00000260600⁴	STRING: ENSP00000260600

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0002026	regulation of the force of heart contraction	--	--
GO:0002678	positive regulation of chronic inflammatory response	--	--
GO:0007165	signal transduction	NAS	--
GO:0007399	nervous system development	--	--

PDE5A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PDE5A for compounds About GeneDecksing

EMD Millipore small molecules for PDE5A:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PDE5A

Compounds for PDE5A available from Tocris Bioscience About this table

Compound	Action	CAS #
Dipyridamole	Adenosine transport inhibitor	[58-32-2]
Zaprinast	PDE5/6/9/11 inhibitor	[37762-06-4]
T 0156 hydrochloride	Highly potent, selective PDE5 inhibitor	[324572-92-1]
MY-5445	PDE5 inhibitor	[78351-75-4]
Gisadenafil besylate	PDE5 inhibitor	[334827-98-4]

10 HMDB Compounds for PDE5A About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Cobalt	Co (see all 6)	7440-48-4	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Manganese	manganese	7439-96-5	--
Sildenafil	Caverta (see all 4)	139755-83-2	--
Theophylline	1,3-Dimethylxanthine (see all 96)	58-55-9	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/12 DrugBank Compounds for PDE5A (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sildenafil	--	139755-83-2	target	inhibitor	12567500 16735511 17959709 17979301 11752352 12414329 12477710 12614192 12554648
Vardenafil	--	224785-90-4	target	inhibitor	14626653 11890515 11669467 12625845 16926278 17959709 17979301 11752352 12955149
Tadalafil	ICOS 351 (see all 2)	171596-29-5	target	inhibitor	12074215 12603396 12891884 17979301 14498756 11752352 12625031
Dipyridamole	Dipiridamol (see all 6)	58-32-2	target	inhibitor	15672122 17308037 11752352 16080974 16886928
Udenafil	--	268203-93-6	target	inhibitor	18491987 21054754 19465935 11752352 19860692
Citric Acid	--	77-92-9	target	--	17139284 17016423
Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine	--	--	target	--	17139284 17016423
Guanosine-5'-Monophosphate	--	85-32-5	target	--	17139284 17016423
3-ISOBUTYL-1-METHYLXANTHINE	--	--	target	--	10592235
5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide	--	--	target	--	10592235

10/58 Novoseek chemical compound relationships for PDE5A gene (see all 58) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vardenafil	97.8	218	15312980 (6), 14636086 (4), 17138653 (3), 15464333 (3) (see all 99)
tadalafil	97.5	212	16409221 (5), 15941818 (3), 15464333 (3), 19768639 (3) (see all 99)
sildenafil	96.9	495	20086037 (8), 10385692 (6), 15312980 (6), 10078537 (5) (see all 99)
cgmp	90.5	657	19665054 (10), 12554648 (6), 9445376 (5), 12761347 (5) (see all 99)
zaprinast	82.5	30	10385692 (3), 7653611 (2), 9497379 (1), 9598563 (1) (see all 24)
piclamilast	75.8	2	11834608 (1), 15339393 (1)
nitric oxide	70.1	182	17275845 (5), 15295092 (5), 12604588 (5), 15640438 (3) (see all 80)
exisulind	68.3	7	10910034 (2), 17305584 (1), 11358813 (1), 15526282 (1) (see all 5)
guanylate	64.1	9	12437503 (2), 20132096 (1), 19907424 (1), 19705340 (1) (see all 8)
motapizone	63.1	1	11834608 (1)

Search CenterWatch for drugs/clinical trials and news about PDE5A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDE5A gene (3 alternative transcripts):

NM_001083.3 NM_033430.2 NM_033437.3

Unigene Cluster for PDE5A:

Phosphodiesterase 5A, cGMP-specific

Hs.647971 [show with all ESTs]

Unigene Representative Sequence: NM_001083

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354960(uc003idf.3 uc003idh.3) ENST00000264805 ENST00000503412

ENST00000512494 ENST00000509612 ENST00000513594 ENST00000512450 ENST00000512739

ENST00000502912 ENST00000508914 ENST00000420633 ENST00000394439(uc003idg.3)

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		hsa-miR-548j hsa-miR-607 hsa-miR-3607-3p hsa-miR-1245 hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-548a-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE5A (see all 7) OriGene shRNA RFP: PDE5A OriGene siRNA: PDE5A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE5A
		Sirion Biotech Custom design and validation of potent shRNA sequences against PDE5A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE5A (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE5A (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PDE5A (NM_033437)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE5A

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PDE5A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE5A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE5A

Additional cDNA sequence:

AB015656.1 AF043731.1 AF043732.1 AF155192.1 AF155193.1 AF155194.1 AJ004865.1 AK091302.1

AK290189.1 AY264918.1 AY266363.1 BC126233.1 JQ286346.1

10 DOTS entries:

DT.100754842 DT.97786450 DT.315121 DT.97791706 DT.40224319 DT.205491 DT.404201 DT.95176543

DT.97813364 DT.99957235

24/142 AceView cDNA sequences (see all 142):

CA443169 BM711448 AY264918 AW130701 BX099915 AI792099 CA437264 BM978332

AA382741 AF155192 H90636 AW152010 CA393872 CA443303 BU146143 AA653566

BU683142 AI814041 BU616900 AA461399 AL701932 NM_033437 AB015656 NM_033430

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDE5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

PDE5A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See PDE5A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE5A

SOURCE GeneReport for Unigene cluster: Hs.647971

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Tissue specificity: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a

much lesser extent, in brain, liver and lung

SABiosciences Expression via Pathway-Focused PCR Array including PDE5A:

Hypertension in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PDE5A gene from 4/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PDE5A¹	phosphodiesterase 5A, cGMP-specific	81.98(n) 88.67(a)		422677 XM_420631.3 XP_420631.3
lizard (Anolis carolinensis)	Reptilia	PDE5A⁶	--	84(a)	1 ↔ 1	5(139896491-139966793)
zebrafish (Danio rerio)	Actinopterygii	pde5ab¹	phosphodiesterase 5A, cGMP-specific, b	70.14(n) 74.4(a)		553270 NM_001123260.1 NP_001116732.1
fruit fly (Drosophila melanogaster)	Insecta	CG10231³ Pde11¹	cGMP-specific phosphodiesterase³ Phosphodiesterase 11¹	48(a) (best of 2)³ 53.26(n)¹ 49.52(a)¹		35107¹ NM_136041.2¹ NP_609885.2¹

ENSEMBL Gene Tree for PDE5A (if available)
TreeFam Gene Tree for PDE5A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PDE5A gene

PDE6A² PDE11A² PDE2A² PDE6B² PDE10A² PDE6C²

9 SIMAP similar genes for PDE5A using alignment to 9 protein entries: PDE5A_HUMAN (see all proteins):

PDE11A PDE6B PDE6A PDE2A PDE4 PDE10A

PDE6C PDE7B variant protein PDE9A

PDE5A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185213099^1,2		--	120415154(+)	`AAAGAA/GAACTA`	4	--	ds500¹ int¹		0	--	--	--	--
rs190487471^1,2		--	120415159(+)	`GAACTA/CAGGAA`	4	--	int¹ ds500¹		0	--	--	--	--
rs115180155^1,2	C,F	--	120415175(+)	`CCCTTG/ACTTTG`	4	--	int¹ ds500¹		1		WA	118
rs13116789^1,2	C,F,H	--	120415212(+)	`CAGCTC/TATGCC`	4	--	ds500¹ int¹		10		NS EA NA	660
rs181911545^1,2		--	120415394(+)	`CTAGGC/TTAAGG`	4	--	int¹ ds500¹		0	--	--	--	--
rs80154562^1,2	C,F	--	120415526(+)	`ATTCAG/TAGTCC`	4	--	ds500¹ int¹		1		EA	120
rs1045177^1,2	C,F,H	--	120415676(-)	`TACCTC/TCGATT`	4	--	nc-transcript-variantut3¹ ese³		10		MN NS EA NA	1572
rs147992500^1,2	C	--	120415681(+)	`GAGGTA/GAGTGT`	4	--	int¹ ut3¹		0	--	--	--	--
rs78173532^1,2	C,F	--	120415713(+)	`TGAAAG/AAGTCA`	4	--	ut3¹ int¹		1		WA	118
rs183933035^1,2		--	120415829(+)	`TCCTAA/GTATAA`	4	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PDE5A (120415550 - 120550146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDE5A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PDE5A for disorders           About GeneDecksing

OMIM gene information: 603310    OMIM disorders: --

20/61 diseases for PDE5A (see all 61):    About MalaCards

transient global amnesia ischemic optic neuropathy premature ejaculation pre-eclampsia

sensorineural hearing loss primary pulmonary hypertension type 2 diabetes mellitus peyronie's disease

peyronies disease priapism pulmonary hypertension impotence

congestive heart failure hearing loss diabetes mellitus myocardial infarction

ischemic heart disease muscle hypertrophy pulmonary embolism optic atrophy

10 diseases from the University of Copenhagen DISEASES database for PDE5A:

Premature ejaculation Sexual dysfunction Hypertension Priapism

Ischemic optic neuropathy Hypogonadism Dyspepsia Peyronie's disease

Diabetes mellitus Heart disease

10/50 Novoseek disease relationships for PDE5A gene (see all 50) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
erectile dysfunction	95.8	275	17253475 (5), 17948826 (3), 17076943 (3), 18674473 (3) (see all 99)
hypertension pulmonary	71.8	42	17305584 (2), 19416631 (2), 15907910 (2), 15817798 (2) (see all 33)
benign prostatic hyperplasia	66.3	14	16387566 (1), 16956354 (1), 19796053 (1), 17329019 (1) (see all 11)
naion	64.7	32	17076943 (4), 18528398 (4), 17947271 (3), 17969789 (1) (see all 9)
hypertension arterial	63.6	29	17606845 (2), 15907910 (2), 18689467 (2), 15466636 (1) (see all 23)
priapism	63.5	25	17100941 (5), 12853767 (3), 16698365 (3), 19267844 (2) (see all 8)
hypogonadism	62.7	8	16939550 (2), 17309554 (2), 16422803 (1), 18641415 (1)
congestion	50.4	5	12161769 (1), 15224134 (1), 15115191 (1), 11249556 (1) (see all 5)
peyronie disease	50	2	17942972 (1), 16885993 (1)
impotence	49.6	4	10541153 (1), 18778098 (1), 12789393 (1), 17017938 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: PDE5A (6 documents)

Export disorders for PDE5A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PDE5A gene, integrated from 9 sources (see all 609):
(articles sorted by number of sources associating them with PDE5A)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (PubMed id 9714779)^{1, 2, 3, 9} Loughney K.... Ferguson K. (1998)
Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (PubMed id 12955149)^{1, 2, 7} Sung B.-J.... Cho J.M. (2003)
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase. (PubMed id 9642111)^{1, 2, 3} Stacey P.... Phillips S.C. (1998)
PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. (PubMed id 12554648)^{1, 7, 9} Rybalkin S.D....Beavo J.A. (2003)
Expression, structure and chromosomal localization of the human cGMP- binding cGMP-specific phosphodiesterase PDE5A gene. (PubMed id 9716380)^{1, 2, 9} Yanaka N.... Omori K. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells. (PubMed id 10393044)^{1, 2} Zhou L.... Potter D.E. (1999)
Oxidative stress regulates left ventricular PDE5 expression in the failing heart. (PubMed id 20308615)^{1, 9} Lu Z....Chen Y. (2010)
Expression and role of phosphodiesterase 5 in human m alignant melanoma cell line. (PubMed id 20332439)^{1, 9} Murata T....Tagawa T. (2010)
Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases. (PubMed id 10411650)^{1, 9} Kotera J....Omori K. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8654	HGNC: 8784	AceView: PDE5A	Ensembl:ENSG00000138735	euGenes: HUgn8654
ECgene: PDE5A	Kegg: 8654	H-InvDB: PDE5A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PDE5A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PDE5A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PDE5A gene:
Search GeneIP for patents involving PDE5A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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phosphodiesterase 5A, cGMP-specific

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